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About
What is Reactome ?
News
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Statistics
Our Logo
License Agreement
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Table of Contents
DOIs
Data Schema
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ADP [cytosol]
Stable Identifier
R-ALL-29370
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
Adenosine 5'-diphosphate, ADP(3-)
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Mycobacterium tuberculosis
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Autophagy (Bos taurus)
Macroautophagy (Bos taurus)
AMPK (complex) phosphorylates ULK1 (complex) (Bos taurus)
ADP [cytosol]
Active mTORC1 phosphorylates ULK1 (Bos taurus)
ADP [cytosol]
Beclin-1 complex phosphorylates PtdIns (Bos taurus)
ADP [cytosol]
Selective autophagy (Bos taurus)
Mitophagy (Bos taurus)
Receptor Mediated Mitophagy (Bos taurus)
FUNDC1 is phosphorylated by CK2 (Bos taurus)
ADP [cytosol]
FUNDC1 is phosphorylated by ULK1 at Ser17 (Bos taurus)
ADP [cytosol]
p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Bos taurus)
ADP [cytosol]
Thr-180 of ULK1 is phosphorylated (Bos taurus)
ADP [cytosol]
ULK1 phosphorylates AMBRA1:Beclin-1 complex (Bos taurus)
ADP [cytosol]
ULK1 phosphorylates ATG13 and RB1CC1 (Bos taurus)
ADP [cytosol]
ULK1 phosphorylates Beclin-1 (Bos taurus)
ADP [cytosol]
p-AMPK:AMP phosphorylates Raptor in the mTORC1 complex (Bos taurus)
ADP [cytosol]
Cell Cycle (Bos taurus)
Cell Cycle Checkpoints (Bos taurus)
G2/M Checkpoints (Bos taurus)
G2/M DNA replication checkpoint (Bos taurus)
Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Bos taurus)
ADP [cytosol]
Cell Cycle, Mitotic (Bos taurus)
M Phase (Bos taurus)
Mitotic Prometaphase (Bos taurus)
Condensation of Prometaphase Chromosomes (Bos taurus)
CK2 phosphorylates condensin I subunits (Bos taurus)
ADP [cytosol]
EML4 and NUDC in mitotic spindle formation (Bos taurus)
NEK6 and NEK7 phosphorylate EML4 (Bos taurus)
ADP [cytosol]
PLK1 phosphorylates NUDC (Bos taurus)
ADP [cytosol]
Resolution of Sister Chromatid Cohesion (Bos taurus)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Bos taurus)
ADP [cytosol]
CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Bos taurus)
ADP [cytosol]
Phosphorylation of cohesin by PLK1 at centromeres (Bos taurus)
ADP [cytosol]
Phosphorylation of cohesin by PLK1 at chromosomal arms (Bos taurus)
ADP [cytosol]
Mitotic Prophase (Bos taurus)
Golgi Cisternae Pericentriolar Stack Reorganization (Bos taurus)
MAPK3-3 or MAPK1 phosphorylate GORASP2 (Bos taurus)
ADP [cytosol]
PLK1 phosphorylates GORASP1 (Bos taurus)
ADP [cytosol]
Nuclear Envelope Breakdown (Bos taurus)
Activation of NIMA Kinases NEK9, NEK6, NEK7 (Bos taurus)
CDK1:CCNB phosphorylates NEK9 (Bos taurus)
ADP [cytosol]
NEK9 phosphorylates NEK6/NEK7 (Bos taurus)
ADP [cytosol]
PLK1 phosphorylates NEK9 (Bos taurus)
ADP [cytosol]
Nuclear Pore Complex (NPC) Disassembly (Bos taurus)
CDK1 phosphorylates NUP98 (Bos taurus)
ADP [cytosol]
NEK6/NEK7 phosphorylates NUP98 (Bos taurus)
ADP [cytosol]
Mitotic G1 phase and G1/S transition (Bos taurus)
G1 Phase (Bos taurus)
Cyclin D associated events in G1 (Bos taurus)
Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Bos taurus)
ADP [cytosol]
G1/S Transition (Bos taurus)
Cyclin E associated events during G1/S transition (Bos taurus)
SCF(Skp2)-mediated degradation of p27/p21 (Bos taurus)
PTK6 phosphorylates CDKN1B (Bos taurus)
ADP [cytosol]
Mitotic G2-G2/M phases (Bos taurus)
G2/M Transition (Bos taurus)
AURKA Activation by TPX2 (Bos taurus)
TPX2 promotes AURKA autophosphorylation (Bos taurus)
ADP [cytosol]
Centrosome maturation (Bos taurus)
Loss of proteins required for interphase microtubule organization from the centrosome (Bos taurus)
Loss of Nlp from mitotic centrosomes (Bos taurus)
Plk1-mediated phosphorylation of Nlp (Bos taurus)
ADP [cytosol]
Cyclin A/B1/B2 associated events during G2/M transition (Bos taurus)
Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Bos taurus)
ADP [cytosol]
Phosphorylation of Cyclin B1 in the CRS domain (Bos taurus)
ADP [cytosol]
Interaction between PHLDA1 and AURKA (Bos taurus)
AURKA phosphorylates PHLDA1 (Bos taurus)
ADP [cytosol]
Polo-like kinase mediated events (Bos taurus)
Activation of Cdc25C (Bos taurus)
ADP [cytosol]
Regulation of PLK1 Activity at G2/M Transition (Bos taurus)
AJUBA facilitates AURKA autophosphorylation (Bos taurus)
ADP [cytosol]
AURKA phosphorylates PLK1 (Bos taurus)
ADP [cytosol]
CDK1 phosphorylates BORA (Bos taurus)
ADP [cytosol]
PLK1 phosphorylates BORA (Bos taurus)
ADP [cytosol]
PLK1 phosphorylates OPTN (Bos taurus)
ADP [cytosol]
The role of GTSE1 in G2/M progression after G2 checkpoint (Bos taurus)
PLK1 phosphorylates GTSE1 (Bos taurus)
ADP [cytosol]
S Phase (Bos taurus)
Cyclin A:Cdk2-associated events at S phase entry (Bos taurus)
SCF(Skp2)-mediated degradation of p27/p21 (Bos taurus)
PTK6 phosphorylates CDKN1B (Bos taurus)
ADP [cytosol]
Cell-Cell communication (Bos taurus)
Nephrin family interactions (Bos taurus)
Phosphorylation of nephrin by FYN (Bos taurus)
ADP [cytosol]
Cellular responses to external stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular Senescence (Bos taurus)
Oxidative Stress Induced Senescence (Bos taurus)
MAP3K5 phosphorylates MKK3 and MKK6 (Bos taurus)
ADP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ADP [cytosol]
Cellular response to heat stress (Bos taurus)
Regulation of HSF1-mediated heat shock response (Bos taurus)
Constitutive phosphorylation by pERK1/2 (Bos taurus)
ADP [cytosol]
Constitutive phosphorylation by GSK3 (Bos taurus)
ADP [cytosol]
HSP110s exchange ATP for ADP on HSP70s:ADP (Bos taurus)
ADP [cytosol]
HSP70s:ADP [cytosol] (Bos taurus)
HSP13:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSP14:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA12A:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA12B:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA1A:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA1L:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA4:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA4L:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA5:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA6:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA7:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA8:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA9:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Bos taurus)
HSP70s:ADP [cytosol] (Bos taurus)
HSP13:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSP14:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA12A:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA12B:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA1A:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA1L:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA4:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA4L:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA5:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA6:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA7:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA8:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA9:ADP [cytosol] (Bos taurus)
ADP [cytosol]
MAPKAPK2 phosphorylates HSF1 (Bos taurus)
ADP [cytosol]
HSP90 chaperone cycle for steroid hormone receptors (SHR) (Bos taurus)
ATP binding to HSP90 triggers conformation change (Bos taurus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Bos taurus)
HSP70:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSP90:STIP1:HSP70:nascent protein [cytosol] (Bos taurus)
HSP70:ADP:nascent protein [cytosol] (Bos taurus)
HSP70:ADP [cytosol] (Bos taurus)
ADP [cytosol]
ATP hydrolysis by HSP70 (Bos taurus)
HSP40:HSP70:ADP:nascent protein [cytosol] (Bos taurus)
ADP [cytosol]
FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Bos taurus)
HSP90:ATP:FKBP5:STIP1:HSP70:nascent protein [cytosol] (Bos taurus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Bos taurus)
HSP70:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Bos taurus)
HSP70:ADP [cytosol] (Bos taurus)
ADP [cytosol]
STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Bos taurus)
HSP40:HSP70:ADP:nascent protein [cytosol] (Bos taurus)
ADP [cytosol]
HSP90:STIP1:HSP70:nascent protein [cytosol] (Bos taurus)
HSP70:ADP:nascent protein [cytosol] (Bos taurus)
HSP70:ADP [cytosol] (Bos taurus)
ADP [cytosol]
p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Bos taurus)
HSP90:ATP:FKBP5:STIP1:HSP70:nascent protein [cytosol] (Bos taurus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Bos taurus)
HSP70:ADP [cytosol] (Bos taurus)
ADP [cytosol]
Developmental Biology (Bos taurus)
Axon guidance (Bos taurus)
EPH-Ephrin signaling (Bos taurus)
EPH receptors autophosphorylate (Bos taurus)
ADP [cytosol]
EPH-ephrin mediated repulsion of cells (Bos taurus)
SFKs phosphorylate VAV2,3 (Bos taurus)
ADP [cytosol]
EPHB-mediated forward signaling (Bos taurus)
EPHB phosphorylates TIAM1 (Bos taurus)
ADP [cytosol]
PAK1 autophosphorylates (Bos taurus)
ADP [cytosol]
p-EPHB phosphorylates SDC2 (Bos taurus)
ADP [cytosol]
Ephrin signaling (Bos taurus)
PAKs autophosphorylate (Bos taurus)
ADP [cytosol]
PAKs phosphorylate MLC (Bos taurus)
ADP [cytosol]
L1CAM interactions (Bos taurus)
Signal transduction by L1 (Bos taurus)
Interaction of PAK1 with Rac1-GTP (Bos taurus)
ADP [cytosol]
MAP2K1 phosphorylates MAPK3 (Bos taurus)
ADP [cytosol]
MAP2K2 phosphorylates MAPK1 (Bos taurus)
ADP [cytosol]
Netrin-1 signaling (Bos taurus)
DCC mediated attractive signaling (Bos taurus)
Phosphorylation of DCC by Fyn (Bos taurus)
ADP [cytosol]
DSCAM interactions (Bos taurus)
Activation of JNK by DSCAM (Bos taurus)
ADP [cytosol]
Activation of p38MAPK by DSCAM (Bos taurus)
ADP [cytosol]
Phosphorylation and activation of Ezrin (Bos taurus)
ADP [cytosol]
RET signaling (Bos taurus)
GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Bos taurus)
ADP [cytosol]
PKA phosphorylates RET:GDNF:GFRA dimer (Bos taurus)
ADP [cytosol]
RET tyrosine phosphorylation (Bos taurus)
ADP [cytosol]
Reelin signalling pathway (Bos taurus)
FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Bos taurus)
ADP [cytosol]
Semaphorin interactions (Bos taurus)
CRMPs in Sema3A signaling (Bos taurus)
Phosphorylation of CRMPs by Cdk5 (Bos taurus)
ADP [cytosol]
Phosphorylation of CRMPs by GSK3beta (Bos taurus)
ADP [cytosol]
Tyrosine phosphorylation of CRMPs by Fes (Bos taurus)
ADP [cytosol]
Sema3A PAK dependent Axon repulsion (Bos taurus)
Autophosphorylation of PAK (Bos taurus)
ADP [cytosol]
Phosphorylation of LIMK-1 by PAK (Bos taurus)
ADP [cytosol]
Transphosphorylation of pLIMK1 (Bos taurus)
ADP [cytosol]
Sema4D in semaphorin signaling (Bos taurus)
Sema4D induced cell migration and growth-cone collapse (Bos taurus)
SEMA4D interacts with Plexin-B1:ErbB2 (Bos taurus)
ADP [cytosol]
Signaling by ROBO receptors (Bos taurus)
Role of ABL in ROBO-SLIT signaling (Bos taurus)
Phosphorylation of ROBO1 by ABL kinase (Bos taurus)
ADP [cytosol]
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional Regulation by TP53 (Bos taurus)
Regulation of TP53 Activity (Bos taurus)
Regulation of TP53 Expression and Degradation (Bos taurus)
Regulation of TP53 Degradation (Bos taurus)
PDPK1 phosphorylates SGK1 (Bos taurus)
ADP [cytosol]
SGK1 phosphorylates MDM2 (Bos taurus)
ADP [cytosol]
TORC2 complex phosphorylates SGK1 (Bos taurus)
ADP [cytosol]
TP53 Regulates Metabolic Genes (Bos taurus)
p-AMPK phosphorylates TSC1:TSC2 (Bos taurus)
ADP [cytosol]
TP53 Regulates Transcription of Cell Cycle Genes (Bos taurus)
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Bos taurus)
PLK2 phosphorylates CENPJ (Bos taurus)
ADP [cytosol]
PLK2 phosphorylates NPM1 (Bos taurus)
ADP [cytosol]
Transcriptional regulation by RUNX3 (Bos taurus)
Regulation of RUNX3 expression and activity (Bos taurus)
SRC phosphorylates RUNX3 (Bos taurus)
ADP [cytosol]
Hemostasis (Bos taurus)
Cell surface interactions at the vascular wall (Bos taurus)
PECAM1 interactions (Bos taurus)
Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Bos taurus)
ADP [cytosol]
Factors involved in megakaryocyte development and platelet production (Bos taurus)
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Bos taurus)
ADP [cytosol]
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Bos taurus)
ADP [cytosol]
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Bos taurus)
ADP [cytosol]
Kinesins (Bos taurus)
Kinesins move along microtubules consuming ATP (Bos taurus)
ADP [cytosol]
Platelet activation, signaling and aggregation (Bos taurus)
Effects of PIP2 hydrolysis (Bos taurus)
DAG kinase produces phosphatidic acid from DAG (Bos taurus)
ADP [cytosol]
GPVI-mediated activation cascade (Bos taurus)
Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Bos taurus)
ADP [cytosol]
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
SYK autophosphorylates (Bos taurus)
ADP [cytosol]
Syk activation leads to SLP-76 activation (Bos taurus)
ADP [cytosol]
Syk/Lck phosphorylate LAT (Bos taurus)
ADP [cytosol]
Unknown kinase phosphorylates CLEC1B dimer:PDPN (Bos taurus)
ADP [cytosol]
Response to elevated platelet cytosolic Ca2+ (Bos taurus)
Disinhibition of SNARE formation (Bos taurus)
Phosphorylation of Platelet Sec-1 (Bos taurus)
ADP [cytosol]
Phosphorylation of Syntaxin-4 (Bos taurus)
ADP [cytosol]
Platelet degranulation (Bos taurus)
ABCC4 accumulation of dense granule contents (Bos taurus)
ADP [cytosol]
Signal amplification (Bos taurus)
ADP signalling through P2Y purinoceptor 1 (Bos taurus)
P2Y purinoceptor 1 activates MAP kinase p38 alpha (Bos taurus)
ADP [cytosol]
Phosphorylation of cPLA2 by MAPK p38 alpha (Bos taurus)
ADP [cytosol]
Platelet homeostasis (Bos taurus)
Platelet sensitization by LDL (Bos taurus)
FGR binds and phosphorylates LRP8 (Bos taurus)
ADP [cytosol]
Fgr may phosphorylate p38 MAPK (Bos taurus)
ADP [cytosol]
PECAM1 is phosphorylated (Bos taurus)
ADP [cytosol]
Phosphorylation of cPLA2 by MAPK p38 alpha (Bos taurus)
ADP [cytosol]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Bos taurus)
Transport of Antigen peptide in to ER (Bos taurus)
ADP [cytosol]
Costimulation by the CD28 family (Bos taurus)
CD28 co-stimulation (Bos taurus)
CD28 dependent PI3K/Akt signaling (Bos taurus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
p-S400-Cot phosphorylates NIK (Bos taurus)
ADP [cytosol]
PD-1 signaling (Bos taurus)
Phosphorylation of PD-1 (Bos taurus)
ADP [cytosol]
Rap1 signalling (Bos taurus)
PKA/PKG phosphorylate Rap1GAP2 (Bos taurus)
ADP [cytosol]
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)
PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Bos taurus)
ADP [cytosol]
Downstream signaling events of B Cell Receptor (BCR) (Bos taurus)
Activation of NF-kappaB in B cells (Bos taurus)
Activated IKK phosphorylates I-kappaB (Bos taurus)
ADP [cytosol]
PRKCB (PKC-beta) phosphorylates CARMA1 (Bos taurus)
ADP [cytosol]
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
Activation of IKK complex (Bos taurus)
ADP [cytosol]
Activation of TAK1-TAB2 complex (Bos taurus)
ADP [cytosol]
Change of PKC theta conformation (Bos taurus)
ADP [cytosol]
Phosphorylation of Bcl10 (Bos taurus)
ADP [cytosol]
Phosphorylation of CARMA1 (Bos taurus)
ADP [cytosol]
Phosphorylation of PKC theta (Bos taurus)
ADP [cytosol]
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Bos taurus)
ADP [cytosol]
Generation of second messenger molecules (Bos taurus)
Phosphorylation of PLC-gamma1 (Bos taurus)
ADP [cytosol]
Phosphorylation of SLP-76 (Bos taurus)
ADP [cytosol]
Phosphorylation of TBSMs in LAT (Bos taurus)
ADP [cytosol]
Phosphorylation of CD3 and TCR zeta chains (Bos taurus)
Activation of Lck (Bos taurus)
ADP [cytosol]
Inactivation of Lck by Csk (Bos taurus)
ADP [cytosol]
Phosphorylation of ITAM motifs in CD3 complexes (Bos taurus)
ADP [cytosol]
Translocation of ZAP-70 to Immunological synapse (Bos taurus)
Activation of ZAP-70 (Bos taurus)
ADP [cytosol]
Phosphorylation of ZAP-70 by Lck (Bos taurus)
ADP [cytosol]
Cytokine Signaling in Immune system (Bos taurus)
FLT3 Signaling (Bos taurus)
PI3K Cascade (Bos taurus)
Activation of AKT2 (Bos taurus)
PDPK1 phosphorylates AKT2 (Bos taurus)
ADP [cytosol]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
RAF/MAP kinase cascade (Bos taurus)
MAP2K and MAPK activation (Bos taurus)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Bos taurus)
ADP [cytosol]
MAP2Ks phosphorylate MAPK at the Golgi membrane (Bos taurus)
ADP [cytosol]
MAP2Ks phosphorylate MAPKs (Bos taurus)
ADP [cytosol]
RAF phosphorylates MAP2K dimer (Bos taurus)
ADP [cytosol]
Negative regulation of MAPK pathway (Bos taurus)
Negative feedback regulation of MAPK pathway (Bos taurus)
Activated MAPK phosphorylates RAF1 (Bos taurus)
ADP [cytosol]
Activated MAPKs phosphorylate BRAF (Bos taurus)
ADP [cytosol]
Activated MAPKs phosphorylate MAP2K1 (Bos taurus)
ADP [cytosol]
RAF activation (Bos taurus)
MARK3 phosphorylates KSR1 (Bos taurus)
ADP [cytosol]
Phosphorylation of RAF (Bos taurus)
ADP [cytosol]
Growth hormone receptor signaling (Bos taurus)
JAK2 phosphorylation (Bos taurus)
ADP [cytosol]
Lyn activates ERK (Bos taurus)
ADP [cytosol]
Interferon Signaling (Bos taurus)
Interferon alpha/beta signaling (Bos taurus)
Activation of JAK kinases (Bos taurus)
ADP [cytosol]
Formation of p-STAT1 homodimer (Bos taurus)
ADP [cytosol]
Phosphorylation of INFAR1 by TYK2 (Bos taurus)
ADP [cytosol]
Phosphorylation of STAT1 (Bos taurus)
ADP [cytosol]
Phosphorylation of STAT2 (Bos taurus)
ADP [cytosol]
Interferon gamma signaling (Bos taurus)
Phosphorylation of IFNGR1 by JAK kinases (Bos taurus)
ADP [cytosol]
Phosphorylation of JAK2 (Bos taurus)
ADP [cytosol]
Phosphorylation of STAT1 at Ser727 (Bos taurus)
ADP [cytosol]
Phosphorylation of STAT1 by JAK kinases (Bos taurus)
ADP [cytosol]
Transphosphorylation of JAK1 (Bos taurus)
ADP [cytosol]
Prolactin receptor signaling (Bos taurus)
JAK2 phosphorylation (Bos taurus)
ADP [cytosol]
PRLR is phosphorylated at Ser-349 (Bos taurus)
ADP [cytosol]
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 signaling (Bos taurus)
Activated TAK1 mediates phosphorylation of the IKK Complex (Bos taurus)
ADP [cytosol]
IKBA is phosphorylated by Phospho IKKB kinase (Bos taurus)
ADP [cytosol]
IRAK4 is activated by autophosphorylation (Bos taurus)
ADP [cytosol]
IRAK4 phosphorylates IRAK1 (Bos taurus)
ADP [cytosol]
IRAK4-activated IRAK1 autophosphorylates (Bos taurus)
ADP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
ADP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
ADP [cytosol]
MAP3K8 is phosphorylated (Bos taurus)
ADP [cytosol]
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Bos taurus)
Activated TAK1 mediates phosphorylation of the IKK Complex (Bos taurus)
ADP [cytosol]
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Bos taurus)
ADP [cytosol]
TAK1 phosphorylates MKK6 (Bos taurus)
ADP [cytosol]
hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Bos taurus)
ADP [cytosol]
Interleukin-37 signaling (Bos taurus)
TBK1 phosphorylation (Bos taurus)
ADP [cytosol]
Interleukin-38 signaling (Bos taurus)
MAPK8 phosphorylation (Bos taurus)
ADP [cytosol]
Interleukin-10 signaling (Bos taurus)
JAK1,TYK2 phosphorylate JAK1,TYK2 (Bos taurus)
ADP [cytosol]
p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Bos taurus)
ADP [cytosol]
Interleukin-12 family signaling (Bos taurus)
Interleukin-23 signaling (Bos taurus)
STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Bos taurus)
ADP [cytosol]
Interleukin-27 signaling (Bos taurus)
IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Bos taurus)
ADP [cytosol]
JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Bos taurus)
ADP [cytosol]
STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Bos taurus)
ADP [cytosol]
Interleukin-35 Signalling (Bos taurus)
JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Bos taurus)
ADP [cytosol]
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Bos taurus)
ADP [cytosol]
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Bos taurus)
ADP [cytosol]
Interleukin-17 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
ADP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ADP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
ADP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
ADP [cytosol]
MAP3K8 is phosphorylated (Bos taurus)
ADP [cytosol]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ADP [cytosol]
Interleukin-2 family signaling (Bos taurus)
Interleukin receptor SHC signaling (Bos taurus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Bos taurus)
ADP [cytosol]
Interleukin-15 signaling (Bos taurus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Bos taurus)
ADP [cytosol]
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Bos taurus)
ADP [cytosol]
Interleukin-2 signaling (Bos taurus)
JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Bos taurus)
ADP [cytosol]
SHC1 bound to IL2 receptor is phosphorylated (Bos taurus)
ADP [cytosol]
SYK is a substrate for JAK1 (Bos taurus)
ADP [cytosol]
Within the IL-2R complex JAK3 phosphorylates JAK1 (Bos taurus)
ADP [cytosol]
Interleukin-21 signaling (Bos taurus)
IL21 receptor JAK phosphorylation (Bos taurus)
ADP [cytosol]
IL21 receptor STAT phosphorylation (Bos taurus)
ADP [cytosol]
Interleukin-9 signaling (Bos taurus)
IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Bos taurus)
ADP [cytosol]
IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Bos taurus)
ADP [cytosol]
IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Bos taurus)
ADP [cytosol]
Interleukin-20 family signaling (Bos taurus)
IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Bos taurus)
ADP [cytosol]
IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Bos taurus)
ADP [cytosol]
IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Bos taurus)
ADP [cytosol]
IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Bos taurus)
ADP [cytosol]
IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Bos taurus)
ADP [cytosol]
IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Bos taurus)
ADP [cytosol]
IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Bos taurus)
ADP [cytosol]
IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Bos taurus)
ADP [cytosol]
IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Bos taurus)
ADP [cytosol]
IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 (Bos taurus)
ADP [cytosol]
IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Bos taurus)
ADP [cytosol]
JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Bos taurus)
ADP [cytosol]
Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
Activation of STAT5a/b by JAK2 (Bos taurus)
ADP [cytosol]
Interleukin receptor SHC signaling (Bos taurus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Bos taurus)
ADP [cytosol]
JAK2 is phosphorylated, activated (Bos taurus)
ADP [cytosol]
Tyrosine kinases phosphorylate the receptor (Bos taurus)
ADP [cytosol]
Interleukin-4 and Interleukin-13 signaling (Bos taurus)
IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Bos taurus)
ADP [cytosol]
IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Bos taurus)
ADP [cytosol]
JAK1 phosphorylates STAT3,STAT6 (Bos taurus)
ADP [cytosol]
STAT1,STAT3,STAT6 phosphorylation (Bos taurus)
ADP [cytosol]
Interleukin-6 family signaling (Bos taurus)
Interleukin-6 signaling (Bos taurus)
IL6ST is tyrosine phosphorylated (Bos taurus)
ADP [cytosol]
JAK activation (Bos taurus)
ADP [cytosol]
PTPN11 is phosphorylated (Bos taurus)
ADP [cytosol]
Serine phosphorylation of STATs (Bos taurus)
ADP [cytosol]
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Bos taurus)
ADP [cytosol]
Interleukin-7 signaling (Bos taurus)
JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Bos taurus)
ADP [cytosol]
TNFR2 non-canonical NF-kB pathway (Bos taurus)
NIK-->noncanonical NF-kB signaling (Bos taurus)
Active NIK phosphorylates IKKA dimer (Bos taurus)
ADP [cytosol]
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Bos taurus)
ADP [cytosol]
NIK autophosphorylates on T559 (Bos taurus)
ADP [cytosol]
Innate Immune System (Bos taurus)
Alpha-protein kinase 1 signaling pathway (Bos taurus)
ALPK1 phosphorylates TIFA (Bos taurus)
ADP [cytosol]
Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Bos taurus)
ADP [cytosol]
Antimicrobial peptides (Bos taurus)
Ion influx/efflux at host-pathogen interface (Bos taurus)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Bos taurus)
ADP [cytosol]
C-type lectin receptors (CLRs) (Bos taurus)
CD209 (DC-SIGN) signaling (Bos taurus)
PAK phosphorylates p21 RAF1 on S338 (Bos taurus)
ADP [cytosol]
SFKs phosphorylates RAF1 on Y340,Y341 (Bos taurus)
ADP [cytosol]
CLEC7A (Dectin-1) signaling (Bos taurus)
Dectin-1 mediated noncanonical NF-kB signaling (Bos taurus)
Active NIK phosphorylates IKKA dimer (Bos taurus)
ADP [cytosol]
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Bos taurus)
ADP [cytosol]
K63polyUb-TAK1 autophosphorylates (Bos taurus)
ADP [cytosol]
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Bos taurus)
ADP [cytosol]
PKC-delta phosphorylates CARD9 (Bos taurus)
ADP [cytosol]
SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Bos taurus)
ADP [cytosol]
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Bos taurus)
ADP [cytosol]
Dectin-2 family (Bos taurus)
LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Bos taurus)
ADP [cytosol]
SYK autophosphorylates (Bos taurus)
ADP [cytosol]
SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Bos taurus)
ADP [cytosol]
Cytosolic sensors of pathogen-associated DNA (Bos taurus)
STING mediated induction of host immune responses (Bos taurus)
IRF3-mediated induction of type I IFN (Bos taurus)
IRF3 is phosphorylated by TBK1 (Bos taurus)
ADP [cytosol]
TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Bos taurus)
ADP [cytosol]
STAT6-mediated induction of chemokines (Bos taurus)
TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Bos taurus)
ADP [cytosol]
TBK1 phosphorylates STAT6 at Ser407 (Bos taurus)
ADP [cytosol]
p-S407-STAT6 is phosphorylated at Tyr641 (Bos taurus)
ADP [cytosol]
ZBP1(DAI) mediated induction of type I IFNs (Bos taurus)
RIP-mediated NFkB activation via ZBP1 (Bos taurus)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Bos taurus)
ADP [cytosol]
DAP12 interactions (Bos taurus)
DAP12 signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
Phosphorylation and activation of VAV2/VAV3 by SYK (Bos taurus)
ADP [cytosol]
Phosphorylation of BTK by p-SYK (Bos taurus)
ADP [cytosol]
Phosphorylation of LAT by p-SYK (Bos taurus)
ADP [cytosol]
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Bos taurus)
ADP [cytosol]
Phosphorylation of SLP-76 by p-SYK (Bos taurus)
ADP [cytosol]
Phosphorylation of SYK (Bos taurus)
ADP [cytosol]
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Bos taurus)
TRAF6 mediated NF-kB activation (Bos taurus)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Bos taurus)
ADP [cytosol]
Fc epsilon receptor (FCERI) signaling (Bos taurus)
Autophosphorylation of LYN kinase (Bos taurus)
ADP [cytosol]
FCERI mediated Ca+2 mobilization (Bos taurus)
Autophosphorylation of BTK/ITK (Bos taurus)
ADP [cytosol]
FCERI mediated MAPK activation (Bos taurus)
Autophosphorylation of PAK (Bos taurus)
ADP [cytosol]
Phosphorylation and activation of VAV (Bos taurus)
ADP [cytosol]
Phosphorylation of MEK4 by MEKK1 (Bos taurus)
ADP [cytosol]
Phosphorylation of MEK7 by MEKK1 (Bos taurus)
ADP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ADP [cytosol]
FCERI mediated NF-kB activation (Bos taurus)
Activation of TAK1 complex bound to pUb-TRAF6 (Bos taurus)
ADP [cytosol]
Autophosphorylation of PKC-theta (Bos taurus)
ADP [cytosol]
Phosphorylation of CARMA1 by PKC-theta (Bos taurus)
ADP [cytosol]
Phosphorylation of IKK-beta by TAK1 (Bos taurus)
ADP [cytosol]
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Bos taurus)
ADP [cytosol]
Role of LAT2/NTAL/LAB on calcium mobilization (Bos taurus)
Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)
ADP [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
ABL phosphorylates WAVEs (Bos taurus)
ADP [cytosol]
Autophosphorylation of PAK1 (Bos taurus)
ADP [cytosol]
Branching and elongation of mother and daughter filaments (Bos taurus)
Mother filament:ARP2/3:actin:ADP [cytosol] (Bos taurus)
Actin:ADP [cytosol] (Bos taurus)
ADP [cytosol]
Detachment of WASP/WAVE (Bos taurus)
Mother filament:ARP2/3:actin:ADP [cytosol] (Bos taurus)
Actin:ADP [cytosol] (Bos taurus)
ADP [cytosol]
PAK1 phosphorylates LIMK1 (Bos taurus)
ADP [cytosol]
Phosphorylation of VAV (Bos taurus)
ADP [cytosol]
Src family kinases (SFKs) phosphorylate WASP/N-WASP (Bos taurus)
ADP [cytosol]
Transphosphorylation of pLIMK1 (Bos taurus)
ADP [cytosol]
p-ERK phosphorylates WAVEs and ABI (Bos taurus)
ADP [cytosol]
Role of phospholipids in phagocytosis (Bos taurus)
DAG stimulates protein kinase C-delta (Bos taurus)
ADP [cytosol]
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
Phosphorylation and activation of PLCG (Bos taurus)
ADP [cytosol]
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Bos taurus)
NOD1/2 Signaling Pathway (Bos taurus)
Activated TAK1 mediates phosphorylation of the IKK Complex (Bos taurus)
ADP [cytosol]
Activation of p38 MAPK (Bos taurus)
ADP [cytosol]
TAK1 phosphorylates MKK6 (Bos taurus)
ADP [cytosol]
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
IRAK1 phosphorylates Pellino (Bos taurus)
ADP [cytosol]
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Bos taurus)
ADP [cytosol]
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
ADP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ADP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
ADP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
ADP [cytosol]
MAP3K8 is phosphorylated (Bos taurus)
ADP [cytosol]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ADP [cytosol]
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Bos taurus)
Activated TAK1 mediates phosphorylation of the IKK Complex (Bos taurus)
ADP [cytosol]
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Bos taurus)
ADP [cytosol]
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
IRAK1 phosphorylates Pellino (Bos taurus)
ADP [cytosol]
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Bos taurus)
ADP [cytosol]
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
ADP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ADP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
ADP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
ADP [cytosol]
MAP3K8 is phosphorylated (Bos taurus)
ADP [cytosol]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ADP [cytosol]
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Bos taurus)
Activated TAK1 mediates phosphorylation of the IKK Complex (Bos taurus)
ADP [cytosol]
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Bos taurus)
ADP [cytosol]
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
IRAK1 phosphorylates Pellino (Bos taurus)
ADP [cytosol]
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Bos taurus)
ADP [cytosol]
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
ADP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ADP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
ADP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
ADP [cytosol]
MAP3K8 is phosphorylated (Bos taurus)
ADP [cytosol]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ADP [cytosol]
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Bos taurus)
Activated TAK1 mediates phosphorylation of the IKK Complex (Bos taurus)
ADP [cytosol]
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Bos taurus)
ADP [cytosol]
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
ADP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ADP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
ADP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
ADP [cytosol]
MAP3K8 is phosphorylated (Bos taurus)
ADP [cytosol]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ADP [cytosol]
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Bos taurus)
Activated TAK1 mediates phosphorylation of the IKK Complex (Bos taurus)
ADP [cytosol]
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Bos taurus)
ADP [cytosol]
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF(TICAM1)-mediated TLR4 signaling (Bos taurus)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (Bos taurus)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Bos taurus)
ADP [cytosol]
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
ADP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ADP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
ADP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
ADP [cytosol]
MAP3K8 is phosphorylated (Bos taurus)
ADP [cytosol]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ADP [cytosol]
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Bos taurus)
Activated TAK1 mediates phosphorylation of the IKK Complex (Bos taurus)
ADP [cytosol]
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Bos taurus)
ADP [cytosol]
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Bos taurus)
Activation of TAK1 complex bound to activated TLR4 complex (Bos taurus)
ADP [cytosol]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
IRAK1 phosphorylates Pellino (Bos taurus)
ADP [cytosol]
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Bos taurus)
ADP [cytosol]
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
ADP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ADP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
ADP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
ADP [cytosol]
MAP3K8 is phosphorylated (Bos taurus)
ADP [cytosol]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ADP [cytosol]
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Bos taurus)
Activated TAK1 mediates phosphorylation of the IKK Complex (Bos taurus)
ADP [cytosol]
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Bos taurus)
ADP [cytosol]
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
IRAK1 phosphorylates Pellino (Bos taurus)
ADP [cytosol]
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Bos taurus)
ADP [cytosol]
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
ADP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ADP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
ADP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
ADP [cytosol]
MAP3K8 is phosphorylated (Bos taurus)
ADP [cytosol]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ADP [cytosol]
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Bos taurus)
Activated TAK1 mediates phosphorylation of the IKK Complex (Bos taurus)
ADP [cytosol]
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Bos taurus)
ADP [cytosol]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Bos taurus)
ADP [cytosol]
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Bos taurus)
ADP [cytosol]
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Bos taurus)
ADP [cytosol]
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Bos taurus)
ADP [cytosol]
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Bos taurus)
ADP [cytosol]
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Bos taurus)
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Bos taurus)
ADP [cytosol]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Bos taurus)
IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation (Bos taurus)
ADP [cytosol]
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Bos taurus)
ADP [cytosol]
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
ADP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ADP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
ADP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
ADP [cytosol]
MAP3K8 is phosphorylated (Bos taurus)
ADP [cytosol]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ADP [cytosol]
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Bos taurus)
Activated TAK1 mediates phosphorylation of the IKK Complex (Bos taurus)
ADP [cytosol]
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Bos taurus)
ADP [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Bos taurus)
ADP [cytosol]
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Bos taurus)
ADP [cytosol]
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Bos taurus)
ADP [cytosol]
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Bos taurus)
ADP [cytosol]
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Bos taurus)
ADP [cytosol]
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Bos taurus)
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Bos taurus)
ADP [cytosol]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Bos taurus)
IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation (Bos taurus)
ADP [cytosol]
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Bos taurus)
ADP [cytosol]
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
ADP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
ADP [cytosol]
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
ADP [cytosol]
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
ADP [cytosol]
MAP3K8 is phosphorylated (Bos taurus)
ADP [cytosol]
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ADP [cytosol]
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Bos taurus)
Activated TAK1 mediates phosphorylation of the IKK Complex (Bos taurus)
ADP [cytosol]
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Bos taurus)
ADP [cytosol]
Metabolism (Bos taurus)
Biological oxidations (Bos taurus)
Phase II - Conjugation of compounds (Bos taurus)
Cytosolic sulfonation of small molecules (Bos taurus)
Transport and synthesis of PAPS (Bos taurus)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Bos taurus)
ADP [cytosol]
Glutathione conjugation (Bos taurus)
Glutathione synthesis and recycling (Bos taurus)
GCL ligates L-Glu to L-Cys (Bos taurus)
ADP [cytosol]
Inositol phosphate metabolism (Bos taurus)
Synthesis of IP3 and IP4 in the cytosol (Bos taurus)
I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Bos taurus)
ADP [cytosol]
I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Bos taurus)
ADP [cytosol]
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Bos taurus)
ADP [cytosol]
I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Bos taurus)
ADP [cytosol]
Synthesis of pyrophosphates in the cytosol (Bos taurus)
1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Bos taurus)
ADP [cytosol]
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Bos taurus)
ADP [cytosol]
5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Bos taurus)
ADP [cytosol]
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Bos taurus)
ADP [cytosol]
I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Bos taurus)
ADP [cytosol]
I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Bos taurus)
ADP [cytosol]
I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Bos taurus)
ADP [cytosol]
IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Bos taurus)
ADP [cytosol]
IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Bos taurus)
ADP [cytosol]
Integration of energy metabolism (Bos taurus)
Regulation of insulin secretion (Bos taurus)
KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Bos taurus)
Mg2+:ADP [cytosol]
ADP [cytosol]
Metabolism of amino acids and derivatives (Bos taurus)
Creatine metabolism (Bos taurus)
creatine + ATP => phosphocreatine + ADP [CK octamer] (Bos taurus)
ADP [cytosol]
creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Bos taurus)
ADP [cytosol]
Glutamate and glutamine metabolism (Bos taurus)
N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Bos taurus)
ADP [cytosol]
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Bos taurus)
ADP [cytosol]
Histidine catabolism (Bos taurus)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Bos taurus)
ADP [cytosol]
Metabolism of carbohydrates (Bos taurus)
Formation of xylulose-5-phosphate (Bos taurus)
XYLB phosphorylates D-xylulose (Bos taurus)
ADP [cytosol]
Fructose metabolism (Bos taurus)
Fructose catabolism (Bos taurus)
DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Bos taurus)
ADP [cytosol]
GLYCTK phosphorylates DGA to 3PDGA (Bos taurus)
ADP [cytosol]
KHK dimer phosphorylates Fru to Fru 1-P (Bos taurus)
ADP [cytosol]
Glucose metabolism (Bos taurus)
Gluconeogenesis (Bos taurus)
ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Bos taurus)
ADP [cytosol]
Glycolysis (Bos taurus)
1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Bos taurus)
ADP [cytosol]
ADPGK:Mg2+ phosphorylates Glc to G6P (Bos taurus)
ADP [cytosol]
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Bos taurus)
ADP [cytosol]
HK1,2,3,GCK phosphorylate Glc to form G6P (Bos taurus)
ADP [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Bos taurus)
D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Bos taurus)
ADP [cytosol]
phosphoenolpyruvate + ADP => pyruvate + ATP (Bos taurus)
ADP [cytosol]
Glycogen metabolism (Bos taurus)
Glycogen breakdown (glycogenolysis) (Bos taurus)
glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Bos taurus)
ADP [cytosol]
glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Bos taurus)
ADP [cytosol]
Glycosaminoglycan metabolism (Bos taurus)
Transport and synthesis of PAPS (Bos taurus)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Bos taurus)
ADP [cytosol]
Pentose phosphate pathway (Bos taurus)
RBKS phosphorylates ribose to R5P (Bos taurus)
ADP [cytosol]
SHPK phosphorylates Sedo to Sedo7P (Bos taurus)
ADP [cytosol]
Metabolism of lipids (Bos taurus)
Fatty acid metabolism (Bos taurus)
Arachidonic acid metabolism (Bos taurus)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Bos taurus)
ALOX5 is phosphorylated by MAPKAP2 (Bos taurus)
ADP [cytosol]
Carnitine metabolism (Bos taurus)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Bos taurus)
ADP [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Bos taurus)
ADP [cytosol]
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Bos taurus)
ADP [cytosol]
Fatty acyl-CoA biosynthesis (Bos taurus)
ACLY tetramer transforms CIT to Ac-CoA (Bos taurus)
ADP [cytosol]
acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Bos taurus)
ADP [cytosol]
Metabolism of steroids (Bos taurus)
Bile acid and bile salt metabolism (Bos taurus)
Recycling of bile acids and salts (Bos taurus)
ABCB11 transports bile salts from cytosol to extracellular region (Bos taurus)
ADP [cytosol]
Transport (efflux) of bile salts by ABCC3 (MRP3) (Bos taurus)
ADP [cytosol]
Synthesis of bile acids and bile salts (Bos taurus)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Bos taurus)
ABCB11 transports bile salts from cytosol to extracellular region (Bos taurus)
ADP [cytosol]
Cholesterol biosynthesis (Bos taurus)
MVD decarboxylates MVA5PP to IPPP (Bos taurus)
ADP [cytosol]
Phospholipid metabolism (Bos taurus)
Glycerophospholipid biosynthesis (Bos taurus)
Synthesis of PC (Bos taurus)
Casein kinase II phosphorylates STARD10 (Bos taurus)
ADP [cytosol]
Cho is phosphorylated to PCho by CHK dimer (Bos taurus)
ADP [cytosol]
Synthesis of PE (Bos taurus)
ETA is phosphorylated to PETA by CHK/ETNK (Bos taurus)
ADP [cytosol]
PI Metabolism (Bos taurus)
Synthesis of PIPs at the ER membrane (Bos taurus)
PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Bos taurus)
ADP [cytosol]
Synthesis of PIPs at the Golgi membrane (Bos taurus)
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Bos taurus)
ADP [cytosol]
PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Bos taurus)
ADP [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Bos taurus)
ADP [cytosol]
Synthesis of PIPs at the early endosome membrane (Bos taurus)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Bos taurus)
ADP [cytosol]
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Bos taurus)
ADP [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Bos taurus)
ADP [cytosol]
Synthesis of PIPs at the late endosome membrane (Bos taurus)
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Bos taurus)
ADP [cytosol]
Synthesis of PIPs at the plasma membrane (Bos taurus)
BMX phosphorylates RUFY1 (Bos taurus)
ADP [cytosol]
PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Bos taurus)
ADP [cytosol]
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Bos taurus)
ADP [cytosol]
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Bos taurus)
ADP [cytosol]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Bos taurus)
ADP [cytosol]
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Bos taurus)
ADP [cytosol]
PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Bos taurus)
ADP [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Bos taurus)
ADP [cytosol]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)
ADP [cytosol]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)
ADP [cytosol]
Sphingolipid metabolism (Bos taurus)
Glycosphingolipid metabolism (Bos taurus)
CERK phosphorylates CERA to form C1P (Bos taurus)
ADP [cytosol]
Sphingolipid de novo biosynthesis (Bos taurus)
PRKD1,2,3 phosphorylates COL4A3BP-2 (Bos taurus)
ADP [cytosol]
monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Bos taurus)
ADP [cytosol]
sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Bos taurus)
ADP [cytosol]
sphingosine +ATP => sphingosine 1-phosphate + ADP (Bos taurus)
ADP [cytosol]
Triglyceride metabolism (Bos taurus)
Triglyceride biosynthesis (Bos taurus)
Conversion of Glycerol to Glycerol-3-phosphate (Bos taurus)
ADP [cytosol]
Metabolism of nucleotides (Bos taurus)
Interconversion of nucleotide di- and triphosphates (Bos taurus)
(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Bos taurus)
(d)ADP [cytosol]
ADP [cytosol]
ADP [cytosol]
(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Bos taurus)
(d)NDPs [cytosol]
ADP [cytosol]
ADP [cytosol]
(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Bos taurus)
(d)ADP [cytosol]
ADP [cytosol]
ADP [cytosol]
(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Bos taurus)
ADP [cytosol]
(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Bos taurus)
ADP [cytosol]
(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Bos taurus)
ADP [cytosol]
(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Bos taurus)
ADP [cytosol]
(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Bos taurus)
ADP [cytosol]
(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Bos taurus)
ADP [cytosol]
ADP + ADP <=> AMP + ATP [AK2] (Bos taurus)
ADP [cytosol]
AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Bos taurus)
(d)NDPs [cytosol]
ADP [cytosol]
ADP [cytosol]
AMP + ATP <=> ADP + ADP [AK2] (Bos taurus)
ADP [cytosol]
NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Bos taurus)
ADP [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Bos taurus)
ADP [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Bos taurus)
ADP [cytosol]
dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Bos taurus)
ADP [cytosol]
dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Bos taurus)
ADP [cytosol]
Nucleobase biosynthesis (Bos taurus)
Purine ribonucleoside monophosphate biosynthesis (Bos taurus)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Bos taurus)
ADP [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Bos taurus)
ADP [cytosol]
FGAM + ATP => AIR + ADP + Pi (Bos taurus)
ADP [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Bos taurus)
ADP [cytosol]
Pyrimidine biosynthesis (Bos taurus)
L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate (Bos taurus)
ADP [cytosol]
Nucleobase catabolism (Bos taurus)
Purine catabolism (Bos taurus)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Bos taurus)
ADP [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Bos taurus)
ADP [cytosol]
Pyrimidine catabolism (Bos taurus)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Bos taurus)
ADP [cytosol]
Nucleotide salvage (Bos taurus)
Purine salvage (Bos taurus)
(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Bos taurus)
ADP [cytosol]
deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Bos taurus)
ADP [cytosol]
Pyrimidine salvage (Bos taurus)
(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Bos taurus)
ADP [cytosol]
UCKL1 phosphorylates urindine, cytidine (Bos taurus)
ADP [cytosol]
cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Bos taurus)
ADP [cytosol]
cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Bos taurus)
ADP [cytosol]
thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Bos taurus)
ADP [cytosol]
Metabolism of porphyrins (Bos taurus)
Heme degradation (Bos taurus)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Bos taurus)
ADP [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of cofactors (Bos taurus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Bos taurus)
PTPS is phosphorylated by cGMP-dependant protein kinase II (Bos taurus)
ADP [cytosol]
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Bos taurus)
ABCC1 transports cytosolic Cbl to extracellular region (Bos taurus)
ADP [cytosol]
ABCD4 may transport Cbl from lysosomal lumen to cytosol (Bos taurus)
ADP [cytosol]
Metabolism of folate and pterines (Bos taurus)
Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate (Bos taurus)
ADP [cytosol]
Conversion of cytosolic THF to THF-polyglutamate (Bos taurus)
ADP [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)
ADP [cytosol]
THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate (Bos taurus)
ADP [cytosol]
Nicotinate metabolism (Bos taurus)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Bos taurus)
ADP [cytosol]
NMRK1 phosphorylates NAR to yield NAMN (Bos taurus)
ADP [cytosol]
NMRK1 phosphorylates NR to yield NMN (Bos taurus)
ADP [cytosol]
NMRK2 phosphorylates NAR to yield NAMN (Bos taurus)
ADP [cytosol]
NMRK2 phosphorylates NR to yield NMN (Bos taurus)
ADP [cytosol]
Vitamin B2 (riboflavin) metabolism (Bos taurus)
RFK:Mg2+ phosphorylates RIB (Bos taurus)
ADP [cytosol]
Vitamin B5 (pantothenate) metabolism (Bos taurus)
Coenzyme A biosynthesis (Bos taurus)
COASY phosphorylates DP-CoA (Bos taurus)
ADP [cytosol]
PANK1/3/4 phosphorylate PanK (Bos taurus)
ADP [cytosol]
PANK2 phosphorylates PanK (Bos taurus)
ADP [cytosol]
Vitamins B6 activation to pyridoxal phosphate (Bos taurus)
2xPDKX:2xZn2+ phosphorylates PDX (Bos taurus)
ADP [cytosol]
2xPDXK:2xZn2+ phosphorylates PXA (Bos taurus)
ADP [cytosol]
2xPDXK:2xZn2+ phosphorylates PXL (Bos taurus)
ADP [cytosol]
The citric acid (TCA) cycle and respiratory electron transport (Bos taurus)
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Bos taurus)
Mitochondrial Uncoupling Proteins (Bos taurus)
The proton buffering model (Bos taurus)
Protons are translocated from the intermembrane space to the matrix (Bos taurus)
Purine nucleotide [cytosol]
ADP [cytosol]
Metabolism of RNA (Bos taurus)
Nonsense-Mediated Decay (NMD) (Bos taurus)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Bos taurus)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Bos taurus)
ADP [cytosol]
Regulation of mRNA stability by proteins that bind AU-rich elements (Bos taurus)
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA (Bos taurus)
MK2 phosphorylates BRF1 (Bos taurus)
ADP [cytosol]
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Asparagine N-linked glycosylation (Bos taurus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Bos taurus)
Synthesis of substrates in N-glycan biosythesis (Bos taurus)
GDP-fucose biosynthesis (Bos taurus)
FUK phosphorylates beta-Fuc to Fuc1P (Bos taurus)
ADP [cytosol]
Sialic acid metabolism (Bos taurus)
GNE phosphorylates ManNAc to ManNAc-6-P (Bos taurus)
ADP [cytosol]
Synthesis of Dolichyl-phosphate (Bos taurus)
MVD decarboxylates MVA5PP to IPPP (Bos taurus)
ADP [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Bos taurus)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Bos taurus)
ADP [cytosol]
Transport to the Golgi and subsequent modification (Bos taurus)
ER to Golgi Anterograde Transport (Bos taurus)
COPI-mediated anterograde transport (Bos taurus)
GBF1 stimulates ARF nucleotide exchange (Bos taurus)
ADP [cytosol]
COPII-mediated vesicle transport (Bos taurus)
CSNK1D phosphorylates SEC23 (Bos taurus)
ADP [cytosol]
Carboxyterminal post-translational modifications of tubulin (Bos taurus)
TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Bos taurus)
ADP [cytosol]
TTLLs polyglutamylate tubulin (Bos taurus)
ADP [cytosol]
Gamma carboxylation, hypusine formation and arylsulfatase activation (Bos taurus)
FN3K phosphorylates ketosamines (Bos taurus)
ADP [cytosol]
FN3KRP phosphorylates PsiAm, RibAm (Bos taurus)
ADP [cytosol]
Protein folding (Bos taurus)
Chaperonin-mediated protein folding (Bos taurus)
Association of TriC/CCT with target proteins during biosynthesis (Bos taurus)
Association of CCT/TriC with sphingosine kinase 1 (Bos taurus)
CCT/TRiC:ADP [cytosol] (Bos taurus)
ADP [cytosol]
CCT/TRiC:ADP:Sphingosine kinase 1 [cytosol] (Bos taurus)
CCT/TRiC:ADP [cytosol] (Bos taurus)
ADP [cytosol]
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Bos taurus)
ATP binds G-protein beta associated TRiC/CCT (Bos taurus)
ADP [cytosol]
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Bos taurus)
CCT/TRiC:ADP [cytosol] (Bos taurus)
ADP [cytosol]
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Bos taurus)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Bos taurus)
CCT/TRiC:ADP [cytosol] (Bos taurus)
ADP [cytosol]
CK2 phosphorylates PDCL (Bos taurus)
ADP [cytosol]
PDCL binds G-protein beta and TRiC/CCT (Bos taurus)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Bos taurus)
CCT/TRiC:ADP [cytosol] (Bos taurus)
ADP [cytosol]
p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Bos taurus)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Bos taurus)
CCT/TRiC:ADP [cytosol] (Bos taurus)
ADP [cytosol]
PDCL promotes G-protein beta 5 folding (Bos taurus)
GNB5:CCT/TRiC:ADP [cytosol] (Bos taurus)
CCT/TRiC:ADP [cytosol] (Bos taurus)
ADP [cytosol]
p-S18,S19,S20,S25-PDCL:Partially folded GNB5:CCT/TRiC:ADP [cytosol] (Bos taurus)
GNB5:CCT/TRiC:ADP [cytosol] (Bos taurus)
CCT/TRiC:ADP [cytosol] (Bos taurus)
ADP [cytosol]
PDCL releases folded G-beta from TRiC/CCT (Bos taurus)
CCT/TRiC:ADP [cytosol] (Bos taurus)
ADP [cytosol]
p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta 1-4:CCT/TRiC:ADP [cytosol] (Bos taurus)
Partially folded G-protein beta 1-4:CCT/TRiC:ADP [cytosol] (Bos taurus)
CCT/TRiC:ADP [cytosol] (Bos taurus)
ADP [cytosol]
RGS proteins bind GNB5 and CCT/TRiC (Bos taurus)
GNB5:CCT/TRiC:ADP [cytosol] (Bos taurus)
CCT/TRiC:ADP [cytosol] (Bos taurus)
ADP [cytosol]
RGS7,RGS9,(RGS6,RGS11):GNB5:CCT/TRiC:ADP [plasma membrane] (Bos taurus)
GNB5:CCT/TRiC:ADP [cytosol] (Bos taurus)
CCT/TRiC:ADP [cytosol] (Bos taurus)
ADP [cytosol]
Release of GNB5:RGS dimers from CCT/TRiC (Bos taurus)
CCT/TRiC:ADP [cytosol] (Bos taurus)
ADP [cytosol]
RGS7,RGS9,(RGS6,RGS11):GNB5:CCT/TRiC:ADP [plasma membrane] (Bos taurus)
GNB5:CCT/TRiC:ADP [cytosol] (Bos taurus)
CCT/TRiC:ADP [cytosol] (Bos taurus)
ADP [cytosol]
TRiC/CCT binds unfolded G-protein beta subunit (Bos taurus)
CCT/TRiC:ADP [cytosol] (Bos taurus)
ADP [cytosol]
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Bos taurus)
CCT/TRiC:ADP [cytosol] (Bos taurus)
ADP [cytosol]
Surfactant metabolism (Bos taurus)
ABCA3 transports PC, PG from ER membrane to lamellar body (Bos taurus)
ADP [cytosol]
Translation (Bos taurus)
Eukaryotic Translation Initiation (Bos taurus)
Cap-dependent Translation Initiation (Bos taurus)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Bos taurus)
Cap-bound mRNA is activated by helicases (Bos taurus)
ADP [cytosol]
Ribosomal scanning and start codon recognition (Bos taurus)
Ribosomal scanning (Bos taurus)
ADP [cytosol]
Unfolded Protein Response (UPR) (Bos taurus)
IRE1alpha activates chaperones (Bos taurus)
IRE1 dimer autophosphorylates (Bos taurus)
ADP [cytosol]
Muscle contraction (Bos taurus)
Cardiac conduction (Bos taurus)
Ion homeostasis (Bos taurus)
ATP1A:ATP1B:FXYD exchanges Na+ for K+ (Bos taurus)
ADP [cytosol]
PRKACA phosphorylates TNNI3 (Bos taurus)
ADP [cytosol]
Smooth Muscle Contraction (Bos taurus)
ATP Hydrolysis By Myosin (Bos taurus)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Bos taurus)
ADP Bound Smooth Muscle Myosin Complex [cytosol] (Bos taurus)
ADP [cytosol]
Release Of ADP From Myosin (Bos taurus)
ADP [cytosol]
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Bos taurus)
ADP Bound Smooth Muscle Myosin Complex [cytosol] (Bos taurus)
ADP [cytosol]
Striated Muscle Contraction (Bos taurus)
ATP Hydrolysis By Myosin (Bos taurus)
ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Bos taurus)
ADP Bound Myosin Complex [cytosol] (Bos taurus)
ADP [cytosol]
Release Of ADP From Myosin (Bos taurus)
ADP [cytosol]
ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Bos taurus)
ADP Bound Myosin Complex [cytosol] (Bos taurus)
ADP [cytosol]
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter receptors and postsynaptic signal transmission (Bos taurus)
Activation of NMDA receptors and postsynaptic events (Bos taurus)
Post NMDA receptor activation events (Bos taurus)
Activation of RAC1 downstream of NMDARs (Bos taurus)
CaMKK autophosphorylates in the cytosol (Bos taurus)
ADP [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Bos taurus)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Bos taurus)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Bos taurus)
ADP [cytosol]
Programmed Cell Death (Bos taurus)
Apoptosis (Bos taurus)
Intrinsic Pathway for Apoptosis (Bos taurus)
Activation of BH3-only proteins (Bos taurus)
Activation of BIM and translocation to mitochondria (Bos taurus)
Phosphorylation of BIM by JNK (Bos taurus)
ADP [cytosol]
Activation of BMF and translocation to mitochondria (Bos taurus)
Phosphorylation of DLC2 by MAPK8 (Bos taurus)
ADP [cytosol]
Apoptotic factor-mediated response (Bos taurus)
Cytochrome c-mediated apoptotic response (Bos taurus)
Formation of apoptosome (Bos taurus)
Regulation of the apoptosome activity (Bos taurus)
APAF1 binds AVEN (Bos taurus)
APAF1:ADP [cytosol] (Bos taurus)
ADP [cytosol]
APAF1:AVEN [cytosol] (Bos taurus)
APAF1:ADP [cytosol] (Bos taurus)
ADP [cytosol]
Regulated Necrosis (Bos taurus)
RIPK1-mediated regulated necrosis (Bos taurus)
RIPK1 is phosphorylated (Bos taurus)
ADP [cytosol]
RIPK3 is phosphorylated (Bos taurus)
ADP [cytosol]
RIPK3 phosphorylates MLKL (Bos taurus)
ADP [cytosol]
Protein localization (Bos taurus)
Peroxisomal protein import (Bos taurus)
PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Bos taurus)
ADP [cytosol]
Signal Transduction (Bos taurus)
Death Receptor Signalling (Bos taurus)
TNF signaling (Bos taurus)
Regulation of TNFR1 signaling (Bos taurus)
CYLD is phosphorylated by IKK (Bos taurus)
ADP [cytosol]
p75 NTR receptor-mediated signalling (Bos taurus)
Cell death signalling via NRAGE, NRIF and NADE (Bos taurus)
NRAGE signals death through JNK (Bos taurus)
GTP-bound RAC contributes to JNK activation (Bos taurus)
ADP [cytosol]
JNK phosphorylates BIM, BAD and other targets (Bos taurus)
ADP [cytosol]
p75NTR signals via NF-kB (Bos taurus)
NF-kB is activated and signals survival (Bos taurus)
IKKbeta is activated (Bos taurus)
ADP [cytosol]
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Bos taurus)
ADP [cytosol]
Intracellular signaling by second messengers (Bos taurus)
DAG and IP3 signaling (Bos taurus)
CaM pathway (Bos taurus)
Calmodulin induced events (Bos taurus)
PKC phosphorylates GRK2 (Bos taurus)
ADP [cytosol]
DAG stimulates protein kinase C-delta (Bos taurus)
ADP [cytosol]
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)
ADP [cytosol]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)
ADP [cytosol]
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
PTEN Regulation (Bos taurus)
Regulation of PTEN gene transcription (Bos taurus)
mTORC1 phosphorylates MAF1 (Bos taurus)
ADP [cytosol]
Regulation of PTEN stability and activity (Bos taurus)
Casein kinase II phosphorylates PTEN (Bos taurus)
ADP [cytosol]
FRK phosphorylates PTEN (Bos taurus)
ADP [cytosol]
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF-independent MAPK1/3 activation (Bos taurus)
MAPK1 (ERK2) activation (Bos taurus)
MAP2K2 phosphorylates MAPK1 (Bos taurus)
ADP [cytosol]
MAPK3 (ERK1) activation (Bos taurus)
Inactivation of MAP2K1 by CDK1 (Bos taurus)
ADP [cytosol]
MAP2K1 phosphorylates MAPK3 (Bos taurus)
ADP [cytosol]
RAF/MAP kinase cascade (Bos taurus)
MAP2K and MAPK activation (Bos taurus)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Bos taurus)
ADP [cytosol]
MAP2Ks phosphorylate MAPK at the Golgi membrane (Bos taurus)
ADP [cytosol]
MAP2Ks phosphorylate MAPKs (Bos taurus)
ADP [cytosol]
RAF phosphorylates MAP2K dimer (Bos taurus)
ADP [cytosol]
Negative regulation of MAPK pathway (Bos taurus)
Negative feedback regulation of MAPK pathway (Bos taurus)
Activated MAPK phosphorylates RAF1 (Bos taurus)
ADP [cytosol]
Activated MAPKs phosphorylate BRAF (Bos taurus)
ADP [cytosol]
Activated MAPKs phosphorylate MAP2K1 (Bos taurus)
ADP [cytosol]
RAF activation (Bos taurus)
MARK3 phosphorylates KSR1 (Bos taurus)
ADP [cytosol]
Phosphorylation of RAF (Bos taurus)
ADP [cytosol]
MAPK6/MAPK4 signaling (Bos taurus)
Autophosphorylation of PAK1,2,3 (Bos taurus)
ADP [cytosol]
MAPKAPK5 phosphorylates KALRN (Bos taurus)
ADP [cytosol]
PAK1,2,3 phosphorylates MAPK6,4 (Bos taurus)
ADP [cytosol]
p-T182 MAPKAPK5 phosphorylates FOXO3 (Bos taurus)
ADP [cytosol]
p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Bos taurus)
ADP [cytosol]
Signaling by Erythropoietin (Bos taurus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Bos taurus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Bos taurus)
ADP [cytosol]
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Bos taurus)
ADP [cytosol]
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Bos taurus)
ADP [cytosol]
Opioid Signalling (Bos taurus)
DARPP-32 events (Bos taurus)
PKA phosphorylates DARPP-32 on Thr34 (Bos taurus)
ADP [cytosol]
PKA phosphorylates PDE4B (Bos taurus)
ADP [cytosol]
G-protein mediated events (Bos taurus)
PLC beta mediated events (Bos taurus)
Ca-dependent events (Bos taurus)
CaM pathway (Bos taurus)
Calmodulin induced events (Bos taurus)
PKC phosphorylates GRK2 (Bos taurus)
ADP [cytosol]
phospho-PLA2 pathway (Bos taurus)
Phosphorylation of cPLA2 by ERK-2 (Bos taurus)
ADP [cytosol]
Visual phototransduction (Bos taurus)
The canonical retinoid cycle in rods (twilight vision) (Bos taurus)
ABCA4 mediates atRAL transport (Bos taurus)
ADP [cytosol]
The phototransduction cascade (Bos taurus)
Inactivation, recovery and regulation of the phototransduction cascade (Bos taurus)
GRK1,4,7 phosphorylate MII to p-MII (Bos taurus)
ADP [cytosol]
G alpha (q) signalling events (Bos taurus)
Effects of PIP2 hydrolysis (Bos taurus)
DAG kinase produces phosphatidic acid from DAG (Bos taurus)
ADP [cytosol]
G alpha (s) signalling events (Bos taurus)
ADRB2 in ADRB2:GRK complex is phosphorylated (Bos taurus)
ADP [cytosol]
G-protein beta:gamma signalling (Bos taurus)
G beta:gamma signalling through PI3Kgamma (Bos taurus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
Signaling by Hedgehog (Bos taurus)
Hedgehog 'off' state (Bos taurus)
GLI3 is processed to GLI3R by the proteasome (Bos taurus)
CK1 phosphorylates p-GLI3 (Bos taurus)
ADP [cytosol]
GSK3 phosphorylates p-GLI3 (Bos taurus)
![ADP [cytosol] icon](/icon/R-ICO-012397.svg){kind=icon}