Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
ADP [cytosol]
Stable Identifier
R-ALL-29370
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
Adenosine 5'-diphosphate, ADP(3-)
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Mycobacterium tuberculosis
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Autophagy (Bos taurus)
Macroautophagy (Bos taurus)
Active MTORC1 phosphorylates ULK1 (Bos taurus)
ADP [cytosol]
Selective autophagy (Bos taurus)
Mitophagy (Bos taurus)
Receptor Mediated Mitophagy (Bos taurus)
p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Bos taurus)
ADP [cytosol]
p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Bos taurus)
ADP [cytosol]
Cell Cycle (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
M Phase (Bos taurus)
Mitotic Prophase (Bos taurus)
Golgi Cisternae Pericentriolar Stack Reorganization (Bos taurus)
PLK1 phosphorylates GORASP1 (Bos taurus)
ADP [cytosol]
Nuclear Envelope Breakdown (Bos taurus)
Activation of NIMA Kinases NEK9, NEK6, NEK7 (Bos taurus)
NEK9 phosphorylates NEK6/NEK7 (Bos taurus)
ADP [cytosol]
Mitotic G1 phase and G1/S transition (Bos taurus)
G1 Phase (Bos taurus)
Cyclin D associated events in G1 (Bos taurus)
Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Bos taurus)
ADP [cytosol]
G1/S Transition (Bos taurus)
Cyclin E associated events during G1/S transition (Bos taurus)
SCF(Skp2)-mediated degradation of p27/p21 (Bos taurus)
PTK6 phosphorylates CDKN1B (Bos taurus)
ADP [cytosol]
Mitotic G2-G2/M phases (Bos taurus)
G2/M Transition (Bos taurus)
Interaction between PHLDA1 and AURKA (Bos taurus)
AURKA phosphorylates PHLDA1 (Bos taurus)
ADP [cytosol]
S Phase (Bos taurus)
Cyclin A:Cdk2-associated events at S phase entry (Bos taurus)
SCF(Skp2)-mediated degradation of p27/p21 (Bos taurus)
PTK6 phosphorylates CDKN1B (Bos taurus)
ADP [cytosol]
Cellular responses to external stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular Senescence (Bos taurus)
Oxidative Stress Induced Senescence (Bos taurus)
MAP3K5 phosphorylates MKK3 and MKK6 (Bos taurus)
ADP [cytosol]
Cellular response to heat stress (Bos taurus)
Regulation of HSF1-mediated heat shock response (Bos taurus)
HSP110s exchange ATP for ADP on HSP70s:ADP (Bos taurus)
ADP [cytosol]
HSP70s:ADP [cytosol] (Bos taurus)
HSP13:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSP14:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA12B:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA1A:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA1L:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA4:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA4L:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA6:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA7:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA9:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Bos taurus)
HSP70s:ADP [cytosol] (Bos taurus)
HSP13:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSP14:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA12B:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA1A:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA1L:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA4:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA4L:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA6:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA7:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSPA9:ADP [cytosol] (Bos taurus)
ADP [cytosol]
HSP90 chaperone cycle for steroid hormone receptors (SHR) (Bos taurus)
ATP hydrolysis by HSP70 (Bos taurus)
HSP40:HSP70:ADP:nascent protein [cytosol] (Bos taurus)
ADP [cytosol]
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
EPH-Ephrin signaling (Bos taurus)
EPH receptors autophosphorylate (Bos taurus)
ADP [cytosol]
EPH-ephrin mediated repulsion of cells (Bos taurus)
SFKs phosphorylate VAV2,3 (Bos taurus)
ADP [cytosol]
Ephrin signaling (Bos taurus)
PAKs autophosphorylate (Bos taurus)
ADP [cytosol]
PAKs phosphorylate MLC (Bos taurus)
ADP [cytosol]
RET signaling (Bos taurus)
GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Bos taurus)
ADP [cytosol]
RET tyrosine phosphorylation (Bos taurus)
ADP [cytosol]
Semaphorin interactions (Bos taurus)
CRMPs in Sema3A signaling (Bos taurus)
Phosphorylation of CRMPs by Cdk5 (Bos taurus)
ADP [cytosol]
Phosphorylation of CRMPs by GSK3beta (Bos taurus)
ADP [cytosol]
Tyrosine phosphorylation of CRMPs by Fes (Bos taurus)
ADP [cytosol]
Sema3A PAK dependent Axon repulsion (Bos taurus)
Autophosphorylation of PAK (Bos taurus)
ADP [cytosol]
Phosphorylation of LIMK-1 by PAK (Bos taurus)
ADP [cytosol]
Signaling by ROBO receptors (Bos taurus)
Role of ABL in ROBO-SLIT signaling (Bos taurus)
Phosphorylation of ROBO1 by ABL kinase (Bos taurus)
ADP [cytosol]
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional Regulation by TP53 (Bos taurus)
TP53 Regulates Transcription of Cell Cycle Genes (Bos taurus)
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Bos taurus)
PLK2 phosphorylates NPM1 (Bos taurus)
ADP [cytosol]
Transcriptional regulation by RUNX3 (Bos taurus)
Regulation of RUNX3 expression and activity (Bos taurus)
SRC phosphorylates RUNX3 (Bos taurus)
ADP [cytosol]
Hemostasis (Bos taurus)
Cell surface interactions at the vascular wall (Bos taurus)
PECAM1 interactions (Bos taurus)
Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Bos taurus)
ADP [cytosol]
Platelet activation, signaling and aggregation (Bos taurus)
Effects of PIP2 hydrolysis (Bos taurus)
DAG kinase produces phosphatidic acid from DAG (Bos taurus)
ADP [cytosol]
GPVI-mediated activation cascade (Bos taurus)
Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Bos taurus)
ADP [cytosol]
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
SYK autophosphorylates (Bos taurus)
ADP [cytosol]
Response to elevated platelet cytosolic Ca2+ (Bos taurus)
Platelet degranulation (Bos taurus)
ABCC4 accumulation of dense granule contents (Bos taurus)
ADP [cytosol]
Signal amplification (Bos taurus)
ADP signalling through P2Y purinoceptor 1 (Bos taurus)
P2Y purinoceptor 1 activates MAP kinase p38 alpha (Bos taurus)
ADP [cytosol]
Platelet homeostasis (Bos taurus)
Platelet sensitization by LDL (Bos taurus)
Fgr may phosphorylate p38 MAPK (Bos taurus)
ADP [cytosol]
PECAM1 is phosphorylated (Bos taurus)
ADP [cytosol]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Bos taurus)
Transport of Antigen peptide in to ER (Bos taurus)
ADP [cytosol]
Costimulation by the CD28 family (Bos taurus)
CD28 co-stimulation (Bos taurus)
CD28 dependent PI3K/Akt signaling (Bos taurus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
p-S400-Cot phosphorylates NIK (Bos taurus)
ADP [cytosol]
CD28 dependent Vav1 pathway (Bos taurus)
Activation of Vav1 (Bos taurus)
ADP [cytosol]
Phosphorylation of CD28 (Bos taurus)
ADP [cytosol]
CTLA4 inhibitory signaling (Bos taurus)
Phosphorylation of CTLA-4 (Bos taurus)
ADP [cytosol]
Rap1 signalling (Bos taurus)
PKA/PKG phosphorylate Rap1GAP2 (Bos taurus)
ADP [cytosol]
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
Phosphorylation of Bcl10 (Bos taurus)
ADP [cytosol]
Phosphorylation of CARMA1 (Bos taurus)
ADP [cytosol]
Phosphorylation of PKC theta (Bos taurus)
ADP [cytosol]
Cytokine Signaling in Immune system (Bos taurus)
FLT3 Signaling (Bos taurus)
Active FLT3 phosphorylates CDKN1B (Bos taurus)
ADP [cytosol]
FLT3 phosphorylates GRB10 (Bos taurus)
ADP [cytosol]
FLT3LG dimer:FLT3 dimer autophosphorylates (Bos taurus)
ADP [cytosol]
Negative regulation of FLT3 (Bos taurus)
FLT3 phosphorylates CBL (Bos taurus)
ADP [cytosol]
Growth hormone receptor signaling (Bos taurus)
JAK2 phosphorylation (Bos taurus)
ADP [cytosol]
Interferon Signaling (Bos taurus)
Interferon alpha/beta signaling (Bos taurus)
Activation of JAK kinases (Bos taurus)
ADP [cytosol]
Formation of p-STAT1 homodimer (Bos taurus)
ADP [cytosol]
Phosphorylation of INFAR1 by TYK2 (Bos taurus)
ADP [cytosol]
Phosphorylation of STAT1 (Bos taurus)
ADP [cytosol]
Phosphorylation of STAT2 (Bos taurus)
ADP [cytosol]
Interferon gamma signaling (Bos taurus)
Phosphorylation of IFNGR1 by JAK kinases (Bos taurus)
ADP [cytosol]
Phosphorylation of JAK2 (Bos taurus)
ADP [cytosol]
Phosphorylation of STAT1 at Ser727 (Bos taurus)
ADP [cytosol]
Phosphorylation of STAT1 by JAK kinases (Bos taurus)
ADP [cytosol]
Transphosphorylation of JAK1 (Bos taurus)
ADP [cytosol]
Prolactin receptor signaling (Bos taurus)
JAK2 phosphorylation (Bos taurus)
ADP [cytosol]
PRLR is phosphorylated at Ser-349 (Bos taurus)
ADP [cytosol]
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 signaling (Bos taurus)
IKBA is phosphorylated by Phospho IKKB kinase (Bos taurus)
ADP [cytosol]
hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Bos taurus)
ADP [cytosol]
Interleukin-37 signaling (Bos taurus)
TBK1 phosphorylation (Bos taurus)
ADP [cytosol]
Interleukin-38 signaling (Bos taurus)
MAPK8 phosphorylation (Bos taurus)
ADP [cytosol]
Interleukin-12 family signaling (Bos taurus)
Interleukin-23 signaling (Bos taurus)
STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Bos taurus)
ADP [cytosol]
Interleukin-27 signaling (Bos taurus)
IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Bos taurus)
ADP [cytosol]
JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Bos taurus)
ADP [cytosol]
STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Bos taurus)
ADP [cytosol]
Interleukin-35 Signalling (Bos taurus)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Bos taurus)
ADP [cytosol]
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Bos taurus)
ADP [cytosol]
Interleukin-17 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ADP [cytosol]
Interleukin-2 family signaling (Bos taurus)
Interleukin receptor SHC signaling (Bos taurus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Bos taurus)
ADP [cytosol]
Interleukin-15 signaling (Bos taurus)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Bos taurus)
ADP [cytosol]
Interleukin-20 family signaling (Bos taurus)
IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Bos taurus)
ADP [cytosol]
IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Bos taurus)
ADP [cytosol]
IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Bos taurus)
ADP [cytosol]
IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Bos taurus)
ADP [cytosol]
IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Bos taurus)
ADP [cytosol]
IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Bos taurus)
ADP [cytosol]
IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Bos taurus)
ADP [cytosol]
JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Bos taurus)
ADP [cytosol]
Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
Activation of STAT5a/b by JAK2 (Bos taurus)
ADP [cytosol]
Interleukin receptor SHC signaling (Bos taurus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Bos taurus)
ADP [cytosol]
JAK2 is phosphorylated, activated (Bos taurus)
ADP [cytosol]
Tyrosine kinases phosphorylate the receptor (Bos taurus)
ADP [cytosol]
Interleukin-6 family signaling (Bos taurus)
Interleukin-6 signaling (Bos taurus)
IL6ST is tyrosine phosphorylated (Bos taurus)
ADP [cytosol]
JAK activation (Bos taurus)
ADP [cytosol]
PTPN11 is phosphorylated (Bos taurus)
ADP [cytosol]
Serine phosphorylation of STATs (Bos taurus)
ADP [cytosol]
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Bos taurus)
ADP [cytosol]
Interleukin-7 signaling (Bos taurus)
STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Bos taurus)
ADP [cytosol]
TNFR2 non-canonical NF-kB pathway (Bos taurus)
NIK-->noncanonical NF-kB signaling (Bos taurus)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Bos taurus)
ADP [cytosol]
NIK autophosphorylates on T559 (Bos taurus)
ADP [cytosol]
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
Dectin-1 mediated noncanonical NF-kB signaling (Bos taurus)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Bos taurus)
ADP [cytosol]
PKC-delta phosphorylates CARD9 (Bos taurus)
ADP [cytosol]
SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Bos taurus)
ADP [cytosol]
Dectin-2 family (Bos taurus)
LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Bos taurus)
ADP [cytosol]
SYK autophosphorylates (Bos taurus)
ADP [cytosol]
SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Bos taurus)
ADP [cytosol]
Cytosolic sensors of pathogen-associated DNA (Bos taurus)
STING mediated induction of host immune responses (Bos taurus)
IRF3-mediated induction of type I IFN (Bos taurus)
IRF3 is phosphorylated by TBK1 (Bos taurus)
ADP [cytosol]
TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Bos taurus)
ADP [cytosol]
STAT6-mediated induction of chemokines (Bos taurus)
TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Bos taurus)
ADP [cytosol]
TBK1 phosphorylates STAT6 at Ser407 (Bos taurus)
ADP [cytosol]
p-S407-STAT6 is phosphorylated at Tyr641 (Bos taurus)
ADP [cytosol]
DAP12 interactions (Bos taurus)
DAP12 signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
Phosphorylation of SYK (Bos taurus)
ADP [cytosol]
Fc epsilon receptor (FCERI) signaling (Bos taurus)
Autophosphorylation of LYN kinase (Bos taurus)
ADP [cytosol]
FCERI mediated Ca+2 mobilization (Bos taurus)
Autophosphorylation of BTK/ITK (Bos taurus)
ADP [cytosol]
FCERI mediated MAPK activation (Bos taurus)
Phosphorylation and activation of VAV (Bos taurus)
ADP [cytosol]
FCERI mediated NF-kB activation (Bos taurus)
Activation of TAK1 complex bound to pUb-TRAF6 (Bos taurus)
ADP [cytosol]
Autophosphorylation of PKC-theta (Bos taurus)
ADP [cytosol]
Phosphorylation of CARMA1 by PKC-theta (Bos taurus)
ADP [cytosol]
Role of LAT2/NTAL/LAB on calcium mobilization (Bos taurus)
Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)
ADP [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
Branching and elongation of mother and daughter filaments (Bos taurus)
Mother filament:ARP2/3:actin:ADP [cytosol] (Bos taurus)
Actin:ADP [cytosol] (Bos taurus)
ADP [cytosol]
PAK1 phosphorylates LIMK1 (Bos taurus)
ADP [cytosol]
Role of phospholipids in phagocytosis (Bos taurus)
DAG stimulates protein kinase C-delta (Bos taurus)
ADP [cytosol]
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ADP [cytosol]
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ADP [cytosol]
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ADP [cytosol]
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
MAP kinase activation (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ADP [cytosol]
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF(TICAM1)-mediated TLR4 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ADP [cytosol]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ADP [cytosol]
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ADP [cytosol]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
MAP kinase activation (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ADP [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
MAP kinase activation (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
ADP [cytosol]
Metabolism (Bos taurus)
Biological oxidations (Bos taurus)
Phase II - Conjugation of compounds (Bos taurus)
Cytosolic sulfonation of small molecules (Bos taurus)
Transport and synthesis of PAPS (Bos taurus)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Bos taurus)
ADP [cytosol]
Glutathione conjugation (Bos taurus)
Glutathione synthesis and recycling (Bos taurus)
GCL ligates L-Glu to L-Cys (Bos taurus)
ADP [cytosol]
Inositol phosphate metabolism (Bos taurus)
Synthesis of IP3 and IP4 in the cytosol (Bos taurus)
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Bos taurus)
ADP [cytosol]
Synthesis of pyrophosphates in the cytosol (Bos taurus)
1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Bos taurus)
ADP [cytosol]
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Bos taurus)
ADP [cytosol]
5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Bos taurus)
ADP [cytosol]
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Bos taurus)
ADP [cytosol]
I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Bos taurus)
ADP [cytosol]
I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Bos taurus)
ADP [cytosol]
IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Bos taurus)
ADP [cytosol]
IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Bos taurus)
ADP [cytosol]
Integration of energy metabolism (Bos taurus)
Regulation of insulin secretion (Bos taurus)
KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Bos taurus)
Mg2+:ADP [cytosol]
ADP [cytosol]
Metabolism of amino acids and derivatives (Bos taurus)
Creatine metabolism (Bos taurus)
creatine + ATP => phosphocreatine + ADP [CK octamer] (Bos taurus)
ADP [cytosol]
creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Bos taurus)
ADP [cytosol]
Glutamate and glutamine metabolism (Bos taurus)
N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Bos taurus)
ADP [cytosol]
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Bos taurus)
ADP [cytosol]
Histidine catabolism (Bos taurus)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Bos taurus)
ADP [cytosol]
Metabolism of carbohydrates (Bos taurus)
Fructose metabolism (Bos taurus)
Fructose catabolism (Bos taurus)
DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Bos taurus)
ADP [cytosol]
KHK dimer phosphorylates Fru to Fru 1-P (Bos taurus)
ADP [cytosol]
Glucose metabolism (Bos taurus)
Glycolysis (Bos taurus)
ADPGK:Mg2+ phosphorylates Glc to G6P (Bos taurus)
ADP [cytosol]
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Bos taurus)
ADP [cytosol]
phosphoenolpyruvate + ADP => pyruvate + ATP (Bos taurus)
ADP [cytosol]
Glycosaminoglycan metabolism (Bos taurus)
Transport and synthesis of PAPS (Bos taurus)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Bos taurus)
ADP [cytosol]
Pentose phosphate pathway (Bos taurus)
RBKS phosphorylates ribose to R5P (Bos taurus)
ADP [cytosol]
SHPK phosphorylates Sedo to Sedo7P (Bos taurus)
ADP [cytosol]
Metabolism of lipids (Bos taurus)
Metabolism of steroids (Bos taurus)
Cholesterol biosynthesis (Bos taurus)
MVD decarboxylates MVA5PP to IPPP (Bos taurus)
ADP [cytosol]
Phospholipid metabolism (Bos taurus)
Glycerophospholipid biosynthesis (Bos taurus)
Synthesis of PC (Bos taurus)
Cho is phosphorylated to PCho by CHK dimer (Bos taurus)
ADP [cytosol]
Synthesis of PE (Bos taurus)
ETA is phosphorylated to PETA by CHK/ETNK (Bos taurus)
ADP [cytosol]
PI Metabolism (Bos taurus)
Synthesis of PIPs at the ER membrane (Bos taurus)
PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Bos taurus)
ADP [cytosol]
Synthesis of PIPs at the Golgi membrane (Bos taurus)
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Bos taurus)
ADP [cytosol]
PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Bos taurus)
ADP [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Bos taurus)
ADP [cytosol]
Synthesis of PIPs at the early endosome membrane (Bos taurus)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Bos taurus)
ADP [cytosol]
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Bos taurus)
ADP [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Bos taurus)
ADP [cytosol]
Synthesis of PIPs at the late endosome membrane (Bos taurus)
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Bos taurus)
ADP [cytosol]
Synthesis of PIPs at the plasma membrane (Bos taurus)
BMX phosphorylates RUFY1 (Bos taurus)
ADP [cytosol]
PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Bos taurus)
ADP [cytosol]
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Bos taurus)
ADP [cytosol]
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Bos taurus)
ADP [cytosol]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Bos taurus)
ADP [cytosol]
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Bos taurus)
ADP [cytosol]
PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Bos taurus)
ADP [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Bos taurus)
ADP [cytosol]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)
ADP [cytosol]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)
ADP [cytosol]
Sphingolipid metabolism (Bos taurus)
Glycosphingolipid metabolism (Bos taurus)
CERK phosphorylates CERA to form C1P (Bos taurus)
ADP [cytosol]
Sphingolipid de novo biosynthesis (Bos taurus)
PRKD1,2,3 phosphorylates COL4A3BP-2 (Bos taurus)
ADP [cytosol]
SPHK2 phosphorylates SPG to S1P (Bos taurus)
ADP [cytosol]
monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Bos taurus)
ADP [cytosol]
sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Bos taurus)
ADP [cytosol]
Triglyceride metabolism (Bos taurus)
Triglyceride biosynthesis (Bos taurus)
Conversion of Glycerol to Glycerol-3-phosphate (Bos taurus)
ADP [cytosol]
Metabolism of nucleotides (Bos taurus)
Interconversion of nucleotide di- and triphosphates (Bos taurus)
(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Bos taurus)
(d)NDPs [cytosol]
ADP [cytosol]
ADP [cytosol]
(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Bos taurus)
ADP [cytosol]
(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Bos taurus)
ADP [cytosol]
ADP + ADP <=> AMP + ATP [AK2] (Bos taurus)
ADP [cytosol]
AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Bos taurus)
(d)NDPs [cytosol]
ADP [cytosol]
ADP [cytosol]
AMP + ATP <=> ADP + ADP [AK2] (Bos taurus)
ADP [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Bos taurus)
ADP [cytosol]
dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Bos taurus)
ADP [cytosol]
dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Bos taurus)
ADP [cytosol]
Nucleobase biosynthesis (Bos taurus)
Purine ribonucleoside monophosphate biosynthesis (Bos taurus)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Bos taurus)
ADP [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Bos taurus)
ADP [cytosol]
FGAM + ATP => AIR + ADP + Pi (Bos taurus)
ADP [cytosol]
Pyrimidine biosynthesis (Bos taurus)
L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate (Bos taurus)
ADP [cytosol]
Nucleobase catabolism (Bos taurus)
Purine catabolism (Bos taurus)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Bos taurus)
ADP [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Bos taurus)
ADP [cytosol]
Pyrimidine catabolism (Bos taurus)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Bos taurus)
ADP [cytosol]
Nucleotide salvage (Bos taurus)
Purine salvage (Bos taurus)
(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Bos taurus)
ADP [cytosol]
deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Bos taurus)
ADP [cytosol]
Pyrimidine salvage (Bos taurus)
(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Bos taurus)
ADP [cytosol]
UCKL1 phosphorylates urindine, cytidine (Bos taurus)
ADP [cytosol]
cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Bos taurus)
ADP [cytosol]
cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Bos taurus)
ADP [cytosol]
thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Bos taurus)
ADP [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of cofactors (Bos taurus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Bos taurus)
PTPS is phosphorylated by cGMP-dependant protein kinase II (Bos taurus)
ADP [cytosol]
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Metabolism of folate and pterines (Bos taurus)
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)
ADP [cytosol]
Nicotinate metabolism (Bos taurus)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Bos taurus)
ADP [cytosol]
NMRK1 phosphorylates NAR to yield NAMN (Bos taurus)
ADP [cytosol]
NMRK1 phosphorylates NR to yield NMN (Bos taurus)
ADP [cytosol]
NMRK2 phosphorylates NAR to yield NAMN (Bos taurus)
ADP [cytosol]
NMRK2 phosphorylates NR to yield NMN (Bos taurus)
ADP [cytosol]
Vitamin B2 (riboflavin) metabolism (Bos taurus)
RFK:Mg2+ phosphorylates RIB (Bos taurus)
ADP [cytosol]
Vitamin B5 (pantothenate) metabolism (Bos taurus)
Coenzyme A biosynthesis (Bos taurus)
COASY phosphorylates DP-CoA (Bos taurus)
ADP [cytosol]
Vitamins B6 activation to pyridoxal phosphate (Bos taurus)
2xPDKX:2xZn2+ phosphorylates PDX (Bos taurus)
ADP [cytosol]
2xPDXK:2xZn2+ phosphorylates PXA (Bos taurus)
ADP [cytosol]
2xPDXK:2xZn2+ phosphorylates PXL (Bos taurus)
ADP [cytosol]
The citric acid (TCA) cycle and respiratory electron transport (Bos taurus)
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Bos taurus)
Mitochondrial Uncoupling (Bos taurus)
The proton buffering model (Bos taurus)
Protons are translocated from the intermembrane space to the matrix (Bos taurus)
Purine nucleotide [cytosol]
ADP [cytosol]
Metabolism of RNA (Bos taurus)
Nonsense-Mediated Decay (NMD) (Bos taurus)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Bos taurus)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Bos taurus)
ADP [cytosol]
Regulation of mRNA stability by proteins that bind AU-rich elements (Bos taurus)
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA (Bos taurus)
MK2 phosphorylates BRF1 (Bos taurus)
ADP [cytosol]
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Asparagine N-linked glycosylation (Bos taurus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Bos taurus)
Synthesis of substrates in N-glycan biosythesis (Bos taurus)
GDP-fucose biosynthesis (Bos taurus)
FUK phosphorylates beta-Fuc to Fuc1P (Bos taurus)
ADP [cytosol]
Sialic acid metabolism (Bos taurus)
GNE phosphorylates ManNAc to ManNAc-6-P (Bos taurus)
ADP [cytosol]
Synthesis of Dolichyl-phosphate (Bos taurus)
MVD decarboxylates MVA5PP to IPPP (Bos taurus)
ADP [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Bos taurus)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Bos taurus)
ADP [cytosol]
Transport to the Golgi and subsequent modification (Bos taurus)
ER to Golgi Anterograde Transport (Bos taurus)
COPI-mediated anterograde transport (Bos taurus)
GBF1 stimulates ARF nucleotide exchange (Bos taurus)
ADP [cytosol]
Gamma carboxylation, hypusine formation and arylsulfatase activation (Bos taurus)
FN3KRP phosphorylates PsiAm, RibAm (Bos taurus)
ADP [cytosol]
Surfactant metabolism (Bos taurus)
ABCA3 transports PC, PG from ER membrane to lamellar body (Bos taurus)
ADP [cytosol]
Unfolded Protein Response (UPR) (Bos taurus)
IRE1alpha activates chaperones (Bos taurus)
IRE1 dimer autophosphorylates (Bos taurus)
ADP [cytosol]
Muscle contraction (Bos taurus)
Cardiac conduction (Bos taurus)
Ion homeostasis (Bos taurus)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Bos taurus)
ADP [cytosol]
Striated Muscle Contraction (Bos taurus)
ATP Hydrolysis By Myosin (Bos taurus)
ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Bos taurus)
ADP Bound Myosin Complex [cytosol] (Bos taurus)
ADP [cytosol]
Release Of ADP From Myosin (Bos taurus)
ADP [cytosol]
ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Bos taurus)
ADP Bound Myosin Complex [cytosol] (Bos taurus)
ADP [cytosol]
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter receptors and postsynaptic signal transmission (Bos taurus)
Activation of NMDA receptors and postsynaptic events (Bos taurus)
Post NMDA receptor activation events (Bos taurus)
Activation of RAC1 downstream of NMDARs (Bos taurus)
CaMKK autophosphorylates in the cytosol (Bos taurus)
ADP [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Bos taurus)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Bos taurus)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Bos taurus)
ADP [cytosol]
Programmed Cell Death (Bos taurus)
Apoptosis (Bos taurus)
Intrinsic Pathway for Apoptosis (Bos taurus)
Activation of BH3-only proteins (Bos taurus)
Activation of BIM and translocation to mitochondria (Bos taurus)
Phosphorylation of BIM by JNK (Bos taurus)
ADP [cytosol]
Activation of BMF and translocation to mitochondria (Bos taurus)
Phosphorylation of DLC2 by MAPK8 (Bos taurus)
ADP [cytosol]
Regulated Necrosis (Bos taurus)
RIPK1-mediated regulated necrosis (Bos taurus)
RIPK1 is phosphorylated (Bos taurus)
ADP [cytosol]
RIPK3 is phosphorylated (Bos taurus)
ADP [cytosol]
RIPK3 phosphorylates MLKL (Bos taurus)
ADP [cytosol]
Signal Transduction (Bos taurus)
Death Receptor Signalling (Bos taurus)
p75 NTR receptor-mediated signalling (Bos taurus)
Cell death signalling via NRAGE, NRIF and NADE (Bos taurus)
NRAGE signals death through JNK (Bos taurus)
JNK phosphorylates BIM, BAD and other targets (Bos taurus)
ADP [cytosol]
Intracellular signaling by second messengers (Bos taurus)
DAG and IP3 signaling (Bos taurus)
DAG stimulates protein kinase C-delta (Bos taurus)
ADP [cytosol]
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)
ADP [cytosol]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)
ADP [cytosol]
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
MAP2K and MAPK activation (Bos taurus)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Bos taurus)
ADP [cytosol]
MAP2Ks phosphorylate MAPK at the Golgi membrane (Bos taurus)
ADP [cytosol]
MAP2Ks phosphorylate MAPKs (Bos taurus)
ADP [cytosol]
RAF phosphorylates MAP2K dimer (Bos taurus)
ADP [cytosol]
RAF activation (Bos taurus)
MARK3 phosphorylates KSR1 (Bos taurus)
ADP [cytosol]
Phosphorylation of RAF (Bos taurus)
ADP [cytosol]
MAPK6/MAPK4 signaling (Bos taurus)
MAPKAPK5 phosphorylates KALRN (Bos taurus)
ADP [cytosol]
PAK1,2,3 phosphorylates MAPK6,4 (Bos taurus)
ADP [cytosol]
p-T182 MAPKAPK5 phosphorylates FOXO3 (Bos taurus)
ADP [cytosol]
p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Bos taurus)
ADP [cytosol]
MTOR signalling (Bos taurus)
Energy dependent regulation of mTOR by LKB1-AMPK (Bos taurus)
AMPK phosphorylates Raptor in the mTORC1 complex (Bos taurus)
ADP [cytosol]
mTORC1 phosphorylates AKT1S1 (Bos taurus)
ADP [cytosol]
mTORC1-mediated signalling (Bos taurus)
Phosphorylation and inactivation of eEF2K by activated S6K1 (Bos taurus)
ADP [cytosol]
Phosphorylation of 4E-BP1 by activated mTORC1 (Bos taurus)
ADP [cytosol]
Phosphorylation of Ribosomal protein S6 by activated S6K1 (Bos taurus)
ADP [cytosol]
mTORC1 phosphorylation of RPS6KB1 (S6K) (Bos taurus)
ADP [cytosol]
Signaling by Erythropoietin (Bos taurus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Bos taurus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Bos taurus)
ADP [cytosol]
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC (Bos taurus)
ADP [cytosol]
G alpha (q) signalling events (Bos taurus)
Effects of PIP2 hydrolysis (Bos taurus)
DAG kinase produces phosphatidic acid from DAG (Bos taurus)
ADP [cytosol]
G alpha (s) signalling events (Bos taurus)
ADRB2 in ADRB2:GRK complex is phosphorylated (Bos taurus)
ADP [cytosol]
G-protein beta:gamma signalling (Bos taurus)
G beta:gamma signalling through PI3Kgamma (Bos taurus)
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
Signaling by Hippo (Bos taurus)
Phosphorylation of WWTR1 (TAZ) by LATS1 (Bos taurus)
ADP [cytosol]
Phosphorylation of WWTR1 (TAZ) by LATS2 (Bos taurus)
ADP [cytosol]
Phosphorylation of YAP by LATS1 (Bos taurus)
ADP [cytosol]
Phosphorylation of YAP by LATS2 (Bos taurus)
ADP [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Bos taurus)
Signaling by PTK6 (Bos taurus)
ERBB2 Activates PTK6 Signaling (Bos taurus)
ERBB2 promotes PTK6 autophosphorylation (Bos taurus)
ADP [cytosol]
PTK6 Down-Regulation (Bos taurus)
SRMS phosphorylates PTK6 (Bos taurus)
ADP [cytosol]
PTK6 Regulates Cell Cycle (Bos taurus)
PTK6 phosphorylates CDKN1B (Bos taurus)
ADP [cytosol]
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Bos taurus)
PTK6 phosphorylates ARHGAP35 (Bos taurus)
ADP [cytosol]
PTK6 phosphorylates BCAR1 (Bos taurus)
ADP [cytosol]
PTK6 phosphorylates PXN (Bos taurus)
ADP [cytosol]
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (Bos taurus)
PTK6 phosphorylates ARAP1 (Bos taurus)
ADP [cytosol]
PTK6 phosphorylates CBL (Bos taurus)
ADP [cytosol]
PTK6 promotes HIF1A stabilization (Bos taurus)
LINC01139 facilitates PTK6 autophosphorylation (Bos taurus)
ADP [cytosol]
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Extra-nuclear estrogen signaling (Bos taurus)
Estrogen-stimulated signaling through PRKCZ (Bos taurus)
PRKCZ autophosphorylates downstream of estrogen stimulation (Bos taurus)
ADP [cytosol]
PTK2 autophosphorylates downstream of EGFR (Bos taurus)
ADP [cytosol]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by EGFR (Bos taurus)
EGFR autophosphorylation (Bos taurus)
ADP [cytosol]
EGFR downregulation (Bos taurus)
Phosphorylation of CBL (EGFR:CBL) (Bos taurus)
ADP [cytosol]
Phosphorylation of CBL (EGFR:GRB2:CBL) (Bos taurus)
ADP [cytosol]
EGFR interacts with phospholipase C-gamma (Bos taurus)
EGFR activates PLC-gamma1 by phosphorylation (Bos taurus)
ADP [cytosol]
GAB1 signalosome (Bos taurus)
GAB1 phosphorylation by EGFR kinase (Bos taurus)
ADP [cytosol]
Phosphorylation of EGFR by SRC kinase (Bos taurus)
ADP [cytosol]
SHC1 events in EGFR signaling (Bos taurus)
SHC1 phosphorylation by phosphorylated EGFR (Bos taurus)
ADP [cytosol]
Signaling by ERBB2 (Bos taurus)
ERBB2 Activates PTK6 Signaling (Bos taurus)
ERBB2 promotes PTK6 autophosphorylation (Bos taurus)
ADP [cytosol]
PI3K events in ERBB2 signaling (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)
ADP [cytosol]
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Bos taurus)
ADP [cytosol]
SHC1 events in ERBB2 signaling (Bos taurus)
SHC1 phosphorylation by ERBB2 heterodimers (Bos taurus)
ADP [cytosol]
SRC family kinases phosphorylate ERBB2 (Bos taurus)
ADP [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Bos taurus)
ADP [cytosol]
Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Bos taurus)
ADP [cytosol]
Signaling by ERBB4 (Bos taurus)
PI3K events in ERBB4 signaling (Bos taurus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Bos taurus)
ADP [cytosol]
SHC1 events in ERBB4 signaling (Bos taurus)
Phosphorylation of SHC1 by ERBB4 homodimers (Bos taurus)
ADP [cytosol]
Trans-autophosphorylation of ERBB4 homodimers (Bos taurus)
ADP [cytosol]
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Downstream signaling of activated FGFR1 (Bos taurus)
FRS-mediated FGFR1 signaling (Bos taurus)
Activated FGFR1 phosphorylates FRS2 (Bos taurus)
ADP [cytosol]
Activated FGFR1 phosphorylates FRS3 (Bos taurus)
ADP [cytosol]
Activated FGFR1:p-FRS phosphorylates PPTN11 (Bos taurus)
ADP [cytosol]
PI-3K cascade:FGFR1 (Bos taurus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
Phospholipase C-mediated cascade: FGFR1 (Bos taurus)
Activated FGFR1 phosphorylates PLCG1 (Bos taurus)
ADP [cytosol]
SHC-mediated cascade:FGFR1 (Bos taurus)
Activated FGFR1 phosphorylates SHC1 (Bos taurus)
ADP [cytosol]
FGFR1 ligand binding and activation (Bos taurus)
FGFR1b ligand binding and activation (Bos taurus)
Autocatalytic phosphorylation of FGFR1b (Bos taurus)
ADP [cytosol]
FGFR1c and Klotho ligand binding and activation (Bos taurus)
Autocatalytic phosphorylation of Klotho-bound FGFR1c (Bos taurus)
ADP [cytosol]
FGFR1c ligand binding and activation (Bos taurus)
Autocatalytic phosphorylation of FGFR1c (Bos taurus)
ADP [cytosol]
Negative regulation of FGFR1 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
SRC phosphorylates SPRY2 on Y55 and Y227 (Bos taurus)
ADP [cytosol]
Signaling by FGFR2 (Bos taurus)
Downstream signaling of activated FGFR2 (Bos taurus)
FRS-mediated FGFR2 signaling (Bos taurus)
Activated FGFR2 phosphorylates FRS2 (Bos taurus)
ADP [cytosol]
Activated FGFR2 phosphorylates PPTN11 (Bos taurus)
ADP [cytosol]
PI-3K cascade:FGFR2 (Bos taurus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
Phospholipase C-mediated cascade; FGFR2 (Bos taurus)
Activated FGFR2 phosphorylates PLCG1 (Bos taurus)
ADP [cytosol]
SHC-mediated cascade:FGFR2 (Bos taurus)
Activated FGFR2 phosphorylates SHC1 (Bos taurus)
ADP [cytosol]
FGFR2 ligand binding and activation (Bos taurus)
FGFR2b ligand binding and activation (Bos taurus)
Autocatalytic phosphorylation of FGFR2b (Bos taurus)
ADP [cytosol]
FGFR2c ligand binding and activation (Bos taurus)
Autocatalytic phosphorylation of FGFR2c (Bos taurus)
ADP [cytosol]
Negative regulation of FGFR2 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
SRC phosphorylates SPRY2 on Y55 and Y227 (Bos taurus)
ADP [cytosol]
Signaling by FGFR3 (Bos taurus)
Downstream signaling of activated FGFR3 (Bos taurus)
FRS-mediated FGFR3 signaling (Bos taurus)
Activated FGFR3 phosphorylates FRS2 (Bos taurus)
ADP [cytosol]
Activated FGFR3 phosphorylates PPTN11 (Bos taurus)
ADP [cytosol]
PI-3K cascade:FGFR3 (Bos taurus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
Phospholipase C-mediated cascade; FGFR3 (Bos taurus)
Activated FGFR3 phosphorylates PLCG1 (Bos taurus)
ADP [cytosol]
SHC-mediated cascade:FGFR3 (Bos taurus)
Activated FGFR3 phosphorylates SHC1 (Bos taurus)
ADP [cytosol]
FGFR3 ligand binding and activation (Bos taurus)
FGFR3b ligand binding and activation (Bos taurus)
Autocatalytic phosphorylation of FGFR3b (Bos taurus)
ADP [cytosol]
FGFR3c ligand binding and activation (Bos taurus)
Autocatalytic phosphorylation of FGFR3c (Bos taurus)
ADP [cytosol]
Negative regulation of FGFR3 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
SRC phosphorylates SPRY2 on Y55 and Y227 (Bos taurus)
ADP [cytosol]
Signaling by FGFR4 (Bos taurus)
Downstream signaling of activated FGFR4 (Bos taurus)
FRS-mediated FGFR4 signaling (Bos taurus)
Activated FGFR4 phosphorylates FRS2 (Bos taurus)
ADP [cytosol]
Activated FGFR4 phosphorylates FRS3 (Bos taurus)
ADP [cytosol]
Activated FGFR4 phosphorylates PPTN11 (Bos taurus)
ADP [cytosol]
PI-3K cascade:FGFR4 (Bos taurus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
Phospholipase C-mediated cascade; FGFR4 (Bos taurus)
Activated FGFR4 phosphorylates PLCG1 (Bos taurus)
ADP [cytosol]
SHC-mediated cascade:FGFR4 (Bos taurus)
Activated FGFR4 phosphorylates SHC1 (Bos taurus)
ADP [cytosol]
FGFR4 ligand binding and activation (Bos taurus)
Autocatalytic phosphorylation of FGFR4 (Bos taurus)
ADP [cytosol]
betaKlotho-mediated ligand binding (Bos taurus)
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Bos taurus)
ADP [cytosol]
Negative regulation of FGFR4 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
SRC phosphorylates SPRY2 on Y55 and Y227 (Bos taurus)
ADP [cytosol]
Signaling by Insulin receptor (Bos taurus)
Insulin receptor signalling cascade (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
Activation of AKT2 (Bos taurus)
PDPK1 phosphorylates AKT2 (Bos taurus)
ADP [cytosol]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
Signaling by MST1 (Bos taurus)
MST1R autophosphorylates (Bos taurus)
ADP [cytosol]
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
PI3K/AKT activation (Bos taurus)
PI3K produces PIP3 and other phosphatidyl inositides (Bos taurus)
ADP [cytosol]
Signalling to ERKs (Bos taurus)
Prolonged ERK activation events (Bos taurus)
ARMS-mediated activation (Bos taurus)
ARMS is phosphorylated by active TrkA receptor (Bos taurus)
ADP [cytosol]
Frs2-mediated activation (Bos taurus)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Bos taurus)
ADP [cytosol]
BRAF autophosphorylates downstream of RAP1 and NGF (Bos taurus)
ADP [cytosol]
FRS2 is phosphorylated by active TrkA receptor (Bos taurus)
ADP [cytosol]
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Bos taurus)
ADP [cytosol]
Signalling to RAS (Bos taurus)
p38MAPK events (Bos taurus)
p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Bos taurus)
ADP [cytosol]
Signaling by NTRK3 (TRKC) (Bos taurus)
Activated NTRK3 signals through PI3K (Bos taurus)
Activated NTRK3 promotes SRC autophosphorylation (Bos taurus)
ADP [cytosol]
NTF3 activates NTRK3 signaling (Bos taurus)
NTRK3 dimers trans-autophosphorylate (Bos taurus)
ADP [cytosol]
Signaling by SCF-KIT (Bos taurus)
Phosphorylation of GAB2 by SFKs (Bos taurus)
ADP [cytosol]
Phosphorylation of JAK2 (Bos taurus)
ADP [cytosol]
Phosphorylation of SHP2 by SFKs (Bos taurus)
ADP [cytosol]
Phosphorylation of STATs (Bos taurus)
ADP [cytosol]
Regulation of KIT signaling (Bos taurus)
Phosphorylation of APS (Bos taurus)
ADP [cytosol]
Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)
ADP [cytosol]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Bos taurus)
IGF1R signaling cascade (Bos taurus)
IRS-related events triggered by IGF1R (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
Activation of AKT2 (Bos taurus)
PDPK1 phosphorylates AKT2 (Bos taurus)
ADP [cytosol]
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
AXL autophosphorylates on Y772 and Y814 (Bos taurus)
ADP [cytosol]
FYN autophosphorylates (Bos taurus)
ADP [cytosol]
PTK2 autophosphorylates (Bos taurus)
ADP [cytosol]
Phosphorylation of SRC-1 (Bos taurus)
ADP [cytosol]
SRC-1 phosphorylates p-Y397-PTK2 (Bos taurus)
ADP [cytosol]
Src kinases phosphorylate VAV (Bos taurus)
ADP [cytosol]
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
ADP [cytosol]
VEGFR2 mediated cell proliferation (Bos taurus)
PDK1 phosphorylates PKC (Bos taurus)
ADP [cytosol]
PKC autophosphorylates (Bos taurus)
ADP [cytosol]
p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Bos taurus)
ADP [cytosol]
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases Activate NADPH Oxidases (Bos taurus)
MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Bos taurus)
ADP [cytosol]
PKC phosphorylates NCF1 (Bos taurus)
ADP [cytosol]
RHO GTPases Activate WASPs and WAVEs (Bos taurus)
Branching and elongation of mother and daughter filaments (Bos taurus)
Mother filament:ARP2/3:actin:ADP [cytosol] (Bos taurus)
Actin:ADP [cytosol] (Bos taurus)
ADP [cytosol]
RHO GTPases activate PAKs (Bos taurus)
PAK1 phosphorylates LIMK1 (Bos taurus)
ADP [cytosol]
Rho GTPase cycle (Bos taurus)
RHOBTB GTPase Cycle (Bos taurus)
RHOBTB3 ATPase cycle (Bos taurus)
RHOBTB3 hydrolyzes ATP (Bos taurus)
RHOBTB3:ADP [trans-Golgi network membrane] (Bos taurus)
ADP [cytosol]
Signaling by TGFB family members (Bos taurus)
Signaling by Activin (Bos taurus)
ACVR2A/B (ActRIIA/B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Bos taurus)
ADP [cytosol]
Signaling by WNT (Bos taurus)
Beta-catenin independent WNT signaling (Bos taurus)
Ca2+ pathway (Bos taurus)
Autophosphorylation and activation of CAMK2 (Bos taurus)
ADP [cytosol]
Dissociation of CaM and CAMK2 autophosphorylation (Bos taurus)
ADP [cytosol]
Degradation of beta-catenin by the destruction complex (Bos taurus)
AXIN is phosphorylated in the destruction complex (Bos taurus)
ADP [cytosol]
Beta-catenin phosphorylation cascade (Bos taurus)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Bos taurus)
ADP [cytosol]
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Bos taurus)
ADP [cytosol]
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Bos taurus)
ADP [cytosol]
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Bos taurus)
ADP [cytosol]
Phosphorylation of APC component of the destruction complex (Bos taurus)
ADP [cytosol]
TCF dependent signaling in response to WNT (Bos taurus)
WNT mediated activation of DVL (Bos taurus)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Bos taurus)
ADP [cytosol]
WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Bos taurus)
ADP [cytosol]
Transport of small molecules (Bos taurus)
ABC-family proteins mediated transport (Bos taurus)
ABC transporters in lipid homeostasis (Bos taurus)
ABCA12 transports lipids from cytosol to extracellular region (Bos taurus)
ADP [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Bos taurus)
ADP [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Bos taurus)
ADP [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Bos taurus)
ADP [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Bos taurus)
ADP [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Bos taurus)
ADP [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Bos taurus)
ADP [cytosol]
Mitochondrial ABC transporters (Bos taurus)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Bos taurus)
ADP [cytosol]
The ABCC family mediates organic anion transport (Bos taurus)
ADP [cytosol]
Ion channel transport (Bos taurus)
Ion transport by P-type ATPases (Bos taurus)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Bos taurus)
ADP [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Bos taurus)
ADP [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Bos taurus)
ADP [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Bos taurus)
ADP [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Bos taurus)
ADP [cytosol]
ATP4A/12A:ATP4B exchanges K+ for H+ (Bos taurus)
ADP [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Bos taurus)
ADP [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Bos taurus)
ADP [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Bos taurus)
Plasma lipoprotein remodeling (Bos taurus)
HDL remodeling (Bos taurus)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Bos taurus)
ADP [cytosol]
SLC-mediated transmembrane transport (Bos taurus)
Transport of vitamins, nucleosides, and related molecules (Bos taurus)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Bos taurus)
ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Bos taurus)
ADP [cytosol]
SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Bos taurus)
ADP [cytosol]
Vesicle-mediated transport (Bos taurus)
Membrane Trafficking (Bos taurus)
Clathrin-mediated endocytosis (Bos taurus)
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Bos taurus)
ADP [cytosol]
ER to Golgi Anterograde Transport (Bos taurus)
COPI-mediated anterograde transport (Bos taurus)
GBF1 stimulates ARF nucleotide exchange (Bos taurus)
ADP [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Bos taurus)
Retrograde transport at the Trans-Golgi-Network (Bos taurus)
ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Bos taurus)
RHOBTB3:ADP [trans-Golgi network membrane] (Bos taurus)
ADP [cytosol]
Autophagy (Caenorhabditis elegans)
Macroautophagy (Caenorhabditis elegans)
AMPK (complex) phosphorylates ULK1 (complex) (Caenorhabditis elegans)
ADP [cytosol]
Active MTORC1 phosphorylates ULK1 (Caenorhabditis elegans)
ADP [cytosol]
Beclin-1 complex phosphorylates PtdIns (Caenorhabditis elegans)
ADP [cytosol]
Selective autophagy (Caenorhabditis elegans)
Mitophagy (Caenorhabditis elegans)
Receptor Mediated Mitophagy (Caenorhabditis elegans)
FUNDC1 is phosphorylated by CK2 (Caenorhabditis elegans)
ADP [cytosol]
FUNDC1 is phosphorylated by ULK1 at Ser17 (Caenorhabditis elegans)
ADP [cytosol]
Thr-180 of ULK1 is phosphorylated (Caenorhabditis elegans)
ADP [cytosol]
ULK1 phosphorylates AMBRA1:BECN1 complex (Caenorhabditis elegans)
ADP [cytosol]
ULK1 phosphorylates ATG13 and RB1CC1 (Caenorhabditis elegans)
ADP [cytosol]
ULK1 phosphorylates Beclin-1 (Caenorhabditis elegans)
ADP [cytosol]
p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Caenorhabditis elegans)
ADP [cytosol]
Cell Cycle (Caenorhabditis elegans)
Cell Cycle Checkpoints (Caenorhabditis elegans)
G2/M Checkpoints (Caenorhabditis elegans)
G2/M DNA replication checkpoint (Caenorhabditis elegans)
Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Caenorhabditis elegans)
ADP [cytosol]
Cell Cycle, Mitotic (Caenorhabditis elegans)
M Phase (Caenorhabditis elegans)
Mitotic Metaphase and Anaphase (Caenorhabditis elegans)
Mitotic Anaphase (Caenorhabditis elegans)
Nuclear Envelope (NE) Reassembly (Caenorhabditis elegans)
Sealing of the nuclear envelope (NE) by ESCRT-III (Caenorhabditis elegans)
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Caenorhabditis elegans)
ADP [cytosol]
Mitotic Prometaphase (Caenorhabditis elegans)
Condensation of Prometaphase Chromosomes (Caenorhabditis elegans)
CK2 phosphorylates condensin I subunits (Caenorhabditis elegans)
ADP [cytosol]
EML4 and NUDC in mitotic spindle formation (Caenorhabditis elegans)
PLK1 phosphorylates NUDC (Caenorhabditis elegans)
ADP [cytosol]
Resolution of Sister Chromatid Cohesion (Caenorhabditis elegans)
CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Caenorhabditis elegans)
ADP [cytosol]
Phosphorylation of cohesin by PLK1 at chromosomal arms (Caenorhabditis elegans)
ADP [cytosol]
Mitotic Prophase (Caenorhabditis elegans)
Golgi Cisternae Pericentriolar Stack Reorganization (Caenorhabditis elegans)
MAPK3-3 or MAPK1 phosphorylate GORASP2 (Caenorhabditis elegans)
ADP [cytosol]
PLK1 phosphorylates GORASP1 (Caenorhabditis elegans)
ADP [cytosol]
Nuclear Envelope Breakdown (Caenorhabditis elegans)
Nuclear Pore Complex (NPC) Disassembly (Caenorhabditis elegans)
CDK1 phosphorylates NUP98 (Caenorhabditis elegans)
ADP [cytosol]
Mitotic G1 phase and G1/S transition (Caenorhabditis elegans)
G1/S Transition (Caenorhabditis elegans)
Cyclin E associated events during G1/S transition (Caenorhabditis elegans)
AKT phosphorylates p21Cip1 and p27Kip1 (Caenorhabditis elegans)
ADP [cytosol]
SCF(Skp2)-mediated degradation of p27/p21 (Caenorhabditis elegans)
PTK6 phosphorylates CDKN1B (Caenorhabditis elegans)
ADP [cytosol]
Mitotic G2-G2/M phases (Caenorhabditis elegans)
G2/M Transition (Caenorhabditis elegans)
Cyclin A/B1/B2 associated events during G2/M transition (Caenorhabditis elegans)
Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Caenorhabditis elegans)
ADP [cytosol]
Phosphorylation of Cyclin B1 in the CRS domain (Caenorhabditis elegans)
ADP [cytosol]
Polo-like kinase mediated events (Caenorhabditis elegans)
Activation of Cdc25C (Caenorhabditis elegans)
ADP [cytosol]
Regulation of PLK1 Activity at G2/M Transition (Caenorhabditis elegans)
CDK1 phosphorylates BORA (Caenorhabditis elegans)
ADP [cytosol]
PLK1 phosphorylates BORA (Caenorhabditis elegans)
ADP [cytosol]
S Phase (Caenorhabditis elegans)
Cyclin A:Cdk2-associated events at S phase entry (Caenorhabditis elegans)
AKT phosphorylates p21Cip1 and p27Kip1 (Caenorhabditis elegans)
ADP [cytosol]
SCF(Skp2)-mediated degradation of p27/p21 (Caenorhabditis elegans)
PTK6 phosphorylates CDKN1B (Caenorhabditis elegans)
ADP [cytosol]
Cellular responses to external stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular Senescence (Caenorhabditis elegans)
Oxidative Stress Induced Senescence (Caenorhabditis elegans)
MAP3K5 phosphorylates MKK3 and MKK6 (Caenorhabditis elegans)
ADP [cytosol]
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ADP [cytosol]
Cellular response to heat stress (Caenorhabditis elegans)
Regulation of HSF1-mediated heat shock response (Caenorhabditis elegans)
Constitutive phosphorylation by pERK1/2 (Caenorhabditis elegans)
ADP [cytosol]
Constitutive phosphorylation by GSK3 (Caenorhabditis elegans)
ADP [cytosol]
MAPKAPK2 phosphorylates HSF1 (Caenorhabditis elegans)
ADP [cytosol]
HSP90 chaperone cycle for steroid hormone receptors (SHR) (Caenorhabditis elegans)
ATP binding to HSP90 triggers conformation change (Caenorhabditis elegans)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Caenorhabditis elegans)
HSP70:ADP [cytosol] (Caenorhabditis elegans)
ADP [cytosol]
HSP90:STIP1:HSP70:nascent protein [cytosol] (Caenorhabditis elegans)
HSP70:ADP:nascent protein [cytosol] (Caenorhabditis elegans)
HSP70:ADP [cytosol] (Caenorhabditis elegans)
ADP [cytosol]
ATP hydrolysis by HSP70 (Caenorhabditis elegans)
HSP40:HSP70:ADP:nascent protein [cytosol] (Caenorhabditis elegans)
ADP [cytosol]
FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Caenorhabditis elegans)
HSP90:ATP:FKBP4:STIP1:HSP70:nascent protein [cytosol] (Caenorhabditis elegans)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Caenorhabditis elegans)
HSP70:ADP [cytosol] (Caenorhabditis elegans)
ADP [cytosol]
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Caenorhabditis elegans)
HSP70:ADP [cytosol] (Caenorhabditis elegans)
ADP [cytosol]
FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Caenorhabditis elegans)
HSP90:ATP:FKBP5:STIP1:HSP70:nascent protein [cytosol] (Caenorhabditis elegans)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Caenorhabditis elegans)
HSP70:ADP [cytosol] (Caenorhabditis elegans)
ADP [cytosol]
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Caenorhabditis elegans)
HSP70:ADP [cytosol] (Caenorhabditis elegans)
ADP [cytosol]
STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Caenorhabditis elegans)
HSP40:HSP70:ADP:nascent protein [cytosol] (Caenorhabditis elegans)
ADP [cytosol]
HSP90:STIP1:HSP70:nascent protein [cytosol] (Caenorhabditis elegans)
HSP70:ADP:nascent protein [cytosol] (Caenorhabditis elegans)
HSP70:ADP [cytosol] (Caenorhabditis elegans)
ADP [cytosol]
p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Caenorhabditis elegans)
HSP90:ATP:FKBP4:STIP1:HSP70:nascent protein [cytosol] (Caenorhabditis elegans)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Caenorhabditis elegans)
HSP70:ADP [cytosol] (Caenorhabditis elegans)
ADP [cytosol]
p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Caenorhabditis elegans)
HSP90:ATP:FKBP5:STIP1:HSP70:nascent protein [cytosol] (Caenorhabditis elegans)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Caenorhabditis elegans)
HSP70:ADP [cytosol] (Caenorhabditis elegans)
ADP [cytosol]
Developmental Biology (Caenorhabditis elegans)
Nervous system development (Caenorhabditis elegans)
Axon guidance (Caenorhabditis elegans)
EPH-Ephrin signaling (Caenorhabditis elegans)
EPH receptors autophosphorylate (Caenorhabditis elegans)
ADP [cytosol]
EPH-ephrin mediated repulsion of cells (Caenorhabditis elegans)
SFKs phosphorylate VAV2,3 (Caenorhabditis elegans)
ADP [cytosol]
EPHB-mediated forward signaling (Caenorhabditis elegans)
EPHB phosphorylates TIAM1 (Caenorhabditis elegans)
ADP [cytosol]
PAK1 autophosphorylates (Caenorhabditis elegans)
ADP [cytosol]
p-EPHB phosphorylates SDC2 (Caenorhabditis elegans)
ADP [cytosol]
Ephrin signaling (Caenorhabditis elegans)
PAKs autophosphorylate (Caenorhabditis elegans)
ADP [cytosol]
PAKs phosphorylate MLC (Caenorhabditis elegans)
ADP [cytosol]
L1CAM interactions (Caenorhabditis elegans)
Recycling pathway of L1 (Caenorhabditis elegans)
Phosphorylation of L1 by ERK (Caenorhabditis elegans)
ADP [cytosol]
Signal transduction by L1 (Caenorhabditis elegans)
Interaction of PAK1 with Rac1-GTP (Caenorhabditis elegans)
ADP [cytosol]
MAP2K1 phosphorylates MAPK3 (Caenorhabditis elegans)
ADP [cytosol]
MAP2K2 phosphorylates MAPK1 (Caenorhabditis elegans)
ADP [cytosol]
Phosphorylation of L1 by CK-II (Caenorhabditis elegans)
ADP [cytosol]
Netrin-1 signaling (Caenorhabditis elegans)
DCC mediated attractive signaling (Caenorhabditis elegans)
Phosphorylation of DCC by Fyn (Caenorhabditis elegans)
ADP [cytosol]
DSCAM interactions (Caenorhabditis elegans)
Activation of JNK by DSCAM (Caenorhabditis elegans)
ADP [cytosol]
Activation of p38MAPK by DSCAM (Caenorhabditis elegans)
ADP [cytosol]
Phosphorylation and activation of Ezrin (Caenorhabditis elegans)
ADP [cytosol]
Semaphorin interactions (Caenorhabditis elegans)
Sema4D in semaphorin signaling (Caenorhabditis elegans)
Sema4D induced cell migration and growth-cone collapse (Caenorhabditis elegans)
SEMA4D interacts with Plexin-B1:ErbB2 (Caenorhabditis elegans)
ADP [cytosol]
Sema4D mediated inhibition of cell attachment and migration (Caenorhabditis elegans)
SEMA4D interacts with Plexin-B1:Met (Caenorhabditis elegans)
ADP [cytosol]
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
Transcriptional Regulation by TP53 (Caenorhabditis elegans)
Regulation of TP53 Activity (Caenorhabditis elegans)
Regulation of TP53 Expression and Degradation (Caenorhabditis elegans)
Regulation of TP53 Degradation (Caenorhabditis elegans)
PDPK1 phosphorylates SGK1 (Caenorhabditis elegans)
ADP [cytosol]
TORC2 complex phosphorylates SGK1 (Caenorhabditis elegans)
ADP [cytosol]
Hemostasis (Caenorhabditis elegans)
Cell surface interactions at the vascular wall (Caenorhabditis elegans)
PECAM1 interactions (Caenorhabditis elegans)
Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Caenorhabditis elegans)
ADP [cytosol]
Factors involved in megakaryocyte development and platelet production (Caenorhabditis elegans)
Kinesins (Caenorhabditis elegans)
Kinesins move along microtubules consuming ATP (Caenorhabditis elegans)
ADP [cytosol]
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
Effects of PIP2 hydrolysis (Caenorhabditis elegans)
DAG kinase produces phosphatidic acid from DAG (Caenorhabditis elegans)
ADP [cytosol]
GPVI-mediated activation cascade (Caenorhabditis elegans)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Caenorhabditis elegans)
ADP [cytosol]
Response to elevated platelet cytosolic Ca2+ (Caenorhabditis elegans)
Disinhibition of SNARE formation (Caenorhabditis elegans)
Phosphorylation of Platelet Sec-1 (Caenorhabditis elegans)
ADP [cytosol]
Phosphorylation of Syntaxin-4 (Caenorhabditis elegans)
ADP [cytosol]
Platelet degranulation (Caenorhabditis elegans)
ABCC4 accumulation of dense granule contents (Caenorhabditis elegans)
ADP [cytosol]
Signal amplification (Caenorhabditis elegans)
ADP signalling through P2Y purinoceptor 1 (Caenorhabditis elegans)
P2Y purinoceptor 1 activates MAP kinase p38 alpha (Caenorhabditis elegans)
ADP [cytosol]
Platelet homeostasis (Caenorhabditis elegans)
Platelet sensitization by LDL (Caenorhabditis elegans)
PECAM1 is phosphorylated (Caenorhabditis elegans)
ADP [cytosol]
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Class I MHC mediated antigen processing & presentation (Caenorhabditis elegans)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Caenorhabditis elegans)
Transport of Antigen peptide in to ER (Caenorhabditis elegans)
ADP [cytosol]
Costimulation by the CD28 family (Caenorhabditis elegans)
CD28 co-stimulation (Caenorhabditis elegans)
CD28 dependent PI3K/Akt signaling (Caenorhabditis elegans)
PDPK1 phosphorylates AKT at T308 (Caenorhabditis elegans)
ADP [cytosol]
TORC2 (mTOR) phosphorylates AKT at S473 (Caenorhabditis elegans)
ADP [cytosol]
Rap1 signalling (Caenorhabditis elegans)
PKA/PKG phosphorylate Rap1GAP2 (Caenorhabditis elegans)
ADP [cytosol]
TCR signaling (Caenorhabditis elegans)
Downstream TCR signaling (Caenorhabditis elegans)
Phosphorylation of PKC theta (Caenorhabditis elegans)
ADP [cytosol]
Cytokine Signaling in Immune system (Caenorhabditis elegans)
Signaling by Interleukins (Caenorhabditis elegans)
Interleukin-1 family signaling (Caenorhabditis elegans)
Interleukin-1 signaling (Caenorhabditis elegans)
hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Caenorhabditis elegans)
ADP [cytosol]
Interleukin-37 signaling (Caenorhabditis elegans)
STAT3 phosphorylation (Caenorhabditis elegans)
ADP [cytosol]
Interleukin-38 signaling (Caenorhabditis elegans)
MAPK8 phosphorylation (Caenorhabditis elegans)
ADP [cytosol]
Interleukin-17 signaling (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ADP [cytosol]
Innate Immune System (Caenorhabditis elegans)
C-type lectin receptors (CLRs) (Caenorhabditis elegans)
CD209 (DC-SIGN) signaling (Caenorhabditis elegans)
PAK phosphorylates p21 RAF1 on S338 (Caenorhabditis elegans)
ADP [cytosol]
SFKs phosphorylates RAF1 on Y340,Y341 (Caenorhabditis elegans)
ADP [cytosol]
Dectin-2 family (Caenorhabditis elegans)
SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Caenorhabditis elegans)
ADP [cytosol]
Cytosolic sensors of pathogen-associated DNA (Caenorhabditis elegans)
STING mediated induction of host immune responses (Caenorhabditis elegans)
STAT6-mediated induction of chemokines (Caenorhabditis elegans)
p-S407-STAT6 is phosphorylated at Tyr641 (Caenorhabditis elegans)
ADP [cytosol]
Fc epsilon receptor (FCERI) signaling (Caenorhabditis elegans)
Autophosphorylation of LYN kinase (Caenorhabditis elegans)
ADP [cytosol]
FCERI mediated MAPK activation (Caenorhabditis elegans)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ADP [cytosol]
FCERI mediated NF-kB activation (Caenorhabditis elegans)
Autophosphorylation of PKC-theta (Caenorhabditis elegans)
ADP [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Caenorhabditis elegans)
Regulation of actin dynamics for phagocytic cup formation (Caenorhabditis elegans)
ABL phosphorylates WAVEs (Caenorhabditis elegans)
ADP [cytosol]
Autophosphorylation of PAK1 (Caenorhabditis elegans)
ADP [cytosol]
Detachment of WASP/WAVE (Caenorhabditis elegans)
Mother filament:ARP2/3:actin:ADP [cytosol] (Caenorhabditis elegans)
Actin:ADP [cytosol] (Caenorhabditis elegans)
ADP [cytosol]
p-ERK phosphorylates WAVEs and ABI (Caenorhabditis elegans)
ADP [cytosol]
Role of phospholipids in phagocytosis (Caenorhabditis elegans)
DAG stimulates protein kinase C-delta (Caenorhabditis elegans)
ADP [cytosol]
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Caenorhabditis elegans)
NOD1/2 Signaling Pathway (Caenorhabditis elegans)
Activation of p38 MAPK (Caenorhabditis elegans)
ADP [cytosol]
Toll-like Receptor Cascades (Caenorhabditis elegans)
Toll Like Receptor 10 (TLR10) Cascade (Caenorhabditis elegans)
MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ADP [cytosol]
Toll Like Receptor 2 (TLR2) Cascade (Caenorhabditis elegans)
Toll Like Receptor TLR1:TLR2 Cascade (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ADP [cytosol]
Toll Like Receptor TLR6:TLR2 Cascade (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ADP [cytosol]
Toll Like Receptor 3 (TLR3) Cascade (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ADP [cytosol]
Toll Like Receptor 4 (TLR4) Cascade (Caenorhabditis elegans)
MyD88-independent TLR4 cascade (Caenorhabditis elegans)
TRIF(TICAM1)-mediated TLR4 signaling (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ADP [cytosol]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ADP [cytosol]
Toll Like Receptor 5 (TLR5) Cascade (Caenorhabditis elegans)
MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ADP [cytosol]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Caenorhabditis elegans)
MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ADP [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Caenorhabditis elegans)
MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Caenorhabditis elegans)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)
ADP [cytosol]
Metabolism (Caenorhabditis elegans)
Biological oxidations (Caenorhabditis elegans)
Phase II - Conjugation of compounds (Caenorhabditis elegans)
Cytosolic sulfonation of small molecules (Caenorhabditis elegans)
Transport and synthesis of PAPS (Caenorhabditis elegans)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Caenorhabditis elegans)
ADP [cytosol]
Glutathione conjugation (Caenorhabditis elegans)
Glutathione synthesis and recycling (Caenorhabditis elegans)
GCL ligates L-Glu to L-Cys (Caenorhabditis elegans)
ADP [cytosol]
GSS:Mg2+ dimer synthesizes GSH (Caenorhabditis elegans)
ADP [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Caenorhabditis elegans)
ADP [cytosol]
Inositol phosphate metabolism (Caenorhabditis elegans)
Synthesis of IP3 and IP4 in the cytosol (Caenorhabditis elegans)
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Caenorhabditis elegans)
ADP [cytosol]
Synthesis of pyrophosphates in the cytosol (Caenorhabditis elegans)
1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Caenorhabditis elegans)
ADP [cytosol]
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Caenorhabditis elegans)
ADP [cytosol]
5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Caenorhabditis elegans)
ADP [cytosol]
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Caenorhabditis elegans)
ADP [cytosol]
I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Caenorhabditis elegans)
ADP [cytosol]
I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Caenorhabditis elegans)
ADP [cytosol]
IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Caenorhabditis elegans)
ADP [cytosol]
IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Caenorhabditis elegans)
ADP [cytosol]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Glutamate and glutamine metabolism (Caenorhabditis elegans)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Caenorhabditis elegans)
ADP [cytosol]
Metabolism of carbohydrates (Caenorhabditis elegans)
Formation of xylulose-5-phosphate (Caenorhabditis elegans)
XYLB phosphorylates D-xylulose (Caenorhabditis elegans)
ADP [cytosol]
Fructose metabolism (Caenorhabditis elegans)
Fructose catabolism (Caenorhabditis elegans)
DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)
ADP [cytosol]
GLYCTK phosphorylates DGA to 3PDGA (Caenorhabditis elegans)
ADP [cytosol]
Glucose metabolism (Caenorhabditis elegans)
Gluconeogenesis (Caenorhabditis elegans)
ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate (Caenorhabditis elegans)
ADP [cytosol]
Glycolysis (Caenorhabditis elegans)
1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Caenorhabditis elegans)
ADP [cytosol]
ADPGK:Mg2+ phosphorylates Glc to G6P (Caenorhabditis elegans)
ADP [cytosol]
D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Caenorhabditis elegans)
ADP [cytosol]
HK1,2,3,GCK phosphorylate Glc to form G6P (Caenorhabditis elegans)
ADP [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Caenorhabditis elegans)
D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Caenorhabditis elegans)
ADP [cytosol]
phosphoenolpyruvate + ADP => pyruvate + ATP (Caenorhabditis elegans)
ADP [cytosol]
Glycogen metabolism (Caenorhabditis elegans)
Glycogen breakdown (glycogenolysis) (Caenorhabditis elegans)
glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Caenorhabditis elegans)
ADP [cytosol]
Glycosaminoglycan metabolism (Caenorhabditis elegans)
Transport and synthesis of PAPS (Caenorhabditis elegans)
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Caenorhabditis elegans)
ADP [cytosol]
Pentose phosphate pathway (Caenorhabditis elegans)
RBKS phosphorylates ribose to R5P (Caenorhabditis elegans)
ADP [cytosol]
SHPK phosphorylates Sedo to Sedo7P (Caenorhabditis elegans)
ADP [cytosol]
Metabolism of lipids (Caenorhabditis elegans)
Fatty acid metabolism (Caenorhabditis elegans)
Carnitine metabolism (Caenorhabditis elegans)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Caenorhabditis elegans)
ADP [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Caenorhabditis elegans)
ADP [cytosol]
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Caenorhabditis elegans)
ADP [cytosol]
Fatty acyl-CoA biosynthesis (Caenorhabditis elegans)
ACLY tetramer transforms CIT to Ac-CoA (Caenorhabditis elegans)
ADP [cytosol]
acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Caenorhabditis elegans)
ADP [cytosol]
Metabolism of steroids (Caenorhabditis elegans)
Cholesterol biosynthesis (Caenorhabditis elegans)
MVD decarboxylates MVA5PP to IPPP (Caenorhabditis elegans)
ADP [cytosol]
Mevalonate is phosphorylated to mevalonate-5-phosphate (Caenorhabditis elegans)
ADP [cytosol]
Mevalonate-5-phosphate is further phosphorylated. (Caenorhabditis elegans)
ADP [cytosol]
Phospholipid metabolism (Caenorhabditis elegans)
Glycerophospholipid biosynthesis (Caenorhabditis elegans)
Synthesis of PC (Caenorhabditis elegans)
Casein kinase II phosphorylates STARD10 (Caenorhabditis elegans)
ADP [cytosol]
Cho is phosphorylated to PCho by CHK dimer (Caenorhabditis elegans)
ADP [cytosol]
Synthesis of PE (Caenorhabditis elegans)
ETA is phosphorylated to PETA by CHK/ETNK (Caenorhabditis elegans)
ADP [cytosol]
PI Metabolism (Caenorhabditis elegans)
Synthesis of PIPs at the ER membrane (Caenorhabditis elegans)
PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Caenorhabditis elegans)
ADP [cytosol]
Synthesis of PIPs at the Golgi membrane (Caenorhabditis elegans)
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Caenorhabditis elegans)
ADP [cytosol]
PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Caenorhabditis elegans)
ADP [cytosol]
PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Caenorhabditis elegans)
ADP [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Caenorhabditis elegans)
ADP [cytosol]
Synthesis of PIPs at the early endosome membrane (Caenorhabditis elegans)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Caenorhabditis elegans)
ADP [cytosol]
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Caenorhabditis elegans)
ADP [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Caenorhabditis elegans)
ADP [cytosol]
Synthesis of PIPs at the late endosome membrane (Caenorhabditis elegans)
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Caenorhabditis elegans)
ADP [cytosol]
Synthesis of PIPs at the plasma membrane (Caenorhabditis elegans)
PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Caenorhabditis elegans)
ADP [cytosol]
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Caenorhabditis elegans)
ADP [cytosol]
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
ADP [cytosol]
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Caenorhabditis elegans)
ADP [cytosol]
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Caenorhabditis elegans)
ADP [cytosol]
PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Caenorhabditis elegans)
ADP [cytosol]
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Caenorhabditis elegans)
ADP [cytosol]
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)
ADP [cytosol]
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Caenorhabditis elegans)
ADP [cytosol]
Sphingolipid metabolism (Caenorhabditis elegans)
Glycosphingolipid metabolism (Caenorhabditis elegans)
CERK phosphorylates CERA to form C1P (Caenorhabditis elegans)
ADP [cytosol]
Sphingolipid de novo biosynthesis (Caenorhabditis elegans)
PRKD1,2,3 phosphorylates COL4A3BP-2 (Caenorhabditis elegans)
ADP [cytosol]
SPHK1 phosphorylates SPG to S1P (Caenorhabditis elegans)
ADP [cytosol]
SPHK2 phosphorylates SPG to S1P (Caenorhabditis elegans)
ADP [cytosol]
monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP (Caenorhabditis elegans)
ADP [cytosol]
sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Caenorhabditis elegans)
ADP [cytosol]
Triglyceride metabolism (Caenorhabditis elegans)
Triglyceride biosynthesis (Caenorhabditis elegans)
Conversion of Glycerol to Glycerol-3-phosphate (Caenorhabditis elegans)
ADP [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Caenorhabditis elegans)
eNOS activation (Caenorhabditis elegans)
AKT1 phosphorylates eNOS (Caenorhabditis elegans)
ADP [cytosol]
Metabolism of nucleotides (Caenorhabditis elegans)
Interconversion of nucleotide di- and triphosphates (Caenorhabditis elegans)
(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Caenorhabditis elegans)
(d)ADP [cytosol]
ADP [cytosol]
ADP [cytosol]
(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Caenorhabditis elegans)
(d)NDPs [cytosol]
ADP [cytosol]
ADP [cytosol]
(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Caenorhabditis elegans)
(d)ADP [cytosol]
ADP [cytosol]
ADP [cytosol]
(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Caenorhabditis elegans)
ADP [cytosol]
(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Caenorhabditis elegans)
ADP [cytosol]
![ADP [cytosol] icon](/icon/R-ICO-012397.svg){kind=icon}