Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Pi [cytosol]
Stable Identifier
R-ALL-29372
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
Orthophosphate, hydrogenphosphate, Phosphate, Inorganic Phosphate
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Mycobacterium tuberculosis
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Autophagy (Bos taurus)
Macroautophagy (Bos taurus)
ULK1 is dephosphorylated (Bos taurus)
Pi [cytosol]
Cell Cycle (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
M Phase (Bos taurus)
Mitotic Metaphase and Anaphase (Bos taurus)
Mitotic Anaphase (Bos taurus)
Nuclear Envelope (NE) Reassembly (Bos taurus)
Initiation of Nuclear Envelope (NE) Reformation (Bos taurus)
PP2A dephosphorylates BANF1 (Bos taurus)
Pi [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Bos taurus)
RAN stimulates fusion of nuclear envelope (NE) membranes (Bos taurus)
Pi [cytosol]
Sealing of the nuclear envelope (NE) by ESCRT-III (Bos taurus)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Bos taurus)
Pi [cytosol]
Mitotic Prometaphase (Bos taurus)
Condensation of Prometaphase Chromosomes (Bos taurus)
Dephosphorylation of CK2-modified condensin I (Bos taurus)
Pi [cytosol]
Resolution of Sister Chromatid Cohesion (Bos taurus)
PP2A-B56 dephosphorylates centromeric cohesin (Bos taurus)
Pi [cytosol]
PPP1CC dephosphorylates PLK1 (Bos taurus)
Pi [cytosol]
Mitotic G2-G2/M phases (Bos taurus)
G2/M Transition (Bos taurus)
Cyclin A/B1/B2 associated events during G2/M transition (Bos taurus)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Bos taurus)
Pi [cytosol]
Cellular responses to stimuli (Bos taurus)
Cellular responses to mechanical stimuli (Bos taurus)
Response of endothelial cells to shear stress (Bos taurus)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Bos taurus)
PP2A dephosphorylates serine-127 of YAP1 (Bos taurus)
Pi [cytosol]
PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) (Bos taurus)
Pi [cytosol]
Cellular responses to stress (Bos taurus)
Cellular response to heat stress (Bos taurus)
Regulation of HSF1-mediated heat shock response (Bos taurus)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Bos taurus)
Pi [cytosol]
Cellular response to starvation (Bos taurus)
Amino acids regulate mTORC1 (Bos taurus)
RRAGA,B hydrolyzes GTP (Bos taurus)
Pi [cytosol]
RRAGC,D hydrolyzes GTP (Bos taurus)
Pi [cytosol]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Bos taurus)
ATP hydrolysis by HSP70 (Bos taurus)
Pi [cytosol]
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
EPH-Ephrin signaling (Bos taurus)
EPHB-mediated forward signaling (Bos taurus)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Bos taurus)
Pi [cytosol]
L1CAM interactions (Bos taurus)
Recycling pathway of L1 (Bos taurus)
Formation of clathrin coated vesicle (Bos taurus)
Pi [cytosol]
Semaphorin interactions (Bos taurus)
Sema4D in semaphorin signaling (Bos taurus)
Sema4D mediated inhibition of cell attachment and migration (Bos taurus)
Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Bos taurus)
Pi [cytosol]
Inactivation of Rho-GTP by p190RhoGAP (Bos taurus)
Pi [cytosol]
Signaling by ROBO receptors (Bos taurus)
SLIT2:ROBO1 increases RHOA activity (Bos taurus)
MYO9B inactivates RHOA (Bos taurus)
Pi [cytosol]
Drug ADME (Bos taurus)
Aspirin ADME (Bos taurus)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Bos taurus)
Pi [cytosol]
Azathioprine ADME (Bos taurus)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
Paracetamol ADME (Bos taurus)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Bos taurus)
Pi [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Bos taurus)
Pi [cytosol]
Prednisone ADME (Bos taurus)
ABCB1 transports PREDN,PREDL out of hepatic cells (Bos taurus)
Pi [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Bos taurus)
Pi [cytosol]
ABCB1 transports xenobiotics out of the cell (Bos taurus)
Pi [cytosol]
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional Regulation by TP53 (Bos taurus)
TP53 Regulates Metabolic Genes (Bos taurus)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Bos taurus)
Pi [cytosol]
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Bos taurus)
Pi [cytosol]
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
Platelet Aggregation (Plug Formation) (Bos taurus)
Integrin signaling (Bos taurus)
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
Pi [cytosol]
Response to elevated platelet cytosolic Ca2+ (Bos taurus)
Platelet degranulation (Bos taurus)
ABCC4 accumulation of dense granule contents (Bos taurus)
Pi [cytosol]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Bos taurus)
Transport of Antigen peptide in to ER (Bos taurus)
Pi [cytosol]
MHC class II antigen presentation (Bos taurus)
Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Bos taurus)
Pi [cytosol]
Internalization of MHC II:Ii clathrin coated vesicle (Bos taurus)
Pi [cytosol]
Translocation of TGN-lysosome vesicle to lysosome (Bos taurus)
Pi [cytosol]
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
Hydrolysis of PIP3 to PI(3,4)P2 (Bos taurus)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Bos taurus)
Pi [cytosol]
Phosphorylation of CD3 and TCR zeta chains (Bos taurus)
Dephosphorylation of Lck-pY505 by CD45 (Bos taurus)
Pi [cytosol]
Inactivation of LCK by PTPN22 (Bos taurus)
Pi [cytosol]
Translocation of ZAP-70 to Immunological synapse (Bos taurus)
PTPN22 dephosphorylates ZAP70 (Bos taurus)
Pi [cytosol]
Cytokine Signaling in Immune system (Bos taurus)
FLT3 Signaling (Bos taurus)
Negative regulation of FLT3 (Bos taurus)
PTPRJ dephosphorylates active FLT3 (Bos taurus)
Pi [cytosol]
Growth hormone receptor signaling (Bos taurus)
PTP1B dephosphorylates GHR (Bos taurus)
Pi [cytosol]
Interferon Signaling (Bos taurus)
Interferon alpha/beta signaling (Bos taurus)
Regulation of IFNA/IFNB signaling (Bos taurus)
Dephosphorylation of JAK1 by SHP1 (Bos taurus)
Pi [cytosol]
Dephosphorylation of STAT1 by SHP2 (Bos taurus)
Pi [cytosol]
Dephosphorylation of TYK2 by PTP1B (Bos taurus)
Pi [cytosol]
Signaling by CSF3 (G-CSF) (Bos taurus)
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Bos taurus)
Pi [cytosol]
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
CLEC7A (Dectin-1) induces NFAT activation (Bos taurus)
Calcineurin binds and dephosphorylates NFAT (Bos taurus)
Pi [cytosol]
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated Ca+2 mobilization (Bos taurus)
Calcineurin binds and dephosphorylates NFAT (Bos taurus)
Pi [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
Extension of pseudopodia by myosin-X in a PI3K dependent manner (Bos taurus)
Pi [cytosol]
Role of myosins in phagosome formation (Bos taurus)
Pi [cytosol]
Role of phospholipids in phagocytosis (Bos taurus)
Conversion of PA into DAG by PAP-1 (Bos taurus)
Pi [cytosol]
Metabolism (Bos taurus)
Aerobic respiration and respiratory electron transport (Bos taurus)
Pyruvate metabolism (Bos taurus)
Regulation of pyruvate metabolism (Bos taurus)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Bos taurus)
Pi [cytosol]
Biological oxidations (Bos taurus)
Phase II - Conjugation of compounds (Bos taurus)
Cytosolic sulfonation of small molecules (Bos taurus)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Bos taurus)
Pi [cytosol]
Glutathione conjugation (Bos taurus)
Glutathione synthesis and recycling (Bos taurus)
GCL ligates L-Glu to L-Cys (Bos taurus)
Pi [cytosol]
GSS:Mg2+ dimer synthesizes GSH (Bos taurus)
Pi [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Bos taurus)
Pi [cytosol]
Methylation (Bos taurus)
MAT1A multimers transfer Ado from ATP to L-Met (Bos taurus)
Pi [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Bos taurus)
Pi [cytosol]
Inositol phosphate metabolism (Bos taurus)
Synthesis of IP2, IP, and Ins in the cytosol (Bos taurus)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Bos taurus)
Pi [cytosol]
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Bos taurus)
Pi [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Bos taurus)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Bos taurus)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Bos taurus)
Pi [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Bos taurus)
Pi [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)
Pi [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)
Pi [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)
Pi [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Bos taurus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Bos taurus)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Bos taurus)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Bos taurus)
Pi [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Bos taurus)
Pi [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Bos taurus)
Pi [cytosol]
Synthesis of pyrophosphates in the cytosol (Bos taurus)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Bos taurus)
Pi [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Bos taurus)
Pi [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)
Pi [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)
Pi [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Bos taurus)
Pi [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Bos taurus)
Pi [cytosol]
Metabolism of amino acids and derivatives (Bos taurus)
Glutamate and glutamine metabolism (Bos taurus)
N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Bos taurus)
Pi [cytosol]
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Bos taurus)
Pi [cytosol]
Histidine catabolism (Bos taurus)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Bos taurus)
Pi [cytosol]
Selenoamino acid metabolism (Bos taurus)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Bos taurus)
SeMet is converted to AdoSeMet by MAT (Bos taurus)
Pi [cytosol]
Serine metabolism (Bos taurus)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Bos taurus)
Pi [cytosol]
Sulfur amino acid metabolism (Bos taurus)
MAT1A multimers transfer Ado from ATP to L-Met (Bos taurus)
Pi [cytosol]
Methionine salvage pathway (Bos taurus)
Acireductone is created (Bos taurus)
Pi [cytosol]
MTA is cleaved and phosphorylated (Bos taurus)
Pi [cytosol]
Metabolism of carbohydrates and carbohydrate derivatives (Bos taurus)
Glucose metabolism (Bos taurus)
Gluconeogenesis (Bos taurus)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Bos taurus)
Pi [cytosol]
GAPDH tetramers reduce 1,3BPG to GA3P (Bos taurus)
Pi [cytosol]
SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Bos taurus)
Pi [cytosol]
SLC7A4 exchanges G6P for Pi across the ER membrane (Bos taurus)
Pi [cytosol]
Glycolysis (Bos taurus)
GADPH tetramer dehydrogenates GA3P (Bos taurus)
Pi [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Bos taurus)
PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (Bos taurus)
Pi [cytosol]
Glycogen metabolism (Bos taurus)
Glycogen breakdown (glycogenolysis) (Bos taurus)
glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Bos taurus)
Pi [cytosol]
poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Bos taurus)
Pi [cytosol]
Glycogen synthesis (Bos taurus)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Bos taurus)
Pi [cytosol]
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Bos taurus)
Pi [cytosol]
Pentose phosphate pathway (Bos taurus)
5-Phosphoribose 1-diphosphate biosynthesis (Bos taurus)
PRPS dimers pyrophosphorylate R5P using ATP (Bos taurus)
Pi [cytosol]
PRPS1 dimer pyrophosphorylates R5P using dATP (Bos taurus)
Pi [cytosol]
Metabolism of lipids (Bos taurus)
Fatty acid metabolism (Bos taurus)
Arachidonate metabolism (Bos taurus)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Bos taurus)
LTC4 is exported from the cytosol by ABCC1 (Bos taurus)
Pi [cytosol]
Carnitine shuttle (Bos taurus)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Bos taurus)
Pi [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Bos taurus)
Pi [cytosol]
Fatty acyl-CoA biosynthesis (Bos taurus)
ACLY tetramer transforms CIT to Ac-CoA (Bos taurus)
Pi [cytosol]
Formation of Malonyl-CoA from Acetyl-CoA (liver) (Bos taurus)
Pi [cytosol]
Metabolism of steroids (Bos taurus)
Bile acid and bile salt metabolism (Bos taurus)
Recycling of bile acids and salts (Bos taurus)
ABCB11 transports bile salts from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
ABCC3 transports bile salts from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
Synthesis of bile acids and bile salts (Bos taurus)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Bos taurus)
ABCB11 transports bile salts from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
Cholesterol biosynthesis (Bos taurus)
MVD decarboxylates MVA5PP to IPPP (Bos taurus)
Pi [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Bos taurus)
Pi [cytosol]
Phospholipid metabolism (Bos taurus)
Glycerophospholipid biosynthesis (Bos taurus)
PGP:Mg2+ dimer hydrolyses G3P to glycerol (Bos taurus)
Pi [cytosol]
Synthesis of PC (Bos taurus)
PA is dephosphorylated to DAG by LPIN (Bos taurus)
Pi [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Bos taurus)
Pi [cytosol]
Synthesis of PE (Bos taurus)
PA is dephosphorylated to DAG by LPIN (Bos taurus)
Pi [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Bos taurus)
Pi [cytosol]
PI Metabolism (Bos taurus)
Synthesis of PIPs at the ER membrane (Bos taurus)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Bos taurus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Bos taurus)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Bos taurus)
Pi [cytosol]
Synthesis of PIPs at the Golgi membrane (Bos taurus)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Bos taurus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Bos taurus)
Pi [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Bos taurus)
Pi [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Bos taurus)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Bos taurus)
Pi [cytosol]
Synthesis of PIPs at the early endosome membrane (Bos taurus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Bos taurus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Bos taurus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Bos taurus)
Pi [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Bos taurus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Bos taurus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Bos taurus)
Pi [cytosol]
Synthesis of PIPs at the late endosome membrane (Bos taurus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Bos taurus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Bos taurus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Bos taurus)
Pi [cytosol]
Synthesis of PIPs at the plasma membrane (Bos taurus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Bos taurus)
Pi [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Bos taurus)
Pi [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Bos taurus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Bos taurus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Bos taurus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Bos taurus)
Pi [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Bos taurus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Bos taurus)
Pi [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Bos taurus)
Pi [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Bos taurus)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Bos taurus)
Pi [cytosol]
Sphingolipid metabolism (Bos taurus)
Sphingolipid catabolism (Bos taurus)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Bos taurus)
Pi [cytosol]
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Bos taurus)
Pi [cytosol]
Sphingolipid de novo biosynthesis (Bos taurus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Bos taurus)
Pi [cytosol]
PPM1L dephosphorylates multiphospho-CERT1-2 (Bos taurus)
Pi [cytosol]
Triglyceride metabolism (Bos taurus)
Triglyceride biosynthesis (Bos taurus)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Bos taurus)
Pi [cytosol]
Metabolism of nucleotides (Bos taurus)
Interconversion of nucleotide di- and triphosphates (Bos taurus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Bos taurus)
Pi [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Bos taurus)
Pi [cytosol]
Nucleotide biosynthesis (Bos taurus)
Purine ribonucleoside monophosphate biosynthesis (Bos taurus)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Bos taurus)
Pi [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Bos taurus)
Pi [cytosol]
FGAM + ATP => AIR + ADP + Pi (Bos taurus)
Pi [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Bos taurus)
Pi [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Bos taurus)
Pi [cytosol]
Pyrimidine biosynthesis (Bos taurus)
CAD hexamer transforms CAP to N-carb-L-Asp (Bos taurus)
Pi [cytosol]
CAD hexamer transforms L-Gln to CAP (Bos taurus)
Pi [cytosol]
Nucleotide catabolism (Bos taurus)
Purine catabolism (Bos taurus)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Bos taurus)
Pi [cytosol]
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Bos taurus)
Pi [cytosol]
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Bos taurus)
Pi [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Bos taurus)
Pi [cytosol]
PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Bos taurus)
Pi [cytosol]
PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Bos taurus)
Pi [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Bos taurus)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Bos taurus)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Bos taurus)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)
Pi [cytosol]
Pyrimidine catabolism (Bos taurus)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Bos taurus)
Pi [cytosol]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Bos taurus)
Pi [cytosol]
(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Bos taurus)
Pi [cytosol]
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Bos taurus)
Pi [cytosol]
Nucleotide salvage (Bos taurus)
Purine salvage (Bos taurus)
PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Bos taurus)
Pi [cytosol]
PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Bos taurus)
Pi [cytosol]
Pyrimidine salvage (Bos taurus)
HDHD1:Mg2+ dephosphorylates PURIDP (Bos taurus)
Pi [cytosol]
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Bos taurus)
Pi [cytosol]
Metabolism of porphyrins (Bos taurus)
Heme biosynthesis (Bos taurus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
Heme degradation (Bos taurus)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Bos taurus)
Transport of RCbl within the body (Bos taurus)
ABCC1 transports cytosolic RCbl to extracellular region (Bos taurus)
Pi [cytosol]
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Bos taurus)
Pi [cytosol]
Uptake of dietary cobalamins into enterocytes (Bos taurus)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Bos taurus)
Pi [cytosol]
Metabolism of folate and pterines (Bos taurus)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Bos taurus)
Pi [cytosol]
FPGS-2 transforms THF to THFPG (Bos taurus)
Pi [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Bos taurus)
Pi [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)
Pi [cytosol]
Nicotinate metabolism (Bos taurus)
Nicotinamide salvage (Bos taurus)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Bos taurus)
Pi [cytosol]
Vitamin B1 (thiamin) metabolism (Bos taurus)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Bos taurus)
Pi [cytosol]
Vitamin B2 (riboflavin) metabolism (Bos taurus)
2xTRAP hydrolyzes FMN to RIB (Bos taurus)
Pi [cytosol]
Vitamin B5 (pantothenate) metabolism (Bos taurus)
PANK4 hydrolyzes PPANT to pantetheine (Bos taurus)
Pi [cytosol]
Pyrophosphate hydrolysis (Bos taurus)
LHPP:Mg2+ dimer hydrolyses PPi (Bos taurus)
Pi [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Bos taurus)
Pi [cytosol]
Metabolism of RNA (Bos taurus)
Deadenylation-dependent mRNA decay (Bos taurus)
mRNA decay by 3' to 5' exoribonuclease (Bos taurus)
NT5C3B hydrolyses 7MGP to 7MG (Bos taurus)
Pi [cytosol]
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Asparagine N-linked glycosylation (Bos taurus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Bos taurus)
Synthesis of substrates in N-glycan biosythesis (Bos taurus)
Sialic acid metabolism (Bos taurus)
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Bos taurus)
Pi [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Bos taurus)
Pi [cytosol]
Synthesis of dolichyl-phosphate (Bos taurus)
DOLPP1 dephosphorylates DOLDP to DOLP (Bos taurus)
Pi [cytosol]
MVD decarboxylates MVA5PP to IPPP (Bos taurus)
Pi [cytosol]
Transport to the Golgi and subsequent modification (Bos taurus)
ER to Golgi Anterograde Transport (Bos taurus)
COPI-mediated anterograde transport (Bos taurus)
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Bos taurus)
Pi [cytosol]
COPII-mediated vesicle transport (Bos taurus)
Loss of SAR1B GTPase (Bos taurus)
Pi [cytosol]
NSF ATPase activity dissociates cis-SNARE (Bos taurus)
Pi [cytosol]
PP6 dephosphorylates SEC24 (Bos taurus)
Pi [cytosol]
Vesicle budding (Bos taurus)
Pi [cytosol]
Carboxyterminal post-translational modifications of tubulin (Bos taurus)
TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Bos taurus)
Pi [cytosol]
TTLLs polyglutamylate tubulin (Bos taurus)
Pi [cytosol]
Protein folding (Bos taurus)
Chaperonin-mediated protein folding (Bos taurus)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Bos taurus)
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Bos taurus)
Pi [cytosol]
Surfactant metabolism (Bos taurus)
ABCA3 transports PC, PG from ER membrane to lamellar body (Bos taurus)
Pi [cytosol]
SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Bos taurus)
Pi [cytosol]
Translation (Bos taurus)
Eukaryotic Translation Initiation (Bos taurus)
Cap-dependent Translation Initiation (Bos taurus)
GTP hydrolysis and joining of the 60S ribosomal subunit (Bos taurus)
eIF5B:GTP is hydrolyzed and released (Bos taurus)
Pi [cytosol]
Ribosomal scanning and start codon recognition (Bos taurus)
Ribosomal scanning (Bos taurus)
Pi [cytosol]
tRNA Aminoacylation (Bos taurus)
Cytosolic tRNA aminoacylation (Bos taurus)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Bos taurus)
Pi [cytosol]
Muscle contraction (Bos taurus)
Cardiac conduction (Bos taurus)
Ion homeostasis (Bos taurus)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Bos taurus)
Pi [cytosol]
Smooth Muscle Contraction (Bos taurus)
ATP Hydrolysis By Myosin (Bos taurus)
Pi [cytosol]
Striated Muscle Contraction (Bos taurus)
ATP Hydrolysis By Myosin (Bos taurus)
Pi [cytosol]
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter receptors and postsynaptic signal transmission (Bos taurus)
GABA receptor activation (Bos taurus)
GABA B receptor activation (Bos taurus)
Activation of GABAB receptors (Bos taurus)
Adenylate cyclase inhibitory pathway (Bos taurus)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Bos taurus)
Pi [cytosol]
Adenylate cyclase increases the GTPase activity of Gi alpha (Bos taurus)
Pi [cytosol]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Bos taurus)
Trafficking of AMPA receptors (Bos taurus)
Trafficking of GluR1-containing AMPA receptors (Bos taurus)
Pi [cytosol]
Trafficking of GluR2-containing AMPA receptors (Bos taurus)
Endocytosis of Ca impermeable AMPA receptors (Bos taurus)
Pi [cytosol]
Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Bos taurus)
Pi [cytosol]
Trafficking of GluR2-containing AMPA receptors to synapse (Bos taurus)
Pi [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Bos taurus)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Bos taurus)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Bos taurus)
Pi [cytosol]
Organelle biogenesis and maintenance (Bos taurus)
Cilium Assembly (Bos taurus)
Cargo trafficking to the periciliary membrane (Bos taurus)
VxPx cargo-targeting to cilium (Bos taurus)
ASAP1 stimulates GTPase activity of ARF4 (Bos taurus)
Pi [cytosol]
Programmed Cell Death (Bos taurus)
Apoptosis (Bos taurus)
Intrinsic Pathway for Apoptosis (Bos taurus)
Activation of BH3-only proteins (Bos taurus)
Activation of BAD and translocation to mitochondria (Bos taurus)
Activation of BAD by calcineurin (Bos taurus)
Pi [cytosol]
Sensory Perception (Bos taurus)
Visual phototransduction (Bos taurus)
The canonical retinoid cycle in rods (twilight vision) (Bos taurus)
ABCA4 mediates atRAL transport (Bos taurus)
Pi [cytosol]
The phototransduction cascade (Bos taurus)
Inactivation, recovery and regulation of the phototransduction cascade (Bos taurus)
GNAT1-GTP hydrolyses its bound GTP to GDP (Bos taurus)
Pi [cytosol]
PP2A dephosphorylates p-RHO to RHO (Bos taurus)
Pi [cytosol]
Signal Transduction (Bos taurus)
Integrin signaling (Bos taurus)
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
Pi [cytosol]
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PTEN dephosphorylates PIP3 (Bos taurus)
Pi [cytosol]
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF-independent MAPK1/3 activation (Bos taurus)
Cytosolic DUSPs dephosphorylate MAPKs (Bos taurus)
Pi [cytosol]
RAF/MAP kinase cascade (Bos taurus)
Negative regulation of MAPK pathway (Bos taurus)
Cytosolic DUSPs dephosphorylate MAPKs (Bos taurus)
Pi [cytosol]
PP2A dephosphorylates RAF1 (Bos taurus)
Pi [cytosol]
PP5 dephosphorylates RAF1 S338 (Bos taurus)
Pi [cytosol]
PTPN3 dephosphorylates MAPK12 (Bos taurus)
Pi [cytosol]
PTPN7 dephosphorylates p-T,Y-MAPKs (Bos taurus)
Pi [cytosol]
RAF activation (Bos taurus)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Bos taurus)
Pi [cytosol]
PP2A dephosphorylates KSR1 (Bos taurus)
Pi [cytosol]
PP2A dephosphorylates inactive RAFs (Bos taurus)
Pi [cytosol]
MTOR signalling (Bos taurus)
Energy dependent regulation of mTOR by LKB1-AMPK (Bos taurus)
AMPK is dephosphorylated (Bos taurus)
Pi [cytosol]
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Bos taurus)
Pi [cytosol]
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Bos taurus)
Pi [cytosol]
Opioid Signalling (Bos taurus)
DARPP-32 events (Bos taurus)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Bos taurus)
Pi [cytosol]
G-protein mediated events (Bos taurus)
Adenylate cyclase activating pathway (Bos taurus)
Adenylaye cyclase increases the GTPase activity of G alpha-olf (Bos taurus)
Pi [cytosol]
Adenylate cyclase inhibitory pathway (Bos taurus)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Bos taurus)
Pi [cytosol]
Adenylate cyclase increases the GTPase activity of Gi alpha (Bos taurus)
Pi [cytosol]
PLC beta mediated events (Bos taurus)
Inactivation of PLC beta (Bos taurus)
Pi [cytosol]
G alpha (q) signalling events (Bos taurus)
G alpha (q) in G (q):RGS complex is inactivated (Bos taurus)
Pi [cytosol]
G alpha (z) signalling events (Bos taurus)
G alpha (z) in G alpha (z):RGS complex is inactivated (Bos taurus)
Pi [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Bos taurus)
Signaling by PTK6 (Bos taurus)
PTK6 Down-Regulation (Bos taurus)
PTPN1 dephosphorylates PTK6 (Bos taurus)
Pi [cytosol]
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Bos taurus)
ARHGAP35 stimulates RHOA GTPase activity (Bos taurus)
Pi [cytosol]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ALK (Bos taurus)
MDK and PTN in ALK signaling (Bos taurus)
PTPRZ dephosphorylates ligand-bound ALK dimers (Bos taurus)
Pi [cytosol]
PTPN6 dephosphorylates JAK3 (Bos taurus)
Pi [cytosol]
Signaling by EGFR (Bos taurus)
EGFR downregulation (Bos taurus)
PTPN3 dephosphorylates EPS15 (Bos taurus)
Pi [cytosol]
GAB1 signalosome (Bos taurus)
Dephosphorylation of Gab1 by SHP2 (Bos taurus)
Pi [cytosol]
Dephosphorylation of PAG by SHP2 (Bos taurus)
Pi [cytosol]
SHP2 dephosphorylates Tyr 992 on EGFR (Bos taurus)
Pi [cytosol]
Sustained activation of SRC kinase by SHP2 (Bos taurus)
Pi [cytosol]
Signaling by ERBB2 (Bos taurus)
Downregulation of ERBB2 signaling (Bos taurus)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Bos taurus)
Pi [cytosol]
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Bos taurus)
Pi [cytosol]
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Negative regulation of FGFR1 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
PPA2A dephosphorylates SPRY2 (Bos taurus)
Pi [cytosol]
Signaling by FGFR2 (Bos taurus)
Negative regulation of FGFR2 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
PPA2A dephosphorylates SPRY2 (Bos taurus)
Pi [cytosol]
Signaling by FGFR3 (Bos taurus)
Negative regulation of FGFR3 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
PPA2A dephosphorylates SPRY2 (Bos taurus)
Pi [cytosol]
Signaling by FGFR4 (Bos taurus)
Negative regulation of FGFR4 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
PPA2A dephosphorylates SPRY2 (Bos taurus)
Pi [cytosol]
Signaling by Insulin receptor (Bos taurus)
Insulin receptor recycling (Bos taurus)
Insulin receptor de-phosphorylation (Bos taurus)
Pi [cytosol]
Signaling by MET (Bos taurus)
Negative regulation of MET activity (Bos taurus)
PTPN1 and PTPN2 dephosphorylate MET (Bos taurus)
Pi [cytosol]
PTPRJ dephosphorylates MET (Bos taurus)
Pi [cytosol]
Signaling by PDGF (Bos taurus)
PTPN12 dephosphorylates PDGFRB at Y1021 (Bos taurus)
Pi [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Miro GTPase Cycle (Bos taurus)
RHOT1 GTPase cycle (Bos taurus)
RHOT1 hydrolyzes GTP (Bos taurus)
Pi [cytosol]
RHOT2 GTPase cycle (Bos taurus)
RHOT2 hydrolyzes GTP (Bos taurus)
Pi [cytosol]
RHOBTB3 ATPase cycle (Bos taurus)
RHOBTB3 hydrolyzes ATP (Bos taurus)
Pi [cytosol]
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases Activate Formins (Bos taurus)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Bos taurus)
Pi [cytosol]
RHO GTPase cycle (Bos taurus)
CDC42 GTPase cycle (Bos taurus)
CDC42 GAPs stimulate CDC42 GTPase activity (Bos taurus)
Pi [cytosol]
RAC1 GTPase cycle (Bos taurus)
RAC1 GAPs stimulate RAC1 GTPase activity (Bos taurus)
Pi [cytosol]
RAC2 GTPase cycle (Bos taurus)
RAC2 GAPs stimulate RAC2 GTPase activity (Bos taurus)
Pi [cytosol]
RAC3 GTPase cycle (Bos taurus)
RAC3 GAPs stimulate RAC3 GTPase activity (Bos taurus)
Pi [cytosol]
RHOA GTPase cycle (Bos taurus)
RHOA GAPs stimulate RHOA GTPase activity (Bos taurus)
Pi [cytosol]
RHOC GTPase cycle (Bos taurus)
RHOC GAPs stimulate RHOC GTPase activity (Bos taurus)
Pi [cytosol]
RHOD GTPase cycle (Bos taurus)
RHOD GAPs stimulate RHOD GTPase activity (Bos taurus)
Pi [cytosol]
RHOF GTPase cycle (Bos taurus)
RHOF GAPs stimulate RHOF GTPase activity (Bos taurus)
Pi [cytosol]
RHOG GTPase cycle (Bos taurus)
RHOG GAPs stimulate RHOG GTPase activity (Bos taurus)
Pi [cytosol]
RHOJ GTPase cycle (Bos taurus)
RHOJ GAPs stimulate RHOJ GTPase activity (Bos taurus)
Pi [cytosol]
RHOQ GTPase cycle (Bos taurus)
RHOQ GAPs stimulate RHOQ GTPase activity (Bos taurus)
Pi [cytosol]
Signaling by TGFB family members (Bos taurus)
Signaling by TGF-beta Receptor Complex (Bos taurus)
TGF-beta receptor signaling activates SMADs (Bos taurus)
Downregulation of TGF-beta receptor signaling (Bos taurus)
MTMR4 dephosphorylates SMAD2/3 (Bos taurus)
Pi [cytosol]
Signaling by WNT (Bos taurus)
Beta-catenin independent WNT signaling (Bos taurus)
Ca2+ pathway (Bos taurus)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Bos taurus)
Pi [cytosol]
Transport of small molecules (Bos taurus)
ABC-family proteins mediated transport (Bos taurus)
ABC transporters in lipid homeostasis (Bos taurus)
ABCA12 transports lipids from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Bos taurus)
Pi [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Bos taurus)
Pi [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Bos taurus)
Pi [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Bos taurus)
Pi [cytosol]
ABCG4 may mediate cholesterol efflux (Bos taurus)
Pi [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
ABCA4 mediates atRAL transport (Bos taurus)
Pi [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Bos taurus)
Pi [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Bos taurus)
Pi [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
HCO3- transport through ion channel (Bos taurus)
Pi [cytosol]
Mitochondrial ABC transporters (Bos taurus)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Bos taurus)
Pi [cytosol]
The ABCC family mediates organic anion transport (Bos taurus)
Pi [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Bos taurus)
Pi [cytosol]
Ion channel transport (Bos taurus)
Ion transport by P-type ATPases (Bos taurus)
ATP12A:ATP4B exchanges K+ for H+ (Bos taurus)
Pi [cytosol]
ATP13A1 transports Mn2+ from cytosol to ER lumen (Bos taurus)
Pi [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Bos taurus)
Pi [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Bos taurus)
Pi [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Bos taurus)
Pi [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Bos taurus)
Pi [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Bos taurus)
Pi [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Bos taurus)
Pi [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Bos taurus)
Pi [cytosol]
Stimuli-sensing channels (Bos taurus)
SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Bos taurus)
Pi [cytosol]
Iron uptake and transport (Bos taurus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
Transferrin endocytosis and recycling (Bos taurus)
Acidification of Tf:TfR1 containing endosome (Bos taurus)
Pi [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Bos taurus)
Plasma lipoprotein assembly (Bos taurus)
HDL assembly (Bos taurus)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Bos taurus)
Pi [cytosol]
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Bos taurus)
Pi [cytosol]
Plasma lipoprotein remodeling (Bos taurus)
HDL remodeling (Bos taurus)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Bos taurus)
Pi [cytosol]
SLC-mediated transmembrane transport (Bos taurus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Bos taurus)
Organic anion transporters (Bos taurus)
SLC25A10 mediates exchange of malate and phosphate (Bos taurus)
Pi [cytosol]
Type I Na+-coupled phosphate co-transport (Bos taurus)
Pi [cytosol]
Sodium-coupled phosphate cotransporters (Bos taurus)
SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Bos taurus)
Pi [cytosol]
Type II Na+/Pi cotransporters (Bos taurus)
SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Bos taurus)
Pi [cytosol]
SLC34A3 cotransports Pi, 2Na+ (Bos taurus)
Pi [cytosol]
Vesicle-mediated transport (Bos taurus)
Membrane Trafficking (Bos taurus)
Clathrin-mediated endocytosis (Bos taurus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
Pi [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Bos taurus)
Pi [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
Pi [cytosol]
ER to Golgi Anterograde Transport (Bos taurus)
COPI-mediated anterograde transport (Bos taurus)
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Bos taurus)
Pi [cytosol]
COPII-mediated vesicle transport (Bos taurus)
Loss of SAR1B GTPase (Bos taurus)
Pi [cytosol]
NSF ATPase activity dissociates cis-SNARE (Bos taurus)
Pi [cytosol]
PP6 dephosphorylates SEC24 (Bos taurus)
Pi [cytosol]
Vesicle budding (Bos taurus)
Pi [cytosol]
Endosomal Sorting Complex Required For Transport (ESCRT) (Bos taurus)
ESCRT Disassembly (Bos taurus)
Pi [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Bos taurus)
Golgi-to-ER retrograde transport (Bos taurus)
COPI-dependent Golgi-to-ER retrograde traffic (Bos taurus)
NSF ATPase activity dissociates cis-SNARE at the ER (Bos taurus)
Pi [cytosol]
Rab regulation of trafficking (Bos taurus)
TBC/RABGAPs (Bos taurus)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Bos taurus)
Pi [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Bos taurus)
Pi [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Bos taurus)
Pi [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Bos taurus)
Pi [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Bos taurus)
Pi [cytosol]
trans-Golgi Network Vesicle Budding (Bos taurus)
Golgi Associated Vesicle Biogenesis (Bos taurus)
trans-Golgi Network Coat Assembly (Bos taurus)
Pi [cytosol]
trans-Golgi Network Vesicle Scission (Bos taurus)
Pi [cytosol]
Lysosome Vesicle Biogenesis (Bos taurus)
trans-Golgi Network Lysosomal Vesicle Scission (Bos taurus)
Pi [cytosol]
trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Bos taurus)
Pi [cytosol]
Autophagy (Caenorhabditis elegans)
Macroautophagy (Caenorhabditis elegans)
ULK1 is dephosphorylated (Caenorhabditis elegans)
Pi [cytosol]
Cell Cycle (Caenorhabditis elegans)
Cell Cycle, Mitotic (Caenorhabditis elegans)
M Phase (Caenorhabditis elegans)
Mitotic Metaphase and Anaphase (Caenorhabditis elegans)
Mitotic Anaphase (Caenorhabditis elegans)
Nuclear Envelope (NE) Reassembly (Caenorhabditis elegans)
Initiation of Nuclear Envelope (NE) Reformation (Caenorhabditis elegans)
PP2A dephosphorylates BANF1 (Caenorhabditis elegans)
Pi [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Caenorhabditis elegans)
RAN stimulates fusion of nuclear envelope (NE) membranes (Caenorhabditis elegans)
Pi [cytosol]
Mitotic Prometaphase (Caenorhabditis elegans)
Resolution of Sister Chromatid Cohesion (Caenorhabditis elegans)
PPP1CC dephosphorylates PLK1 (Caenorhabditis elegans)
Pi [cytosol]
Mitotic G2-G2/M phases (Caenorhabditis elegans)
G2/M Transition (Caenorhabditis elegans)
Cyclin A/B1/B2 associated events during G2/M transition (Caenorhabditis elegans)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Caenorhabditis elegans)
Pi [cytosol]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to mechanical stimuli (Caenorhabditis elegans)
Response of endothelial cells to shear stress (Caenorhabditis elegans)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Caenorhabditis elegans)
PP2A dephosphorylates serine-127 of YAP1 (Caenorhabditis elegans)
Pi [cytosol]
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to heat stress (Caenorhabditis elegans)
Regulation of HSF1-mediated heat shock response (Caenorhabditis elegans)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
Cellular response to starvation (Caenorhabditis elegans)
Amino acids regulate mTORC1 (Caenorhabditis elegans)
RRAGA,B hydrolyzes GTP (Caenorhabditis elegans)
Pi [cytosol]
RRAGC,D hydrolyzes GTP (Caenorhabditis elegans)
Pi [cytosol]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Caenorhabditis elegans)
ATP hydrolysis by HSP70 (Caenorhabditis elegans)
Pi [cytosol]
Developmental Biology (Caenorhabditis elegans)
Nervous system development (Caenorhabditis elegans)
Axon guidance (Caenorhabditis elegans)
EPH-Ephrin signaling (Caenorhabditis elegans)
EPHB-mediated forward signaling (Caenorhabditis elegans)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Caenorhabditis elegans)
Pi [cytosol]
L1CAM interactions (Caenorhabditis elegans)
Recycling pathway of L1 (Caenorhabditis elegans)
Formation of clathrin coated vesicle (Caenorhabditis elegans)
Pi [cytosol]
Semaphorin interactions (Caenorhabditis elegans)
Sema4D in semaphorin signaling (Caenorhabditis elegans)
Sema4D mediated inhibition of cell attachment and migration (Caenorhabditis elegans)
Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Caenorhabditis elegans)
Pi [cytosol]
Inactivation of Rho-GTP by p190RhoGAP (Caenorhabditis elegans)
Pi [cytosol]
Signaling by ROBO receptors (Caenorhabditis elegans)
SLIT2:ROBO1 increases RHOA activity (Caenorhabditis elegans)
MYO9B inactivates RHOA (Caenorhabditis elegans)
Pi [cytosol]
Drug ADME (Caenorhabditis elegans)
Aspirin ADME (Caenorhabditis elegans)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Caenorhabditis elegans)
Pi [cytosol]
Azathioprine ADME (Caenorhabditis elegans)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Caenorhabditis elegans)
Pi [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Caenorhabditis elegans)
Pi [cytosol]
Paracetamol ADME (Caenorhabditis elegans)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Caenorhabditis elegans)
Pi [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Caenorhabditis elegans)
Pi [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Caenorhabditis elegans)
Pi [cytosol]
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
Transcriptional Regulation by TP53 (Caenorhabditis elegans)
TP53 Regulates Metabolic Genes (Caenorhabditis elegans)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Caenorhabditis elegans)
Pi [cytosol]
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
Response to elevated platelet cytosolic Ca2+ (Caenorhabditis elegans)
Platelet degranulation (Caenorhabditis elegans)
ABCC4 accumulation of dense granule contents (Caenorhabditis elegans)
Pi [cytosol]
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Class I MHC mediated antigen processing & presentation (Caenorhabditis elegans)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Caenorhabditis elegans)
Transport of Antigen peptide in to ER (Caenorhabditis elegans)
Pi [cytosol]
Regulation of T cell activation by CD28 family (Caenorhabditis elegans)
Co-inhibition by CTLA4 (Caenorhabditis elegans)
Dephosphorylation of AKT by PP2A (Caenorhabditis elegans)
Pi [cytosol]
TCR signaling (Caenorhabditis elegans)
Downstream TCR signaling (Caenorhabditis elegans)
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
Pi [cytosol]
Metabolism (Caenorhabditis elegans)
Aerobic respiration and respiratory electron transport (Caenorhabditis elegans)
Pyruvate metabolism (Caenorhabditis elegans)
Regulation of pyruvate metabolism (Caenorhabditis elegans)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Caenorhabditis elegans)
Pi [cytosol]
Biological oxidations (Caenorhabditis elegans)
Phase II - Conjugation of compounds (Caenorhabditis elegans)
Cytosolic sulfonation of small molecules (Caenorhabditis elegans)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Caenorhabditis elegans)
Pi [cytosol]
Glutathione conjugation (Caenorhabditis elegans)
Glutathione synthesis and recycling (Caenorhabditis elegans)
GCL ligates L-Glu to L-Cys (Caenorhabditis elegans)
Pi [cytosol]
GSS:Mg2+ dimer synthesizes GSH (Caenorhabditis elegans)
Pi [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Caenorhabditis elegans)
Pi [cytosol]
Inositol phosphate metabolism (Caenorhabditis elegans)
Synthesis of IP2, IP, and Ins in the cytosol (Caenorhabditis elegans)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Caenorhabditis elegans)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
Synthesis of pyrophosphates in the cytosol (Caenorhabditis elegans)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Glutamate and glutamine metabolism (Caenorhabditis elegans)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Caenorhabditis elegans)
Pi [cytosol]
Selenoamino acid metabolism (Caenorhabditis elegans)
Selenocysteine synthesis (Caenorhabditis elegans)
SEPHS2 phosphorylates H2Se to form SELP (Caenorhabditis elegans)
Pi [cytosol]
Serine metabolism (Caenorhabditis elegans)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Caenorhabditis elegans)
Pi [cytosol]
Sulfur amino acid metabolism (Caenorhabditis elegans)
Methionine salvage pathway (Caenorhabditis elegans)
Acireductone is created (Caenorhabditis elegans)
Pi [cytosol]
MTA is cleaved and phosphorylated (Caenorhabditis elegans)
Pi [cytosol]
Metabolism of carbohydrates and carbohydrate derivatives (Caenorhabditis elegans)
Glucose metabolism (Caenorhabditis elegans)
Gluconeogenesis (Caenorhabditis elegans)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Caenorhabditis elegans)
Pi [cytosol]
GAPDH tetramers reduce 1,3BPG to GA3P (Caenorhabditis elegans)
Pi [cytosol]
SLC7A4 exchanges G6P for Pi across the ER membrane (Caenorhabditis elegans)
Pi [cytosol]
Glycolysis (Caenorhabditis elegans)
GADPH tetramer dehydrogenates GA3P (Caenorhabditis elegans)
Pi [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Caenorhabditis elegans)
PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (Caenorhabditis elegans)
Pi [cytosol]
Glycogen metabolism (Caenorhabditis elegans)
Glycogen synthesis (Caenorhabditis elegans)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Caenorhabditis elegans)
Pi [cytosol]
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Caenorhabditis elegans)
Pi [cytosol]
Metabolism of lipids (Caenorhabditis elegans)
Fatty acid metabolism (Caenorhabditis elegans)
Arachidonate metabolism (Caenorhabditis elegans)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Caenorhabditis elegans)
LTC4 is exported from the cytosol by ABCC1 (Caenorhabditis elegans)
Pi [cytosol]
Carnitine shuttle (Caenorhabditis elegans)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Caenorhabditis elegans)
Pi [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Caenorhabditis elegans)
Pi [cytosol]
Fatty acyl-CoA biosynthesis (Caenorhabditis elegans)
ACLY tetramer transforms CIT to Ac-CoA (Caenorhabditis elegans)
Pi [cytosol]
Formation of Malonyl-CoA from Acetyl-CoA (liver) (Caenorhabditis elegans)
Pi [cytosol]
Metabolism of steroids (Caenorhabditis elegans)
Bile acid and bile salt metabolism (Caenorhabditis elegans)
Recycling of bile acids and salts (Caenorhabditis elegans)
ABCC3 transports bile salts from cytosol to extracellular region (Caenorhabditis elegans)
Pi [cytosol]
Cholesterol biosynthesis (Caenorhabditis elegans)
MVD decarboxylates MVA5PP to IPPP (Caenorhabditis elegans)
Pi [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Caenorhabditis elegans)
Pi [cytosol]
Phospholipid metabolism (Caenorhabditis elegans)
Glycerophospholipid biosynthesis (Caenorhabditis elegans)
PGP:Mg2+ dimer hydrolyses G3P to glycerol (Caenorhabditis elegans)
Pi [cytosol]
Synthesis of PC (Caenorhabditis elegans)
PA is dephosphorylated to DAG by LPIN (Caenorhabditis elegans)
Pi [cytosol]
Synthesis of PE (Caenorhabditis elegans)
PA is dephosphorylated to DAG by LPIN (Caenorhabditis elegans)
Pi [cytosol]
PI Metabolism (Caenorhabditis elegans)
Synthesis of PIPs at the ER membrane (Caenorhabditis elegans)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Caenorhabditis elegans)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Caenorhabditis elegans)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Caenorhabditis elegans)
Pi [cytosol]
Synthesis of PIPs at the Golgi membrane (Caenorhabditis elegans)
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Caenorhabditis elegans)
Pi [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Caenorhabditis elegans)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Caenorhabditis elegans)
Pi [cytosol]
Synthesis of PIPs at the early endosome membrane (Caenorhabditis elegans)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Caenorhabditis elegans)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Caenorhabditis elegans)
Pi [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Caenorhabditis elegans)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Caenorhabditis elegans)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Caenorhabditis elegans)
Pi [cytosol]
Synthesis of PIPs at the late endosome membrane (Caenorhabditis elegans)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Caenorhabditis elegans)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Caenorhabditis elegans)
Pi [cytosol]
Synthesis of PIPs at the plasma membrane (Caenorhabditis elegans)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
Pi [cytosol]
Sphingolipid metabolism (Caenorhabditis elegans)
Sphingolipid catabolism (Caenorhabditis elegans)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Caenorhabditis elegans)
Pi [cytosol]
Sphingolipid de novo biosynthesis (Caenorhabditis elegans)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Caenorhabditis elegans)
Pi [cytosol]
Triglyceride metabolism (Caenorhabditis elegans)
Triglyceride biosynthesis (Caenorhabditis elegans)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Caenorhabditis elegans)
Pi [cytosol]
Metabolism of nucleotides (Caenorhabditis elegans)
Interconversion of nucleotide di- and triphosphates (Caenorhabditis elegans)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Caenorhabditis elegans)
Pi [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Caenorhabditis elegans)
Pi [cytosol]
Nucleotide biosynthesis (Caenorhabditis elegans)
Purine ribonucleoside monophosphate biosynthesis (Caenorhabditis elegans)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Caenorhabditis elegans)
Pi [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Caenorhabditis elegans)
Pi [cytosol]
FGAM + ATP => AIR + ADP + Pi (Caenorhabditis elegans)
Pi [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Caenorhabditis elegans)
Pi [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Caenorhabditis elegans)
Pi [cytosol]
Pyrimidine biosynthesis (Caenorhabditis elegans)
CAD hexamer transforms CAP to N-carb-L-Asp (Caenorhabditis elegans)
Pi [cytosol]
CAD hexamer transforms L-Gln to CAP (Caenorhabditis elegans)
Pi [cytosol]
Nucleotide catabolism (Caenorhabditis elegans)
Purine catabolism (Caenorhabditis elegans)
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Caenorhabditis elegans)
Pi [cytosol]
PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Caenorhabditis elegans)
Pi [cytosol]
PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Caenorhabditis elegans)
Pi [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Caenorhabditis elegans)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Caenorhabditis elegans)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Caenorhabditis elegans)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Caenorhabditis elegans)
Pi [cytosol]
Pyrimidine catabolism (Caenorhabditis elegans)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Caenorhabditis elegans)
Pi [cytosol]
(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Caenorhabditis elegans)
Pi [cytosol]
Nucleotide salvage (Caenorhabditis elegans)
Purine salvage (Caenorhabditis elegans)
PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Caenorhabditis elegans)
Pi [cytosol]
PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Caenorhabditis elegans)
Pi [cytosol]
Pyrimidine salvage (Caenorhabditis elegans)
HDHD1:Mg2+ dephosphorylates PURIDP (Caenorhabditis elegans)
Pi [cytosol]
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Caenorhabditis elegans)
Pi [cytosol]
Metabolism of porphyrins (Caenorhabditis elegans)
Heme biosynthesis (Caenorhabditis elegans)
ABCG2 tetramer transports heme from cytosol to extracellular region (Caenorhabditis elegans)
Pi [cytosol]
Heme degradation (Caenorhabditis elegans)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Caenorhabditis elegans)
Pi [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Caenorhabditis elegans)
Pi [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Caenorhabditis elegans)
Transport of RCbl within the body (Caenorhabditis elegans)
ABCC1 transports cytosolic RCbl to extracellular region (Caenorhabditis elegans)
Pi [cytosol]
Metabolism of folate and pterines (Caenorhabditis elegans)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Caenorhabditis elegans)
Pi [cytosol]
FPGS-2 transforms THF to THFPG (Caenorhabditis elegans)
Pi [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Caenorhabditis elegans)
Pi [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Caenorhabditis elegans)
Pi [cytosol]
Nicotinate metabolism (Caenorhabditis elegans)
Nicotinamide salvage (Caenorhabditis elegans)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Caenorhabditis elegans)
Pi [cytosol]
Vitamin B2 (riboflavin) metabolism (Caenorhabditis elegans)
2xTRAP hydrolyzes FMN to RIB (Caenorhabditis elegans)
Pi [cytosol]
Vitamin B5 (pantothenate) metabolism (Caenorhabditis elegans)
PANK4 hydrolyzes PPANT to pantetheine (Caenorhabditis elegans)
Pi [cytosol]
Pyrophosphate hydrolysis (Caenorhabditis elegans)
LHPP:Mg2+ dimer hydrolyses PPi (Caenorhabditis elegans)
Pi [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Caenorhabditis elegans)
Pi [cytosol]
Metabolism of RNA (Caenorhabditis elegans)
Deadenylation-dependent mRNA decay (Caenorhabditis elegans)
mRNA decay by 3' to 5' exoribonuclease (Caenorhabditis elegans)
NT5C3B hydrolyses 7MGP to 7MG (Caenorhabditis elegans)
Pi [cytosol]
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Asparagine N-linked glycosylation (Caenorhabditis elegans)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Caenorhabditis elegans)
Synthesis of substrates in N-glycan biosythesis (Caenorhabditis elegans)
Synthesis of dolichyl-phosphate (Caenorhabditis elegans)
MVD decarboxylates MVA5PP to IPPP (Caenorhabditis elegans)
Pi [cytosol]
Transport to the Golgi and subsequent modification (Caenorhabditis elegans)
ER to Golgi Anterograde Transport (Caenorhabditis elegans)
COPII-mediated vesicle transport (Caenorhabditis elegans)
Loss of SAR1B GTPase (Caenorhabditis elegans)
Pi [cytosol]
NSF ATPase activity dissociates cis-SNARE (Caenorhabditis elegans)
Pi [cytosol]
Vesicle budding (Caenorhabditis elegans)
Pi [cytosol]
Protein folding (Caenorhabditis elegans)
Chaperonin-mediated protein folding (Caenorhabditis elegans)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Caenorhabditis elegans)
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Caenorhabditis elegans)
Pi [cytosol]
Surfactant metabolism (Caenorhabditis elegans)
ABCA3 transports PC, PG from ER membrane to lamellar body (Caenorhabditis elegans)
Pi [cytosol]
SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Caenorhabditis elegans)
Pi [cytosol]
Translation (Caenorhabditis elegans)
Eukaryotic Translation Initiation (Caenorhabditis elegans)
Cap-dependent Translation Initiation (Caenorhabditis elegans)
GTP hydrolysis and joining of the 60S ribosomal subunit (Caenorhabditis elegans)
eIF5B:GTP is hydrolyzed and released (Caenorhabditis elegans)
Pi [cytosol]
Ribosomal scanning and start codon recognition (Caenorhabditis elegans)
Ribosomal scanning (Caenorhabditis elegans)
Pi [cytosol]
tRNA Aminoacylation (Caenorhabditis elegans)
Cytosolic tRNA aminoacylation (Caenorhabditis elegans)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Caenorhabditis elegans)
Pi [cytosol]
Muscle contraction (Caenorhabditis elegans)
Smooth Muscle Contraction (Caenorhabditis elegans)
ATP Hydrolysis By Myosin (Caenorhabditis elegans)
Pi [cytosol]
Neuronal System (Caenorhabditis elegans)
Transmission across Chemical Synapses (Caenorhabditis elegans)
Neurotransmitter receptors and postsynaptic signal transmission (Caenorhabditis elegans)
GABA receptor activation (Caenorhabditis elegans)
GABA B receptor activation (Caenorhabditis elegans)
Activation of GABAB receptors (Caenorhabditis elegans)
Adenylate cyclase inhibitory pathway (Caenorhabditis elegans)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Caenorhabditis elegans)
Pi [cytosol]
Adenylate cyclase increases the GTPase activity of Gi alpha (Caenorhabditis elegans)
Pi [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Caenorhabditis elegans)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Caenorhabditis elegans)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Caenorhabditis elegans)
Pi [cytosol]
Sensory Perception (Caenorhabditis elegans)
Visual phototransduction (Caenorhabditis elegans)
The canonical retinoid cycle in rods (twilight vision) (Caenorhabditis elegans)
ABCA4 mediates atRAL transport (Caenorhabditis elegans)
Pi [cytosol]
The phototransduction cascade (Caenorhabditis elegans)
Inactivation, recovery and regulation of the phototransduction cascade (Caenorhabditis elegans)
PP2A dephosphorylates p-RHO to RHO (Caenorhabditis elegans)
Pi [cytosol]
Signal Transduction (Caenorhabditis elegans)
Intracellular signaling by second messengers (Caenorhabditis elegans)
PIP3 activates AKT signaling (Caenorhabditis elegans)
Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Caenorhabditis elegans)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Caenorhabditis elegans)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
Pi [cytosol]
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF-independent MAPK1/3 activation (Caenorhabditis elegans)
Cytosolic DUSPs dephosphorylate MAPKs (Caenorhabditis elegans)
Pi [cytosol]
RAF/MAP kinase cascade (Caenorhabditis elegans)
Negative regulation of MAPK pathway (Caenorhabditis elegans)
Cytosolic DUSPs dephosphorylate MAPKs (Caenorhabditis elegans)
Pi [cytosol]
PP2A dephosphorylates RAF1 (Caenorhabditis elegans)
Pi [cytosol]
PP5 dephosphorylates RAF1 S338 (Caenorhabditis elegans)
Pi [cytosol]
PTPN3 dephosphorylates MAPK12 (Caenorhabditis elegans)
Pi [cytosol]
RAF activation (Caenorhabditis elegans)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Caenorhabditis elegans)
Pi [cytosol]
PP2A dephosphorylates KSR1 (Caenorhabditis elegans)
Pi [cytosol]
PP2A dephosphorylates inactive RAFs (Caenorhabditis elegans)
Pi [cytosol]
MTOR signalling (Caenorhabditis elegans)
Energy dependent regulation of mTOR by LKB1-AMPK (Caenorhabditis elegans)
AMPK is dephosphorylated (Caenorhabditis elegans)
Pi [cytosol]
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Caenorhabditis elegans)
Pi [cytosol]
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (i) signalling events (Caenorhabditis elegans)
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Caenorhabditis elegans)
Pi [cytosol]
Opioid Signalling (Caenorhabditis elegans)
G-protein mediated events (Caenorhabditis elegans)
Adenylate cyclase activating pathway (Caenorhabditis elegans)
Adenylaye cyclase increases the GTPase activity of G alpha-olf (Caenorhabditis elegans)
Pi [cytosol]
Adenylate cyclase inhibitory pathway (Caenorhabditis elegans)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Caenorhabditis elegans)
Pi [cytosol]
Adenylate cyclase increases the GTPase activity of Gi alpha (Caenorhabditis elegans)
Pi [cytosol]
PLC beta mediated events (Caenorhabditis elegans)
Inactivation of PLC beta (Caenorhabditis elegans)
Pi [cytosol]
G alpha (q) signalling events (Caenorhabditis elegans)
G alpha (q) in G (q):RGS complex is inactivated (Caenorhabditis elegans)
Pi [cytosol]
G alpha (z) signalling events (Caenorhabditis elegans)
G alpha (z) in G alpha (z):RGS complex is inactivated (Caenorhabditis elegans)
Pi [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by PTK6 (Caenorhabditis elegans)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Caenorhabditis elegans)
ARHGAP35 stimulates RHOA GTPase activity (Caenorhabditis elegans)
Pi [cytosol]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by EGFR (Caenorhabditis elegans)
EGFR downregulation (Caenorhabditis elegans)
PTPN3 dephosphorylates EPS15 (Caenorhabditis elegans)
Pi [cytosol]
Signaling by ERBB2 (Caenorhabditis elegans)
Downregulation of ERBB2 signaling (Caenorhabditis elegans)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Caenorhabditis elegans)
Pi [cytosol]
Signaling by MET (Caenorhabditis elegans)
Negative regulation of MET activity (Caenorhabditis elegans)
PTPRJ dephosphorylates MET (Caenorhabditis elegans)
Pi [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Caenorhabditis elegans)
Miro GTPase Cycle (Caenorhabditis elegans)
RHOT1 GTPase cycle (Caenorhabditis elegans)
RHOT1 hydrolyzes GTP (Caenorhabditis elegans)
Pi [cytosol]
RHOT2 GTPase cycle (Caenorhabditis elegans)
RHOT2 hydrolyzes GTP (Caenorhabditis elegans)
Pi [cytosol]
RHOBTB3 ATPase cycle (Caenorhabditis elegans)
RHOBTB3 hydrolyzes ATP (Caenorhabditis elegans)
Pi [cytosol]
Signaling by Rho GTPases (Caenorhabditis elegans)
RHO GTPase cycle (Caenorhabditis elegans)
CDC42 GTPase cycle (Caenorhabditis elegans)
CDC42 GAPs stimulate CDC42 GTPase activity (Caenorhabditis elegans)
Pi [cytosol]
RAC1 GTPase cycle (Caenorhabditis elegans)
RAC1 GAPs stimulate RAC1 GTPase activity (Caenorhabditis elegans)
Pi [cytosol]
RAC2 GTPase cycle (Caenorhabditis elegans)
RAC2 GAPs stimulate RAC2 GTPase activity (Caenorhabditis elegans)
Pi [cytosol]
RAC3 GTPase cycle (Caenorhabditis elegans)
RAC3 GAPs stimulate RAC3 GTPase activity (Caenorhabditis elegans)
Pi [cytosol]
RHOA GTPase cycle (Caenorhabditis elegans)
RHOA GAPs stimulate RHOA GTPase activity (Caenorhabditis elegans)
Pi [cytosol]
RHOB GTPase cycle (Caenorhabditis elegans)
RHOB GAPs stimulate RHOB GTPase activity (Caenorhabditis elegans)
Pi [cytosol]
RHOD GTPase cycle (Caenorhabditis elegans)
RHOD GAPs stimulate RHOD GTPase activity (Caenorhabditis elegans)
Pi [cytosol]
RHOF GTPase cycle (Caenorhabditis elegans)
RHOF GAPs stimulate RHOF GTPase activity (Caenorhabditis elegans)
Pi [cytosol]
RHOG GTPase cycle (Caenorhabditis elegans)
RHOG GAPs stimulate RHOG GTPase activity (Caenorhabditis elegans)
Pi [cytosol]
RHOJ GTPase cycle (Caenorhabditis elegans)
RHOJ GAPs stimulate RHOJ GTPase activity (Caenorhabditis elegans)
Pi [cytosol]
RHOQ GTPase cycle (Caenorhabditis elegans)
RHOQ GAPs stimulate RHOQ GTPase activity (Caenorhabditis elegans)
Pi [cytosol]
Transport of small molecules (Caenorhabditis elegans)
ABC-family proteins mediated transport (Caenorhabditis elegans)
ABC transporters in lipid homeostasis (Caenorhabditis elegans)
ABCA12 transports lipids from cytosol to extracellular region (Caenorhabditis elegans)
Pi [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Caenorhabditis elegans)
Pi [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Caenorhabditis elegans)
Pi [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Caenorhabditis elegans)
Pi [cytosol]
ABCA4 mediates atRAL transport (Caenorhabditis elegans)
Pi [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Caenorhabditis elegans)
Pi [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Caenorhabditis elegans)
Pi [cytosol]
HCO3- transport through ion channel (Caenorhabditis elegans)
Pi [cytosol]
Mitochondrial ABC transporters (Caenorhabditis elegans)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Caenorhabditis elegans)
Pi [cytosol]
The ABCC family mediates organic anion transport (Caenorhabditis elegans)
Pi [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Caenorhabditis elegans)
Pi [cytosol]
Ion channel transport (Caenorhabditis elegans)
Ion transport by P-type ATPases (Caenorhabditis elegans)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Caenorhabditis elegans)
Pi [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Caenorhabditis elegans)
Pi [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Caenorhabditis elegans)
Pi [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Caenorhabditis elegans)
Pi [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
Stimuli-sensing channels (Caenorhabditis elegans)
SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Caenorhabditis elegans)
Pi [cytosol]
Iron uptake and transport (Caenorhabditis elegans)
ABCG2 tetramer transports heme from cytosol to extracellular region (Caenorhabditis elegans)
Pi [cytosol]
Transferrin endocytosis and recycling (Caenorhabditis elegans)
Acidification of Tf:TfR1 containing endosome (Caenorhabditis elegans)
Pi [cytosol]
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of inorganic cations/anions and amino acids/oligopeptides (Caenorhabditis elegans)
Organic anion transporters (Caenorhabditis elegans)
SLC25A10 mediates exchange of malate and phosphate (Caenorhabditis elegans)
Pi [cytosol]
Type I Na+-coupled phosphate co-transport (Caenorhabditis elegans)
Pi [cytosol]
Sodium-coupled phosphate cotransporters (Caenorhabditis elegans)
SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Caenorhabditis elegans)
Pi [cytosol]
Type II Na+/Pi cotransporters (Caenorhabditis elegans)
SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Caenorhabditis elegans)
Pi [cytosol]
SLC34A3 cotransports Pi, 2Na+ (Caenorhabditis elegans)
Pi [cytosol]
Vesicle-mediated transport (Caenorhabditis elegans)
Membrane Trafficking (Caenorhabditis elegans)
Clathrin-mediated endocytosis (Caenorhabditis elegans)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
Pi [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Caenorhabditis elegans)
Pi [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
Pi [cytosol]
ER to Golgi Anterograde Transport (Caenorhabditis elegans)
COPII-mediated vesicle transport (Caenorhabditis elegans)
Loss of SAR1B GTPase (Caenorhabditis elegans)
Pi [cytosol]
NSF ATPase activity dissociates cis-SNARE (Caenorhabditis elegans)
Pi [cytosol]
Vesicle budding (Caenorhabditis elegans)
Pi [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Caenorhabditis elegans)
Golgi-to-ER retrograde transport (Caenorhabditis elegans)
COPI-dependent Golgi-to-ER retrograde traffic (Caenorhabditis elegans)
NSF ATPase activity dissociates cis-SNARE at the ER (Caenorhabditis elegans)
Pi [cytosol]
Rab regulation of trafficking (Caenorhabditis elegans)
TBC/RABGAPs (Caenorhabditis elegans)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Caenorhabditis elegans)
Pi [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Caenorhabditis elegans)
Pi [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Caenorhabditis elegans)
Pi [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Caenorhabditis elegans)
Pi [cytosol]
trans-Golgi Network Vesicle Budding (Caenorhabditis elegans)
Golgi Associated Vesicle Biogenesis (Caenorhabditis elegans)
trans-Golgi Network Coat Assembly (Caenorhabditis elegans)
Pi [cytosol]
trans-Golgi Network Vesicle Scission (Caenorhabditis elegans)
Pi [cytosol]
Lysosome Vesicle Biogenesis (Caenorhabditis elegans)
trans-Golgi Network Lysosomal Vesicle Scission (Caenorhabditis elegans)
Pi [cytosol]
trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Caenorhabditis elegans)
Pi [cytosol]
Autophagy (Canis familiaris)
Macroautophagy (Canis familiaris)
ULK1 is dephosphorylated (Canis familiaris)
Pi [cytosol]
Cell Cycle (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
M Phase (Canis familiaris)
Mitotic Metaphase and Anaphase (Canis familiaris)
Mitotic Anaphase (Canis familiaris)
Nuclear Envelope (NE) Reassembly (Canis familiaris)
Initiation of Nuclear Envelope (NE) Reformation (Canis familiaris)
PP2A dephosphorylates BANF1 (Canis familiaris)
Pi [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Canis familiaris)
RAN stimulates fusion of nuclear envelope (NE) membranes (Canis familiaris)
Pi [cytosol]
Sealing of the nuclear envelope (NE) by ESCRT-III (Canis familiaris)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Canis familiaris)
Pi [cytosol]
Mitotic Prometaphase (Canis familiaris)
Condensation of Prometaphase Chromosomes (Canis familiaris)
Dephosphorylation of CK2-modified condensin I (Canis familiaris)
Pi [cytosol]
Resolution of Sister Chromatid Cohesion (Canis familiaris)
PP2A-B56 dephosphorylates centromeric cohesin (Canis familiaris)
Pi [cytosol]
PPP1CC dephosphorylates PLK1 (Canis familiaris)
Pi [cytosol]
Mitotic G2-G2/M phases (Canis familiaris)
G2/M Transition (Canis familiaris)
Cyclin A/B1/B2 associated events during G2/M transition (Canis familiaris)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Canis familiaris)
Pi [cytosol]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to mechanical stimuli (Canis familiaris)
Response of endothelial cells to shear stress (Canis familiaris)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Canis familiaris)
PP2A dephosphorylates serine-127 of YAP1 (Canis familiaris)
Pi [cytosol]
PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) (Canis familiaris)
Pi [cytosol]
Cellular responses to stress (Canis familiaris)
Cellular response to heat stress (Canis familiaris)
Regulation of HSF1-mediated heat shock response (Canis familiaris)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Canis familiaris)
Pi [cytosol]
Cellular response to starvation (Canis familiaris)
Amino acids regulate mTORC1 (Canis familiaris)
RRAGA,B hydrolyzes GTP (Canis familiaris)
Pi [cytosol]
RRAGC,D hydrolyzes GTP (Canis familiaris)
Pi [cytosol]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Canis familiaris)
ATP hydrolysis by HSP70 (Canis familiaris)
Pi [cytosol]
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
EPH-Ephrin signaling (Canis familiaris)
EPHB-mediated forward signaling (Canis familiaris)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Canis familiaris)
Pi [cytosol]
L1CAM interactions (Canis familiaris)
Recycling pathway of L1 (Canis familiaris)
Formation of clathrin coated vesicle (Canis familiaris)
Pi [cytosol]
Semaphorin interactions (Canis familiaris)
Sema4D in semaphorin signaling (Canis familiaris)
Sema4D mediated inhibition of cell attachment and migration (Canis familiaris)
Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Canis familiaris)
Pi [cytosol]
Inactivation of Rho-GTP by p190RhoGAP (Canis familiaris)
Pi [cytosol]
Signaling by ROBO receptors (Canis familiaris)
SLIT2:ROBO1 increases RHOA activity (Canis familiaris)
MYO9B inactivates RHOA (Canis familiaris)
Pi [cytosol]
Drug ADME (Canis familiaris)
Aspirin ADME (Canis familiaris)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Canis familiaris)
Pi [cytosol]
Azathioprine ADME (Canis familiaris)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Canis familiaris)
Pi [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Canis familiaris)
Pi [cytosol]
Paracetamol ADME (Canis familiaris)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Canis familiaris)
Pi [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Canis familiaris)
Pi [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Canis familiaris)
Pi [cytosol]
Prednisone ADME (Canis familiaris)
ABCB1 transports PREDN,PREDL out of hepatic cells (Canis familiaris)
Pi [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Canis familiaris)
Pi [cytosol]
ABCB1 transports xenobiotics out of the cell (Canis familiaris)
Pi [cytosol]
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
TP53 Regulates Metabolic Genes (Canis familiaris)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Canis familiaris)
Pi [cytosol]
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Canis familiaris)
Pi [cytosol]
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
Platelet Aggregation (Plug Formation) (Canis familiaris)
Integrin signaling (Canis familiaris)
Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
Pi [cytosol]
Response to elevated platelet cytosolic Ca2+ (Canis familiaris)
Platelet degranulation (Canis familiaris)
ABCC4 accumulation of dense granule contents (Canis familiaris)
Pi [cytosol]
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
MHC class II antigen presentation (Canis familiaris)
Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Canis familiaris)
Pi [cytosol]
Internalization of MHC II:Ii clathrin coated vesicle (Canis familiaris)
Pi [cytosol]
Translocation of TGN-lysosome vesicle to lysosome (Canis familiaris)
Pi [cytosol]
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
Hydrolysis of PIP3 to PI(3,4)P2 (Canis familiaris)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Canis familiaris)
Pi [cytosol]
Phosphorylation of CD3 and TCR zeta chains (Canis familiaris)
Dephosphorylation of Lck-pY505 by CD45 (Canis familiaris)
Pi [cytosol]
Inactivation of LCK by PTPN22 (Canis familiaris)
Pi [cytosol]
Translocation of ZAP-70 to Immunological synapse (Canis familiaris)
PTPN22 dephosphorylates ZAP70 (Canis familiaris)
Pi [cytosol]
Cytokine Signaling in Immune system (Canis familiaris)
FLT3 Signaling (Canis familiaris)
Negative regulation of FLT3 (Canis familiaris)
PTPRJ dephosphorylates active FLT3 (Canis familiaris)
Pi [cytosol]
Growth hormone receptor signaling (Canis familiaris)
PTP1B dephosphorylates GHR (Canis familiaris)
Pi [cytosol]
Interferon Signaling (Canis familiaris)
Interferon alpha/beta signaling (Canis familiaris)
Regulation of IFNA/IFNB signaling (Canis familiaris)
Dephosphorylation of JAK1 by SHP1 (Canis familiaris)
Pi [cytosol]
Dephosphorylation of STAT1 by SHP2 (Canis familiaris)
Pi [cytosol]
Dephosphorylation of TYK2 by PTP1B (Canis familiaris)
Pi [cytosol]
Signaling by CSF3 (G-CSF) (Canis familiaris)
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Canis familiaris)
Pi [cytosol]
Innate Immune System (Canis familiaris)
Antimicrobial peptides (Canis familiaris)
Ion influx/efflux at host-pathogen interface (Canis familiaris)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Canis familiaris)
Pi [cytosol]
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
CLEC7A (Dectin-1) induces NFAT activation (Canis familiaris)
Calcineurin binds and dephosphorylates NFAT (Canis familiaris)
Pi [cytosol]
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Calcineurin binds and dephosphorylates NFAT (Canis familiaris)
Pi [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
Extension of pseudopodia by myosin-X in a PI3K dependent manner (Canis familiaris)
Pi [cytosol]
Role of myosins in phagosome formation (Canis familiaris)
Pi [cytosol]
Role of phospholipids in phagocytosis (Canis familiaris)
Conversion of PA into DAG by PAP-1 (Canis familiaris)
Pi [cytosol]
Metabolism (Canis familiaris)
Aerobic respiration and respiratory electron transport (Canis familiaris)
Pyruvate metabolism (Canis familiaris)
Regulation of pyruvate metabolism (Canis familiaris)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Canis familiaris)
Pi [cytosol]
Biological oxidations (Canis familiaris)
Phase II - Conjugation of compounds (Canis familiaris)
Cytosolic sulfonation of small molecules (Canis familiaris)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Canis familiaris)
Pi [cytosol]
Glutathione conjugation (Canis familiaris)
Glutathione synthesis and recycling (Canis familiaris)
GCL ligates L-Glu to L-Cys (Canis familiaris)
Pi [cytosol]
GSS:Mg2+ dimer synthesizes GSH (Canis familiaris)
Pi [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Canis familiaris)
Pi [cytosol]
Methylation (Canis familiaris)
MAT1A multimers transfer Ado from ATP to L-Met (Canis familiaris)
Pi [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Canis familiaris)
Pi [cytosol]
Inositol phosphate metabolism (Canis familiaris)
Synthesis of IP2, IP, and Ins in the cytosol (Canis familiaris)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Canis familiaris)
Pi [cytosol]
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Canis familiaris)
Pi [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Canis familiaris)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Canis familiaris)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Canis familiaris)
Pi [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Canis familiaris)
Pi [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)
Pi [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)
Pi [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)
Pi [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Canis familiaris)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Canis familiaris)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Canis familiaris)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Canis familiaris)
Pi [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Canis familiaris)
Pi [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Canis familiaris)
Pi [cytosol]
Synthesis of pyrophosphates in the cytosol (Canis familiaris)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)
Pi [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)
Pi [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)
Pi [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)
Pi [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Canis familiaris)
Pi [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Canis familiaris)
Pi [cytosol]
Metabolism of amino acids and derivatives (Canis familiaris)
Glutamate and glutamine metabolism (Canis familiaris)
N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Canis familiaris)
Pi [cytosol]
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Canis familiaris)
Pi [cytosol]
Histidine catabolism (Canis familiaris)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Canis familiaris)
Pi [cytosol]
Selenoamino acid metabolism (Canis familiaris)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Canis familiaris)
SeMet is converted to AdoSeMet by MAT (Canis familiaris)
Pi [cytosol]
Selenocysteine synthesis (Canis familiaris)
SEPHS2 phosphorylates H2Se to form SELP (Canis familiaris)
Pi [cytosol]
Serine metabolism (Canis familiaris)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Canis familiaris)
Pi [cytosol]
Sulfur amino acid metabolism (Canis familiaris)
MAT1A multimers transfer Ado from ATP to L-Met (Canis familiaris)
Pi [cytosol]
Methionine salvage pathway (Canis familiaris)
Acireductone is created (Canis familiaris)
Pi [cytosol]
MTA is cleaved and phosphorylated (Canis familiaris)
Pi [cytosol]
Metabolism of carbohydrates and carbohydrate derivatives (Canis familiaris)
Glucose metabolism (Canis familiaris)
Gluconeogenesis (Canis familiaris)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Canis familiaris)
Pi [cytosol]
GAPDH tetramers reduce 1,3BPG to GA3P (Canis familiaris)
Pi [cytosol]
SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Canis familiaris)
Pi [cytosol]
SLC7A4 exchanges G6P for Pi across the ER membrane (Canis familiaris)
Pi [cytosol]
Glycolysis (Canis familiaris)
GADPH tetramer dehydrogenates GA3P (Canis familiaris)
Pi [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Canis familiaris)
PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (Canis familiaris)
Pi [cytosol]
Glycogen metabolism (Canis familiaris)
Glycogen breakdown (glycogenolysis) (Canis familiaris)
glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Canis familiaris)
Pi [cytosol]
poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Canis familiaris)
Pi [cytosol]
Glycogen synthesis (Canis familiaris)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Canis familiaris)
Pi [cytosol]
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Canis familiaris)
Pi [cytosol]
Pentose phosphate pathway (Canis familiaris)
5-Phosphoribose 1-diphosphate biosynthesis (Canis familiaris)
PRPS dimers pyrophosphorylate R5P using ATP (Canis familiaris)
Pi [cytosol]
PRPS1 dimer pyrophosphorylates R5P using dATP (Canis familiaris)
Pi [cytosol]
Metabolism of lipids (Canis familiaris)
Fatty acid metabolism (Canis familiaris)
Arachidonate metabolism (Canis familiaris)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Canis familiaris)
LTC4 is exported from the cytosol by ABCC1 (Canis familiaris)
Pi [cytosol]
Carnitine shuttle (Canis familiaris)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Canis familiaris)
Pi [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Canis familiaris)
Pi [cytosol]
Fatty acyl-CoA biosynthesis (Canis familiaris)
ACLY tetramer transforms CIT to Ac-CoA (Canis familiaris)
Pi [cytosol]
Formation of Malonyl-CoA from Acetyl-CoA (liver) (Canis familiaris)
Pi [cytosol]
Metabolism of steroids (Canis familiaris)
Bile acid and bile salt metabolism (Canis familiaris)
Recycling of bile acids and salts (Canis familiaris)
ABCB11 transports bile salts from cytosol to extracellular region (Canis familiaris)
Pi [cytosol]
ABCC3 transports bile salts from cytosol to extracellular region (Canis familiaris)
Pi [cytosol]
Synthesis of bile acids and bile salts (Canis familiaris)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Canis familiaris)
ABCB11 transports bile salts from cytosol to extracellular region (Canis familiaris)
Pi [cytosol]
Cholesterol biosynthesis (Canis familiaris)
MVD decarboxylates MVA5PP to IPPP (Canis familiaris)
Pi [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Canis familiaris)
Pi [cytosol]
Phospholipid metabolism (Canis familiaris)
Glycerophospholipid biosynthesis (Canis familiaris)
PGP:Mg2+ dimer hydrolyses G3P to glycerol (Canis familiaris)
Pi [cytosol]
Synthesis of PC (Canis familiaris)
PA is dephosphorylated to DAG by LPIN (Canis familiaris)
Pi [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Canis familiaris)
Pi [cytosol]
Synthesis of PE (Canis familiaris)
PA is dephosphorylated to DAG by LPIN (Canis familiaris)
Pi [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Canis familiaris)
Pi [cytosol]
PI Metabolism (Canis familiaris)
Synthesis of PIPs at the ER membrane (Canis familiaris)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Canis familiaris)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Canis familiaris)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Canis familiaris)
Pi [cytosol]
Synthesis of PIPs at the Golgi membrane (Canis familiaris)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Canis familiaris)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Canis familiaris)
Pi [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Canis familiaris)
Pi [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Canis familiaris)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Canis familiaris)
Pi [cytosol]
Synthesis of PIPs at the early endosome membrane (Canis familiaris)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Canis familiaris)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Canis familiaris)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Canis familiaris)
Pi [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Canis familiaris)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Canis familiaris)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Canis familiaris)
Pi [cytosol]
Synthesis of PIPs at the late endosome membrane (Canis familiaris)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Canis familiaris)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Canis familiaris)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Canis familiaris)
Pi [cytosol]
Synthesis of PIPs at the plasma membrane (Canis familiaris)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Canis familiaris)
Pi [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Canis familiaris)
Pi [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Canis familiaris)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Canis familiaris)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Canis familiaris)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Canis familiaris)
Pi [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Canis familiaris)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Canis familiaris)
Pi [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Canis familiaris)
Pi [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Canis familiaris)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Canis familiaris)
Pi [cytosol]
Sphingolipid metabolism (Canis familiaris)
Sphingolipid catabolism (Canis familiaris)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Canis familiaris)
Pi [cytosol]
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Canis familiaris)
Pi [cytosol]
Sphingolipid de novo biosynthesis (Canis familiaris)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Canis familiaris)
Pi [cytosol]
Triglyceride metabolism (Canis familiaris)
Triglyceride biosynthesis (Canis familiaris)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Canis familiaris)
Pi [cytosol]
Metabolism of nucleotides (Canis familiaris)
Interconversion of nucleotide di- and triphosphates (Canis familiaris)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Canis familiaris)
Pi [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Canis familiaris)
Pi [cytosol]
Nucleotide biosynthesis (Canis familiaris)
Purine ribonucleoside monophosphate biosynthesis (Canis familiaris)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Canis familiaris)
Pi [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Canis familiaris)
Pi [cytosol]
FGAM + ATP => AIR + ADP + Pi (Canis familiaris)
Pi [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Canis familiaris)
Pi [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Canis familiaris)
Pi [cytosol]
Pyrimidine biosynthesis (Canis familiaris)
CAD hexamer transforms CAP to N-carb-L-Asp (Canis familiaris)
Pi [cytosol]
CAD hexamer transforms L-Gln to CAP (Canis familiaris)
Pi [cytosol]
Nucleotide catabolism (Canis familiaris)
Purine catabolism (Canis familiaris)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Canis familiaris)
Pi [cytosol]
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Canis familiaris)
Pi [cytosol]
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Canis familiaris)
Pi [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Canis familiaris)
Pi [cytosol]
PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Canis familiaris)
Pi [cytosol]
PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Canis familiaris)
Pi [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Canis familiaris)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Canis familiaris)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Canis familiaris)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)
Pi [cytosol]
Pyrimidine catabolism (Canis familiaris)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Canis familiaris)
Pi [cytosol]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Canis familiaris)
Pi [cytosol]
(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Canis familiaris)
Pi [cytosol]
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Canis familiaris)
Pi [cytosol]
Nucleotide salvage (Canis familiaris)
Purine salvage (Canis familiaris)
PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Canis familiaris)
Pi [cytosol]
PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Canis familiaris)
Pi [cytosol]
Pyrimidine salvage (Canis familiaris)
HDHD1:Mg2+ dephosphorylates PURIDP (Canis familiaris)
Pi [cytosol]
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Canis familiaris)
Pi [cytosol]
Metabolism of porphyrins (Canis familiaris)
Heme biosynthesis (Canis familiaris)
ABCG2 tetramer transports heme from cytosol to extracellular region (Canis familiaris)
Pi [cytosol]
Heme degradation (Canis familiaris)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Canis familiaris)
Pi [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Canis familiaris)
Pi [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Canis familiaris)
Transport of RCbl within the body (Canis familiaris)
ABCC1 transports cytosolic RCbl to extracellular region (Canis familiaris)
Pi [cytosol]
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Canis familiaris)
Pi [cytosol]
Uptake of dietary cobalamins into enterocytes (Canis familiaris)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Canis familiaris)
Pi [cytosol]
Metabolism of folate and pterines (Canis familiaris)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Canis familiaris)
Pi [cytosol]
FPGS-2 transforms THF to THFPG (Canis familiaris)
Pi [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Canis familiaris)
Pi [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Canis familiaris)
Pi [cytosol]
Nicotinate metabolism (Canis familiaris)
Nicotinamide salvage (Canis familiaris)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Canis familiaris)
Pi [cytosol]
Vitamin B1 (thiamin) metabolism (Canis familiaris)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Canis familiaris)
Pi [cytosol]
Vitamin B2 (riboflavin) metabolism (Canis familiaris)
2xTRAP hydrolyzes FMN to RIB (Canis familiaris)
Pi [cytosol]
Vitamin B5 (pantothenate) metabolism (Canis familiaris)
PANK4 hydrolyzes PPANT to pantetheine (Canis familiaris)
Pi [cytosol]
Pyrophosphate hydrolysis (Canis familiaris)
LHPP:Mg2+ dimer hydrolyses PPi (Canis familiaris)
Pi [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Canis familiaris)
Pi [cytosol]
Metabolism of RNA (Canis familiaris)
Deadenylation-dependent mRNA decay (Canis familiaris)
mRNA decay by 3' to 5' exoribonuclease (Canis familiaris)
NT5C3B hydrolyses 7MGP to 7MG (Canis familiaris)
Pi [cytosol]
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Asparagine N-linked glycosylation (Canis familiaris)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Canis familiaris)
Synthesis of substrates in N-glycan biosythesis (Canis familiaris)
Sialic acid metabolism (Canis familiaris)
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Canis familiaris)
Pi [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Canis familiaris)
Pi [cytosol]
Synthesis of dolichyl-phosphate (Canis familiaris)
DOLPP1 dephosphorylates DOLDP to DOLP (Canis familiaris)
Pi [cytosol]
MVD decarboxylates MVA5PP to IPPP (Canis familiaris)
Pi [cytosol]
Transport to the Golgi and subsequent modification (Canis familiaris)
ER to Golgi Anterograde Transport (Canis familiaris)
COPI-mediated anterograde transport (Canis familiaris)
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Canis familiaris)
Pi [cytosol]
COPII-mediated vesicle transport (Canis familiaris)
Loss of SAR1B GTPase (Canis familiaris)
Pi [cytosol]
NSF ATPase activity dissociates cis-SNARE (Canis familiaris)
Pi [cytosol]
PP6 dephosphorylates SEC24 (Canis familiaris)
Pi [cytosol]
Vesicle budding (Canis familiaris)
Pi [cytosol]
Carboxyterminal post-translational modifications of tubulin (Canis familiaris)
TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Canis familiaris)
Pi [cytosol]
TTLLs polyglutamylate tubulin (Canis familiaris)
Pi [cytosol]
Protein folding (Canis familiaris)
Chaperonin-mediated protein folding (Canis familiaris)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Canis familiaris)
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Canis familiaris)
Pi [cytosol]
Surfactant metabolism (Canis familiaris)
ABCA3 transports PC, PG from ER membrane to lamellar body (Canis familiaris)
Pi [cytosol]
SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Canis familiaris)
Pi [cytosol]
Translation (Canis familiaris)
Eukaryotic Translation Initiation (Canis familiaris)
Cap-dependent Translation Initiation (Canis familiaris)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Canis familiaris)
Cap-bound mRNA is activated by helicases (Canis familiaris)
Pi [cytosol]
GTP hydrolysis and joining of the 60S ribosomal subunit (Canis familiaris)
eIF2:GTP is hydrolyzed, eIFs are released (Canis familiaris)
Pi [cytosol]
eIF5B:GTP is hydrolyzed and released (Canis familiaris)
Pi [cytosol]
Ribosomal scanning and start codon recognition (Canis familiaris)
Ribosomal scanning (Canis familiaris)
Pi [cytosol]
tRNA Aminoacylation (Canis familiaris)
Cytosolic tRNA aminoacylation (Canis familiaris)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Canis familiaris)
Pi [cytosol]
Muscle contraction (Canis familiaris)
Cardiac conduction (Canis familiaris)
Ion homeostasis (Canis familiaris)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Canis familiaris)
Pi [cytosol]
Smooth Muscle Contraction (Canis familiaris)
ATP Hydrolysis By Myosin (Canis familiaris)
Pi [cytosol]
Striated Muscle Contraction (Canis familiaris)
ATP Hydrolysis By Myosin (Canis familiaris)
Pi [cytosol]
Neuronal System (Canis familiaris)
Transmission across Chemical Synapses (Canis familiaris)
Neurotransmitter receptors and postsynaptic signal transmission (Canis familiaris)
GABA receptor activation (Canis familiaris)
GABA B receptor activation (Canis familiaris)
Activation of GABAB receptors (Canis familiaris)
Adenylate cyclase inhibitory pathway (Canis familiaris)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Canis familiaris)
Pi [cytosol]
Adenylate cyclase increases the GTPase activity of Gi alpha (Canis familiaris)
Pi [cytosol]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Canis familiaris)
Trafficking of AMPA receptors (Canis familiaris)
Trafficking of GluR1-containing AMPA receptors (Canis familiaris)
Pi [cytosol]
Trafficking of GluR2-containing AMPA receptors (Canis familiaris)
Endocytosis of Ca impermeable AMPA receptors (Canis familiaris)
Pi [cytosol]
Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Canis familiaris)
Pi [cytosol]
Trafficking of GluR2-containing AMPA receptors to synapse (Canis familiaris)
Pi [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Canis familiaris)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Canis familiaris)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Canis familiaris)
Pi [cytosol]
Organelle biogenesis and maintenance (Canis familiaris)
Cilium Assembly (Canis familiaris)
Cargo trafficking to the periciliary membrane (Canis familiaris)
VxPx cargo-targeting to cilium (Canis familiaris)
ASAP1 stimulates GTPase activity of ARF4 (Canis familiaris)
Pi [cytosol]
Programmed Cell Death (Canis familiaris)
Apoptosis (Canis familiaris)
Intrinsic Pathway for Apoptosis (Canis familiaris)
Activation of BH3-only proteins (Canis familiaris)
Activation of BAD and translocation to mitochondria (Canis familiaris)
Activation of BAD by calcineurin (Canis familiaris)
Pi [cytosol]
Sensory Perception (Canis familiaris)
Visual phototransduction (Canis familiaris)
The canonical retinoid cycle in rods (twilight vision) (Canis familiaris)
ABCA4 mediates atRAL transport (Canis familiaris)
Pi [cytosol]
The phototransduction cascade (Canis familiaris)
Inactivation, recovery and regulation of the phototransduction cascade (Canis familiaris)
GNAT1-GTP hydrolyses its bound GTP to GDP (Canis familiaris)
Pi [cytosol]
PP2A dephosphorylates p-RHO to RHO (Canis familiaris)
Pi [cytosol]
Signal Transduction (Canis familiaris)
Integrin signaling (Canis familiaris)
Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
Pi [cytosol]
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PTEN dephosphorylates PIP3 (Canis familiaris)
Pi [cytosol]
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF-independent MAPK1/3 activation (Canis familiaris)
Cytosolic DUSPs dephosphorylate MAPKs (Canis familiaris)
Pi [cytosol]
RAF/MAP kinase cascade (Canis familiaris)
Negative regulation of MAPK pathway (Canis familiaris)
Cytosolic DUSPs dephosphorylate MAPKs (Canis familiaris)
Pi [cytosol]
PP2A dephosphorylates RAF1 (Canis familiaris)
Pi [cytosol]
PP5 dephosphorylates RAF1 S338 (Canis familiaris)
Pi [cytosol]
PTPN3 dephosphorylates MAPK12 (Canis familiaris)
Pi [cytosol]
MTOR signalling (Canis familiaris)
Energy dependent regulation of mTOR by LKB1-AMPK (Canis familiaris)
AMPK is dephosphorylated (Canis familiaris)
Pi [cytosol]
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Canis familiaris)
Pi [cytosol]
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (i) signalling events (Canis familiaris)
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Canis familiaris)
Pi [cytosol]
Opioid Signalling (Canis familiaris)
DARPP-32 events (Canis familiaris)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Canis familiaris)
Pi [cytosol]
G-protein mediated events (Canis familiaris)
Adenylate cyclase activating pathway (Canis familiaris)
Adenylaye cyclase increases the GTPase activity of G alpha-olf (Canis familiaris)
Pi [cytosol]
Adenylate cyclase inhibitory pathway (Canis familiaris)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Canis familiaris)
Pi [cytosol]
Adenylate cyclase increases the GTPase activity of Gi alpha (Canis familiaris)
Pi [cytosol]
PLC beta mediated events (Canis familiaris)
Inactivation of PLC beta (Canis familiaris)
Pi [cytosol]
G alpha (q) signalling events (Canis familiaris)
G alpha (q) in G (q):RGS complex is inactivated (Canis familiaris)
Pi [cytosol]
G alpha (z) signalling events (Canis familiaris)
G alpha (z) in G alpha (z):RGS complex is inactivated (Canis familiaris)
Pi [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Canis familiaris)
Signaling by PTK6 (Canis familiaris)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Canis familiaris)
ARHGAP35 stimulates RHOA GTPase activity (Canis familiaris)
Pi [cytosol]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ALK (Canis familiaris)
MDK and PTN in ALK signaling (Canis familiaris)
PTPRZ dephosphorylates ligand-bound ALK dimers (Canis familiaris)
Pi [cytosol]
PTPN6 dephosphorylates JAK3 (Canis familiaris)
Pi [cytosol]
Signaling by EGFR (Canis familiaris)
EGFR downregulation (Canis familiaris)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Canis familiaris)
Pi [cytosol]
PTPN3 dephosphorylates EPS15 (Canis familiaris)
Pi [cytosol]
GAB1 signalosome (Canis familiaris)
Dephosphorylation of Gab1 by SHP2 (Canis familiaris)
Pi [cytosol]
Dephosphorylation of PAG by SHP2 (Canis familiaris)
Pi [cytosol]
SHP2 dephosphorylates Tyr 992 on EGFR (Canis familiaris)
Pi [cytosol]
Sustained activation of SRC kinase by SHP2 (Canis familiaris)
Pi [cytosol]
Signaling by ERBB2 (Canis familiaris)
Downregulation of ERBB2 signaling (Canis familiaris)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Canis familiaris)
Pi [cytosol]
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Canis familiaris)
Pi [cytosol]
Signaling by FGFR (Canis familiaris)
Signaling by FGFR1 (Canis familiaris)
Negative regulation of FGFR1 signaling (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
PPA2A dephosphorylates SPRY2 (Canis familiaris)
Pi [cytosol]
Signaling by FGFR2 (Canis familiaris)
Negative regulation of FGFR2 signaling (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
PPA2A dephosphorylates SPRY2 (Canis familiaris)
Pi [cytosol]
Signaling by FGFR3 (Canis familiaris)
Negative regulation of FGFR3 signaling (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
PPA2A dephosphorylates SPRY2 (Canis familiaris)
Pi [cytosol]
Signaling by FGFR4 (Canis familiaris)
Negative regulation of FGFR4 signaling (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
PPA2A dephosphorylates SPRY2 (Canis familiaris)
Pi [cytosol]
Signaling by Insulin receptor (Canis familiaris)
Insulin receptor recycling (Canis familiaris)
Insulin receptor de-phosphorylation (Canis familiaris)
Pi [cytosol]
Signaling by MET (Canis familiaris)
Negative regulation of MET activity (Canis familiaris)
PTPN1 and PTPN2 dephosphorylate MET (Canis familiaris)
Pi [cytosol]
PTPRJ dephosphorylates MET (Canis familiaris)
Pi [cytosol]
Signaling by PDGF (Canis familiaris)
PTPN12 dephosphorylates PDGFRB at Y1021 (Canis familiaris)
Pi [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Miro GTPase Cycle (Canis familiaris)
RHOT1 GTPase cycle (Canis familiaris)
RHOT1 hydrolyzes GTP (Canis familiaris)
Pi [cytosol]
RHOBTB3 ATPase cycle (Canis familiaris)
RHOBTB3 hydrolyzes ATP (Canis familiaris)
Pi [cytosol]
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases Activate Formins (Canis familiaris)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Canis familiaris)
Pi [cytosol]
RHO GTPase cycle (Canis familiaris)
CDC42 GTPase cycle (Canis familiaris)
CDC42 GAPs stimulate CDC42 GTPase activity (Canis familiaris)
Pi [cytosol]
RAC1 GTPase cycle (Canis familiaris)
RAC1 GAPs stimulate RAC1 GTPase activity (Canis familiaris)
Pi [cytosol]
RAC2 GTPase cycle (Canis familiaris)
RAC2 GAPs stimulate RAC2 GTPase activity (Canis familiaris)
Pi [cytosol]
RAC3 GTPase cycle (Canis familiaris)
RAC3 GAPs stimulate RAC3 GTPase activity (Canis familiaris)
Pi [cytosol]
RHOA GTPase cycle (Canis familiaris)
RHOA GAPs stimulate RHOA GTPase activity (Canis familiaris)
Pi [cytosol]
RHOB GTPase cycle (Canis familiaris)
RHOB GAPs stimulate RHOB GTPase activity (Canis familiaris)
Pi [cytosol]
RHOC GTPase cycle (Canis familiaris)
RHOC GAPs stimulate RHOC GTPase activity (Canis familiaris)
Pi [cytosol]
RHOD GTPase cycle (Canis familiaris)
RHOD GAPs stimulate RHOD GTPase activity (Canis familiaris)
Pi [cytosol]
RHOF GTPase cycle (Canis familiaris)
RHOF GAPs stimulate RHOF GTPase activity (Canis familiaris)
Pi [cytosol]
RHOG GTPase cycle (Canis familiaris)
RHOG GAPs stimulate RHOG GTPase activity (Canis familiaris)
Pi [cytosol]
RHOJ GTPase cycle (Canis familiaris)
RHOJ GAPs stimulate RHOJ GTPase activity (Canis familiaris)
Pi [cytosol]
RHOQ GTPase cycle (Canis familiaris)
RHOQ GAPs stimulate RHOQ GTPase activity (Canis familiaris)
Pi [cytosol]
Signaling by TGFB family members (Canis familiaris)
Signaling by TGF-beta Receptor Complex (Canis familiaris)
TGF-beta receptor signaling activates SMADs (Canis familiaris)
Downregulation of TGF-beta receptor signaling (Canis familiaris)
MTMR4 dephosphorylates SMAD2/3 (Canis familiaris)
Pi [cytosol]
Signaling by WNT (Canis familiaris)
Beta-catenin independent WNT signaling (Canis familiaris)
Ca2+ pathway (Canis familiaris)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Canis familiaris)
Pi [cytosol]
Transport of small molecules (Canis familiaris)
ABC-family proteins mediated transport (Canis familiaris)
ABC transporters in lipid homeostasis (Canis familiaris)
ABCA12 transports lipids from cytosol to extracellular region (Canis familiaris)
Pi [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Canis familiaris)
Pi [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Canis familiaris)
Pi [cytosol]
ABCA7:Apo1A-mediated phospholipid efflux (Canis familiaris)
Pi [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Canis familiaris)
Pi [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Canis familiaris)
Pi [cytosol]
ABCG4 may mediate cholesterol efflux (Canis familiaris)
Pi [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Canis familiaris)
Pi [cytosol]
ABCA4 mediates atRAL transport (Canis familiaris)
Pi [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Canis familiaris)
Pi [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Canis familiaris)
Pi [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Canis familiaris)
Pi [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Canis familiaris)
Pi [cytosol]
HCO3- transport through ion channel (Canis familiaris)
Pi [cytosol]
Mitochondrial ABC transporters (Canis familiaris)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Canis familiaris)
Pi [cytosol]
The ABCC family mediates organic anion transport (Canis familiaris)
Pi [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Canis familiaris)
Pi [cytosol]
Ion channel transport (Canis familiaris)
Ion transport by P-type ATPases (Canis familiaris)
ATP12A:ATP4B exchanges K+ for H+ (Canis familiaris)
Pi [cytosol]
ATP13A1 transports Mn2+ from cytosol to ER lumen (Canis familiaris)
Pi [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Canis familiaris)
Pi [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Canis familiaris)
Pi [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Canis familiaris)
Pi [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Canis familiaris)
Pi [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Canis familiaris)
Pi [cytosol]
ATP7A transports cytosolic Cu2+ to extracellular region (Canis familiaris)
Pi [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Canis familiaris)
Pi [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Canis familiaris)
Pi [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Canis familiaris)
Pi [cytosol]
Stimuli-sensing channels (Canis familiaris)
SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Canis familiaris)
Pi [cytosol]
Iron uptake and transport (Canis familiaris)
ABCG2 tetramer transports heme from cytosol to extracellular region (Canis familiaris)
Pi [cytosol]
Transferrin endocytosis and recycling (Canis familiaris)
Acidification of Tf:TfR1 containing endosome (Canis familiaris)
Pi [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Canis familiaris)
Plasma lipoprotein assembly (Canis familiaris)
HDL assembly (Canis familiaris)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Canis familiaris)
Pi [cytosol]
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Canis familiaris)
Pi [cytosol]
Plasma lipoprotein remodeling (Canis familiaris)
HDL remodeling (Canis familiaris)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Canis familiaris)
Pi [cytosol]
SLC-mediated transmembrane transport (Canis familiaris)
Transport of inorganic cations/anions and amino acids/oligopeptides (Canis familiaris)
Organic anion transporters (Canis familiaris)
SLC25A10 mediates exchange of malate and phosphate (Canis familiaris)
Pi [cytosol]
Type I Na+-coupled phosphate co-transport (Canis familiaris)
Pi [cytosol]
Sodium-coupled phosphate cotransporters (Canis familiaris)
SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Canis familiaris)
Pi [cytosol]
Type II Na+/Pi cotransporters (Canis familiaris)
SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Canis familiaris)
Pi [cytosol]
SLC34A3 cotransports Pi, 2Na+ (Canis familiaris)
Pi [cytosol]
Vesicle-mediated transport (Canis familiaris)
Membrane Trafficking (Canis familiaris)
Clathrin-mediated endocytosis (Canis familiaris)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
Pi [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
Pi [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
Pi [cytosol]
ER to Golgi Anterograde Transport (Canis familiaris)
COPI-mediated anterograde transport (Canis familiaris)
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Canis familiaris)
Pi [cytosol]
COPII-mediated vesicle transport (Canis familiaris)
Loss of SAR1B GTPase (Canis familiaris)
Pi [cytosol]
NSF ATPase activity dissociates cis-SNARE (Canis familiaris)
Pi [cytosol]
PP6 dephosphorylates SEC24 (Canis familiaris)
Pi [cytosol]
Vesicle budding (Canis familiaris)
Pi [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Canis familiaris)
Golgi-to-ER retrograde transport (Canis familiaris)
COPI-dependent Golgi-to-ER retrograde traffic (Canis familiaris)
NSF ATPase activity dissociates cis-SNARE at the ER (Canis familiaris)
Pi [cytosol]
Rab regulation of trafficking (Canis familiaris)
TBC/RABGAPs (Canis familiaris)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Canis familiaris)
Pi [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Canis familiaris)
Pi [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Canis familiaris)
Pi [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Canis familiaris)
Pi [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Canis familiaris)
Pi [cytosol]
trans-Golgi Network Vesicle Budding (Canis familiaris)
Golgi Associated Vesicle Biogenesis (Canis familiaris)
trans-Golgi Network Coat Assembly (Canis familiaris)
Pi [cytosol]
trans-Golgi Network Derived Vesicle Uncoating (Canis familiaris)
Pi [cytosol]
trans-Golgi Network Vesicle Scission (Canis familiaris)
Pi [cytosol]
Lysosome Vesicle Biogenesis (Canis familiaris)
trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Canis familiaris)
Pi [cytosol]
trans-Golgi Network Lysosomal Vesicle Scission (Canis familiaris)
Pi [cytosol]
trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Canis familiaris)
Pi [cytosol]
Cell Cycle (Danio rerio)
Cell Cycle, Mitotic (Danio rerio)
M Phase (Danio rerio)
Mitotic Metaphase and Anaphase (Danio rerio)
Mitotic Anaphase (Danio rerio)
Nuclear Envelope (NE) Reassembly (Danio rerio)
Initiation of Nuclear Envelope (NE) Reformation (Danio rerio)
PP2A dephosphorylates BANF1 (Danio rerio)
Pi [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Danio rerio)
RAN stimulates fusion of nuclear envelope (NE) membranes (Danio rerio)
Pi [cytosol]
Cellular responses to stimuli (Danio rerio)
Cellular responses to mechanical stimuli (Danio rerio)
Response of endothelial cells to shear stress (Danio rerio)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Danio rerio)
PP2A dephosphorylates serine-127 of YAP1 (Danio rerio)
Pi [cytosol]
Cellular responses to stress (Danio rerio)
Cellular response to heat stress (Danio rerio)
Regulation of HSF1-mediated heat shock response (Danio rerio)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Danio rerio)
Pi [cytosol]
Cellular response to starvation (Danio rerio)
Amino acids regulate mTORC1 (Danio rerio)
RRAGA,B hydrolyzes GTP (Danio rerio)
Pi [cytosol]
RRAGC,D hydrolyzes GTP (Danio rerio)
Pi [cytosol]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Danio rerio)
ATP hydrolysis by HSP70 (Danio rerio)
Pi [cytosol]
Developmental Biology (Danio rerio)
Nervous system development (Danio rerio)
Axon guidance (Danio rerio)
EPH-Ephrin signaling (Danio rerio)
EPHB-mediated forward signaling (Danio rerio)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Danio rerio)
Pi [cytosol]
Semaphorin interactions (Danio rerio)
Sema4D in semaphorin signaling (Danio rerio)
Sema4D mediated inhibition of cell attachment and migration (Danio rerio)
Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Danio rerio)
Pi [cytosol]
Inactivation of Rho-GTP by p190RhoGAP (Danio rerio)
Pi [cytosol]
Drug ADME (Danio rerio)
Aspirin ADME (Danio rerio)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Danio rerio)
Pi [cytosol]
Azathioprine ADME (Danio rerio)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Danio rerio)
Pi [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Danio rerio)
Pi [cytosol]
Paracetamol ADME (Danio rerio)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Danio rerio)
Pi [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Danio rerio)
Pi [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Danio rerio)
Pi [cytosol]
Gene expression (Transcription) (Danio rerio)
RNA Polymerase II Transcription (Danio rerio)
Generic Transcription Pathway (Danio rerio)
Transcriptional Regulation by TP53 (Danio rerio)
TP53 Regulates Metabolic Genes (Danio rerio)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Danio rerio)
Pi [cytosol]
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Danio rerio)
Pi [cytosol]
Hemostasis (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
Response to elevated platelet cytosolic Ca2+ (Danio rerio)
Platelet degranulation (Danio rerio)
ABCC4 accumulation of dense granule contents (Danio rerio)
Pi [cytosol]
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
MHC class II antigen presentation (Danio rerio)
Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Danio rerio)
Pi [cytosol]
Translocation of TGN-lysosome vesicle to lysosome (Danio rerio)
Pi [cytosol]
TCR signaling (Danio rerio)
Downstream TCR signaling (Danio rerio)
PTEN dephosphorylates PIP3 (Danio rerio)
Pi [cytosol]
Cytokine Signaling in Immune system (Danio rerio)
Growth hormone receptor signaling (Danio rerio)
PTP1B dephosphorylates GHR (Danio rerio)
Pi [cytosol]
Innate Immune System (Danio rerio)
Antimicrobial peptides (Danio rerio)
Ion influx/efflux at host-pathogen interface (Danio rerio)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Danio rerio)
Pi [cytosol]
Metabolism (Danio rerio)
Aerobic respiration and respiratory electron transport (Danio rerio)
Pyruvate metabolism (Danio rerio)
Regulation of pyruvate metabolism (Danio rerio)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Danio rerio)
Pi [cytosol]
Biological oxidations (Danio rerio)
Phase II - Conjugation of compounds (Danio rerio)
Glutathione conjugation (Danio rerio)
Glutathione synthesis and recycling (Danio rerio)
GSS:Mg2+ dimer synthesizes GSH (Danio rerio)
Pi [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Danio rerio)
Pi [cytosol]
Methylation (Danio rerio)
MAT1A multimers transfer Ado from ATP to L-Met (Danio rerio)
Pi [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Danio rerio)
Pi [cytosol]
Inositol phosphate metabolism (Danio rerio)
Synthesis of IP2, IP, and Ins in the cytosol (Danio rerio)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Danio rerio)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Danio rerio)
Pi [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Danio rerio)
Pi [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)
Pi [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)
Pi [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)
Pi [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Danio rerio)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Danio rerio)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Danio rerio)
Pi [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Danio rerio)
Pi [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Danio rerio)
Pi [cytosol]
Synthesis of pyrophosphates in the cytosol (Danio rerio)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Danio rerio)
Pi [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Danio rerio)
Pi [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Danio rerio)
Pi [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Danio rerio)
Pi [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Danio rerio)
Pi [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Danio rerio)
Pi [cytosol]
Metabolism of amino acids and derivatives (Danio rerio)
Glutamate and glutamine metabolism (Danio rerio)
N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Danio rerio)
Pi [cytosol]
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Danio rerio)
Pi [cytosol]
Selenoamino acid metabolism (Danio rerio)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Danio rerio)
SeMet is converted to AdoSeMet by MAT (Danio rerio)
Pi [cytosol]
Selenocysteine synthesis (Danio rerio)
SEPHS2 phosphorylates H2Se to form SELP (Danio rerio)
Pi [cytosol]
Serine metabolism (Danio rerio)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Danio rerio)
Pi [cytosol]
Sulfur amino acid metabolism (Danio rerio)
MAT1A multimers transfer Ado from ATP to L-Met (Danio rerio)
Pi [cytosol]
Methionine salvage pathway (Danio rerio)
Acireductone is created (Danio rerio)
Pi [cytosol]
MTA is cleaved and phosphorylated (Danio rerio)
Pi [cytosol]
Metabolism of carbohydrates and carbohydrate derivatives (Danio rerio)
Glucose metabolism (Danio rerio)
Gluconeogenesis (Danio rerio)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Danio rerio)
Pi [cytosol]
GAPDH tetramers reduce 1,3BPG to GA3P (Danio rerio)
Pi [cytosol]
SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Danio rerio)
Pi [cytosol]
SLC7A4 exchanges G6P for Pi across the ER membrane (Danio rerio)
Pi [cytosol]
Glycolysis (Danio rerio)
GADPH tetramer dehydrogenates GA3P (Danio rerio)
Pi [cytosol]
Glycogen metabolism (Danio rerio)
Glycogen synthesis (Danio rerio)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Danio rerio)
Pi [cytosol]
Pentose phosphate pathway (Danio rerio)
5-Phosphoribose 1-diphosphate biosynthesis (Danio rerio)
PRPS dimers pyrophosphorylate R5P using ATP (Danio rerio)
Pi [cytosol]
PRPS1 dimer pyrophosphorylates R5P using dATP (Danio rerio)
Pi [cytosol]
Metabolism of lipids (Danio rerio)
Fatty acid metabolism (Danio rerio)
Fatty acyl-CoA biosynthesis (Danio rerio)
ACLY tetramer transforms CIT to Ac-CoA (Danio rerio)
Pi [cytosol]
Metabolism of steroids (Danio rerio)
Cholesterol biosynthesis (Danio rerio)
MVD decarboxylates MVA5PP to IPPP (Danio rerio)
Pi [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Danio rerio)
Pi [cytosol]
Phospholipid metabolism (Danio rerio)
Glycerophospholipid biosynthesis (Danio rerio)
PGP:Mg2+ dimer hydrolyses G3P to glycerol (Danio rerio)
Pi [cytosol]
Synthesis of PC (Danio rerio)
PA is dephosphorylated to DAG by LPIN (Danio rerio)
Pi [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Danio rerio)
Pi [cytosol]
Synthesis of PE (Danio rerio)
PA is dephosphorylated to DAG by LPIN (Danio rerio)
Pi [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Danio rerio)
Pi [cytosol]
PI Metabolism (Danio rerio)
Synthesis of PIPs at the ER membrane (Danio rerio)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Danio rerio)
Pi [cytosol]
Synthesis of PIPs at the Golgi membrane (Danio rerio)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Danio rerio)
Pi [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Danio rerio)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Danio rerio)
Pi [cytosol]
Synthesis of PIPs at the early endosome membrane (Danio rerio)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Danio rerio)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Danio rerio)
Pi [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Danio rerio)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Danio rerio)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Danio rerio)
Pi [cytosol]
Synthesis of PIPs at the late endosome membrane (Danio rerio)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Danio rerio)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Danio rerio)
Pi [cytosol]
Synthesis of PIPs at the plasma membrane (Danio rerio)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Danio rerio)
Pi [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Danio rerio)
Pi [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Danio rerio)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Danio rerio)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Danio rerio)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Danio rerio)
Pi [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Danio rerio)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Danio rerio)
Pi [cytosol]
Sphingolipid metabolism (Danio rerio)
Sphingolipid catabolism (Danio rerio)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Danio rerio)
Pi [cytosol]
Sphingolipid de novo biosynthesis (Danio rerio)
PPM1L dephosphorylates multiphospho-CERT1-2 (Danio rerio)
Pi [cytosol]
Metabolism of nucleotides (Danio rerio)
Interconversion of nucleotide di- and triphosphates (Danio rerio)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Danio rerio)
Pi [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Danio rerio)
Pi [cytosol]
Nucleotide biosynthesis (Danio rerio)
Purine ribonucleoside monophosphate biosynthesis (Danio rerio)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Danio rerio)
Pi [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Danio rerio)
Pi [cytosol]
FGAM + ATP => AIR + ADP + Pi (Danio rerio)
Pi [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Danio rerio)
Pi [cytosol]
Nucleotide catabolism (Danio rerio)
Purine catabolism (Danio rerio)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Danio rerio)
Pi [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Danio rerio)
Pi [cytosol]
PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Danio rerio)
Pi [cytosol]
PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Danio rerio)
Pi [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Danio rerio)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Danio rerio)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Danio rerio)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Danio rerio)
Pi [cytosol]
Pyrimidine catabolism (Danio rerio)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Danio rerio)
Pi [cytosol]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Danio rerio)
Pi [cytosol]
(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Danio rerio)
Pi [cytosol]
Nucleotide salvage (Danio rerio)
Purine salvage (Danio rerio)
PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Danio rerio)
Pi [cytosol]
PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Danio rerio)
Pi [cytosol]
Pyrimidine salvage (Danio rerio)
HDHD1:Mg2+ dephosphorylates PURIDP (Danio rerio)
Pi [cytosol]
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Danio rerio)
Pi [cytosol]
Metabolism of porphyrins (Danio rerio)
Heme degradation (Danio rerio)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Danio rerio)
Pi [cytosol]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Metabolism of folate and pterines (Danio rerio)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Danio rerio)
Pi [cytosol]
FPGS-2 transforms THF to THFPG (Danio rerio)
Pi [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Danio rerio)
Pi [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Danio rerio)
Pi [cytosol]
Nicotinate metabolism (Danio rerio)
Nicotinamide salvage (Danio rerio)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Danio rerio)
Pi [cytosol]
Vitamin B2 (riboflavin) metabolism (Danio rerio)
2xTRAP hydrolyzes FMN to RIB (Danio rerio)
Pi [cytosol]
Pyrophosphate hydrolysis (Danio rerio)
LHPP:Mg2+ dimer hydrolyses PPi (Danio rerio)
Pi [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Danio rerio)
Pi [cytosol]
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Asparagine N-linked glycosylation (Danio rerio)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Danio rerio)
Synthesis of substrates in N-glycan biosythesis (Danio rerio)
Sialic acid metabolism (Danio rerio)
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Danio rerio)
Pi [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Danio rerio)
Pi [cytosol]
Synthesis of dolichyl-phosphate (Danio rerio)
DOLPP1 dephosphorylates DOLDP to DOLP (Danio rerio)
Pi [cytosol]
MVD decarboxylates MVA5PP to IPPP (Danio rerio)
Pi [cytosol]
Transport to the Golgi and subsequent modification (Danio rerio)
ER to Golgi Anterograde Transport (Danio rerio)
COPII-mediated vesicle transport (Danio rerio)
NSF ATPase activity dissociates cis-SNARE (Danio rerio)
Pi [cytosol]
Protein folding (Danio rerio)
Chaperonin-mediated protein folding (Danio rerio)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Danio rerio)
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Danio rerio)
Pi [cytosol]
Surfactant metabolism (Danio rerio)
SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Danio rerio)
Pi [cytosol]
Translation (Danio rerio)
Eukaryotic Translation Initiation (Danio rerio)
Cap-dependent Translation Initiation (Danio rerio)
Ribosomal scanning and start codon recognition (Danio rerio)
Ribosomal scanning (Danio rerio)
Pi [cytosol]
tRNA Aminoacylation (Danio rerio)
Cytosolic tRNA aminoacylation (Danio rerio)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Danio rerio)
Pi [cytosol]
Muscle contraction (Danio rerio)
Cardiac conduction (Danio rerio)
Ion homeostasis (Danio rerio)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Danio rerio)
Pi [cytosol]
Neuronal System (Danio rerio)
Transmission across Chemical Synapses (Danio rerio)
Neurotransmitter receptors and postsynaptic signal transmission (Danio rerio)
GABA receptor activation (Danio rerio)
GABA B receptor activation (Danio rerio)
Activation of GABAB receptors (Danio rerio)
Adenylate cyclase inhibitory pathway (Danio rerio)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Danio rerio)
Pi [cytosol]
Adenylate cyclase increases the GTPase activity of Gi alpha (Danio rerio)
Pi [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Danio rerio)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Danio rerio)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Danio rerio)
Pi [cytosol]
Organelle biogenesis and maintenance (Danio rerio)
Cilium Assembly (Danio rerio)
Cargo trafficking to the periciliary membrane (Danio rerio)
VxPx cargo-targeting to cilium (Danio rerio)
ASAP1 stimulates GTPase activity of ARF4 (Danio rerio)
Pi [cytosol]
Signal Transduction (Danio rerio)
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
Negative regulation of the PI3K/AKT network (Danio rerio)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Danio rerio)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Danio rerio)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Danio rerio)
Pi [cytosol]
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF-independent MAPK1/3 activation (Danio rerio)
Cytosolic DUSPs dephosphorylate MAPKs (Danio rerio)
Pi [cytosol]
RAF/MAP kinase cascade (Danio rerio)
Negative regulation of MAPK pathway (Danio rerio)
Cytosolic DUSPs dephosphorylate MAPKs (Danio rerio)
Pi [cytosol]
RAF activation (Danio rerio)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Danio rerio)
Pi [cytosol]
MTOR signalling (Danio rerio)
Energy dependent regulation of mTOR by LKB1-AMPK (Danio rerio)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Danio rerio)
Pi [cytosol]
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (i) signalling events (Danio rerio)
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Danio rerio)
Pi [cytosol]
Opioid Signalling (Danio rerio)
G-protein mediated events (Danio rerio)
Adenylate cyclase activating pathway (Danio rerio)
Adenylaye cyclase increases the GTPase activity of G alpha-olf (Danio rerio)
Pi [cytosol]
Adenylate cyclase inhibitory pathway (Danio rerio)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Danio rerio)
Pi [cytosol]
Adenylate cyclase increases the GTPase activity of Gi alpha (Danio rerio)
Pi [cytosol]
G alpha (q) signalling events (Danio rerio)
G alpha (q) in G (q):RGS complex is inactivated (Danio rerio)
Pi [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Danio rerio)
Signaling by PTK6 (Danio rerio)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Danio rerio)
ARHGAP35 stimulates RHOA GTPase activity (Danio rerio)
Pi [cytosol]
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by ERBB2 (Danio rerio)
Downregulation of ERBB2 signaling (Danio rerio)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Danio rerio)
Pi [cytosol]
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Danio rerio)
Pi [cytosol]
Signaling by FGFR (Danio rerio)
Signaling by FGFR1 (Danio rerio)
Negative regulation of FGFR1 signaling (Danio rerio)
Spry regulation of FGF signaling (Danio rerio)
PPA2A dephosphorylates SPRY2 (Danio rerio)
Pi [cytosol]
Signaling by FGFR2 (Danio rerio)
Negative regulation of FGFR2 signaling (Danio rerio)
Spry regulation of FGF signaling (Danio rerio)
PPA2A dephosphorylates SPRY2 (Danio rerio)
Pi [cytosol]
Signaling by FGFR3 (Danio rerio)
Negative regulation of FGFR3 signaling (Danio rerio)
Spry regulation of FGF signaling (Danio rerio)
PPA2A dephosphorylates SPRY2 (Danio rerio)
Pi [cytosol]
Signaling by FGFR4 (Danio rerio)
Negative regulation of FGFR4 signaling (Danio rerio)
Spry regulation of FGF signaling (Danio rerio)
PPA2A dephosphorylates SPRY2 (Danio rerio)
Pi [cytosol]
Signaling by PDGF (Danio rerio)
PTPN12 dephosphorylates PDGFRB at Y1021 (Danio rerio)
Pi [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
Miro GTPase Cycle (Danio rerio)
RHOT1 GTPase cycle (Danio rerio)
RHOT1 hydrolyzes GTP (Danio rerio)
Pi [cytosol]
RHOT2 GTPase cycle (Danio rerio)
RHOT2 hydrolyzes GTP (Danio rerio)
Pi [cytosol]
Signaling by Rho GTPases (Danio rerio)
RHO GTPase Effectors (Danio rerio)
RHO GTPases Activate Formins (Danio rerio)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Danio rerio)
Pi [cytosol]
RHO GTPase cycle (Danio rerio)
CDC42 GTPase cycle (Danio rerio)
CDC42 GAPs stimulate CDC42 GTPase activity (Danio rerio)
Pi [cytosol]
RAC1 GTPase cycle (Danio rerio)
RAC1 GAPs stimulate RAC1 GTPase activity (Danio rerio)
Pi [cytosol]
RAC2 GTPase cycle (Danio rerio)
RAC2 GAPs stimulate RAC2 GTPase activity (Danio rerio)
Pi [cytosol]
RAC3 GTPase cycle (Danio rerio)
RAC3 GAPs stimulate RAC3 GTPase activity (Danio rerio)
Pi [cytosol]
RHOA GTPase cycle (Danio rerio)
RHOA GAPs stimulate RHOA GTPase activity (Danio rerio)
Pi [cytosol]
RHOD GTPase cycle (Danio rerio)
RHOD GAPs stimulate RHOD GTPase activity (Danio rerio)
Pi [cytosol]
RHOF GTPase cycle (Danio rerio)
RHOF GAPs stimulate RHOF GTPase activity (Danio rerio)
Pi [cytosol]
RHOG GTPase cycle (Danio rerio)
RHOG GAPs stimulate RHOG GTPase activity (Danio rerio)
Pi [cytosol]
RHOQ GTPase cycle (Danio rerio)
RHOQ GAPs stimulate RHOQ GTPase activity (Danio rerio)
Pi [cytosol]
Transport of small molecules (Danio rerio)
ABC-family proteins mediated transport (Danio rerio)
ABC transporters in lipid homeostasis (Danio rerio)
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Danio rerio)
Pi [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Danio rerio)
Pi [cytosol]
ABCG4 may mediate cholesterol efflux (Danio rerio)
Pi [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Danio rerio)
Pi [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Danio rerio)
Pi [cytosol]
HCO3- transport through ion channel (Danio rerio)
Pi [cytosol]
The ABCC family mediates organic anion transport (Danio rerio)
Pi [cytosol]
Ion channel transport (Danio rerio)
Ion transport by P-type ATPases (Danio rerio)
ATP13A2 transports cations from cytosol to lysosomal lumen (Danio rerio)
Pi [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Danio rerio)
Pi [cytosol]
ATP7A transports cytosolic Cu2+ to extracellular region (Danio rerio)
Pi [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Danio rerio)
Pi [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Danio rerio)
Pi [cytosol]
Iron uptake and transport (Danio rerio)
Transferrin endocytosis and recycling (Danio rerio)
Acidification of Tf:TfR1 containing endosome (Danio rerio)
Pi [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Danio rerio)
Plasma lipoprotein assembly (Danio rerio)
HDL assembly (Danio rerio)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Danio rerio)
Pi [cytosol]
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Danio rerio)
Pi [cytosol]
Plasma lipoprotein remodeling (Danio rerio)
HDL remodeling (Danio rerio)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Danio rerio)
Pi [cytosol]
SLC-mediated transmembrane transport (Danio rerio)
Transport of inorganic cations/anions and amino acids/oligopeptides (Danio rerio)
Organic anion transporters (Danio rerio)
SLC25A10 mediates exchange of malate and phosphate (Danio rerio)
Pi [cytosol]
Sodium-coupled phosphate cotransporters (Danio rerio)
SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Danio rerio)
Pi [cytosol]
Type II Na+/Pi cotransporters (Danio rerio)
SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Danio rerio)
Pi [cytosol]
Vesicle-mediated transport (Danio rerio)
Membrane Trafficking (Danio rerio)
ER to Golgi Anterograde Transport (Danio rerio)
COPII-mediated vesicle transport (Danio rerio)
NSF ATPase activity dissociates cis-SNARE (Danio rerio)
Pi [cytosol]
Rab regulation of trafficking (Danio rerio)
TBC/RABGAPs (Danio rerio)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Danio rerio)
Pi [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Danio rerio)
Pi [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Danio rerio)
Pi [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Danio rerio)
Pi [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Danio rerio)
Pi [cytosol]
trans-Golgi Network Vesicle Budding (Danio rerio)
Lysosome Vesicle Biogenesis (Danio rerio)
trans-Golgi Network Lysosomal Vesicle Scission (Danio rerio)
Pi [cytosol]
Autophagy (Dictyostelium discoideum)
Macroautophagy (Dictyostelium discoideum)
ULK1 is dephosphorylated (Dictyostelium discoideum)
Pi [cytosol]
Cell Cycle (Dictyostelium discoideum)
Cell Cycle, Mitotic (Dictyostelium discoideum)
M Phase (Dictyostelium discoideum)
Mitotic Metaphase and Anaphase (Dictyostelium discoideum)
Mitotic Anaphase (Dictyostelium discoideum)
Nuclear Envelope (NE) Reassembly (Dictyostelium discoideum)
Sealing of the nuclear envelope (NE) by ESCRT-III (Dictyostelium discoideum)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Dictyostelium discoideum)
Pi [cytosol]
Mitotic Prometaphase (Dictyostelium discoideum)
Condensation of Prometaphase Chromosomes (Dictyostelium discoideum)
Dephosphorylation of CK2-modified condensin I (Dictyostelium discoideum)
Pi [cytosol]
Resolution of Sister Chromatid Cohesion (Dictyostelium discoideum)
PPP1CC dephosphorylates PLK1 (Dictyostelium discoideum)
Pi [cytosol]
Cellular responses to stimuli (Dictyostelium discoideum)
Cellular responses to stress (Dictyostelium discoideum)
Cellular response to heat stress (Dictyostelium discoideum)
Regulation of HSF1-mediated heat shock response (Dictyostelium discoideum)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Dictyostelium discoideum)
Pi [cytosol]
Cellular response to starvation (Dictyostelium discoideum)
Amino acids regulate mTORC1 (Dictyostelium discoideum)
RRAGA,B hydrolyzes GTP (Dictyostelium discoideum)
Pi [cytosol]
RRAGC,D hydrolyzes GTP (Dictyostelium discoideum)
Pi [cytosol]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Dictyostelium discoideum)
ATP hydrolysis by HSP70 (Dictyostelium discoideum)
Pi [cytosol]
Drug ADME (Dictyostelium discoideum)
Aspirin ADME (Dictyostelium discoideum)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Dictyostelium discoideum)
Pi [cytosol]
Azathioprine ADME (Dictyostelium discoideum)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Dictyostelium discoideum)
Pi [cytosol]
Paracetamol ADME (Dictyostelium discoideum)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Dictyostelium discoideum)
Pi [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Dictyostelium discoideum)
Pi [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Dictyostelium discoideum)
Pi [cytosol]
Prednisone ADME (Dictyostelium discoideum)
ABCB1 transports PREDN,PREDL out of hepatic cells (Dictyostelium discoideum)
Pi [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Dictyostelium discoideum)
Pi [cytosol]
ABCB1 transports xenobiotics out of the cell (Dictyostelium discoideum)
Pi [cytosol]
Gene expression (Transcription) (Dictyostelium discoideum)
RNA Polymerase II Transcription (Dictyostelium discoideum)
Generic Transcription Pathway (Dictyostelium discoideum)
Transcriptional Regulation by TP53 (Dictyostelium discoideum)
TP53 Regulates Metabolic Genes (Dictyostelium discoideum)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Dictyostelium discoideum)
Pi [cytosol]
Hemostasis (Dictyostelium discoideum)
Platelet activation, signaling and aggregation (Dictyostelium discoideum)
Response to elevated platelet cytosolic Ca2+ (Dictyostelium discoideum)
Platelet degranulation (Dictyostelium discoideum)
ABCC4 accumulation of dense granule contents (Dictyostelium discoideum)
Pi [cytosol]
Immune System (Dictyostelium discoideum)
Adaptive Immune System (Dictyostelium discoideum)
Regulation of T cell activation by CD28 family (Dictyostelium discoideum)
Co-inhibition by CTLA4 (Dictyostelium discoideum)
Dephosphorylation of AKT by PP2A (Dictyostelium discoideum)
Pi [cytosol]
TCR signaling (Dictyostelium discoideum)
Downstream TCR signaling (Dictyostelium discoideum)
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
Pi [cytosol]
Innate Immune System (Dictyostelium discoideum)
Fcgamma receptor (FCGR) dependent phagocytosis (Dictyostelium discoideum)
Role of phospholipids in phagocytosis (Dictyostelium discoideum)
Conversion of PA into DAG by PAP-1 (Dictyostelium discoideum)
Pi [cytosol]
Metabolism (Dictyostelium discoideum)
Biological oxidations (Dictyostelium discoideum)
Phase II - Conjugation of compounds (Dictyostelium discoideum)
Cytosolic sulfonation of small molecules (Dictyostelium discoideum)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Dictyostelium discoideum)
Pi [cytosol]
Glutathione conjugation (Dictyostelium discoideum)
Glutathione synthesis and recycling (Dictyostelium discoideum)
GSS:Mg2+ dimer synthesizes GSH (Dictyostelium discoideum)
Pi [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Dictyostelium discoideum)
Pi [cytosol]
Methylation (Dictyostelium discoideum)
MAT1A multimers transfer Ado from ATP to L-Met (Dictyostelium discoideum)
Pi [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Dictyostelium discoideum)
Pi [cytosol]
Inositol phosphate metabolism (Dictyostelium discoideum)
Synthesis of IP2, IP, and Ins in the cytosol (Dictyostelium discoideum)
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Dictyostelium discoideum)
Pi [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Dictyostelium discoideum)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Dictyostelium discoideum)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Dictyostelium discoideum)
Pi [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)
Pi [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)
Pi [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)
Pi [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Dictyostelium discoideum)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Dictyostelium discoideum)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Dictyostelium discoideum)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Dictyostelium discoideum)
Pi [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Dictyostelium discoideum)
Pi [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Dictyostelium discoideum)
Pi [cytosol]
Synthesis of pyrophosphates in the cytosol (Dictyostelium discoideum)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Dictyostelium discoideum)
Pi [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Dictyostelium discoideum)
Pi [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Dictyostelium discoideum)
Pi [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Dictyostelium discoideum)
Pi [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)
Pi [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Dictyostelium discoideum)
Pi [cytosol]
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Selenoamino acid metabolism (Dictyostelium discoideum)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Dictyostelium discoideum)
SeMet is converted to AdoSeMet by MAT (Dictyostelium discoideum)
Pi [cytosol]
Selenocysteine synthesis (Dictyostelium discoideum)
SEPHS2 phosphorylates H2Se to form SELP (Dictyostelium discoideum)
Pi [cytosol]
Serine metabolism (Dictyostelium discoideum)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Dictyostelium discoideum)
Pi [cytosol]
Sulfur amino acid metabolism (Dictyostelium discoideum)
MAT1A multimers transfer Ado from ATP to L-Met (Dictyostelium discoideum)
Pi [cytosol]
Methionine salvage pathway (Dictyostelium discoideum)
Acireductone is created (Dictyostelium discoideum)
Pi [cytosol]
Metabolism of carbohydrates and carbohydrate derivatives (Dictyostelium discoideum)
Glucose metabolism (Dictyostelium discoideum)
Gluconeogenesis (Dictyostelium discoideum)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Dictyostelium discoideum)
Pi [cytosol]
GAPDH tetramers reduce 1,3BPG to GA3P (Dictyostelium discoideum)
Pi [cytosol]
Glycolysis (Dictyostelium discoideum)
GADPH tetramer dehydrogenates GA3P (Dictyostelium discoideum)
Pi [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Dictyostelium discoideum)
PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (Dictyostelium discoideum)
Pi [cytosol]
Glycogen metabolism (Dictyostelium discoideum)
Glycogen breakdown (glycogenolysis) (Dictyostelium discoideum)
glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Dictyostelium discoideum)
Pi [cytosol]
poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Dictyostelium discoideum)
Pi [cytosol]
Pentose phosphate pathway (Dictyostelium discoideum)
5-Phosphoribose 1-diphosphate biosynthesis (Dictyostelium discoideum)
PRPS dimers pyrophosphorylate R5P using ATP (Dictyostelium discoideum)
Pi [cytosol]
PRPS1 dimer pyrophosphorylates R5P using dATP (Dictyostelium discoideum)
Pi [cytosol]
Metabolism of lipids (Dictyostelium discoideum)
Fatty acid metabolism (Dictyostelium discoideum)
Arachidonate metabolism (Dictyostelium discoideum)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Dictyostelium discoideum)
LTC4 is exported from the cytosol by ABCC1 (Dictyostelium discoideum)
Pi [cytosol]
Carnitine shuttle (Dictyostelium discoideum)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Dictyostelium discoideum)
Pi [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Dictyostelium discoideum)
Pi [cytosol]
Fatty acyl-CoA biosynthesis (Dictyostelium discoideum)
ACLY tetramer transforms CIT to Ac-CoA (Dictyostelium discoideum)
Pi [cytosol]
Formation of Malonyl-CoA from Acetyl-CoA (liver) (Dictyostelium discoideum)
Pi [cytosol]
Metabolism of steroids (Dictyostelium discoideum)
Bile acid and bile salt metabolism (Dictyostelium discoideum)
Recycling of bile acids and salts (Dictyostelium discoideum)
ABCB11 transports bile salts from cytosol to extracellular region (Dictyostelium discoideum)
Pi [cytosol]
ABCC3 transports bile salts from cytosol to extracellular region (Dictyostelium discoideum)
Pi [cytosol]
Synthesis of bile acids and bile salts (Dictyostelium discoideum)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Dictyostelium discoideum)
ABCB11 transports bile salts from cytosol to extracellular region (Dictyostelium discoideum)
Pi [cytosol]
Cholesterol biosynthesis (Dictyostelium discoideum)
MVD decarboxylates MVA5PP to IPPP (Dictyostelium discoideum)
Pi [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Dictyostelium discoideum)
Pi [cytosol]
Phospholipid metabolism (Dictyostelium discoideum)
Glycerophospholipid biosynthesis (Dictyostelium discoideum)
Synthesis of PC (Dictyostelium discoideum)
PA is dephosphorylated to DAG by LPIN (Dictyostelium discoideum)
Pi [cytosol]
Synthesis of PE (Dictyostelium discoideum)
PA is dephosphorylated to DAG by LPIN (Dictyostelium discoideum)
Pi [cytosol]
PI Metabolism (Dictyostelium discoideum)
Synthesis of PIPs at the ER membrane (Dictyostelium discoideum)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Dictyostelium discoideum)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Dictyostelium discoideum)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Dictyostelium discoideum)
Pi [cytosol]
Synthesis of PIPs at the Golgi membrane (Dictyostelium discoideum)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Dictyostelium discoideum)
Pi [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Dictyostelium discoideum)
Pi [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Dictyostelium discoideum)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Dictyostelium discoideum)
Pi [cytosol]
Synthesis of PIPs at the early endosome membrane (Dictyostelium discoideum)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Dictyostelium discoideum)
Pi [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Dictyostelium discoideum)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Dictyostelium discoideum)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Dictyostelium discoideum)
Pi [cytosol]
Synthesis of PIPs at the late endosome membrane (Dictyostelium discoideum)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Dictyostelium discoideum)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Dictyostelium discoideum)
Pi [cytosol]
Synthesis of PIPs at the plasma membrane (Dictyostelium discoideum)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Dictyostelium discoideum)
Pi [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Dictyostelium discoideum)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Dictyostelium discoideum)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Dictyostelium discoideum)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Dictyostelium discoideum)
Pi [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Dictyostelium discoideum)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Dictyostelium discoideum)
Pi [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Dictyostelium discoideum)
Pi [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Dictyostelium discoideum)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
Pi [cytosol]
Sphingolipid metabolism (Dictyostelium discoideum)
Sphingolipid catabolism (Dictyostelium discoideum)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Dictyostelium discoideum)
Pi [cytosol]
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Dictyostelium discoideum)
Pi [cytosol]
Sphingolipid de novo biosynthesis (Dictyostelium discoideum)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Dictyostelium discoideum)
Pi [cytosol]
Triglyceride metabolism (Dictyostelium discoideum)
Triglyceride biosynthesis (Dictyostelium discoideum)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Dictyostelium discoideum)
Pi [cytosol]
Metabolism of nucleotides (Dictyostelium discoideum)
Interconversion of nucleotide di- and triphosphates (Dictyostelium discoideum)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Dictyostelium discoideum)
Pi [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Dictyostelium discoideum)
Pi [cytosol]
Nucleotide biosynthesis (Dictyostelium discoideum)
Purine ribonucleoside monophosphate biosynthesis (Dictyostelium discoideum)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Dictyostelium discoideum)
Pi [cytosol]
FGAM + ATP => AIR + ADP + Pi (Dictyostelium discoideum)
Pi [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Dictyostelium discoideum)
Pi [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Dictyostelium discoideum)
Pi [cytosol]
Pyrimidine biosynthesis (Dictyostelium discoideum)
CAD hexamer transforms CAP to N-carb-L-Asp (Dictyostelium discoideum)
Pi [cytosol]
CAD hexamer transforms L-Gln to CAP (Dictyostelium discoideum)
Pi [cytosol]
Nucleotide catabolism (Dictyostelium discoideum)
Purine catabolism (Dictyostelium discoideum)
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Dictyostelium discoideum)
Pi [cytosol]
Pyrimidine catabolism (Dictyostelium discoideum)
(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Dictyostelium discoideum)
Pi [cytosol]
Nucleotide salvage (Dictyostelium discoideum)
Pyrimidine salvage (Dictyostelium discoideum)
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Dictyostelium discoideum)
Pi [cytosol]
Metabolism of porphyrins (Dictyostelium discoideum)
Heme biosynthesis (Dictyostelium discoideum)
ABCG2 tetramer transports heme from cytosol to extracellular region (Dictyostelium discoideum)
Pi [cytosol]
Heme degradation (Dictyostelium discoideum)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Dictyostelium discoideum)
Pi [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Dictyostelium discoideum)
Pi [cytosol]
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of water-soluble vitamins and cofactors (Dictyostelium discoideum)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Dictyostelium discoideum)
Transport of RCbl within the body (Dictyostelium discoideum)
ABCC1 transports cytosolic RCbl to extracellular region (Dictyostelium discoideum)
Pi [cytosol]
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Dictyostelium discoideum)
Pi [cytosol]
Uptake of dietary cobalamins into enterocytes (Dictyostelium discoideum)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Dictyostelium discoideum)
Pi [cytosol]
Metabolism of folate and pterines (Dictyostelium discoideum)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Dictyostelium discoideum)
Pi [cytosol]
FPGS-2 transforms THF to THFPG (Dictyostelium discoideum)
Pi [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Dictyostelium discoideum)
Pi [cytosol]
Nicotinate metabolism (Dictyostelium discoideum)
Nicotinamide salvage (Dictyostelium discoideum)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Dictyostelium discoideum)
Pi [cytosol]
Vitamin B5 (pantothenate) metabolism (Dictyostelium discoideum)
PANK4 hydrolyzes PPANT to pantetheine (Dictyostelium discoideum)
Pi [cytosol]
Pyrophosphate hydrolysis (Dictyostelium discoideum)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Dictyostelium discoideum)
Pi [cytosol]
Metabolism of proteins (Dictyostelium discoideum)
Post-translational protein modification (Dictyostelium discoideum)
Asparagine N-linked glycosylation (Dictyostelium discoideum)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Dictyostelium discoideum)
Synthesis of substrates in N-glycan biosythesis (Dictyostelium discoideum)
Synthesis of dolichyl-phosphate (Dictyostelium discoideum)
DOLPP1 dephosphorylates DOLDP to DOLP (Dictyostelium discoideum)
Pi [cytosol]
MVD decarboxylates MVA5PP to IPPP (Dictyostelium discoideum)
Pi [cytosol]
Transport to the Golgi and subsequent modification (Dictyostelium discoideum)
ER to Golgi Anterograde Transport (Dictyostelium discoideum)
COPI-mediated anterograde transport (Dictyostelium discoideum)
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Dictyostelium discoideum)
Pi [cytosol]
COPII-mediated vesicle transport (Dictyostelium discoideum)
Loss of SAR1B GTPase (Dictyostelium discoideum)
Pi [cytosol]
NSF ATPase activity dissociates cis-SNARE (Dictyostelium discoideum)
Pi [cytosol]
PP6 dephosphorylates SEC24 (Dictyostelium discoideum)
Pi [cytosol]
Carboxyterminal post-translational modifications of tubulin (Dictyostelium discoideum)
TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Dictyostelium discoideum)
Pi [cytosol]
Protein folding (Dictyostelium discoideum)
Chaperonin-mediated protein folding (Dictyostelium discoideum)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Dictyostelium discoideum)
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Dictyostelium discoideum)
Pi [cytosol]
Surfactant metabolism (Dictyostelium discoideum)
ABCA3 transports PC, PG from ER membrane to lamellar body (Dictyostelium discoideum)
Pi [cytosol]
Translation (Dictyostelium discoideum)
Eukaryotic Translation Initiation (Dictyostelium discoideum)
Cap-dependent Translation Initiation (Dictyostelium discoideum)
GTP hydrolysis and joining of the 60S ribosomal subunit (Dictyostelium discoideum)
eIF5B:GTP is hydrolyzed and released (Dictyostelium discoideum)
Pi [cytosol]
Ribosomal scanning and start codon recognition (Dictyostelium discoideum)
Ribosomal scanning (Dictyostelium discoideum)
Pi [cytosol]
tRNA Aminoacylation (Dictyostelium discoideum)
Cytosolic tRNA aminoacylation (Dictyostelium discoideum)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Dictyostelium discoideum)
Pi [cytosol]
Neuronal System (Dictyostelium discoideum)
Transmission across Chemical Synapses (Dictyostelium discoideum)
Neurotransmitter receptors and postsynaptic signal transmission (Dictyostelium discoideum)
GABA receptor activation (Dictyostelium discoideum)
GABA B receptor activation (Dictyostelium discoideum)
Activation of GABAB receptors (Dictyostelium discoideum)
Adenylate cyclase inhibitory pathway (Dictyostelium discoideum)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Dictyostelium discoideum)
Pi [cytosol]
Adenylate cyclase increases the GTPase activity of Gi alpha (Dictyostelium discoideum)
Pi [cytosol]
Sensory Perception (Dictyostelium discoideum)
Visual phototransduction (Dictyostelium discoideum)
The canonical retinoid cycle in rods (twilight vision) (Dictyostelium discoideum)
ABCA4 mediates atRAL transport (Dictyostelium discoideum)
Pi [cytosol]
Signal Transduction (Dictyostelium discoideum)
Intracellular signaling by second messengers (Dictyostelium discoideum)
PIP3 activates AKT signaling (Dictyostelium discoideum)
Negative regulation of the PI3K/AKT network (Dictyostelium discoideum)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Dictyostelium discoideum)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Dictyostelium discoideum)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
Pi [cytosol]
MAPK family signaling cascades (Dictyostelium discoideum)
MAPK1/MAPK3 signaling (Dictyostelium discoideum)
RAF-independent MAPK1/3 activation (Dictyostelium discoideum)
Cytosolic DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)
Pi [cytosol]
RAF/MAP kinase cascade (Dictyostelium discoideum)
Negative regulation of MAPK pathway (Dictyostelium discoideum)
Cytosolic DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)
Pi [cytosol]
PTPN7 dephosphorylates p-T,Y-MAPKs (Dictyostelium discoideum)
Pi [cytosol]
MTOR signalling (Dictyostelium discoideum)
Energy dependent regulation of mTOR by LKB1-AMPK (Dictyostelium discoideum)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Dictyostelium discoideum)
Pi [cytosol]
Signaling by GPCR (Dictyostelium discoideum)
GPCR downstream signalling (Dictyostelium discoideum)
G alpha (i) signalling events (Dictyostelium discoideum)
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Dictyostelium discoideum)
Pi [cytosol]
Opioid Signalling (Dictyostelium discoideum)
G-protein mediated events (Dictyostelium discoideum)
Adenylate cyclase activating pathway (Dictyostelium discoideum)
Adenylaye cyclase increases the GTPase activity of G alpha-olf (Dictyostelium discoideum)
Pi [cytosol]
Adenylate cyclase inhibitory pathway (Dictyostelium discoideum)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Dictyostelium discoideum)
Pi [cytosol]
Adenylate cyclase increases the GTPase activity of Gi alpha (Dictyostelium discoideum)
Pi [cytosol]
PLC beta mediated events (Dictyostelium discoideum)
Inactivation of PLC beta (Dictyostelium discoideum)
Pi [cytosol]
G alpha (q) signalling events (Dictyostelium discoideum)
G alpha (q) in G (q):RGS complex is inactivated (Dictyostelium discoideum)
Pi [cytosol]
G alpha (z) signalling events (Dictyostelium discoideum)
G alpha (z) in G alpha (z):RGS complex is inactivated (Dictyostelium discoideum)
Pi [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Dictyostelium discoideum)
Miro GTPase Cycle (Dictyostelium discoideum)
RHOT1 GTPase cycle (Dictyostelium discoideum)
RHOT1 hydrolyzes GTP (Dictyostelium discoideum)
Pi [cytosol]
RHOT2 GTPase cycle (Dictyostelium discoideum)
RHOT2 hydrolyzes GTP (Dictyostelium discoideum)
Pi [cytosol]
RHOBTB3 ATPase cycle (Dictyostelium discoideum)
RHOBTB3 hydrolyzes ATP (Dictyostelium discoideum)
Pi [cytosol]
Signaling by Rho GTPases (Dictyostelium discoideum)
RHO GTPase cycle (Dictyostelium discoideum)
CDC42 GTPase cycle (Dictyostelium discoideum)
CDC42 GAPs stimulate CDC42 GTPase activity (Dictyostelium discoideum)
Pi [cytosol]
RAC1 GTPase cycle (Dictyostelium discoideum)
RAC1 GAPs stimulate RAC1 GTPase activity (Dictyostelium discoideum)
Pi [cytosol]
RAC2 GTPase cycle (Dictyostelium discoideum)
RAC2 GAPs stimulate RAC2 GTPase activity (Dictyostelium discoideum)
Pi [cytosol]
RAC3 GTPase cycle (Dictyostelium discoideum)
RAC3 GAPs stimulate RAC3 GTPase activity (Dictyostelium discoideum)
Pi [cytosol]
RHOJ GTPase cycle (Dictyostelium discoideum)
RHOJ GAPs stimulate RHOJ GTPase activity (Dictyostelium discoideum)
Pi [cytosol]
RHOQ GTPase cycle (Dictyostelium discoideum)
RHOQ GAPs stimulate RHOQ GTPase activity (Dictyostelium discoideum)
Pi [cytosol]
Transport of small molecules (Dictyostelium discoideum)
ABC-family proteins mediated transport (Dictyostelium discoideum)
ABC transporters in lipid homeostasis (Dictyostelium discoideum)
ABCA12 transports lipids from cytosol to extracellular region (Dictyostelium discoideum)
Pi [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Dictyostelium discoideum)
Pi [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Dictyostelium discoideum)
Pi [cytosol]
ABCAs mediate lipid efflux (Dictyostelium discoideum)
Pi [cytosol]
ABCAs mediate lipid influx (Dictyostelium discoideum)
Pi [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Dictyostelium discoideum)
Pi [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Dictyostelium discoideum)
Pi [cytosol]
ABCG4 may mediate cholesterol efflux (Dictyostelium discoideum)
Pi [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Dictyostelium discoideum)
Pi [cytosol]
ABCA4 mediates atRAL transport (Dictyostelium discoideum)
Pi [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Dictyostelium discoideum)
Pi [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Dictyostelium discoideum)
Pi [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Dictyostelium discoideum)
Pi [cytosol]
HCO3- transport through ion channel (Dictyostelium discoideum)
Pi [cytosol]
The ABCC family mediates organic anion transport (Dictyostelium discoideum)
Pi [cytosol]
Ion channel transport (Dictyostelium discoideum)
Ion transport by P-type ATPases (Dictyostelium discoideum)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Dictyostelium discoideum)
Pi [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Dictyostelium discoideum)
Pi [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Dictyostelium discoideum)
Pi [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Dictyostelium discoideum)
Pi [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Dictyostelium discoideum)
Pi [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Dictyostelium discoideum)
Pi [cytosol]
Stimuli-sensing channels (Dictyostelium discoideum)
SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Dictyostelium discoideum)
Pi [cytosol]
Iron uptake and transport (Dictyostelium discoideum)
ABCG2 tetramer transports heme from cytosol to extracellular region (Dictyostelium discoideum)
Pi [cytosol]
Transferrin endocytosis and recycling (Dictyostelium discoideum)
Acidification of Tf:TfR1 containing endosome (Dictyostelium discoideum)
Pi [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Dictyostelium discoideum)
Plasma lipoprotein remodeling (Dictyostelium discoideum)
HDL remodeling (Dictyostelium discoideum)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Dictyostelium discoideum)
Pi [cytosol]
SLC-mediated transmembrane transport (Dictyostelium discoideum)
Transport of inorganic cations/anions and amino acids/oligopeptides (Dictyostelium discoideum)
Organic anion transporters (Dictyostelium discoideum)
SLC25A10 mediates exchange of malate and phosphate (Dictyostelium discoideum)
Pi [cytosol]
Type I Na+-coupled phosphate co-transport (Dictyostelium discoideum)
Pi [cytosol]
Vesicle-mediated transport (Dictyostelium discoideum)
Membrane Trafficking (Dictyostelium discoideum)
ER to Golgi Anterograde Transport (Dictyostelium discoideum)
COPI-mediated anterograde transport (Dictyostelium discoideum)
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Dictyostelium discoideum)
Pi [cytosol]
COPII-mediated vesicle transport (Dictyostelium discoideum)
Loss of SAR1B GTPase (Dictyostelium discoideum)
Pi [cytosol]
NSF ATPase activity dissociates cis-SNARE (Dictyostelium discoideum)
Pi [cytosol]
PP6 dephosphorylates SEC24 (Dictyostelium discoideum)
Pi [cytosol]
Endosomal Sorting Complex Required For Transport (ESCRT) (Dictyostelium discoideum)
ESCRT Disassembly (Dictyostelium discoideum)
Pi [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Dictyostelium discoideum)
Golgi-to-ER retrograde transport (Dictyostelium discoideum)
COPI-dependent Golgi-to-ER retrograde traffic (Dictyostelium discoideum)
NSF ATPase activity dissociates cis-SNARE at the ER (Dictyostelium discoideum)
Pi [cytosol]
Rab regulation of trafficking (Dictyostelium discoideum)
TBC/RABGAPs (Dictyostelium discoideum)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Dictyostelium discoideum)
Pi [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Dictyostelium discoideum)
Pi [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Dictyostelium discoideum)
Pi [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Dictyostelium discoideum)
Pi [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Dictyostelium discoideum)
Pi [cytosol]
Autophagy (Drosophila melanogaster)
Macroautophagy (Drosophila melanogaster)
ULK1 is dephosphorylated (Drosophila melanogaster)
Pi [cytosol]
Cell Cycle (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
M Phase (Drosophila melanogaster)
Mitotic Metaphase and Anaphase (Drosophila melanogaster)
Mitotic Anaphase (Drosophila melanogaster)
Nuclear Envelope (NE) Reassembly (Drosophila melanogaster)
Initiation of Nuclear Envelope (NE) Reformation (Drosophila melanogaster)
PP2A dephosphorylates BANF1 (Drosophila melanogaster)
Pi [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Drosophila melanogaster)
RAN stimulates fusion of nuclear envelope (NE) membranes (Drosophila melanogaster)
Pi [cytosol]
Mitotic Prometaphase (Drosophila melanogaster)
Condensation of Prometaphase Chromosomes (Drosophila melanogaster)
Dephosphorylation of CK2-modified condensin I (Drosophila melanogaster)
Pi [cytosol]
Resolution of Sister Chromatid Cohesion (Drosophila melanogaster)
PPP1CC dephosphorylates PLK1 (Drosophila melanogaster)
Pi [cytosol]
Mitotic G2-G2/M phases (Drosophila melanogaster)
G2/M Transition (Drosophila melanogaster)
Cyclin A/B1/B2 associated events during G2/M transition (Drosophila melanogaster)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Drosophila melanogaster)
Pi [cytosol]
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to mechanical stimuli (Drosophila melanogaster)
Response of endothelial cells to shear stress (Drosophila melanogaster)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Drosophila melanogaster)
PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) (Drosophila melanogaster)
Pi [cytosol]
Cellular responses to stress (Drosophila melanogaster)
Cellular response to starvation (Drosophila melanogaster)
Amino acids regulate mTORC1 (Drosophila melanogaster)
RRAGA,B hydrolyzes GTP (Drosophila melanogaster)
Pi [cytosol]
RRAGC,D hydrolyzes GTP (Drosophila melanogaster)
Pi [cytosol]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Drosophila melanogaster)
ATP hydrolysis by HSP70 (Drosophila melanogaster)
Pi [cytosol]
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
EPH-Ephrin signaling (Drosophila melanogaster)
EPHB-mediated forward signaling (Drosophila melanogaster)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Drosophila melanogaster)
Pi [cytosol]
L1CAM interactions (Drosophila melanogaster)
Recycling pathway of L1 (Drosophila melanogaster)
Formation of clathrin coated vesicle (Drosophila melanogaster)
Pi [cytosol]
Drosophila signaling pathways (Drosophila melanogaster)
Circadian Clock pathway (Drosophila melanogaster)
Dephosphorylation of PER (Drosophila melanogaster)
Cytosolic PP2A dephosphorylates phosphorylated PER complexed with DCO (Drosophila melanogaster)
Pi [cytosol]
Cytosolic PP2A dephosphorylates phosphorylated PER complexed with TIM and DCO (Drosophila melanogaster)
Pi [cytosol]
Dephosphorylation of TIM (Drosophila melanogaster)
PP1 dephosphorylates phosphorylated TIM (Drosophila melanogaster)
Pi [cytosol]
PP1 dephosphorylates phosphorylated TIM in the complex with PER and DCO (Drosophila melanogaster)
Pi [cytosol]
Imd pathway (Drosophila melanogaster)
Formation of the cytosolic BSK 'scaffolding complex' (Drosophila melanogaster)
Phosphorylated BSK kinase is dephosphorylated and deactivated by PUC phosphatase (Drosophila melanogaster)
Pi [cytosol]
Phosphorylated BSK kinase is dephosphorylated and deactivated by PUC phosphatase (Drosophila melanogaster)
Pi [cytosol]
Insulin receptor mediated signaling (Drosophila melanogaster)
Insulin signaling pathway (Drosophila melanogaster)
PIP3 dephosphorylated to PIP2 by DPTEN (Drosophila melanogaster)
Pi [cytosol]
TOR signaling pathway (Drosophila melanogaster)
DRheb is inhibited by the TSC1/2 complex (Drosophila melanogaster)
Pi [cytosol]
JAK/STAT pathway (Drosophila melanogaster)
Dephosphorylation by PTP61F phosphatases (Drosophila melanogaster)
Phosphorylated HOP is dephosphorylated by PTP61F isoform 1 (Drosophila melanogaster)
Pi [cytosol]
Phosphorylated STAT92E dimer is dephosphorylated by PTP61F isoform 1 (Drosophila melanogaster)
Pi [cytosol]
Planar Cell Polarity pathway (Drosophila melanogaster)
Activation of Downstream Effectors (Drosophila melanogaster)
JNK signalling (Drosophila melanogaster)
Formation of the cytosolic BSK 'scaffolding complex' (Drosophila melanogaster)
Phosphorylated BSK kinase is dephosphorylated and deactivated by PUC phosphatase (Drosophila melanogaster)
Pi [cytosol]
RHO1 signalling (Drosophila melanogaster)
RHO1 GTPase cycle (Drosophila melanogaster)
RHOGAPP190 activates GTP hydrolysis by RHO1:GTP (Drosophila melanogaster)
Pi [cytosol]
Regulation of non-muscle Myosin II (Drosophila melanogaster)
FLW:MBS complex dephosphorylates SQH (Drosophila melanogaster)
Pi [cytosol]
FLW:MYPT-75D complex dephosphorylates SQH (Drosophila melanogaster)
Pi [cytosol]
PP1-87B:MBS complex dephosphorylates SQH (Drosophila melanogaster)
Pi [cytosol]
Wingless pathway (Drosophila melanogaster)
WG ligand bound to FZ receptors (Drosophila melanogaster)
Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM (Drosophila melanogaster)
Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM (Drosophila melanogaster)
Pi [cytosol]
Drug ADME (Drosophila melanogaster)
Aspirin ADME (Drosophila melanogaster)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Drosophila melanogaster)
Pi [cytosol]
Azathioprine ADME (Drosophila melanogaster)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Drosophila melanogaster)
Pi [cytosol]
Paracetamol ADME (Drosophila melanogaster)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Drosophila melanogaster)
Pi [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Drosophila melanogaster)
Pi [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Drosophila melanogaster)
Pi [cytosol]
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional Regulation by TP53 (Drosophila melanogaster)
TP53 Regulates Metabolic Genes (Drosophila melanogaster)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Drosophila melanogaster)
Pi [cytosol]
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
Platelet Aggregation (Plug Formation) (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)
Pi [cytosol]
Response to elevated platelet cytosolic Ca2+ (Drosophila melanogaster)
Platelet degranulation (Drosophila melanogaster)
ABCC4 accumulation of dense granule contents (Drosophila melanogaster)
Pi [cytosol]
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Regulation of T cell activation by CD28 family (Drosophila melanogaster)
Co-inhibition by CTLA4 (Drosophila melanogaster)
Dephosphorylation of AKT by PP2A (Drosophila melanogaster)
Pi [cytosol]
TCR signaling (Drosophila melanogaster)
Downstream TCR signaling (Drosophila melanogaster)
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
Pi [cytosol]
Cytokine Signaling in Immune system (Drosophila melanogaster)
Signaling by CSF3 (G-CSF) (Drosophila melanogaster)
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Drosophila melanogaster)
Pi [cytosol]
Innate Immune System (Drosophila melanogaster)
C-type lectin receptors (CLRs) (Drosophila melanogaster)
CLEC7A (Dectin-1) signaling (Drosophila melanogaster)
CLEC7A (Dectin-1) induces NFAT activation (Drosophila melanogaster)
Calcineurin binds and dephosphorylates NFAT (Drosophila melanogaster)
Pi [cytosol]
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated Ca+2 mobilization (Drosophila melanogaster)
Calcineurin binds and dephosphorylates NFAT (Drosophila melanogaster)
Pi [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Drosophila melanogaster)
Role of phospholipids in phagocytosis (Drosophila melanogaster)
Conversion of PA into DAG by PAP-1 (Drosophila melanogaster)
Pi [cytosol]
Metabolism (Drosophila melanogaster)
Aerobic respiration and respiratory electron transport (Drosophila melanogaster)
Pyruvate metabolism (Drosophila melanogaster)
Regulation of pyruvate metabolism (Drosophila melanogaster)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Drosophila melanogaster)
Pi [cytosol]
Biological oxidations (Drosophila melanogaster)
Phase II - Conjugation of compounds (Drosophila melanogaster)
Cytosolic sulfonation of small molecules (Drosophila melanogaster)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Drosophila melanogaster)
Pi [cytosol]
Glutathione conjugation (Drosophila melanogaster)
Glutathione synthesis and recycling (Drosophila melanogaster)
GCL ligates L-Glu to L-Cys (Drosophila melanogaster)
Pi [cytosol]
GSS:Mg2+ dimer synthesizes GSH (Drosophila melanogaster)
Pi [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Drosophila melanogaster)
Pi [cytosol]
Inositol phosphate metabolism (Drosophila melanogaster)
Synthesis of IP2, IP, and Ins in the cytosol (Drosophila melanogaster)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Drosophila melanogaster)
Pi [cytosol]
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Drosophila melanogaster)
Pi [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Drosophila melanogaster)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Drosophila melanogaster)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Drosophila melanogaster)
Pi [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Drosophila melanogaster)
Pi [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)
Pi [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)
Pi [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)
Pi [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Drosophila melanogaster)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Drosophila melanogaster)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Drosophila melanogaster)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Drosophila melanogaster)
Pi [cytosol]
Synthesis of pyrophosphates in the cytosol (Drosophila melanogaster)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Drosophila melanogaster)
Pi [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Drosophila melanogaster)
Pi [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Drosophila melanogaster)
Pi [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Drosophila melanogaster)
Pi [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Drosophila melanogaster)
Pi [cytosol]
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Glutamate and glutamine metabolism (Drosophila melanogaster)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Drosophila melanogaster)
Pi [cytosol]
Selenoamino acid metabolism (Drosophila melanogaster)
Selenocysteine synthesis (Drosophila melanogaster)
SEPHS2 phosphorylates H2Se to form SELP (Drosophila melanogaster)
Pi [cytosol]
Serine metabolism (Drosophila melanogaster)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Drosophila melanogaster)
Pi [cytosol]
Sulfur amino acid metabolism (Drosophila melanogaster)
Methionine salvage pathway (Drosophila melanogaster)
Acireductone is created (Drosophila melanogaster)
Pi [cytosol]
MTA is cleaved and phosphorylated (Drosophila melanogaster)
Pi [cytosol]
Metabolism of carbohydrates and carbohydrate derivatives (Drosophila melanogaster)
Glucose metabolism (Drosophila melanogaster)
Gluconeogenesis (Drosophila melanogaster)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Drosophila melanogaster)
Pi [cytosol]
GAPDH tetramers reduce 1,3BPG to GA3P (Drosophila melanogaster)
Pi [cytosol]
SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Drosophila melanogaster)
Pi [cytosol]
Glycolysis (Drosophila melanogaster)
GADPH tetramer dehydrogenates GA3P (Drosophila melanogaster)
Pi [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Drosophila melanogaster)
PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (Drosophila melanogaster)
Pi [cytosol]
Glycogen metabolism (Drosophila melanogaster)
Glycogen synthesis (Drosophila melanogaster)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Drosophila melanogaster)
Pi [cytosol]
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Drosophila melanogaster)
Pi [cytosol]
Metabolism of lipids (Drosophila melanogaster)
Fatty acid metabolism (Drosophila melanogaster)
Arachidonate metabolism (Drosophila melanogaster)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Drosophila melanogaster)
LTC4 is exported from the cytosol by ABCC1 (Drosophila melanogaster)
Pi [cytosol]
Carnitine shuttle (Drosophila melanogaster)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Drosophila melanogaster)
Pi [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Drosophila melanogaster)
Pi [cytosol]
Fatty acyl-CoA biosynthesis (Drosophila melanogaster)
ACLY tetramer transforms CIT to Ac-CoA (Drosophila melanogaster)
Pi [cytosol]
Formation of Malonyl-CoA from Acetyl-CoA (liver) (Drosophila melanogaster)
Pi [cytosol]
Metabolism of steroids (Drosophila melanogaster)
Bile acid and bile salt metabolism (Drosophila melanogaster)
Recycling of bile acids and salts (Drosophila melanogaster)
ABCC3 transports bile salts from cytosol to extracellular region (Drosophila melanogaster)
Pi [cytosol]
Cholesterol biosynthesis (Drosophila melanogaster)
MVD decarboxylates MVA5PP to IPPP (Drosophila melanogaster)
Pi [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Drosophila melanogaster)
Pi [cytosol]
Phospholipid metabolism (Drosophila melanogaster)
Glycerophospholipid biosynthesis (Drosophila melanogaster)
PGP:Mg2+ dimer hydrolyses G3P to glycerol (Drosophila melanogaster)
Pi [cytosol]
Synthesis of PC (Drosophila melanogaster)
PA is dephosphorylated to DAG by LPIN (Drosophila melanogaster)
Pi [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Drosophila melanogaster)
Pi [cytosol]
Synthesis of PE (Drosophila melanogaster)
PA is dephosphorylated to DAG by LPIN (Drosophila melanogaster)
Pi [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Drosophila melanogaster)
Pi [cytosol]
PI Metabolism (Drosophila melanogaster)
Synthesis of PIPs at the ER membrane (Drosophila melanogaster)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Drosophila melanogaster)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Drosophila melanogaster)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Drosophila melanogaster)
Pi [cytosol]
Synthesis of PIPs at the Golgi membrane (Drosophila melanogaster)
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Drosophila melanogaster)
Pi [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Drosophila melanogaster)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Drosophila melanogaster)
Pi [cytosol]
Synthesis of PIPs at the early endosome membrane (Drosophila melanogaster)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Drosophila melanogaster)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Drosophila melanogaster)
Pi [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Drosophila melanogaster)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Drosophila melanogaster)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Drosophila melanogaster)
Pi [cytosol]
Synthesis of PIPs at the late endosome membrane (Drosophila melanogaster)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Drosophila melanogaster)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Drosophila melanogaster)
Pi [cytosol]
Synthesis of PIPs at the plasma membrane (Drosophila melanogaster)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Drosophila melanogaster)
Pi [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Drosophila melanogaster)
Pi [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Drosophila melanogaster)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Drosophila melanogaster)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Drosophila melanogaster)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Drosophila melanogaster)
Pi [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Drosophila melanogaster)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Drosophila melanogaster)
Pi [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Drosophila melanogaster)
Pi [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Drosophila melanogaster)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
Pi [cytosol]
Sphingolipid metabolism (Drosophila melanogaster)
Sphingolipid catabolism (Drosophila melanogaster)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Drosophila melanogaster)
Pi [cytosol]
Sphingolipid de novo biosynthesis (Drosophila melanogaster)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Drosophila melanogaster)
Pi [cytosol]
PPM1L dephosphorylates multiphospho-CERT1-2 (Drosophila melanogaster)
Pi [cytosol]
Triglyceride metabolism (Drosophila melanogaster)
Triglyceride biosynthesis (Drosophila melanogaster)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Drosophila melanogaster)
Pi [cytosol]
Metabolism of nucleotides (Drosophila melanogaster)
Interconversion of nucleotide di- and triphosphates (Drosophila melanogaster)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Drosophila melanogaster)
Pi [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Drosophila melanogaster)
Pi [cytosol]
Nucleotide biosynthesis (Drosophila melanogaster)
Purine ribonucleoside monophosphate biosynthesis (Drosophila melanogaster)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Drosophila melanogaster)
Pi [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Drosophila melanogaster)
Pi [cytosol]
FGAM + ATP => AIR + ADP + Pi (Drosophila melanogaster)
Pi [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Drosophila melanogaster)
Pi [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Drosophila melanogaster)
Pi [cytosol]
Pyrimidine biosynthesis (Drosophila melanogaster)
CAD hexamer transforms CAP to N-carb-L-Asp (Drosophila melanogaster)
Pi [cytosol]
CAD hexamer transforms L-Gln to CAP (Drosophila melanogaster)
Pi [cytosol]
Nucleotide catabolism (Drosophila melanogaster)
Purine catabolism (Drosophila melanogaster)
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Drosophila melanogaster)
Pi [cytosol]
PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Drosophila melanogaster)
Pi [cytosol]
PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Drosophila melanogaster)
Pi [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Drosophila melanogaster)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Drosophila melanogaster)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Drosophila melanogaster)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Drosophila melanogaster)
Pi [cytosol]
Pyrimidine catabolism (Drosophila melanogaster)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Drosophila melanogaster)
Pi [cytosol]
(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Drosophila melanogaster)
Pi [cytosol]
Nucleotide salvage (Drosophila melanogaster)
Purine salvage (Drosophila melanogaster)
PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Drosophila melanogaster)
Pi [cytosol]
PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Drosophila melanogaster)
Pi [cytosol]
Pyrimidine salvage (Drosophila melanogaster)
HDHD1:Mg2+ dephosphorylates PURIDP (Drosophila melanogaster)
Pi [cytosol]
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Drosophila melanogaster)
Pi [cytosol]
Metabolism of porphyrins (Drosophila melanogaster)
Heme biosynthesis (Drosophila melanogaster)
ABCG2 tetramer transports heme from cytosol to extracellular region (Drosophila melanogaster)
Pi [cytosol]
Heme degradation (Drosophila melanogaster)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Drosophila melanogaster)
Pi [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Drosophila melanogaster)
Pi [cytosol]
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of water-soluble vitamins and cofactors (Drosophila melanogaster)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Drosophila melanogaster)
Transport of RCbl within the body (Drosophila melanogaster)
ABCC1 transports cytosolic RCbl to extracellular region (Drosophila melanogaster)
Pi [cytosol]
Metabolism of folate and pterines (Drosophila melanogaster)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Drosophila melanogaster)
Pi [cytosol]
FPGS-2 transforms THF to THFPG (Drosophila melanogaster)
Pi [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Drosophila melanogaster)
Pi [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Drosophila melanogaster)
Pi [cytosol]
Nicotinate metabolism (Drosophila melanogaster)
Nicotinamide salvage (Drosophila melanogaster)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Drosophila melanogaster)
Pi [cytosol]
Pyrophosphate hydrolysis (Drosophila melanogaster)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Drosophila melanogaster)
Pi [cytosol]
Metabolism of RNA (Drosophila melanogaster)
Deadenylation-dependent mRNA decay (Drosophila melanogaster)
mRNA decay by 3' to 5' exoribonuclease (Drosophila melanogaster)
NT5C3B hydrolyses 7MGP to 7MG (Drosophila melanogaster)
Pi [cytosol]
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Asparagine N-linked glycosylation (Drosophila melanogaster)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Drosophila melanogaster)
Synthesis of substrates in N-glycan biosythesis (Drosophila melanogaster)
Sialic acid metabolism (Drosophila melanogaster)
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Drosophila melanogaster)
Pi [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Drosophila melanogaster)
Pi [cytosol]
Synthesis of dolichyl-phosphate (Drosophila melanogaster)
MVD decarboxylates MVA5PP to IPPP (Drosophila melanogaster)
Pi [cytosol]
Transport to the Golgi and subsequent modification (Drosophila melanogaster)
ER to Golgi Anterograde Transport (Drosophila melanogaster)
COPII-mediated vesicle transport (Drosophila melanogaster)
Loss of SAR1B GTPase (Drosophila melanogaster)
Pi [cytosol]
NSF ATPase activity dissociates cis-SNARE (Drosophila melanogaster)
Pi [cytosol]
Protein folding (Drosophila melanogaster)
Chaperonin-mediated protein folding (Drosophila melanogaster)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Drosophila melanogaster)
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Drosophila melanogaster)
Pi [cytosol]
Surfactant metabolism (Drosophila melanogaster)
ABCA3 transports PC, PG from ER membrane to lamellar body (Drosophila melanogaster)
Pi [cytosol]
Translation (Drosophila melanogaster)
Eukaryotic Translation Initiation (Drosophila melanogaster)
Cap-dependent Translation Initiation (Drosophila melanogaster)
GTP hydrolysis and joining of the 60S ribosomal subunit (Drosophila melanogaster)
eIF5B:GTP is hydrolyzed and released (Drosophila melanogaster)
Pi [cytosol]
Ribosomal scanning and start codon recognition (Drosophila melanogaster)
Ribosomal scanning (Drosophila melanogaster)
Pi [cytosol]
tRNA Aminoacylation (Drosophila melanogaster)
Cytosolic tRNA aminoacylation (Drosophila melanogaster)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Drosophila melanogaster)
Pi [cytosol]
Muscle contraction (Drosophila melanogaster)
Smooth Muscle Contraction (Drosophila melanogaster)
ATP Hydrolysis By Myosin (Drosophila melanogaster)
Pi [cytosol]
Neuronal System (Drosophila melanogaster)
Transmission across Chemical Synapses (Drosophila melanogaster)
Neurotransmitter receptors and postsynaptic signal transmission (Drosophila melanogaster)
GABA receptor activation (Drosophila melanogaster)
GABA B receptor activation (Drosophila melanogaster)
Activation of GABAB receptors (Drosophila melanogaster)
Adenylate cyclase inhibitory pathway (Drosophila melanogaster)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Drosophila melanogaster)
Pi [cytosol]
Adenylate cyclase increases the GTPase activity of Gi alpha (Drosophila melanogaster)
Pi [cytosol]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Drosophila melanogaster)
Trafficking of AMPA receptors (Drosophila melanogaster)
Trafficking of GluR2-containing AMPA receptors (Drosophila melanogaster)
Endocytosis of Ca impermeable AMPA receptors (Drosophila melanogaster)
Pi [cytosol]
Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Drosophila melanogaster)
Pi [cytosol]
Trafficking of GluR2-containing AMPA receptors to synapse (Drosophila melanogaster)
Pi [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Drosophila melanogaster)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Drosophila melanogaster)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Drosophila melanogaster)
Pi [cytosol]
Organelle biogenesis and maintenance (Drosophila melanogaster)
Cilium Assembly (Drosophila melanogaster)
Cargo trafficking to the periciliary membrane (Drosophila melanogaster)
VxPx cargo-targeting to cilium (Drosophila melanogaster)
ASAP1 stimulates GTPase activity of ARF4 (Drosophila melanogaster)
Pi [cytosol]
Sensory Perception (Drosophila melanogaster)
Visual phototransduction (Drosophila melanogaster)
The canonical retinoid cycle in rods (twilight vision) (Drosophila melanogaster)
ABCA4 mediates atRAL transport (Drosophila melanogaster)
Pi [cytosol]
Signal Transduction (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)
Pi [cytosol]
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
PHLPP dephosphorylates S473 in AKT (Drosophila melanogaster)
Pi [cytosol]
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Drosophila melanogaster)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Drosophila melanogaster)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
Pi [cytosol]
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF-independent MAPK1/3 activation (Drosophila melanogaster)
Cytosolic DUSPs dephosphorylate MAPKs (Drosophila melanogaster)
Pi [cytosol]
RAF/MAP kinase cascade (Drosophila melanogaster)
Negative regulation of MAPK pathway (Drosophila melanogaster)
Cytosolic DUSPs dephosphorylate MAPKs (Drosophila melanogaster)
Pi [cytosol]
PP2A dephosphorylates RAF1 (Drosophila melanogaster)
Pi [cytosol]
PP5 dephosphorylates RAF1 S338 (Drosophila melanogaster)
Pi [cytosol]
PTPN3 dephosphorylates MAPK12 (Drosophila melanogaster)
Pi [cytosol]
PTPN7 dephosphorylates p-T,Y-MAPKs (Drosophila melanogaster)
Pi [cytosol]
RAF activation (Drosophila melanogaster)
PP2A dephosphorylates KSR1 (Drosophila melanogaster)
Pi [cytosol]
PP2A dephosphorylates inactive RAFs (Drosophila melanogaster)
Pi [cytosol]
MTOR signalling (Drosophila melanogaster)
Energy dependent regulation of mTOR by LKB1-AMPK (Drosophila melanogaster)
AMPK is dephosphorylated (Drosophila melanogaster)
Pi [cytosol]
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Drosophila melanogaster)
Pi [cytosol]
Signaling by GPCR (Drosophila melanogaster)
GPCR downstream signalling (Drosophila melanogaster)
G alpha (i) signalling events (Drosophila melanogaster)
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Drosophila melanogaster)
Pi [cytosol]
Opioid Signalling (Drosophila melanogaster)
G-protein mediated events (Drosophila melanogaster)
Adenylate cyclase activating pathway (Drosophila melanogaster)
Adenylaye cyclase increases the GTPase activity of G alpha-olf (Drosophila melanogaster)
Pi [cytosol]
Adenylate cyclase inhibitory pathway (Drosophila melanogaster)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Drosophila melanogaster)
Pi [cytosol]
Adenylate cyclase increases the GTPase activity of Gi alpha (Drosophila melanogaster)
Pi [cytosol]
PLC beta mediated events (Drosophila melanogaster)
Inactivation of PLC beta (Drosophila melanogaster)
Pi [cytosol]
G alpha (q) signalling events (Drosophila melanogaster)
G alpha (q) in G (q):RGS complex is inactivated (Drosophila melanogaster)
Pi [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by PTK6 (Drosophila melanogaster)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Drosophila melanogaster)
ARHGAP35 stimulates RHOA GTPase activity (Drosophila melanogaster)
Pi [cytosol]
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by EGFR (Drosophila melanogaster)
EGFR downregulation (Drosophila melanogaster)
PTPN3 dephosphorylates EPS15 (Drosophila melanogaster)
Pi [cytosol]
GAB1 signalosome (Drosophila melanogaster)
Dephosphorylation of Gab1 by SHP2 (Drosophila melanogaster)
Pi [cytosol]
SHP2 dephosphorylates Tyr 992 on EGFR (Drosophila melanogaster)
Pi [cytosol]
Sustained activation of SRC kinase by SHP2 (Drosophila melanogaster)
Pi [cytosol]
Signaling by ERBB2 (Drosophila melanogaster)
Downregulation of ERBB2 signaling (Drosophila melanogaster)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Drosophila melanogaster)
Pi [cytosol]
Signaling by FGFR (Drosophila melanogaster)
Signaling by FGFR1 (Drosophila melanogaster)
Negative regulation of FGFR1 signaling (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
PPA2A dephosphorylates SPRY2 (Drosophila melanogaster)
Pi [cytosol]
Signaling by FGFR2 (Drosophila melanogaster)
Negative regulation of FGFR2 signaling (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
PPA2A dephosphorylates SPRY2 (Drosophila melanogaster)
Pi [cytosol]
Signaling by FGFR3 (Drosophila melanogaster)
Negative regulation of FGFR3 signaling (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
PPA2A dephosphorylates SPRY2 (Drosophila melanogaster)
Pi [cytosol]
Signaling by FGFR4 (Drosophila melanogaster)
Negative regulation of FGFR4 signaling (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
PPA2A dephosphorylates SPRY2 (Drosophila melanogaster)
Pi [cytosol]
Signaling by Insulin receptor (Drosophila melanogaster)
Insulin receptor recycling (Drosophila melanogaster)
Insulin receptor de-phosphorylation (Drosophila melanogaster)
Pi [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Drosophila melanogaster)
Miro GTPase Cycle (Drosophila melanogaster)
RHOT1 GTPase cycle (Drosophila melanogaster)
RHOT1 hydrolyzes GTP (Drosophila melanogaster)
Pi [cytosol]
RHOT2 GTPase cycle (Drosophila melanogaster)
RHOT2 hydrolyzes GTP (Drosophila melanogaster)
Pi [cytosol]
RHOBTB3 ATPase cycle (Drosophila melanogaster)
RHOBTB3 hydrolyzes ATP (Drosophila melanogaster)
Pi [cytosol]
Signaling by Rho GTPases (Drosophila melanogaster)
RHO GTPase cycle (Drosophila melanogaster)
CDC42 GTPase cycle (Drosophila melanogaster)
CDC42 GAPs stimulate CDC42 GTPase activity (Drosophila melanogaster)
Pi [cytosol]
RAC1 GTPase cycle (Drosophila melanogaster)
RAC1 GAPs stimulate RAC1 GTPase activity (Drosophila melanogaster)
Pi [cytosol]
RAC2 GTPase cycle (Drosophila melanogaster)
RAC2 GAPs stimulate RAC2 GTPase activity (Drosophila melanogaster)
Pi [cytosol]
RAC3 GTPase cycle (Drosophila melanogaster)
RAC3 GAPs stimulate RAC3 GTPase activity (Drosophila melanogaster)
Pi [cytosol]
RHOA GTPase cycle (Drosophila melanogaster)
RHOA GAPs stimulate RHOA GTPase activity (Drosophila melanogaster)
Pi [cytosol]
RHOB GTPase cycle (Drosophila melanogaster)
RHOB GAPs stimulate RHOB GTPase activity (Drosophila melanogaster)
Pi [cytosol]
RHOD GTPase cycle (Drosophila melanogaster)
RHOD GAPs stimulate RHOD GTPase activity (Drosophila melanogaster)
Pi [cytosol]
RHOF GTPase cycle (Drosophila melanogaster)
RHOF GAPs stimulate RHOF GTPase activity (Drosophila melanogaster)
Pi [cytosol]
RHOG GTPase cycle (Drosophila melanogaster)
RHOG GAPs stimulate RHOG GTPase activity (Drosophila melanogaster)
Pi [cytosol]
RHOJ GTPase cycle (Drosophila melanogaster)
RHOJ GAPs stimulate RHOJ GTPase activity (Drosophila melanogaster)
Pi [cytosol]
RHOQ GTPase cycle (Drosophila melanogaster)
RHOQ GAPs stimulate RHOQ GTPase activity (Drosophila melanogaster)
Pi [cytosol]
Signaling by TGFB family members (Drosophila melanogaster)
Signaling by TGF-beta Receptor Complex (Drosophila melanogaster)
TGF-beta receptor signaling activates SMADs (Drosophila melanogaster)
Downregulation of TGF-beta receptor signaling (Drosophila melanogaster)
MTMR4 dephosphorylates SMAD2/3 (Drosophila melanogaster)
Pi [cytosol]
Signaling by WNT (Drosophila melanogaster)
Beta-catenin independent WNT signaling (Drosophila melanogaster)
Ca2+ pathway (Drosophila melanogaster)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Drosophila melanogaster)
Pi [cytosol]
Transport of small molecules (Drosophila melanogaster)
ABC-family proteins mediated transport (Drosophila melanogaster)
ABC transporters in lipid homeostasis (Drosophila melanogaster)
ABCA12 transports lipids from cytosol to extracellular region (Drosophila melanogaster)
Pi [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Drosophila melanogaster)
Pi [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Drosophila melanogaster)
Pi [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Drosophila melanogaster)
Pi [cytosol]
ABCG4 may mediate cholesterol efflux (Drosophila melanogaster)
Pi [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Drosophila melanogaster)
Pi [cytosol]
ABCA4 mediates atRAL transport (Drosophila melanogaster)
Pi [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Drosophila melanogaster)
Pi [cytosol]
HCO3- transport through ion channel (Drosophila melanogaster)
Pi [cytosol]
Mitochondrial ABC transporters (Drosophila melanogaster)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Drosophila melanogaster)
Pi [cytosol]
The ABCC family mediates organic anion transport (Drosophila melanogaster)
Pi [cytosol]
Ion channel transport (Drosophila melanogaster)
Ion transport by P-type ATPases (Drosophila melanogaster)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Drosophila melanogaster)
Pi [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Drosophila melanogaster)
Pi [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Drosophila melanogaster)
Pi [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Drosophila melanogaster)
Pi [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Drosophila melanogaster)
Pi [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Drosophila melanogaster)
Pi [cytosol]
Stimuli-sensing channels (Drosophila melanogaster)
SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Drosophila melanogaster)
Pi [cytosol]
Iron uptake and transport (Drosophila melanogaster)
ABCG2 tetramer transports heme from cytosol to extracellular region (Drosophila melanogaster)
Pi [cytosol]
Transferrin endocytosis and recycling (Drosophila melanogaster)
Acidification of Tf:TfR1 containing endosome (Drosophila melanogaster)
Pi [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Drosophila melanogaster)
Plasma lipoprotein remodeling (Drosophila melanogaster)
HDL remodeling (Drosophila melanogaster)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Drosophila melanogaster)
Pi [cytosol]
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of inorganic cations/anions and amino acids/oligopeptides (Drosophila melanogaster)
Organic anion transporters (Drosophila melanogaster)
SLC25A10 mediates exchange of malate and phosphate (Drosophila melanogaster)
Pi [cytosol]
Type I Na+-coupled phosphate co-transport (Drosophila melanogaster)
Pi [cytosol]
Sodium-coupled phosphate cotransporters (Drosophila melanogaster)
SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Drosophila melanogaster)
Pi [cytosol]
Vesicle-mediated transport (Drosophila melanogaster)
Membrane Trafficking (Drosophila melanogaster)
Clathrin-mediated endocytosis (Drosophila melanogaster)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
Pi [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Drosophila melanogaster)
Pi [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
Pi [cytosol]
ER to Golgi Anterograde Transport (Drosophila melanogaster)
COPII-mediated vesicle transport (Drosophila melanogaster)
Loss of SAR1B GTPase (Drosophila melanogaster)
Pi [cytosol]
NSF ATPase activity dissociates cis-SNARE (Drosophila melanogaster)
Pi [cytosol]
Endosomal Sorting Complex Required For Transport (ESCRT) (Drosophila melanogaster)
ESCRT Disassembly (Drosophila melanogaster)
Pi [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Drosophila melanogaster)
Golgi-to-ER retrograde transport (Drosophila melanogaster)
COPI-dependent Golgi-to-ER retrograde traffic (Drosophila melanogaster)
NSF ATPase activity dissociates cis-SNARE at the ER (Drosophila melanogaster)
Pi [cytosol]
Rab regulation of trafficking (Drosophila melanogaster)
TBC/RABGAPs (Drosophila melanogaster)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Drosophila melanogaster)
Pi [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Drosophila melanogaster)
Pi [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Drosophila melanogaster)
Pi [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Drosophila melanogaster)
Pi [cytosol]
trans-Golgi Network Vesicle Budding (Drosophila melanogaster)
Golgi Associated Vesicle Biogenesis (Drosophila melanogaster)
trans-Golgi Network Coat Assembly (Drosophila melanogaster)
Pi [cytosol]
trans-Golgi Network Vesicle Scission (Drosophila melanogaster)
Pi [cytosol]
Lysosome Vesicle Biogenesis (Drosophila melanogaster)
trans-Golgi Network Lysosomal Vesicle Scission (Drosophila melanogaster)
Pi [cytosol]
trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Drosophila melanogaster)
Pi [cytosol]
Autophagy (Gallus gallus)
Macroautophagy (Gallus gallus)
ULK1 is dephosphorylated (Gallus gallus)
Pi [cytosol]
Cell Cycle (Gallus gallus)
Cell Cycle, Mitotic (Gallus gallus)
M Phase (Gallus gallus)
Mitotic Metaphase and Anaphase (Gallus gallus)
Mitotic Anaphase (Gallus gallus)
Nuclear Envelope (NE) Reassembly (Gallus gallus)
Initiation of Nuclear Envelope (NE) Reformation (Gallus gallus)
PP2A dephosphorylates BANF1 (Gallus gallus)
Pi [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Gallus gallus)
RAN stimulates fusion of nuclear envelope (NE) membranes (Gallus gallus)
Pi [cytosol]
Mitotic Prometaphase (Gallus gallus)
Condensation of Prometaphase Chromosomes (Gallus gallus)
Dephosphorylation of CK2-modified condensin I (Gallus gallus)
Pi [cytosol]
Resolution of Sister Chromatid Cohesion (Gallus gallus)
PP2A-B56 dephosphorylates centromeric cohesin (Gallus gallus)
Pi [cytosol]
PPP1CC dephosphorylates PLK1 (Gallus gallus)
Pi [cytosol]
Mitotic G2-G2/M phases (Gallus gallus)
G2/M Transition (Gallus gallus)
Cyclin A/B1/B2 associated events during G2/M transition (Gallus gallus)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Gallus gallus)
Pi [cytosol]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to mechanical stimuli (Gallus gallus)
Response of endothelial cells to shear stress (Gallus gallus)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Gallus gallus)
PP2A dephosphorylates serine-127 of YAP1 (Gallus gallus)
Pi [cytosol]
PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) (Gallus gallus)
Pi [cytosol]
Cellular responses to stress (Gallus gallus)
Cellular response to starvation (Gallus gallus)
Amino acids regulate mTORC1 (Gallus gallus)
RRAGA,B hydrolyzes GTP (Gallus gallus)
Pi [cytosol]
RRAGC,D hydrolyzes GTP (Gallus gallus)
Pi [cytosol]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Gallus gallus)
ATP hydrolysis by HSP70 (Gallus gallus)
Pi [cytosol]
Developmental Biology (Gallus gallus)
Nervous system development (Gallus gallus)
Axon guidance (Gallus gallus)
EPH-Ephrin signaling (Gallus gallus)
EPHB-mediated forward signaling (Gallus gallus)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Gallus gallus)
Pi [cytosol]
L1CAM interactions (Gallus gallus)
Recycling pathway of L1 (Gallus gallus)
Formation of clathrin coated vesicle (Gallus gallus)
Pi [cytosol]
Semaphorin interactions (Gallus gallus)
Sema4D in semaphorin signaling (Gallus gallus)
Sema4D mediated inhibition of cell attachment and migration (Gallus gallus)
Inactivation of Rho-GTP by p190RhoGAP (Gallus gallus)
Pi [cytosol]
Signaling by ROBO receptors (Gallus gallus)
SLIT2:ROBO1 increases RHOA activity (Gallus gallus)
MYO9B inactivates RHOA (Gallus gallus)
Pi [cytosol]
Drug ADME (Gallus gallus)
Aspirin ADME (Gallus gallus)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Gallus gallus)
Pi [cytosol]
Azathioprine ADME (Gallus gallus)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Gallus gallus)
Pi [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Gallus gallus)
Pi [cytosol]
Paracetamol ADME (Gallus gallus)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Gallus gallus)
Pi [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Gallus gallus)
Pi [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Gallus gallus)
Pi [cytosol]
Prednisone ADME (Gallus gallus)
ABCB1 transports PREDN,PREDL out of hepatic cells (Gallus gallus)
Pi [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Gallus gallus)
Pi [cytosol]
ABCB1 transports xenobiotics out of the cell (Gallus gallus)
Pi [cytosol]
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional Regulation by TP53 (Gallus gallus)
TP53 Regulates Metabolic Genes (Gallus gallus)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Gallus gallus)
Pi [cytosol]
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Gallus gallus)
Pi [cytosol]
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
Platelet Aggregation (Plug Formation) (Gallus gallus)
Integrin signaling (Gallus gallus)
Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)
Pi [cytosol]
Response to elevated platelet cytosolic Ca2+ (Gallus gallus)
Platelet degranulation (Gallus gallus)
ABCC4 accumulation of dense granule contents (Gallus gallus)
Pi [cytosol]
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
MHC class II antigen presentation (Gallus gallus)
Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Gallus gallus)
Pi [cytosol]
Internalization of MHC II:Ii clathrin coated vesicle (Gallus gallus)
Pi [cytosol]
Translocation of TGN-lysosome vesicle to lysosome (Gallus gallus)
Pi [cytosol]
TCR signaling (Gallus gallus)
Downstream TCR signaling (Gallus gallus)
Hydrolysis of PIP3 to PI(3,4)P2 (Gallus gallus)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Gallus gallus)
Pi [cytosol]
Phosphorylation of CD3 and TCR zeta chains (Gallus gallus)
Dephosphorylation of Lck-pY505 by CD45 (Gallus gallus)
Pi [cytosol]
Inactivation of LCK by PTPN22 (Gallus gallus)
Pi [cytosol]
Translocation of ZAP-70 to Immunological synapse (Gallus gallus)
PTPN22 dephosphorylates ZAP70 (Gallus gallus)
Pi [cytosol]
Cytokine Signaling in Immune system (Gallus gallus)
Growth hormone receptor signaling (Gallus gallus)
PTP1B dephosphorylates GHR (Gallus gallus)
Pi [cytosol]
Interferon Signaling (Gallus gallus)
Interferon alpha/beta signaling (Gallus gallus)
Regulation of IFNA/IFNB signaling (Gallus gallus)
Dephosphorylation of JAK1 by SHP1 (Gallus gallus)
Pi [cytosol]
Dephosphorylation of STAT1 by SHP2 (Gallus gallus)
Pi [cytosol]
Dephosphorylation of TYK2 by PTP1B (Gallus gallus)
Pi [cytosol]
Signaling by CSF3 (G-CSF) (Gallus gallus)
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Gallus gallus)
Pi [cytosol]
Innate Immune System (Gallus gallus)
Antimicrobial peptides (Gallus gallus)
Ion influx/efflux at host-pathogen interface (Gallus gallus)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Gallus gallus)
Pi [cytosol]
C-type lectin receptors (CLRs) (Gallus gallus)
CLEC7A (Dectin-1) signaling (Gallus gallus)
CLEC7A (Dectin-1) induces NFAT activation (Gallus gallus)
Calcineurin binds and dephosphorylates NFAT (Gallus gallus)
Pi [cytosol]
Fc epsilon receptor (FCERI) signaling (Gallus gallus)
FCERI mediated Ca+2 mobilization (Gallus gallus)
Calcineurin binds and dephosphorylates NFAT (Gallus gallus)
Pi [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Gallus gallus)
Regulation of actin dynamics for phagocytic cup formation (Gallus gallus)
Role of myosins in phagosome formation (Gallus gallus)
Pi [cytosol]
Role of phospholipids in phagocytosis (Gallus gallus)
Conversion of PA into DAG by PAP-1 (Gallus gallus)
Pi [cytosol]
Metabolism (Gallus gallus)
Aerobic respiration and respiratory electron transport (Gallus gallus)
Pyruvate metabolism (Gallus gallus)
Regulation of pyruvate metabolism (Gallus gallus)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Gallus gallus)
Pi [cytosol]
Biological oxidations (Gallus gallus)
Phase II - Conjugation of compounds (Gallus gallus)
Cytosolic sulfonation of small molecules (Gallus gallus)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Gallus gallus)
Pi [cytosol]
Glutathione conjugation (Gallus gallus)
Glutathione synthesis and recycling (Gallus gallus)
GSS:Mg2+ dimer synthesizes GSH (Gallus gallus)
Pi [cytosol]
Methylation (Gallus gallus)
MAT1A multimers transfer Ado from ATP to L-Met (Gallus gallus)
Pi [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Gallus gallus)
Pi [cytosol]
Inositol phosphate metabolism (Gallus gallus)
Synthesis of IP2, IP, and Ins in the cytosol (Gallus gallus)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Gallus gallus)
Pi [cytosol]
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Gallus gallus)
Pi [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Gallus gallus)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Gallus gallus)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Gallus gallus)
Pi [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Gallus gallus)
Pi [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Gallus gallus)
Pi [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Gallus gallus)
Pi [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Gallus gallus)
Pi [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Gallus gallus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Gallus gallus)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Gallus gallus)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Gallus gallus)
Pi [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Gallus gallus)
Pi [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Gallus gallus)
Pi [cytosol]
Synthesis of pyrophosphates in the cytosol (Gallus gallus)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Gallus gallus)
Pi [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Gallus gallus)
Pi [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Gallus gallus)
Pi [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Gallus gallus)
Pi [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Gallus gallus)
Pi [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Gallus gallus)
Pi [cytosol]
Metabolism of amino acids and derivatives (Gallus gallus)
Glutamate and glutamine metabolism (Gallus gallus)
N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Gallus gallus)
Pi [cytosol]
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Gallus gallus)
Pi [cytosol]
Histidine catabolism (Gallus gallus)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Gallus gallus)
Pi [cytosol]
Selenoamino acid metabolism (Gallus gallus)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Gallus gallus)
SeMet is converted to AdoSeMet by MAT (Gallus gallus)
Pi [cytosol]
Serine metabolism (Gallus gallus)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Gallus gallus)
Pi [cytosol]
Sulfur amino acid metabolism (Gallus gallus)
MAT1A multimers transfer Ado from ATP to L-Met (Gallus gallus)
Pi [cytosol]
Methionine salvage pathway (Gallus gallus)
Acireductone is created (Gallus gallus)
Pi [cytosol]
MTA is cleaved and phosphorylated (Gallus gallus)
Pi [cytosol]
Metabolism of carbohydrates and carbohydrate derivatives (Gallus gallus)
Glucose metabolism (Gallus gallus)
Gluconeogenesis (Gallus gallus)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Gallus gallus)
Pi [cytosol]
GAPDH tetramers reduce 1,3BPG to GA3P (Gallus gallus)
Pi [cytosol]
SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Gallus gallus)
Pi [cytosol]
SLC7A4 exchanges G6P for Pi across the ER membrane (Gallus gallus)
Pi [cytosol]
Glycolysis (Gallus gallus)
GADPH tetramer dehydrogenates GA3P (Gallus gallus)
Pi [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Gallus gallus)
PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (Gallus gallus)
Pi [cytosol]
Glycogen metabolism (Gallus gallus)
Glycogen synthesis (Gallus gallus)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Gallus gallus)
Pi [cytosol]
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Gallus gallus)
Pi [cytosol]
Pentose phosphate pathway (Gallus gallus)
5-Phosphoribose 1-diphosphate biosynthesis (Gallus gallus)
PRPS dimers pyrophosphorylate R5P using ATP (Gallus gallus)
Pi [cytosol]
PRPS1 dimer pyrophosphorylates R5P using dATP (Gallus gallus)
Pi [cytosol]
Metabolism of lipids (Gallus gallus)
Fatty acid metabolism (Gallus gallus)
Arachidonate metabolism (Gallus gallus)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Gallus gallus)
LTC4 is exported from the cytosol by ABCC1 (Gallus gallus)
Pi [cytosol]
Carnitine shuttle (Gallus gallus)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Gallus gallus)
Pi [cytosol]
Fatty acyl-CoA biosynthesis (Gallus gallus)
ACLY tetramer transforms CIT to Ac-CoA (Gallus gallus)
Pi [cytosol]
Formation of Malonyl-CoA from Acetyl-CoA (liver) (Gallus gallus)
Pi [cytosol]
Metabolism of steroids (Gallus gallus)
Bile acid and bile salt metabolism (Gallus gallus)
Recycling of bile acids and salts (Gallus gallus)
ABCB11 transports bile salts from cytosol to extracellular region (Gallus gallus)
Pi [cytosol]
ABCC3 transports bile salts from cytosol to extracellular region (Gallus gallus)
Pi [cytosol]
Synthesis of bile acids and bile salts (Gallus gallus)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Gallus gallus)
ABCB11 transports bile salts from cytosol to extracellular region (Gallus gallus)
Pi [cytosol]
Cholesterol biosynthesis (Gallus gallus)
MVD decarboxylates MVA5PP to IPPP (Gallus gallus)
Pi [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Gallus gallus)
Pi [cytosol]
Phospholipid metabolism (Gallus gallus)
Glycerophospholipid biosynthesis (Gallus gallus)
PGP:Mg2+ dimer hydrolyses G3P to glycerol (Gallus gallus)
Pi [cytosol]
Synthesis of PC (Gallus gallus)
PA is dephosphorylated to DAG by LPIN (Gallus gallus)
Pi [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Gallus gallus)
Pi [cytosol]
Synthesis of PE (Gallus gallus)
PA is dephosphorylated to DAG by LPIN (Gallus gallus)
Pi [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Gallus gallus)
Pi [cytosol]
PI Metabolism (Gallus gallus)
Synthesis of PIPs at the ER membrane (Gallus gallus)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Gallus gallus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Gallus gallus)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Gallus gallus)
Pi [cytosol]
Synthesis of PIPs at the Golgi membrane (Gallus gallus)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Gallus gallus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Gallus gallus)
Pi [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Gallus gallus)
Pi [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Gallus gallus)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Gallus gallus)
Pi [cytosol]
Synthesis of PIPs at the early endosome membrane (Gallus gallus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Gallus gallus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Gallus gallus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Gallus gallus)
Pi [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Gallus gallus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Gallus gallus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Gallus gallus)
Pi [cytosol]
Synthesis of PIPs at the late endosome membrane (Gallus gallus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Gallus gallus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Gallus gallus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Gallus gallus)
Pi [cytosol]
Synthesis of PIPs at the plasma membrane (Gallus gallus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Gallus gallus)
Pi [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Gallus gallus)
Pi [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Gallus gallus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Gallus gallus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Gallus gallus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Gallus gallus)
Pi [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Gallus gallus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Gallus gallus)
Pi [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Gallus gallus)
Pi [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Gallus gallus)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Gallus gallus)
Pi [cytosol]
Sphingolipid metabolism (Gallus gallus)
Sphingolipid catabolism (Gallus gallus)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Gallus gallus)
Pi [cytosol]
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Gallus gallus)
Pi [cytosol]
Sphingolipid de novo biosynthesis (Gallus gallus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Gallus gallus)
Pi [cytosol]
Triglyceride metabolism (Gallus gallus)
Triglyceride biosynthesis (Gallus gallus)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Gallus gallus)
Pi [cytosol]
Metabolism of nucleotides (Gallus gallus)
Interconversion of nucleotide di- and triphosphates (Gallus gallus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Gallus gallus)
Pi [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Gallus gallus)
Pi [cytosol]
Nucleotide biosynthesis (Gallus gallus)
Purine ribonucleoside monophosphate biosynthesis (Gallus gallus)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Gallus gallus)
Pi [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Gallus gallus)
Pi [cytosol]
FGAM + ATP => AIR + ADP + Pi (Gallus gallus)
Pi [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Gallus gallus)
Pi [cytosol]
Nucleotide catabolism (Gallus gallus)
Purine catabolism (Gallus gallus)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Gallus gallus)
Pi [cytosol]
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Gallus gallus)
Pi [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Gallus gallus)
Pi [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Gallus gallus)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Gallus gallus)
Pi [cytosol]
Pyrimidine catabolism (Gallus gallus)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Gallus gallus)
Pi [cytosol]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Gallus gallus)
Pi [cytosol]
(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Gallus gallus)
Pi [cytosol]
Nucleotide salvage (Gallus gallus)
Pyrimidine salvage (Gallus gallus)
HDHD1:Mg2+ dephosphorylates PURIDP (Gallus gallus)
Pi [cytosol]
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Gallus gallus)
Pi [cytosol]
Metabolism of porphyrins (Gallus gallus)
Heme degradation (Gallus gallus)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Gallus gallus)
Pi [cytosol]
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of water-soluble vitamins and cofactors (Gallus gallus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Gallus gallus)
Transport of RCbl within the body (Gallus gallus)
ABCC1 transports cytosolic RCbl to extracellular region (Gallus gallus)
Pi [cytosol]
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Gallus gallus)
Pi [cytosol]
Uptake of dietary cobalamins into enterocytes (Gallus gallus)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Gallus gallus)
Pi [cytosol]
Metabolism of folate and pterines (Gallus gallus)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Gallus gallus)
Pi [cytosol]
FPGS-2 transforms THF to THFPG (Gallus gallus)
Pi [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Gallus gallus)
Pi [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Gallus gallus)
Pi [cytosol]
Nicotinate metabolism (Gallus gallus)
Nicotinamide salvage (Gallus gallus)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Gallus gallus)
Pi [cytosol]
Vitamin B2 (riboflavin) metabolism (Gallus gallus)
2xTRAP hydrolyzes FMN to RIB (Gallus gallus)
Pi [cytosol]
Vitamin B5 (pantothenate) metabolism (Gallus gallus)
PANK4 hydrolyzes PPANT to pantetheine (Gallus gallus)
Pi [cytosol]
Pyrophosphate hydrolysis (Gallus gallus)
LHPP:Mg2+ dimer hydrolyses PPi (Gallus gallus)
Pi [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Gallus gallus)
Pi [cytosol]
Metabolism of RNA (Gallus gallus)
Deadenylation-dependent mRNA decay (Gallus gallus)
mRNA decay by 3' to 5' exoribonuclease (Gallus gallus)
NT5C3B hydrolyses 7MGP to 7MG (Gallus gallus)
Pi [cytosol]
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Asparagine N-linked glycosylation (Gallus gallus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Gallus gallus)
Synthesis of substrates in N-glycan biosythesis (Gallus gallus)
Sialic acid metabolism (Gallus gallus)
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Gallus gallus)
Pi [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Gallus gallus)
Pi [cytosol]
Synthesis of dolichyl-phosphate (Gallus gallus)
DOLPP1 dephosphorylates DOLDP to DOLP (Gallus gallus)
Pi [cytosol]
MVD decarboxylates MVA5PP to IPPP (Gallus gallus)
Pi [cytosol]
Transport to the Golgi and subsequent modification (Gallus gallus)
ER to Golgi Anterograde Transport (Gallus gallus)
COPI-mediated anterograde transport (Gallus gallus)
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Gallus gallus)
Pi [cytosol]
COPII-mediated vesicle transport (Gallus gallus)
Loss of SAR1B GTPase (Gallus gallus)
Pi [cytosol]
NSF ATPase activity dissociates cis-SNARE (Gallus gallus)
Pi [cytosol]
PP6 dephosphorylates SEC24 (Gallus gallus)
Pi [cytosol]
Vesicle budding (Gallus gallus)
Pi [cytosol]
Protein folding (Gallus gallus)
Chaperonin-mediated protein folding (Gallus gallus)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Gallus gallus)
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Gallus gallus)
Pi [cytosol]
Surfactant metabolism (Gallus gallus)
ABCA3 transports PC, PG from ER membrane to lamellar body (Gallus gallus)
Pi [cytosol]
SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Gallus gallus)
Pi [cytosol]
Translation (Gallus gallus)
Eukaryotic Translation Initiation (Gallus gallus)
Cap-dependent Translation Initiation (Gallus gallus)
GTP hydrolysis and joining of the 60S ribosomal subunit (Gallus gallus)
eIF5B:GTP is hydrolyzed and released (Gallus gallus)
Pi [cytosol]
Ribosomal scanning and start codon recognition (Gallus gallus)
Ribosomal scanning (Gallus gallus)
Pi [cytosol]
tRNA Aminoacylation (Gallus gallus)
Cytosolic tRNA aminoacylation (Gallus gallus)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Gallus gallus)
Pi [cytosol]
Muscle contraction (Gallus gallus)
Cardiac conduction (Gallus gallus)
Ion homeostasis (Gallus gallus)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Gallus gallus)
Pi [cytosol]
Smooth Muscle Contraction (Gallus gallus)
ATP Hydrolysis By Myosin (Gallus gallus)
Pi [cytosol]
Striated Muscle Contraction (Gallus gallus)
ATP Hydrolysis By Myosin (Gallus gallus)
Pi [cytosol]
Neuronal System (Gallus gallus)
Transmission across Chemical Synapses (Gallus gallus)
Neurotransmitter receptors and postsynaptic signal transmission (Gallus gallus)
GABA receptor activation (Gallus gallus)
GABA B receptor activation (Gallus gallus)
Activation of GABAB receptors (Gallus gallus)
Adenylate cyclase inhibitory pathway (Gallus gallus)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Gallus gallus)
Pi [cytosol]
Adenylate cyclase increases the GTPase activity of Gi alpha (Gallus gallus)
Pi [cytosol]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Gallus gallus)
Trafficking of AMPA receptors (Gallus gallus)
Trafficking of GluR2-containing AMPA receptors (Gallus gallus)
Endocytosis of Ca impermeable AMPA receptors (Gallus gallus)
Pi [cytosol]
Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Gallus gallus)
Pi [cytosol]
Trafficking of GluR2-containing AMPA receptors to synapse (Gallus gallus)
Pi [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Gallus gallus)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Gallus gallus)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Gallus gallus)
Pi [cytosol]
Organelle biogenesis and maintenance (Gallus gallus)
Cilium Assembly (Gallus gallus)
Cargo trafficking to the periciliary membrane (Gallus gallus)
VxPx cargo-targeting to cilium (Gallus gallus)
ASAP1 stimulates GTPase activity of ARF4 (Gallus gallus)
Pi [cytosol]
Sensory Perception (Gallus gallus)
Visual phototransduction (Gallus gallus)
The canonical retinoid cycle in rods (twilight vision) (Gallus gallus)
ABCA4 mediates atRAL transport (Gallus gallus)
Pi [cytosol]
The phototransduction cascade (Gallus gallus)
Inactivation, recovery and regulation of the phototransduction cascade (Gallus gallus)
PP2A dephosphorylates p-RHO to RHO (Gallus gallus)
Pi [cytosol]
Signal Transduction (Gallus gallus)
Integrin signaling (Gallus gallus)
Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)
Pi [cytosol]
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
Negative regulation of the PI3K/AKT network (Gallus gallus)
PHLPP dephosphorylates S473 in AKT (Gallus gallus)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Gallus gallus)
Pi [cytosol]
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF-independent MAPK1/3 activation (Gallus gallus)
Cytosolic DUSPs dephosphorylate MAPKs (Gallus gallus)
Pi [cytosol]
RAF/MAP kinase cascade (Gallus gallus)
Negative regulation of MAPK pathway (Gallus gallus)
Cytosolic DUSPs dephosphorylate MAPKs (Gallus gallus)
Pi [cytosol]
PTPN3 dephosphorylates MAPK12 (Gallus gallus)
Pi [cytosol]
RAF activation (Gallus gallus)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Gallus gallus)
Pi [cytosol]
MTOR signalling (Gallus gallus)
Energy dependent regulation of mTOR by LKB1-AMPK (Gallus gallus)
AMPK is dephosphorylated (Gallus gallus)
Pi [cytosol]
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Gallus gallus)
Pi [cytosol]
Signaling by GPCR (Gallus gallus)
GPCR downstream signalling (Gallus gallus)
G alpha (i) signalling events (Gallus gallus)
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Gallus gallus)
Pi [cytosol]
Opioid Signalling (Gallus gallus)
G-protein mediated events (Gallus gallus)
Adenylate cyclase activating pathway (Gallus gallus)
Adenylaye cyclase increases the GTPase activity of G alpha-olf (Gallus gallus)
Pi [cytosol]
Adenylate cyclase inhibitory pathway (Gallus gallus)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Gallus gallus)
Pi [cytosol]
Adenylate cyclase increases the GTPase activity of Gi alpha (Gallus gallus)
Pi [cytosol]
PLC beta mediated events (Gallus gallus)
Inactivation of PLC beta (Gallus gallus)
Pi [cytosol]
G alpha (q) signalling events (Gallus gallus)
G alpha (q) in G (q):RGS complex is inactivated (Gallus gallus)
Pi [cytosol]
G alpha (z) signalling events (Gallus gallus)
G alpha (z) in G alpha (z):RGS complex is inactivated (Gallus gallus)
Pi [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Gallus gallus)
Signaling by PTK6 (Gallus gallus)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Gallus gallus)
ARHGAP35 stimulates RHOA GTPase activity (Gallus gallus)
Pi [cytosol]
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ALK (Gallus gallus)
MDK and PTN in ALK signaling (Gallus gallus)
PTPRZ dephosphorylates ligand-bound ALK dimers (Gallus gallus)
Pi [cytosol]
Signaling by EGFR (Gallus gallus)
EGFR downregulation (Gallus gallus)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Gallus gallus)
Pi [cytosol]
PTPN3 dephosphorylates EPS15 (Gallus gallus)
Pi [cytosol]
GAB1 signalosome (Gallus gallus)
Dephosphorylation of Gab1 by SHP2 (Gallus gallus)
Pi [cytosol]
Dephosphorylation of PAG by SHP2 (Gallus gallus)
Pi [cytosol]
SHP2 dephosphorylates Tyr 992 on EGFR (Gallus gallus)
Pi [cytosol]
Sustained activation of SRC kinase by SHP2 (Gallus gallus)
Pi [cytosol]
Signaling by ERBB2 (Gallus gallus)
Downregulation of ERBB2 signaling (Gallus gallus)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Gallus gallus)
Pi [cytosol]
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Gallus gallus)
Pi [cytosol]
Signaling by Insulin receptor (Gallus gallus)
Insulin receptor recycling (Gallus gallus)
Insulin receptor de-phosphorylation (Gallus gallus)
Pi [cytosol]
Signaling by MET (Gallus gallus)
Negative regulation of MET activity (Gallus gallus)
PTPN1 and PTPN2 dephosphorylate MET (Gallus gallus)
Pi [cytosol]
PTPRJ dephosphorylates MET (Gallus gallus)
Pi [cytosol]
Signaling by PDGF (Gallus gallus)
PTPN12 dephosphorylates PDGFRB at Y1021 (Gallus gallus)
Pi [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Gallus gallus)
Miro GTPase Cycle (Gallus gallus)
RHOT1 GTPase cycle (Gallus gallus)
RHOT1 hydrolyzes GTP (Gallus gallus)
Pi [cytosol]
RHOT2 GTPase cycle (Gallus gallus)
RHOT2 hydrolyzes GTP (Gallus gallus)
Pi [cytosol]
RHOBTB3 ATPase cycle (Gallus gallus)
RHOBTB3 hydrolyzes ATP (Gallus gallus)
Pi [cytosol]
Signaling by Rho GTPases (Gallus gallus)
RHO GTPase cycle (Gallus gallus)
CDC42 GTPase cycle (Gallus gallus)
CDC42 GAPs stimulate CDC42 GTPase activity (Gallus gallus)
Pi [cytosol]
RAC1 GTPase cycle (Gallus gallus)
RAC1 GAPs stimulate RAC1 GTPase activity (Gallus gallus)
Pi [cytosol]
RAC2 GTPase cycle (Gallus gallus)
RAC2 GAPs stimulate RAC2 GTPase activity (Gallus gallus)
Pi [cytosol]
RAC3 GTPase cycle (Gallus gallus)
RAC3 GAPs stimulate RAC3 GTPase activity (Gallus gallus)
Pi [cytosol]
RHOA GTPase cycle (Gallus gallus)
RHOA GAPs stimulate RHOA GTPase activity (Gallus gallus)
Pi [cytosol]
RHOB GTPase cycle (Gallus gallus)
RHOB GAPs stimulate RHOB GTPase activity (Gallus gallus)
Pi [cytosol]
RHOC GTPase cycle (Gallus gallus)
RHOC GAPs stimulate RHOC GTPase activity (Gallus gallus)
Pi [cytosol]
RHOD GTPase cycle (Gallus gallus)
RHOD GAPs stimulate RHOD GTPase activity (Gallus gallus)
Pi [cytosol]
RHOF GTPase cycle (Gallus gallus)
RHOF GAPs stimulate RHOF GTPase activity (Gallus gallus)
Pi [cytosol]
RHOG GTPase cycle (Gallus gallus)
RHOG GAPs stimulate RHOG GTPase activity (Gallus gallus)
Pi [cytosol]
RHOJ GTPase cycle (Gallus gallus)
RHOJ GAPs stimulate RHOJ GTPase activity (Gallus gallus)
Pi [cytosol]
RHOQ GTPase cycle (Gallus gallus)
RHOQ GAPs stimulate RHOQ GTPase activity (Gallus gallus)
Pi [cytosol]
Signaling by TGFB family members (Gallus gallus)
Signaling by TGF-beta Receptor Complex (Gallus gallus)
TGF-beta receptor signaling activates SMADs (Gallus gallus)
Downregulation of TGF-beta receptor signaling (Gallus gallus)
MTMR4 dephosphorylates SMAD2/3 (Gallus gallus)
Pi [cytosol]
Signaling by WNT (Gallus gallus)
Beta-catenin independent WNT signaling (Gallus gallus)
Ca2+ pathway (Gallus gallus)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Gallus gallus)
Pi [cytosol]
Transport of small molecules (Gallus gallus)
ABC-family proteins mediated transport (Gallus gallus)
ABC transporters in lipid homeostasis (Gallus gallus)
ABCA12 transports lipids from cytosol to extracellular region (Gallus gallus)
Pi [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Gallus gallus)
Pi [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Gallus gallus)
Pi [cytosol]
ABCAs mediate lipid efflux (Gallus gallus)
Pi [cytosol]
ABCAs mediate lipid influx (Gallus gallus)
Pi [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Gallus gallus)
Pi [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Gallus gallus)
Pi [cytosol]
ABCG4 may mediate cholesterol efflux (Gallus gallus)
Pi [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Gallus gallus)
Pi [cytosol]
ABCA4 mediates atRAL transport (Gallus gallus)
Pi [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Gallus gallus)
Pi [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Gallus gallus)
Pi [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Gallus gallus)
Pi [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Gallus gallus)
Pi [cytosol]
HCO3- transport through ion channel (Gallus gallus)
Pi [cytosol]
Mitochondrial ABC transporters (Gallus gallus)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Gallus gallus)
Pi [cytosol]
The ABCC family mediates organic anion transport (Gallus gallus)
Pi [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Gallus gallus)
Pi [cytosol]
Ion channel transport (Gallus gallus)
Ion transport by P-type ATPases (Gallus gallus)
ATP12A:ATP4B exchanges K+ for H+ (Gallus gallus)
Pi [cytosol]
ATP13A1 transports Mn2+ from cytosol to ER lumen (Gallus gallus)
Pi [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Gallus gallus)
Pi [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Gallus gallus)
Pi [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Gallus gallus)
Pi [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Gallus gallus)
Pi [cytosol]
ATP7A transports cytosolic Cu2+ to extracellular region (Gallus gallus)
Pi [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Gallus gallus)
Pi [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Gallus gallus)
Pi [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Gallus gallus)
Pi [cytosol]
Iron uptake and transport (Gallus gallus)
Transferrin endocytosis and recycling (Gallus gallus)
Acidification of Tf:TfR1 containing endosome (Gallus gallus)
Pi [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Gallus gallus)
Plasma lipoprotein assembly (Gallus gallus)
HDL assembly (Gallus gallus)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Gallus gallus)
Pi [cytosol]
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Gallus gallus)
Pi [cytosol]
Plasma lipoprotein remodeling (Gallus gallus)
HDL remodeling (Gallus gallus)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Gallus gallus)
Pi [cytosol]
SLC-mediated transmembrane transport (Gallus gallus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Gallus gallus)
Organic anion transporters (Gallus gallus)
SLC25A10 mediates exchange of malate and phosphate (Gallus gallus)
Pi [cytosol]
Sodium-coupled phosphate cotransporters (Gallus gallus)
SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Gallus gallus)
Pi [cytosol]
Type II Na+/Pi cotransporters (Gallus gallus)
SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Gallus gallus)
Pi [cytosol]
Vesicle-mediated transport (Gallus gallus)
Membrane Trafficking (Gallus gallus)
Clathrin-mediated endocytosis (Gallus gallus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)
Pi [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)
Pi [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)
Pi [cytosol]
ER to Golgi Anterograde Transport (Gallus gallus)
COPI-mediated anterograde transport (Gallus gallus)
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Gallus gallus)
Pi [cytosol]
COPII-mediated vesicle transport (Gallus gallus)
Loss of SAR1B GTPase (Gallus gallus)
Pi [cytosol]
NSF ATPase activity dissociates cis-SNARE (Gallus gallus)
Pi [cytosol]
PP6 dephosphorylates SEC24 (Gallus gallus)
Pi [cytosol]
Vesicle budding (Gallus gallus)
Pi [cytosol]
Endosomal Sorting Complex Required For Transport (ESCRT) (Gallus gallus)
ESCRT Disassembly (Gallus gallus)
Pi [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Gallus gallus)
Golgi-to-ER retrograde transport (Gallus gallus)
COPI-dependent Golgi-to-ER retrograde traffic (Gallus gallus)
NSF ATPase activity dissociates cis-SNARE at the ER (Gallus gallus)
Pi [cytosol]
Rab regulation of trafficking (Gallus gallus)
TBC/RABGAPs (Gallus gallus)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Gallus gallus)
Pi [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Gallus gallus)
Pi [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Gallus gallus)
Pi [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Gallus gallus)
Pi [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Gallus gallus)
Pi [cytosol]
trans-Golgi Network Vesicle Budding (Gallus gallus)
Golgi Associated Vesicle Biogenesis (Gallus gallus)
trans-Golgi Network Coat Assembly (Gallus gallus)
Pi [cytosol]
trans-Golgi Network Vesicle Scission (Gallus gallus)
Pi [cytosol]
Lysosome Vesicle Biogenesis (Gallus gallus)
trans-Golgi Network Lysosomal Vesicle Scission (Gallus gallus)
Pi [cytosol]
trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Gallus gallus)
Pi [cytosol]
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
ULK1 is dephosphorylated (Homo sapiens)
Pi [cytosol]
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Nuclear Envelope (NE) Reassembly (Homo sapiens)
Initiation of Nuclear Envelope (NE) Reformation (Homo sapiens)
PP2A dephosphorylates BANF1 (Homo sapiens)
Pi [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Homo sapiens)
RAN stimulates fusion of nuclear envelope (NE) membranes (Homo sapiens)
Pi [cytosol]
Sealing of the nuclear envelope (NE) by ESCRT-III (Homo sapiens)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Homo sapiens)
Pi [cytosol]
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
Pi [cytosol]
Mitotic Prometaphase (Homo sapiens)
Condensation of Prometaphase Chromosomes (Homo sapiens)
Dephosphorylation of CK2-modified condensin I (Homo sapiens)
Pi [cytosol]
Resolution of Sister Chromatid Cohesion (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
Pi [cytosol]
PPP1CC dephosphorylates PLK1 (Homo sapiens)
Pi [cytosol]
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Cyclin A/B1/B2 associated events during G2/M transition (Homo sapiens)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Homo sapiens)
Pi [cytosol]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Homo sapiens)
PP2A dephosphorylates serine-127 of YAP1 (Homo sapiens)
Pi [cytosol]
PP2A dephosphorylates serine-715 of PDE4D5 in p-S715-PDE4D5:integrin alpha5:integrin beta1:fibronectin (Homo sapiens)
Pi [cytosol]
PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) (Homo sapiens)
Pi [cytosol]
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
ATP7A transfers Cu from ATOX1 to SOD3 (Homo sapiens)
Pi [cytosol]
Cellular response to heat stress (Homo sapiens)
Regulation of HSF1-mediated heat shock response (Homo sapiens)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Homo sapiens)
Pi [cytosol]
Cellular response to starvation (Homo sapiens)
Amino acids regulate mTORC1 (Homo sapiens)
RRAGA,B hydrolyzes GTP (Homo sapiens)
Pi [cytosol]
RRAGC,D hydrolyzes GTP (Homo sapiens)
Pi [cytosol]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Homo sapiens)
ATP hydrolysis by HSP70 (Homo sapiens)
Pi [cytosol]
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Homo sapiens)
Pi [cytosol]
L1CAM interactions (Homo sapiens)
Recycling pathway of L1 (Homo sapiens)
Dephosphorylation of pL1 (Y1176) (Homo sapiens)
Pi [cytosol]
Formation of clathrin coated vesicle (Homo sapiens)
Pi [cytosol]
NCAM signaling for neurite out-growth (Homo sapiens)
Dephosphorylation of NCAM1 bound pFyn (Homo sapiens)
Pi [cytosol]
Semaphorin interactions (Homo sapiens)
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (Homo sapiens)
Inactivation of R-Ras by Sema3A-Plexin-A GAP activity (Homo sapiens)
Pi [cytosol]
Sema4D in semaphorin signaling (Homo sapiens)
Sema4D mediated inhibition of cell attachment and migration (Homo sapiens)
Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Homo sapiens)
Pi [cytosol]
Inactivation of Rho-GTP by p190RhoGAP (Homo sapiens)
Pi [cytosol]
Signaling by ROBO receptors (Homo sapiens)
Inactivation of CDC42 and RAC1 (Homo sapiens)
Inactivation of CDC42 (Homo sapiens)
Pi [cytosol]
Inactivation of RAC1 (Homo sapiens)
Pi [cytosol]
SLIT2:ROBO1 increases RHOA activity (Homo sapiens)
MYO9B inactivates RHOA (Homo sapiens)
Pi [cytosol]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of nucleotide metabolism (Homo sapiens)
Nucleotide catabolism defects (Homo sapiens)
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine (Homo sapiens)
Defective PNP does not convert (deoxy)guanosine to guanine and (deoxy)ribose (Homo sapiens)
Pi [cytosol]
Defective PNP does not convert (deoxy)inosine to hypoxanthine and (deoxy)ribose (Homo sapiens)
Pi [cytosol]
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Signaling by MRAS-complex mutants (Homo sapiens)
Gain-of-function MRAS complexes activate RAF signaling (Homo sapiens)
Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs (Homo sapiens)
Pi [cytosol]
Disorders of transmembrane transporters (Homo sapiens)
ABC transporter disorders (Homo sapiens)
Defective CFTR causes cystic fibrosis (Homo sapiens)
Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region (Homo sapiens)
Pi [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol (Homo sapiens)
Pi [cytosol]
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Infection with Mycobacterium tuberculosis (Homo sapiens)
Response of Mtb to phagocytosis (Homo sapiens)
Suppression of apoptosis (Homo sapiens)
PtpA dephosphorylates GSK3A (Homo sapiens)
Pi [cytosol]
Suppression of phagosomal maturation (Homo sapiens)
Prevention of phagosomal-lysosomal fusion (Homo sapiens)
NdkA dephosphorylates RAB5A:GTP,RAB7A:GTP (Homo sapiens)
Pi [cytosol]
PtpA:Ub dephosphorylates p-Y133-VPS33B (Homo sapiens)
Pi [cytosol]
SapM dephosphorylates PI3P (Homo sapiens)
Pi [cytosol]
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
Extension of pseudopodia by myosin-X in a PI3K dependent manner (Homo sapiens)
Pi [cytosol]
IgG:Leishmania surface:FCGR3A translocates from plasma membrane to the parasitophorous vacuole (Homo sapiens)
Pi [cytosol]
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Rev-mediated nuclear export of HIV RNA (Homo sapiens)
Hydrolysis of Ran:GTP to Ran:GDP (Homo sapiens)
Pi [cytosol]
Host Interactions of HIV factors (Homo sapiens)
Interactions of Rev with host cellular proteins (Homo sapiens)
Rev-mediated nuclear export of HIV RNA (Homo sapiens)
Hydrolysis of Ran:GTP to Ran:GDP (Homo sapiens)
Pi [cytosol]
Influenza Infection (Homo sapiens)
Export of Viral Ribonucleoproteins from Nucleus (Homo sapiens)
NEP/NS2 Interacts with the Cellular Export Machinery (Homo sapiens)
vRNP Export through the nuclear pore (Homo sapiens)
Pi [cytosol]
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
Respiratory syncytial virus (RSV) genome replication, transcription and translation (Homo sapiens)
Maturation of hRSV A proteins (Homo sapiens)
P:PP1 dephosphorylates M2-1 (Homo sapiens)
Pi [cytosol]
Respiratory syncytial virus genome transcription (Homo sapiens)
L protein acts as a cap N7 methyltransferase to modify RSV mRNAs (Homo sapiens)
Pi [cytosol]
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1 Genome Replication and Transcription (Homo sapiens)
Replication of the SARS-CoV-1 genome (Homo sapiens)
nsp13 helicase melts secondary structures in SARS-CoV-1 genomic RNA template (Homo sapiens)
Pi [cytosol]
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand) (Homo sapiens)
Pi [cytosol]
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) (Homo sapiens)
Pi [cytosol]
Transcription of SARS-CoV-1 sgRNAs (Homo sapiens)
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs (Homo sapiens)
Pi [cytosol]
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
SARS-CoV-2 Genome Replication and Transcription (Homo sapiens)
Replication of the SARS-CoV-2 genome (Homo sapiens)
nsp13 helicase melts secondary structures in SARS-CoV-2 genomic RNA template (Homo sapiens)
Pi [cytosol]
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand) (Homo sapiens)
Pi [cytosol]
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand) (Homo sapiens)
Pi [cytosol]
Transcription of SARS-CoV-2 sgRNAs (Homo sapiens)
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs (Homo sapiens)
Pi [cytosol]
Drug ADME (Homo sapiens)
Abacavir ADME (Homo sapiens)
Abacavir transmembrane transport (Homo sapiens)
abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate (Homo sapiens)
Pi [cytosol]
Aspirin ADME (Homo sapiens)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Homo sapiens)
Pi [cytosol]
Azathioprine ADME (Homo sapiens)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Homo sapiens)
Pi [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Homo sapiens)
Pi [cytosol]
Paracetamol ADME (Homo sapiens)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Homo sapiens)
Pi [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Homo sapiens)
Pi [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Homo sapiens)
Pi [cytosol]
Prednisone ADME (Homo sapiens)
ABCB1 transports PREDN,PREDL out of hepatic cells (Homo sapiens)
Pi [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Homo sapiens)
Pi [cytosol]
ABCB1 transports xenobiotics out of the cell (Homo sapiens)
Pi [cytosol]
Gene expression (Transcription) (Homo sapiens)
Gene Silencing by RNA (Homo sapiens)
MicroRNA (miRNA) biogenesis (Homo sapiens)
Exportin complex translocates pre-miRNA to cytosol (Homo sapiens)
Pi [cytosol]
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Homo sapiens)
Pi [cytosol]
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Homo sapiens)
Pi [cytosol]
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
Pi [cytosol]
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
ABCC4 accumulation of dense granule contents (Homo sapiens)
Pi [cytosol]
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Homo sapiens)
Transport of Antigen peptide in to ER (Homo sapiens)
Pi [cytosol]
Antigen processing-Cross presentation (Homo sapiens)
ER-Phagosome pathway (Homo sapiens)
Translocation of antigenic peptides back to phagosomes via TAP (Homo sapiens)
Pi [cytosol]
MHC class II antigen presentation (Homo sapiens)
Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Homo sapiens)
Pi [cytosol]
Internalization of MHC II:Ii clathrin coated vesicle (Homo sapiens)
Pi [cytosol]
Translocation of TGN-lysosome vesicle to lysosome (Homo sapiens)
Pi [cytosol]
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-inhibition by CTLA4 (Homo sapiens)
Dephosphorylation of AKT by PP2A (Homo sapiens)
Pi [cytosol]
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
Hydrolysis of PIP3 to PI(3,4)P2 (Homo sapiens)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Homo sapiens)
Pi [cytosol]
Phosphorylation of CD3 and TCR zeta chains (Homo sapiens)
Dephosphorylation of Lck-pY505 by CD45 (Homo sapiens)
Pi [cytosol]
Inactivation of LCK by PTPN22 (Homo sapiens)
Pi [cytosol]
Translocation of ZAP-70 to Immunological synapse (Homo sapiens)
PTPN22 dephosphorylates ZAP70 (Homo sapiens)
Pi [cytosol]
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
Negative regulation of FLT3 (Homo sapiens)
PTPRJ dephosphorylates active FLT3 (Homo sapiens)
Pi [cytosol]
Growth hormone receptor signaling (Homo sapiens)
PTP1B dephosphorylates GHR (Homo sapiens)
Pi [cytosol]
PTP1B dephosphorylates JAK2 (Homo sapiens)
Pi [cytosol]
SHP1 (PTPN6) dephosphorylates JAK2 (Homo sapiens)
Pi [cytosol]
Interferon Signaling (Homo sapiens)
Interferon alpha/beta signaling (Homo sapiens)
Regulation of IFNA/IFNB signaling (Homo sapiens)
Dephosphorylation of JAK1 by SHP1 (Homo sapiens)
Pi [cytosol]
Dephosphorylation of STAT1 by SHP2 (Homo sapiens)
Pi [cytosol]
Dephosphorylation of TYK2 by PTP1B (Homo sapiens)
Pi [cytosol]
Interferon gamma signaling (Homo sapiens)
Regulation of IFNG signaling (Homo sapiens)
Dephosphorylation of JAKs by PTPs (Homo sapiens)
Pi [cytosol]
Signaling by CSF3 (G-CSF) (Homo sapiens)
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Homo sapiens)
Pi [cytosol]
Innate Immune System (Homo sapiens)
Antimicrobial peptides (Homo sapiens)
Ion influx/efflux at host-pathogen interface (Homo sapiens)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Homo sapiens)
Pi [cytosol]
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
CLEC7A (Dectin-1) induces NFAT activation (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT (Homo sapiens)
Pi [cytosol]
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT (Homo sapiens)
Pi [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
Extension of pseudopodia by myosin-X in a PI3K dependent manner (Homo sapiens)
Pi [cytosol]
Role of myosins in phagosome formation (Homo sapiens)
Pi [cytosol]
Role of phospholipids in phagocytosis (Homo sapiens)
Conversion of PA into DAG by PAP-1 (Homo sapiens)
Pi [cytosol]
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Pyruvate metabolism (Homo sapiens)
Regulation of pyruvate metabolism (Homo sapiens)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Homo sapiens)
Pi [cytosol]
Biological oxidations (Homo sapiens)
Phase II - Conjugation of compounds (Homo sapiens)
Cytosolic sulfonation of small molecules (Homo sapiens)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Homo sapiens)
Pi [cytosol]
Glutathione conjugation (Homo sapiens)
Glutathione synthesis and recycling (Homo sapiens)
GCL ligates L-Glu to L-Cys (Homo sapiens)
Pi [cytosol]
GSS:Mg2+ dimer synthesizes GSH (Homo sapiens)
Pi [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Homo sapiens)
Pi [cytosol]
Methylation (Homo sapiens)
MAT1A multimers transfer Ado from ATP to L-Met (Homo sapiens)
Pi [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Homo sapiens)
Pi [cytosol]
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP2, IP, and Ins in the cytosol (Homo sapiens)
I(1,3)P2 is dephosphorylated into I1P by MTMR7 (Homo sapiens)
Pi [cytosol]
I(1,3)P2 is dephosphorylated into I1P by MTMR7:MTMR9 (Homo sapiens)
Pi [cytosol]
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Homo sapiens)
Pi [cytosol]
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Homo sapiens)
Pi [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Homo sapiens)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Homo sapiens)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Homo sapiens)
Pi [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Homo sapiens)
Pi [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)
Pi [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)
Pi [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)
Pi [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Homo sapiens)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Homo sapiens)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Homo sapiens)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Homo sapiens)
Pi [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Homo sapiens)
Pi [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Homo sapiens)
Pi [cytosol]
Synthesis of pyrophosphates in the cytosol (Homo sapiens)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Homo sapiens)
Pi [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Homo sapiens)
Pi [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Homo sapiens)
Pi [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Homo sapiens)
Pi [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Homo sapiens)
Pi [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Homo sapiens)
Pi [cytosol]
Integration of energy metabolism (Homo sapiens)
PP2A-mediated dephosphorylation of key metabolic factors (Homo sapiens)
Dephosphorylation of pChREBP (Ser 196) by PP2A (Homo sapiens)
Pi [cytosol]
PP2A complex dephosphorylates p-PFKFB1 (Homo sapiens)
Pi [cytosol]
Metabolism of amino acids and derivatives (Homo sapiens)
Creatine metabolism (Homo sapiens)
phosphocreatine + H2O => creatinine + orthophosphate (Homo sapiens)
Pi [cytosol]
Glutamate and glutamine metabolism (Homo sapiens)
N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Homo sapiens)
Pi [cytosol]
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Homo sapiens)
Pi [cytosol]
Histidine catabolism (Homo sapiens)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Homo sapiens)
Pi [cytosol]
Selenoamino acid metabolism (Homo sapiens)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Homo sapiens)
SeMet is converted to AdoSeMet by MAT (Homo sapiens)
Pi [cytosol]
Selenocysteine synthesis (Homo sapiens)
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC (Homo sapiens)
Pi [cytosol]
SEPHS2 phosphorylates H2Se to form SELP (Homo sapiens)
Pi [cytosol]
Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer (Homo sapiens)
Pi [cytosol]
Serine metabolism (Homo sapiens)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Homo sapiens)
Pi [cytosol]
Sulfur amino acid metabolism (Homo sapiens)
MAT1A multimers transfer Ado from ATP to L-Met (Homo sapiens)
Pi [cytosol]
Methionine salvage pathway (Homo sapiens)
Acireductone is created (Homo sapiens)
Pi [cytosol]
MTA is cleaved and phosphorylated (Homo sapiens)
Pi [cytosol]
Metabolism of carbohydrates and carbohydrate derivatives (Homo sapiens)
Glucose metabolism (Homo sapiens)
Gluconeogenesis (Homo sapiens)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Homo sapiens)
Pi [cytosol]
GAPDH tetramers reduce 1,3BPG to GA3P (Homo sapiens)
Pi [cytosol]
SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Homo sapiens)
Pi [cytosol]
SLC7A4 exchanges G6P for Pi across the ER membrane (Homo sapiens)
Pi [cytosol]
Glycolysis (Homo sapiens)
GADPH tetramer dehydrogenates GA3P (Homo sapiens)
Pi [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Homo sapiens)
PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (Homo sapiens)
Pi [cytosol]
PP2A complex dephosphorylates p-PFKFB1 (Homo sapiens)
Pi [cytosol]
Glycogen metabolism (Homo sapiens)
Glycogen breakdown (glycogenolysis) (Homo sapiens)
glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] (Homo sapiens)
Pi [cytosol]
glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Homo sapiens)
Pi [cytosol]
poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Homo sapiens)
Pi [cytosol]
poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] (Homo sapiens)
Pi [cytosol]
Glycogen synthesis (Homo sapiens)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Homo sapiens)
Pi [cytosol]
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Homo sapiens)
Pi [cytosol]
Pentose phosphate pathway (Homo sapiens)
5-Phosphoribose 1-diphosphate biosynthesis (Homo sapiens)
PRPS dimers pyrophosphorylate R5P using ATP (Homo sapiens)
Pi [cytosol]
PRPS1 dimer pyrophosphorylates R5P using dATP (Homo sapiens)
Pi [cytosol]
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonate metabolism (Homo sapiens)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Homo sapiens)
LTC4 is exported from the cytosol by ABCC1 (Homo sapiens)
Pi [cytosol]
Carnitine shuttle (Homo sapiens)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Homo sapiens)
Pi [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Homo sapiens)
Pi [cytosol]
Fatty acyl-CoA biosynthesis (Homo sapiens)
ACLY tetramer transforms CIT to Ac-CoA (Homo sapiens)
Pi [cytosol]
Formation of Malonyl-CoA from Acetyl-CoA (liver) (Homo sapiens)
Pi [cytosol]
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Recycling of bile acids and salts (Homo sapiens)
ABCB11 transports bile salts from cytosol to extracellular region (Homo sapiens)
Pi [cytosol]
ABCC3 transports bile salts from cytosol to extracellular region (Homo sapiens)
Pi [cytosol]
Synthesis of bile acids and bile salts (Homo sapiens)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
ABCB11 transports bile salts from cytosol to extracellular region (Homo sapiens)
Pi [cytosol]
Cholesterol biosynthesis (Homo sapiens)
MVD decarboxylates MVA5PP to IPPP (Homo sapiens)
Pi [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Homo sapiens)
Pi [cytosol]
Phospholipid metabolism (Homo sapiens)
Glycerophospholipid biosynthesis (Homo sapiens)
PGP:Mg2+ dimer hydrolyses G3P to glycerol (Homo sapiens)
Pi [cytosol]
Synthesis of PC (Homo sapiens)
PA is dephosphorylated to DAG by LPIN (Homo sapiens)
Pi [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Homo sapiens)
Pi [cytosol]
Synthesis of PE (Homo sapiens)
PA is dephosphorylated to DAG by LPIN (Homo sapiens)
Pi [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Homo sapiens)
Pi [cytosol]
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the ER membrane (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Homo sapiens)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Homo sapiens)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Homo sapiens)
Pi [cytosol]
Synthesis of PIPs at the Golgi membrane (Homo sapiens)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Homo sapiens)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Homo sapiens)
Pi [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Homo sapiens)
Pi [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Homo sapiens)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Homo sapiens)
Pi [cytosol]
Synthesis of PIPs at the early endosome membrane (Homo sapiens)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Homo sapiens)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Homo sapiens)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Homo sapiens)
Pi [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Homo sapiens)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Homo sapiens)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Homo sapiens)
Pi [cytosol]
Synthesis of PIPs at the late endosome membrane (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Homo sapiens)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Homo sapiens)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Homo sapiens)
Pi [cytosol]
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Homo sapiens)
Pi [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Homo sapiens)
Pi [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Homo sapiens)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Homo sapiens)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Homo sapiens)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Homo sapiens)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane (Homo sapiens)
Pi [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Homo sapiens)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Homo sapiens)
Pi [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Homo sapiens)
Pi [cytosol]
PI3P is dephosphorylated to PI by the MTMR2:SBF2 tetramer at the plasma membrane (Homo sapiens)
Pi [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Homo sapiens)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Homo sapiens)
Pi [cytosol]
Sphingolipid metabolism (Homo sapiens)
Sphingolipid catabolism (Homo sapiens)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Homo sapiens)
Pi [cytosol]
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Homo sapiens)
Pi [cytosol]
Sphingolipid de novo biosynthesis (Homo sapiens)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Homo sapiens)
Pi [cytosol]
PPM1L dephosphorylates multiphospho-CERT1-2 (Homo sapiens)
Pi [cytosol]
Triglyceride metabolism (Homo sapiens)
Triglyceride biosynthesis (Homo sapiens)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Homo sapiens)
Pi [cytosol]
Triglyceride catabolism (Homo sapiens)
phosphorylated HSL + H2O -> HSL + orthophosphate (Homo sapiens)
Pi [cytosol]
phosphorylated perilipin + H2O -> perilipin + orthophosphate (Homo sapiens)
Pi [cytosol]
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Homo sapiens)
Pi [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Homo sapiens)
Pi [cytosol]
Nucleotide biosynthesis (Homo sapiens)
Purine ribonucleoside monophosphate biosynthesis (Homo sapiens)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Homo sapiens)
Pi [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Homo sapiens)
Pi [cytosol]
FGAM + ATP => AIR + ADP + Pi (Homo sapiens)
Pi [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Homo sapiens)
Pi [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Homo sapiens)
Pi [cytosol]
Pyrimidine biosynthesis (Homo sapiens)
CAD hexamer transforms CAP to N-carb-L-Asp (Homo sapiens)
Pi [cytosol]
CAD hexamer transforms L-Gln to CAP (Homo sapiens)
Pi [cytosol]
Nucleotide catabolism (Homo sapiens)
Purine catabolism (Homo sapiens)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Homo sapiens)
Pi [cytosol]
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Homo sapiens)
Pi [cytosol]
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Homo sapiens)
Pi [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Homo sapiens)
Pi [cytosol]
PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Homo sapiens)
Pi [cytosol]
PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Homo sapiens)
Pi [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Homo sapiens)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Homo sapiens)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Homo sapiens)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Homo sapiens)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Homo sapiens)
Pi [cytosol]
Pyrimidine catabolism (Homo sapiens)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Homo sapiens)
Pi [cytosol]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Homo sapiens)
Pi [cytosol]
(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Homo sapiens)
Pi [cytosol]
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Homo sapiens)
Pi [cytosol]
thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Homo sapiens)
Pi [cytosol]
Nucleotide salvage (Homo sapiens)
Purine salvage (Homo sapiens)
PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Homo sapiens)
Pi [cytosol]
PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Homo sapiens)
Pi [cytosol]
Pyrimidine salvage (Homo sapiens)
HDHD1:Mg2+ dephosphorylates PURIDP (Homo sapiens)
Pi [cytosol]
thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Homo sapiens)
Pi [cytosol]
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Homo sapiens)
Pi [cytosol]
Metabolism of porphyrins (Homo sapiens)
Heme biosynthesis (Homo sapiens)
ABCG2 tetramer transports heme from cytosol to extracellular region (Homo sapiens)
Pi [cytosol]
Heme degradation (Homo sapiens)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Homo sapiens)
Pi [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Homo sapiens)
Pi [cytosol]
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)
Transport of RCbl within the body (Homo sapiens)
ABCC1 transports cytosolic RCbl to extracellular region (Homo sapiens)
Pi [cytosol]
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Homo sapiens)
Pi [cytosol]
Uptake of dietary cobalamins into enterocytes (Homo sapiens)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Homo sapiens)
Pi [cytosol]
Metabolism of folate and pterines (Homo sapiens)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Homo sapiens)
Pi [cytosol]
FPGS-2 transforms THF to THFPG (Homo sapiens)
Pi [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Homo sapiens)
Pi [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Homo sapiens)
Pi [cytosol]
Nicotinate metabolism (Homo sapiens)
Nicotinamide salvage (Homo sapiens)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Homo sapiens)
Pi [cytosol]
Vitamin B1 (thiamin) metabolism (Homo sapiens)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Homo sapiens)
Pi [cytosol]
Vitamin B2 (riboflavin) metabolism (Homo sapiens)
2xTRAP hydrolyzes FMN to RIB (Homo sapiens)
Pi [cytosol]
Vitamin B5 (pantothenate) metabolism (Homo sapiens)
PANK4 hydrolyzes PPANT to pantetheine (Homo sapiens)
Pi [cytosol]
Pyrophosphate hydrolysis (Homo sapiens)
LHPP:Mg2+ dimer hydrolyses PPi (Homo sapiens)
Pi [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Homo sapiens)
Pi [cytosol]
Metabolism of RNA (Homo sapiens)
Deadenylation-dependent mRNA decay (Homo sapiens)
mRNA decay by 3' to 5' exoribonuclease (Homo sapiens)
NT5C3B hydrolyses 7MGP to 7MG (Homo sapiens)
Pi [cytosol]
tRNA processing (Homo sapiens)
tRNA processing in the nucleus (Homo sapiens)
tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol (Homo sapiens)
Pi [cytosol]
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
Sialic acid metabolism (Homo sapiens)
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Homo sapiens)
Pi [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Homo sapiens)
Pi [cytosol]
Synthesis of dolichyl-phosphate (Homo sapiens)
DOLPP1 dephosphorylates DOLDP to DOLP (Homo sapiens)
Pi [cytosol]
MVD decarboxylates MVA5PP to IPPP (Homo sapiens)
Pi [cytosol]
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Homo sapiens)
Pi [cytosol]
COPII-mediated vesicle transport (Homo sapiens)
Loss of SAR1B GTPase (Homo sapiens)
Pi [cytosol]
NSF ATPase activity dissociates cis-SNARE (Homo sapiens)
Pi [cytosol]
PP6 dephosphorylates SEC24 (Homo sapiens)
Pi [cytosol]
Vesicle budding (Homo sapiens)
Pi [cytosol]
Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)
Pi [cytosol]
TTL ligates L-Tyr to the carboxy terminus of detyr-alpha tubulin:beta tubulin (Homo sapiens)
Pi [cytosol]
TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Homo sapiens)
Pi [cytosol]
TTLLs polyglutamylate tubulin (Homo sapiens)
Pi [cytosol]
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Homo sapiens)
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Homo sapiens)
Pi [cytosol]
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding (Homo sapiens)
Folding of actin by CCT/TriC (Homo sapiens)
Hydrolysis of ATP and release of folded actin from CCT/TriC (Homo sapiens)
Pi [cytosol]
Formation of tubulin folding intermediates by CCT/TriC (Homo sapiens)
Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC (Homo sapiens)
Pi [cytosol]
Post-chaperonin tubulin folding pathway (Homo sapiens)
Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi (Homo sapiens)
Pi [cytosol]
Surfactant metabolism (Homo sapiens)
ABCA3 transports PC, PG from ER membrane to lamellar body (Homo sapiens)
Pi [cytosol]
SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Homo sapiens)
Pi [cytosol]
Translation (Homo sapiens)
Eukaryotic Translation Elongation (Homo sapiens)
Peptide chain elongation (Homo sapiens)
Hydrolysis of eEF1A:GTP (Homo sapiens)
Pi [cytosol]
Translocation of ribosome by 3 bases in the 3' direction (Homo sapiens)
Pi [cytosol]
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Cap-bound mRNA is activated by helicases (Homo sapiens)
Pi [cytosol]
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
Pi [cytosol]
eIF5B:GTP is hydrolyzed and released (Homo sapiens)
Pi [cytosol]
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
Pi [cytosol]
Eukaryotic Translation Termination (Homo sapiens)
GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex (Homo sapiens)
Pi [cytosol]
tRNA Aminoacylation (Homo sapiens)
Cytosolic tRNA aminoacylation (Homo sapiens)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Homo sapiens)
Pi [cytosol]
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Homo sapiens)
Pi [cytosol]
Smooth Muscle Contraction (Homo sapiens)
ATP Hydrolysis By Myosin (Homo sapiens)
Pi [cytosol]
Striated Muscle Contraction (Homo sapiens)
ATP Hydrolysis By Myosin (Homo sapiens)
Pi [cytosol]
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Assembly and cell surface presentation of NMDA receptors (Homo sapiens)
KIF17 transports GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors to the plasma membrane (Homo sapiens)
Pi [cytosol]
Negative regulation of NMDA receptor-mediated neuronal transmission (Homo sapiens)
PPM1F dephosphorylates CAMK1 (Homo sapiens)
Pi [cytosol]
PPM1F dephosphorylates p-T286-CaMKII (Homo sapiens)
Pi [cytosol]
GABA receptor activation (Homo sapiens)
GABA B receptor activation (Homo sapiens)
Activation of GABAB receptors (Homo sapiens)
Adenylate cyclase inhibitory pathway (Homo sapiens)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)
Pi [cytosol]
Adenylate cyclase increases the GTPase activity of Gi alpha (Homo sapiens)
Pi [cytosol]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Homo sapiens)
Trafficking of AMPA receptors (Homo sapiens)
Trafficking of GluR1-containing AMPA receptors (Homo sapiens)
Pi [cytosol]
Trafficking of GluR2-containing AMPA receptors (Homo sapiens)
Endocytosis of Ca impermeable AMPA receptors (Homo sapiens)
Pi [cytosol]
Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Homo sapiens)
Pi [cytosol]
Trafficking of GluR2-containing AMPA receptors to synapse (Homo sapiens)
Pi [cytosol]
Neurotransmitter release cycle (Homo sapiens)
Dopamine Neurotransmitter Release Cycle (Homo sapiens)
Re-acidification of clathrin sculpted monoamine transport vesicle lumen (Homo sapiens)
Pi [cytosol]
Norepinephrine Neurotransmitter Release Cycle (Homo sapiens)
Re-acidification of clathrin sculpted monoamine transport vesicle lumen (Homo sapiens)
Pi [cytosol]
Serotonin Neurotransmitter Release Cycle (Homo sapiens)
Re-acidification of clathrin sculpted monoamine transport vesicle lumen (Homo sapiens)
Pi [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Homo sapiens)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Homo sapiens)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Homo sapiens)
Pi [cytosol]
Organelle biogenesis and maintenance (Homo sapiens)
Cilium Assembly (Homo sapiens)
Cargo trafficking to the periciliary membrane (Homo sapiens)
VxPx cargo-targeting to cilium (Homo sapiens)
ASAP1 stimulates GTPase activity of ARF4 (Homo sapiens)
Pi [cytosol]
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation of BH3-only proteins (Homo sapiens)
Activation of BAD and translocation to mitochondria (Homo sapiens)
Activation of BAD by calcineurin (Homo sapiens)
Pi [cytosol]
Protein localization (Homo sapiens)
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (Homo sapiens)
Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP (Homo sapiens)
Pi [cytosol]
Sensory Perception (Homo sapiens)
Sensory processing of sound (Homo sapiens)
Sensory processing of sound by inner hair cells of the cochlea (Homo sapiens)
ATP2B1 (PMCA1) transports Ca2+ from the cytosol to the extracellular region (Homo sapiens)
Pi [cytosol]
ATP2B2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region (Homo sapiens)
Pi [cytosol]
Sensory processing of sound by outer hair cells of the cochlea (Homo sapiens)
ATP2B2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region (Homo sapiens)
Pi [cytosol]
Visual phototransduction (Homo sapiens)
The canonical retinoid cycle in rods (twilight vision) (Homo sapiens)
ABCA4 mediates atRAL transport (Homo sapiens)
Pi [cytosol]
ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol (Homo sapiens)
Pi [cytosol]
The phototransduction cascade (Homo sapiens)
Inactivation, recovery and regulation of the phototransduction cascade (Homo sapiens)
GNAT1-GTP hydrolyses its bound GTP to GDP (Homo sapiens)
Pi [cytosol]
PP2A dephosphorylates p-RHO to RHO (Homo sapiens)
Pi [cytosol]
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
Pi [cytosol]
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PHLPP dephosphorylates S473 in AKT (Homo sapiens)
Pi [cytosol]
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Homo sapiens)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Homo sapiens)
Pi [cytosol]
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF-independent MAPK1/3 activation (Homo sapiens)
Cytosolic DUSPs dephosphorylate MAPKs (Homo sapiens)
Pi [cytosol]
RAF/MAP kinase cascade (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
Cytosolic DUSPs dephosphorylate MAPKs (Homo sapiens)
Pi [cytosol]
PP2A dephosphorylates RAF1 (Homo sapiens)
Pi [cytosol]
PP5 dephosphorylates RAF1 S338 (Homo sapiens)
Pi [cytosol]
PTPN3 dephosphorylates MAPK12 (Homo sapiens)
Pi [cytosol]
PTPN7 dephosphorylates p-T,Y-MAPKs (Homo sapiens)
Pi [cytosol]
RAF activation (Homo sapiens)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Homo sapiens)
Pi [cytosol]
PP2A dephosphorylates KSR1 (Homo sapiens)
Pi [cytosol]
PP2A dephosphorylates inactive RAFs (Homo sapiens)
Pi [cytosol]
MTOR signalling (Homo sapiens)
Energy dependent regulation of mTOR by LKB1-AMPK (Homo sapiens)
AMPK is dephosphorylated (Homo sapiens)
Pi [cytosol]
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Homo sapiens)
Pi [cytosol]
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
G alpha (i) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
Pi [cytosol]
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Homo sapiens)
Pi [cytosol]
Opioid Signalling (Homo sapiens)
DARPP-32 events (Homo sapiens)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Homo sapiens)
Pi [cytosol]
PPP3 complex dephosphorylates DARPP-32 on Thr34 (Homo sapiens)
Pi [cytosol]
G-protein mediated events (Homo sapiens)
Adenylate cyclase activating pathway (Homo sapiens)
Adenylaye cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)
Pi [cytosol]
Adenylate cyclase inhibitory pathway (Homo sapiens)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)
Pi [cytosol]
Adenylate cyclase increases the GTPase activity of Gi alpha (Homo sapiens)
Pi [cytosol]
PLC beta mediated events (Homo sapiens)
Inactivation of PLC beta (Homo sapiens)
Pi [cytosol]
G alpha (q) signalling events (Homo sapiens)
G alpha (q) in G (q):RGS complex is inactivated (Homo sapiens)
Pi [cytosol]
G alpha (s) signalling events (Homo sapiens)
G alpha (s) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
Pi [cytosol]
G alpha (z) signalling events (Homo sapiens)
G alpha (z) in G alpha (z):RGS complex is inactivated (Homo sapiens)
Pi [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Down-Regulation (Homo sapiens)
PTPN1 dephosphorylates PTK6 (Homo sapiens)
Pi [cytosol]
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Homo sapiens)
ARHGAP35 stimulates RHOA GTPase activity (Homo sapiens)
Pi [cytosol]
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
MDK and PTN in ALK signaling (Homo sapiens)
PTPRZ dephosphorylates ligand-bound ALK dimers (Homo sapiens)
Pi [cytosol]
PTPN6 dephosphorylates JAK3 (Homo sapiens)
Pi [cytosol]
Signaling by EGFR (Homo sapiens)
EGFR downregulation (Homo sapiens)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Homo sapiens)
Pi [cytosol]
PTPN3 dephosphorylates EPS15 (Homo sapiens)
Pi [cytosol]
GAB1 signalosome (Homo sapiens)
Dephosphorylation of Gab1 by SHP2 (Homo sapiens)
Pi [cytosol]
Dephosphorylation of PAG by SHP2 (Homo sapiens)
Pi [cytosol]
SHP2 dephosphorylates Tyr 992 on EGFR (Homo sapiens)
Pi [cytosol]
Sustained activation of SRC kinase by SHP2 (Homo sapiens)
Pi [cytosol]
Signaling by ERBB2 (Homo sapiens)
Downregulation of ERBB2 signaling (Homo sapiens)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Homo sapiens)
Pi [cytosol]
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Homo sapiens)
Pi [cytosol]
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
Negative regulation of FGFR1 signaling (Homo sapiens)
Spry regulation of FGF signaling (Homo sapiens)
PPA2A dephosphorylates SPRY2 (Homo sapiens)
Pi [cytosol]
Signaling by FGFR2 (Homo sapiens)
Negative regulation of FGFR2 signaling (Homo sapiens)
Spry regulation of FGF signaling (Homo sapiens)
PPA2A dephosphorylates SPRY2 (Homo sapiens)
Pi [cytosol]
Signaling by FGFR3 (Homo sapiens)
Negative regulation of FGFR3 signaling (Homo sapiens)
Spry regulation of FGF signaling (Homo sapiens)
PPA2A dephosphorylates SPRY2 (Homo sapiens)
Pi [cytosol]
Signaling by FGFR4 (Homo sapiens)
Negative regulation of FGFR4 signaling (Homo sapiens)
Spry regulation of FGF signaling (Homo sapiens)
PPA2A dephosphorylates SPRY2 (Homo sapiens)
Pi [cytosol]
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor recycling (Homo sapiens)
Insulin receptor de-phosphorylation (Homo sapiens)
Pi [cytosol]
Insulin receptor signalling cascade (Homo sapiens)
Signal attenuation (Homo sapiens)
De-phosphorylation of p-Y427-SHC1 (Homo sapiens)
Pi [cytosol]
Dephosphorylation of p-Y-IRS1,p-Y-IRS2 (Homo sapiens)
Pi [cytosol]
Signaling by MET (Homo sapiens)
Negative regulation of MET activity (Homo sapiens)
PTPN1 and PTPN2 dephosphorylate MET (Homo sapiens)
Pi [cytosol]
PTPRJ dephosphorylates MET (Homo sapiens)
Pi [cytosol]
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Retrograde neurotrophin signalling (Homo sapiens)
Endocytosis (internalization) of clathrin-coated vesicle (Homo sapiens)
Pi [cytosol]
Signaling by NTRK3 (TRKC) (Homo sapiens)
Protein tyrosine phosphatases dephosphorylate NTRK3 (Homo sapiens)
Pi [cytosol]
Signaling by PDGF (Homo sapiens)
PTPN12 dephosphorylates PDGFRB at Y1021 (Homo sapiens)
Pi [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Miro GTPase Cycle (Homo sapiens)
RHOT1 GTPase cycle (Homo sapiens)
RHOT1 hydrolyzes GTP (Homo sapiens)
Pi [cytosol]
RHOT2 GTPase cycle (Homo sapiens)
RHOT2 hydrolyzes GTP (Homo sapiens)
Pi [cytosol]
RHOBTB3 ATPase cycle (Homo sapiens)
RHOBTB3 hydrolyzes ATP (Homo sapiens)
Pi [cytosol]
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Homo sapiens)
Pi [cytosol]
RHO GTPases Activate ROCKs (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
Pi [cytosol]
RHO GTPases activate PAKs (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
Pi [cytosol]
RHO GTPases activate PKNs (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
Pi [cytosol]
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GAPs stimulate CDC42 GTPase activity (Homo sapiens)
Pi [cytosol]
RAC1 GTPase cycle (Homo sapiens)
RAC1 GAPs stimulate RAC1 GTPase activity (Homo sapiens)
Pi [cytosol]
RAC2 GTPase cycle (Homo sapiens)
RAC2 GAPs stimulate RAC2 GTPase activity (Homo sapiens)
Pi [cytosol]
RAC3 GTPase cycle (Homo sapiens)
RAC3 GAPs stimulate RAC3 GTPase activity (Homo sapiens)
Pi [cytosol]
RHOA GTPase cycle (Homo sapiens)
RHOA GAPs stimulate RHOA GTPase activity (Homo sapiens)
Pi [cytosol]
RHOB GTPase cycle (Homo sapiens)
RHOB GAPs stimulate RHOB GTPase activity (Homo sapiens)
Pi [cytosol]
RHOC GTPase cycle (Homo sapiens)
RHOC GAPs stimulate RHOC GTPase activity (Homo sapiens)
Pi [cytosol]
RHOD GTPase cycle (Homo sapiens)
RHOD GAPs stimulate RHOD GTPase activity (Homo sapiens)
Pi [cytosol]
RHOF GTPase cycle (Homo sapiens)
RHOF GAPs stimulate RHOF GTPase activity (Homo sapiens)
Pi [cytosol]
RHOG GTPase cycle (Homo sapiens)
RHOG GAPs stimulate RHOG GTPase activity (Homo sapiens)
Pi [cytosol]
RHOJ GTPase cycle (Homo sapiens)
RHOJ GAPs stimulate RHOJ GTPase activity (Homo sapiens)
Pi [cytosol]
RHOQ GTPase cycle (Homo sapiens)
RHOQ GAPs stimulate RHOQ GTPase activity (Homo sapiens)
Pi [cytosol]
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
MTMR4 dephosphorylates SMAD2/3 (Homo sapiens)
Pi [cytosol]
PP1 dephosphorylates TGFBR1 (Homo sapiens)
Pi [cytosol]
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Homo sapiens)
Pi [cytosol]
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
ABC transporters in lipid homeostasis (Homo sapiens)
ABCA12 transports lipids from cytosol to extracellular region (Homo sapiens)
Pi [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Homo sapiens)
Pi [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Homo sapiens)
Pi [cytosol]
ABCA7:Apo1A-mediated phospholipid efflux (Homo sapiens)
Pi [cytosol]
ABCAs mediate lipid efflux (Homo sapiens)
Pi [cytosol]
ABCAs mediate lipid influx (Homo sapiens)
Pi [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Homo sapiens)
Pi [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Homo sapiens)
Pi [cytosol]
ABCG4 may mediate cholesterol efflux (Homo sapiens)
Pi [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Homo sapiens)
Pi [cytosol]
ABCA4 mediates atRAL transport (Homo sapiens)
Pi [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Homo sapiens)
Pi [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Homo sapiens)
Pi [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Homo sapiens)
Pi [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Homo sapiens)
Pi [cytosol]
HCO3- transport through ion channel (Homo sapiens)
Pi [cytosol]
Mitochondrial ABC transporters (Homo sapiens)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Homo sapiens)
Pi [cytosol]
The ABCC family mediates organic anion transport (Homo sapiens)
Pi [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Homo sapiens)
Pi [cytosol]
Ion channel transport (Homo sapiens)
Ion transport by P-type ATPases (Homo sapiens)
ATP12A:ATP4B exchanges K+ for H+ (Homo sapiens)
Pi [cytosol]
ATP13A1 transports Mn2+ from cytosol to ER lumen (Homo sapiens)
Pi [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Homo sapiens)
Pi [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Homo sapiens)
Pi [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Homo sapiens)
Pi [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Homo sapiens)
Pi [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Homo sapiens)
Pi [cytosol]
ATP7A transports cytosolic Cu2+ to extracellular region (Homo sapiens)
Pi [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Homo sapiens)
Pi [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Homo sapiens)
Pi [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Homo sapiens)
Pi [cytosol]
Stimuli-sensing channels (Homo sapiens)
SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Homo sapiens)
Pi [cytosol]
Iron uptake and transport (Homo sapiens)
ABCG2 tetramer transports heme from cytosol to extracellular region (Homo sapiens)
Pi [cytosol]
Transferrin endocytosis and recycling (Homo sapiens)
Acidification of Tf:TfR1 containing endosome (Homo sapiens)
Pi [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein assembly (Homo sapiens)
HDL assembly (Homo sapiens)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Homo sapiens)
Pi [cytosol]
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Homo sapiens)
Pi [cytosol]
Plasma lipoprotein remodeling (Homo sapiens)
HDL remodeling (Homo sapiens)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Homo sapiens)
Pi [cytosol]
SLC-mediated transmembrane transport (Homo sapiens)
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Organic anion transporters (Homo sapiens)
SLC25A10 mediates exchange of malate and phosphate (Homo sapiens)
Pi [cytosol]
Type I Na+-coupled phosphate co-transport (Homo sapiens)
Pi [cytosol]
Sodium-coupled phosphate cotransporters (Homo sapiens)
SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Homo sapiens)
Pi [cytosol]
Type II Na+/Pi cotransporters (Homo sapiens)
SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Homo sapiens)
Pi [cytosol]
SLC34A3 cotransports Pi, 2Na+ (Homo sapiens)
Pi [cytosol]
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
Pi [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
Pi [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
Pi [cytosol]
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Homo sapiens)
Pi [cytosol]
COPII-mediated vesicle transport (Homo sapiens)
Loss of SAR1B GTPase (Homo sapiens)
Pi [cytosol]
NSF ATPase activity dissociates cis-SNARE (Homo sapiens)
Pi [cytosol]
PP6 dephosphorylates SEC24 (Homo sapiens)
Pi [cytosol]
Vesicle budding (Homo sapiens)
Pi [cytosol]
Endosomal Sorting Complex Required For Transport (ESCRT) (Homo sapiens)
ESCRT Disassembly (Homo sapiens)
Pi [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Golgi-to-ER retrograde transport (Homo sapiens)
COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
NSF ATPase activity dissociates cis-SNARE at the ER (Homo sapiens)
Pi [cytosol]
Rab regulation of trafficking (Homo sapiens)
TBC/RABGAPs (Homo sapiens)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Homo sapiens)
Pi [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Homo sapiens)
Pi [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Homo sapiens)
Pi [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Homo sapiens)
Pi [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Homo sapiens)
Pi [cytosol]
trans-Golgi Network Vesicle Budding (Homo sapiens)
Golgi Associated Vesicle Biogenesis (Homo sapiens)
trans-Golgi Network Coat Assembly (Homo sapiens)
Pi [cytosol]
trans-Golgi Network Derived Vesicle Uncoating (Homo sapiens)
Pi [cytosol]
trans-Golgi Network Vesicle Scission (Homo sapiens)
Pi [cytosol]
Lysosome Vesicle Biogenesis (Homo sapiens)
trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Homo sapiens)
Pi [cytosol]
trans-Golgi Network Lysosomal Vesicle Scission (Homo sapiens)
Pi [cytosol]
trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Homo sapiens)
Pi [cytosol]
Autophagy (Mus musculus)
Macroautophagy (Mus musculus)
ULK1 is dephosphorylated (Mus musculus)
Pi [cytosol]
Cell Cycle (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
M Phase (Mus musculus)
Mitotic Metaphase and Anaphase (Mus musculus)
Mitotic Anaphase (Mus musculus)
Nuclear Envelope (NE) Reassembly (Mus musculus)
Initiation of Nuclear Envelope (NE) Reformation (Mus musculus)
PP2A dephosphorylates BANF1 (Mus musculus)
Pi [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Mus musculus)
RAN stimulates fusion of nuclear envelope (NE) membranes (Mus musculus)
Pi [cytosol]
Sealing of the nuclear envelope (NE) by ESCRT-III (Mus musculus)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Mus musculus)
Pi [cytosol]
Mitotic Prometaphase (Mus musculus)
Condensation of Prometaphase Chromosomes (Mus musculus)
Dephosphorylation of CK2-modified condensin I (Mus musculus)
Pi [cytosol]
Resolution of Sister Chromatid Cohesion (Mus musculus)
PP2A-B56 dephosphorylates centromeric cohesin (Mus musculus)
Pi [cytosol]
PPP1CC dephosphorylates PLK1 (Mus musculus)
Pi [cytosol]
Mitotic G2-G2/M phases (Mus musculus)
G2/M Transition (Mus musculus)
Cyclin A/B1/B2 associated events during G2/M transition (Mus musculus)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Mus musculus)
Pi [cytosol]
Cellular responses to stimuli (Mus musculus)
Cellular responses to mechanical stimuli (Mus musculus)
Response of endothelial cells to shear stress (Mus musculus)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Mus musculus)
PP2A dephosphorylates serine-127 of YAP1 (Mus musculus)
Pi [cytosol]
PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) (Mus musculus)
Pi [cytosol]
Cellular responses to stress (Mus musculus)
Cellular response to heat stress (Mus musculus)
Regulation of HSF1-mediated heat shock response (Mus musculus)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Mus musculus)
Pi [cytosol]
Cellular response to starvation (Mus musculus)
Amino acids regulate mTORC1 (Mus musculus)
RRAGA,B hydrolyzes GTP (Mus musculus)
Pi [cytosol]
RRAGC,D hydrolyzes GTP (Mus musculus)
Pi [cytosol]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Mus musculus)
ATP hydrolysis by HSP70 (Mus musculus)
Pi [cytosol]
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
EPH-Ephrin signaling (Mus musculus)
EPHB-mediated forward signaling (Mus musculus)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Mus musculus)
Pi [cytosol]
L1CAM interactions (Mus musculus)
Recycling pathway of L1 (Mus musculus)
Formation of clathrin coated vesicle (Mus musculus)
Pi [cytosol]
Semaphorin interactions (Mus musculus)
Sema4D in semaphorin signaling (Mus musculus)
Sema4D mediated inhibition of cell attachment and migration (Mus musculus)
Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Mus musculus)
Pi [cytosol]
Inactivation of Rho-GTP by p190RhoGAP (Mus musculus)
Pi [cytosol]
Signaling by ROBO receptors (Mus musculus)
SLIT2:ROBO1 increases RHOA activity (Mus musculus)
MYO9B inactivates RHOA (Mus musculus)
Pi [cytosol]
Drug ADME (Mus musculus)
Aspirin ADME (Mus musculus)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Mus musculus)
Pi [cytosol]
Azathioprine ADME (Mus musculus)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Mus musculus)
Pi [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Mus musculus)
Pi [cytosol]
Paracetamol ADME (Mus musculus)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Mus musculus)
Pi [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Mus musculus)
Pi [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Mus musculus)
Pi [cytosol]
Prednisone ADME (Mus musculus)
ABCB1 transports PREDN,PREDL out of hepatic cells (Mus musculus)
Pi [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Mus musculus)
Pi [cytosol]
ABCB1 transports xenobiotics out of the cell (Mus musculus)
Pi [cytosol]
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional Regulation by TP53 (Mus musculus)
TP53 Regulates Metabolic Genes (Mus musculus)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Mus musculus)
Pi [cytosol]
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Mus musculus)
Pi [cytosol]
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
Platelet Aggregation (Plug Formation) (Mus musculus)
Integrin signaling (Mus musculus)
Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
Pi [cytosol]
Response to elevated platelet cytosolic Ca2+ (Mus musculus)
Platelet degranulation (Mus musculus)
ABCC4 accumulation of dense granule contents (Mus musculus)
Pi [cytosol]
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Class I MHC mediated antigen processing & presentation (Mus musculus)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Mus musculus)
Transport of Antigen peptide in to ER (Mus musculus)
Pi [cytosol]
MHC class II antigen presentation (Mus musculus)
Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Mus musculus)
Pi [cytosol]
Internalization of MHC II:Ii clathrin coated vesicle (Mus musculus)
Pi [cytosol]
Translocation of TGN-lysosome vesicle to lysosome (Mus musculus)
Pi [cytosol]
Regulation of T cell activation by CD28 family (Mus musculus)
Co-inhibition by CTLA4 (Mus musculus)
Dephosphorylation of AKT by PP2A (Mus musculus)
Pi [cytosol]
TCR signaling (Mus musculus)
Downstream TCR signaling (Mus musculus)
Hydrolysis of PIP3 to PI(3,4)P2 (Mus musculus)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Mus musculus)
Pi [cytosol]
Phosphorylation of CD3 and TCR zeta chains (Mus musculus)
Dephosphorylation of Lck-pY505 by CD45 (Mus musculus)
Pi [cytosol]
Inactivation of LCK by PTPN22 (Mus musculus)
Pi [cytosol]
Translocation of ZAP-70 to Immunological synapse (Mus musculus)
PTPN22 dephosphorylates ZAP70 (Mus musculus)
Pi [cytosol]
Cytokine Signaling in Immune system (Mus musculus)
FLT3 Signaling (Mus musculus)
Negative regulation of FLT3 (Mus musculus)
PTPRJ dephosphorylates active FLT3 (Mus musculus)
Pi [cytosol]
Growth hormone receptor signaling (Mus musculus)
PTP1B dephosphorylates GHR (Mus musculus)
Pi [cytosol]
Interferon Signaling (Mus musculus)
Interferon alpha/beta signaling (Mus musculus)
Regulation of IFNA/IFNB signaling (Mus musculus)
Dephosphorylation of JAK1 by SHP1 (Mus musculus)
Pi [cytosol]
Dephosphorylation of STAT1 by SHP2 (Mus musculus)
Pi [cytosol]
Dephosphorylation of TYK2 by PTP1B (Mus musculus)
Pi [cytosol]
Signaling by CSF3 (G-CSF) (Mus musculus)
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Mus musculus)
Pi [cytosol]
Innate Immune System (Mus musculus)
Antimicrobial peptides (Mus musculus)
Ion influx/efflux at host-pathogen interface (Mus musculus)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Mus musculus)
Pi [cytosol]
C-type lectin receptors (CLRs) (Mus musculus)
CLEC7A (Dectin-1) signaling (Mus musculus)
CLEC7A (Dectin-1) induces NFAT activation (Mus musculus)
Calcineurin binds and dephosphorylates NFAT (Mus musculus)
Pi [cytosol]
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated Ca+2 mobilization (Mus musculus)
Calcineurin binds and dephosphorylates NFAT (Mus musculus)
Pi [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
Regulation of actin dynamics for phagocytic cup formation (Mus musculus)
Extension of pseudopodia by myosin-X in a PI3K dependent manner (Mus musculus)
Pi [cytosol]
Role of myosins in phagosome formation (Mus musculus)
Pi [cytosol]
Role of phospholipids in phagocytosis (Mus musculus)
Conversion of PA into DAG by PAP-1 (Mus musculus)
Pi [cytosol]
Metabolism (Mus musculus)
Aerobic respiration and respiratory electron transport (Mus musculus)
Pyruvate metabolism (Mus musculus)
Regulation of pyruvate metabolism (Mus musculus)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Mus musculus)
Pi [cytosol]
Biological oxidations (Mus musculus)
Phase II - Conjugation of compounds (Mus musculus)
Cytosolic sulfonation of small molecules (Mus musculus)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Mus musculus)
Pi [cytosol]
Glutathione conjugation (Mus musculus)
Glutathione synthesis and recycling (Mus musculus)
GCL ligates L-Glu to L-Cys (Mus musculus)
Pi [cytosol]
GSS:Mg2+ dimer synthesizes GSH (Mus musculus)
Pi [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Mus musculus)
Pi [cytosol]
Methylation (Mus musculus)
MAT1A multimers transfer Ado from ATP to L-Met (Mus musculus)
Pi [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Mus musculus)
Pi [cytosol]
Inositol phosphate metabolism (Mus musculus)
Synthesis of IP2, IP, and Ins in the cytosol (Mus musculus)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Mus musculus)
Pi [cytosol]
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Mus musculus)
Pi [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Mus musculus)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Mus musculus)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Mus musculus)
Pi [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Mus musculus)
Pi [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)
Pi [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)
Pi [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)
Pi [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Mus musculus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Mus musculus)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Mus musculus)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Mus musculus)
Pi [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Mus musculus)
Pi [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Mus musculus)
Pi [cytosol]
Synthesis of pyrophosphates in the cytosol (Mus musculus)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Mus musculus)
Pi [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Mus musculus)
Pi [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Mus musculus)
Pi [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Mus musculus)
Pi [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Mus musculus)
Pi [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Mus musculus)
Pi [cytosol]
Metabolism of amino acids and derivatives (Mus musculus)
Glutamate and glutamine metabolism (Mus musculus)
N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Mus musculus)
Pi [cytosol]
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Mus musculus)
Pi [cytosol]
Histidine catabolism (Mus musculus)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Mus musculus)
Pi [cytosol]
Selenoamino acid metabolism (Mus musculus)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Mus musculus)
SeMet is converted to AdoSeMet by MAT (Mus musculus)
Pi [cytosol]
Selenocysteine synthesis (Mus musculus)
SEPHS2 phosphorylates H2Se to form SELP (Mus musculus)
Pi [cytosol]
Serine metabolism (Mus musculus)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Mus musculus)
Pi [cytosol]
Sulfur amino acid metabolism (Mus musculus)
MAT1A multimers transfer Ado from ATP to L-Met (Mus musculus)
Pi [cytosol]
Methionine salvage pathway (Mus musculus)
Acireductone is created (Mus musculus)
Pi [cytosol]
MTA is cleaved and phosphorylated (Mus musculus)
Pi [cytosol]
Metabolism of carbohydrates and carbohydrate derivatives (Mus musculus)
Glucose metabolism (Mus musculus)
Gluconeogenesis (Mus musculus)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Mus musculus)
Pi [cytosol]
GAPDH tetramers reduce 1,3BPG to GA3P (Mus musculus)
Pi [cytosol]
SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Mus musculus)
Pi [cytosol]
SLC7A4 exchanges G6P for Pi across the ER membrane (Mus musculus)
Pi [cytosol]
Glycolysis (Mus musculus)
GADPH tetramer dehydrogenates GA3P (Mus musculus)
Pi [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Mus musculus)
PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (Mus musculus)
Pi [cytosol]
Glycogen metabolism (Mus musculus)
Glycogen synthesis (Mus musculus)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Mus musculus)
Pi [cytosol]
Pentose phosphate pathway (Mus musculus)
5-Phosphoribose 1-diphosphate biosynthesis (Mus musculus)
PRPS dimers pyrophosphorylate R5P using ATP (Mus musculus)
Pi [cytosol]
PRPS1 dimer pyrophosphorylates R5P using dATP (Mus musculus)
Pi [cytosol]
Metabolism of lipids (Mus musculus)
Fatty acid metabolism (Mus musculus)
Arachidonate metabolism (Mus musculus)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Mus musculus)
LTC4 is exported from the cytosol by ABCC1 (Mus musculus)
Pi [cytosol]
Carnitine shuttle (Mus musculus)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Mus musculus)
Pi [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Mus musculus)
Pi [cytosol]
Fatty acyl-CoA biosynthesis (Mus musculus)
ACLY tetramer transforms CIT to Ac-CoA (Mus musculus)
Pi [cytosol]
Formation of Malonyl-CoA from Acetyl-CoA (liver) (Mus musculus)
Pi [cytosol]
Metabolism of steroids (Mus musculus)
Bile acid and bile salt metabolism (Mus musculus)
Recycling of bile acids and salts (Mus musculus)
ABCB11 transports bile salts from cytosol to extracellular region (Mus musculus)
Pi [cytosol]
ABCC3 transports bile salts from cytosol to extracellular region (Mus musculus)
Pi [cytosol]
Synthesis of bile acids and bile salts (Mus musculus)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Mus musculus)
ABCB11 transports bile salts from cytosol to extracellular region (Mus musculus)
Pi [cytosol]
Cholesterol biosynthesis (Mus musculus)
MVD decarboxylates MVA5PP to IPPP (Mus musculus)
Pi [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Mus musculus)
Pi [cytosol]
Phospholipid metabolism (Mus musculus)
Glycerophospholipid biosynthesis (Mus musculus)
PGP:Mg2+ dimer hydrolyses G3P to glycerol (Mus musculus)
Pi [cytosol]
Synthesis of PC (Mus musculus)
PA is dephosphorylated to DAG by LPIN (Mus musculus)
Pi [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Mus musculus)
Pi [cytosol]
Synthesis of PE (Mus musculus)
PA is dephosphorylated to DAG by LPIN (Mus musculus)
Pi [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Mus musculus)
Pi [cytosol]
PI Metabolism (Mus musculus)
Synthesis of PIPs at the ER membrane (Mus musculus)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Mus musculus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Mus musculus)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Mus musculus)
Pi [cytosol]
Synthesis of PIPs at the Golgi membrane (Mus musculus)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Mus musculus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Mus musculus)
Pi [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Mus musculus)
Pi [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Mus musculus)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Mus musculus)
Pi [cytosol]
Synthesis of PIPs at the early endosome membrane (Mus musculus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Mus musculus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Mus musculus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Mus musculus)
Pi [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Mus musculus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Mus musculus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Mus musculus)
Pi [cytosol]
Synthesis of PIPs at the late endosome membrane (Mus musculus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Mus musculus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Mus musculus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Mus musculus)
Pi [cytosol]
Synthesis of PIPs at the plasma membrane (Mus musculus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Mus musculus)
Pi [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Mus musculus)
Pi [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Mus musculus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Mus musculus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Mus musculus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Mus musculus)
Pi [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Mus musculus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Mus musculus)
Pi [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Mus musculus)
Pi [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Mus musculus)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Mus musculus)
Pi [cytosol]
Sphingolipid metabolism (Mus musculus)
Sphingolipid catabolism (Mus musculus)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Mus musculus)
Pi [cytosol]
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Mus musculus)
Pi [cytosol]
Sphingolipid de novo biosynthesis (Mus musculus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Mus musculus)
Pi [cytosol]
Triglyceride metabolism (Mus musculus)
Triglyceride biosynthesis (Mus musculus)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Mus musculus)
Pi [cytosol]
Metabolism of nucleotides (Mus musculus)
Interconversion of nucleotide di- and triphosphates (Mus musculus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Mus musculus)
Pi [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Mus musculus)
Pi [cytosol]
Nucleotide biosynthesis (Mus musculus)
Purine ribonucleoside monophosphate biosynthesis (Mus musculus)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Mus musculus)
Pi [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Mus musculus)
Pi [cytosol]
FGAM + ATP => AIR + ADP + Pi (Mus musculus)
Pi [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Mus musculus)
Pi [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Mus musculus)
Pi [cytosol]
Pyrimidine biosynthesis (Mus musculus)
CAD hexamer transforms CAP to N-carb-L-Asp (Mus musculus)
Pi [cytosol]
CAD hexamer transforms L-Gln to CAP (Mus musculus)
Pi [cytosol]
Nucleotide catabolism (Mus musculus)
Purine catabolism (Mus musculus)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Mus musculus)
Pi [cytosol]
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Mus musculus)
Pi [cytosol]
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Mus musculus)
Pi [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Mus musculus)
Pi [cytosol]
PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Mus musculus)
Pi [cytosol]
PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Mus musculus)
Pi [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Mus musculus)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Mus musculus)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Mus musculus)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)
Pi [cytosol]
Pyrimidine catabolism (Mus musculus)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Mus musculus)
Pi [cytosol]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Mus musculus)
Pi [cytosol]
(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Mus musculus)
Pi [cytosol]
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Mus musculus)
Pi [cytosol]
thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Mus musculus)
Pi [cytosol]
Nucleotide salvage (Mus musculus)
Purine salvage (Mus musculus)
PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Mus musculus)
Pi [cytosol]
PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Mus musculus)
Pi [cytosol]
Pyrimidine salvage (Mus musculus)
HDHD1:Mg2+ dephosphorylates PURIDP (Mus musculus)
Pi [cytosol]
thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Mus musculus)
Pi [cytosol]
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Mus musculus)
Pi [cytosol]
Metabolism of porphyrins (Mus musculus)
Heme biosynthesis (Mus musculus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Mus musculus)
Pi [cytosol]
Heme degradation (Mus musculus)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Mus musculus)
Pi [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Mus musculus)
Pi [cytosol]
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of water-soluble vitamins and cofactors (Mus musculus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Mus musculus)
Transport of RCbl within the body (Mus musculus)
ABCC1 transports cytosolic RCbl to extracellular region (Mus musculus)
Pi [cytosol]
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Mus musculus)
Pi [cytosol]
Uptake of dietary cobalamins into enterocytes (Mus musculus)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Mus musculus)
Pi [cytosol]
Metabolism of folate and pterines (Mus musculus)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Mus musculus)
Pi [cytosol]
FPGS-2 transforms THF to THFPG (Mus musculus)
Pi [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Mus musculus)
Pi [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Mus musculus)
Pi [cytosol]
Nicotinate metabolism (Mus musculus)
Nicotinamide salvage (Mus musculus)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Mus musculus)
Pi [cytosol]
Vitamin B1 (thiamin) metabolism (Mus musculus)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Mus musculus)
Pi [cytosol]
Vitamin B2 (riboflavin) metabolism (Mus musculus)
2xTRAP hydrolyzes FMN to RIB (Mus musculus)
Pi [cytosol]
Vitamin B5 (pantothenate) metabolism (Mus musculus)
PANK4 hydrolyzes PPANT to pantetheine (Mus musculus)
Pi [cytosol]
Pyrophosphate hydrolysis (Mus musculus)
LHPP:Mg2+ dimer hydrolyses PPi (Mus musculus)
Pi [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Mus musculus)
Pi [cytosol]
Metabolism of RNA (Mus musculus)
Deadenylation-dependent mRNA decay (Mus musculus)
mRNA decay by 3' to 5' exoribonuclease (Mus musculus)
NT5C3B hydrolyses 7MGP to 7MG (Mus musculus)
Pi [cytosol]
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Asparagine N-linked glycosylation (Mus musculus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Mus musculus)
Synthesis of substrates in N-glycan biosythesis (Mus musculus)
Sialic acid metabolism (Mus musculus)
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Mus musculus)
Pi [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Mus musculus)
Pi [cytosol]
Synthesis of dolichyl-phosphate (Mus musculus)
DOLPP1 dephosphorylates DOLDP to DOLP (Mus musculus)
Pi [cytosol]
MVD decarboxylates MVA5PP to IPPP (Mus musculus)
Pi [cytosol]
Transport to the Golgi and subsequent modification (Mus musculus)
ER to Golgi Anterograde Transport (Mus musculus)
COPI-mediated anterograde transport (Mus musculus)
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Mus musculus)
Pi [cytosol]
COPII-mediated vesicle transport (Mus musculus)
Loss of SAR1B GTPase (Mus musculus)
Pi [cytosol]
NSF ATPase activity dissociates cis-SNARE (Mus musculus)
Pi [cytosol]
PP6 dephosphorylates SEC24 (Mus musculus)
Pi [cytosol]
Vesicle budding (Mus musculus)
Pi [cytosol]
Carboxyterminal post-translational modifications of tubulin (Mus musculus)
TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Mus musculus)
Pi [cytosol]
TTLLs polyglutamylate tubulin (Mus musculus)
Pi [cytosol]
Protein folding (Mus musculus)
Chaperonin-mediated protein folding (Mus musculus)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Mus musculus)
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Mus musculus)
Pi [cytosol]
Surfactant metabolism (Mus musculus)
ABCA3 transports PC, PG from ER membrane to lamellar body (Mus musculus)
Pi [cytosol]
SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Mus musculus)
Pi [cytosol]
Translation (Mus musculus)
Eukaryotic Translation Initiation (Mus musculus)
Cap-dependent Translation Initiation (Mus musculus)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Mus musculus)
Cap-bound mRNA is activated by helicases (Mus musculus)
Pi [cytosol]
GTP hydrolysis and joining of the 60S ribosomal subunit (Mus musculus)
eIF2:GTP is hydrolyzed, eIFs are released (Mus musculus)
Pi [cytosol]
eIF5B:GTP is hydrolyzed and released (Mus musculus)
Pi [cytosol]
Ribosomal scanning and start codon recognition (Mus musculus)
Ribosomal scanning (Mus musculus)
Pi [cytosol]
tRNA Aminoacylation (Mus musculus)
Cytosolic tRNA aminoacylation (Mus musculus)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Mus musculus)
Pi [cytosol]
Muscle contraction (Mus musculus)
Cardiac conduction (Mus musculus)
Ion homeostasis (Mus musculus)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Mus musculus)
Pi [cytosol]
Smooth Muscle Contraction (Mus musculus)
ATP Hydrolysis By Myosin (Mus musculus)
Pi [cytosol]
Striated Muscle Contraction (Mus musculus)
ATP Hydrolysis By Myosin (Mus musculus)
Pi [cytosol]
Neuronal System (Mus musculus)
Transmission across Chemical Synapses (Mus musculus)
Neurotransmitter receptors and postsynaptic signal transmission (Mus musculus)
GABA receptor activation (Mus musculus)
GABA B receptor activation (Mus musculus)
Activation of GABAB receptors (Mus musculus)
Adenylate cyclase inhibitory pathway (Mus musculus)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Mus musculus)
Pi [cytosol]
Adenylate cyclase increases the GTPase activity of Gi alpha (Mus musculus)
Pi [cytosol]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Mus musculus)
Trafficking of AMPA receptors (Mus musculus)
Trafficking of GluR1-containing AMPA receptors (Mus musculus)
Pi [cytosol]
Trafficking of GluR2-containing AMPA receptors (Mus musculus)
Endocytosis of Ca impermeable AMPA receptors (Mus musculus)
Pi [cytosol]
Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Mus musculus)
Pi [cytosol]
Trafficking of GluR2-containing AMPA receptors to synapse (Mus musculus)
Pi [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Mus musculus)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Mus musculus)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Mus musculus)
Pi [cytosol]
Organelle biogenesis and maintenance (Mus musculus)
Cilium Assembly (Mus musculus)
Cargo trafficking to the periciliary membrane (Mus musculus)
VxPx cargo-targeting to cilium (Mus musculus)
ASAP1 stimulates GTPase activity of ARF4 (Mus musculus)
Pi [cytosol]
Programmed Cell Death (Mus musculus)
Apoptosis (Mus musculus)
Intrinsic Pathway for Apoptosis (Mus musculus)
Activation of BH3-only proteins (Mus musculus)
Activation of BAD and translocation to mitochondria (Mus musculus)
Activation of BAD by calcineurin (Mus musculus)
Pi [cytosol]
Sensory Perception (Mus musculus)
Visual phototransduction (Mus musculus)
The canonical retinoid cycle in rods (twilight vision) (Mus musculus)
ABCA4 mediates atRAL transport (Mus musculus)
Pi [cytosol]
The phototransduction cascade (Mus musculus)
Inactivation, recovery and regulation of the phototransduction cascade (Mus musculus)
GNAT1-GTP hydrolyses its bound GTP to GDP (Mus musculus)
Pi [cytosol]
PP2A dephosphorylates p-RHO to RHO (Mus musculus)
Pi [cytosol]
Signal Transduction (Mus musculus)
Integrin signaling (Mus musculus)
Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
Pi [cytosol]
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
Negative regulation of the PI3K/AKT network (Mus musculus)
PHLPP dephosphorylates S473 in AKT (Mus musculus)
Pi [cytosol]
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Mus musculus)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Mus musculus)
Pi [cytosol]
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF-independent MAPK1/3 activation (Mus musculus)
Cytosolic DUSPs dephosphorylate MAPKs (Mus musculus)
Pi [cytosol]
RAF/MAP kinase cascade (Mus musculus)
Negative regulation of MAPK pathway (Mus musculus)
Cytosolic DUSPs dephosphorylate MAPKs (Mus musculus)
Pi [cytosol]
PP2A dephosphorylates RAF1 (Mus musculus)
Pi [cytosol]
PP5 dephosphorylates RAF1 S338 (Mus musculus)
Pi [cytosol]
PTPN3 dephosphorylates MAPK12 (Mus musculus)
Pi [cytosol]
PTPN7 dephosphorylates p-T,Y-MAPKs (Mus musculus)
Pi [cytosol]
RAF activation (Mus musculus)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Mus musculus)
Pi [cytosol]
PP2A dephosphorylates KSR1 (Mus musculus)
Pi [cytosol]
PP2A dephosphorylates inactive RAFs (Mus musculus)
Pi [cytosol]
MTOR signalling (Mus musculus)
Energy dependent regulation of mTOR by LKB1-AMPK (Mus musculus)
AMPK is dephosphorylated (Mus musculus)
Pi [cytosol]
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Mus musculus)
Pi [cytosol]
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (i) signalling events (Mus musculus)
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Mus musculus)
Pi [cytosol]
Opioid Signalling (Mus musculus)
DARPP-32 events (Mus musculus)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Mus musculus)
Pi [cytosol]
G-protein mediated events (Mus musculus)
Adenylate cyclase activating pathway (Mus musculus)
Adenylaye cyclase increases the GTPase activity of G alpha-olf (Mus musculus)
Pi [cytosol]
Adenylate cyclase inhibitory pathway (Mus musculus)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Mus musculus)
Pi [cytosol]
Adenylate cyclase increases the GTPase activity of Gi alpha (Mus musculus)
Pi [cytosol]
PLC beta mediated events (Mus musculus)
Inactivation of PLC beta (Mus musculus)
Pi [cytosol]
G alpha (q) signalling events (Mus musculus)
G alpha (q) in G (q):RGS complex is inactivated (Mus musculus)
Pi [cytosol]
G alpha (z) signalling events (Mus musculus)
G alpha (z) in G alpha (z):RGS complex is inactivated (Mus musculus)
Pi [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Mus musculus)
Signaling by PTK6 (Mus musculus)
PTK6 Down-Regulation (Mus musculus)
PTPN1 dephosphorylates PTK6 (Mus musculus)
Pi [cytosol]
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Mus musculus)
ARHGAP35 stimulates RHOA GTPase activity (Mus musculus)
Pi [cytosol]
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ALK (Mus musculus)
MDK and PTN in ALK signaling (Mus musculus)
PTPRZ dephosphorylates ligand-bound ALK dimers (Mus musculus)
Pi [cytosol]
PTPN6 dephosphorylates JAK3 (Mus musculus)
Pi [cytosol]
Signaling by EGFR (Mus musculus)
EGFR downregulation (Mus musculus)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Mus musculus)
Pi [cytosol]
PTPN3 dephosphorylates EPS15 (Mus musculus)
Pi [cytosol]
GAB1 signalosome (Mus musculus)
Dephosphorylation of Gab1 by SHP2 (Mus musculus)
Pi [cytosol]
Dephosphorylation of PAG by SHP2 (Mus musculus)
Pi [cytosol]
SHP2 dephosphorylates Tyr 992 on EGFR (Mus musculus)
Pi [cytosol]
Sustained activation of SRC kinase by SHP2 (Mus musculus)
Pi [cytosol]
Signaling by ERBB2 (Mus musculus)
Downregulation of ERBB2 signaling (Mus musculus)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Mus musculus)
Pi [cytosol]
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Mus musculus)
Pi [cytosol]
Signaling by FGFR (Mus musculus)
Signaling by FGFR1 (Mus musculus)
Negative regulation of FGFR1 signaling (Mus musculus)
Spry regulation of FGF signaling (Mus musculus)
PPA2A dephosphorylates SPRY2 (Mus musculus)
Pi [cytosol]
Signaling by FGFR2 (Mus musculus)
Negative regulation of FGFR2 signaling (Mus musculus)
Spry regulation of FGF signaling (Mus musculus)
PPA2A dephosphorylates SPRY2 (Mus musculus)
Pi [cytosol]
Signaling by FGFR3 (Mus musculus)
Negative regulation of FGFR3 signaling (Mus musculus)
Spry regulation of FGF signaling (Mus musculus)
PPA2A dephosphorylates SPRY2 (Mus musculus)
Pi [cytosol]
Signaling by FGFR4 (Mus musculus)
Negative regulation of FGFR4 signaling (Mus musculus)
Spry regulation of FGF signaling (Mus musculus)
PPA2A dephosphorylates SPRY2 (Mus musculus)
Pi [cytosol]
Signaling by Insulin receptor (Mus musculus)
Insulin receptor recycling (Mus musculus)
Insulin receptor de-phosphorylation (Mus musculus)
Pi [cytosol]
Signaling by MET (Mus musculus)
Negative regulation of MET activity (Mus musculus)
PTPN1 and PTPN2 dephosphorylate MET (Mus musculus)
Pi [cytosol]
PTPRJ dephosphorylates MET (Mus musculus)
Pi [cytosol]
Signaling by PDGF (Mus musculus)
PTPN12 dephosphorylates PDGFRB at Y1021 (Mus musculus)
Pi [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Miro GTPase Cycle (Mus musculus)
RHOT1 GTPase cycle (Mus musculus)
RHOT1 hydrolyzes GTP (Mus musculus)
Pi [cytosol]
RHOT2 GTPase cycle (Mus musculus)
RHOT2 hydrolyzes GTP (Mus musculus)
Pi [cytosol]
RHOBTB3 ATPase cycle (Mus musculus)
RHOBTB3 hydrolyzes ATP (Mus musculus)
Pi [cytosol]
Signaling by Rho GTPases (Mus musculus)
RHO GTPase Effectors (Mus musculus)
RHO GTPases Activate Formins (Mus musculus)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Mus musculus)
Pi [cytosol]
RHO GTPase cycle (Mus musculus)
CDC42 GTPase cycle (Mus musculus)
CDC42 GAPs stimulate CDC42 GTPase activity (Mus musculus)
Pi [cytosol]
RAC1 GTPase cycle (Mus musculus)
RAC1 GAPs stimulate RAC1 GTPase activity (Mus musculus)
Pi [cytosol]
RAC2 GTPase cycle (Mus musculus)
RAC2 GAPs stimulate RAC2 GTPase activity (Mus musculus)
Pi [cytosol]
RAC3 GTPase cycle (Mus musculus)
RAC3 GAPs stimulate RAC3 GTPase activity (Mus musculus)
Pi [cytosol]
RHOA GTPase cycle (Mus musculus)
RHOA GAPs stimulate RHOA GTPase activity (Mus musculus)
Pi [cytosol]
RHOB GTPase cycle (Mus musculus)
RHOB GAPs stimulate RHOB GTPase activity (Mus musculus)
Pi [cytosol]
RHOC GTPase cycle (Mus musculus)
RHOC GAPs stimulate RHOC GTPase activity (Mus musculus)
Pi [cytosol]
RHOD GTPase cycle (Mus musculus)
RHOD GAPs stimulate RHOD GTPase activity (Mus musculus)
Pi [cytosol]
RHOF GTPase cycle (Mus musculus)
RHOF GAPs stimulate RHOF GTPase activity (Mus musculus)
Pi [cytosol]
RHOG GTPase cycle (Mus musculus)
RHOG GAPs stimulate RHOG GTPase activity (Mus musculus)
Pi [cytosol]
RHOJ GTPase cycle (Mus musculus)
RHOJ GAPs stimulate RHOJ GTPase activity (Mus musculus)
Pi [cytosol]
RHOQ GTPase cycle (Mus musculus)
RHOQ GAPs stimulate RHOQ GTPase activity (Mus musculus)
Pi [cytosol]
Signaling by TGFB family members (Mus musculus)
Signaling by TGF-beta Receptor Complex (Mus musculus)
TGF-beta receptor signaling activates SMADs (Mus musculus)
Downregulation of TGF-beta receptor signaling (Mus musculus)
MTMR4 dephosphorylates SMAD2/3 (Mus musculus)
Pi [cytosol]
Signaling by WNT (Mus musculus)
Beta-catenin independent WNT signaling (Mus musculus)
Ca2+ pathway (Mus musculus)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Mus musculus)
Pi [cytosol]
Transport of small molecules (Mus musculus)
ABC-family proteins mediated transport (Mus musculus)
ABC transporters in lipid homeostasis (Mus musculus)
ABCA12 transports lipids from cytosol to extracellular region (Mus musculus)
Pi [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Mus musculus)
Pi [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Mus musculus)
Pi [cytosol]
ABCA7:Apo1A-mediated phospholipid efflux (Mus musculus)
Pi [cytosol]
ABCAs mediate lipid efflux (Mus musculus)
Pi [cytosol]
ABCAs mediate lipid influx (Mus musculus)
Pi [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Mus musculus)
Pi [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Mus musculus)
Pi [cytosol]
ABCG4 may mediate cholesterol efflux (Mus musculus)
Pi [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Mus musculus)
Pi [cytosol]
ABCA4 mediates atRAL transport (Mus musculus)
Pi [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Mus musculus)
Pi [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Mus musculus)
Pi [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Mus musculus)
Pi [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Mus musculus)
Pi [cytosol]
HCO3- transport through ion channel (Mus musculus)
Pi [cytosol]
Mitochondrial ABC transporters (Mus musculus)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Mus musculus)
Pi [cytosol]
The ABCC family mediates organic anion transport (Mus musculus)
Pi [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Mus musculus)
Pi [cytosol]
Ion channel transport (Mus musculus)
Ion transport by P-type ATPases (Mus musculus)
ATP12A:ATP4B exchanges K+ for H+ (Mus musculus)
Pi [cytosol]
ATP13A1 transports Mn2+ from cytosol to ER lumen (Mus musculus)
Pi [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Mus musculus)
Pi [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Mus musculus)
Pi [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Mus musculus)
Pi [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Mus musculus)
Pi [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Mus musculus)
Pi [cytosol]
ATP7A transports cytosolic Cu2+ to extracellular region (Mus musculus)
Pi [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Mus musculus)
Pi [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Mus musculus)
Pi [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Mus musculus)
Pi [cytosol]
Stimuli-sensing channels (Mus musculus)
SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Mus musculus)
Pi [cytosol]
Iron uptake and transport (Mus musculus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Mus musculus)
Pi [cytosol]
Transferrin endocytosis and recycling (Mus musculus)
Acidification of Tf:TfR1 containing endosome (Mus musculus)
Pi [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Mus musculus)
Plasma lipoprotein assembly (Mus musculus)
HDL assembly (Mus musculus)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Mus musculus)
Pi [cytosol]
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Mus musculus)
Pi [cytosol]
Plasma lipoprotein remodeling (Mus musculus)
HDL remodeling (Mus musculus)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Mus musculus)
Pi [cytosol]
SLC-mediated transmembrane transport (Mus musculus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Mus musculus)
Organic anion transporters (Mus musculus)
SLC25A10 mediates exchange of malate and phosphate (Mus musculus)
Pi [cytosol]
Type I Na+-coupled phosphate co-transport (Mus musculus)
Pi [cytosol]
Sodium-coupled phosphate cotransporters (Mus musculus)
SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Mus musculus)
Pi [cytosol]
Type II Na+/Pi cotransporters (Mus musculus)
SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Mus musculus)
Pi [cytosol]
SLC34A3 cotransports Pi, 2Na+ (Mus musculus)
Pi [cytosol]
Vesicle-mediated transport (Mus musculus)
Membrane Trafficking (Mus musculus)
Clathrin-mediated endocytosis (Mus musculus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
Pi [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)
Pi [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
Pi [cytosol]
ER to Golgi Anterograde Transport (Mus musculus)
COPI-mediated anterograde transport (Mus musculus)
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Mus musculus)
Pi [cytosol]
COPII-mediated vesicle transport (Mus musculus)
Loss of SAR1B GTPase (Mus musculus)
Pi [cytosol]
NSF ATPase activity dissociates cis-SNARE (Mus musculus)
Pi [cytosol]
PP6 dephosphorylates SEC24 (Mus musculus)
Pi [cytosol]
Vesicle budding (Mus musculus)
Pi [cytosol]
Endosomal Sorting Complex Required For Transport (ESCRT) (Mus musculus)
ESCRT Disassembly (Mus musculus)
Pi [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Mus musculus)
Golgi-to-ER retrograde transport (Mus musculus)
COPI-dependent Golgi-to-ER retrograde traffic (Mus musculus)
NSF ATPase activity dissociates cis-SNARE at the ER (Mus musculus)
Pi [cytosol]
Rab regulation of trafficking (Mus musculus)
TBC/RABGAPs (Mus musculus)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Mus musculus)
Pi [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Mus musculus)
Pi [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Mus musculus)
Pi [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Mus musculus)
Pi [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Mus musculus)
Pi [cytosol]
trans-Golgi Network Vesicle Budding (Mus musculus)
Golgi Associated Vesicle Biogenesis (Mus musculus)
trans-Golgi Network Coat Assembly (Mus musculus)
Pi [cytosol]
trans-Golgi Network Derived Vesicle Uncoating (Mus musculus)
Pi [cytosol]
trans-Golgi Network Vesicle Scission (Mus musculus)
Pi [cytosol]
Lysosome Vesicle Biogenesis (Mus musculus)
trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Mus musculus)
Pi [cytosol]
trans-Golgi Network Lysosomal Vesicle Scission (Mus musculus)
Pi [cytosol]
trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Mus musculus)
Pi [cytosol]
Mycobacterium tuberculosis biological processes (Mycobacterium tuberculosis)
Chorismate via Shikimate Pathway (Mycobacterium tuberculosis)
DHAP from Ery4P and PEP (Mycobacterium tuberculosis)
Pi [cytosol]
DHQ from DAHP dephosphorylation (Mycobacterium tuberculosis)
Pi [cytosol]
Dephosphorylation of EPSP yields chorismate (Mycobacterium tuberculosis)
Pi [cytosol]
EPSP from shikimate 3-phosphate (Mycobacterium tuberculosis)
Pi [cytosol]
Mycothiol metabolism (Mycobacterium tuberculosis)
Mycothiol biosynthesis (Mycobacterium tuberculosis)
acetylglucosamine-inositol-phosphate is dephosphorylated (Mycobacterium tuberculosis)
Pi [cytosol]
Sulfur compound metabolism (Mycobacterium tuberculosis)
Sulfate assimilation (Mycobacterium tuberculosis)
APS is phosphorylated to PAPS (Mycobacterium tuberculosis)
Pi [cytosol]
PAPS is dephosphorylated to APS (Mycobacterium tuberculosis)
Pi [cytosol]
sulfate uptake in the cytosol (Mycobacterium tuberculosis)
Pi [cytosol]
Sulfur amino acid metabolism (Mycobacterium tuberculosis)
Cysteine synthesis from O-phosphoserine (Mycobacterium tuberculosis)
OPS is added to the carrier sulfide (Mycobacterium tuberculosis)
Pi [cytosol]
Trehalose biosynthesis (Mycobacterium tuberculosis)
Trehalose-6-phosphate is hydrolyzed to trehalose (Mycobacterium tuberculosis)
Pi [cytosol]
Cell Cycle (Plasmodium falciparum)
Cell Cycle, Mitotic (Plasmodium falciparum)
M Phase (Plasmodium falciparum)
Mitotic Prometaphase (Plasmodium falciparum)
Condensation of Prometaphase Chromosomes (Plasmodium falciparum)
Dephosphorylation of CK2-modified condensin I (Plasmodium falciparum)
Pi [cytosol]
Resolution of Sister Chromatid Cohesion (Plasmodium falciparum)
PPP1CC dephosphorylates PLK1 (Plasmodium falciparum)
Pi [cytosol]
Cellular responses to stimuli (Plasmodium falciparum)
Cellular responses to stress (Plasmodium falciparum)
Cellular response to heat stress (Plasmodium falciparum)
Regulation of HSF1-mediated heat shock response (Plasmodium falciparum)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Plasmodium falciparum)
Pi [cytosol]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Plasmodium falciparum)
ATP hydrolysis by HSP70 (Plasmodium falciparum)
Pi [cytosol]
Drug ADME (Plasmodium falciparum)
Azathioprine ADME (Plasmodium falciparum)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Plasmodium falciparum)
Pi [cytosol]
Paracetamol ADME (Plasmodium falciparum)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Plasmodium falciparum)
Pi [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Plasmodium falciparum)
Pi [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Plasmodium falciparum)
Pi [cytosol]
Prednisone ADME (Plasmodium falciparum)
ABCB1 transports PREDN,PREDL out of hepatic cells (Plasmodium falciparum)
Pi [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Plasmodium falciparum)
Pi [cytosol]
ABCB1 transports xenobiotics out of the cell (Plasmodium falciparum)
Pi [cytosol]
Hemostasis (Plasmodium falciparum)
Platelet activation, signaling and aggregation (Plasmodium falciparum)
Response to elevated platelet cytosolic Ca2+ (Plasmodium falciparum)
Platelet degranulation (Plasmodium falciparum)
ABCC4 accumulation of dense granule contents (Plasmodium falciparum)
Pi [cytosol]
Metabolism (Plasmodium falciparum)
Biological oxidations (Plasmodium falciparum)
Phase II - Conjugation of compounds (Plasmodium falciparum)
Glutathione conjugation (Plasmodium falciparum)
Glutathione synthesis and recycling (Plasmodium falciparum)
GSS:Mg2+ dimer synthesizes GSH (Plasmodium falciparum)
Pi [cytosol]
Methylation (Plasmodium falciparum)
MAT1A multimers transfer Ado from ATP to L-Met (Plasmodium falciparum)
Pi [cytosol]
Inositol phosphate metabolism (Plasmodium falciparum)
Synthesis of IP2, IP, and Ins in the cytosol (Plasmodium falciparum)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Plasmodium falciparum)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Plasmodium falciparum)
Pi [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Plasmodium falciparum)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Plasmodium falciparum)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Plasmodium falciparum)
Pi [cytosol]
Metabolism of amino acids and derivatives (Plasmodium falciparum)
Selenoamino acid metabolism (Plasmodium falciparum)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Plasmodium falciparum)
SeMet is converted to AdoSeMet by MAT (Plasmodium falciparum)
Pi [cytosol]
Selenocysteine synthesis (Plasmodium falciparum)
SEPHS2 phosphorylates H2Se to form SELP (Plasmodium falciparum)
Pi [cytosol]
Sulfur amino acid metabolism (Plasmodium falciparum)
MAT1A multimers transfer Ado from ATP to L-Met (Plasmodium falciparum)
Pi [cytosol]
Metabolism of carbohydrates and carbohydrate derivatives (Plasmodium falciparum)
Glucose metabolism (Plasmodium falciparum)
Gluconeogenesis (Plasmodium falciparum)
GAPDH tetramers reduce 1,3BPG to GA3P (Plasmodium falciparum)
Pi [cytosol]
Glycolysis (Plasmodium falciparum)
GADPH tetramer dehydrogenates GA3P (Plasmodium falciparum)
Pi [cytosol]
Pentose phosphate pathway (Plasmodium falciparum)
5-Phosphoribose 1-diphosphate biosynthesis (Plasmodium falciparum)
PRPS dimers pyrophosphorylate R5P using ATP (Plasmodium falciparum)
Pi [cytosol]
PRPS1 dimer pyrophosphorylates R5P using dATP (Plasmodium falciparum)
Pi [cytosol]
Metabolism of lipids (Plasmodium falciparum)
Fatty acid metabolism (Plasmodium falciparum)
Carnitine shuttle (Plasmodium falciparum)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Plasmodium falciparum)
Pi [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Plasmodium falciparum)
Pi [cytosol]
Fatty acyl-CoA biosynthesis (Plasmodium falciparum)
Formation of Malonyl-CoA from Acetyl-CoA (liver) (Plasmodium falciparum)
Pi [cytosol]
Metabolism of steroids (Plasmodium falciparum)
Bile acid and bile salt metabolism (Plasmodium falciparum)
Recycling of bile acids and salts (Plasmodium falciparum)
ABCB11 transports bile salts from cytosol to extracellular region (Plasmodium falciparum)
Pi [cytosol]
Synthesis of bile acids and bile salts (Plasmodium falciparum)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Plasmodium falciparum)
ABCB11 transports bile salts from cytosol to extracellular region (Plasmodium falciparum)
Pi [cytosol]
Phospholipid metabolism (Plasmodium falciparum)
Glycerophospholipid biosynthesis (Plasmodium falciparum)
Synthesis of PC (Plasmodium falciparum)
PA is dephosphorylated to DAG by LPIN (Plasmodium falciparum)
Pi [cytosol]
Synthesis of PE (Plasmodium falciparum)
PA is dephosphorylated to DAG by LPIN (Plasmodium falciparum)
Pi [cytosol]
PI Metabolism (Plasmodium falciparum)
Synthesis of PIPs at the ER membrane (Plasmodium falciparum)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Plasmodium falciparum)
Pi [cytosol]
Synthesis of PIPs at the Golgi membrane (Plasmodium falciparum)
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Plasmodium falciparum)
Pi [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Plasmodium falciparum)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Plasmodium falciparum)
Pi [cytosol]
Synthesis of PIPs at the early endosome membrane (Plasmodium falciparum)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Plasmodium falciparum)
Pi [cytosol]
Synthesis of PIPs at the plasma membrane (Plasmodium falciparum)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Plasmodium falciparum)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Plasmodium falciparum)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Plasmodium falciparum)
Pi [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Plasmodium falciparum)
Pi [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Plasmodium falciparum)
Pi [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Plasmodium falciparum)
Pi [cytosol]
Sphingolipid metabolism (Plasmodium falciparum)
Sphingolipid de novo biosynthesis (Plasmodium falciparum)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Plasmodium falciparum)
Pi [cytosol]
Triglyceride metabolism (Plasmodium falciparum)
Triglyceride biosynthesis (Plasmodium falciparum)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Plasmodium falciparum)
Pi [cytosol]
Metabolism of nucleotides (Plasmodium falciparum)
Interconversion of nucleotide di- and triphosphates (Plasmodium falciparum)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Plasmodium falciparum)
Pi [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Plasmodium falciparum)
Pi [cytosol]
Nucleotide biosynthesis (Plasmodium falciparum)
Purine ribonucleoside monophosphate biosynthesis (Plasmodium falciparum)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Plasmodium falciparum)
Pi [cytosol]
Pyrimidine biosynthesis (Plasmodium falciparum)
CAD hexamer transforms CAP to N-carb-L-Asp (Plasmodium falciparum)
Pi [cytosol]
CAD hexamer transforms L-Gln to CAP (Plasmodium falciparum)
Pi [cytosol]
Nucleotide catabolism (Plasmodium falciparum)
Pyrimidine catabolism (Plasmodium falciparum)
(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Plasmodium falciparum)
Pi [cytosol]
Nucleotide salvage (Plasmodium falciparum)
Pyrimidine salvage (Plasmodium falciparum)
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Plasmodium falciparum)
Pi [cytosol]
Metabolism of porphyrins (Plasmodium falciparum)
Heme biosynthesis (Plasmodium falciparum)
ABCG2 tetramer transports heme from cytosol to extracellular region (Plasmodium falciparum)
Pi [cytosol]
Heme degradation (Plasmodium falciparum)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Plasmodium falciparum)
Pi [cytosol]
Metabolism of vitamins and cofactors (Plasmodium falciparum)
Metabolism of water-soluble vitamins and cofactors (Plasmodium falciparum)
Metabolism of folate and pterines (Plasmodium falciparum)
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Plasmodium falciparum)
Pi [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Plasmodium falciparum)
Pi [cytosol]
Nicotinate metabolism (Plasmodium falciparum)
Nicotinamide salvage (Plasmodium falciparum)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Plasmodium falciparum)
Pi [cytosol]
Vitamin B2 (riboflavin) metabolism (Plasmodium falciparum)
2xTRAP hydrolyzes FMN to RIB (Plasmodium falciparum)
Pi [cytosol]
Vitamin B5 (pantothenate) metabolism (Plasmodium falciparum)
PANK4 hydrolyzes PPANT to pantetheine (Plasmodium falciparum)
Pi [cytosol]
Pyrophosphate hydrolysis (Plasmodium falciparum)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Plasmodium falciparum)
Pi [cytosol]
Metabolism of proteins (Plasmodium falciparum)
Post-translational protein modification (Plasmodium falciparum)
Asparagine N-linked glycosylation (Plasmodium falciparum)
Transport to the Golgi and subsequent modification (Plasmodium falciparum)
ER to Golgi Anterograde Transport (Plasmodium falciparum)
COPII-mediated vesicle transport (Plasmodium falciparum)
Loss of SAR1B GTPase (Plasmodium falciparum)
Pi [cytosol]
Carboxyterminal post-translational modifications of tubulin (Plasmodium falciparum)
TTLLs polyglutamylate tubulin (Plasmodium falciparum)
Pi [cytosol]
Protein folding (Plasmodium falciparum)
Chaperonin-mediated protein folding (Plasmodium falciparum)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Plasmodium falciparum)
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Plasmodium falciparum)
Pi [cytosol]
Surfactant metabolism (Plasmodium falciparum)
ABCA3 transports PC, PG from ER membrane to lamellar body (Plasmodium falciparum)
Pi [cytosol]
Translation (Plasmodium falciparum)
Eukaryotic Translation Initiation (Plasmodium falciparum)
Cap-dependent Translation Initiation (Plasmodium falciparum)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Plasmodium falciparum)
Cap-bound mRNA is activated by helicases (Plasmodium falciparum)
Pi [cytosol]
GTP hydrolysis and joining of the 60S ribosomal subunit (Plasmodium falciparum)
eIF5B:GTP is hydrolyzed and released (Plasmodium falciparum)
Pi [cytosol]
Ribosomal scanning and start codon recognition (Plasmodium falciparum)
Ribosomal scanning (Plasmodium falciparum)
Pi [cytosol]
tRNA Aminoacylation (Plasmodium falciparum)
Cytosolic tRNA aminoacylation (Plasmodium falciparum)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Plasmodium falciparum)
Pi [cytosol]
Sensory Perception (Plasmodium falciparum)
Visual phototransduction (Plasmodium falciparum)
The canonical retinoid cycle in rods (twilight vision) (Plasmodium falciparum)
ABCA4 mediates atRAL transport (Plasmodium falciparum)
Pi [cytosol]
Signal Transduction (Plasmodium falciparum)
MAPK family signaling cascades (Plasmodium falciparum)
MAPK1/MAPK3 signaling (Plasmodium falciparum)
RAF-independent MAPK1/3 activation (Plasmodium falciparum)
Cytosolic DUSPs dephosphorylate MAPKs (Plasmodium falciparum)
Pi [cytosol]
RAF/MAP kinase cascade (Plasmodium falciparum)
Negative regulation of MAPK pathway (Plasmodium falciparum)
Cytosolic DUSPs dephosphorylate MAPKs (Plasmodium falciparum)
Pi [cytosol]
PP5 dephosphorylates RAF1 S338 (Plasmodium falciparum)
Pi [cytosol]
Transport of small molecules (Plasmodium falciparum)
ABC-family proteins mediated transport (Plasmodium falciparum)
ABC transporters in lipid homeostasis (Plasmodium falciparum)
ABCA12 transports lipids from cytosol to extracellular region (Plasmodium falciparum)
Pi [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Plasmodium falciparum)
Pi [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Plasmodium falciparum)
Pi [cytosol]
ABCAs mediate lipid efflux (Plasmodium falciparum)
Pi [cytosol]
ABCAs mediate lipid influx (Plasmodium falciparum)
Pi [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Plasmodium falciparum)
Pi [cytosol]
ABCA4 mediates atRAL transport (Plasmodium falciparum)
Pi [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Plasmodium falciparum)
Pi [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Plasmodium falciparum)
Pi [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Plasmodium falciparum)
Pi [cytosol]
HCO3- transport through ion channel (Plasmodium falciparum)
Pi [cytosol]
Mitochondrial ABC transporters (Plasmodium falciparum)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Plasmodium falciparum)
Pi [cytosol]
The ABCC family mediates organic anion transport (Plasmodium falciparum)
Pi [cytosol]
Ion channel transport (Plasmodium falciparum)
Ion transport by P-type ATPases (Plasmodium falciparum)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Plasmodium falciparum)
Pi [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Plasmodium falciparum)
Pi [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Plasmodium falciparum)
Pi [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Plasmodium falciparum)
Pi [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Plasmodium falciparum)
Pi [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Plasmodium falciparum)
Pi [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Plasmodium falciparum)
Pi [cytosol]
Iron uptake and transport (Plasmodium falciparum)
ABCG2 tetramer transports heme from cytosol to extracellular region (Plasmodium falciparum)
Pi [cytosol]
Transferrin endocytosis and recycling (Plasmodium falciparum)
Acidification of Tf:TfR1 containing endosome (Plasmodium falciparum)
Pi [cytosol]
SLC-mediated transmembrane transport (Plasmodium falciparum)
Transport of inorganic cations/anions and amino acids/oligopeptides (Plasmodium falciparum)
Sodium-coupled phosphate cotransporters (Plasmodium falciparum)
SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Plasmodium falciparum)
Pi [cytosol]
Vesicle-mediated transport (Plasmodium falciparum)
Membrane Trafficking (Plasmodium falciparum)
ER to Golgi Anterograde Transport (Plasmodium falciparum)
COPII-mediated vesicle transport (Plasmodium falciparum)
Loss of SAR1B GTPase (Plasmodium falciparum)
Pi [cytosol]
Rab regulation of trafficking (Plasmodium falciparum)
TBC/RABGAPs (Plasmodium falciparum)
TBC1D15 accelerates GTP hydrolysis by RAB7 (Plasmodium falciparum)
Pi [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Plasmodium falciparum)
Pi [cytosol]
Autophagy (Rattus norvegicus)
Macroautophagy (Rattus norvegicus)
ULK1 is dephosphorylated (Rattus norvegicus)
Pi [cytosol]
Cell Cycle (Rattus norvegicus)
Cell Cycle, Mitotic (Rattus norvegicus)
M Phase (Rattus norvegicus)
Mitotic Metaphase and Anaphase (Rattus norvegicus)
Mitotic Anaphase (Rattus norvegicus)
Nuclear Envelope (NE) Reassembly (Rattus norvegicus)
Initiation of Nuclear Envelope (NE) Reformation (Rattus norvegicus)
PP2A dephosphorylates BANF1 (Rattus norvegicus)
Pi [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Rattus norvegicus)
RAN stimulates fusion of nuclear envelope (NE) membranes (Rattus norvegicus)
Pi [cytosol]
Sealing of the nuclear envelope (NE) by ESCRT-III (Rattus norvegicus)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Rattus norvegicus)
Pi [cytosol]
Mitotic Prometaphase (Rattus norvegicus)
Condensation of Prometaphase Chromosomes (Rattus norvegicus)
Dephosphorylation of CK2-modified condensin I (Rattus norvegicus)
Pi [cytosol]
Resolution of Sister Chromatid Cohesion (Rattus norvegicus)
PP2A-B56 dephosphorylates centromeric cohesin (Rattus norvegicus)
Pi [cytosol]
PPP1CC dephosphorylates PLK1 (Rattus norvegicus)
Pi [cytosol]
Mitotic G2-G2/M phases (Rattus norvegicus)
G2/M Transition (Rattus norvegicus)
Cyclin A/B1/B2 associated events during G2/M transition (Rattus norvegicus)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Rattus norvegicus)
Pi [cytosol]
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to mechanical stimuli (Rattus norvegicus)
Response of endothelial cells to shear stress (Rattus norvegicus)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Rattus norvegicus)
PP2A dephosphorylates serine-127 of YAP1 (Rattus norvegicus)
Pi [cytosol]
PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) (Rattus norvegicus)
Pi [cytosol]
Cellular responses to stress (Rattus norvegicus)
Cellular response to heat stress (Rattus norvegicus)
Regulation of HSF1-mediated heat shock response (Rattus norvegicus)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Rattus norvegicus)
Pi [cytosol]
Cellular response to starvation (Rattus norvegicus)
Amino acids regulate mTORC1 (Rattus norvegicus)
RRAGA,B hydrolyzes GTP (Rattus norvegicus)
Pi [cytosol]
RRAGC,D hydrolyzes GTP (Rattus norvegicus)
Pi [cytosol]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Rattus norvegicus)
ATP hydrolysis by HSP70 (Rattus norvegicus)
Pi [cytosol]
Developmental Biology (Rattus norvegicus)
Nervous system development (Rattus norvegicus)
Axon guidance (Rattus norvegicus)
EPH-Ephrin signaling (Rattus norvegicus)
EPHB-mediated forward signaling (Rattus norvegicus)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Rattus norvegicus)
Pi [cytosol]
L1CAM interactions (Rattus norvegicus)
Recycling pathway of L1 (Rattus norvegicus)
Formation of clathrin coated vesicle (Rattus norvegicus)
Pi [cytosol]
Semaphorin interactions (Rattus norvegicus)
Sema4D in semaphorin signaling (Rattus norvegicus)
Sema4D mediated inhibition of cell attachment and migration (Rattus norvegicus)
Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Rattus norvegicus)
Pi [cytosol]
Inactivation of Rho-GTP by p190RhoGAP (Rattus norvegicus)
Pi [cytosol]
Signaling by ROBO receptors (Rattus norvegicus)
SLIT2:ROBO1 increases RHOA activity (Rattus norvegicus)
MYO9B inactivates RHOA (Rattus norvegicus)
Pi [cytosol]
Drug ADME (Rattus norvegicus)
Aspirin ADME (Rattus norvegicus)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Rattus norvegicus)
Pi [cytosol]
Azathioprine ADME (Rattus norvegicus)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Rattus norvegicus)
Pi [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Rattus norvegicus)
Pi [cytosol]
Paracetamol ADME (Rattus norvegicus)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Rattus norvegicus)
Pi [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Rattus norvegicus)
Pi [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Rattus norvegicus)
Pi [cytosol]
Prednisone ADME (Rattus norvegicus)
ABCB1 transports PREDN,PREDL out of hepatic cells (Rattus norvegicus)
Pi [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Rattus norvegicus)
Pi [cytosol]
ABCB1 transports xenobiotics out of the cell (Rattus norvegicus)
Pi [cytosol]
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional Regulation by TP53 (Rattus norvegicus)
TP53 Regulates Metabolic Genes (Rattus norvegicus)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Rattus norvegicus)
Pi [cytosol]
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Rattus norvegicus)
Pi [cytosol]
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
Platelet Aggregation (Plug Formation) (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Dephosphorylation of inactive SRC by PTPB1 (Rattus norvegicus)
Pi [cytosol]
Response to elevated platelet cytosolic Ca2+ (Rattus norvegicus)
Platelet degranulation (Rattus norvegicus)
ABCC4 accumulation of dense granule contents (Rattus norvegicus)
Pi [cytosol]
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Rattus norvegicus)
Transport of Antigen peptide in to ER (Rattus norvegicus)
Pi [cytosol]
MHC class II antigen presentation (Rattus norvegicus)
Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Rattus norvegicus)
Pi [cytosol]
Internalization of MHC II:Ii clathrin coated vesicle (Rattus norvegicus)
Pi [cytosol]
Translocation of TGN-lysosome vesicle to lysosome (Rattus norvegicus)
Pi [cytosol]
Regulation of T cell activation by CD28 family (Rattus norvegicus)
Co-inhibition by CTLA4 (Rattus norvegicus)
Dephosphorylation of AKT by PP2A (Rattus norvegicus)
Pi [cytosol]
TCR signaling (Rattus norvegicus)
Downstream TCR signaling (Rattus norvegicus)
Hydrolysis of PIP3 to PI(3,4)P2 (Rattus norvegicus)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Rattus norvegicus)
Pi [cytosol]
Phosphorylation of CD3 and TCR zeta chains (Rattus norvegicus)
Dephosphorylation of Lck-pY505 by CD45 (Rattus norvegicus)
Pi [cytosol]
Inactivation of LCK by PTPN22 (Rattus norvegicus)
Pi [cytosol]
Translocation of ZAP-70 to Immunological synapse (Rattus norvegicus)
PTPN22 dephosphorylates ZAP70 (Rattus norvegicus)
Pi [cytosol]
Cytokine Signaling in Immune system (Rattus norvegicus)
Growth hormone receptor signaling (Rattus norvegicus)
PTP1B dephosphorylates GHR (Rattus norvegicus)
Pi [cytosol]
Interferon Signaling (Rattus norvegicus)
Interferon alpha/beta signaling (Rattus norvegicus)
Regulation of IFNA/IFNB signaling (Rattus norvegicus)
Dephosphorylation of JAK1 by SHP1 (Rattus norvegicus)
Pi [cytosol]
Dephosphorylation of STAT1 by SHP2 (Rattus norvegicus)
Pi [cytosol]
Dephosphorylation of TYK2 by PTP1B (Rattus norvegicus)
Pi [cytosol]
Signaling by CSF3 (G-CSF) (Rattus norvegicus)
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Rattus norvegicus)
Pi [cytosol]
Innate Immune System (Rattus norvegicus)
Antimicrobial peptides (Rattus norvegicus)
Ion influx/efflux at host-pathogen interface (Rattus norvegicus)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Rattus norvegicus)
Pi [cytosol]
C-type lectin receptors (CLRs) (Rattus norvegicus)
CLEC7A (Dectin-1) signaling (Rattus norvegicus)
CLEC7A (Dectin-1) induces NFAT activation (Rattus norvegicus)
Calcineurin binds and dephosphorylates NFAT (Rattus norvegicus)
Pi [cytosol]
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
FCERI mediated Ca+2 mobilization (Rattus norvegicus)
Calcineurin binds and dephosphorylates NFAT (Rattus norvegicus)
Pi [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
Regulation of actin dynamics for phagocytic cup formation (Rattus norvegicus)
Extension of pseudopodia by myosin-X in a PI3K dependent manner (Rattus norvegicus)
Pi [cytosol]
Role of myosins in phagosome formation (Rattus norvegicus)
Pi [cytosol]
Role of phospholipids in phagocytosis (Rattus norvegicus)
Conversion of PA into DAG by PAP-1 (Rattus norvegicus)
Pi [cytosol]
Metabolism (Rattus norvegicus)
Aerobic respiration and respiratory electron transport (Rattus norvegicus)
Pyruvate metabolism (Rattus norvegicus)
Regulation of pyruvate metabolism (Rattus norvegicus)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Rattus norvegicus)
Pi [cytosol]
Biological oxidations (Rattus norvegicus)
Phase II - Conjugation of compounds (Rattus norvegicus)
Cytosolic sulfonation of small molecules (Rattus norvegicus)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Rattus norvegicus)
Pi [cytosol]
Glutathione conjugation (Rattus norvegicus)
Glutathione synthesis and recycling (Rattus norvegicus)
GCL ligates L-Glu to L-Cys (Rattus norvegicus)
Pi [cytosol]
GSS:Mg2+ dimer synthesizes GSH (Rattus norvegicus)
Pi [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Rattus norvegicus)
Pi [cytosol]
Methylation (Rattus norvegicus)
MAT1A multimers transfer Ado from ATP to L-Met (Rattus norvegicus)
Pi [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Rattus norvegicus)
Pi [cytosol]
Inositol phosphate metabolism (Rattus norvegicus)
Synthesis of IP2, IP, and Ins in the cytosol (Rattus norvegicus)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Rattus norvegicus)
Pi [cytosol]
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Rattus norvegicus)
Pi [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Rattus norvegicus)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Rattus norvegicus)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Rattus norvegicus)
Pi [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Rattus norvegicus)
Pi [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)
Pi [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)
Pi [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)
Pi [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Rattus norvegicus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Rattus norvegicus)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Rattus norvegicus)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Rattus norvegicus)
Pi [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Rattus norvegicus)
Pi [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Rattus norvegicus)
Pi [cytosol]
Synthesis of pyrophosphates in the cytosol (Rattus norvegicus)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Rattus norvegicus)
Pi [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Rattus norvegicus)
Pi [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Rattus norvegicus)
Pi [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Rattus norvegicus)
Pi [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Rattus norvegicus)
Pi [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Rattus norvegicus)
Pi [cytosol]
Metabolism of amino acids and derivatives (Rattus norvegicus)
Glutamate and glutamine metabolism (Rattus norvegicus)
N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Rattus norvegicus)
Pi [cytosol]
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Rattus norvegicus)
Pi [cytosol]
Histidine catabolism (Rattus norvegicus)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Rattus norvegicus)
Pi [cytosol]
Selenoamino acid metabolism (Rattus norvegicus)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Rattus norvegicus)
SeMet is converted to AdoSeMet by MAT (Rattus norvegicus)
Pi [cytosol]
Selenocysteine synthesis (Rattus norvegicus)
SEPHS2 phosphorylates H2Se to form SELP (Rattus norvegicus)
Pi [cytosol]
Serine metabolism (Rattus norvegicus)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Rattus norvegicus)
Pi [cytosol]
Sulfur amino acid metabolism (Rattus norvegicus)
MAT1A multimers transfer Ado from ATP to L-Met (Rattus norvegicus)
Pi [cytosol]
Methionine salvage pathway (Rattus norvegicus)
Acireductone is created (Rattus norvegicus)
Pi [cytosol]
MTA is cleaved and phosphorylated (Rattus norvegicus)
Pi [cytosol]
Metabolism of carbohydrates and carbohydrate derivatives (Rattus norvegicus)
Glucose metabolism (Rattus norvegicus)
Gluconeogenesis (Rattus norvegicus)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Rattus norvegicus)
Pi [cytosol]
GAPDH tetramers reduce 1,3BPG to GA3P (Rattus norvegicus)
Pi [cytosol]
SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Rattus norvegicus)
Pi [cytosol]
SLC7A4 exchanges G6P for Pi across the ER membrane (Rattus norvegicus)
Pi [cytosol]
Glycolysis (Rattus norvegicus)
GADPH tetramer dehydrogenates GA3P (Rattus norvegicus)
Pi [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Rattus norvegicus)
PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (Rattus norvegicus)
Pi [cytosol]
Glycogen metabolism (Rattus norvegicus)
Glycogen synthesis (Rattus norvegicus)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Rattus norvegicus)
Pi [cytosol]
Pentose phosphate pathway (Rattus norvegicus)
5-Phosphoribose 1-diphosphate biosynthesis (Rattus norvegicus)
PRPS dimers pyrophosphorylate R5P using ATP (Rattus norvegicus)
Pi [cytosol]
PRPS1 dimer pyrophosphorylates R5P using dATP (Rattus norvegicus)
Pi [cytosol]
Metabolism of lipids (Rattus norvegicus)
Fatty acid metabolism (Rattus norvegicus)
Arachidonate metabolism (Rattus norvegicus)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Rattus norvegicus)
LTC4 is exported from the cytosol by ABCC1 (Rattus norvegicus)
Pi [cytosol]
Carnitine shuttle (Rattus norvegicus)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Rattus norvegicus)
Pi [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Rattus norvegicus)
Pi [cytosol]
Fatty acyl-CoA biosynthesis (Rattus norvegicus)
ACLY tetramer transforms CIT to Ac-CoA (Rattus norvegicus)
Pi [cytosol]
Formation of Malonyl-CoA from Acetyl-CoA (liver) (Rattus norvegicus)
Pi [cytosol]
Metabolism of steroids (Rattus norvegicus)
Bile acid and bile salt metabolism (Rattus norvegicus)
Recycling of bile acids and salts (Rattus norvegicus)
ABCB11 transports bile salts from cytosol to extracellular region (Rattus norvegicus)
Pi [cytosol]
ABCC3 transports bile salts from cytosol to extracellular region (Rattus norvegicus)
Pi [cytosol]
Synthesis of bile acids and bile salts (Rattus norvegicus)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Rattus norvegicus)
ABCB11 transports bile salts from cytosol to extracellular region (Rattus norvegicus)
Pi [cytosol]
Cholesterol biosynthesis (Rattus norvegicus)
MVD decarboxylates MVA5PP to IPPP (Rattus norvegicus)
Pi [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Rattus norvegicus)
Pi [cytosol]
Phospholipid metabolism (Rattus norvegicus)
Glycerophospholipid biosynthesis (Rattus norvegicus)
PGP:Mg2+ dimer hydrolyses G3P to glycerol (Rattus norvegicus)
Pi [cytosol]
Synthesis of PC (Rattus norvegicus)
PA is dephosphorylated to DAG by LPIN (Rattus norvegicus)
Pi [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Rattus norvegicus)
Pi [cytosol]
Synthesis of PE (Rattus norvegicus)
PA is dephosphorylated to DAG by LPIN (Rattus norvegicus)
Pi [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Rattus norvegicus)
Pi [cytosol]
PI Metabolism (Rattus norvegicus)
Synthesis of PIPs at the ER membrane (Rattus norvegicus)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Rattus norvegicus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Rattus norvegicus)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Rattus norvegicus)
Pi [cytosol]
Synthesis of PIPs at the Golgi membrane (Rattus norvegicus)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Rattus norvegicus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Rattus norvegicus)
Pi [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Rattus norvegicus)
Pi [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Rattus norvegicus)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Rattus norvegicus)
Pi [cytosol]
Synthesis of PIPs at the early endosome membrane (Rattus norvegicus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Rattus norvegicus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Rattus norvegicus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Rattus norvegicus)
Pi [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Rattus norvegicus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Rattus norvegicus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Rattus norvegicus)
Pi [cytosol]
Synthesis of PIPs at the late endosome membrane (Rattus norvegicus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Rattus norvegicus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Rattus norvegicus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Rattus norvegicus)
Pi [cytosol]
Synthesis of PIPs at the plasma membrane (Rattus norvegicus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Rattus norvegicus)
Pi [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Rattus norvegicus)
Pi [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Rattus norvegicus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Rattus norvegicus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Rattus norvegicus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Rattus norvegicus)
Pi [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Rattus norvegicus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Rattus norvegicus)
Pi [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Rattus norvegicus)
Pi [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Rattus norvegicus)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Rattus norvegicus)
Pi [cytosol]
Sphingolipid metabolism (Rattus norvegicus)
Sphingolipid catabolism (Rattus norvegicus)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Rattus norvegicus)
Pi [cytosol]
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Rattus norvegicus)
Pi [cytosol]
Sphingolipid de novo biosynthesis (Rattus norvegicus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Rattus norvegicus)
Pi [cytosol]
Triglyceride metabolism (Rattus norvegicus)
Triglyceride biosynthesis (Rattus norvegicus)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Rattus norvegicus)
Pi [cytosol]
Metabolism of nucleotides (Rattus norvegicus)
Interconversion of nucleotide di- and triphosphates (Rattus norvegicus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Rattus norvegicus)
Pi [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Rattus norvegicus)
Pi [cytosol]
Nucleotide biosynthesis (Rattus norvegicus)
Purine ribonucleoside monophosphate biosynthesis (Rattus norvegicus)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Rattus norvegicus)
Pi [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Rattus norvegicus)
Pi [cytosol]
FGAM + ATP => AIR + ADP + Pi (Rattus norvegicus)
Pi [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Rattus norvegicus)
Pi [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Rattus norvegicus)
Pi [cytosol]
Pyrimidine biosynthesis (Rattus norvegicus)
CAD hexamer transforms CAP to N-carb-L-Asp (Rattus norvegicus)
Pi [cytosol]
CAD hexamer transforms L-Gln to CAP (Rattus norvegicus)
Pi [cytosol]
Nucleotide catabolism (Rattus norvegicus)
Purine catabolism (Rattus norvegicus)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Rattus norvegicus)
Pi [cytosol]
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Rattus norvegicus)
Pi [cytosol]
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Rattus norvegicus)
Pi [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Rattus norvegicus)
Pi [cytosol]
PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Rattus norvegicus)
Pi [cytosol]
PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Rattus norvegicus)
Pi [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Rattus norvegicus)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Rattus norvegicus)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Rattus norvegicus)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Rattus norvegicus)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Rattus norvegicus)
Pi [cytosol]
Pyrimidine catabolism (Rattus norvegicus)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Rattus norvegicus)
Pi [cytosol]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Rattus norvegicus)
Pi [cytosol]
(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Rattus norvegicus)
Pi [cytosol]
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Rattus norvegicus)
Pi [cytosol]
thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Rattus norvegicus)
Pi [cytosol]
Nucleotide salvage (Rattus norvegicus)
Purine salvage (Rattus norvegicus)
PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Rattus norvegicus)
Pi [cytosol]
PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Rattus norvegicus)
Pi [cytosol]
Pyrimidine salvage (Rattus norvegicus)
HDHD1:Mg2+ dephosphorylates PURIDP (Rattus norvegicus)
Pi [cytosol]
thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Rattus norvegicus)
Pi [cytosol]
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Rattus norvegicus)
Pi [cytosol]
Metabolism of porphyrins (Rattus norvegicus)
Heme biosynthesis (Rattus norvegicus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Rattus norvegicus)
Pi [cytosol]
Heme degradation (Rattus norvegicus)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Rattus norvegicus)
Pi [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Rattus norvegicus)
Pi [cytosol]
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of water-soluble vitamins and cofactors (Rattus norvegicus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Rattus norvegicus)
Transport of RCbl within the body (Rattus norvegicus)
ABCC1 transports cytosolic RCbl to extracellular region (Rattus norvegicus)
Pi [cytosol]
Metabolism of folate and pterines (Rattus norvegicus)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Rattus norvegicus)
Pi [cytosol]
FPGS-2 transforms THF to THFPG (Rattus norvegicus)
Pi [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Rattus norvegicus)
Pi [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Rattus norvegicus)
Pi [cytosol]
Nicotinate metabolism (Rattus norvegicus)
Nicotinamide salvage (Rattus norvegicus)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Rattus norvegicus)
Pi [cytosol]
Vitamin B1 (thiamin) metabolism (Rattus norvegicus)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Rattus norvegicus)
Pi [cytosol]
Vitamin B2 (riboflavin) metabolism (Rattus norvegicus)
2xTRAP hydrolyzes FMN to RIB (Rattus norvegicus)
Pi [cytosol]
Vitamin B5 (pantothenate) metabolism (Rattus norvegicus)
PANK4 hydrolyzes PPANT to pantetheine (Rattus norvegicus)
Pi [cytosol]
Pyrophosphate hydrolysis (Rattus norvegicus)
LHPP:Mg2+ dimer hydrolyses PPi (Rattus norvegicus)
Pi [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Rattus norvegicus)
Pi [cytosol]
Metabolism of RNA (Rattus norvegicus)
Deadenylation-dependent mRNA decay (Rattus norvegicus)
mRNA decay by 3' to 5' exoribonuclease (Rattus norvegicus)
NT5C3B hydrolyses 7MGP to 7MG (Rattus norvegicus)
Pi [cytosol]
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Asparagine N-linked glycosylation (Rattus norvegicus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Rattus norvegicus)
Synthesis of substrates in N-glycan biosythesis (Rattus norvegicus)
Sialic acid metabolism (Rattus norvegicus)
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Rattus norvegicus)
Pi [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Rattus norvegicus)
Pi [cytosol]
Synthesis of dolichyl-phosphate (Rattus norvegicus)
DOLPP1 dephosphorylates DOLDP to DOLP (Rattus norvegicus)
Pi [cytosol]
MVD decarboxylates MVA5PP to IPPP (Rattus norvegicus)
Pi [cytosol]
Transport to the Golgi and subsequent modification (Rattus norvegicus)
ER to Golgi Anterograde Transport (Rattus norvegicus)
COPI-mediated anterograde transport (Rattus norvegicus)
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Rattus norvegicus)
Pi [cytosol]
COPII-mediated vesicle transport (Rattus norvegicus)
Loss of SAR1B GTPase (Rattus norvegicus)
Pi [cytosol]
NSF ATPase activity dissociates cis-SNARE (Rattus norvegicus)
Pi [cytosol]
PP6 dephosphorylates SEC24 (Rattus norvegicus)
Pi [cytosol]
Vesicle budding (Rattus norvegicus)
Pi [cytosol]
Carboxyterminal post-translational modifications of tubulin (Rattus norvegicus)
TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Rattus norvegicus)
Pi [cytosol]
TTLLs polyglutamylate tubulin (Rattus norvegicus)
Pi [cytosol]
Protein folding (Rattus norvegicus)
Chaperonin-mediated protein folding (Rattus norvegicus)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Rattus norvegicus)
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Rattus norvegicus)
Pi [cytosol]
Surfactant metabolism (Rattus norvegicus)
ABCA3 transports PC, PG from ER membrane to lamellar body (Rattus norvegicus)
Pi [cytosol]
SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Rattus norvegicus)
Pi [cytosol]
Translation (Rattus norvegicus)
Eukaryotic Translation Initiation (Rattus norvegicus)
Cap-dependent Translation Initiation (Rattus norvegicus)
GTP hydrolysis and joining of the 60S ribosomal subunit (Rattus norvegicus)
eIF5B:GTP is hydrolyzed and released (Rattus norvegicus)
Pi [cytosol]
Ribosomal scanning and start codon recognition (Rattus norvegicus)
Ribosomal scanning (Rattus norvegicus)
Pi [cytosol]
tRNA Aminoacylation (Rattus norvegicus)
Cytosolic tRNA aminoacylation (Rattus norvegicus)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Rattus norvegicus)
Pi [cytosol]
Muscle contraction (Rattus norvegicus)
Cardiac conduction (Rattus norvegicus)
Ion homeostasis (Rattus norvegicus)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Rattus norvegicus)
Pi [cytosol]
Striated Muscle Contraction (Rattus norvegicus)
ATP Hydrolysis By Myosin (Rattus norvegicus)
Pi [cytosol]
Neuronal System (Rattus norvegicus)
Transmission across Chemical Synapses (Rattus norvegicus)
Neurotransmitter receptors and postsynaptic signal transmission (Rattus norvegicus)
GABA receptor activation (Rattus norvegicus)
GABA B receptor activation (Rattus norvegicus)
Activation of GABAB receptors (Rattus norvegicus)
Adenylate cyclase inhibitory pathway (Rattus norvegicus)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Rattus norvegicus)
Pi [cytosol]
Adenylate cyclase increases the GTPase activity of Gi alpha (Rattus norvegicus)
Pi [cytosol]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Rattus norvegicus)
Trafficking of AMPA receptors (Rattus norvegicus)
Trafficking of GluR1-containing AMPA receptors (Rattus norvegicus)
Pi [cytosol]
Trafficking of GluR2-containing AMPA receptors (Rattus norvegicus)
Endocytosis of Ca impermeable AMPA receptors (Rattus norvegicus)
Pi [cytosol]
Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Rattus norvegicus)
Pi [cytosol]
Trafficking of GluR2-containing AMPA receptors to synapse (Rattus norvegicus)
Pi [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Rattus norvegicus)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Rattus norvegicus)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Rattus norvegicus)
Pi [cytosol]
Organelle biogenesis and maintenance (Rattus norvegicus)
Cilium Assembly (Rattus norvegicus)
Cargo trafficking to the periciliary membrane (Rattus norvegicus)
VxPx cargo-targeting to cilium (Rattus norvegicus)
ASAP1 stimulates GTPase activity of ARF4 (Rattus norvegicus)
Pi [cytosol]
Programmed Cell Death (Rattus norvegicus)
Apoptosis (Rattus norvegicus)
Intrinsic Pathway for Apoptosis (Rattus norvegicus)
Activation of BH3-only proteins (Rattus norvegicus)
Activation of BAD and translocation to mitochondria (Rattus norvegicus)
Activation of BAD by calcineurin (Rattus norvegicus)
Pi [cytosol]
Sensory Perception (Rattus norvegicus)
Visual phototransduction (Rattus norvegicus)
The phototransduction cascade (Rattus norvegicus)
Inactivation, recovery and regulation of the phototransduction cascade (Rattus norvegicus)
GNAT1-GTP hydrolyses its bound GTP to GDP (Rattus norvegicus)
Pi [cytosol]
PP2A dephosphorylates p-RHO to RHO (Rattus norvegicus)
Pi [cytosol]
Signal Transduction (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Dephosphorylation of inactive SRC by PTPB1 (Rattus norvegicus)
Pi [cytosol]
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
Negative regulation of the PI3K/AKT network (Rattus norvegicus)
PHLPP dephosphorylates S473 in AKT (Rattus norvegicus)
Pi [cytosol]
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Rattus norvegicus)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Rattus norvegicus)
Pi [cytosol]
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF-independent MAPK1/3 activation (Rattus norvegicus)
Cytosolic DUSPs dephosphorylate MAPKs (Rattus norvegicus)
Pi [cytosol]
RAF/MAP kinase cascade (Rattus norvegicus)
Negative regulation of MAPK pathway (Rattus norvegicus)
Cytosolic DUSPs dephosphorylate MAPKs (Rattus norvegicus)
Pi [cytosol]
PP2A dephosphorylates RAF1 (Rattus norvegicus)
Pi [cytosol]
PP5 dephosphorylates RAF1 S338 (Rattus norvegicus)
Pi [cytosol]
PTPN3 dephosphorylates MAPK12 (Rattus norvegicus)
Pi [cytosol]
PTPN7 dephosphorylates p-T,Y-MAPKs (Rattus norvegicus)
Pi [cytosol]
RAF activation (Rattus norvegicus)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Rattus norvegicus)
Pi [cytosol]
PP2A dephosphorylates KSR1 (Rattus norvegicus)
Pi [cytosol]
PP2A dephosphorylates inactive RAFs (Rattus norvegicus)
Pi [cytosol]
MTOR signalling (Rattus norvegicus)
Energy dependent regulation of mTOR by LKB1-AMPK (Rattus norvegicus)
AMPK is dephosphorylated (Rattus norvegicus)
Pi [cytosol]
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Rattus norvegicus)
Pi [cytosol]
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (i) signalling events (Rattus norvegicus)
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Rattus norvegicus)
Pi [cytosol]
Opioid Signalling (Rattus norvegicus)
DARPP-32 events (Rattus norvegicus)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Rattus norvegicus)
Pi [cytosol]
G-protein mediated events (Rattus norvegicus)
Adenylate cyclase activating pathway (Rattus norvegicus)
Adenylaye cyclase increases the GTPase activity of G alpha-olf (Rattus norvegicus)
Pi [cytosol]
Adenylate cyclase inhibitory pathway (Rattus norvegicus)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Rattus norvegicus)
Pi [cytosol]
Adenylate cyclase increases the GTPase activity of Gi alpha (Rattus norvegicus)
Pi [cytosol]
PLC beta mediated events (Rattus norvegicus)
Inactivation of PLC beta (Rattus norvegicus)
Pi [cytosol]
G alpha (q) signalling events (Rattus norvegicus)
G alpha (q) in G (q):RGS complex is inactivated (Rattus norvegicus)
Pi [cytosol]
G alpha (z) signalling events (Rattus norvegicus)
G alpha (z) in G alpha (z):RGS complex is inactivated (Rattus norvegicus)
Pi [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by PTK6 (Rattus norvegicus)
PTK6 Down-Regulation (Rattus norvegicus)
PTPN1 dephosphorylates PTK6 (Rattus norvegicus)
Pi [cytosol]
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Rattus norvegicus)
ARHGAP35 stimulates RHOA GTPase activity (Rattus norvegicus)
Pi [cytosol]
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by ALK (Rattus norvegicus)
MDK and PTN in ALK signaling (Rattus norvegicus)
PTPRZ dephosphorylates ligand-bound ALK dimers (Rattus norvegicus)
Pi [cytosol]
PTPN6 dephosphorylates JAK3 (Rattus norvegicus)
Pi [cytosol]
Signaling by EGFR (Rattus norvegicus)
EGFR downregulation (Rattus norvegicus)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Rattus norvegicus)
Pi [cytosol]
PTPN3 dephosphorylates EPS15 (Rattus norvegicus)
Pi [cytosol]
GAB1 signalosome (Rattus norvegicus)
Dephosphorylation of Gab1 by SHP2 (Rattus norvegicus)
Pi [cytosol]
Dephosphorylation of PAG by SHP2 (Rattus norvegicus)
Pi [cytosol]
SHP2 dephosphorylates Tyr 992 on EGFR (Rattus norvegicus)
Pi [cytosol]
Sustained activation of SRC kinase by SHP2 (Rattus norvegicus)
Pi [cytosol]
Signaling by ERBB2 (Rattus norvegicus)
Downregulation of ERBB2 signaling (Rattus norvegicus)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Rattus norvegicus)
Pi [cytosol]
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Rattus norvegicus)
Pi [cytosol]
Signaling by FGFR (Rattus norvegicus)
Signaling by FGFR1 (Rattus norvegicus)
Negative regulation of FGFR1 signaling (Rattus norvegicus)
Spry regulation of FGF signaling (Rattus norvegicus)
PPA2A dephosphorylates SPRY2 (Rattus norvegicus)
Pi [cytosol]
Signaling by FGFR2 (Rattus norvegicus)
Negative regulation of FGFR2 signaling (Rattus norvegicus)
Spry regulation of FGF signaling (Rattus norvegicus)
PPA2A dephosphorylates SPRY2 (Rattus norvegicus)
Pi [cytosol]
Signaling by FGFR3 (Rattus norvegicus)
Negative regulation of FGFR3 signaling (Rattus norvegicus)
Spry regulation of FGF signaling (Rattus norvegicus)
PPA2A dephosphorylates SPRY2 (Rattus norvegicus)
Pi [cytosol]
Signaling by FGFR4 (Rattus norvegicus)
Negative regulation of FGFR4 signaling (Rattus norvegicus)
Spry regulation of FGF signaling (Rattus norvegicus)
PPA2A dephosphorylates SPRY2 (Rattus norvegicus)
Pi [cytosol]
Signaling by Insulin receptor (Rattus norvegicus)
Insulin receptor recycling (Rattus norvegicus)
Insulin receptor de-phosphorylation (Rattus norvegicus)
Pi [cytosol]
Signaling by MET (Rattus norvegicus)
Negative regulation of MET activity (Rattus norvegicus)
PTPN1 and PTPN2 dephosphorylate MET (Rattus norvegicus)
Pi [cytosol]
PTPRJ dephosphorylates MET (Rattus norvegicus)
Pi [cytosol]
Signaling by PDGF (Rattus norvegicus)
PTPN12 dephosphorylates PDGFRB at Y1021 (Rattus norvegicus)
Pi [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
Miro GTPase Cycle (Rattus norvegicus)
RHOT2 GTPase cycle (Rattus norvegicus)
RHOT2 hydrolyzes GTP (Rattus norvegicus)
Pi [cytosol]
RHOBTB3 ATPase cycle (Rattus norvegicus)
RHOBTB3 hydrolyzes ATP (Rattus norvegicus)
Pi [cytosol]
Signaling by Rho GTPases (Rattus norvegicus)
RHO GTPase Effectors (Rattus norvegicus)
RHO GTPases Activate Formins (Rattus norvegicus)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Rattus norvegicus)
Pi [cytosol]
RHO GTPase cycle (Rattus norvegicus)
CDC42 GTPase cycle (Rattus norvegicus)
CDC42 GAPs stimulate CDC42 GTPase activity (Rattus norvegicus)
Pi [cytosol]
RAC1 GTPase cycle (Rattus norvegicus)
RAC1 GAPs stimulate RAC1 GTPase activity (Rattus norvegicus)
Pi [cytosol]
RAC2 GTPase cycle (Rattus norvegicus)
RAC2 GAPs stimulate RAC2 GTPase activity (Rattus norvegicus)
Pi [cytosol]
RHOA GTPase cycle (Rattus norvegicus)
RHOA GAPs stimulate RHOA GTPase activity (Rattus norvegicus)
Pi [cytosol]
RHOB GTPase cycle (Rattus norvegicus)
RHOB GAPs stimulate RHOB GTPase activity (Rattus norvegicus)
Pi [cytosol]
RHOD GTPase cycle (Rattus norvegicus)
RHOD GAPs stimulate RHOD GTPase activity (Rattus norvegicus)
Pi [cytosol]
RHOF GTPase cycle (Rattus norvegicus)
RHOF GAPs stimulate RHOF GTPase activity (Rattus norvegicus)
Pi [cytosol]
RHOG GTPase cycle (Rattus norvegicus)
RHOG GAPs stimulate RHOG GTPase activity (Rattus norvegicus)
Pi [cytosol]
RHOJ GTPase cycle (Rattus norvegicus)
RHOJ GAPs stimulate RHOJ GTPase activity (Rattus norvegicus)
Pi [cytosol]
RHOQ GTPase cycle (Rattus norvegicus)
RHOQ GAPs stimulate RHOQ GTPase activity (Rattus norvegicus)
Pi [cytosol]
Signaling by TGFB family members (Rattus norvegicus)
Signaling by TGF-beta Receptor Complex (Rattus norvegicus)
TGF-beta receptor signaling activates SMADs (Rattus norvegicus)
Downregulation of TGF-beta receptor signaling (Rattus norvegicus)
MTMR4 dephosphorylates SMAD2/3 (Rattus norvegicus)
Pi [cytosol]
Signaling by WNT (Rattus norvegicus)
Beta-catenin independent WNT signaling (Rattus norvegicus)
Ca2+ pathway (Rattus norvegicus)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Rattus norvegicus)
Pi [cytosol]
Transport of small molecules (Rattus norvegicus)
ABC-family proteins mediated transport (Rattus norvegicus)
ABC transporters in lipid homeostasis (Rattus norvegicus)
ABCA12 transports lipids from cytosol to extracellular region (Rattus norvegicus)
Pi [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Rattus norvegicus)
Pi [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Rattus norvegicus)
Pi [cytosol]
ABCA7:Apo1A-mediated phospholipid efflux (Rattus norvegicus)
Pi [cytosol]
ABCAs mediate lipid efflux (Rattus norvegicus)
Pi [cytosol]
ABCAs mediate lipid influx (Rattus norvegicus)
Pi [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Rattus norvegicus)
Pi [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Rattus norvegicus)
Pi [cytosol]
ABCG4 may mediate cholesterol efflux (Rattus norvegicus)
Pi [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Rattus norvegicus)
Pi [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Rattus norvegicus)
Pi [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Rattus norvegicus)
Pi [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Rattus norvegicus)
Pi [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Rattus norvegicus)
Pi [cytosol]
HCO3- transport through ion channel (Rattus norvegicus)
Pi [cytosol]
Mitochondrial ABC transporters (Rattus norvegicus)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Rattus norvegicus)
Pi [cytosol]
The ABCC family mediates organic anion transport (Rattus norvegicus)
Pi [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Rattus norvegicus)
Pi [cytosol]
Ion channel transport (Rattus norvegicus)
Ion transport by P-type ATPases (Rattus norvegicus)
ATP12A:ATP4B exchanges K+ for H+ (Rattus norvegicus)
Pi [cytosol]
ATP13A1 transports Mn2+ from cytosol to ER lumen (Rattus norvegicus)
Pi [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Rattus norvegicus)
Pi [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Rattus norvegicus)
Pi [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Rattus norvegicus)
Pi [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Rattus norvegicus)
Pi [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Rattus norvegicus)
Pi [cytosol]
ATP7A transports cytosolic Cu2+ to extracellular region (Rattus norvegicus)
Pi [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Rattus norvegicus)
Pi [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Rattus norvegicus)
Pi [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Rattus norvegicus)
Pi [cytosol]
Stimuli-sensing channels (Rattus norvegicus)
SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Rattus norvegicus)
Pi [cytosol]
Iron uptake and transport (Rattus norvegicus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Rattus norvegicus)
Pi [cytosol]
Transferrin endocytosis and recycling (Rattus norvegicus)
Acidification of Tf:TfR1 containing endosome (Rattus norvegicus)
Pi [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Rattus norvegicus)
Plasma lipoprotein assembly (Rattus norvegicus)
HDL assembly (Rattus norvegicus)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Rattus norvegicus)
Pi [cytosol]
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Rattus norvegicus)
Pi [cytosol]
Plasma lipoprotein remodeling (Rattus norvegicus)
HDL remodeling (Rattus norvegicus)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Rattus norvegicus)
Pi [cytosol]
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Rattus norvegicus)
Organic anion transporters (Rattus norvegicus)
SLC25A10 mediates exchange of malate and phosphate (Rattus norvegicus)
Pi [cytosol]
Type I Na+-coupled phosphate co-transport (Rattus norvegicus)
Pi [cytosol]
Sodium-coupled phosphate cotransporters (Rattus norvegicus)
SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Rattus norvegicus)
Pi [cytosol]
Type II Na+/Pi cotransporters (Rattus norvegicus)
SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Rattus norvegicus)
Pi [cytosol]
SLC34A3 cotransports Pi, 2Na+ (Rattus norvegicus)
Pi [cytosol]
Vesicle-mediated transport (Rattus norvegicus)
Membrane Trafficking (Rattus norvegicus)
Clathrin-mediated endocytosis (Rattus norvegicus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
Pi [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)
Pi [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
Pi [cytosol]
ER to Golgi Anterograde Transport (Rattus norvegicus)
COPI-mediated anterograde transport (Rattus norvegicus)
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Rattus norvegicus)
Pi [cytosol]
COPII-mediated vesicle transport (Rattus norvegicus)
Loss of SAR1B GTPase (Rattus norvegicus)
Pi [cytosol]
NSF ATPase activity dissociates cis-SNARE (Rattus norvegicus)
Pi [cytosol]
PP6 dephosphorylates SEC24 (Rattus norvegicus)
Pi [cytosol]
Vesicle budding (Rattus norvegicus)
Pi [cytosol]
Endosomal Sorting Complex Required For Transport (ESCRT) (Rattus norvegicus)
ESCRT Disassembly (Rattus norvegicus)
Pi [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Rattus norvegicus)
Golgi-to-ER retrograde transport (Rattus norvegicus)
COPI-dependent Golgi-to-ER retrograde traffic (Rattus norvegicus)
NSF ATPase activity dissociates cis-SNARE at the ER (Rattus norvegicus)
Pi [cytosol]
Rab regulation of trafficking (Rattus norvegicus)
TBC/RABGAPs (Rattus norvegicus)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Rattus norvegicus)
Pi [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Rattus norvegicus)
Pi [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Rattus norvegicus)
Pi [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Rattus norvegicus)
Pi [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Rattus norvegicus)
Pi [cytosol]
trans-Golgi Network Vesicle Budding (Rattus norvegicus)
Golgi Associated Vesicle Biogenesis (Rattus norvegicus)
trans-Golgi Network Coat Assembly (Rattus norvegicus)
Pi [cytosol]
trans-Golgi Network Derived Vesicle Uncoating (Rattus norvegicus)
Pi [cytosol]
trans-Golgi Network Vesicle Scission (Rattus norvegicus)
Pi [cytosol]
Lysosome Vesicle Biogenesis (Rattus norvegicus)
trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Rattus norvegicus)
Pi [cytosol]
trans-Golgi Network Lysosomal Vesicle Scission (Rattus norvegicus)
Pi [cytosol]
trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Rattus norvegicus)
Pi [cytosol]
Autophagy (Saccharomyces cerevisiae)
Macroautophagy (Saccharomyces cerevisiae)
ULK1 is dephosphorylated (Saccharomyces cerevisiae)
Pi [cytosol]
Cell Cycle (Saccharomyces cerevisiae)
Cell Cycle, Mitotic (Saccharomyces cerevisiae)
M Phase (Saccharomyces cerevisiae)
Mitotic Metaphase and Anaphase (Saccharomyces cerevisiae)
Mitotic Anaphase (Saccharomyces cerevisiae)
Nuclear Envelope (NE) Reassembly (Saccharomyces cerevisiae)
Postmitotic nuclear pore complex (NPC) reformation (Saccharomyces cerevisiae)
RAN stimulates fusion of nuclear envelope (NE) membranes (Saccharomyces cerevisiae)
Pi [cytosol]
Mitotic Prometaphase (Saccharomyces cerevisiae)
Condensation of Prometaphase Chromosomes (Saccharomyces cerevisiae)
Dephosphorylation of CK2-modified condensin I (Saccharomyces cerevisiae)
Pi [cytosol]
Resolution of Sister Chromatid Cohesion (Saccharomyces cerevisiae)
PPP1CC dephosphorylates PLK1 (Saccharomyces cerevisiae)
Pi [cytosol]
Cellular responses to stimuli (Saccharomyces cerevisiae)
Cellular responses to stress (Saccharomyces cerevisiae)
Cellular response to heat stress (Saccharomyces cerevisiae)
Regulation of HSF1-mediated heat shock response (Saccharomyces cerevisiae)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Saccharomyces cerevisiae)
Pi [cytosol]
Cellular response to starvation (Saccharomyces cerevisiae)
Amino acids regulate mTORC1 (Saccharomyces cerevisiae)
RRAGA,B hydrolyzes GTP (Saccharomyces cerevisiae)
Pi [cytosol]
RRAGC,D hydrolyzes GTP (Saccharomyces cerevisiae)
Pi [cytosol]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Saccharomyces cerevisiae)
ATP hydrolysis by HSP70 (Saccharomyces cerevisiae)
Pi [cytosol]
Drug ADME (Saccharomyces cerevisiae)
Aspirin ADME (Saccharomyces cerevisiae)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Saccharomyces cerevisiae)
Pi [cytosol]
Paracetamol ADME (Saccharomyces cerevisiae)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Saccharomyces cerevisiae)
Pi [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Saccharomyces cerevisiae)
Pi [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Saccharomyces cerevisiae)
Pi [cytosol]
Immune System (Saccharomyces cerevisiae)
Adaptive Immune System (Saccharomyces cerevisiae)
Regulation of T cell activation by CD28 family (Saccharomyces cerevisiae)
Co-inhibition by CTLA4 (Saccharomyces cerevisiae)
Dephosphorylation of AKT by PP2A (Saccharomyces cerevisiae)
Pi [cytosol]
TCR signaling (Saccharomyces cerevisiae)
Downstream TCR signaling (Saccharomyces cerevisiae)
PTEN dephosphorylates PIP3 (Saccharomyces cerevisiae)
Pi [cytosol]
Innate Immune System (Saccharomyces cerevisiae)
Fcgamma receptor (FCGR) dependent phagocytosis (Saccharomyces cerevisiae)
Role of phospholipids in phagocytosis (Saccharomyces cerevisiae)
Conversion of PA into DAG by PAP-1 (Saccharomyces cerevisiae)
Pi [cytosol]
Metabolism (Saccharomyces cerevisiae)
Biological oxidations (Saccharomyces cerevisiae)
Phase II - Conjugation of compounds (Saccharomyces cerevisiae)
Glutathione conjugation (Saccharomyces cerevisiae)
Glutathione synthesis and recycling (Saccharomyces cerevisiae)
GSS:Mg2+ dimer synthesizes GSH (Saccharomyces cerevisiae)
Pi [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Saccharomyces cerevisiae)
Pi [cytosol]
Methylation (Saccharomyces cerevisiae)
MAT1A multimers transfer Ado from ATP to L-Met (Saccharomyces cerevisiae)
Pi [cytosol]
Inositol phosphate metabolism (Saccharomyces cerevisiae)
Synthesis of IP2, IP, and Ins in the cytosol (Saccharomyces cerevisiae)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Saccharomyces cerevisiae)
Pi [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)
Pi [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)
Pi [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)
Pi [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Saccharomyces cerevisiae)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Saccharomyces cerevisiae)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Saccharomyces cerevisiae)
Pi [cytosol]
Synthesis of pyrophosphates in the cytosol (Saccharomyces cerevisiae)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)
Pi [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)
Pi [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)
Pi [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)
Pi [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Saccharomyces cerevisiae)
Pi [cytosol]
Metabolism of amino acids and derivatives (Saccharomyces cerevisiae)
Glutamate and glutamine metabolism (Saccharomyces cerevisiae)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Saccharomyces cerevisiae)
Pi [cytosol]
Selenoamino acid metabolism (Saccharomyces cerevisiae)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Saccharomyces cerevisiae)
SeMet is converted to AdoSeMet by MAT (Saccharomyces cerevisiae)
Pi [cytosol]
Serine metabolism (Saccharomyces cerevisiae)
<
![Pi [cytosol] icon](/icon/R-ICO-014111.svg){kind=icon}