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About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
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Citing us
Tools
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Analyse gene list
Analyse gene expression
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L-Glu [cytosol]
Stable Identifier
R-ALL-29404
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
L-Glutamate, L-glutamate(1-), L-glutamic acid, L-Glutaminic acid
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Drug ADME (Bos taurus)
Azathioprine ADME (Bos taurus)
GMPS dimer transforms 6TXMP to 6TGMP (Bos taurus)
L-Glu [cytosol]
Paracetamol ADME (Bos taurus)
GGT dimers hydrolyse APAP-SG (Bos taurus)
L-Glu [cytosol]
Metabolism (Bos taurus)
Aerobic respiration and respiratory electron transport (Bos taurus)
Pyruvate metabolism (Bos taurus)
PXLP-K314-GPT transaminates L-Ala to form PYR (Bos taurus)
L-Glu [cytosol]
Respiratory electron transport (Bos taurus)
Malate-aspartate shuttle (Bos taurus)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Bos taurus)
L-Glu [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Bos taurus)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Bos taurus)
L-Glu [cytosol]
Biological oxidations (Bos taurus)
Phase II - Conjugation of compounds (Bos taurus)
Glutathione conjugation (Bos taurus)
Glutathione synthesis and recycling (Bos taurus)
GCL ligates L-Glu to L-Cys (Bos taurus)
L-Glu [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Bos taurus)
L-Glu [cytosol]
Metabolism of amino acids and derivatives (Bos taurus)
Alanine metabolism (Bos taurus)
PXLP-K314-GPT transaminates L-Ala to form PYR (Bos taurus)
L-Glu [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Bos taurus)
L-Glu [cytosol]
Aspartate and asparagine metabolism (Bos taurus)
NAALADases hydrolyse NAAG (Bos taurus)
L-Glu [cytosol]
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Bos taurus)
L-Glu [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Bos taurus)
L-Glu [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Bos taurus)
L-Glu [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Bos taurus)
L-Glu [cytosol]
Branched-chain amino acid catabolism (Bos taurus)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Bos taurus)
L-Glu [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Bos taurus)
L-Glu [cytosol]
Glutamate and glutamine metabolism (Bos taurus)
N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Bos taurus)
L-Glu [cytosol]
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Bos taurus)
L-Glu [cytosol]
Histidine catabolism (Bos taurus)
N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Bos taurus)
L-Glu [cytosol]
Phenylalanine and tyrosine metabolism (Bos taurus)
Tyrosine catabolism (Bos taurus)
TAT aminates HPP (Bos taurus)
L-Glu [cytosol]
TAT deaminates tyrosine (Bos taurus)
L-Glu [cytosol]
Serine biosynthesis (Bos taurus)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Bos taurus)
L-Glu [cytosol]
Metabolism of nucleotides (Bos taurus)
Interconversion of nucleotide di- and triphosphates (Bos taurus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Bos taurus)
L-Glu [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Bos taurus)
L-Glu [cytosol]
Nucleotide biosynthesis (Bos taurus)
Purine ribonucleoside monophosphate biosynthesis (Bos taurus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Bos taurus)
L-Glu [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Bos taurus)
L-Glu [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Bos taurus)
L-Glu [cytosol]
Pyrimidine biosynthesis (Bos taurus)
CAD hexamer transforms L-Gln to CAP (Bos taurus)
L-Glu [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Metabolism of folate and pterines (Bos taurus)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Bos taurus)
L-Glu [cytosol]
FPGS-2 transforms THF to THFPG (Bos taurus)
L-Glu [cytosol]
Nicotinate metabolism (Bos taurus)
NADSYN1 hexamer amidates NAAD to NAD+ (Bos taurus)
L-Glu [cytosol]
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Asparagine N-linked glycosylation (Bos taurus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Bos taurus)
Synthesis of substrates in N-glycan biosythesis (Bos taurus)
Synthesis of UDP-N-acetyl-glucosamine (Bos taurus)
GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Bos taurus)
L-Glu [cytosol]
Carboxyterminal post-translational modifications of tubulin (Bos taurus)
TTLLs polyglutamylate tubulin (Bos taurus)
L-Glu [cytosol]
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter release cycle (Bos taurus)
GABA synthesis, release, reuptake and degradation (Bos taurus)
GABA synthesis (Bos taurus)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Bos taurus)
L-Glu [cytosol]
Synthesis of GABA by GAD2 (Bos taurus)
L-Glu [cytosol]
Glutamate Neurotransmitter Release Cycle (Bos taurus)
L-Glutamate loading of synaptic vesicle (Bos taurus)
L-Glu [cytosol]
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Bos taurus)
L-Glu [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Bos taurus)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Bos taurus)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Bos taurus)
L-Glu [cytosol]
glutamate uptake by astrocytes (Bos taurus)
L-Glu [cytosol]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Bos taurus)
Amino acid transport across the plasma membrane (Bos taurus)
SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Bos taurus)
L-Glu [cytosol]
Organic anion transporters (Bos taurus)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Bos taurus)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Bos taurus)
L-Glu [cytosol]
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Bos taurus)
L-Glu,L-Asp,D-Asp [cytosol]
L-Glu [cytosol]
Drug ADME (Caenorhabditis elegans)
Azathioprine ADME (Caenorhabditis elegans)
GMPS dimer transforms 6TXMP to 6TGMP (Caenorhabditis elegans)
L-Glu [cytosol]
Paracetamol ADME (Caenorhabditis elegans)
GGT dimers hydrolyse APAP-SG (Caenorhabditis elegans)
L-Glu [cytosol]
Metabolism (Caenorhabditis elegans)
Aerobic respiration and respiratory electron transport (Caenorhabditis elegans)
Pyruvate metabolism (Caenorhabditis elegans)
PXLP-K314-GPT transaminates L-Ala to form PYR (Caenorhabditis elegans)
L-Glu [cytosol]
Respiratory electron transport (Caenorhabditis elegans)
Malate-aspartate shuttle (Caenorhabditis elegans)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Caenorhabditis elegans)
L-Glu [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Caenorhabditis elegans)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Caenorhabditis elegans)
L-Glu [cytosol]
Biological oxidations (Caenorhabditis elegans)
Phase II - Conjugation of compounds (Caenorhabditis elegans)
Glutathione conjugation (Caenorhabditis elegans)
Glutathione synthesis and recycling (Caenorhabditis elegans)
GCL ligates L-Glu to L-Cys (Caenorhabditis elegans)
L-Glu [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Caenorhabditis elegans)
L-Glu [cytosol]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Alanine metabolism (Caenorhabditis elegans)
PXLP-K314-GPT transaminates L-Ala to form PYR (Caenorhabditis elegans)
L-Glu [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Caenorhabditis elegans)
L-Glu [cytosol]
Aspartate and asparagine metabolism (Caenorhabditis elegans)
NAALADases hydrolyse NAAG (Caenorhabditis elegans)
L-Glu [cytosol]
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Caenorhabditis elegans)
L-Glu [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Caenorhabditis elegans)
L-Glu [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Caenorhabditis elegans)
L-Glu [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Caenorhabditis elegans)
L-Glu [cytosol]
Branched-chain amino acid catabolism (Caenorhabditis elegans)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Caenorhabditis elegans)
L-Glu [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Caenorhabditis elegans)
L-Glu [cytosol]
Glutamate and glutamine metabolism (Caenorhabditis elegans)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Caenorhabditis elegans)
L-Glu [cytosol]
Phenylalanine and tyrosine metabolism (Caenorhabditis elegans)
Tyrosine catabolism (Caenorhabditis elegans)
TAT aminates HPP (Caenorhabditis elegans)
L-Glu [cytosol]
TAT deaminates tyrosine (Caenorhabditis elegans)
L-Glu [cytosol]
Serine biosynthesis (Caenorhabditis elegans)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Caenorhabditis elegans)
L-Glu [cytosol]
Metabolism of nucleotides (Caenorhabditis elegans)
Interconversion of nucleotide di- and triphosphates (Caenorhabditis elegans)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Caenorhabditis elegans)
L-Glu [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Caenorhabditis elegans)
L-Glu [cytosol]
Nucleotide biosynthesis (Caenorhabditis elegans)
Purine ribonucleoside monophosphate biosynthesis (Caenorhabditis elegans)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Caenorhabditis elegans)
L-Glu [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Caenorhabditis elegans)
L-Glu [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Caenorhabditis elegans)
L-Glu [cytosol]
Pyrimidine biosynthesis (Caenorhabditis elegans)
CAD hexamer transforms L-Gln to CAP (Caenorhabditis elegans)
L-Glu [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Metabolism of folate and pterines (Caenorhabditis elegans)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Caenorhabditis elegans)
L-Glu [cytosol]
FPGS-2 transforms THF to THFPG (Caenorhabditis elegans)
L-Glu [cytosol]
Nicotinate metabolism (Caenorhabditis elegans)
NADSYN1 hexamer amidates NAAD to NAD+ (Caenorhabditis elegans)
L-Glu [cytosol]
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Asparagine N-linked glycosylation (Caenorhabditis elegans)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Caenorhabditis elegans)
Synthesis of substrates in N-glycan biosythesis (Caenorhabditis elegans)
Synthesis of UDP-N-acetyl-glucosamine (Caenorhabditis elegans)
GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Caenorhabditis elegans)
L-Glu [cytosol]
Neuronal System (Caenorhabditis elegans)
Transmission across Chemical Synapses (Caenorhabditis elegans)
Neurotransmitter release cycle (Caenorhabditis elegans)
GABA synthesis, release, reuptake and degradation (Caenorhabditis elegans)
GABA synthesis (Caenorhabditis elegans)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Caenorhabditis elegans)
L-Glu [cytosol]
Synthesis of GABA by GAD2 (Caenorhabditis elegans)
L-Glu [cytosol]
Glutamate Neurotransmitter Release Cycle (Caenorhabditis elegans)
L-Glutamate loading of synaptic vesicle (Caenorhabditis elegans)
L-Glu [cytosol]
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Caenorhabditis elegans)
L-Glu [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Caenorhabditis elegans)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Caenorhabditis elegans)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Caenorhabditis elegans)
L-Glu [cytosol]
glutamate uptake by astrocytes (Caenorhabditis elegans)
L-Glu [cytosol]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of inorganic cations/anions and amino acids/oligopeptides (Caenorhabditis elegans)
Organic anion transporters (Caenorhabditis elegans)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Caenorhabditis elegans)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Caenorhabditis elegans)
L-Glu [cytosol]
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Caenorhabditis elegans)
L-Glu,L-Asp,D-Asp [cytosol]
L-Glu [cytosol]
Drug ADME (Canis familiaris)
Azathioprine ADME (Canis familiaris)
GMPS dimer transforms 6TXMP to 6TGMP (Canis familiaris)
L-Glu [cytosol]
Paracetamol ADME (Canis familiaris)
GGT dimers hydrolyse APAP-SG (Canis familiaris)
L-Glu [cytosol]
Metabolism (Canis familiaris)
Aerobic respiration and respiratory electron transport (Canis familiaris)
Pyruvate metabolism (Canis familiaris)
PXLP-K314-GPT transaminates L-Ala to form PYR (Canis familiaris)
L-Glu [cytosol]
Respiratory electron transport (Canis familiaris)
Malate-aspartate shuttle (Canis familiaris)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Canis familiaris)
L-Glu [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Canis familiaris)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Canis familiaris)
L-Glu [cytosol]
Biological oxidations (Canis familiaris)
Phase II - Conjugation of compounds (Canis familiaris)
Glutathione conjugation (Canis familiaris)
Glutathione synthesis and recycling (Canis familiaris)
GCL ligates L-Glu to L-Cys (Canis familiaris)
L-Glu [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Canis familiaris)
L-Glu [cytosol]
Metabolism of amino acids and derivatives (Canis familiaris)
Alanine metabolism (Canis familiaris)
PXLP-K314-GPT transaminates L-Ala to form PYR (Canis familiaris)
L-Glu [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Canis familiaris)
L-Glu [cytosol]
Aspartate and asparagine metabolism (Canis familiaris)
NAALADases hydrolyse NAAG (Canis familiaris)
L-Glu [cytosol]
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Canis familiaris)
L-Glu [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Canis familiaris)
L-Glu [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Canis familiaris)
L-Glu [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Canis familiaris)
L-Glu [cytosol]
Branched-chain amino acid catabolism (Canis familiaris)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Canis familiaris)
L-Glu [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Canis familiaris)
L-Glu [cytosol]
Glutamate and glutamine metabolism (Canis familiaris)
N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Canis familiaris)
L-Glu [cytosol]
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Canis familiaris)
L-Glu [cytosol]
Histidine catabolism (Canis familiaris)
N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Canis familiaris)
L-Glu [cytosol]
Phenylalanine and tyrosine metabolism (Canis familiaris)
Tyrosine catabolism (Canis familiaris)
TAT aminates HPP (Canis familiaris)
L-Glu [cytosol]
TAT deaminates tyrosine (Canis familiaris)
L-Glu [cytosol]
Serine biosynthesis (Canis familiaris)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Canis familiaris)
L-Glu [cytosol]
Metabolism of nucleotides (Canis familiaris)
Interconversion of nucleotide di- and triphosphates (Canis familiaris)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Canis familiaris)
L-Glu [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Canis familiaris)
L-Glu [cytosol]
Nucleotide biosynthesis (Canis familiaris)
Purine ribonucleoside monophosphate biosynthesis (Canis familiaris)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Canis familiaris)
L-Glu [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Canis familiaris)
L-Glu [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Canis familiaris)
L-Glu [cytosol]
Pyrimidine biosynthesis (Canis familiaris)
CAD hexamer transforms L-Gln to CAP (Canis familiaris)
L-Glu [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Metabolism of folate and pterines (Canis familiaris)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Canis familiaris)
L-Glu [cytosol]
FPGS-2 transforms THF to THFPG (Canis familiaris)
L-Glu [cytosol]
Nicotinate metabolism (Canis familiaris)
NADSYN1 hexamer amidates NAAD to NAD+ (Canis familiaris)
L-Glu [cytosol]
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Asparagine N-linked glycosylation (Canis familiaris)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Canis familiaris)
Synthesis of substrates in N-glycan biosythesis (Canis familiaris)
Synthesis of UDP-N-acetyl-glucosamine (Canis familiaris)
GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Canis familiaris)
L-Glu [cytosol]
Carboxyterminal post-translational modifications of tubulin (Canis familiaris)
TTLLs polyglutamylate tubulin (Canis familiaris)
L-Glu [cytosol]
Neuronal System (Canis familiaris)
Transmission across Chemical Synapses (Canis familiaris)
Neurotransmitter release cycle (Canis familiaris)
GABA synthesis, release, reuptake and degradation (Canis familiaris)
GABA synthesis (Canis familiaris)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Canis familiaris)
L-Glu [cytosol]
Synthesis of GABA by GAD2 (Canis familiaris)
L-Glu [cytosol]
Glutamate Neurotransmitter Release Cycle (Canis familiaris)
L-Glutamate loading of synaptic vesicle (Canis familiaris)
L-Glu [cytosol]
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Canis familiaris)
L-Glu [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Canis familiaris)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Canis familiaris)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Canis familiaris)
L-Glu [cytosol]
glutamate uptake by astrocytes (Canis familiaris)
L-Glu [cytosol]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
Transport of inorganic cations/anions and amino acids/oligopeptides (Canis familiaris)
Amino acid transport across the plasma membrane (Canis familiaris)
SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Canis familiaris)
L-Glu [cytosol]
Organic anion transporters (Canis familiaris)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Canis familiaris)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Canis familiaris)
L-Glu [cytosol]
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Canis familiaris)
L-Glu,L-Asp,D-Asp [cytosol]
L-Glu [cytosol]
Metabolism (Danio rerio)
Aerobic respiration and respiratory electron transport (Danio rerio)
Pyruvate metabolism (Danio rerio)
PXLP-K314-GPT transaminates L-Ala to form PYR (Danio rerio)
L-Glu [cytosol]
Respiratory electron transport (Danio rerio)
Malate-aspartate shuttle (Danio rerio)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Danio rerio)
L-Glu [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Danio rerio)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Danio rerio)
L-Glu [cytosol]
Biological oxidations (Danio rerio)
Phase II - Conjugation of compounds (Danio rerio)
Glutathione conjugation (Danio rerio)
Glutathione synthesis and recycling (Danio rerio)
OPLAH hydrolyses OPRO to L-Glu (Danio rerio)
L-Glu [cytosol]
Metabolism of amino acids and derivatives (Danio rerio)
Alanine metabolism (Danio rerio)
PXLP-K314-GPT transaminates L-Ala to form PYR (Danio rerio)
L-Glu [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Danio rerio)
L-Glu [cytosol]
Aspartate and asparagine metabolism (Danio rerio)
NAALADases hydrolyse NAAG (Danio rerio)
L-Glu [cytosol]
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Danio rerio)
L-Glu [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Danio rerio)
L-Glu [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Danio rerio)
L-Glu [cytosol]
Branched-chain amino acid catabolism (Danio rerio)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Danio rerio)
L-Glu [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Danio rerio)
L-Glu [cytosol]
Glutamate and glutamine metabolism (Danio rerio)
N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Danio rerio)
L-Glu [cytosol]
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Danio rerio)
L-Glu [cytosol]
Phenylalanine and tyrosine metabolism (Danio rerio)
Tyrosine catabolism (Danio rerio)
TAT aminates HPP (Danio rerio)
L-Glu [cytosol]
TAT deaminates tyrosine (Danio rerio)
L-Glu [cytosol]
Serine biosynthesis (Danio rerio)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Danio rerio)
L-Glu [cytosol]
Metabolism of nucleotides (Danio rerio)
Interconversion of nucleotide di- and triphosphates (Danio rerio)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Danio rerio)
L-Glu [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Danio rerio)
L-Glu [cytosol]
Nucleotide biosynthesis (Danio rerio)
Purine ribonucleoside monophosphate biosynthesis (Danio rerio)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Danio rerio)
L-Glu [cytosol]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Metabolism of folate and pterines (Danio rerio)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Danio rerio)
L-Glu [cytosol]
FPGS-2 transforms THF to THFPG (Danio rerio)
L-Glu [cytosol]
Nicotinate metabolism (Danio rerio)
NADSYN1 hexamer amidates NAAD to NAD+ (Danio rerio)
L-Glu [cytosol]
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Asparagine N-linked glycosylation (Danio rerio)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Danio rerio)
Synthesis of substrates in N-glycan biosythesis (Danio rerio)
Synthesis of UDP-N-acetyl-glucosamine (Danio rerio)
GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Danio rerio)
L-Glu [cytosol]
Neuronal System (Danio rerio)
Transmission across Chemical Synapses (Danio rerio)
Neurotransmitter release cycle (Danio rerio)
GABA synthesis, release, reuptake and degradation (Danio rerio)
GABA synthesis (Danio rerio)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Danio rerio)
L-Glu [cytosol]
Glutamate Neurotransmitter Release Cycle (Danio rerio)
L-Glutamate loading of synaptic vesicle (Danio rerio)
L-Glu [cytosol]
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Danio rerio)
L-Glu [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Danio rerio)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Danio rerio)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Danio rerio)
L-Glu [cytosol]
glutamate uptake by astrocytes (Danio rerio)
L-Glu [cytosol]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
Transport of inorganic cations/anions and amino acids/oligopeptides (Danio rerio)
Organic anion transporters (Danio rerio)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Danio rerio)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Danio rerio)
L-Glu [cytosol]
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Danio rerio)
L-Glu,L-Asp,D-Asp [cytosol]
L-Glu [cytosol]
Drug ADME (Dictyostelium discoideum)
Azathioprine ADME (Dictyostelium discoideum)
GMPS dimer transforms 6TXMP to 6TGMP (Dictyostelium discoideum)
L-Glu [cytosol]
Metabolism (Dictyostelium discoideum)
Aerobic respiration and respiratory electron transport (Dictyostelium discoideum)
Pyruvate metabolism (Dictyostelium discoideum)
PXLP-K314-GPT transaminates L-Ala to form PYR (Dictyostelium discoideum)
L-Glu [cytosol]
Respiratory electron transport (Dictyostelium discoideum)
Malate-aspartate shuttle (Dictyostelium discoideum)
SLC25A12,13 exchange L-Glu and L-Asp (Dictyostelium discoideum)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Dictyostelium discoideum)
L-Glu [cytosol]
Biological oxidations (Dictyostelium discoideum)
Phase II - Conjugation of compounds (Dictyostelium discoideum)
Glutathione conjugation (Dictyostelium discoideum)
Glutathione synthesis and recycling (Dictyostelium discoideum)
OPLAH hydrolyses OPRO to L-Glu (Dictyostelium discoideum)
L-Glu [cytosol]
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Alanine metabolism (Dictyostelium discoideum)
PXLP-K314-GPT transaminates L-Ala to form PYR (Dictyostelium discoideum)
L-Glu [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Dictyostelium discoideum)
L-Glu [cytosol]
Aspartate and asparagine metabolism (Dictyostelium discoideum)
SLC25A12,13 exchange L-Glu and L-Asp (Dictyostelium discoideum)
L-Glu [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Dictyostelium discoideum)
L-Glu [cytosol]
Branched-chain amino acid catabolism (Dictyostelium discoideum)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Dictyostelium discoideum)
L-Glu [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Dictyostelium discoideum)
L-Glu [cytosol]
Histidine catabolism (Dictyostelium discoideum)
N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Dictyostelium discoideum)
L-Glu [cytosol]
Phenylalanine and tyrosine metabolism (Dictyostelium discoideum)
Tyrosine catabolism (Dictyostelium discoideum)
TAT aminates HPP (Dictyostelium discoideum)
L-Glu [cytosol]
TAT deaminates tyrosine (Dictyostelium discoideum)
L-Glu [cytosol]
Serine biosynthesis (Dictyostelium discoideum)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Dictyostelium discoideum)
L-Glu [cytosol]
Metabolism of nucleotides (Dictyostelium discoideum)
Interconversion of nucleotide di- and triphosphates (Dictyostelium discoideum)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Dictyostelium discoideum)
L-Glu [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Dictyostelium discoideum)
L-Glu [cytosol]
Nucleotide biosynthesis (Dictyostelium discoideum)
Purine ribonucleoside monophosphate biosynthesis (Dictyostelium discoideum)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Dictyostelium discoideum)
L-Glu [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Dictyostelium discoideum)
L-Glu [cytosol]
Pyrimidine biosynthesis (Dictyostelium discoideum)
CAD hexamer transforms L-Gln to CAP (Dictyostelium discoideum)
L-Glu [cytosol]
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of water-soluble vitamins and cofactors (Dictyostelium discoideum)
Metabolism of folate and pterines (Dictyostelium discoideum)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Dictyostelium discoideum)
L-Glu [cytosol]
FPGS-2 transforms THF to THFPG (Dictyostelium discoideum)
L-Glu [cytosol]
Nicotinate metabolism (Dictyostelium discoideum)
NADSYN1 hexamer amidates NAAD to NAD+ (Dictyostelium discoideum)
L-Glu [cytosol]
Metabolism of proteins (Dictyostelium discoideum)
Post-translational protein modification (Dictyostelium discoideum)
Asparagine N-linked glycosylation (Dictyostelium discoideum)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Dictyostelium discoideum)
Synthesis of substrates in N-glycan biosythesis (Dictyostelium discoideum)
Synthesis of UDP-N-acetyl-glucosamine (Dictyostelium discoideum)
GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Dictyostelium discoideum)
L-Glu [cytosol]
Neuronal System (Dictyostelium discoideum)
Transmission across Chemical Synapses (Dictyostelium discoideum)
Neurotransmitter release cycle (Dictyostelium discoideum)
Glutamate Neurotransmitter Release Cycle (Dictyostelium discoideum)
L-Glutamate loading of synaptic vesicle (Dictyostelium discoideum)
L-Glu [cytosol]
Transport of small molecules (Dictyostelium discoideum)
SLC-mediated transmembrane transport (Dictyostelium discoideum)
Transport of inorganic cations/anions and amino acids/oligopeptides (Dictyostelium discoideum)
Organic anion transporters (Dictyostelium discoideum)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Dictyostelium discoideum)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Dictyostelium discoideum)
L-Glu [cytosol]
Drug ADME (Drosophila melanogaster)
Azathioprine ADME (Drosophila melanogaster)
GMPS dimer transforms 6TXMP to 6TGMP (Drosophila melanogaster)
L-Glu [cytosol]
Paracetamol ADME (Drosophila melanogaster)
GGT dimers hydrolyse APAP-SG (Drosophila melanogaster)
L-Glu [cytosol]
Metabolism (Drosophila melanogaster)
Aerobic respiration and respiratory electron transport (Drosophila melanogaster)
Pyruvate metabolism (Drosophila melanogaster)
PXLP-K314-GPT transaminates L-Ala to form PYR (Drosophila melanogaster)
L-Glu [cytosol]
Respiratory electron transport (Drosophila melanogaster)
Malate-aspartate shuttle (Drosophila melanogaster)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Drosophila melanogaster)
L-Glu [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Drosophila melanogaster)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Drosophila melanogaster)
L-Glu [cytosol]
Biological oxidations (Drosophila melanogaster)
Phase II - Conjugation of compounds (Drosophila melanogaster)
Glutathione conjugation (Drosophila melanogaster)
Glutathione synthesis and recycling (Drosophila melanogaster)
GCL ligates L-Glu to L-Cys (Drosophila melanogaster)
L-Glu [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Drosophila melanogaster)
L-Glu [cytosol]
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Alanine metabolism (Drosophila melanogaster)
PXLP-K314-GPT transaminates L-Ala to form PYR (Drosophila melanogaster)
L-Glu [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Drosophila melanogaster)
L-Glu [cytosol]
Aspartate and asparagine metabolism (Drosophila melanogaster)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Drosophila melanogaster)
L-Glu [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Drosophila melanogaster)
L-Glu [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Drosophila melanogaster)
L-Glu [cytosol]
Branched-chain amino acid catabolism (Drosophila melanogaster)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Drosophila melanogaster)
L-Glu [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Drosophila melanogaster)
L-Glu [cytosol]
Glutamate and glutamine metabolism (Drosophila melanogaster)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Drosophila melanogaster)
L-Glu [cytosol]
Phenylalanine and tyrosine metabolism (Drosophila melanogaster)
Tyrosine catabolism (Drosophila melanogaster)
TAT aminates HPP (Drosophila melanogaster)
L-Glu [cytosol]
TAT deaminates tyrosine (Drosophila melanogaster)
L-Glu [cytosol]
Serine biosynthesis (Drosophila melanogaster)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Drosophila melanogaster)
L-Glu [cytosol]
Metabolism of nucleotides (Drosophila melanogaster)
Interconversion of nucleotide di- and triphosphates (Drosophila melanogaster)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Drosophila melanogaster)
L-Glu [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Drosophila melanogaster)
L-Glu [cytosol]
Nucleotide biosynthesis (Drosophila melanogaster)
Purine ribonucleoside monophosphate biosynthesis (Drosophila melanogaster)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Drosophila melanogaster)
L-Glu [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Drosophila melanogaster)
L-Glu [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Drosophila melanogaster)
L-Glu [cytosol]
Pyrimidine biosynthesis (Drosophila melanogaster)
CAD hexamer transforms L-Gln to CAP (Drosophila melanogaster)
L-Glu [cytosol]
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of water-soluble vitamins and cofactors (Drosophila melanogaster)
Metabolism of folate and pterines (Drosophila melanogaster)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Drosophila melanogaster)
L-Glu [cytosol]
FPGS-2 transforms THF to THFPG (Drosophila melanogaster)
L-Glu [cytosol]
Nicotinate metabolism (Drosophila melanogaster)
NADSYN1 hexamer amidates NAAD to NAD+ (Drosophila melanogaster)
L-Glu [cytosol]
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Asparagine N-linked glycosylation (Drosophila melanogaster)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Drosophila melanogaster)
Synthesis of substrates in N-glycan biosythesis (Drosophila melanogaster)
Synthesis of UDP-N-acetyl-glucosamine (Drosophila melanogaster)
GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Drosophila melanogaster)
L-Glu [cytosol]
Neuronal System (Drosophila melanogaster)
Transmission across Chemical Synapses (Drosophila melanogaster)
Neurotransmitter release cycle (Drosophila melanogaster)
GABA synthesis, release, reuptake and degradation (Drosophila melanogaster)
GABA synthesis (Drosophila melanogaster)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Drosophila melanogaster)
L-Glu [cytosol]
Synthesis of GABA by GAD2 (Drosophila melanogaster)
L-Glu [cytosol]
Glutamate Neurotransmitter Release Cycle (Drosophila melanogaster)
L-Glutamate loading of synaptic vesicle (Drosophila melanogaster)
L-Glu [cytosol]
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Drosophila melanogaster)
L-Glu [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Drosophila melanogaster)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Drosophila melanogaster)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Drosophila melanogaster)
L-Glu [cytosol]
glutamate uptake by astrocytes (Drosophila melanogaster)
L-Glu [cytosol]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of inorganic cations/anions and amino acids/oligopeptides (Drosophila melanogaster)
Amino acid transport across the plasma membrane (Drosophila melanogaster)
SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Drosophila melanogaster)
L-Glu [cytosol]
Organic anion transporters (Drosophila melanogaster)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Drosophila melanogaster)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Drosophila melanogaster)
L-Glu [cytosol]
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Drosophila melanogaster)
L-Glu,L-Asp,D-Asp [cytosol]
L-Glu [cytosol]
Drug ADME (Gallus gallus)
Azathioprine ADME (Gallus gallus)
GMPS dimer transforms 6TXMP to 6TGMP (Gallus gallus)
L-Glu [cytosol]
Paracetamol ADME (Gallus gallus)
GGT dimers hydrolyse APAP-SG (Gallus gallus)
L-Glu [cytosol]
Metabolism (Gallus gallus)
Amino acid metabolism (Gallus gallus)
aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate (Gallus gallus)
L-Glu [cytosol]
aspartate [mitochondrial matrix] + glutamate [cytosol] <=> aspartate [cytosol] + glutamate [mitochondrial matrix] (Gallus gallus)
L-Glu [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate) (Gallus gallus)
L-Glu [cytosol]
Carbohydrate metabolism (Gallus gallus)
Gluconeogenesis (Gallus gallus)
aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate (Gallus gallus)
L-Glu [cytosol]
aspartate [mitochondrial matrix] + glutamate [cytosol] <=> aspartate [cytosol] + glutamate [mitochondrial matrix] (Gallus gallus)
L-Glu [cytosol]
Nucleotide metabolism (Gallus gallus)
Purine metabolism (Gallus gallus)
De novo synthesis of GMP (Gallus gallus)
xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate (Gallus gallus)
L-Glu [cytosol]
De novo synthesis of IMP (Gallus gallus)
5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + ADP + orthophosphate (Gallus gallus)
L-Glu [cytosol]
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate + pyrophosphate (Gallus gallus)
L-Glu [cytosol]
Pyrimidine metabolism: de novo synthesis of UMP (Gallus gallus)
L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate (Gallus gallus)
L-Glu [cytosol]
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Asparagine N-linked glycosylation (Gallus gallus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Gallus gallus)
Synthesis of substrates in N-glycan biosythesis (Gallus gallus)
Synthesis of UDP-N-acetyl-glucosamine (Gallus gallus)
GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Gallus gallus)
L-Glu [cytosol]
Neuronal System (Gallus gallus)
Transmission across Chemical Synapses (Gallus gallus)
Neurotransmitter release cycle (Gallus gallus)
GABA synthesis, release, reuptake and degradation (Gallus gallus)
GABA synthesis (Gallus gallus)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Gallus gallus)
L-Glu [cytosol]
Synthesis of GABA by GAD2 (Gallus gallus)
L-Glu [cytosol]
Glutamate Neurotransmitter Release Cycle (Gallus gallus)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Gallus gallus)
L-Glu [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Gallus gallus)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Gallus gallus)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Gallus gallus)
L-Glu [cytosol]
glutamate uptake by astrocytes (Gallus gallus)
L-Glu [cytosol]
Transport of small molecules (Gallus gallus)
SLC-mediated transmembrane transport (Gallus gallus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Gallus gallus)
Organic anion transporters (Gallus gallus)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Gallus gallus)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Gallus gallus)
L-Glu [cytosol]
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Gallus gallus)
L-Glu,L-Asp,D-Asp [cytosol]
L-Glu [cytosol]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Metabolic disorders of biological oxidation enzymes (Homo sapiens)
Defective GCLC causes HAGGSD (Homo sapiens)
Defective GCLC does not ligate L-Glu to L-Cys (Homo sapiens)
L-Glu [cytosol]
Disorders of transmembrane transporters (Homo sapiens)
SLC transporter disorders (Homo sapiens)
Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) (Homo sapiens)
Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+ (Homo sapiens)
L-Glu [cytosol]
Drug ADME (Homo sapiens)
Azathioprine ADME (Homo sapiens)
GMPS dimer transforms 6TXMP to 6TGMP (Homo sapiens)
L-Glu [cytosol]
Paracetamol ADME (Homo sapiens)
GGT dimers hydrolyse APAP-SG (Homo sapiens)
L-Glu [cytosol]
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Pyruvate metabolism (Homo sapiens)
PXLP-K314-GPT transaminates L-Ala to form PYR (Homo sapiens)
L-Glu [cytosol]
Respiratory electron transport (Homo sapiens)
Malate-aspartate shuttle (Homo sapiens)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Homo sapiens)
L-Glu [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Homo sapiens)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Homo sapiens)
L-Glu [cytosol]
Biological oxidations (Homo sapiens)
Phase II - Conjugation of compounds (Homo sapiens)
Glutathione conjugation (Homo sapiens)
Glutathione synthesis and recycling (Homo sapiens)
GCL ligates L-Glu to L-Cys (Homo sapiens)
L-Glu [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Homo sapiens)
L-Glu [cytosol]
Metabolism of amino acids and derivatives (Homo sapiens)
Alanine metabolism (Homo sapiens)
PXLP-K314-GPT transaminates L-Ala to form PYR (Homo sapiens)
L-Glu [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Homo sapiens)
L-Glu [cytosol]
Aspartate and asparagine metabolism (Homo sapiens)
NAALADases hydrolyse NAAG (Homo sapiens)
L-Glu [cytosol]
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Homo sapiens)
L-Glu [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Homo sapiens)
L-Glu [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Homo sapiens)
L-Glu [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Homo sapiens)
L-Glu [cytosol]
Branched-chain amino acid catabolism (Homo sapiens)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Homo sapiens)
L-Glu [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Homo sapiens)
L-Glu [cytosol]
Glutamate and glutamine metabolism (Homo sapiens)
N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Homo sapiens)
L-Glu [cytosol]
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Homo sapiens)
L-Glu [cytosol]
Histidine catabolism (Homo sapiens)
N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Homo sapiens)
L-Glu [cytosol]
Phenylalanine and tyrosine metabolism (Homo sapiens)
Tyrosine catabolism (Homo sapiens)
TAT aminates HPP (Homo sapiens)
L-Glu [cytosol]
TAT deaminates tyrosine (Homo sapiens)
L-Glu [cytosol]
Serine biosynthesis (Homo sapiens)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Homo sapiens)
L-Glu [cytosol]
Metabolism of lipids (Homo sapiens)
Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
Biosynthesis of DHA-derived SPMs (Homo sapiens)
Biosynthesis of DHA-derived sulfido conjugates (Homo sapiens)
Biosynthesis of maresin conjugates in tissue regeneration (MCTR) (Homo sapiens)
GGT hydrolyses MCTR1 to MCTR2 (Homo sapiens)
L-Glu [cytosol]
Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) (Homo sapiens)
GGT hydrolyses PCTR1 to PCTR2 (Homo sapiens)
L-Glu [cytosol]
GGT hydrolyses RCTR1 to RCTR2 (Homo sapiens)
L-Glu [cytosol]
Fatty acid metabolism (Homo sapiens)
Arachidonic acid metabolism (Homo sapiens)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Homo sapiens)
EXC4 is converted to EXD4 by GGT (Homo sapiens)
L-Glu [cytosol]
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Homo sapiens)
L-Glu [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Homo sapiens)
L-Glu [cytosol]
Nucleotide biosynthesis (Homo sapiens)
Purine ribonucleoside monophosphate biosynthesis (Homo sapiens)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Homo sapiens)
L-Glu [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Homo sapiens)
L-Glu [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Homo sapiens)
L-Glu [cytosol]
Pyrimidine biosynthesis (Homo sapiens)
CAD hexamer transforms L-Gln to CAP (Homo sapiens)
L-Glu [cytosol]
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Metabolism of folate and pterines (Homo sapiens)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Homo sapiens)
L-Glu [cytosol]
FPGS-2 transforms THF to THFPG (Homo sapiens)
L-Glu [cytosol]
Nicotinate metabolism (Homo sapiens)
NADSYN1 hexamer amidates NAAD to NAD+ (Homo sapiens)
L-Glu [cytosol]
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
Synthesis of UDP-N-acetyl-glucosamine (Homo sapiens)
GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Homo sapiens)
L-Glu [cytosol]
Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
CCPs deglutamylate tubulin (Homo sapiens)
L-Glu [cytosol]
Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)
L-Glu [cytosol]
TTLLs polyglutamylate tubulin (Homo sapiens)
L-Glu [cytosol]
Translation (Homo sapiens)
tRNA Aminoacylation (Homo sapiens)
Cytosolic tRNA aminoacylation (Homo sapiens)
glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)
L-Glu [cytosol]
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
GABA synthesis, release, reuptake and degradation (Homo sapiens)
GABA synthesis (Homo sapiens)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Homo sapiens)
L-Glu [cytosol]
Synthesis of GABA by GAD2 (Homo sapiens)
L-Glu [cytosol]
Glutamate Neurotransmitter Release Cycle (Homo sapiens)
L-Glutamate loading of synaptic vesicle (Homo sapiens)
L-Glu [cytosol]
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Homo sapiens)
L-Glu [cytosol]
Tranport of L-Glutamate (mitochondrial matrix) to cytosol (Homo sapiens)
L-Glu [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Homo sapiens)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Homo sapiens)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Homo sapiens)
L-Glu [cytosol]
glutamate uptake by astrocytes (Homo sapiens)
L-Glu [cytosol]
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Amino acid transport across the plasma membrane (Homo sapiens)
SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Homo sapiens)
L-Glu [cytosol]
Organic anion transporters (Homo sapiens)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Homo sapiens)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Homo sapiens)
L-Glu [cytosol]
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)
L-Glu,L-Asp,D-Asp [cytosol]
L-Glu [cytosol]
Drug ADME (Mus musculus)
Azathioprine ADME (Mus musculus)
GMPS dimer transforms 6TXMP to 6TGMP (Mus musculus)
L-Glu [cytosol]
Paracetamol ADME (Mus musculus)
GGT dimers hydrolyse APAP-SG (Mus musculus)
L-Glu [cytosol]
Metabolism (Mus musculus)
Aerobic respiration and respiratory electron transport (Mus musculus)
Pyruvate metabolism (Mus musculus)
PXLP-K314-GPT transaminates L-Ala to form PYR (Mus musculus)
L-Glu [cytosol]
Respiratory electron transport (Mus musculus)
Malate-aspartate shuttle (Mus musculus)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Mus musculus)
L-Glu [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Mus musculus)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Mus musculus)
L-Glu [cytosol]
Biological oxidations (Mus musculus)
Phase II - Conjugation of compounds (Mus musculus)
Glutathione conjugation (Mus musculus)
Glutathione synthesis and recycling (Mus musculus)
GCL ligates L-Glu to L-Cys (Mus musculus)
L-Glu [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Mus musculus)
L-Glu [cytosol]
Metabolism of amino acids and derivatives (Mus musculus)
Alanine metabolism (Mus musculus)
PXLP-K314-GPT transaminates L-Ala to form PYR (Mus musculus)
L-Glu [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Mus musculus)
L-Glu [cytosol]
Aspartate and asparagine metabolism (Mus musculus)
NAALADases hydrolyse NAAG (Mus musculus)
L-Glu [cytosol]
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Mus musculus)
L-Glu [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Mus musculus)
L-Glu [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Mus musculus)
L-Glu [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Mus musculus)
L-Glu [cytosol]
Branched-chain amino acid catabolism (Mus musculus)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Mus musculus)
L-Glu [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Mus musculus)
L-Glu [cytosol]
Glutamate and glutamine metabolism (Mus musculus)
N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Mus musculus)
L-Glu [cytosol]
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Mus musculus)
L-Glu [cytosol]
Histidine catabolism (Mus musculus)
N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Mus musculus)
L-Glu [cytosol]
Phenylalanine and tyrosine metabolism (Mus musculus)
Tyrosine catabolism (Mus musculus)
TAT aminates HPP (Mus musculus)
L-Glu [cytosol]
TAT deaminates tyrosine (Mus musculus)
L-Glu [cytosol]
Serine biosynthesis (Mus musculus)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Mus musculus)
L-Glu [cytosol]
Metabolism of nucleotides (Mus musculus)
Interconversion of nucleotide di- and triphosphates (Mus musculus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Mus musculus)
L-Glu [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Mus musculus)
L-Glu [cytosol]
Nucleotide biosynthesis (Mus musculus)
Purine ribonucleoside monophosphate biosynthesis (Mus musculus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Mus musculus)
L-Glu [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Mus musculus)
L-Glu [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Mus musculus)
L-Glu [cytosol]
Pyrimidine biosynthesis (Mus musculus)
CAD hexamer transforms L-Gln to CAP (Mus musculus)
L-Glu [cytosol]
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of water-soluble vitamins and cofactors (Mus musculus)
Metabolism of folate and pterines (Mus musculus)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Mus musculus)
L-Glu [cytosol]
FPGS-2 transforms THF to THFPG (Mus musculus)
L-Glu [cytosol]
Nicotinate metabolism (Mus musculus)
NADSYN1 hexamer amidates NAAD to NAD+ (Mus musculus)
L-Glu [cytosol]
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Asparagine N-linked glycosylation (Mus musculus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Mus musculus)
Synthesis of substrates in N-glycan biosythesis (Mus musculus)
Synthesis of UDP-N-acetyl-glucosamine (Mus musculus)
GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Mus musculus)
L-Glu [cytosol]
Carboxyterminal post-translational modifications of tubulin (Mus musculus)
TTLLs polyglutamylate tubulin (Mus musculus)
L-Glu [cytosol]
Neuronal System (Mus musculus)
Transmission across Chemical Synapses (Mus musculus)
Neurotransmitter release cycle (Mus musculus)
GABA synthesis, release, reuptake and degradation (Mus musculus)
GABA synthesis (Mus musculus)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Mus musculus)
L-Glu [cytosol]
Synthesis of GABA by GAD2 (Mus musculus)
L-Glu [cytosol]
Glutamate Neurotransmitter Release Cycle (Mus musculus)
L-Glutamate loading of synaptic vesicle (Mus musculus)
L-Glu [cytosol]
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Mus musculus)
L-Glu [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Mus musculus)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Mus musculus)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Mus musculus)
L-Glu [cytosol]
glutamate uptake by astrocytes (Mus musculus)
L-Glu [cytosol]
Transport of small molecules (Mus musculus)
SLC-mediated transmembrane transport (Mus musculus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Mus musculus)
Amino acid transport across the plasma membrane (Mus musculus)
SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Mus musculus)
L-Glu [cytosol]
Organic anion transporters (Mus musculus)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Mus musculus)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Mus musculus)
L-Glu [cytosol]
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Mus musculus)
L-Glu,L-Asp,D-Asp [cytosol]
L-Glu [cytosol]
Drug ADME (Plasmodium falciparum)
Azathioprine ADME (Plasmodium falciparum)
GMPS dimer transforms 6TXMP to 6TGMP (Plasmodium falciparum)
L-Glu [cytosol]
Metabolism (Plasmodium falciparum)
Aerobic respiration and respiratory electron transport (Plasmodium falciparum)
Respiratory electron transport (Plasmodium falciparum)
Malate-aspartate shuttle (Plasmodium falciparum)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Plasmodium falciparum)
L-Glu [cytosol]
Metabolism of amino acids and derivatives (Plasmodium falciparum)
Aspartate and asparagine metabolism (Plasmodium falciparum)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Plasmodium falciparum)
L-Glu [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Plasmodium falciparum)
L-Glu [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Plasmodium falciparum)
L-Glu [cytosol]
Metabolism of nucleotides (Plasmodium falciparum)
Interconversion of nucleotide di- and triphosphates (Plasmodium falciparum)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Plasmodium falciparum)
L-Glu [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Plasmodium falciparum)
L-Glu [cytosol]
Nucleotide biosynthesis (Plasmodium falciparum)
Purine ribonucleoside monophosphate biosynthesis (Plasmodium falciparum)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Plasmodium falciparum)
L-Glu [cytosol]
Pyrimidine biosynthesis (Plasmodium falciparum)
CAD hexamer transforms L-Gln to CAP (Plasmodium falciparum)
L-Glu [cytosol]
Metabolism of vitamins and cofactors (Plasmodium falciparum)
Metabolism of water-soluble vitamins and cofactors (Plasmodium falciparum)
Nicotinate metabolism (Plasmodium falciparum)
NADSYN1 hexamer amidates NAAD to NAD+ (Plasmodium falciparum)
L-Glu [cytosol]
Metabolism of proteins (Plasmodium falciparum)
Post-translational protein modification (Plasmodium falciparum)
Asparagine N-linked glycosylation (Plasmodium falciparum)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Plasmodium falciparum)
Synthesis of substrates in N-glycan biosythesis (Plasmodium falciparum)
Synthesis of UDP-N-acetyl-glucosamine (Plasmodium falciparum)
GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Plasmodium falciparum)
L-Glu [cytosol]
Carboxyterminal post-translational modifications of tubulin (Plasmodium falciparum)
TTLLs polyglutamylate tubulin (Plasmodium falciparum)
L-Glu [cytosol]
Drug ADME (Rattus norvegicus)
Azathioprine ADME (Rattus norvegicus)
GMPS dimer transforms 6TXMP to 6TGMP (Rattus norvegicus)
L-Glu [cytosol]
Paracetamol ADME (Rattus norvegicus)
GGT dimers hydrolyse APAP-SG (Rattus norvegicus)
L-Glu [cytosol]
Metabolism (Rattus norvegicus)
Aerobic respiration and respiratory electron transport (Rattus norvegicus)
Pyruvate metabolism (Rattus norvegicus)
PXLP-K314-GPT transaminates L-Ala to form PYR (Rattus norvegicus)
L-Glu [cytosol]
Respiratory electron transport (Rattus norvegicus)
Malate-aspartate shuttle (Rattus norvegicus)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Rattus norvegicus)
L-Glu [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Rattus norvegicus)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Rattus norvegicus)
L-Glu [cytosol]
Biological oxidations (Rattus norvegicus)
Phase II - Conjugation of compounds (Rattus norvegicus)
Glutathione conjugation (Rattus norvegicus)
Glutathione synthesis and recycling (Rattus norvegicus)
GCL ligates L-Glu to L-Cys (Rattus norvegicus)
L-Glu [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Rattus norvegicus)
L-Glu [cytosol]
Metabolism of amino acids and derivatives (Rattus norvegicus)
Alanine metabolism (Rattus norvegicus)
PXLP-K314-GPT transaminates L-Ala to form PYR (Rattus norvegicus)
L-Glu [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Rattus norvegicus)
L-Glu [cytosol]
Aspartate and asparagine metabolism (Rattus norvegicus)
NAALADases hydrolyse NAAG (Rattus norvegicus)
L-Glu [cytosol]
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Rattus norvegicus)
L-Glu [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Rattus norvegicus)
L-Glu [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Rattus norvegicus)
L-Glu [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Rattus norvegicus)
L-Glu [cytosol]
Branched-chain amino acid catabolism (Rattus norvegicus)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Rattus norvegicus)
L-Glu [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Rattus norvegicus)
L-Glu [cytosol]
Glutamate and glutamine metabolism (Rattus norvegicus)
N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Rattus norvegicus)
L-Glu [cytosol]
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Rattus norvegicus)
L-Glu [cytosol]
Histidine catabolism (Rattus norvegicus)
N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Rattus norvegicus)
L-Glu [cytosol]
Phenylalanine and tyrosine metabolism (Rattus norvegicus)
Tyrosine catabolism (Rattus norvegicus)
TAT aminates HPP (Rattus norvegicus)
L-Glu [cytosol]
TAT deaminates tyrosine (Rattus norvegicus)
L-Glu [cytosol]
Serine biosynthesis (Rattus norvegicus)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Rattus norvegicus)
L-Glu [cytosol]
Metabolism of nucleotides (Rattus norvegicus)
Interconversion of nucleotide di- and triphosphates (Rattus norvegicus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Rattus norvegicus)
L-Glu [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Rattus norvegicus)
L-Glu [cytosol]
Nucleotide biosynthesis (Rattus norvegicus)
Purine ribonucleoside monophosphate biosynthesis (Rattus norvegicus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Rattus norvegicus)
L-Glu [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Rattus norvegicus)
L-Glu [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Rattus norvegicus)
L-Glu [cytosol]
Pyrimidine biosynthesis (Rattus norvegicus)
CAD hexamer transforms L-Gln to CAP (Rattus norvegicus)
L-Glu [cytosol]
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of water-soluble vitamins and cofactors (Rattus norvegicus)
Metabolism of folate and pterines (Rattus norvegicus)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Rattus norvegicus)
L-Glu [cytosol]
FPGS-2 transforms THF to THFPG (Rattus norvegicus)
L-Glu [cytosol]
Nicotinate metabolism (Rattus norvegicus)
NADSYN1 hexamer amidates NAAD to NAD+ (Rattus norvegicus)
L-Glu [cytosol]
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Asparagine N-linked glycosylation (Rattus norvegicus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Rattus norvegicus)
Synthesis of substrates in N-glycan biosythesis (Rattus norvegicus)
Synthesis of UDP-N-acetyl-glucosamine (Rattus norvegicus)
GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Rattus norvegicus)
L-Glu [cytosol]
Carboxyterminal post-translational modifications of tubulin (Rattus norvegicus)
TTLLs polyglutamylate tubulin (Rattus norvegicus)
L-Glu [cytosol]
Neuronal System (Rattus norvegicus)
Transmission across Chemical Synapses (Rattus norvegicus)
Neurotransmitter release cycle (Rattus norvegicus)
GABA synthesis, release, reuptake and degradation (Rattus norvegicus)
GABA synthesis (Rattus norvegicus)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Rattus norvegicus)
L-Glu [cytosol]
Synthesis of GABA by GAD2 (Rattus norvegicus)
L-Glu [cytosol]
Glutamate Neurotransmitter Release Cycle (Rattus norvegicus)
L-Glutamate loading of synaptic vesicle (Rattus norvegicus)
L-Glu [cytosol]
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Rattus norvegicus)
L-Glu [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Rattus norvegicus)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Rattus norvegicus)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Rattus norvegicus)
L-Glu [cytosol]
glutamate uptake by astrocytes (Rattus norvegicus)
L-Glu [cytosol]
Transport of small molecules (Rattus norvegicus)
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Rattus norvegicus)
Amino acid transport across the plasma membrane (Rattus norvegicus)
SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Rattus norvegicus)
L-Glu [cytosol]
Organic anion transporters (Rattus norvegicus)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Rattus norvegicus)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Rattus norvegicus)
L-Glu [cytosol]
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Rattus norvegicus)
L-Glu,L-Asp,D-Asp [cytosol]
L-Glu [cytosol]
Drug ADME (Saccharomyces cerevisiae)
Azathioprine ADME (Saccharomyces cerevisiae)
GMPS dimer transforms 6TXMP to 6TGMP (Saccharomyces cerevisiae)
L-Glu [cytosol]
Paracetamol ADME (Saccharomyces cerevisiae)
GGT dimers hydrolyse APAP-SG (Saccharomyces cerevisiae)
L-Glu [cytosol]
Metabolism (Saccharomyces cerevisiae)
Aerobic respiration and respiratory electron transport (Saccharomyces cerevisiae)
Pyruvate metabolism (Saccharomyces cerevisiae)
PXLP-K314-GPT transaminates L-Ala to form PYR (Saccharomyces cerevisiae)
L-Glu [cytosol]
Respiratory electron transport (Saccharomyces cerevisiae)
Malate-aspartate shuttle (Saccharomyces cerevisiae)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Saccharomyces cerevisiae)
L-Glu [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Saccharomyces cerevisiae)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Saccharomyces cerevisiae)
L-Glu [cytosol]
Biological oxidations (Saccharomyces cerevisiae)
Phase II - Conjugation of compounds (Saccharomyces cerevisiae)
Glutathione conjugation (Saccharomyces cerevisiae)
Glutathione synthesis and recycling (Saccharomyces cerevisiae)
OPLAH hydrolyses OPRO to L-Glu (Saccharomyces cerevisiae)
L-Glu [cytosol]
Metabolism of amino acids and derivatives (Saccharomyces cerevisiae)
Alanine metabolism (Saccharomyces cerevisiae)
PXLP-K314-GPT transaminates L-Ala to form PYR (Saccharomyces cerevisiae)
L-Glu [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Saccharomyces cerevisiae)
L-Glu [cytosol]
Aspartate and asparagine metabolism (Saccharomyces cerevisiae)
NAALADases hydrolyse NAAG (Saccharomyces cerevisiae)
L-Glu [cytosol]
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Saccharomyces cerevisiae)
L-Glu [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Saccharomyces cerevisiae)
L-Glu [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Saccharomyces cerevisiae)
L-Glu [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Saccharomyces cerevisiae)
L-Glu [cytosol]
Branched-chain amino acid catabolism (Saccharomyces cerevisiae)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Saccharomyces cerevisiae)
L-Glu [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Saccharomyces cerevisiae)
L-Glu [cytosol]
Glutamate and glutamine metabolism (Saccharomyces cerevisiae)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Saccharomyces cerevisiae)
L-Glu [cytosol]
Serine biosynthesis (Saccharomyces cerevisiae)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Saccharomyces cerevisiae)
L-Glu [cytosol]
Metabolism of nucleotides (Saccharomyces cerevisiae)
Interconversion of nucleotide di- and triphosphates (Saccharomyces cerevisiae)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Saccharomyces cerevisiae)
L-Glu [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Saccharomyces cerevisiae)
L-Glu [cytosol]
Nucleotide biosynthesis (Saccharomyces cerevisiae)
Purine ribonucleoside monophosphate biosynthesis (Saccharomyces cerevisiae)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Saccharomyces cerevisiae)
L-Glu [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Saccharomyces cerevisiae)
L-Glu [cytosol]
Pyrimidine biosynthesis (Saccharomyces cerevisiae)
CAD hexamer transforms L-Gln to CAP (Saccharomyces cerevisiae)
L-Glu [cytosol]
Metabolism of vitamins and cofactors (Saccharomyces cerevisiae)
Metabolism of water-soluble vitamins and cofactors (Saccharomyces cerevisiae)
Metabolism of folate and pterines (Saccharomyces cerevisiae)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Saccharomyces cerevisiae)
L-Glu [cytosol]
FPGS-2 transforms THF to THFPG (Saccharomyces cerevisiae)
L-Glu [cytosol]
Nicotinate metabolism (Saccharomyces cerevisiae)
NADSYN1 hexamer amidates NAAD to NAD+ (Saccharomyces cerevisiae)
L-Glu [cytosol]
Metabolism of proteins (Saccharomyces cerevisiae)
Post-translational protein modification (Saccharomyces cerevisiae)
Asparagine N-linked glycosylation (Saccharomyces cerevisiae)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Saccharomyces cerevisiae)
Synthesis of substrates in N-glycan biosythesis (Saccharomyces cerevisiae)
Synthesis of UDP-N-acetyl-glucosamine (Saccharomyces cerevisiae)
GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Saccharomyces cerevisiae)
L-Glu [cytosol]
Neuronal System (Saccharomyces cerevisiae)
Transmission across Chemical Synapses (Saccharomyces cerevisiae)
Neurotransmitter uptake and metabolism In glial cells (Saccharomyces cerevisiae)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Saccharomyces cerevisiae)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Saccharomyces cerevisiae)
L-Glu [cytosol]
Transport of small molecules (Saccharomyces cerevisiae)
SLC-mediated transmembrane transport (Saccharomyces cerevisiae)
Transport of inorganic cations/anions and amino acids/oligopeptides (Saccharomyces cerevisiae)
Organic anion transporters (Saccharomyces cerevisiae)
SLC25A18,22 import L-Glu, H+ (Saccharomyces cerevisiae)
L-Glu [cytosol]
Drug ADME (Schizosaccharomyces pombe)
Azathioprine ADME (Schizosaccharomyces pombe)
GMPS dimer transforms 6TXMP to 6TGMP (Schizosaccharomyces pombe)
L-Glu [cytosol]
Paracetamol ADME (Schizosaccharomyces pombe)
GGT dimers hydrolyse APAP-SG (Schizosaccharomyces pombe)
L-Glu [cytosol]
Metabolism (Schizosaccharomyces pombe)
Aerobic respiration and respiratory electron transport (Schizosaccharomyces pombe)
Respiratory electron transport (Schizosaccharomyces pombe)
Malate-aspartate shuttle (Schizosaccharomyces pombe)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Schizosaccharomyces pombe)
L-Glu [cytosol]
Biological oxidations (Schizosaccharomyces pombe)
Phase II - Conjugation of compounds (Schizosaccharomyces pombe)
Glutathione conjugation (Schizosaccharomyces pombe)
Glutathione synthesis and recycling (Schizosaccharomyces pombe)
GCL ligates L-Glu to L-Cys (Schizosaccharomyces pombe)
L-Glu [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Schizosaccharomyces pombe)
L-Glu [cytosol]
Metabolism of amino acids and derivatives (Schizosaccharomyces pombe)
Aspartate and asparagine metabolism (Schizosaccharomyces pombe)
NAALADases hydrolyse NAAG (Schizosaccharomyces pombe)
L-Glu [cytosol]
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Schizosaccharomyces pombe)
L-Glu [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Schizosaccharomyces pombe)
L-Glu [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Schizosaccharomyces pombe)
L-Glu [cytosol]
Branched-chain amino acid catabolism (Schizosaccharomyces pombe)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Schizosaccharomyces pombe)
L-Glu [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Schizosaccharomyces pombe)
L-Glu [cytosol]
Glutamate and glutamine metabolism (Schizosaccharomyces pombe)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Schizosaccharomyces pombe)
L-Glu [cytosol]
Serine biosynthesis (Schizosaccharomyces pombe)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Schizosaccharomyces pombe)
L-Glu [cytosol]
Metabolism of nucleotides (Schizosaccharomyces pombe)
Interconversion of nucleotide di- and triphosphates (Schizosaccharomyces pombe)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Schizosaccharomyces pombe)
L-Glu [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Schizosaccharomyces pombe)
L-Glu [cytosol]
Nucleotide biosynthesis (Schizosaccharomyces pombe)
Purine ribonucleoside monophosphate biosynthesis (Schizosaccharomyces pombe)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Schizosaccharomyces pombe)
L-Glu [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Schizosaccharomyces pombe)
L-Glu [cytosol]
Pyrimidine biosynthesis (Schizosaccharomyces pombe)
CAD hexamer transforms L-Gln to CAP (Schizosaccharomyces pombe)
L-Glu [cytosol]
Metabolism of vitamins and cofactors (Schizosaccharomyces pombe)
Metabolism of water-soluble vitamins and cofactors (Schizosaccharomyces pombe)
Metabolism of folate and pterines (Schizosaccharomyces pombe)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Schizosaccharomyces pombe)
L-Glu [cytosol]
FPGS-2 transforms THF to THFPG (Schizosaccharomyces pombe)
L-Glu [cytosol]
Nicotinate metabolism (Schizosaccharomyces pombe)
NADSYN1 hexamer amidates NAAD to NAD+ (Schizosaccharomyces pombe)
L-Glu [cytosol]
Metabolism of proteins (Schizosaccharomyces pombe)
Post-translational protein modification (Schizosaccharomyces pombe)
Asparagine N-linked glycosylation (Schizosaccharomyces pombe)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Schizosaccharomyces pombe)
Synthesis of substrates in N-glycan biosythesis (Schizosaccharomyces pombe)
Synthesis of UDP-N-acetyl-glucosamine (Schizosaccharomyces pombe)
GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Schizosaccharomyces pombe)
L-Glu [cytosol]
Neuronal System (Schizosaccharomyces pombe)
Transmission across Chemical Synapses (Schizosaccharomyces pombe)
Neurotransmitter uptake and metabolism In glial cells (Schizosaccharomyces pombe)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Schizosaccharomyces pombe)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Schizosaccharomyces pombe)
L-Glu [cytosol]
Drug ADME (Sus scrofa)
Azathioprine ADME (Sus scrofa)
GMPS dimer transforms 6TXMP to 6TGMP (Sus scrofa)
L-Glu [cytosol]
Paracetamol ADME (Sus scrofa)
GGT dimers hydrolyse APAP-SG (Sus scrofa)
L-Glu [cytosol]
Metabolism (Sus scrofa)
Aerobic respiration and respiratory electron transport (Sus scrofa)
Pyruvate metabolism (Sus scrofa)
PXLP-K314-GPT transaminates L-Ala to form PYR (Sus scrofa)
L-Glu [cytosol]
Respiratory electron transport (Sus scrofa)
Malate-aspartate shuttle (Sus scrofa)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Sus scrofa)
L-Glu [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Sus scrofa)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Sus scrofa)
L-Glu [cytosol]
Biological oxidations (Sus scrofa)
Phase II - Conjugation of compounds (Sus scrofa)
Glutathione conjugation (Sus scrofa)
Glutathione synthesis and recycling (Sus scrofa)
GCL ligates L-Glu to L-Cys (Sus scrofa)
L-Glu [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Sus scrofa)
L-Glu [cytosol]
Metabolism of amino acids and derivatives (Sus scrofa)
Alanine metabolism (Sus scrofa)
PXLP-K314-GPT transaminates L-Ala to form PYR (Sus scrofa)
L-Glu [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Sus scrofa)
L-Glu [cytosol]
Aspartate and asparagine metabolism (Sus scrofa)
NAALADases hydrolyse NAAG (Sus scrofa)
L-Glu [cytosol]
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Sus scrofa)
L-Glu [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Sus scrofa)
L-Glu [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Sus scrofa)
L-Glu [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Sus scrofa)
L-Glu [cytosol]
Branched-chain amino acid catabolism (Sus scrofa)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Sus scrofa)
L-Glu [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Sus scrofa)
L-Glu [cytosol]
Glutamate and glutamine metabolism (Sus scrofa)
N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Sus scrofa)
L-Glu [cytosol]
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Sus scrofa)
L-Glu [cytosol]
Histidine catabolism (Sus scrofa)
N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Sus scrofa)
L-Glu [cytosol]
Phenylalanine and tyrosine metabolism (Sus scrofa)
Tyrosine catabolism (Sus scrofa)
TAT aminates HPP (Sus scrofa)
L-Glu [cytosol]
TAT deaminates tyrosine (Sus scrofa)
L-Glu [cytosol]
Serine biosynthesis (Sus scrofa)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Sus scrofa)
L-Glu [cytosol]
Metabolism of nucleotides (Sus scrofa)
Interconversion of nucleotide di- and triphosphates (Sus scrofa)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Sus scrofa)
L-Glu [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Sus scrofa)
L-Glu [cytosol]
Nucleotide biosynthesis (Sus scrofa)
Purine ribonucleoside monophosphate biosynthesis (Sus scrofa)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Sus scrofa)
L-Glu [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Sus scrofa)
L-Glu [cytosol]
Pyrimidine biosynthesis (Sus scrofa)
CAD hexamer transforms L-Gln to CAP (Sus scrofa)
L-Glu [cytosol]
Metabolism of vitamins and cofactors (Sus scrofa)
Metabolism of water-soluble vitamins and cofactors (Sus scrofa)
Metabolism of folate and pterines (Sus scrofa)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Sus scrofa)
L-Glu [cytosol]
FPGS-2 transforms THF to THFPG (Sus scrofa)
L-Glu [cytosol]
Nicotinate metabolism (Sus scrofa)
NADSYN1 hexamer amidates NAAD to NAD+ (Sus scrofa)
L-Glu [cytosol]
Metabolism of proteins (Sus scrofa)
Post-translational protein modification (Sus scrofa)
Asparagine N-linked glycosylation (Sus scrofa)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Sus scrofa)
Synthesis of substrates in N-glycan biosythesis (Sus scrofa)
Synthesis of UDP-N-acetyl-glucosamine (Sus scrofa)
GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Sus scrofa)
L-Glu [cytosol]
Carboxyterminal post-translational modifications of tubulin (Sus scrofa)
TTLLs polyglutamylate tubulin (Sus scrofa)
L-Glu [cytosol]
Neuronal System (Sus scrofa)
Transmission across Chemical Synapses (Sus scrofa)
Neurotransmitter release cycle (Sus scrofa)
GABA synthesis, release, reuptake and degradation (Sus scrofa)
GABA synthesis (Sus scrofa)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Sus scrofa)
L-Glu [cytosol]
Synthesis of GABA by GAD2 (Sus scrofa)
L-Glu [cytosol]
Glutamate Neurotransmitter Release Cycle (Sus scrofa)
L-Glutamate loading of synaptic vesicle (Sus scrofa)
L-Glu [cytosol]
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Sus scrofa)
L-Glu [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Sus scrofa)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Sus scrofa)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Sus scrofa)
L-Glu [cytosol]
glutamate uptake by astrocytes (Sus scrofa)
L-Glu [cytosol]
Transport of small molecules (Sus scrofa)
SLC-mediated transmembrane transport (Sus scrofa)
Transport of inorganic cations/anions and amino acids/oligopeptides (Sus scrofa)
Amino acid transport across the plasma membrane (Sus scrofa)
SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Sus scrofa)
L-Glu [cytosol]
Organic anion transporters (Sus scrofa)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Sus scrofa)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Sus scrofa)
L-Glu [cytosol]
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Sus scrofa)
L-Glu,L-Asp,D-Asp [cytosol]
L-Glu [cytosol]
Drug ADME (Xenopus tropicalis)
Azathioprine ADME (Xenopus tropicalis)
GMPS dimer transforms 6TXMP to 6TGMP (Xenopus tropicalis)
L-Glu [cytosol]
Metabolism (Xenopus tropicalis)
Aerobic respiration and respiratory electron transport (Xenopus tropicalis)
Pyruvate metabolism (Xenopus tropicalis)
PXLP-K314-GPT transaminates L-Ala to form PYR (Xenopus tropicalis)
L-Glu [cytosol]
Respiratory electron transport (Xenopus tropicalis)
Malate-aspartate shuttle (Xenopus tropicalis)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Xenopus tropicalis)
L-Glu [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Xenopus tropicalis)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Xenopus tropicalis)
L-Glu [cytosol]
Biological oxidations (Xenopus tropicalis)
Phase II - Conjugation of compounds (Xenopus tropicalis)
Glutathione conjugation (Xenopus tropicalis)
Glutathione synthesis and recycling (Xenopus tropicalis)
GCL ligates L-Glu to L-Cys (Xenopus tropicalis)
L-Glu [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Xenopus tropicalis)
L-Glu [cytosol]
Metabolism of amino acids and derivatives (Xenopus tropicalis)
Alanine metabolism (Xenopus tropicalis)
PXLP-K314-GPT transaminates L-Ala to form PYR (Xenopus tropicalis)
L-Glu [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Xenopus tropicalis)
L-Glu [cytosol]
Aspartate and asparagine metabolism (Xenopus tropicalis)
NAALADases hydrolyse NAAG (Xenopus tropicalis)
L-Glu [cytosol]
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Xenopus tropicalis)
L-Glu [cytosol]
SLC25A12,13 exchange L-Glu and L-Asp (Xenopus tropicalis)
L-Glu [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Xenopus tropicalis)
L-Glu [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Xenopus tropicalis)
L-Glu [cytosol]
Branched-chain amino acid catabolism (Xenopus tropicalis)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Xenopus tropicalis)
L-Glu [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Xenopus tropicalis)
L-Glu [cytosol]
Glutamate and glutamine metabolism (Xenopus tropicalis)
N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Xenopus tropicalis)
L-Glu [cytosol]
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Xenopus tropicalis)
L-Glu [cytosol]
Histidine catabolism (Xenopus tropicalis)
N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Xenopus tropicalis)
L-Glu [cytosol]
Phenylalanine and tyrosine metabolism (Xenopus tropicalis)
Tyrosine catabolism (Xenopus tropicalis)
TAT aminates HPP (Xenopus tropicalis)
L-Glu [cytosol]
TAT deaminates tyrosine (Xenopus tropicalis)
L-Glu [cytosol]
Serine biosynthesis (Xenopus tropicalis)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Xenopus tropicalis)
L-Glu [cytosol]
Metabolism of nucleotides (Xenopus tropicalis)
Nucleotide biosynthesis (Xenopus tropicalis)
Purine ribonucleoside monophosphate biosynthesis (Xenopus tropicalis)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Xenopus tropicalis)
L-Glu [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Xenopus tropicalis)
L-Glu [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Xenopus tropicalis)
L-Glu [cytosol]
Pyrimidine biosynthesis (Xenopus tropicalis)
CAD hexamer transforms L-Gln to CAP (Xenopus tropicalis)
L-Glu [cytosol]
Metabolism of vitamins and cofactors (Xenopus tropicalis)
Metabolism of water-soluble vitamins and cofactors (Xenopus tropicalis)
Metabolism of folate and pterines (Xenopus tropicalis)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Xenopus tropicalis)
L-Glu [cytosol]
FPGS-2 transforms THF to THFPG (Xenopus tropicalis)
L-Glu [cytosol]
Metabolism of proteins (Xenopus tropicalis)
Post-translational protein modification (Xenopus tropicalis)
Asparagine N-linked glycosylation (Xenopus tropicalis)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Xenopus tropicalis)
Synthesis of substrates in N-glycan biosythesis (Xenopus tropicalis)
Synthesis of UDP-N-acetyl-glucosamine (Xenopus tropicalis)
GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Xenopus tropicalis)
L-Glu [cytosol]
Carboxyterminal post-translational modifications of tubulin (Xenopus tropicalis)
TTLLs polyglutamylate tubulin (Xenopus tropicalis)
L-Glu [cytosol]
Neuronal System (Xenopus tropicalis)
Transmission across Chemical Synapses (Xenopus tropicalis)
Neurotransmitter release cycle (Xenopus tropicalis)
GABA synthesis, release, reuptake and degradation (Xenopus tropicalis)
GABA synthesis (Xenopus tropicalis)
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Xenopus tropicalis)
L-Glu [cytosol]
Synthesis of GABA by GAD2 (Xenopus tropicalis)
L-Glu [cytosol]
Glutamate Neurotransmitter Release Cycle (Xenopus tropicalis)
L-Glutamate loading of synaptic vesicle (Xenopus tropicalis)
L-Glu [cytosol]
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Xenopus tropicalis)
L-Glu [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Xenopus tropicalis)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Xenopus tropicalis)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Xenopus tropicalis)
L-Glu [cytosol]
glutamate uptake by astrocytes (Xenopus tropicalis)
L-Glu [cytosol]
Transport of small molecules (Xenopus tropicalis)
SLC-mediated transmembrane transport (Xenopus tropicalis)
Transport of inorganic cations/anions and amino acids/oligopeptides (Xenopus tropicalis)
Amino acid transport across the plasma membrane (Xenopus tropicalis)
SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Xenopus tropicalis)
L-Glu [cytosol]
Organic anion transporters (Xenopus tropicalis)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Xenopus tropicalis)
L-Glu [cytosol]
SLC25A18,22 import L-Glu, H+ (Xenopus tropicalis)
L-Glu [cytosol]
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Xenopus tropicalis)
L-Glu,L-Asp,D-Asp [cytosol]
L-Glu [cytosol]
External Reference Information
External Reference
L-glutamate(1-) [ChEBI:29985]
Participates
as an input of
aspartate [mitochondrial matrix] + glutamate [cytosol] <=> aspartate [cytosol] + glutamate [mitochondrial matrix] (Gallus gallus)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate) (Gallus gallus)
glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)
TTLLs polyglutamylate tubulin (Plasmodium falciparum)
TTLLs polyglutamylate tubulin (Xenopus tropicalis)
TTLLs polyglutamylate tubulin (Sus scrofa)
TTLLs polyglutamylate tubulin (Bos taurus)
TTLLs polyglutamylate tubulin (Canis familiaris)
TTLLs polyglutamylate tubulin (Rattus norvegicus)
TTLLs polyglutamylate tubulin (Mus musculus)
TTLLs polyglutamylate tubulin (Homo sapiens)
Polyglutamylase complex (Ttll1) polyglutamylates alpha subunits of tubulin (Homo sapiens)
Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)
Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+ (Homo sapiens)
Defective GCLC does not ligate L-Glu to L-Cys (Homo sapiens)
GCL ligates L-Glu to L-Cys (Schizosaccharomyces pombe)
GCL ligates L-Glu to L-Cys (Caenorhabditis elegans)
GCL ligates L-Glu to L-Cys (Drosophila melanogaster)
GCL ligates L-Glu to L-Cys (Xenopus tropicalis)
GCL ligates L-Glu to L-Cys (Sus scrofa)
GCL ligates L-Glu to L-Cys (Bos taurus)
GCL ligates L-Glu to L-Cys (Canis familiaris)
GCL ligates L-Glu to L-Cys (Rattus norvegicus)
GCL ligates L-Glu to L-Cys (Homo sapiens)
GCL ligates L-Glu to L-Cys (Mus musculus)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Saccharomyces cerevisiae)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Schizosaccharomyces pombe)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Dictyostelium discoideum)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Caenorhabditis elegans)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Drosophila melanogaster)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Gallus gallus)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Xenop
![L-Glu [cytosol] icon](/icon/R-ICO-012775.svg){kind=icon}