Reactome | H2O2 [cytosol]

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Cellular responses to external stimuli (Bos taurus)

- Cellular responses to stress (Bos taurus)
  - Detoxification of Reactive Oxygen Species (Bos taurus)

Gene expression (Transcription) (Bos taurus)

- RNA Polymerase II Transcription (Bos taurus)
  - Generic Transcription Pathway (Bos taurus)
    - Transcriptional Regulation by TP53 (Bos taurus)
      - TP53 Regulates Metabolic Genes (Bos taurus)
        
        GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Bos taurus)
        
        H2O2 [cytosol]
        
        PRDX1 overoxidizes (Bos taurus)
        
        H2O2 [cytosol]
        
        PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Bos taurus)
        
        H2O2 [cytosol]

Hemostasis (Bos taurus)

- Factors involved in megakaryocyte development and platelet production (Bos taurus)
  - MICAL1 produces NADP+, H2O2 (Bos taurus)
    - H2O2 [cytosol]

Metabolism (Bos taurus)

- Biological oxidations (Bos taurus)
  - Phase I - Functionalization of compounds (Bos taurus)
    - Amine Oxidase reactions (Bos taurus)
      - Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Bos taurus)
        
        MAOA:FAD oxidatively deaminates of 5HT (Bos taurus)
        
        H2O2 [cytosol]
- Metabolism of vitamins and cofactors (Bos taurus)
  - Metabolism of water-soluble vitamins and cofactors (Bos taurus)
    - Vitamins B6 activation to pyridoxal phosphate (Bos taurus)
      - 2xPNPO:2xFMN oxidizes PDXP to PXLP (Bos taurus)
        
        H2O2 [cytosol]
      - 2xPNPO:2xFMN oxidizes PXAP to PXLP (Bos taurus)
        
        H2O2 [cytosol]

Neuronal System (Bos taurus)

- Transmission across Chemical Synapses (Bos taurus)
  - Neurotransmitter clearance (Bos taurus)
    - Dopamine clearance from the synaptic cleft (Bos taurus)
      - Enzymatic degradation of dopamine by COMT (Bos taurus)
        
        Oxidation of 3-Methoxytyramine to homovanillic acid (Bos taurus)
        
        H2O2 [cytosol]
    - Serotonin clearance from the synaptic cleft (Bos taurus)
      - Metabolism of serotonin (Bos taurus)
        
        MAOA:FAD oxidatively deaminates of 5HT (Bos taurus)
        
        H2O2 [cytosol]
  - Neurotransmitter release cycle (Bos taurus)
    - Norepinephrine Neurotransmitter Release Cycle (Bos taurus)
      - Metabolism of Noradrenaline (Bos taurus)
        
        H2O2 [cytosol]

Cellular responses to external stimuli (Caenorhabditis elegans)

- Cellular responses to stress (Caenorhabditis elegans)
  - Detoxification of Reactive Oxygen Species (Caenorhabditis elegans)

Gene expression (Transcription) (Caenorhabditis elegans)

- RNA Polymerase II Transcription (Caenorhabditis elegans)
  - Generic Transcription Pathway (Caenorhabditis elegans)
    - Transcriptional Regulation by TP53 (Caenorhabditis elegans)
      - TP53 Regulates Metabolic Genes (Caenorhabditis elegans)
        
        GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)
        
        H2O2 [cytosol]
        
        PRDX1 overoxidizes (Caenorhabditis elegans)
        
        H2O2 [cytosol]
        
        PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Caenorhabditis elegans)
        
        H2O2 [cytosol]

Metabolism (Caenorhabditis elegans)

- Metabolism of nucleotides (Caenorhabditis elegans)
  - Nucleobase catabolism (Caenorhabditis elegans)
    - Purine catabolism (Caenorhabditis elegans)
- Metabolism of vitamins and cofactors (Caenorhabditis elegans)
  - Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
    - Vitamins B6 activation to pyridoxal phosphate (Caenorhabditis elegans)

Cellular responses to external stimuli (Canis familiaris)

- Cellular responses to stress (Canis familiaris)
  - Detoxification of Reactive Oxygen Species (Canis familiaris)

Gene expression (Transcription) (Canis familiaris)

- RNA Polymerase II Transcription (Canis familiaris)
  - Generic Transcription Pathway (Canis familiaris)
    - Transcriptional Regulation by TP53 (Canis familiaris)
      - TP53 Regulates Metabolic Genes (Canis familiaris)
        
        GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)
        
        H2O2 [cytosol]
        
        PRDX1 overoxidizes (Canis familiaris)
        
        H2O2 [cytosol]
        
        PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Canis familiaris)
        
        H2O2 [cytosol]

Hemostasis (Canis familiaris)

- Factors involved in megakaryocyte development and platelet production (Canis familiaris)
  - MICAL1 produces NADP+, H2O2 (Canis familiaris)
    - H2O2 [cytosol]

Metabolism (Canis familiaris)

- Biological oxidations (Canis familiaris)
  - Phase I - Functionalization of compounds (Canis familiaris)
    - Amine Oxidase reactions (Canis familiaris)
      - Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Canis familiaris)
        
        MAOA:FAD oxidatively deaminates of 5HT (Canis familiaris)
        
        H2O2 [cytosol]
- Metabolism of nucleotides (Canis familiaris)
  - Nucleobase catabolism (Canis familiaris)
    - Purine catabolism (Canis familiaris)
- Metabolism of vitamins and cofactors (Canis familiaris)
  - Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
    - Vitamins B6 activation to pyridoxal phosphate (Canis familiaris)

Neuronal System (Canis familiaris)

- Transmission across Chemical Synapses (Canis familiaris)
  - Neurotransmitter clearance (Canis familiaris)
    - Dopamine clearance from the synaptic cleft (Canis familiaris)
      - Enzymatic degradation of dopamine by COMT (Canis familiaris)
        
        Oxidation of 3-Methoxytyramine to homovanillic acid (Canis familiaris)
        
        H2O2 [cytosol]
    - Serotonin clearance from the synaptic cleft (Canis familiaris)
      - Metabolism of serotonin (Canis familiaris)
        
        MAOA:FAD oxidatively deaminates of 5HT (Canis familiaris)
        
        H2O2 [cytosol]
  - Neurotransmitter release cycle (Canis familiaris)
    - Norepinephrine Neurotransmitter Release Cycle (Canis familiaris)
      - Metabolism of Noradrenaline (Canis familiaris)
        
        H2O2 [cytosol]

Cellular responses to external stimuli (Danio rerio)

- Cellular responses to stress (Danio rerio)
  - Detoxification of Reactive Oxygen Species (Danio rerio)

Gene expression (Transcription) (Danio rerio)

- RNA Polymerase II Transcription (Danio rerio)
  - Generic Transcription Pathway (Danio rerio)
    - Transcriptional Regulation by TP53 (Danio rerio)
      - TP53 Regulates Metabolic Genes (Danio rerio)
        
        PRDX1 overoxidizes (Danio rerio)
        
        H2O2 [cytosol]
        
        PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Danio rerio)
        
        H2O2 [cytosol]

Metabolism (Danio rerio)

- Biological oxidations (Danio rerio)
  - Phase I - Functionalization of compounds (Danio rerio)
    - Amine Oxidase reactions (Danio rerio)
      - Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Danio rerio)
        
        MAOA:FAD oxidatively deaminates of 5HT (Danio rerio)
        
        H2O2 [cytosol]
        
        MAOB:FAD oxidatively deaminates TYR (Danio rerio)
        
        H2O2 [cytosol]
        
        MAOB:FAD oxidatively deaminates of PEA (Danio rerio)
        
        H2O2 [cytosol]
- Metabolism of nucleotides (Danio rerio)
  - Nucleobase catabolism (Danio rerio)
    - Purine catabolism (Danio rerio)
- Metabolism of vitamins and cofactors (Danio rerio)
  - Metabolism of water-soluble vitamins and cofactors (Danio rerio)
    - Vitamins B6 activation to pyridoxal phosphate (Danio rerio)

Neuronal System (Danio rerio)

- Transmission across Chemical Synapses (Danio rerio)
  - Neurotransmitter clearance (Danio rerio)
    - Dopamine clearance from the synaptic cleft (Danio rerio)
      - Enzymatic degradation of dopamine by COMT (Danio rerio)
        
        Oxidation of 3-Methoxytyramine to homovanillic acid (Danio rerio)
        
        H2O2 [cytosol]
    - Serotonin clearance from the synaptic cleft (Danio rerio)
      - Metabolism of serotonin (Danio rerio)
        
        MAOA:FAD oxidatively deaminates of 5HT (Danio rerio)
        
        H2O2 [cytosol]
  - Neurotransmitter release cycle (Danio rerio)
    - Norepinephrine Neurotransmitter Release Cycle (Danio rerio)
      - Metabolism of Noradrenaline (Danio rerio)
        
        H2O2 [cytosol]

Cellular responses to external stimuli (Dictyostelium discoideum)

- Cellular responses to stress (Dictyostelium discoideum)
  - Detoxification of Reactive Oxygen Species (Dictyostelium discoideum)

Gene expression (Transcription) (Dictyostelium discoideum)

- RNA Polymerase II Transcription (Dictyostelium discoideum)
  - Generic Transcription Pathway (Dictyostelium discoideum)
    - Transcriptional Regulation by TP53 (Dictyostelium discoideum)
      - TP53 Regulates Metabolic Genes (Dictyostelium discoideum)
        
        PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Dictyostelium discoideum)
        
        H2O2 [cytosol]

Hemostasis (Dictyostelium discoideum)

- Factors involved in megakaryocyte development and platelet production (Dictyostelium discoideum)
  - MICAL1 produces NADP+, H2O2 (Dictyostelium discoideum)
    - H2O2 [cytosol]

Metabolism (Dictyostelium discoideum)

- Biological oxidations (Dictyostelium discoideum)
  - Phase I - Functionalization of compounds (Dictyostelium discoideum)
    - Amine Oxidase reactions (Dictyostelium discoideum)
      - Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Dictyostelium discoideum)
        
        MAOA:FAD oxidatively deaminates of 5HT (Dictyostelium discoideum)
        
        H2O2 [cytosol]
        
        MAOB:FAD oxidatively deaminates TYR (Dictyostelium discoideum)
        
        H2O2 [cytosol]
        
        MAOB:FAD oxidatively deaminates of PEA (Dictyostelium discoideum)
        
        H2O2 [cytosol]
- Metabolism of nucleotides (Dictyostelium discoideum)
  - Nucleobase catabolism (Dictyostelium discoideum)
    - Purine catabolism (Dictyostelium discoideum)
      - Hypoxanthine + H2O + O2 => Xanthine + H2O2 (Dictyostelium discoideum)
        
        H2O2 [cytosol]
      - Xanthine + H2O + O2 => Urate + H2O2 (Dictyostelium discoideum)
        
        H2O2 [cytosol]
- Metabolism of vitamins and cofactors (Dictyostelium discoideum)
  - Metabolism of water-soluble vitamins and cofactors (Dictyostelium discoideum)
    - Vitamins B6 activation to pyridoxal phosphate (Dictyostelium discoideum)

Neuronal System (Dictyostelium discoideum)

- Transmission across Chemical Synapses (Dictyostelium discoideum)
  - Neurotransmitter clearance (Dictyostelium discoideum)
    - Dopamine clearance from the synaptic cleft (Dictyostelium discoideum)
      - Enzymatic degradation of dopamine by COMT (Dictyostelium discoideum)
        
        Oxidation of 3-Methoxytyramine to homovanillic acid (Dictyostelium discoideum)
        
        H2O2 [cytosol]
    - Serotonin clearance from the synaptic cleft (Dictyostelium discoideum)
      - Metabolism of serotonin (Dictyostelium discoideum)
        
        MAOA:FAD oxidatively deaminates of 5HT (Dictyostelium discoideum)
        
        H2O2 [cytosol]
  - Neurotransmitter release cycle (Dictyostelium discoideum)
    - Norepinephrine Neurotransmitter Release Cycle (Dictyostelium discoideum)
      - Metabolism of Noradrenaline (Dictyostelium discoideum)
        
        H2O2 [cytosol]

Cellular responses to external stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - Detoxification of Reactive Oxygen Species (Drosophila melanogaster)
    - PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Drosophila melanogaster)
      - H2O2 [cytosol]
    - SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Drosophila melanogaster)
      - H2O2 [cytosol]

Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - Generic Transcription Pathway (Drosophila melanogaster)
    - Transcriptional Regulation by TP53 (Drosophila melanogaster)
      - TP53 Regulates Metabolic Genes (Drosophila melanogaster)
        
        PRDX1 overoxidizes (Drosophila melanogaster)
        
        H2O2 [cytosol]
        
        PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Drosophila melanogaster)
        
        H2O2 [cytosol]

Metabolism (Drosophila melanogaster)

- Metabolism of nucleotides (Drosophila melanogaster)
  - Nucleobase catabolism (Drosophila melanogaster)
    - Purine catabolism (Drosophila melanogaster)
      - Hypoxanthine + H2O + O2 => Xanthine + H2O2 (Drosophila melanogaster)
        
        H2O2 [cytosol]
      - Xanthine + H2O + O2 => Urate + H2O2 (Drosophila melanogaster)
        
        H2O2 [cytosol]
- Metabolism of vitamins and cofactors (Drosophila melanogaster)
  - Metabolism of water-soluble vitamins and cofactors (Drosophila melanogaster)
    - Vitamins B6 activation to pyridoxal phosphate (Drosophila melanogaster)

Cellular responses to external stimuli (Gallus gallus)

- Cellular responses to stress (Gallus gallus)
  - Detoxification of Reactive Oxygen Species (Gallus gallus)

Gene expression (Transcription) (Gallus gallus)

- RNA Polymerase II Transcription (Gallus gallus)
  - Generic Transcription Pathway (Gallus gallus)
    - Transcriptional Regulation by TP53 (Gallus gallus)
      - TP53 Regulates Metabolic Genes (Gallus gallus)
        
        GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Gallus gallus)
        
        H2O2 [cytosol]
        
        PRDX1 overoxidizes (Gallus gallus)
        
        H2O2 [cytosol]
        
        PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Gallus gallus)
        
        H2O2 [cytosol]

Metabolism (Gallus gallus)

- Biological oxidations (Gallus gallus)
  - Phase I - Functionalization of compounds (Gallus gallus)
    - Amine Oxidase reactions (Gallus gallus)
      - Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Gallus gallus)
        
        MAOA:FAD oxidatively deaminates of 5HT (Gallus gallus)
        
        H2O2 [cytosol]
        
        MAOB:FAD oxidatively deaminates TYR (Gallus gallus)
        
        H2O2 [cytosol]
        
        MAOB:FAD oxidatively deaminates of PEA (Gallus gallus)
        
        H2O2 [cytosol]
- Metabolism of nucleotides (Gallus gallus)
  - Nucleobase catabolism (Gallus gallus)
    - Purine catabolism (Gallus gallus)
- Metabolism of vitamins and cofactors (Gallus gallus)
  - Metabolism of water-soluble vitamins and cofactors (Gallus gallus)
    - Vitamins B6 activation to pyridoxal phosphate (Gallus gallus)

Neuronal System (Gallus gallus)

- Transmission across Chemical Synapses (Gallus gallus)
  - Neurotransmitter clearance (Gallus gallus)
    - Dopamine clearance from the synaptic cleft (Gallus gallus)
      - Enzymatic degradation of dopamine by COMT (Gallus gallus)
        
        Oxidation of 3-Methoxytyramine to homovanillic acid (Gallus gallus)
        
        H2O2 [cytosol]
    - Serotonin clearance from the synaptic cleft (Gallus gallus)
      - Metabolism of serotonin (Gallus gallus)
        
        MAOA:FAD oxidatively deaminates of 5HT (Gallus gallus)
        
        H2O2 [cytosol]
  - Neurotransmitter release cycle (Gallus gallus)
    - Norepinephrine Neurotransmitter Release Cycle (Gallus gallus)
      - Metabolism of Noradrenaline (Gallus gallus)
        
        H2O2 [cytosol]

Cellular responses to external stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Detoxification of Reactive Oxygen Species (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Infection with Mycobacterium tuberculosis (Homo sapiens)
    - Latent infection - Other responses of Mtb to phagocytosis (Homo sapiens)
      - Tolerance of reactive oxygen produced by macrophages (Homo sapiens)
        
        AhpC reduces H2O2 (Homo sapiens)
        
        H2O2 [cytosol]
        
        H2O2 gets scavenged by unsaturated lipid (Homo sapiens)
        
        H2O2 [cytosol]
        
        KatG reduces H2O2 (Homo sapiens)
        
        H2O2 [cytosol]
        
        SodB reduces superoxide to H2O2 (Homo sapiens)
        
        H2O2 [cytosol]
        
        SodC reduces superoxide to H2O2 (Homo sapiens)
        
        H2O2 [cytosol]

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Metabolic Genes (Homo sapiens)
        
        GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)
        
        H2O2 [cytosol]
        
        PRDX1 overoxidizes (Homo sapiens)
        
        H2O2 [cytosol]
        
        PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Homo sapiens)
        
        H2O2 [cytosol]

Hemostasis (Homo sapiens)

- Factors involved in megakaryocyte development and platelet production (Homo sapiens)
  - MICAL1 produces NADP+, H2O2 (Homo sapiens)
    - H2O2 [cytosol]

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - ROS and RNS production in phagocytes (Homo sapiens)
    - Hydrogen peroxide and Fe2+ react to hydroxyl, hydroxide and Fe3+ (Homo sapiens)
      - H2O2 [cytosol]
    - Hydrogen peroxide enters the bacterium (Homo sapiens)
      - H2O2 [cytosol]

Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase I - Functionalization of compounds (Homo sapiens)
    - Amine Oxidase reactions (Homo sapiens)
      - Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Homo sapiens)
        
        MAOA:FAD oxidatively deaminates of 5HT (Homo sapiens)
        
        H2O2 [cytosol]
        
        MAOB:FAD oxidatively deaminates TYR (Homo sapiens)
        
        H2O2 [cytosol]
        
        MAOB:FAD oxidatively deaminates of PEA (Homo sapiens)
        
        H2O2 [cytosol]
- Metabolism of nucleotides (Homo sapiens)
  - Nucleobase catabolism (Homo sapiens)
    - Purine catabolism (Homo sapiens)
- Metabolism of vitamins and cofactors (Homo sapiens)
  - Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
    - Vitamin C (ascorbate) metabolism (Homo sapiens)
      - DeHA hydrolyses to threonate and oxalate (Homo sapiens)
        
        H2O2 [cytosol]
    - Vitamins B6 activation to pyridoxal phosphate (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Protein repair (Homo sapiens)
  - Methionine is oxidised to methionine sulfoxide (Homo sapiens)
    - H2O2 [cytosol]
  - Methionine sulfoxide is oxidised to methionine sulfone (Homo sapiens)
    - H2O2 [cytosol]

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter clearance (Homo sapiens)
    - Dopamine clearance from the synaptic cleft (Homo sapiens)
      - Enzymatic degradation of dopamine by COMT (Homo sapiens)
        
        Oxidation of 3-Methoxytyramine to homovanillic acid (Homo sapiens)
        
        H2O2 [cytosol]
    - Serotonin clearance from the synaptic cleft (Homo sapiens)
      - Metabolism of serotonin (Homo sapiens)
        
        MAOA:FAD oxidatively deaminates of 5HT (Homo sapiens)
        
        H2O2 [cytosol]
  - Neurotransmitter release cycle (Homo sapiens)
    - Norepinephrine Neurotransmitter Release Cycle (Homo sapiens)
      - Metabolism of Noradrenaline (Homo sapiens)
        
        H2O2 [cytosol]

Cellular responses to external stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Detoxification of Reactive Oxygen Species (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional Regulation by TP53 (Mus musculus)
      - TP53 Regulates Metabolic Genes (Mus musculus)
        
        GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)
        
        H2O2 [cytosol]
        
        PRDX1 overoxidizes (Mus musculus)
        
        H2O2 [cytosol]
        
        PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Mus musculus)
        
        H2O2 [cytosol]

Metabolism (Mus musculus)

- Biological oxidations (Mus musculus)
  - Phase I - Functionalization of compounds (Mus musculus)
    - Amine Oxidase reactions (Mus musculus)
      - Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Mus musculus)
        
        MAOA:FAD oxidatively deaminates of 5HT (Mus musculus)
        
        H2O2 [cytosol]
        
        MAOB:FAD oxidatively deaminates TYR (Mus musculus)
        
        H2O2 [cytosol]
        
        MAOB:FAD oxidatively deaminates of PEA (Mus musculus)
        
        H2O2 [cytosol]
- Metabolism of nucleotides (Mus musculus)
  - Nucleobase catabolism (Mus musculus)
    - Purine catabolism (Mus musculus)
- Metabolism of vitamins and cofactors (Mus musculus)
  - Metabolism of water-soluble vitamins and cofactors (Mus musculus)
    - Vitamins B6 activation to pyridoxal phosphate (Mus musculus)

Neuronal System (Mus musculus)

- Transmission across Chemical Synapses (Mus musculus)
  - Neurotransmitter clearance (Mus musculus)
    - Dopamine clearance from the synaptic cleft (Mus musculus)
      - Enzymatic degradation of dopamine by COMT (Mus musculus)
        
        Oxidation of 3-Methoxytyramine to homovanillic acid (Mus musculus)
        
        H2O2 [cytosol]
    - Serotonin clearance from the synaptic cleft (Mus musculus)
      - Metabolism of serotonin (Mus musculus)
        
        MAOA:FAD oxidatively deaminates of 5HT (Mus musculus)
        
        H2O2 [cytosol]
  - Neurotransmitter release cycle (Mus musculus)
    - Norepinephrine Neurotransmitter Release Cycle (Mus musculus)
      - Metabolism of Noradrenaline (Mus musculus)
        
        H2O2 [cytosol]

Cellular responses to external stimuli (Plasmodium falciparum)

- Cellular responses to stress (Plasmodium falciparum)
  - Detoxification of Reactive Oxygen Species (Plasmodium falciparum)
    - PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Plasmodium falciparum)
      - H2O2 [cytosol]
    - PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Plasmodium falciparum)
      - H2O2 [cytosol]

Gene expression (Transcription) (Plasmodium falciparum)

- RNA Polymerase II Transcription (Plasmodium falciparum)
  - Generic Transcription Pathway (Plasmodium falciparum)
    - Transcriptional Regulation by TP53 (Plasmodium falciparum)
      - TP53 Regulates Metabolic Genes (Plasmodium falciparum)
        
        PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Plasmodium falciparum)
        
        H2O2 [cytosol]

Cellular responses to external stimuli (Rattus norvegicus)

- Cellular responses to stress (Rattus norvegicus)
  - Detoxification of Reactive Oxygen Species (Rattus norvegicus)

Gene expression (Transcription) (Rattus norvegicus)

- RNA Polymerase II Transcription (Rattus norvegicus)
  - Generic Transcription Pathway (Rattus norvegicus)
    - Transcriptional Regulation by TP53 (Rattus norvegicus)
      - TP53 Regulates Metabolic Genes (Rattus norvegicus)
        
        GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)
        
        H2O2 [cytosol]
        
        PRDX1 overoxidizes (Rattus norvegicus)
        
        H2O2 [cytosol]
        
        PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Rattus norvegicus)
        
        H2O2 [cytosol]

Metabolism (Rattus norvegicus)

- Biological oxidations (Rattus norvegicus)
  - Phase I - Functionalization of compounds (Rattus norvegicus)
    - Amine Oxidase reactions (Rattus norvegicus)
      - Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Rattus norvegicus)
        
        MAOA:FAD oxidatively deaminates of 5HT (Rattus norvegicus)
        
        H2O2 [cytosol]
        
        MAOB:FAD oxidatively deaminates TYR (Rattus norvegicus)
        
        H2O2 [cytosol]
        
        MAOB:FAD oxidatively deaminates of PEA (Rattus norvegicus)
        
        H2O2 [cytosol]
- Metabolism of nucleotides (Rattus norvegicus)
  - Nucleobase catabolism (Rattus norvegicus)
    - Purine catabolism (Rattus norvegicus)
- Metabolism of vitamins and cofactors (Rattus norvegicus)
  - Metabolism of water-soluble vitamins and cofactors (Rattus norvegicus)
    - Vitamins B6 activation to pyridoxal phosphate (Rattus norvegicus)

Neuronal System (Rattus norvegicus)

- Transmission across Chemical Synapses (Rattus norvegicus)
  - Neurotransmitter clearance (Rattus norvegicus)
    - Dopamine clearance from the synaptic cleft (Rattus norvegicus)
      - Enzymatic degradation of dopamine by COMT (Rattus norvegicus)
        
        Oxidation of 3-Methoxytyramine to homovanillic acid (Rattus norvegicus)
        
        H2O2 [cytosol]
    - Serotonin clearance from the synaptic cleft (Rattus norvegicus)
      - Metabolism of serotonin (Rattus norvegicus)
        
        MAOA:FAD oxidatively deaminates of 5HT (Rattus norvegicus)
        
        H2O2 [cytosol]
  - Neurotransmitter release cycle (Rattus norvegicus)
    - Norepinephrine Neurotransmitter Release Cycle (Rattus norvegicus)
      - Metabolism of Noradrenaline (Rattus norvegicus)
        
        H2O2 [cytosol]

Cellular responses to external stimuli (Saccharomyces cerevisiae)

- Cellular responses to stress (Saccharomyces cerevisiae)
  - Detoxification of Reactive Oxygen Species (Saccharomyces cerevisiae)
    - SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Saccharomyces cerevisiae)
      - H2O2 [cytosol]

Metabolism (Saccharomyces cerevisiae)

- Metabolism of vitamins and cofactors (Saccharomyces cerevisiae)
  - Metabolism of water-soluble vitamins and cofactors (Saccharomyces cerevisiae)
    - Vitamins B6 activation to pyridoxal phosphate (Saccharomyces cerevisiae)
      - 2xPNPO:2xFMN oxidizes PDXP to PXLP (Saccharomyces cerevisiae)
        
        H2O2 [cytosol]
      - 2xPNPO:2xFMN oxidizes PXAP to PXLP (Saccharomyces cerevisiae)
        
        H2O2 [cytosol]

Cellular responses to external stimuli (Schizosaccharomyces pombe)

- Cellular responses to stress (Schizosaccharomyces pombe)
  - Detoxification of Reactive Oxygen Species (Schizosaccharomyces pombe)
    - PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Schizosaccharomyces pombe)
      - H2O2 [cytosol]
    - SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Schizosaccharomyces pombe)
      - H2O2 [cytosol]

Gene expression (Transcription) (Schizosaccharomyces pombe)

- RNA Polymerase II Transcription (Schizosaccharomyces pombe)
  - Generic Transcription Pathway (Schizosaccharomyces pombe)
    - Transcriptional Regulation by TP53 (Schizosaccharomyces pombe)
      - TP53 Regulates Metabolic Genes (Schizosaccharomyces pombe)
        
        PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Schizosaccharomyces pombe)
        
        H2O2 [cytosol]

Metabolism (Schizosaccharomyces pombe)

- Metabolism of vitamins and cofactors (Schizosaccharomyces pombe)
  - Metabolism of water-soluble vitamins and cofactors (Schizosaccharomyces pombe)
    - Vitamins B6 activation to pyridoxal phosphate (Schizosaccharomyces pombe)
      - 2xPNPO:2xFMN oxidizes PDXP to PXLP (Schizosaccharomyces pombe)
        
        H2O2 [cytosol]
      - 2xPNPO:2xFMN oxidizes PXAP to PXLP (Schizosaccharomyces pombe)
        
        H2O2 [cytosol]

Cellular responses to external stimuli (Sus scrofa)

- Cellular responses to stress (Sus scrofa)
  - Detoxification of Reactive Oxygen Species (Sus scrofa)

Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase II Transcription (Sus scrofa)
  - Generic Transcription Pathway (Sus scrofa)
    - Transcriptional Regulation by TP53 (Sus scrofa)
      - TP53 Regulates Metabolic Genes (Sus scrofa)
        
        GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)
        
        H2O2 [cytosol]
        
        PRDX1 overoxidizes (Sus scrofa)
        
        H2O2 [cytosol]
        
        PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Sus scrofa)
        
        H2O2 [cytosol]

Hemostasis (Sus scrofa)

- Factors involved in megakaryocyte development and platelet production (Sus scrofa)
  - MICAL1 produces NADP+, H2O2 (Sus scrofa)
    - H2O2 [cytosol]

Metabolism (Sus scrofa)

- Biological oxidations (Sus scrofa)
  - Phase I - Functionalization of compounds (Sus scrofa)
    - Amine Oxidase reactions (Sus scrofa)
      - Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Sus scrofa)
        
        MAOB:FAD oxidatively deaminates TYR (Sus scrofa)
        
        H2O2 [cytosol]
        
        MAOB:FAD oxidatively deaminates of PEA (Sus scrofa)
        
        H2O2 [cytosol]
- Metabolism of nucleotides (Sus scrofa)
  - Nucleobase catabolism (Sus scrofa)
    - Purine catabolism (Sus scrofa)
- Metabolism of vitamins and cofactors (Sus scrofa)
  - Metabolism of water-soluble vitamins and cofactors (Sus scrofa)
    - Vitamins B6 activation to pyridoxal phosphate (Sus scrofa)

Cellular responses to external stimuli (Xenopus tropicalis)

- Cellular responses to stress (Xenopus tropicalis)
  - Detoxification of Reactive Oxygen Species (Xenopus tropicalis)

Gene expression (Transcription) (Xenopus tropicalis)

- RNA Polymerase II Transcription (Xenopus tropicalis)
  - Generic Transcription Pathway (Xenopus tropicalis)
    - Transcriptional Regulation by TP53 (Xenopus tropicalis)
      - TP53 Regulates Metabolic Genes (Xenopus tropicalis)
        
        GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Xenopus tropicalis)
        
        H2O2 [cytosol]
        
        PRDX1 overoxidizes (Xenopus tropicalis)
        
        H2O2 [cytosol]
        
        PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Xenopus tropicalis)
        
        H2O2 [cytosol]

Metabolism (Xenopus tropicalis)

- Biological oxidations (Xenopus tropicalis)
  - Phase I - Functionalization of compounds (Xenopus tropicalis)
    - Amine Oxidase reactions (Xenopus tropicalis)
      - Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Xenopus tropicalis)
        
        MAOA:FAD oxidatively deaminates of 5HT (Xenopus tropicalis)
        
        H2O2 [cytosol]
        
        MAOB:FAD oxidatively deaminates TYR (Xenopus tropicalis)
        
        H2O2 [cytosol]
        
        MAOB:FAD oxidatively deaminates of PEA (Xenopus tropicalis)
        
        H2O2 [cytosol]
- Metabolism of nucleotides (Xenopus tropicalis)
  - Nucleobase catabolism (Xenopus tropicalis)
    - Purine catabolism (Xenopus tropicalis)
- Metabolism of vitamins and cofactors (Xenopus tropicalis)
  - Metabolism of water-soluble vitamins and cofactors (Xenopus tropicalis)
    - Vitamins B6 activation to pyridoxal phosphate (Xenopus tropicalis)

Neuronal System (Xenopus tropicalis)

- Transmission across Chemical Synapses (Xenopus tropicalis)
  - Neurotransmitter clearance (Xenopus tropicalis)
    - Dopamine clearance from the synaptic cleft (Xenopus tropicalis)
      - Enzymatic degradation of dopamine by COMT (Xenopus tropicalis)
        
        Oxidation of 3-Methoxytyramine to homovanillic acid (Xenopus tropicalis)
        
        H2O2 [cytosol]
    - Serotonin clearance from the synaptic cleft (Xenopus tropicalis)
      - Metabolism of serotonin (Xenopus tropicalis)
        
        MAOA:FAD oxidatively deaminates of 5HT (Xenopus tropicalis)
        
        H2O2 [cytosol]
  - Neurotransmitter release cycle (Xenopus tropicalis)
    - Norepinephrine Neurotransmitter Release Cycle (Xenopus tropicalis)
      - Metabolism of Noradrenaline (Xenopus tropicalis)
        
        H2O2 [cytosol]