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What is Reactome ?
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
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Analysis Gene Expression
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GDP [cytosol]
Stable Identifier
R-ALL-29420
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
Guanosine 5'-diphosphate, Guanosine diphosphate
Locations in the PathwayBrowser for interactor UniProt:P37840
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Mycobacterium tuberculosis
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cell Cycle (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
M Phase (Bos taurus)
Mitotic Metaphase and Anaphase (Bos taurus)
Mitotic Anaphase (Bos taurus)
Nuclear Envelope (NE) Reassembly (Bos taurus)
Postmitotic nuclear pore complex (NPC) reformation (Bos taurus)
RCC1 stimulates GDP to GTP exchange on RAN (Bos taurus)
GDP [cytosol]
Cellular responses to external stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to starvation (Bos taurus)
Amino acids regulate mTORC1 (Bos taurus)
RRAGA,B exchanges GDP for GTP (Bos taurus)
GDP [cytosol]
RRAGC,D exchanges GTP for GDP (Bos taurus)
GDP [cytosol]
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
EPH-Ephrin signaling (Bos taurus)
EPHA-mediated growth cone collapse (Bos taurus)
NGEF exchanges GTP for GDP on RHOA (Bos taurus)
GDP [cytosol]
EPHB-mediated forward signaling (Bos taurus)
p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Bos taurus)
GDP [cytosol]
NCAM signaling for neurite out-growth (Bos taurus)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Bos taurus)
GDP [cytosol]
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
GPVI-mediated activation cascade (Bos taurus)
VAV2 is a GEF for Rho/Rac family kinases (Bos taurus)
GDP [cytosol]
Platelet Aggregation (Plug Formation) (Bos taurus)
Integrin signaling (Bos taurus)
Activation of Rap1 by cytosolic GEFs (Bos taurus)
GDP [cytosol]
Activation of Rap1 by membrane-associated GEFs (Bos taurus)
GDP [cytosol]
Signal amplification (Bos taurus)
ADP signalling through P2Y purinoceptor 12 (Bos taurus)
Gi activation by P2Y purinoceptor 12 (Bos taurus)
GDP [cytosol]
Thromboxane signalling through TP receptor (Bos taurus)
G13 activation by TP receptor (Bos taurus)
GDP [cytosol]
Gq activation by TP receptor (Bos taurus)
GDP [cytosol]
Thrombin signalling through proteinase activated receptors (PARs) (Bos taurus)
Thrombin-activated PARs activate G12/13 (Bos taurus)
GDP [cytosol]
Thrombin-activated PARs activate Gq (Bos taurus)
GDP [cytosol]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Rap1 signalling (Bos taurus)
Activation of Rap1 by cytosolic GEFs (Bos taurus)
GDP [cytosol]
Activation of Rap1 by membrane-associated GEFs (Bos taurus)
GDP [cytosol]
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Downstream signaling events of B Cell Receptor (BCR) (Bos taurus)
Activation of RAS in B cells (Bos taurus)
p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Bos taurus)
GDP [cytosol]
Cytokine Signaling in Immune system (Bos taurus)
FLT3 Signaling (Bos taurus)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Bos taurus)
GDP [cytosol]
Innate Immune System (Bos taurus)
DAP12 interactions (Bos taurus)
DAP12 signaling (Bos taurus)
SOS mediated nucleotide exchange of RAS (SHC) (Bos taurus)
GDP [cytosol]
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated MAPK activation (Bos taurus)
SOS mediated nucleotide exchange of RAS (SHC) (Bos taurus)
GDP [cytosol]
Metabolism (Bos taurus)
Integration of energy metabolism (Bos taurus)
Regulation of insulin secretion (Bos taurus)
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Bos taurus)
RAP1A exchanges GDP for GTP (Bos taurus)
GDP [cytosol]
Metabolism of nucleotides (Bos taurus)
Nucleobase biosynthesis (Bos taurus)
Purine ribonucleoside monophosphate biosynthesis (Bos taurus)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Bos taurus)
GDP [cytosol]
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Asparagine N-linked glycosylation (Bos taurus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Bos taurus)
Addition of a second mannose to the N-glycan precursor by ALG2 (Bos taurus)
GDP [cytosol]
Addition of the first mannose to the N-glycan precursor by ALG1 (Bos taurus)
GDP [cytosol]
Transport to the Golgi and subsequent modification (Bos taurus)
ER to Golgi Anterograde Transport (Bos taurus)
COPII-mediated vesicle transport (Bos taurus)
Nucleotide exchange on RAB1 (Bos taurus)
GDP [cytosol]
SAR1 Activation And Membrane Binding (Bos taurus)
GDP [cytosol]
Organelle biogenesis and maintenance (Bos taurus)
Cilium Assembly (Bos taurus)
Cargo trafficking to the periciliary membrane (Bos taurus)
VxPx cargo-targeting to cilium (Bos taurus)
GBF1 stimulates nucleotide exchange on ARF4 (Bos taurus)
GDP [cytosol]
Signal Transduction (Bos taurus)
Integrin signaling (Bos taurus)
Activation of Rap1 by cytosolic GEFs (Bos taurus)
GDP [cytosol]
Activation of Rap1 by membrane-associated GEFs (Bos taurus)
GDP [cytosol]
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
Intrinsic nucleotide exchange on RAS (Bos taurus)
GDP [cytosol]
RAS GEFs promote RAS nucleotide exchange (Bos taurus)
GDP [cytosol]
RAS processing (Bos taurus)
mature p21 RAS binds GDP (Bos taurus)
GDP [cytosol]
MTOR signalling (Bos taurus)
GTP loading by Rheb (Bos taurus)
GDP [cytosol]
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (12/13) signalling events (Bos taurus)
GEFs activate RhoA,B,C (Bos taurus)
GDP [cytosol]
Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Bos taurus)
GDP [cytosol]
p115-RhoGEF activation of RHOA (Bos taurus)
GDP [cytosol]
G alpha (i) signalling events (Bos taurus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Bos taurus)
GDP [cytosol]
Opioid Signalling (Bos taurus)
G-protein activation (Bos taurus)
G-protein alpha subunit is inactivated (Bos taurus)
GDP [cytosol]
Opsins act as GEFs for G alpha-t (Bos taurus)
GDP [cytosol]
G alpha (q) signalling events (Bos taurus)
Gastrin-CREB signalling pathway via PKC and MAPK (Bos taurus)
EGFR Transactivation by Gastrin (Bos taurus)
SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Bos taurus)
GDP [cytosol]
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Bos taurus)
GDP [cytosol]
G alpha (z) signalling events (Bos taurus)
Liganded Gz-activating GPCR acts as a GEF for Gz (Bos taurus)
GDP [cytosol]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by EGFR (Bos taurus)
GRB2 events in EGFR signaling (Bos taurus)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Bos taurus)
GDP [cytosol]
SHC1 events in EGFR signaling (Bos taurus)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Bos taurus)
GDP [cytosol]
Signaling by ERBB2 (Bos taurus)
GRB2 events in ERBB2 signaling (Bos taurus)
RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Bos taurus)
GDP [cytosol]
Signaling by ERBB4 (Bos taurus)
SHC1 events in ERBB4 signaling (Bos taurus)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Bos taurus)
GDP [cytosol]
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Downstream signaling of activated FGFR1 (Bos taurus)
FRS-mediated FGFR1 signaling (Bos taurus)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
GDP [cytosol]
Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)
GDP [cytosol]
SHC-mediated cascade:FGFR1 (Bos taurus)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
GDP [cytosol]
Signaling by FGFR2 (Bos taurus)
Downstream signaling of activated FGFR2 (Bos taurus)
FRS-mediated FGFR2 signaling (Bos taurus)
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
GDP [cytosol]
Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)
GDP [cytosol]
SHC-mediated cascade:FGFR2 (Bos taurus)
Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
GDP [cytosol]
Signaling by FGFR3 (Bos taurus)
Downstream signaling of activated FGFR3 (Bos taurus)
FRS-mediated FGFR3 signaling (Bos taurus)
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
GDP [cytosol]
Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)
GDP [cytosol]
SHC-mediated cascade:FGFR3 (Bos taurus)
Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
GDP [cytosol]
Signaling by FGFR4 (Bos taurus)
Downstream signaling of activated FGFR4 (Bos taurus)
FRS-mediated FGFR4 signaling (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
GDP [cytosol]
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)
GDP [cytosol]
SHC-mediated cascade:FGFR4 (Bos taurus)
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
GDP [cytosol]
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
Signalling to ERKs (Bos taurus)
Prolonged ERK activation events (Bos taurus)
ARMS-mediated activation (Bos taurus)
C3G stimulates nucleotide exchange on Rap1 (Bos taurus)
GDP [cytosol]
Signaling by SCF-KIT (Bos taurus)
Activation of RAS by p-KIT bound SOS1 (Bos taurus)
GDP [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase cycle (Bos taurus)
RAC2 GTPase cycle (Bos taurus)
RAC2 GEFs activate RAC2 (Bos taurus)
GDP [cytosol]
RAC3 GTPase cycle (Bos taurus)
RAC3 GEFs activate RAC3 (Bos taurus)
GDP [cytosol]
RHOA GTPase cycle (Bos taurus)
RHOA GEFs activate RHOA (Bos taurus)
GDP [cytosol]
RHOC GTPase cycle (Bos taurus)
RHOC GEFs activate RHOC (Bos taurus)
GDP [cytosol]
RHOD GTPase cycle (Bos taurus)
RHOD auto-activates (Bos taurus)
GDP [cytosol]
RHOF GTPase cycle (Bos taurus)
RHOF auto-activates (Bos taurus)
GDP [cytosol]
RHOG GTPase cycle (Bos taurus)
RHOG GEFs activate RHOG (Bos taurus)
GDP [cytosol]
RHOJ GTPase cycle (Bos taurus)
RHOJ GEFs activate RHOJ (Bos taurus)
GDP [cytosol]
RHOU GTPase cycle (Bos taurus)
RHOU auto-activates (Bos taurus)
GDP [cytosol]
Vesicle-mediated transport (Bos taurus)
Membrane Trafficking (Bos taurus)
ER to Golgi Anterograde Transport (Bos taurus)
COPII-mediated vesicle transport (Bos taurus)
Nucleotide exchange on RAB1 (Bos taurus)
GDP [cytosol]
SAR1 Activation And Membrane Binding (Bos taurus)
GDP [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Bos taurus)
Golgi-to-ER retrograde transport (Bos taurus)
COPI-dependent Golgi-to-ER retrograde traffic (Bos taurus)
GBF1 stimulates nucleotide exchange on ARF (Bos taurus)
GDP [cytosol]
Rab regulation of trafficking (Bos taurus)
RAB GEFs exchange GTP for GDP on RABs (Bos taurus)
DENND3 exchanges GTP for GDP on RAB12 (Bos taurus)
GDP [cytosol]
DENND4s exchange GTP for GDP on RAB10 (Bos taurus)
GDP [cytosol]
DENND5A,B exchange GTP for GDP on RAB39 (Bos taurus)
GDP [cytosol]
DENND6A,B exchange GTP for GDP on RAB14 (Bos taurus)
GDP [cytosol]
HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Bos taurus)
GDP [cytosol]
RAB21 GEFs exchange GTP for GDP on RAB21 (Bos taurus)
GDP [cytosol]
RAB31 GEFs exchange GTP for GDP on RAB31 (Bos taurus)
GDP [cytosol]
TRAPPC complexes exchange GTP for GDP on RAB1 (Bos taurus)
GDP [cytosol]
trans-Golgi Network Vesicle Budding (Bos taurus)
trans-Golgi Network Coat Activation (Bos taurus)
GDP [cytosol]
Cell Cycle (Caenorhabditis elegans)
Cell Cycle, Mitotic (Caenorhabditis elegans)
M Phase (Caenorhabditis elegans)
Mitotic Metaphase and Anaphase (Caenorhabditis elegans)
Mitotic Anaphase (Caenorhabditis elegans)
Nuclear Envelope (NE) Reassembly (Caenorhabditis elegans)
Postmitotic nuclear pore complex (NPC) reformation (Caenorhabditis elegans)
RCC1 stimulates GDP to GTP exchange on RAN (Caenorhabditis elegans)
GDP [cytosol]
Cellular responses to external stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to starvation (Caenorhabditis elegans)
Amino acids regulate mTORC1 (Caenorhabditis elegans)
RRAGA,B exchanges GDP for GTP (Caenorhabditis elegans)
GDP [cytosol]
RRAGC,D exchanges GTP for GDP (Caenorhabditis elegans)
GDP [cytosol]
Developmental Biology (Caenorhabditis elegans)
Nervous system development (Caenorhabditis elegans)
Axon guidance (Caenorhabditis elegans)
EPH-Ephrin signaling (Caenorhabditis elegans)
EPH-ephrin mediated repulsion of cells (Caenorhabditis elegans)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)
GDP [cytosol]
VAV exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)
GDP [cytosol]
EPHA-mediated growth cone collapse (Caenorhabditis elegans)
NGEF exchanges GTP for GDP on RHOA (Caenorhabditis elegans)
GDP [cytosol]
EPHB-mediated forward signaling (Caenorhabditis elegans)
p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)
GDP [cytosol]
p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Caenorhabditis elegans)
GDP [cytosol]
L1CAM interactions (Caenorhabditis elegans)
Recycling pathway of L1 (Caenorhabditis elegans)
Formation of clathrin coated vesicle (Caenorhabditis elegans)
GDP [cytosol]
Signal transduction by L1 (Caenorhabditis elegans)
Activation of Rac1 by VAV2 (Caenorhabditis elegans)
GDP [cytosol]
NCAM signaling for neurite out-growth (Caenorhabditis elegans)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Caenorhabditis elegans)
GDP [cytosol]
Netrin-1 signaling (Caenorhabditis elegans)
DCC mediated attractive signaling (Caenorhabditis elegans)
Activation of Cdc42 (Caenorhabditis elegans)
GDP [cytosol]
Activation of Rac1 (Caenorhabditis elegans)
GDP [cytosol]
Semaphorin interactions (Caenorhabditis elegans)
Sema4D in semaphorin signaling (Caenorhabditis elegans)
Sema4D induced cell migration and growth-cone collapse (Caenorhabditis elegans)
Activation of Rho by LARG and PDZ-RhoGEF (Caenorhabditis elegans)
GDP [cytosol]
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
GPVI-mediated activation cascade (Caenorhabditis elegans)
VAV1 is a GEF for Rho/Rac family GTPases (Caenorhabditis elegans)
GDP [cytosol]
VAV2 is a GEF for Rho/Rac family kinases (Caenorhabditis elegans)
GDP [cytosol]
VAV3 is a GEF for Rho/Rac family kinases (Caenorhabditis elegans)
GDP [cytosol]
Platelet Aggregation (Plug Formation) (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Activation of Rap1 by cytosolic GEFs (Caenorhabditis elegans)
GDP [cytosol]
Activation of Rap1 by membrane-associated GEFs (Caenorhabditis elegans)
GDP [cytosol]
Signal amplification (Caenorhabditis elegans)
ADP signalling through P2Y purinoceptor 12 (Caenorhabditis elegans)
Gi activation by P2Y purinoceptor 12 (Caenorhabditis elegans)
GDP [cytosol]
Thromboxane signalling through TP receptor (Caenorhabditis elegans)
G13 activation by TP receptor (Caenorhabditis elegans)
GDP [cytosol]
Gq activation by TP receptor (Caenorhabditis elegans)
GDP [cytosol]
Thrombin signalling through proteinase activated receptors (PARs) (Caenorhabditis elegans)
Thrombin-activated PARs activate G12/13 (Caenorhabditis elegans)
GDP [cytosol]
Thrombin-activated PARs activate Gq (Caenorhabditis elegans)
GDP [cytosol]
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Rap1 signalling (Caenorhabditis elegans)
Activation of Rap1 by cytosolic GEFs (Caenorhabditis elegans)
GDP [cytosol]
Activation of Rap1 by membrane-associated GEFs (Caenorhabditis elegans)
GDP [cytosol]
Signaling by the B Cell Receptor (BCR) (Caenorhabditis elegans)
Downstream signaling events of B Cell Receptor (BCR) (Caenorhabditis elegans)
Activation of RAS in B cells (Caenorhabditis elegans)
p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Caenorhabditis elegans)
GDP [cytosol]
Cytokine Signaling in Immune system (Caenorhabditis elegans)
FLT3 Signaling (Caenorhabditis elegans)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Caenorhabditis elegans)
GDP [cytosol]
Metabolism (Caenorhabditis elegans)
Integration of energy metabolism (Caenorhabditis elegans)
Regulation of insulin secretion (Caenorhabditis elegans)
Adrenaline,noradrenaline inhibits insulin secretion (Caenorhabditis elegans)
Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Caenorhabditis elegans)
GDP [cytosol]
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Caenorhabditis elegans)
RAP1A exchanges GDP for GTP (Caenorhabditis elegans)
GDP [cytosol]
Metabolism of carbohydrates (Caenorhabditis elegans)
Glucose metabolism (Caenorhabditis elegans)
Gluconeogenesis (Caenorhabditis elegans)
oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Caenorhabditis elegans)
GDP [cytosol]
Metabolism of nucleotides (Caenorhabditis elegans)
Nucleobase biosynthesis (Caenorhabditis elegans)
Purine ribonucleoside monophosphate biosynthesis (Caenorhabditis elegans)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Caenorhabditis elegans)
GDP [cytosol]
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Asparagine N-linked glycosylation (Caenorhabditis elegans)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Caenorhabditis elegans)
Addition of a second mannose to the N-glycan precursor by ALG2 (Caenorhabditis elegans)
GDP [cytosol]
Addition of the first mannose to the N-glycan precursor by ALG1 (Caenorhabditis elegans)
GDP [cytosol]
Transport to the Golgi and subsequent modification (Caenorhabditis elegans)
ER to Golgi Anterograde Transport (Caenorhabditis elegans)
COPII-mediated vesicle transport (Caenorhabditis elegans)
Nucleotide exchange on RAB1 (Caenorhabditis elegans)
GDP [cytosol]
SAR1 Activation And Membrane Binding (Caenorhabditis elegans)
GDP [cytosol]
Translation (Caenorhabditis elegans)
Eukaryotic Translation Initiation (Caenorhabditis elegans)
Cap-dependent Translation Initiation (Caenorhabditis elegans)
Recycling of eIF2:GDP (Caenorhabditis elegans)
eIF2 activation (Caenorhabditis elegans)
GDP [cytosol]
Organelle biogenesis and maintenance (Caenorhabditis elegans)
Cilium Assembly (Caenorhabditis elegans)
Cargo trafficking to the periciliary membrane (Caenorhabditis elegans)
VxPx cargo-targeting to cilium (Caenorhabditis elegans)
GBF1 stimulates nucleotide exchange on ARF4 (Caenorhabditis elegans)
GDP [cytosol]
Signal Transduction (Caenorhabditis elegans)
Death Receptor Signalling (Caenorhabditis elegans)
p75 NTR receptor-mediated signalling (Caenorhabditis elegans)
Cell death signalling via NRAGE, NRIF and NADE (Caenorhabditis elegans)
NRAGE signals death through JNK (Caenorhabditis elegans)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Caenorhabditis elegans)
GDP [cytosol]
Integrin signaling (Caenorhabditis elegans)
Activation of Rap1 by cytosolic GEFs (Caenorhabditis elegans)
GDP [cytosol]
Activation of Rap1 by membrane-associated GEFs (Caenorhabditis elegans)
GDP [cytosol]
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF/MAP kinase cascade (Caenorhabditis elegans)
Intrinsic nucleotide exchange on RAS (Caenorhabditis elegans)
GDP [cytosol]
RAS GEFs promote RAS nucleotide exchange (Caenorhabditis elegans)
GDP [cytosol]
RAS processing (Caenorhabditis elegans)
mature p21 RAS binds GDP (Caenorhabditis elegans)
GDP [cytosol]
MTOR signalling (Caenorhabditis elegans)
GTP loading by Rheb (Caenorhabditis elegans)
GDP [cytosol]
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (12/13) signalling events (Caenorhabditis elegans)
GEFs activate RhoA,B,C (Caenorhabditis elegans)
GDP [cytosol]
Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Caenorhabditis elegans)
GDP [cytosol]
p115-RhoGEF activation of RHOA (Caenorhabditis elegans)
GDP [cytosol]
G alpha (i) signalling events (Caenorhabditis elegans)
Liganded Gi-activating GPCR acts as a GEF for Gi (Caenorhabditis elegans)
GDP [cytosol]
Opioid Signalling (Caenorhabditis elegans)
G-protein activation (Caenorhabditis elegans)
G-protein alpha subunit is inactivated (Caenorhabditis elegans)
GDP [cytosol]
The receptor:G-protein complex releases GDP (Caenorhabditis elegans)
GDP [cytosol]
G alpha (q) signalling events (Caenorhabditis elegans)
Gastrin-CREB signalling pathway via PKC and MAPK (Caenorhabditis elegans)
EGFR Transactivation by Gastrin (Caenorhabditis elegans)
SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Caenorhabditis elegans)
GDP [cytosol]
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Caenorhabditis elegans)
GDP [cytosol]
G alpha (z) signalling events (Caenorhabditis elegans)
Liganded Gz-activating GPCR acts as a GEF for Gz (Caenorhabditis elegans)
GDP [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by PTK6 (Caenorhabditis elegans)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Caenorhabditis elegans)
Activation of RAC1 by the PXN:CRK complex (Caenorhabditis elegans)
GDP [cytosol]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by EGFR (Caenorhabditis elegans)
GRB2 events in EGFR signaling (Caenorhabditis elegans)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Caenorhabditis elegans)
GDP [cytosol]
Signaling by ERBB2 (Caenorhabditis elegans)
GRB2 events in ERBB2 signaling (Caenorhabditis elegans)
RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Caenorhabditis elegans)
GDP [cytosol]
Signaling by FGFR (Caenorhabditis elegans)
Signaling by FGFR2 (Caenorhabditis elegans)
Downstream signaling of activated FGFR2 (Caenorhabditis elegans)
FRS-mediated FGFR2 signaling (Caenorhabditis elegans)
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)
GDP [cytosol]
Signaling by FGFR3 (Caenorhabditis elegans)
Downstream signaling of activated FGFR3 (Caenorhabditis elegans)
FRS-mediated FGFR3 signaling (Caenorhabditis elegans)
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)
GDP [cytosol]
Signaling by MET (Caenorhabditis elegans)
MET activates RAS signaling (Caenorhabditis elegans)
RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Caenorhabditis elegans)
GDP [cytosol]
RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Caenorhabditis elegans)
GDP [cytosol]
MET promotes cell motility (Caenorhabditis elegans)
MET activates RAP1 and RAC1 (Caenorhabditis elegans)
DOCK7 activates RAC1 (Caenorhabditis elegans)
GDP [cytosol]
RAPGEF1 activates RAP1 (Caenorhabditis elegans)
GDP [cytosol]
Signaling by PDGF (Caenorhabditis elegans)
Downstream signal transduction (Caenorhabditis elegans)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Caenorhabditis elegans)
GDP [cytosol]
Signaling by SCF-KIT (Caenorhabditis elegans)
Activation of RAC1 (Caenorhabditis elegans)
GDP [cytosol]
Activation of RAS by p-KIT bound SOS1 (Caenorhabditis elegans)
GDP [cytosol]
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
VAV exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)
GDP [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Caenorhabditis elegans)
Signaling by Rho GTPases (Caenorhabditis elegans)
RHO GTPase cycle (Caenorhabditis elegans)
CDC42 GTPase cycle (Caenorhabditis elegans)
CDC42 GEFs activate CDC42 (Caenorhabditis elegans)
GDP [cytosol]
RAC1 GTPase cycle (Caenorhabditis elegans)
RAC1 GEFs activate RAC1 (Caenorhabditis elegans)
GDP [cytosol]
RAC2 GTPase cycle (Caenorhabditis elegans)
RAC2 GEFs activate RAC2 (Caenorhabditis elegans)
GDP [cytosol]
RHOA GTPase cycle (Caenorhabditis elegans)
RHOA GEFs activate RHOA (Caenorhabditis elegans)
GDP [cytosol]
RHOD GTPase cycle (Caenorhabditis elegans)
RHOD auto-activates (Caenorhabditis elegans)
GDP [cytosol]
RHOF GTPase cycle (Caenorhabditis elegans)
RHOF auto-activates (Caenorhabditis elegans)
GDP [cytosol]
RHOJ GTPase cycle (Caenorhabditis elegans)
RHOJ GEFs activate RHOJ (Caenorhabditis elegans)
GDP [cytosol]
RHOQ GTPase cycle (Caenorhabditis elegans)
RHOQ GEFs activate RHOQ (Caenorhabditis elegans)
GDP [cytosol]
RHOU GTPase cycle (Caenorhabditis elegans)
RHOU auto-activates (Caenorhabditis elegans)
GDP [cytosol]
RHOV GTPase cycle (Caenorhabditis elegans)
RHOV binds GTP (Caenorhabditis elegans)
GDP [cytosol]
Signaling by WNT (Caenorhabditis elegans)
Beta-catenin independent WNT signaling (Caenorhabditis elegans)
Ca2+ pathway (Caenorhabditis elegans)
WNT:FZD complex promotes G-protein nucleotide exchange (Caenorhabditis elegans)
GDP [cytosol]
Vesicle-mediated transport (Caenorhabditis elegans)
Membrane Trafficking (Caenorhabditis elegans)
ER to Golgi Anterograde Transport (Caenorhabditis elegans)
COPII-mediated vesicle transport (Caenorhabditis elegans)
Nucleotide exchange on RAB1 (Caenorhabditis elegans)
GDP [cytosol]
SAR1 Activation And Membrane Binding (Caenorhabditis elegans)
GDP [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Caenorhabditis elegans)
Golgi-to-ER retrograde transport (Caenorhabditis elegans)
COPI-dependent Golgi-to-ER retrograde traffic (Caenorhabditis elegans)
GBF1 stimulates nucleotide exchange on ARF (Caenorhabditis elegans)
GDP [cytosol]
COPI-independent Golgi-to-ER retrograde traffic (Caenorhabditis elegans)
RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Caenorhabditis elegans)
GDP [cytosol]
Retrograde transport at the Trans-Golgi-Network (Caenorhabditis elegans)
RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Caenorhabditis elegans)
GDP [cytosol]
Rab regulation of trafficking (Caenorhabditis elegans)
RAB GEFs exchange GTP for GDP on RABs (Caenorhabditis elegans)
DENND1s exchange GTP for GDP on RAB35 (Caenorhabditis elegans)
GDP [cytosol]
DENND3 exchanges GTP for GDP on RAB12 (Caenorhabditis elegans)
GDP [cytosol]
DENND4s exchange GTP for GDP on RAB10 (Caenorhabditis elegans)
GDP [cytosol]
DENND5A,B exchange GTP for GDP on RAB39 (Caenorhabditis elegans)
GDP [cytosol]
DENND6A,B exchange GTP for GDP on RAB14 (Caenorhabditis elegans)
GDP [cytosol]
MADD exchanges GTP for GDP on RAB27 (Caenorhabditis elegans)
GDP [cytosol]
MON1:CCZ1 exchanges GTP for GDP on RAB7 (Caenorhabditis elegans)
GDP [cytosol]
RAB13 GEFs exchange GTP for GDP on RAB13 (Caenorhabditis elegans)
GDP [cytosol]
RAB21 GEFs exchange GTP for GDP on RAB21 (Caenorhabditis elegans)
GDP [cytosol]
RAB3 GEFs exchange GTP for GDP on RAB3A (Caenorhabditis elegans)
GDP [cytosol]
RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Caenorhabditis elegans)
GDP [cytosol]
RAB5 GEFs exchange GTP for GDP on RAB5 (Caenorhabditis elegans)
GDP [cytosol]
RAB8 GEFs exchange GTP for GDP on RAB8 (Caenorhabditis elegans)
GDP [cytosol]
RIC1-RGP1 exchanges GTP for GDP on RAB6 (Caenorhabditis elegans)
GDP [cytosol]
TRAPPC complexes exchange GTP for GDP on RAB1 (Caenorhabditis elegans)
GDP [cytosol]
trans-Golgi Network Vesicle Budding (Caenorhabditis elegans)
Golgi Associated Vesicle Biogenesis (Caenorhabditis elegans)
trans-Golgi Network Vesicle Scission (Caenorhabditis elegans)
GDP [cytosol]
Lysosome Vesicle Biogenesis (Caenorhabditis elegans)
trans-Golgi Network Lysosomal Vesicle Scission (Caenorhabditis elegans)
GDP [cytosol]
trans-Golgi Network Coat Activation (Caenorhabditis elegans)
GDP [cytosol]
Cell Cycle (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
M Phase (Canis familiaris)
Mitotic Metaphase and Anaphase (Canis familiaris)
Mitotic Anaphase (Canis familiaris)
Nuclear Envelope (NE) Reassembly (Canis familiaris)
Postmitotic nuclear pore complex (NPC) reformation (Canis familiaris)
RCC1 stimulates GDP to GTP exchange on RAN (Canis familiaris)
GDP [cytosol]
Cellular responses to external stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to starvation (Canis familiaris)
Amino acids regulate mTORC1 (Canis familiaris)
RRAGA,B exchanges GDP for GTP (Canis familiaris)
GDP [cytosol]
RRAGC,D exchanges GTP for GDP (Canis familiaris)
GDP [cytosol]
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
EPH-Ephrin signaling (Canis familiaris)
EPH-ephrin mediated repulsion of cells (Canis familiaris)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
GDP [cytosol]
VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
GDP [cytosol]
EPHA-mediated growth cone collapse (Canis familiaris)
NGEF exchanges GTP for GDP on RHOA (Canis familiaris)
GDP [cytosol]
EPHB-mediated forward signaling (Canis familiaris)
p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
GDP [cytosol]
p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Canis familiaris)
GDP [cytosol]
L1CAM interactions (Canis familiaris)
Recycling pathway of L1 (Canis familiaris)
Formation of clathrin coated vesicle (Canis familiaris)
GDP [cytosol]
Signal transduction by L1 (Canis familiaris)
Activation of Rac1 by VAV2 (Canis familiaris)
GDP [cytosol]
NCAM signaling for neurite out-growth (Canis familiaris)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Canis familiaris)
GDP [cytosol]
Netrin-1 signaling (Canis familiaris)
DCC mediated attractive signaling (Canis familiaris)
Activation of Cdc42 (Canis familiaris)
GDP [cytosol]
Activation of Rac1 (Canis familiaris)
GDP [cytosol]
Semaphorin interactions (Canis familiaris)
Sema4D in semaphorin signaling (Canis familiaris)
Sema4D induced cell migration and growth-cone collapse (Canis familiaris)
Activation of Rho by LARG and PDZ-RhoGEF (Canis familiaris)
GDP [cytosol]
Hemostasis (Canis familiaris)
Cell surface interactions at the vascular wall (Canis familiaris)
Tie2 Signaling (Canis familiaris)
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Canis familiaris)
GDP [cytosol]
Platelet activation, signaling and aggregation (Canis familiaris)
GPVI-mediated activation cascade (Canis familiaris)
VAV1 is a GEF for Rho/Rac family GTPases (Canis familiaris)
GDP [cytosol]
VAV2 is a GEF for Rho/Rac family kinases (Canis familiaris)
GDP [cytosol]
VAV3 is a GEF for Rho/Rac family kinases (Canis familiaris)
GDP [cytosol]
Platelet Aggregation (Plug Formation) (Canis familiaris)
Integrin signaling (Canis familiaris)
Activation of Rap1 by cytosolic GEFs (Canis familiaris)
GDP [cytosol]
Activation of Rap1 by membrane-associated GEFs (Canis familiaris)
GDP [cytosol]
Signal amplification (Canis familiaris)
ADP signalling through P2Y purinoceptor 12 (Canis familiaris)
Gi activation by P2Y purinoceptor 12 (Canis familiaris)
GDP [cytosol]
Thromboxane signalling through TP receptor (Canis familiaris)
G13 activation by TP receptor (Canis familiaris)
GDP [cytosol]
Gq activation by TP receptor (Canis familiaris)
GDP [cytosol]
Thrombin signalling through proteinase activated receptors (PARs) (Canis familiaris)
Thrombin-activated PARs activate G12/13 (Canis familiaris)
GDP [cytosol]
Thrombin-activated PARs activate Gq (Canis familiaris)
GDP [cytosol]
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Costimulation by the CD28 family (Canis familiaris)
CD28 co-stimulation (Canis familiaris)
CD28 dependent Vav1 pathway (Canis familiaris)
Activation of Cdc42 by pVav1 (Canis familiaris)
GDP [cytosol]
Activation of Rac1 by pVav1 (Canis familiaris)
GDP [cytosol]
MHC class II antigen presentation (Canis familiaris)
Internalization of MHC II:Ii clathrin coated vesicle (Canis familiaris)
GDP [cytosol]
Translocation of TGN-lysosome vesicle to lysosome (Canis familiaris)
GDP [cytosol]
Rap1 signalling (Canis familiaris)
Activation of Rap1 by cytosolic GEFs (Canis familiaris)
GDP [cytosol]
Activation of Rap1 by membrane-associated GEFs (Canis familiaris)
GDP [cytosol]
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Downstream signaling events of B Cell Receptor (BCR) (Canis familiaris)
Activation of RAS in B cells (Canis familiaris)
p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Canis familiaris)
GDP [cytosol]
Cytokine Signaling in Immune system (Canis familiaris)
FLT3 Signaling (Canis familiaris)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Canis familiaris)
GDP [cytosol]
Innate Immune System (Canis familiaris)
DAP12 interactions (Canis familiaris)
DAP12 signaling (Canis familiaris)
Activation of RAC1 by VAV2/3 (Canis familiaris)
GDP [cytosol]
SOS mediated nucleotide exchange of RAS (SHC) (Canis familiaris)
GDP [cytosol]
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated MAPK activation (Canis familiaris)
Activation of RAC1 by VAV (Canis familiaris)
GDP [cytosol]
SOS mediated nucleotide exchange of RAS (SHC) (Canis familiaris)
GDP [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
Activation of RAC1 by CRKII:DOCK180:ELMO (Canis familiaris)
GDP [cytosol]
Activation of RAC1 by VAV (Canis familiaris)
GDP [cytosol]
Metabolism (Canis familiaris)
Integration of energy metabolism (Canis familiaris)
Regulation of insulin secretion (Canis familiaris)
Adrenaline,noradrenaline inhibits insulin secretion (Canis familiaris)
Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Canis familiaris)
GDP [cytosol]
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Canis familiaris)
RAP1A exchanges GDP for GTP (Canis familiaris)
GDP [cytosol]
Metabolism of carbohydrates (Canis familiaris)
Glucose metabolism (Canis familiaris)
Gluconeogenesis (Canis familiaris)
oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Canis familiaris)
GDP [cytosol]
Metabolism of nucleotides (Canis familiaris)
Nucleobase biosynthesis (Canis familiaris)
Purine ribonucleoside monophosphate biosynthesis (Canis familiaris)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Canis familiaris)
GDP [cytosol]
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Asparagine N-linked glycosylation (Canis familiaris)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Canis familiaris)
Addition of a second mannose to the N-glycan precursor by ALG2 (Canis familiaris)
GDP [cytosol]
Addition of the first mannose to the N-glycan precursor by ALG1 (Canis familiaris)
GDP [cytosol]
Transport to the Golgi and subsequent modification (Canis familiaris)
ER to Golgi Anterograde Transport (Canis familiaris)
COPII-mediated vesicle transport (Canis familiaris)
Nucleotide exchange on RAB1 (Canis familiaris)
GDP [cytosol]
SAR1 Activation And Membrane Binding (Canis familiaris)
GDP [cytosol]
Translation (Canis familiaris)
Eukaryotic Translation Initiation (Canis familiaris)
Cap-dependent Translation Initiation (Canis familiaris)
Recycling of eIF2:GDP (Canis familiaris)
eIF2 activation (Canis familiaris)
GDP [cytosol]
Organelle biogenesis and maintenance (Canis familiaris)
Cilium Assembly (Canis familiaris)
Anchoring of the basal body to the plasma membrane (Canis familiaris)
RAB3IP stimulates nucleotide exchange on RAB8A (Canis familiaris)
GDP [cytosol]
Cargo trafficking to the periciliary membrane (Canis familiaris)
VxPx cargo-targeting to cilium (Canis familiaris)
GBF1 stimulates nucleotide exchange on ARF4 (Canis familiaris)
GDP [cytosol]
RAB3IP stimulates nucleotide exchange on RAB8A (Canis familiaris)
GDP [cytosol]
Signal Transduction (Canis familiaris)
Death Receptor Signalling (Canis familiaris)
p75 NTR receptor-mediated signalling (Canis familiaris)
Cell death signalling via NRAGE, NRIF and NADE (Canis familiaris)
NRAGE signals death through JNK (Canis familiaris)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Canis familiaris)
GDP [cytosol]
Integrin signaling (Canis familiaris)
Activation of Rap1 by cytosolic GEFs (Canis familiaris)
GDP [cytosol]
Activation of Rap1 by membrane-associated GEFs (Canis familiaris)
GDP [cytosol]
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
Intrinsic nucleotide exchange on RAS (Canis familiaris)
GDP [cytosol]
RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
GDP [cytosol]
RAS processing (Canis familiaris)
mature p21 RAS binds GDP (Canis familiaris)
GDP [cytosol]
MTOR signalling (Canis familiaris)
GTP loading by Rheb (Canis familiaris)
GDP [cytosol]
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (12/13) signalling events (Canis familiaris)
GEFs activate RhoA,B,C (Canis familiaris)
GDP [cytosol]
Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Canis familiaris)
GDP [cytosol]
p115-RhoGEF activation of RHOA (Canis familiaris)
GDP [cytosol]
G alpha (i) signalling events (Canis familiaris)
Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
GDP [cytosol]
Opioid Signalling (Canis familiaris)
G-protein activation (Canis familiaris)
G-protein alpha subunit is inactivated (Canis familiaris)
GDP [cytosol]
The receptor:G-protein complex releases GDP (Canis familiaris)
GDP [cytosol]
Opsins act as GEFs for G alpha-t (Canis familiaris)
GDP [cytosol]
G alpha (q) signalling events (Canis familiaris)
Gastrin-CREB signalling pathway via PKC and MAPK (Canis familiaris)
EGFR Transactivation by Gastrin (Canis familiaris)
SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Canis familiaris)
GDP [cytosol]
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Canis familiaris)
GDP [cytosol]
G alpha (s) signalling events (Canis familiaris)
Liganded Gs-activating GPCR acts as a GEF for Gs (Canis familiaris)
GDP [cytosol]
G alpha (z) signalling events (Canis familiaris)
Liganded Gz-activating GPCR acts as a GEF for Gz (Canis familiaris)
GDP [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Canis familiaris)
Signaling by PTK6 (Canis familiaris)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Canis familiaris)
Activation of RAC1 by the PXN:CRK complex (Canis familiaris)
GDP [cytosol]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by EGFR (Canis familiaris)
GRB2 events in EGFR signaling (Canis familiaris)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Canis familiaris)
GDP [cytosol]
SHC1 events in EGFR signaling (Canis familiaris)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Canis familiaris)
GDP [cytosol]
Signaling by ERBB2 (Canis familiaris)
GRB2 events in ERBB2 signaling (Canis familiaris)
RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Canis familiaris)
GDP [cytosol]
Signaling by ERBB4 (Canis familiaris)
SHC1 events in ERBB4 signaling (Canis familiaris)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Canis familiaris)
GDP [cytosol]
Signaling by FGFR (Canis familiaris)
Signaling by FGFR1 (Canis familiaris)
Downstream signaling of activated FGFR1 (Canis familiaris)
FRS-mediated FGFR1 signaling (Canis familiaris)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)
GDP [cytosol]
Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)
GDP [cytosol]
SHC-mediated cascade:FGFR1 (Canis familiaris)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)
GDP [cytosol]
Signaling by FGFR2 (Canis familiaris)
Downstream signaling of activated FGFR2 (Canis familiaris)
FRS-mediated FGFR2 signaling (Canis familiaris)
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)
GDP [cytosol]
Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)
GDP [cytosol]
SHC-mediated cascade:FGFR2 (Canis familiaris)
Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)
GDP [cytosol]
Signaling by FGFR3 (Canis familiaris)
Downstream signaling of activated FGFR3 (Canis familiaris)
FRS-mediated FGFR3 signaling (Canis familiaris)
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)
GDP [cytosol]
Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)
GDP [cytosol]
SHC-mediated cascade:FGFR3 (Canis familiaris)
Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)
GDP [cytosol]
Signaling by FGFR4 (Canis familiaris)
Downstream signaling of activated FGFR4 (Canis familiaris)
FRS-mediated FGFR4 signaling (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)
GDP [cytosol]
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)
GDP [cytosol]
SHC-mediated cascade:FGFR4 (Canis familiaris)
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)
GDP [cytosol]
Signaling by MET (Canis familiaris)
MET activates RAS signaling (Canis familiaris)
RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Canis familiaris)
GDP [cytosol]
RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Canis familiaris)
GDP [cytosol]
RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Canis familiaris)
GDP [cytosol]
MET promotes cell motility (Canis familiaris)
MET activates RAP1 and RAC1 (Canis familiaris)
DOCK7 activates RAC1 (Canis familiaris)
GDP [cytosol]
RAPGEF1 activates RAP1 (Canis familiaris)
GDP [cytosol]
Signaling by NTRKs (Canis familiaris)
Signaling by NTRK1 (TRKA) (Canis familiaris)
Signalling to ERKs (Canis familiaris)
Prolonged ERK activation events (Canis familiaris)
ARMS-mediated activation (Canis familiaris)
C3G stimulates nucleotide exchange on Rap1 (Canis familiaris)
GDP [cytosol]
Signaling by NTRK2 (TRKB) (Canis familiaris)
Activated NTRK2 signals through FYN (Canis familiaris)
NTRK2 activates RAC1 (Canis familiaris)
DOCK3 activates RAC1 (Canis familiaris)
GDP [cytosol]
Signaling by PDGF (Canis familiaris)
Downstream signal transduction (Canis familiaris)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Canis familiaris)
GDP [cytosol]
Signaling by SCF-KIT (Canis familiaris)
Activation of RAC1 (Canis familiaris)
GDP [cytosol]
Activation of RAS by p-KIT bound SOS1 (Canis familiaris)
GDP [cytosol]
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Canis familiaris)
GDP [cytosol]
VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
GDP [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase cycle (Canis familiaris)
CDC42 GTPase cycle (Canis familiaris)
CDC42 GEFs activate CDC42 (Canis familiaris)
GDP [cytosol]
RAC1 GTPase cycle (Canis familiaris)
RAC1 GEFs activate RAC1 (Canis familiaris)
GDP [cytosol]
RAC2 GTPase cycle (Canis familiaris)
RAC2 GEFs activate RAC2 (Canis familiaris)
GDP [cytosol]
RHOA GTPase cycle (Canis familiaris)
RHOA GEFs activate RHOA (Canis familiaris)
GDP [cytosol]
RHOB GTPase cycle (Canis familiaris)
RHOB GEFs activate RHOB (Canis familiaris)
GDP [cytosol]
RHOC GTPase cycle (Canis familiaris)
RHOC GEFs activate RHOC (Canis familiaris)
GDP [cytosol]
RHOD GTPase cycle (Canis familiaris)
RHOD auto-activates (Canis familiaris)
GDP [cytosol]
RHOF GTPase cycle (Canis familiaris)
RHOF auto-activates (Canis familiaris)
GDP [cytosol]
RHOG GTPase cycle (Canis familiaris)
RHOG GEFs activate RHOG (Canis familiaris)
GDP [cytosol]
RHOJ GTPase cycle (Canis familiaris)
RHOJ GEFs activate RHOJ (Canis familiaris)
GDP [cytosol]
RHOU GTPase cycle (Canis familiaris)
RHOU auto-activates (Canis familiaris)
GDP [cytosol]
RHOV GTPase cycle (Canis familiaris)
RHOV binds GTP (Canis familiaris)
GDP [cytosol]
Signaling by WNT (Canis familiaris)
Beta-catenin independent WNT signaling (Canis familiaris)
Ca2+ pathway (Canis familiaris)
WNT:FZD complex promotes G-protein nucleotide exchange (Canis familiaris)
GDP [cytosol]
Transport of small molecules (Canis familiaris)
Aquaporin-mediated transport (Canis familiaris)
Vasopressin regulates renal water homeostasis via Aquaporins (Canis familiaris)
AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Canis familiaris)
GDP [cytosol]
Vesicle-mediated transport (Canis familiaris)
Membrane Trafficking (Canis familiaris)
ER to Golgi Anterograde Transport (Canis familiaris)
COPII-mediated vesicle transport (Canis familiaris)
Nucleotide exchange on RAB1 (Canis familiaris)
GDP [cytosol]
SAR1 Activation And Membrane Binding (Canis familiaris)
GDP [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Canis familiaris)
Golgi-to-ER retrograde transport (Canis familiaris)
COPI-dependent Golgi-to-ER retrograde traffic (Canis familiaris)
GBF1 stimulates nucleotide exchange on ARF (Canis familiaris)
GDP [cytosol]
COPI-independent Golgi-to-ER retrograde traffic (Canis familiaris)
RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Canis familiaris)
GDP [cytosol]
Retrograde transport at the Trans-Golgi-Network (Canis familiaris)
RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Canis familiaris)
GDP [cytosol]
Rab regulation of trafficking (Canis familiaris)
RAB GEFs exchange GTP for GDP on RABs (Canis familiaris)
DENND1s exchange GTP for GDP on RAB35 (Canis familiaris)
GDP [cytosol]
DENND5A,B exchange GTP for GDP on RAB39 (Canis familiaris)
GDP [cytosol]
DENND6A,B exchange GTP for GDP on RAB14 (Canis familiaris)
GDP [cytosol]
HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Canis familiaris)
GDP [cytosol]
MADD exchanges GTP for GDP on RAB27 (Canis familiaris)
GDP [cytosol]
MON1:CCZ1 exchanges GTP for GDP on RAB7 (Canis familiaris)
GDP [cytosol]
RAB13 GEFs exchange GTP for GDP on RAB13 (Canis familiaris)
GDP [cytosol]
RAB3 GEFs exchange GTP for GDP on RAB3A (Canis familiaris)
GDP [cytosol]
RAB31 GEFs exchange GTP for GDP on RAB31 (Canis familiaris)
GDP [cytosol]
RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Canis familiaris)
GDP [cytosol]
RAB5 GEFs exchange GTP for GDP on RAB5 (Canis familiaris)
GDP [cytosol]
RAB8 GEFs exchange GTP for GDP on RAB8 (Canis familiaris)
GDP [cytosol]
RAB9 GEFs exchange GTP for GDP on RAB9 (Canis familiaris)
GDP [cytosol]
RIC1-RGP1 exchanges GTP for GDP on RAB6 (Canis familiaris)
GDP [cytosol]
TRAPPC complexes exchange GTP for GDP on RAB1 (Canis familiaris)
GDP [cytosol]
trans-Golgi Network Vesicle Budding (Canis familiaris)
Golgi Associated Vesicle Biogenesis (Canis familiaris)
trans-Golgi Network Vesicle Scission (Canis familiaris)
GDP [cytosol]
Lysosome Vesicle Biogenesis (Canis familiaris)
trans-Golgi Network Lysosomal Vesicle Scission (Canis familiaris)
GDP [cytosol]
trans-Golgi Network Coat Activation (Canis familiaris)
GDP [cytosol]
Cell Cycle (Danio rerio)
Cell Cycle, Mitotic (Danio rerio)
M Phase (Danio rerio)
Mitotic Metaphase and Anaphase (Danio rerio)
Mitotic Anaphase (Danio rerio)
Nuclear Envelope (NE) Reassembly (Danio rerio)
Postmitotic nuclear pore complex (NPC) reformation (Danio rerio)
RCC1 stimulates GDP to GTP exchange on RAN (Danio rerio)
GDP [cytosol]
Cellular responses to external stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to starvation (Danio rerio)
Amino acids regulate mTORC1 (Danio rerio)
RRAGA,B exchanges GDP for GTP (Danio rerio)
GDP [cytosol]
RRAGC,D exchanges GTP for GDP (Danio rerio)
GDP [cytosol]
Developmental Biology (Danio rerio)
Nervous system development (Danio rerio)
Axon guidance (Danio rerio)
EPH-Ephrin signaling (Danio rerio)
EPH-ephrin mediated repulsion of cells (Danio rerio)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Danio rerio)
GDP [cytosol]
VAV exchanges GTP for GDP on RAC1, activating it (Danio rerio)
GDP [cytosol]
EPHA-mediated growth cone collapse (Danio rerio)
NGEF exchanges GTP for GDP on RHOA (Danio rerio)
GDP [cytosol]
EPHB-mediated forward signaling (Danio rerio)
p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Danio rerio)
GDP [cytosol]
p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Danio rerio)
GDP [cytosol]
L1CAM interactions (Danio rerio)
Recycling pathway of L1 (Danio rerio)
Formation of clathrin coated vesicle (Danio rerio)
GDP [cytosol]
Signal transduction by L1 (Danio rerio)
Activation of Rac1 by VAV2 (Danio rerio)
GDP [cytosol]
NCAM signaling for neurite out-growth (Danio rerio)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Danio rerio)
GDP [cytosol]
Netrin-1 signaling (Danio rerio)
DCC mediated attractive signaling (Danio rerio)
Activation of Cdc42 (Danio rerio)
GDP [cytosol]
Activation of Rac1 (Danio rerio)
GDP [cytosol]
Semaphorin interactions (Danio rerio)
Sema4D in semaphorin signaling (Danio rerio)
Sema4D induced cell migration and growth-cone collapse (Danio rerio)
Activation of Rho by LARG and PDZ-RhoGEF (Danio rerio)
GDP [cytosol]
Hemostasis (Danio rerio)
Cell surface interactions at the vascular wall (Danio rerio)
Tie2 Signaling (Danio rerio)
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Danio rerio)
GDP [cytosol]
Platelet activation, signaling and aggregation (Danio rerio)
GPVI-mediated activation cascade (Danio rerio)
VAV2 is a GEF for Rho/Rac family kinases (Danio rerio)
GDP [cytosol]
VAV3 is a GEF for Rho/Rac family kinases (Danio rerio)
GDP [cytosol]
Platelet Aggregation (Plug Formation) (Danio rerio)
Integrin signaling (Danio rerio)
Activation of Rap1 by cytosolic GEFs (Danio rerio)
GDP [cytosol]
Activation of Rap1 by membrane-associated GEFs (Danio rerio)
GDP [cytosol]
Signal amplification (Danio rerio)
ADP signalling through P2Y purinoceptor 12 (Danio rerio)
Gi activation by P2Y purinoceptor 12 (Danio rerio)
GDP [cytosol]
Thromboxane signalling through TP receptor (Danio rerio)
G13 activation by TP receptor (Danio rerio)
GDP [cytosol]
Gq activation by TP receptor (Danio rerio)
GDP [cytosol]
Thrombin signalling through proteinase activated receptors (PARs) (Danio rerio)
Thrombin-activated PARs activate G12/13 (Danio rerio)
GDP [cytosol]
Thrombin-activated PARs activate Gq (Danio rerio)
GDP [cytosol]
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
Class I MHC mediated antigen processing & presentation (Danio rerio)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Danio rerio)
Disassembly of COPII coated vesicle (Danio rerio)
GDP [cytosol]
Costimulation by the CD28 family (Danio rerio)
CD28 co-stimulation (Danio rerio)
CD28 dependent Vav1 pathway (Danio rerio)
Activation of Cdc42 by pVav1 (Danio rerio)
GDP [cytosol]
Activation of Rac1 by pVav1 (Danio rerio)
GDP [cytosol]
MHC class II antigen presentation (Danio rerio)
Internalization of MHC II:Ii clathrin coated vesicle (Danio rerio)
GDP [cytosol]
Translocation of TGN-lysosome vesicle to lysosome (Danio rerio)
GDP [cytosol]
Rap1 signalling (Danio rerio)
Activation of Rap1 by cytosolic GEFs (Danio rerio)
GDP [cytosol]
Activation of Rap1 by membrane-associated GEFs (Danio rerio)
GDP [cytosol]
Signaling by the B Cell Receptor (BCR) (Danio rerio)
Downstream signaling events of B Cell Receptor (BCR) (Danio rerio)
Activation of RAS in B cells (Danio rerio)
p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Danio rerio)
GDP [cytosol]
Innate Immune System (Danio rerio)
DAP12 interactions (Danio rerio)
DAP12 signaling (Danio rerio)
Activation of RAC1 by VAV2/3 (Danio rerio)
GDP [cytosol]
Fc epsilon receptor (FCERI) signaling (Danio rerio)
FCERI mediated MAPK activation (Danio rerio)
Activation of RAC1 by VAV (Danio rerio)
GDP [cytosol]
Metabolism (Danio rerio)
Integration of energy metabolism (Danio rerio)
Regulation of insulin secretion (Danio rerio)
Adrenaline,noradrenaline inhibits insulin secretion (Danio rerio)
Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Danio rerio)
GDP [cytosol]
Free fatty acids regulate insulin secretion (Danio rerio)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Danio rerio)
GPR40:fatty acid activates Gq (Danio rerio)
GDP [cytosol]
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Danio rerio)
RAP1A exchanges GDP for GTP (Danio rerio)
GDP [cytosol]
Metabolism of carbohydrates (Danio rerio)
Glucose metabolism (Danio rerio)
Gluconeogenesis (Danio rerio)
oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Danio rerio)
GDP [cytosol]
Metabolism of nucleotides (Danio rerio)
Nucleobase biosynthesis (Danio rerio)
Purine ribonucleoside monophosphate biosynthesis (Danio rerio)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Danio rerio)
GDP [cytosol]
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Asparagine N-linked glycosylation (Danio rerio)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Danio rerio)
Addition of a second mannose to the N-glycan precursor by ALG2 (Danio rerio)
GDP [cytosol]
Addition of the first mannose to the N-glycan precursor by ALG1 (Danio rerio)
GDP [cytosol]
Synthesis of substrates in N-glycan biosythesis (Danio rerio)
Synthesis of dolichyl-phosphate mannose (Danio rerio)
dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Danio rerio)
GDP [cytosol]
Transport to the Golgi and subsequent modification (Danio rerio)
ER to Golgi Anterograde Transport (Danio rerio)
COPII-mediated vesicle transport (Danio rerio)
Nucleotide exchange on RAB1 (Danio rerio)
GDP [cytosol]
SAR1 Activation And Membrane Binding (Danio rerio)
GDP [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Danio rerio)
Synthesis of dolichyl-phosphate mannose (Danio rerio)
dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Danio rerio)
GDP [cytosol]
Translation (Danio rerio)
Eukaryotic Translation Initiation (Danio rerio)
Cap-dependent Translation Initiation (Danio rerio)
Recycling of eIF2:GDP (Danio rerio)
eIF2 activation (Danio rerio)
GDP [cytosol]
Organelle biogenesis and maintenance (Danio rerio)
Cilium Assembly (Danio rerio)
Anchoring of the basal body to the plasma membrane (Danio rerio)
RAB3IP stimulates nucleotide exchange on RAB8A (Danio rerio)
GDP [cytosol]
Cargo trafficking to the periciliary membrane (Danio rerio)
VxPx cargo-targeting to cilium (Danio rerio)
GBF1 stimulates nucleotide exchange on ARF4 (Danio rerio)
GDP [cytosol]
RAB3IP stimulates nucleotide exchange on RAB8A (Danio rerio)
GDP [cytosol]
Signal Transduction (Danio rerio)
Death Receptor Signalling (Danio rerio)
p75 NTR receptor-mediated signalling (Danio rerio)
Cell death signalling via NRAGE, NRIF and NADE (Danio rerio)
NRAGE signals death through JNK (Danio rerio)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Danio rerio)
GDP [cytosol]
Integrin signaling (Danio rerio)
Activation of Rap1 by cytosolic GEFs (Danio rerio)
GDP [cytosol]
Activation of Rap1 by membrane-associated GEFs (Danio rerio)
GDP [cytosol]
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
Intrinsic nucleotide exchange on RAS (Danio rerio)
GDP [cytosol]
RAS GEFs promote RAS nucleotide exchange (Danio rerio)
GDP [cytosol]
RAS processing (Danio rerio)
mature p21 RAS binds GDP (Danio rerio)
GDP [cytosol]
MTOR signalling (Danio rerio)
GTP loading by Rheb (Danio rerio)
GDP [cytosol]
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (12/13) signalling events (Danio rerio)
GEFs activate RhoA,B,C (Danio rerio)
GDP [cytosol]
Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Danio rerio)
GDP [cytosol]
p115-RhoGEF activation of RHOA (Danio rerio)
GDP [cytosol]
G alpha (i) signalling events (Danio rerio)
Liganded Gi-activating GPCR acts as a GEF for Gi (Danio rerio)
GDP [cytosol]
Opioid Signalling (Danio rerio)
G-protein activation (Danio rerio)
G-protein alpha subunit is inactivated (Danio rerio)
GDP [cytosol]
The receptor:G-protein complex releases GDP (Danio rerio)
GDP [cytosol]
Opsins act as GEFs for G alpha-t (Danio rerio)
GDP [cytosol]
G alpha (q) signalling events (Danio rerio)
Gastrin-CREB signalling pathway via PKC and MAPK (Danio rerio)
EGFR Transactivation by Gastrin (Danio rerio)
SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Danio rerio)
GDP [cytosol]
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Danio rerio)
GDP [cytosol]
G alpha (s) signalling events (Danio rerio)
Liganded Gs-activating GPCR acts as a GEF for Gs (Danio rerio)
GDP [cytosol]
G alpha (z) signalling events (Danio rerio)
Liganded Gz-activating GPCR acts as a GEF for Gz (Danio rerio)
GDP [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Danio rerio)
Signaling by PTK6 (Danio rerio)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Danio rerio)
Activation of RAC1 by the PXN:CRK complex (Danio rerio)
GDP [cytosol]
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by EGFR (Danio rerio)
GRB2 events in EGFR signaling (Danio rerio)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Danio rerio)
GDP [cytosol]
SHC1 events in EGFR signaling (Danio rerio)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Danio rerio)
GDP [cytosol]
Signaling by ERBB2 (Danio rerio)
GRB2 events in ERBB2 signaling (Danio rerio)
RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Danio rerio)
GDP [cytosol]
Signaling by ERBB4 (Danio rerio)
SHC1 events in ERBB4 signaling (Danio rerio)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Danio rerio)
GDP [cytosol]
Signaling by FGFR (Danio rerio)
Signaling by FGFR1 (Danio rerio)
Downstream signaling of activated FGFR1 (Danio rerio)
FRS-mediated FGFR1 signaling (Danio rerio)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
GDP [cytosol]
Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)
GDP [cytosol]
SHC-mediated cascade:FGFR1 (Danio rerio)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
GDP [cytosol]
Signaling by FGFR2 (Danio rerio)
Downstream signaling of activated FGFR2 (Danio rerio)
FRS-mediated FGFR2 signaling (Danio rerio)
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
GDP [cytosol]
Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)
GDP [cytosol]
SHC-mediated cascade:FGFR2 (Danio rerio)
Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
GDP [cytosol]
Signaling by FGFR3 (Danio rerio)
Downstream signaling of activated FGFR3 (Danio rerio)
FRS-mediated FGFR3 signaling (Danio rerio)
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
GDP [cytosol]
Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)
GDP [cytosol]
SHC-mediated cascade:FGFR3 (Danio rerio)
Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
GDP [cytosol]
Signaling by FGFR4 (Danio rerio)
Downstream signaling of activated FGFR4 (Danio rerio)
FRS-mediated FGFR4 signaling (Danio rerio)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
GDP [cytosol]
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)
GDP [cytosol]
SHC-mediated cascade:FGFR4 (Danio rerio)
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
GDP [cytosol]
Signaling by MET (Danio rerio)
MET activates RAS signaling (Danio rerio)
RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Danio rerio)
GDP [cytosol]
RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Danio rerio)
GDP [cytosol]
RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Danio rerio)
GDP [cytosol]
MET promotes cell motility (Danio rerio)
MET activates RAP1 and RAC1 (Danio rerio)
DOCK7 activates RAC1 (Danio rerio)
GDP [cytosol]
RAPGEF1 activates RAP1 (Danio rerio)
GDP [cytosol]
Signaling by NTRKs (Danio rerio)
Signaling by NTRK1 (TRKA) (Danio rerio)
Signalling to ERKs (Danio rerio)
Prolonged ERK activation events (Danio rerio)
ARMS-mediated activation (Danio rerio)
C3G stimulates nucleotide exchange on Rap1 (Danio rerio)
GDP [cytosol]
Signaling by NTRK2 (TRKB) (Danio rerio)
Activated NTRK2 signals through FYN (Danio rerio)
NTRK2 activates RAC1 (Danio rerio)
DOCK3 activates RAC1 (Danio rerio)
GDP [cytosol]
Signaling by PDGF (Danio rerio)
Downstream signal transduction (Danio rerio)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Danio rerio)
GDP [cytosol]
Signaling by SCF-KIT (Danio rerio)
Activation of RAS by p-KIT bound SOS1 (Danio rerio)
GDP [cytosol]
Signaling by VEGF (Danio rerio)
VEGFA-VEGFR2 Pathway (Danio rerio)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Danio rerio)
GDP [cytosol]
VAV exchanges GTP for GDP on RAC1, activating it (Danio rerio)
GDP [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
Signaling by Rho GTPases (Danio rerio)
RHO GTPase cycle (Danio rerio)
CDC42 GTPase cycle (Danio rerio)
CDC42 GEFs activate CDC42 (Danio rerio)
GDP [cytosol]
RAC1 GTPase cycle (Danio rerio)
RAC1 GEFs activate RAC1 (Danio rerio)
GDP [cytosol]
RAC2 GTPase cycle (Danio rerio)
RAC2 GEFs activate RAC2 (Danio rerio)
GDP [cytosol]
RAC3 GTPase cycle (Danio rerio)
RAC3 GEFs activate RAC3 (Danio rerio)
GDP [cytosol]
RHOA GTPase cycle (Danio rerio)
RHOA GEFs activate RHOA (Danio rerio)
GDP [cytosol]
RHOC GTPase cycle (Danio rerio)
RHOC GEFs activate RHOC (Danio rerio)
GDP [cytosol]
RHOD GTPase cycle (Danio rerio)
RHOD auto-activates (Danio rerio)
GDP [cytosol]
RHOF GTPase cycle (Danio rerio)
RHOF auto-activates (Danio rerio)
GDP [cytosol]
RHOG GTPase cycle (Danio rerio)
RHOG GEFs activate RHOG (Danio rerio)
GDP [cytosol]
RHOJ GTPase cycle (Danio rerio)
RHOJ GEFs activate RHOJ (Danio rerio)
GDP [cytosol]
RHOQ GTPase cycle (Danio rerio)
RHOQ GEFs activate RHOQ (Danio rerio)
GDP [cytosol]
RHOU GTPase cycle (Danio rerio)
RHOU auto-activates (Danio rerio)
GDP [cytosol]
RHOV GTPase cycle (Danio rerio)
RHOV binds GTP (Danio rerio)
GDP [cytosol]
Signaling by WNT (Danio rerio)
Beta-catenin independent WNT signaling (Danio rerio)
Ca2+ pathway (Danio rerio)
WNT:FZD complex promotes G-protein nucleotide exchange (Danio rerio)
GDP [cytosol]
Transport of small molecules (Danio rerio)
Aquaporin-mediated transport (Danio rerio)
Vasopressin regulates renal water homeostasis via Aquaporins (Danio rerio)
AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Danio rerio)
GDP [cytosol]
Vesicle-mediated transport (Danio rerio)
Membrane Trafficking (Danio rerio)
ER to Golgi Anterograde Transport (Danio rerio)
COPII-mediated vesicle transport (Danio rerio)
Nucleotide exchange on RAB1 (Danio rerio)
GDP [cytosol]
SAR1 Activation And Membrane Binding (Danio rerio)
GDP [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Danio rerio)
Golgi-to-ER retrograde transport (Danio rerio)
COPI-dependent Golgi-to-ER retrograde traffic (Danio rerio)
GBF1 stimulates nucleotide exchange on ARF (Danio rerio)
GDP [cytosol]
COPI-independent Golgi-to-ER retrograde traffic (Danio rerio)
RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Danio rerio)
GDP [cytosol]
Rab regulation of trafficking (Danio rerio)
RAB GEFs exchange GTP for GDP on RABs (Danio rerio)
DENND1s exchange GTP for GDP on RAB35 (Danio rerio)
GDP [cytosol]
DENND3 exchanges GTP for GDP on RAB12 (Danio rerio)
GDP [cytosol]
DENND4s exchange GTP for GDP on RAB10 (Danio rerio)
GDP [cytosol]
DENND6A,B exchange GTP for GDP on RAB14 (Danio rerio)
GDP [cytosol]
HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Danio rerio)
GDP [cytosol]
MADD exchanges GTP for GDP on RAB27 (Danio rerio)
GDP [cytosol]
MON1:CCZ1 exchanges GTP for GDP on RAB7 (Danio rerio)
GDP [cytosol]
RAB13 GEFs exchange GTP for GDP on RAB13 (Danio rerio)
GDP [cytosol]
RAB21 GEFs exchange GTP for GDP on RAB21 (Danio rerio)
GDP [cytosol]
RAB3 GEFs exchange GTP for GDP on RAB3A (Danio rerio)
GDP [cytosol]
RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Danio rerio)
GDP [cytosol]
RAB5 GEFs exchange GTP for GDP on RAB5 (Danio rerio)
GDP [cytosol]
RAB8 GEFs exchange GTP for GDP on RAB8 (Danio rerio)
GDP [cytosol]
TRAPPC complexes exchange GTP for GDP on RAB1 (Danio rerio)
GDP [cytosol]
trans-Golgi Network Vesicle Budding (Danio rerio)
Golgi Associated Vesicle Biogenesis (Danio rerio)
trans-Golgi Network Vesicle Scission (Danio rerio)
GDP [cytosol]
Lysosome Vesicle Biogenesis (Danio rerio)
trans-Golgi Network Lysosomal Vesicle Scission (Danio rerio)
GDP [cytosol]
trans-Golgi Network Coat Activation (Danio rerio)
GDP [cytosol]
Cell Cycle (Dictyostelium discoideum)
Cell Cycle, Mitotic (Dictyostelium discoideum)
M Phase (Dictyostelium discoideum)
Mitotic Metaphase and Anaphase (Dictyostelium discoideum)
Mitotic Anaphase (Dictyostelium discoideum)
Nuclear Envelope (NE) Reassembly (Dictyostelium discoideum)
Postmitotic nuclear pore complex (NPC) reformation (Dictyostelium discoideum)
RCC1 stimulates GDP to GTP exchange on RAN (Dictyostelium discoideum)
GDP [cytosol]
Cellular responses to external stimuli (Dictyostelium discoideum)
Cellular responses to stress (Dictyostelium discoideum)
Cellular response to starvation (Dictyostelium discoideum)
Amino acids regulate mTORC1 (Dictyostelium discoideum)
RRAGA,B exchanges GDP for GTP (Dictyostelium discoideum)
GDP [cytosol]
RRAGC,D exchanges GTP for GDP (Dictyostelium discoideum)
GDP [cytosol]
Developmental Biology (Dictyostelium discoideum)
Nervous system development (Dictyostelium discoideum)
Axon guidance (Dictyostelium discoideum)
L1CAM interactions (Dictyostelium discoideum)
Recycling pathway of L1 (Dictyostelium discoideum)
Formation of clathrin coated vesicle (Dictyostelium discoideum)
GDP [cytosol]
Hemostasis (Dictyostelium discoideum)
Platelet activation, signaling and aggregation (Dictyostelium discoideum)
Platelet Aggregation (Plug Formation) (Dictyostelium discoideum)
Integrin signaling (Dictyostelium discoideum)
Activation of Rap1 by cytosolic GEFs (Dictyostelium discoideum)
GDP [cytosol]
Activation of Rap1 by membrane-associated GEFs (Dictyostelium discoideum)
GDP [cytosol]
Immune System (Dictyostelium discoideum)
Adaptive Immune System (Dictyostelium discoideum)
Rap1 signalling (Dictyostelium discoideum)
Activation of Rap1 by cytosolic GEFs (Dictyostelium discoideum)
GDP [cytosol]
Activation of Rap1 by membrane-associated GEFs (Dictyostelium discoideum)
GDP [cytosol]
Signaling by the B Cell Receptor (BCR) (Dictyostelium discoideum)
Downstream signaling events of B Cell Receptor (BCR) (Dictyostelium discoideum)
Activation of RAS in B cells (Dictyostelium discoideum)
p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Dictyostelium discoideum)
GDP [cytosol]
Metabolism (Dictyostelium discoideum)
Integration of energy metabolism (Dictyostelium discoideum)
Regulation of insulin secretion (Dictyostelium discoideum)
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Dictyostelium discoideum)
RAP1A exchanges GDP for GTP (Dictyostelium discoideum)
GDP [cytosol]
Metabolism of carbohydrates (Dictyostelium discoideum)
Glucose metabolism (Dictyostelium discoideum)
Gluconeogenesis (Dictyostelium discoideum)
oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Dictyostelium discoideum)
GDP [cytosol]
Metabolism of nucleotides (Dictyostelium discoideum)
Nucleobase biosynthesis (Dictyostelium discoideum)
Purine ribonucleoside monophosphate biosynthesis (Dictyostelium discoideum)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Dictyostelium discoideum)
GDP [cytosol]
Metabolism of proteins (Dictyostelium discoideum)
Post-translational protein modification (Dictyostelium discoideum)
Asparagine N-linked glycosylation (Dictyostelium discoideum)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Dictyostelium discoideum)
Addition of a second mannose to the N-glycan precursor by ALG2 (Dictyostelium discoideum)
GDP [cytosol]
Addition of the first mannose to the N-glycan precursor by ALG1 (Dictyostelium discoideum)
GDP [cytosol]
Synthesis of substrates in N-glycan biosythesis (Dictyostelium discoideum)
Synthesis of dolichyl-phosphate mannose (Dictyostelium discoideum)
dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Dictyostelium discoideum)
GDP [cytosol]
Transport to the Golgi and subsequent modification (Dictyostelium discoideum)
ER to Golgi Anterograde Transport (Dictyostelium discoideum)
COPII-mediated vesicle transport (Dictyostelium discoideum)
Nucleotide exchange on RAB1 (Dictyostelium discoideum)
GDP [cytosol]
SAR1 Activation And Membrane Binding (Dictyostelium discoideum)
GDP [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Dictyostelium discoideum)
Synthesis of dolichyl-phosphate mannose (Dictyostelium discoideum)
dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Dictyostelium discoideum)
GDP [cytosol]
Translation (Dictyostelium discoideum)
Eukaryotic Translation Initiation (Dictyostelium discoideum)
Cap-dependent Translation Initiation (Dictyostelium discoideum)
Recycling of eIF2:GDP (Dictyostelium discoideum)
eIF2 activation (Dictyostelium discoideum)
GDP [cytosol]
Signal Transduction (Dictyostelium discoideum)
Death Receptor Signalling (Dictyostelium discoideum)
p75 NTR receptor-mediated signalling (Dictyostelium discoideum)
Cell death signalling via NRAGE, NRIF and NADE (Dictyostelium discoideum)
NRAGE signals death through JNK (Dictyostelium discoideum)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Dictyostelium discoideum)
GDP [cytosol]
Integrin signaling (Dictyostelium discoideum)
Activation of Rap1 by cytosolic GEFs (Dictyostelium discoideum)
GDP [cytosol]
Activation of Rap1 by membrane-associated GEFs (Dictyostelium discoideum)
GDP [cytosol]
MAPK family signaling cascades (Dictyostelium discoideum)
MAPK1/MAPK3 signaling (Dictyostelium discoideum)
RAF/MAP kinase cascade (Dictyostelium discoideum)
Intrinsic nucleotide exchange on RAS (Dictyostelium discoideum)
GDP [cytosol]
RAS GEFs promote RAS nucleotide exchange (Dictyostelium discoideum)
GDP [cytosol]
RAS processing (Dictyostelium discoideum)
mature p21 RAS binds GDP (Dictyostelium discoideum)
GDP [cytosol]
MTOR signalling (Dictyostelium discoideum)
GTP loading by Rheb (Dictyostelium discoideum)
GDP [cytosol]
Signaling by GPCR (Dictyostelium discoideum)
GPCR downstream signalling (Dictyostelium discoideum)
G alpha (i) signalling events (Dictyostelium discoideum)
Liganded Gi-activating GPCR acts as a GEF for Gi (Dictyostelium discoideum)
GDP [cytosol]
Opioid Signalling (Dictyostelium discoideum)
G-protein activation (Dictyostelium discoideum)
G-protein alpha subunit is inactivated (Dictyostelium discoideum)
GDP [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Dictyostelium discoideum)
Signaling by Rho GTPases (Dictyostelium discoideum)
RHO GTPase cycle (Dictyostelium discoideum)
RAC1 GTPase cycle (Dictyostelium discoideum)
RAC1 GEFs activate RAC1 (Dictyostelium discoideum)
GDP [cytosol]
RAC2 GTPase cycle (Dictyostelium discoideum)
RAC2 GEFs activate RAC2 (Dictyostelium discoideum)
GDP [cytosol]
RAC3 GTPase cycle (Dictyostelium discoideum)
RAC3 GEFs activate RAC3 (Dictyostelium discoideum)
GDP [cytosol]
RHOU GTPase cycle (Dictyostelium discoideum)
RHOU auto-activates (Dictyostelium discoideum)
GDP [cytosol]
RHOV GTPase cycle (Dictyostelium discoideum)
RHOV binds GTP (Dictyostelium discoideum)
GDP [cytosol]
Vesicle-mediated transport (Dictyostelium discoideum)
Membrane Trafficking (Dictyostelium discoideum)
ER to Golgi Anterograde Transport (Dictyostelium discoideum)
COPII-mediated vesicle transport (Dictyostelium discoideum)
Nucleotide exchange on RAB1 (Dictyostelium discoideum)
GDP [cytosol]
SAR1 Activation And Membrane Binding (Dictyostelium discoideum)
GDP [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Dictyostelium discoideum)
Golgi-to-ER retrograde transport (Dictyostelium discoideum)
COPI-independent Golgi-to-ER retrograde traffic (Dictyostelium discoideum)
RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Dictyostelium discoideum)
GDP [cytosol]
Retrograde transport at the Trans-Golgi-Network (Dictyostelium discoideum)
RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Dictyostelium discoideum)
GDP [cytosol]
Rab regulation of trafficking (Dictyostelium discoideum)
RAB GEFs exchange GTP for GDP on RABs (Dictyostelium discoideum)
DENND6A,B exchange GTP for GDP on RAB14 (Dictyostelium discoideum)
GDP [cytosol]
HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Dictyostelium discoideum)
GDP [cytosol]
MON1:CCZ1 exchanges GTP for GDP on RAB7 (Dictyostelium discoideum)
GDP [cytosol]
RAB21 GEFs exchange GTP for GDP on RAB21 (Dictyostelium discoideum)
GDP [cytosol]
RAB31 GEFs exchange GTP for GDP on RAB31 (Dictyostelium discoideum)
GDP [cytosol]
RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Dictyostelium discoideum)
GDP [cytosol]
RAB5 GEFs exchange GTP for GDP on RAB5 (Dictyostelium discoideum)
GDP [cytosol]
RAB9 GEFs exchange GTP for GDP on RAB9 (Dictyostelium discoideum)
GDP [cytosol]
RIC1-RGP1 exchanges GTP for GDP on RAB6 (Dictyostelium discoideum)
GDP [cytosol]
TRAPPC complexes exchange GTP for GDP on RAB1 (Dictyostelium discoideum)
GDP [cytosol]
trans-Golgi Network Vesicle Budding (Dictyostelium discoideum)
Golgi Associated Vesicle Biogenesis (Dictyostelium discoideum)
trans-Golgi Network Vesicle Scission (Dictyostelium discoideum)
GDP [cytosol]
Lysosome Vesicle Biogenesis (Dictyostelium discoideum)
trans-Golgi Network Lysosomal Vesicle Scission (Dictyostelium discoideum)
GDP [cytosol]
trans-Golgi Network Coat Activation (Dictyostelium discoideum)
GDP [cytosol]
Cell Cycle (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
M Phase (Drosophila melanogaster)
Mitotic Metaphase and Anaphase (Drosophila melanogaster)
Mitotic Anaphase (Drosophila melanogaster)
Nuclear Envelope (NE) Reassembly (Drosophila melanogaster)
Postmitotic nuclear pore complex (NPC) reformation (Drosophila melanogaster)
RCC1 stimulates GDP to GTP exchange on RAN (Drosophila melanogaster)
GDP [cytosol]
Cellular responses to external stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to starvation (Drosophila melanogaster)
Amino acids regulate mTORC1 (Drosophila melanogaster)
RRAGA,B exchanges GDP for GTP (Drosophila melanogaster)
GDP [cytosol]
RRAGC,D exchanges GTP for GDP (Drosophila melanogaster)
GDP [cytosol]
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
EPH-Ephrin signaling (Drosophila melanogaster)
EPH-ephrin mediated repulsion of cells (Drosophila melanogaster)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)
GDP [cytosol]
VAV exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)
GDP [cytosol]
EPHA-mediated growth cone collapse (Drosophila melanogaster)
NGEF exchanges GTP for GDP on RHOA (Drosophila melanogaster)
GDP [cytosol]
EPHB-mediated forward signaling (Drosophila melanogaster)
p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)
GDP [cytosol]
p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Drosophila melanogaster)
GDP [cytosol]
L1CAM interactions (Drosophila melanogaster)
Recycling pathway of L1 (Drosophila melanogaster)
Formation of clathrin coated vesicle (Drosophila melanogaster)
GDP [cytosol]
Signal transduction by L1 (Drosophila melanogaster)
Activation of Rac1 by VAV2 (Drosophila melanogaster)
GDP [cytosol]
NCAM signaling for neurite out-growth (Drosophila melanogaster)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Drosophila melanogaster)
GDP [cytosol]
Semaphorin interactions (Drosophila melanogaster)
Sema4D in semaphorin signaling (Drosophila melanogaster)
Sema4D induced cell migration and growth-cone collapse (Drosophila melanogaster)
Activation of Rho by LARG and PDZ-RhoGEF (Drosophila melanogaster)
GDP [cytosol]
Drosophila signaling pathways (Drosophila melanogaster)
Insulin receptor mediated signaling (Drosophila melanogaster)
TOR signaling pathway (Drosophila melanogaster)
GDP is exchanged for GTP on DRheb (Drosophila melanogaster)
GDP [cytosol]
Planar Cell Polarity pathway (Drosophila melanogaster)
Activation of Downstream Effectors (Drosophila melanogaster)
RHO1 signalling (Drosophila melanogaster)
RHO1 GTPase cycle (Drosophila melanogaster)
RHOGEF2 stimulates nucleotide exchange of RHO1:GDP complex (Drosophila melanogaster)
GDP [cytosol]
Hemostasis (Drosophila melanogaster)
Cell surface interactions at the vascular wall (Drosophila melanogaster)
Tie2 Signaling (Drosophila melanogaster)
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Drosophila melanogaster)
GDP [cytosol]
Platelet activation, signaling and aggregation (Drosophila melanogaster)
GPVI-mediated activation cascade (Drosophila melanogaster)
VAV1 is a GEF for Rho/Rac family GTPases (Drosophila melanogaster)
GDP [cytosol]
VAV2 is a GEF for Rho/Rac family kinases (Drosophila melanogaster)
GDP [cytosol]
VAV3 is a GEF for Rho/Rac family kinases (Drosophila melanogaster)
GDP [cytosol]
Platelet Aggregation (Plug Formation) (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Activation of Rap1 by membrane-associated GEFs (Drosophila melanogaster)
GDP [cytosol]
Signal amplification (Drosophila melanogaster)
ADP signalling through P2Y purinoceptor 12 (Drosophila melanogaster)
Gi activation by P2Y purinoceptor 12 (Drosophila melanogaster)
GDP [cytosol]
Thromboxane signalling through TP receptor (Drosophila melanogaster)
G13 activation by TP receptor (Drosophila melanogaster)
GDP [cytosol]
Gq activation by TP receptor (Drosophila melanogaster)
GDP [cytosol]
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Rap1 signalling (Drosophila melanogaster)
Activation of Rap1 by membrane-associated GEFs (Drosophila melanogaster)
GDP [cytosol]
Cytokine Signaling in Immune system (Drosophila melanogaster)
FLT3 Signaling (Drosophila melanogaster)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Drosophila melanogaster)
GDP [cytosol]
Innate Immune System (Drosophila melanogaster)
DAP12 interactions (Drosophila melanogaster)
DAP12 signaling (Drosophila melanogaster)
SOS mediated nucleotide exchange of RAS (SHC) (Drosophila melanogaster)
GDP [cytosol]
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated MAPK activation (Drosophila melanogaster)
Activation of RAC1 by VAV (Drosophila melanogaster)
GDP [cytosol]
SOS mediated nucleotide exchange of RAS (SHC) (Drosophila melanogaster)
GDP [cytosol]
Metabolism (Drosophila melanogaster)
Integration of energy metabolism (Drosophila melanogaster)
Regulation of insulin secretion (Drosophila melanogaster)
Adrenaline,noradrenaline inhibits insulin secretion (Drosophila melanogaster)
Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Drosophila melanogaster)
GDP [cytosol]
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Drosophila melanogaster)
RAP1A exchanges GDP for GTP (Drosophila melanogaster)
GDP [cytosol]
Metabolism of carbohydrates (Drosophila melanogaster)
Glucose metabolism (Drosophila melanogaster)
Gluconeogenesis (Drosophila melanogaster)
oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Drosophila melanogaster)
GDP [cytosol]
Metabolism of nucleotides (Drosophila melanogaster)
Nucleobase biosynthesis (Drosophila melanogaster)
Purine ribonucleoside monophosphate biosynthesis (Drosophila melanogaster)
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Drosophila melanogaster)
GDP [cytosol]
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Asparagine N-linked glycosylation (Drosophila melanogaster)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Drosophila melanogaster)