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About
What is Reactome ?
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Zn2+ [cytosol]
Stable Identifier
R-ALL-29426
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
Zn++, zinc(2+), Zinc ion, Zn(II)
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Mycobacterium tuberculosis
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to external stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Detoxification of Reactive Oxygen Species (Bos taurus)
2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Bos taurus)
2xSOD1:CCS:Zn2+:2xCu1+ dimer [cytosol] (Bos taurus)
CCS:Zn2+:2xCu1+ dimer [cytosol] (Bos taurus)
CCS:Zn2+:2xCu1+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CCS:Zn2+:2xCu1+:SOD1:Zn2+ [cytosol] (Bos taurus)
CCS:Zn2+:2xCu1+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Bos taurus)
2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol] (Bos taurus)
2xHC-SOD1:Zn2+:Cu2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CCS:Zn2+:2xCu1+:SOD1:Zn2+ [cytosol] (Bos taurus)
CCS:Zn2+:2xCu1+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CCS:Zn2+:Cu1+ dimer [cytosol] (Bos taurus)
CCS:Zn2+:Cu1+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Bos taurus)
2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol] (Bos taurus)
2xHC-SOD1:Zn2+:Cu2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Bos taurus)
2xSOD1:CCS:Zn2+:2xCu1+ dimer [cytosol] (Bos taurus)
CCS:Zn2+:2xCu1+ dimer [cytosol] (Bos taurus)
CCS:Zn2+:2xCu1+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CCS:Zn2+:2xCu1+ dimer [cytosol] (Bos taurus)
CCS:Zn2+:2xCu1+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Response to metal ions (Bos taurus)
Metallothioneins bind metals (Bos taurus)
MT1A binds zinc (Bos taurus)
Zn2+ [cytosol]
MT1A:7Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
MT3 binds zinc (Bos taurus)
Zn2+ [cytosol]
MT3:7Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
MT3 exchanges zinc for copper (Bos taurus)
Zn2+ [cytosol]
MT3:4Zn2+:4Cu+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
MT3:7Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Downstream signaling events of B Cell Receptor (BCR) (Bos taurus)
Calcineurin activates NFAT (Bos taurus)
Calcineurin binds NFATC1,2,3 (Bos taurus)
Calcineurin (CaN) [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Calcineurin:Phosphorylated NFATC1,2,3 [cytosol] (Bos taurus)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Innate Immune System (Bos taurus)
Antimicrobial peptides (Bos taurus)
Ion influx/efflux at host-pathogen interface (Bos taurus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)
Divalent metals transported by NRAMP1 [cytosol]
Zn2+ [cytosol]
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
CLEC7A (Dectin-1) induces NFAT activation (Bos taurus)
Activation of Calcineurin (Bos taurus)
Calcineurin (CaN) [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Calcineurin binds and dephosphorylates NFAT (Bos taurus)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
NFAT:CaN:CaM [cytosol] (Bos taurus)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Translocation of CaN:CaM:NFAT to nucleus (Bos taurus)
NFAT:CaN:CaM [cytosol] (Bos taurus)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated Ca+2 mobilization (Bos taurus)
Activation of Calcineurin (Bos taurus)
Calcineurin (CaN) [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Calcineurin binds and dephosphorylates NFAT (Bos taurus)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
NFAT:CaN:CaM [cytosol] (Bos taurus)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Translocation of CaN:CaM:NFAT to nucleus (Bos taurus)
NFAT:CaN:CaM [cytosol] (Bos taurus)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
ROS and RNS production in phagocytes (Bos taurus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)
Divalent metals transported by NRAMP1 [cytosol]
Zn2+ [cytosol]
Metabolism (Bos taurus)
Abacavir transport and metabolism (Bos taurus)
Abacavir metabolism (Bos taurus)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Bos taurus)
ADH1A:2Zn2+ dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
Biological oxidations (Bos taurus)
Aflatoxin activation and detoxification (Bos taurus)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Bos taurus)
ACY1:Zn2+ dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
Phase I - Functionalization of compounds (Bos taurus)
Ethanol oxidation (Bos taurus)
ADH5 oxidises S-HMGSH to S-FGSH (Bos taurus)
ADH5:2xZn2+ dimer [cytosol] (Bos taurus)
ADH5:2xZn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Bos taurus)
alcohol dehydrogenase complex [cytosol] (Bos taurus)
ADH1A:2Zn2+ dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
ADH4:2Zn2+ dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
ADH7:2Zn2+ dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
alcohol dehydrogenase 1 (class I), alpha/beta dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
alcohol dehydrogenase 6 (class V) complex [cytosol] (Bos taurus)
Zn2+ [cytosol]
Metabolism of amino acids and derivatives (Bos taurus)
Amino acid synthesis and interconversion (transamination) (Bos taurus)
ASPA deacetylates NAA to acetate and L-aspartate (Bos taurus)
ASPA:Zn2+ dimer [cytosol] (Bos taurus)
ASPA:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Choline catabolism (Bos taurus)
BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Bos taurus)
BHMT:Zn2+ tetramer [cytosol] (Bos taurus)
BHMT:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Sulfur amino acid metabolism (Bos taurus)
BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Bos taurus)
BHMT:Zn2+ tetramer [cytosol] (Bos taurus)
BHMT:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Bos taurus)
BHMT2:Zn2+ tetramer [cytosol] (Bos taurus)
BHMT2:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Metabolism of carbohydrates (Bos taurus)
Formation of xylulose-5-phosphate (Bos taurus)
SORD tetramer oxidizes xylitol to D-xylulose (Bos taurus)
SORD tetramer [cytosol] (Bos taurus)
SORD:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Fructose metabolism (Bos taurus)
Fructose biosynthesis (Bos taurus)
SORD oxidizes D-sorbitol to Fru (Bos taurus)
SORD tetramer [cytosol] (Bos taurus)
SORD:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Lysosomal oligosaccharide catabolism (Bos taurus)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Bos taurus)
MAN2C1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Metabolism of lipids (Bos taurus)
Biosynthesis of specialized proresolving mediators (SPMs) (Bos taurus)
Biosynthesis of EPA-derived SPMs (Bos taurus)
Biosynthesis of E-series 18(S)-resolvins (Bos taurus)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Bos taurus)
LTA4H:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Fatty acid metabolism (Bos taurus)
Arachidonic acid metabolism (Bos taurus)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Bos taurus)
LTA4 is hydolysed to LTB4 by LTA4H (Bos taurus)
LTA4H:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
LTD4 is converted to LTE4 by DPEP1/2 (Bos taurus)
DPEP1,2,3 dimers [plasma membrane] (Bos taurus)
DPEP1 dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
DPEP2 dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
DPEP3 dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
Metabolism of nitric oxide: eNOS activation and regulation (Bos taurus)
NOSTRIN mediated eNOS trafficking (Bos taurus)
NOSTRIN mediated translocation of eNOS from plasma membrane (Bos taurus)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Bos taurus)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Bos taurus)
Zn2+ [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Bos taurus)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
Metabolism of nucleotides (Bos taurus)
Nucleobase catabolism (Bos taurus)
Purine catabolism (Bos taurus)
Guanine + H2O => Xanthine + NH4+ (Bos taurus)
GDA dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
Pyrimidine catabolism (Bos taurus)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Bos taurus)
DPYS tetramer [cytosol] (Bos taurus)
Zn2+ [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Bos taurus)
UPB1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Nucleotide salvage (Bos taurus)
Pyrimidine salvage (Bos taurus)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Bos taurus)
CDA tetramer [cytosol] (Bos taurus)
Zn2+ [cytosol]
Metabolism of porphyrins (Bos taurus)
Heme biosynthesis (Bos taurus)
ALAD binds to Pb2+ (Bos taurus)
Zn2+ [cytosol]
8x(ALAD:Zn2+) [cytosol] (Bos taurus)
Zn2+ [cytosol]
8xALAD:Pb2+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
ALAD condenses 2 dALAs to form PBG (Bos taurus)
8x(ALAD:Zn2+) [cytosol] (Bos taurus)
Zn2+ [cytosol]
Heme degradation (Bos taurus)
Biliverdin is reduced to bilirubin (Bos taurus)
Biliverdin reductase [cytosol] (Bos taurus)
Biliverdin reductase A:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of cofactors (Bos taurus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Bos taurus)
DHNTP is dephosphorylated by PTPS to PTHP (Bos taurus)
p-PTPS hexamer [cytosol] (Bos taurus)
Zn2+ [cytosol]
PTPS is phosphorylated by cGMP-dependant protein kinase II (Bos taurus)
p-PTPS hexamer [cytosol] (Bos taurus)
Zn2+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Molybdenum cofactor biosynthesis (Bos taurus)
NFS1 transfers sulfur from cysteine onto MOCS3 (Bos taurus)
MOCS3-S-S(1-):Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
MOCS3:Zn2+ (red.) [cytosol] (Bos taurus)
Zn2+ [cytosol]
Nicotinate metabolism (Bos taurus)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Bos taurus)
NADK:Zn2+ tetramer [cytosol] (Bos taurus)
Zn2+ [cytosol]
Vitamins B6 activation to pyridoxal phosphate (Bos taurus)
2xPDXK:2xZn2+ phosphorylates PXA (Bos taurus)
2xPDXK:2xZn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Reversible hydration of carbon dioxide (Bos taurus)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Bos taurus)
CA1,2,3,7,13:Zinc [cytosol] (Bos taurus)
CA13:Zinc [cytosol] (Bos taurus)
Zn2+ [cytosol]
CA1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CA3:Zinc [cytosol] (Bos taurus)
Zn2+ [cytosol]
CA7:Zinc [cytosol] (Bos taurus)
Zn2+ [cytosol]
The citric acid (TCA) cycle and respiratory electron transport (Bos taurus)
Pyruvate metabolism and Citric Acid (TCA) cycle (Bos taurus)
Pyruvate metabolism (Bos taurus)
GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Bos taurus)
GLO1 dimer:2xZn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Bos taurus)
HAGH-2:2xZn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Metabolism of proteins (Bos taurus)
Peptide hormone metabolism (Bos taurus)
Insulin processing (Bos taurus)
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Bos taurus)
Zn2+ [cytosol]
ZnT6 transports zinc into the golgi apparatus (Bos taurus)
Zn2+ [cytosol]
Signal Transduction (Bos taurus)
Signaling by Nuclear Receptors (Bos taurus)
Signaling by Retinoic Acid (Bos taurus)
RA biosynthesis pathway (Bos taurus)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Bos taurus)
ADH1A,1C,4 dimers [cytosol] (Bos taurus)
ADH1A:2Zn2+ dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
ADH4:2Zn2+ dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
alcohol dehydrogenase 1 (class I), alpha/beta dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
Signaling by WNT (Bos taurus)
Beta-catenin independent WNT signaling (Bos taurus)
Ca2+ pathway (Bos taurus)
Activation of Calcineurin (Bos taurus)
Calcineurin (CaN) [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Translocation of NFATC1:CaN:CaM to nucleus (Bos taurus)
NFATC1:CaN:CaM [cytosol] (Bos taurus)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Transport of small molecules (Bos taurus)
O2/CO2 exchange in erythrocytes (Bos taurus)
Erythrocytes take up carbon dioxide and release oxygen (Bos taurus)
Carbonic anhydrase I/II hydrates carbon dioxide (Bos taurus)
CA1,2 [cytosol] (Bos taurus)
CA1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
SLC-mediated transmembrane transport (Bos taurus)
Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
Metal ion SLC transporters (Bos taurus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)
Divalent metals transported by NRAMP1 [cytosol]
Zn2+ [cytosol]
Zinc transporters (Bos taurus)
Zinc efflux and compartmentalization by the SLC30 family (Bos taurus)
ZnT1 mediates the efflux of zinc from the cell (Bos taurus)
Zn2+ [cytosol]
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Bos taurus)
Zn2+ [cytosol]
ZnT6 transports zinc into the golgi apparatus (Bos taurus)
Zn2+ [cytosol]
Zinc influx into cells by the SLC39 gene family (Bos taurus)
SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Bos taurus)
Zn2+ [cytosol]
ZIP6 and ZIP14 mediate zinc influx into cells (Bos taurus)
Zn2+ [cytosol]
ZIP7 mediates zinc efflux from the endoplasmic reticulum (Bos taurus)
Zn2+ [cytosol]
ZIP8 mediates zinc influx into cells (Bos taurus)
Zn2+ [cytosol]
Cellular responses to external stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Detoxification of Reactive Oxygen Species (Caenorhabditis elegans)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Caenorhabditis elegans)
2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol] (Caenorhabditis elegans)
2xHC-SOD1:Zn2+:Cu2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Immune System (Caenorhabditis elegans)
Innate Immune System (Caenorhabditis elegans)
Antimicrobial peptides (Caenorhabditis elegans)
Ion influx/efflux at host-pathogen interface (Caenorhabditis elegans)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)
Divalent metals transported by NRAMP1 [cytosol]
Zn2+ [cytosol]
C-type lectin receptors (CLRs) (Caenorhabditis elegans)
CLEC7A (Dectin-1) signaling (Caenorhabditis elegans)
CLEC7A (Dectin-1) induces NFAT activation (Caenorhabditis elegans)
Activation of Calcineurin (Caenorhabditis elegans)
Calcineurin (CaN) [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Calmodulin [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Translocation of CaN:CaM:NFAT to nucleus (Caenorhabditis elegans)
NFAT:CaN:CaM [cytosol] (Caenorhabditis elegans)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Calmodulin [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Fc epsilon receptor (FCERI) signaling (Caenorhabditis elegans)
FCERI mediated Ca+2 mobilization (Caenorhabditis elegans)
Activation of Calcineurin (Caenorhabditis elegans)
Calcineurin (CaN) [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Calmodulin [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Translocation of CaN:CaM:NFAT to nucleus (Caenorhabditis elegans)
NFAT:CaN:CaM [cytosol] (Caenorhabditis elegans)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Calmodulin [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
ROS and RNS production in phagocytes (Caenorhabditis elegans)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)
Divalent metals transported by NRAMP1 [cytosol]
Zn2+ [cytosol]
Metabolism (Caenorhabditis elegans)
Abacavir transport and metabolism (Caenorhabditis elegans)
Abacavir metabolism (Caenorhabditis elegans)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Caenorhabditis elegans)
ADH1A:2Zn2+ dimer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Biological oxidations (Caenorhabditis elegans)
Aflatoxin activation and detoxification (Caenorhabditis elegans)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Caenorhabditis elegans)
ACY1:Zn2+ dimer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Phase I - Functionalization of compounds (Caenorhabditis elegans)
Ethanol oxidation (Caenorhabditis elegans)
ADH5 oxidises S-HMGSH to S-FGSH (Caenorhabditis elegans)
ADH5:2xZn2+ dimer [cytosol] (Caenorhabditis elegans)
ADH5:2xZn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Caenorhabditis elegans)
alcohol dehydrogenase complex [cytosol] (Caenorhabditis elegans)
ADH1A:2Zn2+ dimer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
ADH4:2Zn2+ dimer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
ADH7:2Zn2+ dimer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
alcohol dehydrogenase 1 (class I), alpha/beta dimer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
alcohol dehydrogenase 6 (class V) complex [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Phase II - Conjugation of compounds (Caenorhabditis elegans)
Methylation (Caenorhabditis elegans)
MTR transfers CH3 from MeCbl to HCYS (Caenorhabditis elegans)
MTRR:MTR(MeCbl) [cytosol] (Caenorhabditis elegans)
MTR:Zn2+:MeCbl [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
MTRR:MTR(cob(I)alamin) [cytosol] (Caenorhabditis elegans)
MTR:Zn2+:cob(I)alamin [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Sulfur amino acid metabolism (Caenorhabditis elegans)
MTR transfers CH3 from MeCbl to HCYS (Caenorhabditis elegans)
MTRR:MTR(MeCbl) [cytosol] (Caenorhabditis elegans)
MTR:Zn2+:MeCbl [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
MTRR:MTR(cob(I)alamin) [cytosol] (Caenorhabditis elegans)
MTR:Zn2+:cob(I)alamin [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Metabolism of carbohydrates (Caenorhabditis elegans)
Formation of xylulose-5-phosphate (Caenorhabditis elegans)
SORD tetramer oxidizes xylitol to D-xylulose (Caenorhabditis elegans)
SORD tetramer [cytosol] (Caenorhabditis elegans)
SORD:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Fructose metabolism (Caenorhabditis elegans)
Fructose biosynthesis (Caenorhabditis elegans)
SORD oxidizes D-sorbitol to Fru (Caenorhabditis elegans)
SORD tetramer [cytosol] (Caenorhabditis elegans)
SORD:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Metabolism of lipids (Caenorhabditis elegans)
Biosynthesis of specialized proresolving mediators (SPMs) (Caenorhabditis elegans)
Biosynthesis of EPA-derived SPMs (Caenorhabditis elegans)
Biosynthesis of E-series 18(S)-resolvins (Caenorhabditis elegans)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Caenorhabditis elegans)
LTA4H:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Fatty acid metabolism (Caenorhabditis elegans)
Arachidonic acid metabolism (Caenorhabditis elegans)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Caenorhabditis elegans)
LTA4 is hydolysed to LTB4 by LTA4H (Caenorhabditis elegans)
LTA4H:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Metabolism of nitric oxide: eNOS activation and regulation (Caenorhabditis elegans)
NOSTRIN mediated eNOS trafficking (Caenorhabditis elegans)
NOSTRIN mediated translocation of eNOS from plasma membrane (Caenorhabditis elegans)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Caenorhabditis elegans)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Caenorhabditis elegans)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Caenorhabditis elegans)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Caenorhabditis elegans)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Caenorhabditis elegans)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Caenorhabditis elegans)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
eNOS activation (Caenorhabditis elegans)
AKT1 phosphorylates eNOS (Caenorhabditis elegans)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
eNOS:CaM:HSP90 [plasma membrane] (Caenorhabditis elegans)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
Uncoupled eNOS favours the formation of superoxide (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
Metabolism of nucleotides (Caenorhabditis elegans)
Nucleobase catabolism (Caenorhabditis elegans)
Pyrimidine catabolism (Caenorhabditis elegans)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Caenorhabditis elegans)
DPYS tetramer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Caenorhabditis elegans)
UPB1:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Nucleotide salvage (Caenorhabditis elegans)
Purine salvage (Caenorhabditis elegans)
N6-methyl-AMP + H2O => IMP + methylamine (Caenorhabditis elegans)
ADAL:Zn [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Pyrimidine salvage (Caenorhabditis elegans)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Caenorhabditis elegans)
CDA tetramer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of cofactors (Caenorhabditis elegans)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Caenorhabditis elegans)
BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
DHNTP is dephosphorylated by PTPS to PTHP (Caenorhabditis elegans)
p-PTPS hexamer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
PTPS is phosphorylated by cGMP-dependant protein kinase II (Caenorhabditis elegans)
p-PTPS hexamer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Caenorhabditis elegans)
MTR transfers CH3 from MeCbl to HCYS (Caenorhabditis elegans)
MTRR:MTR(MeCbl) [cytosol] (Caenorhabditis elegans)
MTR:Zn2+:MeCbl [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
MTRR:MTR(cob(I)alamin) [cytosol] (Caenorhabditis elegans)
MTR:Zn2+:cob(I)alamin [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
MTR transfers CH3 group from MTHF to cob(I)alamin (Caenorhabditis elegans)
MTRR:MTR(MeCbl) [cytosol] (Caenorhabditis elegans)
MTR:Zn2+:MeCbl [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
MTRR:MTR(cob(I)alamin) [cytosol] (Caenorhabditis elegans)
MTR:Zn2+:cob(I)alamin [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
MTRR reduces cob(II)alamin to meCbl (Caenorhabditis elegans)
MTRR:MTR(MeCbl) [cytosol] (Caenorhabditis elegans)
MTR:Zn2+:MeCbl [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
MTRR:MTR(cob(II)alamin) [cytosol] (Caenorhabditis elegans)
MTRR:MTR [cytosol] (Caenorhabditis elegans)
MTR:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
cob(II)alamin binds to MTRR:MTR (Caenorhabditis elegans)
MTRR:MTR [cytosol] (Caenorhabditis elegans)
MTR:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
MTRR:MTR(cob(II)alamin) [cytosol] (Caenorhabditis elegans)
MTRR:MTR [cytosol] (Caenorhabditis elegans)
MTR:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Molybdenum cofactor biosynthesis (Caenorhabditis elegans)
NFS1 transfers sulfur from cysteine onto MOCS3 (Caenorhabditis elegans)
MOCS3-S-S(1-):Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
MOCS3:Zn2+ (red.) [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Vitamins B6 activation to pyridoxal phosphate (Caenorhabditis elegans)
2xPDXK:2xZn2+ phosphorylates PXA (Caenorhabditis elegans)
2xPDXK:2xZn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Reversible hydration of carbon dioxide (Caenorhabditis elegans)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Caenorhabditis elegans)
CA1,2,3,7,13:Zinc [cytosol] (Caenorhabditis elegans)
CA13:Zinc [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
CA1:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
CA7:Zinc [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
The citric acid (TCA) cycle and respiratory electron transport (Caenorhabditis elegans)
Pyruvate metabolism and Citric Acid (TCA) cycle (Caenorhabditis elegans)
Pyruvate metabolism (Caenorhabditis elegans)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Caenorhabditis elegans)
HAGH-2:2xZn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Metabolism of proteins (Caenorhabditis elegans)
Peptide hormone metabolism (Caenorhabditis elegans)
Insulin processing (Caenorhabditis elegans)
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Caenorhabditis elegans)
Zn2+ [cytosol]
ZnT6 transports zinc into the golgi apparatus (Caenorhabditis elegans)
Zn2+ [cytosol]
Signal Transduction (Caenorhabditis elegans)
Signaling by Nuclear Receptors (Caenorhabditis elegans)
ESR-mediated signaling (Caenorhabditis elegans)
Non-genomic estrogen signaling (Caenorhabditis elegans)
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
Signaling by Retinoic Acid (Caenorhabditis elegans)
RA biosynthesis pathway (Caenorhabditis elegans)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Caenorhabditis elegans)
ADH1A,1C,4 dimers [cytosol] (Caenorhabditis elegans)
ADH1A:2Zn2+ dimer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
ADH4:2Zn2+ dimer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
alcohol dehydrogenase 1 (class I), alpha/beta dimer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
VEGFR2 mediated vascular permeability (Caenorhabditis elegans)
AKT1 phosphorylates eNOS (Caenorhabditis elegans)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
eNOS:CaM:HSP90 [plasma membrane] (Caenorhabditis elegans)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
Signaling by WNT (Caenorhabditis elegans)
Beta-catenin independent WNT signaling (Caenorhabditis elegans)
Ca2+ pathway (Caenorhabditis elegans)
Activation of Calcineurin (Caenorhabditis elegans)
Calcineurin (CaN) [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Calmodulin [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Translocation of NFATC1:CaN:CaM to nucleus (Caenorhabditis elegans)
NFATC1:CaN:CaM [cytosol] (Caenorhabditis elegans)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Calmodulin [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Transport of small molecules (Caenorhabditis elegans)
O2/CO2 exchange in erythrocytes (Caenorhabditis elegans)
Erythrocytes take up carbon dioxide and release oxygen (Caenorhabditis elegans)
Carbonic anhydrase I/II hydrates carbon dioxide (Caenorhabditis elegans)
CA1,2 [cytosol] (Caenorhabditis elegans)
CA1:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of bile salts and organic acids, metal ions and amine compounds (Caenorhabditis elegans)
Metal ion SLC transporters (Caenorhabditis elegans)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)
Divalent metals transported by NRAMP1 [cytosol]
Zn2+ [cytosol]
Zinc transporters (Caenorhabditis elegans)
Zinc efflux and compartmentalization by the SLC30 family (Caenorhabditis elegans)
ZnT1 mediates the efflux of zinc from the cell (Caenorhabditis elegans)
Zn2+ [cytosol]
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Caenorhabditis elegans)
Zn2+ [cytosol]
ZnT6 transports zinc into the golgi apparatus (Caenorhabditis elegans)
Zn2+ [cytosol]
Zinc influx into cells by the SLC39 gene family (Caenorhabditis elegans)
SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Caenorhabditis elegans)
Zn2+ [cytosol]
ZIP6 and ZIP14 mediate zinc influx into cells (Caenorhabditis elegans)
Zn2+ [cytosol]
ZIP7 mediates zinc efflux from the endoplasmic reticulum (Caenorhabditis elegans)
Zn2+ [cytosol]
ZIP8 mediates zinc influx into cells (Caenorhabditis elegans)
Zn2+ [cytosol]
Cellular responses to external stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Detoxification of Reactive Oxygen Species (Canis familiaris)
2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Canis familiaris)
2xSOD1:CCS:Zn2+:2xCu1+ dimer [cytosol] (Canis familiaris)
CCS:Zn2+:2xCu1+ dimer [cytosol] (Canis familiaris)
CCS:Zn2+:2xCu1+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CCS:Zn2+:2xCu1+:SOD1:Zn2+ [cytosol] (Canis familiaris)
CCS:Zn2+:2xCu1+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Canis familiaris)
2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol] (Canis familiaris)
2xHC-SOD1:Zn2+:Cu2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CCS:Zn2+:2xCu1+:SOD1:Zn2+ [cytosol] (Canis familiaris)
CCS:Zn2+:2xCu1+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CCS:Zn2+:Cu1+ dimer [cytosol] (Canis familiaris)
CCS:Zn2+:Cu1+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Canis familiaris)
2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol] (Canis familiaris)
2xHC-SOD1:Zn2+:Cu2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Canis familiaris)
2xSOD1:CCS:Zn2+:2xCu1+ dimer [cytosol] (Canis familiaris)
CCS:Zn2+:2xCu1+ dimer [cytosol] (Canis familiaris)
CCS:Zn2+:2xCu1+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CCS:Zn2+:2xCu1+ dimer [cytosol] (Canis familiaris)
CCS:Zn2+:2xCu1+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Response to metal ions (Canis familiaris)
Metallothioneins bind metals (Canis familiaris)
MT1A binds zinc (Canis familiaris)
Zn2+ [cytosol]
MT1A:7Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MT3 binds zinc (Canis familiaris)
Zn2+ [cytosol]
MT3:7Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MT3 exchanges zinc for copper (Canis familiaris)
Zn2+ [cytosol]
MT3:4Zn2+:4Cu+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MT3:7Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
CLEC7A (Dectin-1) induces NFAT activation (Canis familiaris)
Translocation of CaN:CaM:NFAT to nucleus (Canis familiaris)
NFAT:CaN:CaM [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Translocation of CaN:CaM:NFAT to nucleus (Canis familiaris)
NFAT:CaN:CaM [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Metabolism (Canis familiaris)
Abacavir transport and metabolism (Canis familiaris)
Abacavir metabolism (Canis familiaris)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Canis familiaris)
ADH1A:2Zn2+ dimer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Biological oxidations (Canis familiaris)
Aflatoxin activation and detoxification (Canis familiaris)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Canis familiaris)
ACY1:Zn2+ dimer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Phase I - Functionalization of compounds (Canis familiaris)
Ethanol oxidation (Canis familiaris)
ADH5 oxidises S-HMGSH to S-FGSH (Canis familiaris)
ADH5:2xZn2+ dimer [cytosol] (Canis familiaris)
ADH5:2xZn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Canis familiaris)
alcohol dehydrogenase complex [cytosol] (Canis familiaris)
ADH1A:2Zn2+ dimer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
ADH4:2Zn2+ dimer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
alcohol dehydrogenase 1 (class I), alpha/beta dimer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Phase II - Conjugation of compounds (Canis familiaris)
Methylation (Canis familiaris)
MTR transfers CH3 from MeCbl to HCYS (Canis familiaris)
MTRR:MTR(MeCbl) [cytosol] (Canis familiaris)
MTR:Zn2+:MeCbl [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MTRR:MTR(cob(I)alamin) [cytosol] (Canis familiaris)
MTR:Zn2+:cob(I)alamin [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Metabolism of amino acids and derivatives (Canis familiaris)
Amino acid synthesis and interconversion (transamination) (Canis familiaris)
ASPA deacetylates NAA to acetate and L-aspartate (Canis familiaris)
ASPA:Zn2+ dimer [cytosol] (Canis familiaris)
ASPA:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Choline catabolism (Canis familiaris)
BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Canis familiaris)
BHMT:Zn2+ tetramer [cytosol] (Canis familiaris)
BHMT:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Sulfur amino acid metabolism (Canis familiaris)
BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Canis familiaris)
BHMT:Zn2+ tetramer [cytosol] (Canis familiaris)
BHMT:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Canis familiaris)
BHMT2:Zn2+ tetramer [cytosol] (Canis familiaris)
BHMT2:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MTR transfers CH3 from MeCbl to HCYS (Canis familiaris)
MTRR:MTR(MeCbl) [cytosol] (Canis familiaris)
MTR:Zn2+:MeCbl [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MTRR:MTR(cob(I)alamin) [cytosol] (Canis familiaris)
MTR:Zn2+:cob(I)alamin [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Metabolism of carbohydrates (Canis familiaris)
Formation of xylulose-5-phosphate (Canis familiaris)
SORD tetramer oxidizes xylitol to D-xylulose (Canis familiaris)
SORD tetramer [cytosol] (Canis familiaris)
SORD:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Fructose metabolism (Canis familiaris)
Fructose biosynthesis (Canis familiaris)
SORD oxidizes D-sorbitol to Fru (Canis familiaris)
SORD tetramer [cytosol] (Canis familiaris)
SORD:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Lysosomal oligosaccharide catabolism (Canis familiaris)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Canis familiaris)
MAN2C1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Metabolism of lipids (Canis familiaris)
Biosynthesis of specialized proresolving mediators (SPMs) (Canis familiaris)
Biosynthesis of EPA-derived SPMs (Canis familiaris)
Biosynthesis of E-series 18(S)-resolvins (Canis familiaris)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Canis familiaris)
LTA4H:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Fatty acid metabolism (Canis familiaris)
Arachidonic acid metabolism (Canis familiaris)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Canis familiaris)
LTA4 is hydolysed to LTB4 by LTA4H (Canis familiaris)
LTA4H:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
LTD4 is converted to LTE4 by DPEP1/2 (Canis familiaris)
DPEP1,2,3 dimers [plasma membrane] (Canis familiaris)
DPEP1 dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
DPEP2 dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
Metabolism of nitric oxide: eNOS activation and regulation (Canis familiaris)
NOSTRIN mediated eNOS trafficking (Canis familiaris)
NOSTRIN mediated translocation of eNOS from plasma membrane (Canis familiaris)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Canis familiaris)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Canis familiaris)
Zn2+ [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Canis familiaris)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
eNOS activation (Canis familiaris)
AKT1 phosphorylates eNOS (Canis familiaris)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
eNOS:CaM:HSP90 [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
BH2 binding can lead to eNOS uncoupling (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
Uncoupled eNOS favours the formation of superoxide (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
eNOS synthesizes NO (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
Metabolism of nucleotides (Canis familiaris)
Nucleobase catabolism (Canis familiaris)
Purine catabolism (Canis familiaris)
Guanine + H2O => Xanthine + NH4+ (Canis familiaris)
GDA dimer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Pyrimidine catabolism (Canis familiaris)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Canis familiaris)
DPYS tetramer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Canis familiaris)
UPB1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Nucleotide salvage (Canis familiaris)
Purine salvage (Canis familiaris)
N6-methyl-AMP + H2O => IMP + methylamine (Canis familiaris)
ADAL:Zn [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Pyrimidine salvage (Canis familiaris)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Canis familiaris)
CDA tetramer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Metabolism of porphyrins (Canis familiaris)
Heme biosynthesis (Canis familiaris)
ALAD binds to Pb2+ (Canis familiaris)
Zn2+ [cytosol]
8x(ALAD:Zn2+) [cytosol] (Canis familiaris)
Zn2+ [cytosol]
8xALAD:Pb2+:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
ALAD condenses 2 dALAs to form PBG (Canis familiaris)
8x(ALAD:Zn2+) [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Heme degradation (Canis familiaris)
Biliverdin is reduced to bilirubin (Canis familiaris)
Biliverdin reductase [cytosol] (Canis familiaris)
Biliverdin reductase A:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of cofactors (Canis familiaris)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Canis familiaris)
BH2 binding can lead to eNOS uncoupling (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
DHNTP is dephosphorylated by PTPS to PTHP (Canis familiaris)
p-PTPS hexamer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
PTPS is phosphorylated by cGMP-dependant protein kinase II (Canis familiaris)
p-PTPS hexamer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Canis familiaris)
MTR transfers CH3 from MeCbl to HCYS (Canis familiaris)
MTRR:MTR(MeCbl) [cytosol] (Canis familiaris)
MTR:Zn2+:MeCbl [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MTRR:MTR(cob(I)alamin) [cytosol] (Canis familiaris)
MTR:Zn2+:cob(I)alamin [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MTR transfers CH3 group from MTHF to cob(I)alamin (Canis familiaris)
MTRR:MTR(MeCbl) [cytosol] (Canis familiaris)
MTR:Zn2+:MeCbl [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MTRR:MTR(cob(I)alamin) [cytosol] (Canis familiaris)
MTR:Zn2+:cob(I)alamin [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MTRR reduces cob(II)alamin to meCbl (Canis familiaris)
MTRR:MTR(MeCbl) [cytosol] (Canis familiaris)
MTR:Zn2+:MeCbl [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MTRR:MTR(cob(II)alamin) [cytosol] (Canis familiaris)
MTRR:MTR [cytosol] (Canis familiaris)
MTR:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
cob(II)alamin binds to MTRR:MTR (Canis familiaris)
MTRR:MTR [cytosol] (Canis familiaris)
MTR:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MTRR:MTR(cob(II)alamin) [cytosol] (Canis familiaris)
MTRR:MTR [cytosol] (Canis familiaris)
MTR:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Molybdenum cofactor biosynthesis (Canis familiaris)
NFS1 transfers sulfur from cysteine onto MOCS3 (Canis familiaris)
MOCS3-S-S(1-):Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MOCS3:Zn2+ (red.) [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Nicotinate metabolism (Canis familiaris)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Canis familiaris)
NADK:Zn2+ tetramer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Vitamins B6 activation to pyridoxal phosphate (Canis familiaris)
2xPDXK:2xZn2+ phosphorylates PXA (Canis familiaris)
2xPDXK:2xZn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Reversible hydration of carbon dioxide (Canis familiaris)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Canis familiaris)
CA1,2,3,7,13:Zinc [cytosol] (Canis familiaris)
CA13:Zinc [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CA1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CA3:Zinc [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CA7:Zinc [cytosol] (Canis familiaris)
Zn2+ [cytosol]
The citric acid (TCA) cycle and respiratory electron transport (Canis familiaris)
Pyruvate metabolism and Citric Acid (TCA) cycle (Canis familiaris)
Pyruvate metabolism (Canis familiaris)
GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Canis familiaris)
GLO1 dimer:2xZn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Canis familiaris)
HAGH-2:2xZn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Metabolism of proteins (Canis familiaris)
Peptide hormone metabolism (Canis familiaris)
Insulin processing (Canis familiaris)
SLC30A8 transports Zn2+ from cytosol to secretory granule (Canis familiaris)
Zn2+ [cytosol]
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Canis familiaris)
Zn2+ [cytosol]
ZnT6 transports zinc into the golgi apparatus (Canis familiaris)
Zn2+ [cytosol]
Metabolism of Angiotensinogen to Angiotensins (Canis familiaris)
AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Canis familiaris)
AOPEP:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Signal Transduction (Canis familiaris)
Signaling by Nuclear Receptors (Canis familiaris)
ESR-mediated signaling (Canis familiaris)
Non-genomic estrogen signaling (Canis familiaris)
eNOS synthesizes NO (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
Signaling by Retinoic Acid (Canis familiaris)
RA biosynthesis pathway (Canis familiaris)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Canis familiaris)
alcohol dehydrogenase complex [cytosol] (Canis familiaris)
ADH1A:2Zn2+ dimer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
ADH4:2Zn2+ dimer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
alcohol dehydrogenase 1 (class I), alpha/beta dimer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
VEGFR2 mediated vascular permeability (Canis familiaris)
AKT1 phosphorylates eNOS (Canis familiaris)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
eNOS:CaM:HSP90 [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
eNOS synthesizes NO (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
Signaling by WNT (Canis familiaris)
Beta-catenin independent WNT signaling (Canis familiaris)
Ca2+ pathway (Canis familiaris)
Translocation of NFATC1:CaN:CaM to nucleus (Canis familiaris)
NFATC1:CaN:CaM [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Transport of small molecules (Canis familiaris)
O2/CO2 exchange in erythrocytes (Canis familiaris)
Erythrocytes take up carbon dioxide and release oxygen (Canis familiaris)
Carbonic anhydrase I/II hydrates carbon dioxide (Canis familiaris)
CA1,2 [cytosol] (Canis familiaris)
CA1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
SLC-mediated transmembrane transport (Canis familiaris)
Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
Metal ion SLC transporters (Canis familiaris)
Zinc transporters (Canis familiaris)
Zinc efflux and compartmentalization by the SLC30 family (Canis familiaris)
SLC30A8 transports Zn2+ from cytosol to secretory granule (Canis familiaris)
Zn2+ [cytosol]
ZnT1 mediates the efflux of zinc from the cell (Canis familiaris)
Zn2+ [cytosol]
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Canis familiaris)
Zn2+ [cytosol]
ZnT6 transports zinc into the golgi apparatus (Canis familiaris)
Zn2+ [cytosol]
Zinc influx into cells by the SLC39 gene family (Canis familiaris)
SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Canis familiaris)
Zn2+ [cytosol]
ZIP6 and ZIP14 mediate zinc influx into cells (Canis familiaris)
Zn2+ [cytosol]
ZIP8 mediates zinc influx into cells (Canis familiaris)
Zn2+ [cytosol]
Cellular responses to external stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Detoxification of Reactive Oxygen Species (Danio rerio)
2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Danio rerio)
2xSOD1:CCS:Zn2+:2xCu1+ dimer [cytosol] (Danio rerio)
CCS:Zn2+:2xCu1+ dimer [cytosol] (Danio rerio)
CCS:Zn2+:2xCu1+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
CCS:Zn2+:2xCu1+:SOD1:Zn2+ [cytosol] (Danio rerio)
CCS:Zn2+:2xCu1+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Danio rerio)
2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol] (Danio rerio)
2xHC-SOD1:Zn2+:Cu2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
CCS:Zn2+:2xCu1+:SOD1:Zn2+ [cytosol] (Danio rerio)
CCS:Zn2+:2xCu1+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
CCS:Zn2+:Cu1+ dimer [cytosol] (Danio rerio)
CCS:Zn2+:Cu1+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Danio rerio)
2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol] (Danio rerio)
2xHC-SOD1:Zn2+:Cu2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Danio rerio)
2xSOD1:CCS:Zn2+:2xCu1+ dimer [cytosol] (Danio rerio)
CCS:Zn2+:2xCu1+ dimer [cytosol] (Danio rerio)
CCS:Zn2+:2xCu1+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
CCS:Zn2+:2xCu1+ dimer [cytosol] (Danio rerio)
CCS:Zn2+:2xCu1+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Response to metal ions (Danio rerio)
Metallothioneins bind metals (Danio rerio)
MT3 exchanges zinc for copper (Danio rerio)
Zn2+ [cytosol]
MT3:4Zn2+:4Cu+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
MT3:7Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Immune System (Danio rerio)
Innate Immune System (Danio rerio)
Antimicrobial peptides (Danio rerio)
Ion influx/efflux at host-pathogen interface (Danio rerio)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Danio rerio)
Divalent metals transported by NRAMP1 [cytosol]
Zn2+ [cytosol]
C-type lectin receptors (CLRs) (Danio rerio)
CLEC7A (Dectin-1) signaling (Danio rerio)
CLEC7A (Dectin-1) induces NFAT activation (Danio rerio)
Translocation of CaN:CaM:NFAT to nucleus (Danio rerio)
NFAT:CaN:CaM [cytosol] (Danio rerio)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Danio rerio)
PPP3CA,B:Calmodulin [cytosol] (Danio rerio)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Fc epsilon receptor (FCERI) signaling (Danio rerio)
FCERI mediated Ca+2 mobilization (Danio rerio)
Translocation of CaN:CaM:NFAT to nucleus (Danio rerio)
NFAT:CaN:CaM [cytosol] (Danio rerio)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Danio rerio)
PPP3CA,B:Calmodulin [cytosol] (Danio rerio)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
ROS and RNS production in phagocytes (Danio rerio)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Danio rerio)
Divalent metals transported by NRAMP1 [cytosol]
Zn2+ [cytosol]
Metabolism (Danio rerio)
Abacavir transport and metabolism (Danio rerio)
Abacavir metabolism (Danio rerio)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Danio rerio)
ADH1A:2Zn2+ dimer [cytosol] (Danio rerio)
Zn2+ [cytosol]
Biological oxidations (Danio rerio)
Aflatoxin activation and detoxification (Danio rerio)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Danio rerio)
ACY1:Zn2+ dimer [cytosol] (Danio rerio)
Zn2+ [cytosol]
ACY3:Zn2+ dimer hydrolyses mercapturic acids (Danio rerio)
ACY3:Zn2+ dimer [cytosol] (Danio rerio)
Zn2+ [cytosol]
Phase I - Functionalization of compounds (Danio rerio)
Ethanol oxidation (Danio rerio)
ADH5 oxidises S-HMGSH to S-FGSH (Danio rerio)
ADH5:2xZn2+ dimer [cytosol] (Danio rerio)
ADH5:2xZn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Danio rerio)
alcohol dehydrogenase complex [cytosol] (Danio rerio)
ADH1A:2Zn2+ dimer [cytosol] (Danio rerio)
Zn2+ [cytosol]
ADH4:2Zn2+ dimer [cytosol] (Danio rerio)
Zn2+ [cytosol]
ADH7:2Zn2+ dimer [cytosol] (Danio rerio)
Zn2+ [cytosol]
alcohol dehydrogenase 1 (class I), alpha/beta dimer [cytosol] (Danio rerio)
Zn2+ [cytosol]
alcohol dehydrogenase 6 (class V) complex [cytosol] (Danio rerio)
Zn2+ [cytosol]
Phase II - Conjugation of compounds (Danio rerio)
Methylation (Danio rerio)
MTR transfers CH3 from MeCbl to HCYS (Danio rerio)
MTRR:MTR(MeCbl) [cytosol] (Danio rerio)
MTR:Zn2+:MeCbl [cytosol] (Danio rerio)
Zn2+ [cytosol]
MTRR:MTR(cob(I)alamin) [cytosol] (Danio rerio)
MTR:Zn2+:cob(I)alamin [cytosol] (Danio rerio)
Zn2+ [cytosol]
Metabolism of amino acids and derivatives (Danio rerio)
Amino acid synthesis and interconversion (transamination) (Danio rerio)
ASPA deacetylates NAA to acetate and L-aspartate (Danio rerio)
ASPA:Zn2+ dimer [cytosol] (Danio rerio)
ASPA:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Choline catabolism (Danio rerio)
BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Danio rerio)
BHMT:Zn2+ tetramer [cytosol] (Danio rerio)
BHMT:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Sulfur amino acid metabolism (Danio rerio)
BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Danio rerio)
BHMT:Zn2+ tetramer [cytosol] (Danio rerio)
BHMT:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Danio rerio)
BHMT2:Zn2+ tetramer [cytosol] (Danio rerio)
BHMT2:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
MTR transfers CH3 from MeCbl to HCYS (Danio rerio)
MTRR:MTR(MeCbl) [cytosol] (Danio rerio)
MTR:Zn2+:MeCbl [cytosol] (Danio rerio)
Zn2+ [cytosol]
MTRR:MTR(cob(I)alamin) [cytosol] (Danio rerio)
MTR:Zn2+:cob(I)alamin [cytosol] (Danio rerio)
Zn2+ [cytosol]
Metabolism of carbohydrates (Danio rerio)
Formation of xylulose-5-phosphate (Danio rerio)
SORD tetramer oxidizes xylitol to D-xylulose (Danio rerio)
SORD tetramer [cytosol] (Danio rerio)
SORD:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Fructose metabolism (Danio rerio)
Fructose biosynthesis (Danio rerio)
SORD oxidizes D-sorbitol to Fru (Danio rerio)
SORD tetramer [cytosol] (Danio rerio)
SORD:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Lysosomal oligosaccharide catabolism (Danio rerio)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Danio rerio)
MAN2C1:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Metabolism of lipids (Danio rerio)
Biosynthesis of specialized proresolving mediators (SPMs) (Danio rerio)
Biosynthesis of EPA-derived SPMs (Danio rerio)
Biosynthesis of E-series 18(S)-resolvins (Danio rerio)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Danio rerio)
LTA4H:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Fatty acid metabolism (Danio rerio)
Arachidonic acid metabolism (Danio rerio)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Danio rerio)
LTA4 is hydolysed to LTB4 by LTA4H (Danio rerio)
LTA4H:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
LTD4 is converted to LTE4 by DPEP1/2 (Danio rerio)
DPEP1,2,3 dimers [plasma membrane] (Danio rerio)
DPEP1 dimer [plasma membrane] (Danio rerio)
Zn2+ [cytosol]
DPEP2 dimer [plasma membrane] (Danio rerio)
Zn2+ [cytosol]
DPEP3 dimer [plasma membrane] (Danio rerio)
Zn2+ [cytosol]
Metabolism of nitric oxide: eNOS activation and regulation (Danio rerio)
NOSTRIN mediated eNOS trafficking (Danio rerio)
NOSTRIN mediated translocation of eNOS from plasma membrane (Danio rerio)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Danio rerio)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Danio rerio)
Zn2+ [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Danio rerio)
Zn2+ [cytosol]
Metabolism of nucleotides (Danio rerio)
Nucleobase catabolism (Danio rerio)
Purine catabolism (Danio rerio)
Guanine + H2O => Xanthine + NH4+ (Danio rerio)
GDA dimer [cytosol] (Danio rerio)
Zn2+ [cytosol]
Pyrimidine catabolism (Danio rerio)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Danio rerio)
DPYS tetramer [cytosol] (Danio rerio)
Zn2+ [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Danio rerio)
UPB1:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Nucleotide salvage (Danio rerio)
Purine salvage (Danio rerio)
N6-methyl-AMP + H2O => IMP + methylamine (Danio rerio)
ADAL:Zn [cytosol] (Danio rerio)
Zn2+ [cytosol]
Pyrimidine salvage (Danio rerio)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Danio rerio)
CDA tetramer [cytosol] (Danio rerio)
Zn2+ [cytosol]
Metabolism of porphyrins (Danio rerio)
Heme biosynthesis (Danio rerio)
ALAD binds to Pb2+ (Danio rerio)
Zn2+ [cytosol]
8x(ALAD:Zn2+) [cytosol] (Danio rerio)
Zn2+ [cytosol]
8xALAD:Pb2+:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
ALAD condenses 2 dALAs to form PBG (Danio rerio)
8x(ALAD:Zn2+) [cytosol] (Danio rerio)
Zn2+ [cytosol]
Heme degradation (Danio rerio)
Biliverdin is reduced to bilirubin (Danio rerio)
Biliverdin reductase [cytosol] (Danio rerio)
Biliverdin reductase A:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of cofactors (Danio rerio)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Danio rerio)
DHNTP is dephosphorylated by PTPS to PTHP (Danio rerio)
p-PTPS hexamer [cytosol] (Danio rerio)
Zn2+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Danio rerio)
MTR transfers CH3 from MeCbl to HCYS (Danio rerio)
MTRR:MTR(MeCbl) [cytosol] (Danio rerio)
MTR:Zn2+:MeCbl [cytosol] (Danio rerio)
Zn2+ [cytosol]
MTRR:MTR(cob(I)alamin) [cytosol] (Danio rerio)
MTR:Zn2+:cob(I)alamin [cytosol] (Danio rerio)
Zn2+ [cytosol]
MTR transfers CH3 group from MTHF to cob(I)alamin (Danio rerio)
MTRR:MTR(MeCbl) [cytosol] (Danio rerio)
MTR:Zn2+:MeCbl [cytosol] (Danio rerio)
Zn2+ [cytosol]
MTRR:MTR(cob(I)alamin) [cytosol] (Danio rerio)
MTR:Zn2+:cob(I)alamin [cytosol] (Danio rerio)
Zn2+ [cytosol]
MTRR reduces cob(II)alamin to meCbl (Danio rerio)
MTRR:MTR(MeCbl) [cytosol] (Danio rerio)
MTR:Zn2+:MeCbl [cytosol] (Danio rerio)
Zn2+ [cytosol]
MTRR:MTR(cob(II)alamin) [cytosol] (Danio rerio)
MTRR:MTR [cytosol] (Danio rerio)
MTR:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
cob(II)alamin binds to MTRR:MTR (Danio rerio)
MTRR:MTR [cytosol] (Danio rerio)
MTR:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
MTRR:MTR(cob(II)alamin) [cytosol] (Danio rerio)
MTRR:MTR [cytosol] (Danio rerio)
MTR:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Molybdenum cofactor biosynthesis (Danio rerio)
NFS1 transfers sulfur from cysteine onto MOCS3 (Danio rerio)
MOCS3-S-S(1-):Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
MOCS3:Zn2+ (red.) [cytosol] (Danio rerio)
Zn2+ [cytosol]
Nicotinate metabolism (Danio rerio)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Danio rerio)
NADK:Zn2+ tetramer [cytosol] (Danio rerio)
Zn2+ [cytosol]
Vitamins B6 activation to pyridoxal phosphate (Danio rerio)
2xPDXK:2xZn2+ phosphorylates PXA (Danio rerio)
2xPDXK:2xZn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Reversible hydration of carbon dioxide (Danio rerio)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Danio rerio)
CA1,2,3,7,13:Zinc [cytosol] (Danio rerio)
CA13:Zinc [cytosol] (Danio rerio)
Zn2+ [cytosol]
CA1:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
CA7:Zinc [cytosol] (Danio rerio)
Zn2+ [cytosol]
The citric acid (TCA) cycle and respiratory electron transport (Danio rerio)
Pyruvate metabolism and Citric Acid (TCA) cycle (Danio rerio)
Pyruvate metabolism (Danio rerio)
GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Danio rerio)
GLO1 dimer:2xZn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Danio rerio)
HAGH-2:2xZn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Metabolism of proteins (Danio rerio)
Peptide hormone metabolism (Danio rerio)
Insulin processing (Danio rerio)
SLC30A8 transports Zn2+ from cytosol to secretory granule (Danio rerio)
Zn2+ [cytosol]
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Danio rerio)
Zn2+ [cytosol]
ZnT6 transports zinc into the golgi apparatus (Danio rerio)
Zn2+ [cytosol]
Metabolism of Angiotensinogen to Angiotensins (Danio rerio)
AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41) (Danio rerio)
AOPEP:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Signal Transduction (Danio rerio)
Signaling by Nuclear Receptors (Danio rerio)
Signaling by Retinoic Acid (Danio rerio)
RA biosynthesis pathway (Danio rerio)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Danio rerio)
ADH1A,1C,4 dimers [cytosol] (Danio rerio)
ADH1A:2Zn2+ dimer [cytosol] (Danio rerio)
Zn2+ [cytosol]
ADH4:2Zn2+ dimer [cytosol] (Danio rerio)
Zn2+ [cytosol]
alcohol dehydrogenase 1 (class I), alpha/beta dimer [cytosol] (Danio rerio)
Zn2+ [cytosol]
Signaling by WNT (Danio rerio)
Beta-catenin independent WNT signaling (Danio rerio)
Ca2+ pathway (Danio rerio)
Translocation of NFATC1:CaN:CaM to nucleus (Danio rerio)
NFATC1:CaN:CaM [cytosol] (Danio rerio)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Danio rerio)
PPP3CA,B:Calmodulin [cytosol] (Danio rerio)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Transport of small molecules (Danio rerio)
O2/CO2 exchange in erythrocytes (Danio rerio)
Erythrocytes take up carbon dioxide and release oxygen (Danio rerio)
Carbonic anhydrase I/II hydrates carbon dioxide (Danio rerio)
CA1,2 [cytosol] (Danio rerio)
CA1:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
SLC-mediated transmembrane transport (Danio rerio)
Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
Metal ion SLC transporters (Danio rerio)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Danio rerio)
Divalent metals transported by NRAMP1 [cytosol]
Zn2+ [cytosol]
Zinc transporters (Danio rerio)
Zinc efflux and compartmentalization by the SLC30 family (Danio rerio)
SLC30A8 transports Zn2+ from cytosol to secretory granule (Danio rerio)
Zn2+ [cytosol]
ZnT1 mediates the efflux of zinc from the cell (Danio rerio)
Zn2+ [cytosol]
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Danio rerio)
Zn2+ [cytosol]
ZnT6 transports zinc into the golgi apparatus (Danio rerio)
Zn2+ [cytosol]
Zinc influx into cells by the SLC39 gene family (Danio rerio)
SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Danio rerio)
Zn2+ [cytosol]
ZIP6 and ZIP14 mediate zinc influx into cells (Danio rerio)
Zn2+ [cytosol]
ZIP7 mediates zinc efflux from the endoplasmic reticulum (Danio rerio)
Zn2+ [cytosol]
ZIP8 mediates zinc influx into cells (Danio rerio)
Zn2+ [cytosol]
Cellular responses to external stimuli (Dictyostelium discoideum)
Cellular responses to stress (Dictyostelium discoideum)
Detoxification of Reactive Oxygen Species (Dictyostelium discoideum)
2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Dictyostelium discoideum)
2xSOD1:CCS:Zn2+:2xCu1+ dimer [cytosol] (Dictyostelium discoideum)
CCS:Zn2+:2xCu1+ dimer [cytosol] (Dictyostelium discoideum)
CCS:Zn2+:2xCu1+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
CCS:Zn2+:2xCu1+:SOD1:Zn2+ [cytosol] (Dictyostelium discoideum)
CCS:Zn2+:2xCu1+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Dictyostelium discoideum)
2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol] (Dictyostelium discoideum)
2xHC-SOD1:Zn2+:Cu2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
CCS:Zn2+:2xCu1+:SOD1:Zn2+ [cytosol] (Dictyostelium discoideum)
CCS:Zn2+:2xCu1+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
CCS:Zn2+:Cu1+ dimer [cytosol] (Dictyostelium discoideum)
CCS:Zn2+:Cu1+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Dictyostelium discoideum)
2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol] (Dictyostelium discoideum)
2xHC-SOD1:Zn2+:Cu2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Dictyostelium discoideum)
2xSOD1:CCS:Zn2+:2xCu1+ dimer [cytosol] (Dictyostelium discoideum)
CCS:Zn2+:2xCu1+ dimer [cytosol] (Dictyostelium discoideum)
CCS:Zn2+:2xCu1+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
CCS:Zn2+:2xCu1+ dimer [cytosol] (Dictyostelium discoideum)
CCS:Zn2+:2xCu1+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Immune System (Dictyostelium discoideum)
Innate Immune System (Dictyostelium discoideum)
Antimicrobial peptides (Dictyostelium discoideum)
Ion influx/efflux at host-pathogen interface (Dictyostelium discoideum)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Dictyostelium discoideum)
Divalent metals transported by NRAMP1 [cytosol]
Zn2+ [cytosol]
C-type lectin receptors (CLRs) (Dictyostelium discoideum)
CLEC7A (Dectin-1) signaling (Dictyostelium discoideum)
CLEC7A (Dectin-1) induces NFAT activation (Dictyostelium discoideum)
Activation of Calcineurin (Dictyostelium discoideum)
Calcineurin (CaN) [cytosol] (Dictyostelium discoideum)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Dictyostelium discoideum)
PPP3CA,B:Calmodulin [cytosol] (Dictyostelium discoideum)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Translocation of CaN:CaM:NFAT to nucleus (Dictyostelium discoideum)
NFAT:CaN:CaM [cytosol] (Dictyostelium discoideum)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Dictyostelium discoideum)
PPP3CA,B:Calmodulin [cytosol] (Dictyostelium discoideum)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Fc epsilon receptor (FCERI) signaling (Dictyostelium discoideum)
FCERI mediated Ca+2 mobilization (Dictyostelium discoideum)
Activation of Calcineurin (Dictyostelium discoideum)
Calcineurin (CaN) [cytosol] (Dictyostelium discoideum)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Dictyostelium discoideum)
PPP3CA,B:Calmodulin [cytosol] (Dictyostelium discoideum)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Translocation of CaN:CaM:NFAT to nucleus (Dictyostelium discoideum)
NFAT:CaN:CaM [cytosol] (Dictyostelium discoideum)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Dictyostelium discoideum)
PPP3CA,B:Calmodulin [cytosol] (Dictyostelium discoideum)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
ROS and RNS production in phagocytes (Dictyostelium discoideum)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Dictyostelium discoideum)
Divalent metals transported by NRAMP1 [cytosol]
Zn2+ [cytosol]
Metabolism (Dictyostelium discoideum)
Abacavir transport and metabolism (Dictyostelium discoideum)
Abacavir metabolism (Dictyostelium discoideum)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Dictyostelium discoideum)
ADH1A:2Zn2+ dimer [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Biological oxidations (Dictyostelium discoideum)
Aflatoxin activation and detoxification (Dictyostelium discoideum)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Dictyostelium discoideum)
ACY1:Zn2+ dimer [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Phase I - Functionalization of compounds (Dictyostelium discoideum)
Ethanol oxidation (Dictyostelium discoideum)
ADH5 oxidises S-HMGSH to S-FGSH (Dictyostelium discoideum)
ADH5:2xZn2+ dimer [cytosol] (Dictyostelium discoideum)
ADH5:2xZn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Dictyostelium discoideum)
alcohol dehydrogenase complex [cytosol] (Dictyostelium discoideum)
ADH1A:2Zn2+ dimer [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
ADH4:2Zn2+ dimer [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
ADH7:2Zn2+ dimer [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
alcohol dehydrogenase 1 (class I), alpha/beta dimer [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
alcohol dehydrogenase 6 (class V) complex [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Phase II - Conjugation of compounds (Dictyostelium discoideum)
Methylation (Dictyostelium discoideum)
MTR transfers CH3 from MeCbl to HCYS (Dictyostelium discoideum)
MTRR:MTR(MeCbl) [cytosol] (Dictyostelium discoideum)
MTR:Zn2+:MeCbl [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
MTRR:MTR(cob(I)alamin) [cytosol] (Dictyostelium discoideum)
MTR:Zn2+:cob(I)alamin [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Sulfur amino acid metabolism (Dictyostelium discoideum)
MTR transfers CH3 from MeCbl to HCYS (Dictyostelium discoideum)
MTRR:MTR(MeCbl) [cytosol] (Dictyostelium discoideum)
MTR:Zn2+:MeCbl [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
MTRR:MTR(cob(I)alamin) [cytosol] (Dictyostelium discoideum)
MTR:Zn2+:cob(I)alamin [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Metabolism of carbohydrates (Dictyostelium discoideum)
Lysosomal oligosaccharide catabolism (Dictyostelium discoideum)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Dictyostelium discoideum)
MAN2C1:Zn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Metabolism of lipids (Dictyostelium discoideum)
Biosynthesis of specialized proresolving mediators (SPMs) (Dictyostelium discoideum)
Biosynthesis of EPA-derived SPMs (Dictyostelium discoideum)
Biosynthesis of E-series 18(S)-resolvins (Dictyostelium discoideum)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Dictyostelium discoideum)
LTA4H:Zn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Fatty acid metabolism (Dictyostelium discoideum)
Arachidonic acid metabolism (Dictyostelium discoideum)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Dictyostelium discoideum)
LTA4 is hydolysed to LTB4 by LTA4H (Dictyostelium discoideum)
LTA4H:Zn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Metabolism of nitric oxide: eNOS activation and regulation (Dictyostelium discoideum)
NOSIP mediated eNOS trafficking (Dictyostelium discoideum)
eNOS binds NOSIP (Dictyostelium discoideum)
eNOS:NOSIP [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Dictyostelium discoideum)
eNOS:NOSIP [Golgi membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
eNOS:NOSIP [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
NOSTRIN mediated eNOS trafficking (Dictyostelium discoideum)
NOSTRIN mediated translocation of eNOS from plasma membrane (Dictyostelium discoideum)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Dictyostelium discoideum)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Dictyostelium discoideum)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
eNOS activation (Dictyostelium discoideum)
AKT1 binds eNOS complex via HSP90 (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
AKT1 phosphorylates eNOS (Dictyostelium discoideum)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
Uncoupled eNOS favours the formation of superoxide (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Dictyostelium discoideum)
myristoylated eNOS dimer [Golgi membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
myristoylated eNOS dimer [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
depalmitoylation of eNOS (Dictyostelium discoideum)
myristoylated eNOS dimer [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
eNOS synthesizes NO (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
eNOS translocation from Golgi to Caveolae (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
Metabolism of nucleotides (Dictyostelium discoideum)
Nucleobase catabolism (Dictyostelium discoideum)
Purine catabolism (Dictyostelium discoideum)
Guanine + H2O => Xanthine + NH4+ (Dictyostelium discoideum)
GDA dimer [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Pyrimidine catabolism (Dictyostelium discoideum)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Dictyostelium discoideum)
DPYS tetramer [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Dictyostelium discoideum)
UPB1:Zn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Nucleotide salvage (Dictyostelium discoideum)
Pyrimidine salvage (Dictyostelium discoideum)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Dictyostelium discoideum)
CDA tetramer [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Metabolism of porphyrins (Dictyostelium discoideum)
Heme biosynthesis (Dictyostelium discoideum)
ALAD binds to Pb2+ (Dictyostelium discoideum)
Zn2+ [cytosol]
8x(ALAD:Zn2+) [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
8xALAD:Pb2+:Zn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
ALAD condenses 2 dALAs to form PBG (Dictyostelium discoideum)
8x(ALAD:Zn2+) [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of cofactors (Dictyostelium discoideum)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Dictyostelium discoideum)
BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
DHNTP is dephosphorylated by PTPS to PTHP (Dictyostelium discoideum)
p-PTPS hexamer [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Dictyostelium discoideum)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Dictyostelium discoideum)
MTR transfers CH3 from MeCbl to HCYS (Dictyostelium discoideum)
MTRR:MTR(MeCbl) [cytosol] (Dictyostelium discoideum)
MTR:Zn2+:MeCbl [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
MTRR:MTR(cob(I)alamin) [cytosol] (Dictyostelium discoideum)
MTR:Zn2+:cob(I)alamin [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
MTR transfers CH3 group from MTHF to cob(I)alamin (Dictyostelium discoideum)
MTRR:MTR(MeCbl) [cytosol] (Dictyostelium discoideum)
MTR:Zn2+:MeCbl [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
MTRR:MTR(cob(I)alamin) [cytosol] (Dictyostelium discoideum)
MTR:Zn2+:cob(I)alamin [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
MTRR reduces cob(II)alamin to meCbl (Dictyostelium discoideum)
MTRR:MTR(MeCbl) [cytosol] (Dictyostelium discoideum)
MTR:Zn2+:MeCbl [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
MTRR:MTR(cob(II)alamin) [cytosol] (Dictyostelium discoideum)
MTRR:MTR [cytosol] (Dictyostelium discoideum)
MTR:Zn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
cob(II)alamin binds to MTRR:MTR (Dictyostelium discoideum)
MTRR:MTR [cytosol] (Dictyostelium discoideum)
MTR:Zn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
MTRR:MTR(cob(II)alamin) [cytosol] (Dictyostelium discoideum)
MTRR:MTR [cytosol] (Dictyostelium discoideum)
MTR:Zn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Molybdenum cofactor biosynthesis (Dictyostelium discoideum)
NFS1 transfers sulfur from cysteine onto MOCS3 (Dictyostelium discoideum)
MOCS3-S-S(1-):Zn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
MOCS3:Zn2+ (red.) [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Nicotinate metabolism (Dictyostelium discoideum)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Dictyostelium discoideum)
NADK:Zn2+ tetramer [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Vitamins B6 activation to pyridoxal phosphate (Dictyostelium discoideum)
2xPDXK:2xZn2+ phosphorylates PXA (Dictyostelium discoideum)
2xPDXK:2xZn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
The citric acid (TCA) cycle and respiratory electron transport (Dictyostelium discoideum)
Pyruvate metabolism and Citric Acid (TCA) cycle (Dictyostelium discoideum)
Pyruvate metabolism (Dictyostelium discoideum)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Dictyostelium discoideum)
HAGH-2:2xZn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Metabolism of proteins (Dictyostelium discoideum)
Peptide hormone metabolism (Dictyostelium discoideum)
Insulin processing (Dictyostelium discoideum)
SLC30A8 transports Zn2+ from cytosol to secretory granule (Dictyostelium discoideum)
Zn2+ [cytosol]
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Dictyostelium discoideum)
Zn2+ [cytosol]
Signal Transduction (Dictyostelium discoideum)
Signaling by Nuclear Receptors (Dictyostelium discoideum)
ESR-mediated signaling (Dictyostelium discoideum)
Non-genomic estrogen signaling (Dictyostelium discoideum)
eNOS synthesizes NO (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
Signaling by Retinoic Acid (Dictyostelium discoideum)
RA biosynthesis pathway (Dictyostelium discoideum)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Dictyostelium discoideum)
ADH1A,1C,4 dimers [cytosol] (Dictyostelium discoideum)
ADH1A:2Zn2+ dimer [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
ADH4:2Zn2+ dimer [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
alcohol dehydrogenase 1 (class I), alpha/beta dimer [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Dictyostelium discoideum)
Signaling by VEGF (Dictyostelium discoideum)
VEGFA-VEGFR2 Pathway (Dictyostelium discoideum)
VEGFR2 mediated vascular permeability (Dictyostelium discoideum)
AKT1 binds eNOS complex via HSP90 (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
AKT1 phosphorylates eNOS (Dictyostelium discoideum)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
eNOS synthesizes NO (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
Zn2+ [cytosol]
Signaling by WNT (Dictyostelium discoideum)
Beta-catenin independent WNT signaling (Dictyostelium discoideum)
Ca2+ pathway (Dictyostelium discoideum)
Activation of Calcineurin (Dictyostelium discoideum)
Calcineurin (CaN) [cytosol] (Dictyostelium discoideum)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Dictyostelium discoideum)
PPP3CA,B:Calmodulin [cytosol] (Dictyostelium discoideum)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Dictyostelium discoideum)
Zn2+ [cytosol]
Translocation of NFATC1:CaN:CaM to nucleus (Dictyostelium discoideum)
NFATC1:CaN:CaM [cytosol] (Dictyostelium discoideum)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Dictyostelium discoideum)
PPP3CA,B:Calmodulin [cytosol] (Dictyostelium discoideum)
![Zn2+ [cytosol] icon](/icon/R-ICO-013542.svg){kind=icon}