Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Zn2+ [cytosol]
Stable Identifier
R-ALL-29426
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
Zn++, zinc(2+), Zinc ion, Zn(II)
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Mycobacterium tuberculosis
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to mechanical stimuli (Bos taurus)
Response of endothelial cells to shear stress (Bos taurus)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Bos taurus)
PKA phosphorylates NOS3 (eNOS) on serine-633 (Bos taurus)
p-S633-eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Bos taurus)
p-S1177,S1179-eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Bos taurus)
PP2A dephosphorylates serine-127 of YAP1 (Bos taurus)
p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Bos taurus)
p-S715-PDE4D5:Zn2+:Mg2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
Cytoprotection by HMOX1 (Bos taurus)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Bos taurus)
BLVRA:Zn2+,BLVRB [cytosol] (Bos taurus)
BLVRA:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Detoxification of Reactive Oxygen Species (Bos taurus)
2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Bos taurus)
2xSOD1:CCS:Zn2+:2xCu1+ dimer [cytosol] (Bos taurus)
CCS:Zn2+:2xCu1+ dimer [cytosol] (Bos taurus)
CCS:Zn2+:2xCu1+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CCS:Zn2+:2xCu1+:SOD1:Zn2+ [cytosol] (Bos taurus)
CCS:Zn2+:2xCu1+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Bos taurus)
2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol] (Bos taurus)
2xHC-SOD1:Zn2+:Cu2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CCS:Zn2+:2xCu1+:SOD1:Zn2+ [cytosol] (Bos taurus)
CCS:Zn2+:2xCu1+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CCS:Zn2+:Cu1+ dimer [cytosol] (Bos taurus)
CCS:Zn2+:Cu1+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Bos taurus)
2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol] (Bos taurus)
2xHC-SOD1:Zn2+:Cu2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Bos taurus)
2xSOD1:CCS:Zn2+:2xCu1+ dimer [cytosol] (Bos taurus)
CCS:Zn2+:2xCu1+ dimer [cytosol] (Bos taurus)
CCS:Zn2+:2xCu1+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CCS:Zn2+:2xCu1+ dimer [cytosol] (Bos taurus)
CCS:Zn2+:2xCu1+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Response to metal ions (Bos taurus)
Metallothioneins bind metals (Bos taurus)
MT1A binds zinc (Bos taurus)
Zn2+ [cytosol]
MT1A:7Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
MT3 binds zinc (Bos taurus)
Zn2+ [cytosol]
MT3:7Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
MT3 exchanges zinc for copper (Bos taurus)
Zn2+ [cytosol]
MT3:4Zn2+:4Cu+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
MT3:7Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Drug ADME (Bos taurus)
Abacavir ADME (Bos taurus)
Abacavir metabolism (Bos taurus)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Bos taurus)
ADH1A:2Zn2+ dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Bos taurus)
ADAL:Zn [cytosol] (Bos taurus)
Zn2+ [cytosol]
Paracetamol ADME (Bos taurus)
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Bos taurus)
ACY1:Zn2+ dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Downstream signaling events of B Cell Receptor (BCR) (Bos taurus)
Calcineurin activates NFAT (Bos taurus)
Calcineurin binds NFATC1,2,3 (Bos taurus)
Calcineurin (CaN) [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Calcineurin:p-NFATC1,2,3 [cytosol] (Bos taurus)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Innate Immune System (Bos taurus)
Antimicrobial peptides (Bos taurus)
Ion influx/efflux at host-pathogen interface (Bos taurus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)
Divalent metals transported by NRAMP1 [cytosol]
Zn2+ [cytosol]
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
CLEC7A (Dectin-1) induces NFAT activation (Bos taurus)
Activation of Calcineurin (Bos taurus)
Calcineurin (CaN) [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Calcineurin binds and dephosphorylates NFAT (Bos taurus)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
NFAT:CaN:CaM [cytosol] (Bos taurus)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Translocation of CaN:CaM:NFAT to nucleus (Bos taurus)
NFAT:CaN:CaM [cytosol] (Bos taurus)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated Ca+2 mobilization (Bos taurus)
Activation of Calcineurin (Bos taurus)
Calcineurin (CaN) [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Calcineurin binds and dephosphorylates NFAT (Bos taurus)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
NFAT:CaN:CaM [cytosol] (Bos taurus)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Translocation of CaN:CaM:NFAT to nucleus (Bos taurus)
NFAT:CaN:CaM [cytosol] (Bos taurus)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
ROS and RNS production in phagocytes (Bos taurus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)
Divalent metals transported by NRAMP1 [cytosol]
Zn2+ [cytosol]
Metabolism (Bos taurus)
Aerobic respiration and respiratory electron transport (Bos taurus)
Pyruvate metabolism (Bos taurus)
GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Bos taurus)
GLO1 dimer:2xZn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Bos taurus)
HAGH-2:2xZn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Biological oxidations (Bos taurus)
Aflatoxin activation and detoxification (Bos taurus)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Bos taurus)
ACY1:Zn2+ dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Bos taurus)
DPEP1,2 dimers [plasma membrane] (Bos taurus)
DPEP1 dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
DPEP2 dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
Phase I - Functionalization of compounds (Bos taurus)
Ethanol oxidation (Bos taurus)
ADH5 oxidises S-HMGSH to S-FGSH (Bos taurus)
ADH5:2xZn2+ dimer [cytosol] (Bos taurus)
ADH5:2xZn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Bos taurus)
alcohol dehydrogenase complex [cytosol] (Bos taurus)
ADH1A:2Zn2+ dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
ADH4:2Zn2+ dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
ADH7:2Zn2+ dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
alcohol dehydrogenase 1 (class I), alpha/beta dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
alcohol dehydrogenase 6 (class V) complex [cytosol] (Bos taurus)
Zn2+ [cytosol]
Phase II - Conjugation of compounds (Bos taurus)
Methylation (Bos taurus)
MTR transfers CH3 from MeCbl to HCYS (Bos taurus)
MTRR:MTR:MeCbl [cytosol] (Bos taurus)
MTR:Zn2+:MeCbl [cytosol] (Bos taurus)
Zn2+ [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Bos taurus)
MTR:Zn2+:cob(I)alamin [cytosol] (Bos taurus)
Zn2+ [cytosol]
Metabolism of amino acids and derivatives (Bos taurus)
Aspartate and asparagine metabolism (Bos taurus)
ASPA deacetylates NAA to acetate and L-aspartate (Bos taurus)
ASPA:Zn2+ dimer [cytosol] (Bos taurus)
ASPA:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Choline catabolism (Bos taurus)
BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Bos taurus)
BHMT:Zn2+ tetramer [cytosol] (Bos taurus)
BHMT:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Sulfur amino acid metabolism (Bos taurus)
BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Bos taurus)
BHMT:Zn2+ tetramer [cytosol] (Bos taurus)
BHMT:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Bos taurus)
BHMT2:Zn2+ tetramer [cytosol] (Bos taurus)
BHMT2:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
MTR transfers CH3 from MeCbl to HCYS (Bos taurus)
MTRR:MTR:MeCbl [cytosol] (Bos taurus)
MTR:Zn2+:MeCbl [cytosol] (Bos taurus)
Zn2+ [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Bos taurus)
MTR:Zn2+:cob(I)alamin [cytosol] (Bos taurus)
Zn2+ [cytosol]
Metabolism of carbohydrates (Bos taurus)
Formation of xylulose-5-phosphate (Bos taurus)
SORD tetramer oxidizes xylitol to D-xylulose (Bos taurus)
SORD tetramer [cytosol] (Bos taurus)
SORD:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Fructose metabolism (Bos taurus)
Fructose biosynthesis (Bos taurus)
SORD oxidizes D-sorbitol to Fru (Bos taurus)
SORD tetramer [cytosol] (Bos taurus)
SORD:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Lysosomal oligosaccharide catabolism (Bos taurus)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Bos taurus)
MAN2C1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Metabolism of lipids (Bos taurus)
Biosynthesis of specialized proresolving mediators (SPMs) (Bos taurus)
Biosynthesis of DHA-derived SPMs (Bos taurus)
Biosynthesis of D-series resolvins (Bos taurus)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Bos taurus)
LTA4H:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Bos taurus)
LTA4H:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Bos taurus)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Bos taurus)
LTA4H:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Bos taurus)
LTA4H:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Biosynthesis of protectins (Bos taurus)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Bos taurus)
LTA4H:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Bos taurus)
LTA4H:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Biosynthesis of EPA-derived SPMs (Bos taurus)
Biosynthesis of E-series 18(R)-resolvins (Bos taurus)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Bos taurus)
LTA4H:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Bos taurus)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Bos taurus)
LTA4H:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Fatty acid metabolism (Bos taurus)
Arachidonate metabolism (Bos taurus)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Bos taurus)
LTA4 is hydolysed to LTB4 by LTA4H (Bos taurus)
LTA4H:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
LTD4 is converted to LTE4 by DPEP1/2 (Bos taurus)
DPEP1,2 dimers [plasma membrane] (Bos taurus)
DPEP1 dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
DPEP2 dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Bos taurus)
NOSIP mediated eNOS trafficking (Bos taurus)
eNOS binds NOSIP (Bos taurus)
eNOS:NOSIP [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Bos taurus)
eNOS:NOSIP [Golgi membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Bos taurus)
Zn2+ [cytosol]
eNOS:NOSIP [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
NOSTRIN mediated eNOS trafficking (Bos taurus)
NOSTRIN mediated translocation of eNOS from plasma membrane (Bos taurus)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Bos taurus)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Bos taurus)
Zn2+ [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Bos taurus)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
eNOS activation (Bos taurus)
AKT1 phosphorylates eNOS (Bos taurus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
eNOS:CaM:HSP90 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
BH2 binding can lead to eNOS uncoupling (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Bos taurus)
eNOS:CaM:HSP90 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
Depalmitoylation of eNOS (Bos taurus)
myristoylated eNOS dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Bos taurus)
eNOS:Caveolin-1:CaM [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
Uncoupled eNOS favours the formation of superoxide (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Bos taurus)
myristoylated eNOS dimer [Golgi membrane] (Bos taurus)
Zn2+ [cytosol]
myristoylated eNOS dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
eNOS associates with Caveolin-1 (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
eNOS synthesizes NO (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
eNOS translocation from Golgi to Caveolae (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
Metabolism of nucleotides (Bos taurus)
Nucleotide catabolism (Bos taurus)
Purine catabolism (Bos taurus)
Guanine + H2O => Xanthine + NH4+ (Bos taurus)
GDA dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
Pyrimidine catabolism (Bos taurus)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Bos taurus)
DPYS tetramer [cytosol] (Bos taurus)
Zn2+ [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Bos taurus)
DPYS tetramer [cytosol] (Bos taurus)
Zn2+ [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Bos taurus)
UPB1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Bos taurus)
UPB1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Nucleotide salvage (Bos taurus)
Purine salvage (Bos taurus)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Bos taurus)
ADAL:Zn [cytosol] (Bos taurus)
Zn2+ [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Bos taurus)
ADAL:Zn [cytosol] (Bos taurus)
Zn2+ [cytosol]
Pyrimidine salvage (Bos taurus)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Bos taurus)
CDA tetramer [cytosol] (Bos taurus)
Zn2+ [cytosol]
Metabolism of porphyrins (Bos taurus)
Heme biosynthesis (Bos taurus)
ALAD condenses 2 dALAs to form PBG (Bos taurus)
8x(ALAD:Zn2+) [cytosol] (Bos taurus)
Zn2+ [cytosol]
8xALAD:Pb2+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Heme degradation (Bos taurus)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Bos taurus)
BLVRA:Zn2+,BLVRB [cytosol] (Bos taurus)
BLVRA:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of cofactors (Bos taurus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Bos taurus)
BH2 binding can lead to eNOS uncoupling (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
DHNTP is dephosphorylated by PTPS to PTHP (Bos taurus)
p-PTPS hexamer [cytosol] (Bos taurus)
Zn2+ [cytosol]
PTPS is phosphorylated by cGMP-dependant protein kinase II (Bos taurus)
p-PTPS hexamer [cytosol] (Bos taurus)
Zn2+ [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Bos taurus)
Cobalamin (Cbl) metabolism (Bos taurus)
MTR transfers CH3 from MeCbl to HCYS (Bos taurus)
MTRR:MTR:MeCbl [cytosol] (Bos taurus)
MTR:Zn2+:MeCbl [cytosol] (Bos taurus)
Zn2+ [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Bos taurus)
MTR:Zn2+:cob(I)alamin [cytosol] (Bos taurus)
Zn2+ [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Bos taurus)
MTRR:MTR:MeCbl [cytosol] (Bos taurus)
MTR:Zn2+:MeCbl [cytosol] (Bos taurus)
Zn2+ [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Bos taurus)
MTR:Zn2+:cob(I)alamin [cytosol] (Bos taurus)
Zn2+ [cytosol]
MTRR reduces cob(II)alamin to meCbl (Bos taurus)
MTRR:MTR:MeCbl [cytosol] (Bos taurus)
MTR:Zn2+:MeCbl [cytosol] (Bos taurus)
Zn2+ [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Bos taurus)
MTRR:MTR [cytosol] (Bos taurus)
MTR:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Bos taurus)
MTRR:MTR [cytosol] (Bos taurus)
MTR:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Bos taurus)
MTRR:MTR [cytosol] (Bos taurus)
MTR:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Molybdenum cofactor biosynthesis (Bos taurus)
PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Bos taurus)
MOCS3-S-S(1-):Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
MOCS3:Zn2+ (red.) [cytosol] (Bos taurus)
Zn2+ [cytosol]
Nicotinate metabolism (Bos taurus)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Bos taurus)
NADK:Zn2+ tetramer [cytosol] (Bos taurus)
Zn2+ [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Bos taurus)
2xPDKX:2xZn2+ phosphorylates PDX (Bos taurus)
2xPDXK:2xZn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
2xPDXK:2xZn2+ phosphorylates PXA (Bos taurus)
2xPDXK:2xZn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
2xPDXK:2xZn2+ phosphorylates PXL (Bos taurus)
2xPDXK:2xZn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Reversible hydration of carbon dioxide (Bos taurus)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Bos taurus)
CA1,2,3,7,13:Zinc [cytosol] (Bos taurus)
CA13:Zinc [cytosol] (Bos taurus)
Zn2+ [cytosol]
CA1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CA3:Zinc [cytosol] (Bos taurus)
Zn2+ [cytosol]
CA7:Zinc [cytosol] (Bos taurus)
Zn2+ [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Bos taurus)
CA1,2,3,7,13:Zinc [cytosol] (Bos taurus)
CA13:Zinc [cytosol] (Bos taurus)
Zn2+ [cytosol]
CA1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CA3:Zinc [cytosol] (Bos taurus)
Zn2+ [cytosol]
CA7:Zinc [cytosol] (Bos taurus)
Zn2+ [cytosol]
Metabolism of proteins (Bos taurus)
Peptide hormone metabolism (Bos taurus)
Insulin processing (Bos taurus)
SLC30A8 transports Zn2+ from cytosol to secretory granule (Bos taurus)
Zn2+ [cytosol]
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Bos taurus)
Zn2+ [cytosol]
ZnT5 transports zinc into the golgi apparatus (Bos taurus)
Zn2+ [cytosol]
ZnT8 transports zinc into the Golgi apparatus (Bos taurus)
Zn2+ [cytosol]
Signal Transduction (Bos taurus)
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Extra-nuclear estrogen signaling (Bos taurus)
eNOS synthesizes NO (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
Signaling by Retinoic Acid (Bos taurus)
RA biosynthesis pathway (Bos taurus)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Bos taurus)
ADH1A,1C,4 dimers [cytosol] (Bos taurus)
ADH1A:2Zn2+ dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
ADH4:2Zn2+ dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
alcohol dehydrogenase 1 (class I), alpha/beta dimer [cytosol] (Bos taurus)
Zn2+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
Signalling to ERKs (Bos taurus)
Prolonged ERK activation events (Bos taurus)
Frs2-mediated activation (Bos taurus)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Bos taurus)
BRAF dimer complex [cytosol] (Bos taurus)
B-Raf complex [cytosol] (Bos taurus)
Zn2+ [cytosol]
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Bos taurus)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Bos taurus)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Bos taurus)
Zn2+ [cytosol]
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Bos taurus)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Bos taurus)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Bos taurus)
Zn2+ [cytosol]
Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Bos taurus)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Bos taurus)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Bos taurus)
Zn2+ [cytosol]
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Bos taurus)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Bos taurus)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Bos taurus)
Zn2+ [cytosol]
BRAF autophosphorylates downstream of RAP1 and NGF (Bos taurus)
BRAF dimer complex [cytosol] (Bos taurus)
B-Raf complex [cytosol] (Bos taurus)
Zn2+ [cytosol]
RAP1:GTP:B-Raf complex [endosome membrane] (Bos taurus)
BRAF dimer complex [cytosol] (Bos taurus)
B-Raf complex [cytosol] (Bos taurus)
Zn2+ [cytosol]
RAP1:GTP:activated BRAF dimer [endosome membrane] (Bos taurus)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Bos taurus)
Zn2+ [cytosol]
Dissociation of phosphorylated MAP2Ks and MAPKs (Bos taurus)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Bos taurus)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Bos taurus)
Zn2+ [cytosol]
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Bos taurus)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Bos taurus)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Bos taurus)
Zn2+ [cytosol]
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Bos taurus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Bos taurus)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Bos taurus)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Bos taurus)
Zn2+ [cytosol]
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Bos taurus)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Bos taurus)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Bos taurus)
Zn2+ [cytosol]
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
VEGFR2 mediated vascular permeability (Bos taurus)
AKT1 phosphorylates eNOS (Bos taurus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
eNOS:CaM:HSP90 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Bos taurus)
eNOS:CaM:HSP90 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Bos taurus)
eNOS:Caveolin-1:CaM [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
eNOS synthesizes NO (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
Zn2+ [cytosol]
Signaling by WNT (Bos taurus)
Beta-catenin independent WNT signaling (Bos taurus)
Ca2+ pathway (Bos taurus)
Activation of Calcineurin (Bos taurus)
Calcineurin (CaN) [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Bos taurus)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
NFATC1:CaN:CaM [cytosol] (Bos taurus)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Translocation of NFATC1:CaN:CaM to nucleus (Bos taurus)
NFATC1:CaN:CaM [cytosol] (Bos taurus)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Bos taurus)
PPP3CA,B:Calmodulin [cytosol] (Bos taurus)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Transport of small molecules (Bos taurus)
O2/CO2 exchange in erythrocytes (Bos taurus)
Erythrocytes take up carbon dioxide and release oxygen (Bos taurus)
CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Bos taurus)
CA1:Zn2+,CA2:Zn2+ [cytosol] (Bos taurus)
CA1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CA1:Zn2+,CA2:Zn2+:CA inhibitors [cytosol] (Bos taurus)
CA1:Zn2+,CA2:Zn2+ [cytosol] (Bos taurus)
CA1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Bos taurus)
CA1:Zn2+,CA2:Zn2+ [cytosol] (Bos taurus)
CA1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Bos taurus)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Bos taurus)
CA1:Zn2+,CA2:Zn2+ [cytosol] (Bos taurus)
CA1:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Bos taurus)
Zn2+ [cytosol]
SLC-mediated transmembrane transport (Bos taurus)
Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
Metal ion SLC transporters (Bos taurus)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)
Divalent metals transported by NRAMP1 [cytosol]
Zn2+ [cytosol]
Zinc transporters (Bos taurus)
Zinc efflux and compartmentalization by the SLC30 family (Bos taurus)
SLC30A8 transports Zn2+ from cytosol to secretory granule (Bos taurus)
Zn2+ [cytosol]
ZnT1 mediates the efflux of zinc from the cell (Bos taurus)
Zn2+ [cytosol]
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Bos taurus)
Zn2+ [cytosol]
ZnT5 transports zinc into the golgi apparatus (Bos taurus)
Zn2+ [cytosol]
ZnT8 transports zinc into the Golgi apparatus (Bos taurus)
Zn2+ [cytosol]
Zinc influx into cells by the SLC39 gene family (Bos taurus)
SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Bos taurus)
Zn2+ [cytosol]
ZIP6 and ZIP14 mediate zinc influx into cells (Bos taurus)
Zn2+ [cytosol]
ZIP7 mediates zinc efflux from the endoplasmic reticulum (Bos taurus)
Zn2+ [cytosol]
ZIP8 mediates zinc influx into cells (Bos taurus)
Zn2+ [cytosol]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to mechanical stimuli (Caenorhabditis elegans)
Response of endothelial cells to shear stress (Caenorhabditis elegans)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Caenorhabditis elegans)
PP2A dephosphorylates serine-127 of YAP1 (Caenorhabditis elegans)
p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Caenorhabditis elegans)
p-S715-PDE4D5:Zn2+:Mg2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to chemical stress (Caenorhabditis elegans)
Detoxification of Reactive Oxygen Species (Caenorhabditis elegans)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Caenorhabditis elegans)
2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol] (Caenorhabditis elegans)
2xHC-SOD1:Zn2+:Cu2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Drug ADME (Caenorhabditis elegans)
Abacavir ADME (Caenorhabditis elegans)
Abacavir metabolism (Caenorhabditis elegans)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Caenorhabditis elegans)
ADH1A:2Zn2+ dimer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Caenorhabditis elegans)
ADAL:Zn [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Paracetamol ADME (Caenorhabditis elegans)
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Caenorhabditis elegans)
ACY1:Zn2+ dimer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Immune System (Caenorhabditis elegans)
Innate Immune System (Caenorhabditis elegans)
Antimicrobial peptides (Caenorhabditis elegans)
Ion influx/efflux at host-pathogen interface (Caenorhabditis elegans)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)
Divalent metals transported by NRAMP1 [cytosol]
Zn2+ [cytosol]
C-type lectin receptors (CLRs) (Caenorhabditis elegans)
CLEC7A (Dectin-1) signaling (Caenorhabditis elegans)
CLEC7A (Dectin-1) induces NFAT activation (Caenorhabditis elegans)
Activation of Calcineurin (Caenorhabditis elegans)
Calcineurin (CaN) [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Calmodulin [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Translocation of CaN:CaM:NFAT to nucleus (Caenorhabditis elegans)
NFAT:CaN:CaM [cytosol] (Caenorhabditis elegans)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Calmodulin [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Fc epsilon receptor (FCERI) signaling (Caenorhabditis elegans)
FCERI mediated Ca+2 mobilization (Caenorhabditis elegans)
Activation of Calcineurin (Caenorhabditis elegans)
Calcineurin (CaN) [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Calmodulin [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Translocation of CaN:CaM:NFAT to nucleus (Caenorhabditis elegans)
NFAT:CaN:CaM [cytosol] (Caenorhabditis elegans)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Calmodulin [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
ROS and RNS production in phagocytes (Caenorhabditis elegans)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)
Divalent metals transported by NRAMP1 [cytosol]
Zn2+ [cytosol]
Metabolism (Caenorhabditis elegans)
Aerobic respiration and respiratory electron transport (Caenorhabditis elegans)
Pyruvate metabolism (Caenorhabditis elegans)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Caenorhabditis elegans)
HAGH-2:2xZn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Biological oxidations (Caenorhabditis elegans)
Aflatoxin activation and detoxification (Caenorhabditis elegans)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Caenorhabditis elegans)
ACY1:Zn2+ dimer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Phase I - Functionalization of compounds (Caenorhabditis elegans)
Ethanol oxidation (Caenorhabditis elegans)
ADH5 oxidises S-HMGSH to S-FGSH (Caenorhabditis elegans)
ADH5:2xZn2+ dimer [cytosol] (Caenorhabditis elegans)
ADH5:2xZn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Caenorhabditis elegans)
alcohol dehydrogenase complex [cytosol] (Caenorhabditis elegans)
ADH1A:2Zn2+ dimer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
ADH4:2Zn2+ dimer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
ADH7:2Zn2+ dimer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
alcohol dehydrogenase 1 (class I), alpha/beta dimer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
alcohol dehydrogenase 6 (class V) complex [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Phase II - Conjugation of compounds (Caenorhabditis elegans)
Methylation (Caenorhabditis elegans)
MTR transfers CH3 from MeCbl to HCYS (Caenorhabditis elegans)
MTRR:MTR:MeCbl [cytosol] (Caenorhabditis elegans)
MTR:Zn2+:MeCbl [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Caenorhabditis elegans)
MTR:Zn2+:cob(I)alamin [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Sulfur amino acid metabolism (Caenorhabditis elegans)
MTR transfers CH3 from MeCbl to HCYS (Caenorhabditis elegans)
MTRR:MTR:MeCbl [cytosol] (Caenorhabditis elegans)
MTR:Zn2+:MeCbl [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Caenorhabditis elegans)
MTR:Zn2+:cob(I)alamin [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Metabolism of carbohydrates (Caenorhabditis elegans)
Formation of xylulose-5-phosphate (Caenorhabditis elegans)
SORD tetramer oxidizes xylitol to D-xylulose (Caenorhabditis elegans)
SORD tetramer [cytosol] (Caenorhabditis elegans)
SORD:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Fructose metabolism (Caenorhabditis elegans)
Fructose biosynthesis (Caenorhabditis elegans)
SORD oxidizes D-sorbitol to Fru (Caenorhabditis elegans)
SORD tetramer [cytosol] (Caenorhabditis elegans)
SORD:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Metabolism of lipids (Caenorhabditis elegans)
Biosynthesis of specialized proresolving mediators (SPMs) (Caenorhabditis elegans)
Biosynthesis of DHA-derived SPMs (Caenorhabditis elegans)
Biosynthesis of D-series resolvins (Caenorhabditis elegans)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Caenorhabditis elegans)
LTA4H:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Caenorhabditis elegans)
LTA4H:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Caenorhabditis elegans)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Caenorhabditis elegans)
LTA4H:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Caenorhabditis elegans)
LTA4H:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Biosynthesis of protectins (Caenorhabditis elegans)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Caenorhabditis elegans)
LTA4H:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Caenorhabditis elegans)
LTA4H:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Biosynthesis of EPA-derived SPMs (Caenorhabditis elegans)
Biosynthesis of E-series 18(R)-resolvins (Caenorhabditis elegans)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Caenorhabditis elegans)
LTA4H:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Caenorhabditis elegans)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Caenorhabditis elegans)
LTA4H:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Fatty acid metabolism (Caenorhabditis elegans)
Arachidonate metabolism (Caenorhabditis elegans)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Caenorhabditis elegans)
LTA4 is hydolysed to LTB4 by LTA4H (Caenorhabditis elegans)
LTA4H:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Caenorhabditis elegans)
eNOS activation (Caenorhabditis elegans)
AKT1 phosphorylates eNOS (Caenorhabditis elegans)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
eNOS:CaM:HSP90 [plasma membrane] (Caenorhabditis elegans)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
Uncoupled eNOS favours the formation of superoxide (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
Metabolism of nucleotides (Caenorhabditis elegans)
Nucleotide catabolism (Caenorhabditis elegans)
Pyrimidine catabolism (Caenorhabditis elegans)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Caenorhabditis elegans)
DPYS tetramer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Caenorhabditis elegans)
DPYS tetramer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Caenorhabditis elegans)
UPB1:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Caenorhabditis elegans)
UPB1:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Nucleotide salvage (Caenorhabditis elegans)
Purine salvage (Caenorhabditis elegans)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Caenorhabditis elegans)
ADAL:Zn [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Caenorhabditis elegans)
ADAL:Zn [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Pyrimidine salvage (Caenorhabditis elegans)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Caenorhabditis elegans)
CDA tetramer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of cofactors (Caenorhabditis elegans)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Caenorhabditis elegans)
BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
DHNTP is dephosphorylated by PTPS to PTHP (Caenorhabditis elegans)
p-PTPS hexamer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Caenorhabditis elegans)
Cobalamin (Cbl) metabolism (Caenorhabditis elegans)
MTR transfers CH3 from MeCbl to HCYS (Caenorhabditis elegans)
MTRR:MTR:MeCbl [cytosol] (Caenorhabditis elegans)
MTR:Zn2+:MeCbl [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Caenorhabditis elegans)
MTR:Zn2+:cob(I)alamin [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Caenorhabditis elegans)
MTRR:MTR:MeCbl [cytosol] (Caenorhabditis elegans)
MTR:Zn2+:MeCbl [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Caenorhabditis elegans)
MTR:Zn2+:cob(I)alamin [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
MTRR reduces cob(II)alamin to meCbl (Caenorhabditis elegans)
MTRR:MTR:MeCbl [cytosol] (Caenorhabditis elegans)
MTR:Zn2+:MeCbl [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Caenorhabditis elegans)
MTRR:MTR [cytosol] (Caenorhabditis elegans)
MTR:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Caenorhabditis elegans)
MTRR:MTR [cytosol] (Caenorhabditis elegans)
MTR:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Caenorhabditis elegans)
MTRR:MTR [cytosol] (Caenorhabditis elegans)
MTR:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Molybdenum cofactor biosynthesis (Caenorhabditis elegans)
PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Caenorhabditis elegans)
MOCS3-S-S(1-):Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
MOCS3:Zn2+ (red.) [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Caenorhabditis elegans)
2xPDKX:2xZn2+ phosphorylates PDX (Caenorhabditis elegans)
2xPDXK:2xZn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
2xPDXK:2xZn2+ phosphorylates PXA (Caenorhabditis elegans)
2xPDXK:2xZn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
2xPDXK:2xZn2+ phosphorylates PXL (Caenorhabditis elegans)
2xPDXK:2xZn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Reversible hydration of carbon dioxide (Caenorhabditis elegans)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Caenorhabditis elegans)
CA1,2,3,7,13:Zinc [cytosol] (Caenorhabditis elegans)
CA13:Zinc [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
CA1:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
CA7:Zinc [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Caenorhabditis elegans)
CA1,2,3,7,13:Zinc [cytosol] (Caenorhabditis elegans)
CA13:Zinc [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
CA1:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
CA7:Zinc [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Metabolism of proteins (Caenorhabditis elegans)
Peptide hormone metabolism (Caenorhabditis elegans)
Insulin processing (Caenorhabditis elegans)
SLC30A8 transports Zn2+ from cytosol to secretory granule (Caenorhabditis elegans)
Zn2+ [cytosol]
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Caenorhabditis elegans)
Zn2+ [cytosol]
ZnT5 transports zinc into the golgi apparatus (Caenorhabditis elegans)
Zn2+ [cytosol]
ZnT8 transports zinc into the Golgi apparatus (Caenorhabditis elegans)
Zn2+ [cytosol]
Signal Transduction (Caenorhabditis elegans)
Signaling by Nuclear Receptors (Caenorhabditis elegans)
ESR-mediated signaling (Caenorhabditis elegans)
Extra-nuclear estrogen signaling (Caenorhabditis elegans)
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
Signaling by Retinoic Acid (Caenorhabditis elegans)
RA biosynthesis pathway (Caenorhabditis elegans)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Caenorhabditis elegans)
ADH1A,1C,4 dimers [cytosol] (Caenorhabditis elegans)
ADH1A:2Zn2+ dimer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
ADH4:2Zn2+ dimer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
alcohol dehydrogenase 1 (class I), alpha/beta dimer [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by NTRKs (Caenorhabditis elegans)
Signaling by NTRK1 (TRKA) (Caenorhabditis elegans)
Signalling to ERKs (Caenorhabditis elegans)
Prolonged ERK activation events (Caenorhabditis elegans)
Frs2-mediated activation (Caenorhabditis elegans)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Caenorhabditis elegans)
BRAF dimer complex [cytosol] (Caenorhabditis elegans)
B-Raf complex [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Caenorhabditis elegans)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Caenorhabditis elegans)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Caenorhabditis elegans)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Caenorhabditis elegans)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Caenorhabditis elegans)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Caenorhabditis elegans)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Caenorhabditis elegans)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Caenorhabditis elegans)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
BRAF autophosphorylates downstream of RAP1 and NGF (Caenorhabditis elegans)
BRAF dimer complex [cytosol] (Caenorhabditis elegans)
B-Raf complex [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
RAP1:GTP:B-Raf complex [endosome membrane] (Caenorhabditis elegans)
BRAF dimer complex [cytosol] (Caenorhabditis elegans)
B-Raf complex [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
RAP1:GTP:activated BRAF dimer [endosome membrane] (Caenorhabditis elegans)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Dissociation of phosphorylated MAP2Ks and MAPKs (Caenorhabditis elegans)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Caenorhabditis elegans)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Caenorhabditis elegans)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Caenorhabditis elegans)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Caenorhabditis elegans)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Caenorhabditis elegans)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Caenorhabditis elegans)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Caenorhabditis elegans)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Caenorhabditis elegans)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
VEGFR2 mediated vascular permeability (Caenorhabditis elegans)
AKT1 phosphorylates eNOS (Caenorhabditis elegans)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
eNOS:CaM:HSP90 [plasma membrane] (Caenorhabditis elegans)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
Zn2+ [cytosol]
Signaling by WNT (Caenorhabditis elegans)
Beta-catenin independent WNT signaling (Caenorhabditis elegans)
Ca2+ pathway (Caenorhabditis elegans)
Activation of Calcineurin (Caenorhabditis elegans)
Calcineurin (CaN) [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Calmodulin [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Translocation of NFATC1:CaN:CaM to nucleus (Caenorhabditis elegans)
NFATC1:CaN:CaM [cytosol] (Caenorhabditis elegans)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Calmodulin [cytosol] (Caenorhabditis elegans)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Transport of small molecules (Caenorhabditis elegans)
O2/CO2 exchange in erythrocytes (Caenorhabditis elegans)
Erythrocytes take up carbon dioxide and release oxygen (Caenorhabditis elegans)
CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Caenorhabditis elegans)
CA1:Zn2+,CA2:Zn2+ [cytosol] (Caenorhabditis elegans)
CA1:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
CA1:Zn2+,CA2:Zn2+:CA inhibitors [cytosol] (Caenorhabditis elegans)
CA1:Zn2+,CA2:Zn2+ [cytosol] (Caenorhabditis elegans)
CA1:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Caenorhabditis elegans)
CA1:Zn2+,CA2:Zn2+ [cytosol] (Caenorhabditis elegans)
CA1:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Caenorhabditis elegans)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Caenorhabditis elegans)
CA1:Zn2+,CA2:Zn2+ [cytosol] (Caenorhabditis elegans)
CA1:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Caenorhabditis elegans)
Zn2+ [cytosol]
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of bile salts and organic acids, metal ions and amine compounds (Caenorhabditis elegans)
Metal ion SLC transporters (Caenorhabditis elegans)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)
Divalent metals transported by NRAMP1 [cytosol]
Zn2+ [cytosol]
Zinc transporters (Caenorhabditis elegans)
Zinc efflux and compartmentalization by the SLC30 family (Caenorhabditis elegans)
SLC30A8 transports Zn2+ from cytosol to secretory granule (Caenorhabditis elegans)
Zn2+ [cytosol]
ZnT1 mediates the efflux of zinc from the cell (Caenorhabditis elegans)
Zn2+ [cytosol]
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Caenorhabditis elegans)
Zn2+ [cytosol]
ZnT5 transports zinc into the golgi apparatus (Caenorhabditis elegans)
Zn2+ [cytosol]
ZnT8 transports zinc into the Golgi apparatus (Caenorhabditis elegans)
Zn2+ [cytosol]
Zinc influx into cells by the SLC39 gene family (Caenorhabditis elegans)
SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Caenorhabditis elegans)
Zn2+ [cytosol]
ZIP6 and ZIP14 mediate zinc influx into cells (Caenorhabditis elegans)
Zn2+ [cytosol]
ZIP7 mediates zinc efflux from the endoplasmic reticulum (Caenorhabditis elegans)
Zn2+ [cytosol]
ZIP8 mediates zinc influx into cells (Caenorhabditis elegans)
Zn2+ [cytosol]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to mechanical stimuli (Canis familiaris)
Response of endothelial cells to shear stress (Canis familiaris)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Canis familiaris)
PP2A dephosphorylates serine-127 of YAP1 (Canis familiaris)
p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Canis familiaris)
p-S715-PDE4D5:Zn2+:Mg2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
Cytoprotection by HMOX1 (Canis familiaris)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Canis familiaris)
BLVRA:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Detoxification of Reactive Oxygen Species (Canis familiaris)
2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Canis familiaris)
2xSOD1:CCS:Zn2+:2xCu1+ dimer [cytosol] (Canis familiaris)
CCS:Zn2+:2xCu1+ dimer [cytosol] (Canis familiaris)
CCS:Zn2+:2xCu1+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CCS:Zn2+:2xCu1+:SOD1:Zn2+ [cytosol] (Canis familiaris)
CCS:Zn2+:2xCu1+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Canis familiaris)
2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol] (Canis familiaris)
2xHC-SOD1:Zn2+:Cu2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CCS:Zn2+:2xCu1+:SOD1:Zn2+ [cytosol] (Canis familiaris)
CCS:Zn2+:2xCu1+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CCS:Zn2+:Cu1+ dimer [cytosol] (Canis familiaris)
CCS:Zn2+:Cu1+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Canis familiaris)
2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol] (Canis familiaris)
2xHC-SOD1:Zn2+:Cu2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Canis familiaris)
2xSOD1:CCS:Zn2+:2xCu1+ dimer [cytosol] (Canis familiaris)
CCS:Zn2+:2xCu1+ dimer [cytosol] (Canis familiaris)
CCS:Zn2+:2xCu1+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CCS:Zn2+:2xCu1+ dimer [cytosol] (Canis familiaris)
CCS:Zn2+:2xCu1+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
SOD1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Response to metal ions (Canis familiaris)
Metallothioneins bind metals (Canis familiaris)
MT1A binds zinc (Canis familiaris)
Zn2+ [cytosol]
MT1A:7Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MT3 binds zinc (Canis familiaris)
Zn2+ [cytosol]
MT3:7Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MT3 exchanges zinc for copper (Canis familiaris)
Zn2+ [cytosol]
MT3:4Zn2+:4Cu+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MT3:7Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Drug ADME (Canis familiaris)
Abacavir ADME (Canis familiaris)
Abacavir metabolism (Canis familiaris)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Canis familiaris)
ADH1A:2Zn2+ dimer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Canis familiaris)
ADAL:Zn [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Paracetamol ADME (Canis familiaris)
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Canis familiaris)
ACY1:Zn2+ dimer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Downstream signaling events of B Cell Receptor (BCR) (Canis familiaris)
Calcineurin activates NFAT (Canis familiaris)
Calcineurin binds NFATC1,2,3 (Canis familiaris)
Calcineurin (CaN) [cytosol] (Canis familiaris)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Calcineurin:p-NFATC1,2,3 [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Innate Immune System (Canis familiaris)
Antimicrobial peptides (Canis familiaris)
Ion influx/efflux at host-pathogen interface (Canis familiaris)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Canis familiaris)
Divalent metals transported by NRAMP1 [cytosol]
Zn2+ [cytosol]
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
CLEC7A (Dectin-1) induces NFAT activation (Canis familiaris)
Activation of Calcineurin (Canis familiaris)
Calcineurin (CaN) [cytosol] (Canis familiaris)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Calcineurin binds and dephosphorylates NFAT (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
NFAT:CaN:CaM [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Translocation of CaN:CaM:NFAT to nucleus (Canis familiaris)
NFAT:CaN:CaM [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Activation of Calcineurin (Canis familiaris)
Calcineurin (CaN) [cytosol] (Canis familiaris)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Calcineurin binds and dephosphorylates NFAT (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
NFAT:CaN:CaM [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Translocation of CaN:CaM:NFAT to nucleus (Canis familiaris)
NFAT:CaN:CaM [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
ROS and RNS production in phagocytes (Canis familiaris)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Canis familiaris)
Divalent metals transported by NRAMP1 [cytosol]
Zn2+ [cytosol]
Metabolism (Canis familiaris)
Aerobic respiration and respiratory electron transport (Canis familiaris)
Pyruvate metabolism (Canis familiaris)
GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Canis familiaris)
GLO1 dimer:2xZn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Canis familiaris)
HAGH-2:2xZn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Biological oxidations (Canis familiaris)
Aflatoxin activation and detoxification (Canis familiaris)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Canis familiaris)
ACY1:Zn2+ dimer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Canis familiaris)
DPEP1,2 dimers [plasma membrane] (Canis familiaris)
DPEP1 dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
DPEP2 dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
Phase I - Functionalization of compounds (Canis familiaris)
Ethanol oxidation (Canis familiaris)
ADH5 oxidises S-HMGSH to S-FGSH (Canis familiaris)
ADH5:2xZn2+ dimer [cytosol] (Canis familiaris)
ADH5:2xZn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Canis familiaris)
alcohol dehydrogenase complex [cytosol] (Canis familiaris)
ADH1A:2Zn2+ dimer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
ADH4:2Zn2+ dimer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
alcohol dehydrogenase 1 (class I), alpha/beta dimer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Phase II - Conjugation of compounds (Canis familiaris)
Methylation (Canis familiaris)
MTR transfers CH3 from MeCbl to HCYS (Canis familiaris)
MTRR:MTR:MeCbl [cytosol] (Canis familiaris)
MTR:Zn2+:MeCbl [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Canis familiaris)
MTR:Zn2+:cob(I)alamin [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Metabolism of amino acids and derivatives (Canis familiaris)
Aspartate and asparagine metabolism (Canis familiaris)
ASPA deacetylates NAA to acetate and L-aspartate (Canis familiaris)
ASPA:Zn2+ dimer [cytosol] (Canis familiaris)
ASPA:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Choline catabolism (Canis familiaris)
BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Canis familiaris)
BHMT:Zn2+ tetramer [cytosol] (Canis familiaris)
BHMT:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Sulfur amino acid metabolism (Canis familiaris)
BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Canis familiaris)
BHMT:Zn2+ tetramer [cytosol] (Canis familiaris)
BHMT:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Canis familiaris)
BHMT2:Zn2+ tetramer [cytosol] (Canis familiaris)
BHMT2:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MTR transfers CH3 from MeCbl to HCYS (Canis familiaris)
MTRR:MTR:MeCbl [cytosol] (Canis familiaris)
MTR:Zn2+:MeCbl [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Canis familiaris)
MTR:Zn2+:cob(I)alamin [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Metabolism of carbohydrates (Canis familiaris)
Formation of xylulose-5-phosphate (Canis familiaris)
SORD tetramer oxidizes xylitol to D-xylulose (Canis familiaris)
SORD tetramer [cytosol] (Canis familiaris)
SORD:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Fructose metabolism (Canis familiaris)
Fructose biosynthesis (Canis familiaris)
SORD oxidizes D-sorbitol to Fru (Canis familiaris)
SORD tetramer [cytosol] (Canis familiaris)
SORD:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Lysosomal oligosaccharide catabolism (Canis familiaris)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Canis familiaris)
MAN2C1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Metabolism of lipids (Canis familiaris)
Biosynthesis of specialized proresolving mediators (SPMs) (Canis familiaris)
Biosynthesis of DHA-derived SPMs (Canis familiaris)
Biosynthesis of D-series resolvins (Canis familiaris)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Canis familiaris)
LTA4H:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Canis familiaris)
LTA4H:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Canis familiaris)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Canis familiaris)
LTA4H:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Canis familiaris)
LTA4H:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Biosynthesis of protectins (Canis familiaris)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Canis familiaris)
LTA4H:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Canis familiaris)
LTA4H:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Biosynthesis of EPA-derived SPMs (Canis familiaris)
Biosynthesis of E-series 18(R)-resolvins (Canis familiaris)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Canis familiaris)
LTA4H:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Canis familiaris)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Canis familiaris)
LTA4H:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Fatty acid metabolism (Canis familiaris)
Arachidonate metabolism (Canis familiaris)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Canis familiaris)
LTA4 is hydolysed to LTB4 by LTA4H (Canis familiaris)
LTA4H:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
LTD4 is converted to LTE4 by DPEP1/2 (Canis familiaris)
DPEP1,2 dimers [plasma membrane] (Canis familiaris)
DPEP1 dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
DPEP2 dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Canis familiaris)
NOSTRIN mediated eNOS trafficking (Canis familiaris)
NOSTRIN mediated translocation of eNOS from plasma membrane (Canis familiaris)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Canis familiaris)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Canis familiaris)
Zn2+ [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Canis familiaris)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
Zn2+ [cytosol]
Metabolism of nucleotides (Canis familiaris)
Nucleotide catabolism (Canis familiaris)
Purine catabolism (Canis familiaris)
Guanine + H2O => Xanthine + NH4+ (Canis familiaris)
GDA dimer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Pyrimidine catabolism (Canis familiaris)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Canis familiaris)
DPYS tetramer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Canis familiaris)
DPYS tetramer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Canis familiaris)
UPB1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Canis familiaris)
UPB1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Nucleotide salvage (Canis familiaris)
Purine salvage (Canis familiaris)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Canis familiaris)
ADAL:Zn [cytosol] (Canis familiaris)
Zn2+ [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Canis familiaris)
ADAL:Zn [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Pyrimidine salvage (Canis familiaris)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Canis familiaris)
CDA tetramer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Metabolism of porphyrins (Canis familiaris)
Heme biosynthesis (Canis familiaris)
ALAD condenses 2 dALAs to form PBG (Canis familiaris)
8x(ALAD:Zn2+) [cytosol] (Canis familiaris)
Zn2+ [cytosol]
8xALAD:Pb2+:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Heme degradation (Canis familiaris)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Canis familiaris)
BLVRA:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Canis familiaris)
Cobalamin (Cbl) metabolism (Canis familiaris)
MTR transfers CH3 from MeCbl to HCYS (Canis familiaris)
MTRR:MTR:MeCbl [cytosol] (Canis familiaris)
MTR:Zn2+:MeCbl [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Canis familiaris)
MTR:Zn2+:cob(I)alamin [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Canis familiaris)
MTRR:MTR:MeCbl [cytosol] (Canis familiaris)
MTR:Zn2+:MeCbl [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Canis familiaris)
MTR:Zn2+:cob(I)alamin [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MTRR reduces cob(II)alamin to meCbl (Canis familiaris)
MTRR:MTR:MeCbl [cytosol] (Canis familiaris)
MTR:Zn2+:MeCbl [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Canis familiaris)
MTRR:MTR [cytosol] (Canis familiaris)
MTR:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Canis familiaris)
MTRR:MTR [cytosol] (Canis familiaris)
MTR:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Canis familiaris)
MTRR:MTR [cytosol] (Canis familiaris)
MTR:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Molybdenum cofactor biosynthesis (Canis familiaris)
PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Canis familiaris)
MOCS3-S-S(1-):Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
MOCS3:Zn2+ (red.) [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Nicotinate metabolism (Canis familiaris)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Canis familiaris)
NADK:Zn2+ tetramer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Canis familiaris)
2xPDKX:2xZn2+ phosphorylates PDX (Canis familiaris)
2xPDXK:2xZn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
2xPDXK:2xZn2+ phosphorylates PXA (Canis familiaris)
2xPDXK:2xZn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
2xPDXK:2xZn2+ phosphorylates PXL (Canis familiaris)
2xPDXK:2xZn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Reversible hydration of carbon dioxide (Canis familiaris)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Canis familiaris)
CA1,2,3,7,13:Zinc [cytosol] (Canis familiaris)
CA13:Zinc [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CA1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CA3:Zinc [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CA7:Zinc [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Canis familiaris)
CA1,2,3,7,13:Zinc [cytosol] (Canis familiaris)
CA13:Zinc [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CA1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CA3:Zinc [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CA7:Zinc [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Metabolism of proteins (Canis familiaris)
Peptide hormone metabolism (Canis familiaris)
Insulin processing (Canis familiaris)
SLC30A8 transports Zn2+ from cytosol to secretory granule (Canis familiaris)
Zn2+ [cytosol]
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Canis familiaris)
Zn2+ [cytosol]
ZnT5 transports zinc into the golgi apparatus (Canis familiaris)
Zn2+ [cytosol]
ZnT8 transports zinc into the Golgi apparatus (Canis familiaris)
Zn2+ [cytosol]
Signal Transduction (Canis familiaris)
Signaling by Nuclear Receptors (Canis familiaris)
Signaling by Retinoic Acid (Canis familiaris)
RA biosynthesis pathway (Canis familiaris)
ADH1A,1C,4 oxidise atROL to atRAL in vitro (Canis familiaris)
alcohol dehydrogenase complex [cytosol] (Canis familiaris)
ADH1A:2Zn2+ dimer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
ADH4:2Zn2+ dimer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
alcohol dehydrogenase 1 (class I), alpha/beta dimer [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Signaling by WNT (Canis familiaris)
Beta-catenin independent WNT signaling (Canis familiaris)
Ca2+ pathway (Canis familiaris)
Activation of Calcineurin (Canis familiaris)
Calcineurin (CaN) [cytosol] (Canis familiaris)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
NFATC1:CaN:CaM [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Translocation of NFATC1:CaN:CaM to nucleus (Canis familiaris)
NFATC1:CaN:CaM [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Transport of small molecules (Canis familiaris)
O2/CO2 exchange in erythrocytes (Canis familiaris)
Erythrocytes take up carbon dioxide and release oxygen (Canis familiaris)
CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Canis familiaris)
CA1:Zn2+,CA2:Zn2+ [cytosol] (Canis familiaris)
CA1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CA1:Zn2+,CA2:Zn2+:CA inhibitors [cytosol] (Canis familiaris)
CA1:Zn2+,CA2:Zn2+ [cytosol] (Canis familiaris)
CA1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Canis familiaris)
CA1:Zn2+,CA2:Zn2+ [cytosol] (Canis familiaris)
CA1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Canis familiaris)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Canis familiaris)
CA1:Zn2+,CA2:Zn2+ [cytosol] (Canis familiaris)
CA1:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
CA2:Zn2+ [cytosol] (Canis familiaris)
Zn2+ [cytosol]
SLC-mediated transmembrane transport (Canis familiaris)
Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
Metal ion SLC transporters (Canis familiaris)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Canis familiaris)
Divalent metals transported by NRAMP1 [cytosol]
Zn2+ [cytosol]
Zinc transporters (Canis familiaris)
Zinc efflux and compartmentalization by the SLC30 family (Canis familiaris)
SLC30A8 transports Zn2+ from cytosol to secretory granule (Canis familiaris)
Zn2+ [cytosol]
ZnT1 mediates the efflux of zinc from the cell (Canis familiaris)
Zn2+ [cytosol]
ZnT5 transports zinc into secretory granules in pancreatic beta cells (Canis familiaris)
Zn2+ [cytosol]
ZnT5 transports zinc into the golgi apparatus (Canis familiaris)
Zn2+ [cytosol]
ZnT8 transports zinc into the Golgi apparatus (Canis familiaris)
Zn2+ [cytosol]
Zinc influx into cells by the SLC39 gene family (Canis familiaris)
SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Canis familiaris)
Zn2+ [cytosol]
ZIP6 and ZIP14 mediate zinc influx into cells (Canis familiaris)
Zn2+ [cytosol]
ZIP7 mediates zinc efflux from the endoplasmic reticulum (Canis familiaris)
Zn2+ [cytosol]
ZIP8 mediates zinc influx into cells (Canis familiaris)
Zn2+ [cytosol]
Cellular responses to stimuli (Danio rerio)
Cellular responses to mechanical stimuli (Danio rerio)
Response of endothelial cells to shear stress (Danio rerio)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Danio rerio)
PP2A dephosphorylates serine-127 of YAP1 (Danio rerio)
p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Danio rerio)
p-S715-PDE4D5:Zn2+:Mg2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Cellular responses to stress (Danio rerio)
Cellular response to chemical stress (Danio rerio)
Cytoprotection by HMOX1 (Danio rerio)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Danio rerio)
BLVRA:Zn2+,BLVRB [cytosol] (Danio rerio)
BLVRA:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Detoxification of Reactive Oxygen Species (Danio rerio)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Danio rerio)
2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol] (Danio rerio)
2xHC-SOD1:Zn2+:Cu2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Response to metal ions (Danio rerio)
Metallothioneins bind metals (Danio rerio)
MT1A binds zinc (Danio rerio)
Zn2+ [cytosol]
MT1A:7Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
MT3 binds zinc (Danio rerio)
Zn2+ [cytosol]
MT3:7Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
MT3 exchanges zinc for copper (Danio rerio)
Zn2+ [cytosol]
MT3:4Zn2+:4Cu+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
MT3:7Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Drug ADME (Danio rerio)
Abacavir ADME (Danio rerio)
Abacavir metabolism (Danio rerio)
abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Danio rerio)
ADH1A:2Zn2+ dimer [cytosol] (Danio rerio)
Zn2+ [cytosol]
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Danio rerio)
ADAL:Zn [cytosol] (Danio rerio)
Zn2+ [cytosol]
Immune System (Danio rerio)
Innate Immune System (Danio rerio)
Antimicrobial peptides (Danio rerio)
Ion influx/efflux at host-pathogen interface (Danio rerio)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Danio rerio)
Divalent metals transported by NRAMP1 [cytosol]
Zn2+ [cytosol]
ROS and RNS production in phagocytes (Danio rerio)
NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Danio rerio)
Divalent metals transported by NRAMP1 [cytosol]
Zn2+ [cytosol]
Metabolism (Danio rerio)
Aerobic respiration and respiratory electron transport (Danio rerio)
Pyruvate metabolism (Danio rerio)
GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Danio rerio)
GLO1 dimer:2xZn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Danio rerio)
HAGH-2:2xZn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Biological oxidations (Danio rerio)
Aflatoxin activation and detoxification (Danio rerio)
ACY3:Zn2+ dimer hydrolyses mercapturic acids (Danio rerio)
ACY3:Zn2+ dimer [cytosol] (Danio rerio)
Zn2+ [cytosol]
Phase I - Functionalization of compounds (Danio rerio)
Ethanol oxidation (Danio rerio)
ADH5 oxidises S-HMGSH to S-FGSH (Danio rerio)
ADH5:2xZn2+ dimer [cytosol] (Danio rerio)
ADH5:2xZn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
ethanol + NAD+ => acetaldehyde + NADH + H+ (Danio rerio)
alcohol dehydrogenase complex [cytosol] (Danio rerio)
ADH1A:2Zn2+ dimer [cytosol] (Danio rerio)
Zn2+ [cytosol]
ADH4:2Zn2+ dimer [cytosol] (Danio rerio)
Zn2+ [cytosol]
ADH7:2Zn2+ dimer [cytosol] (Danio rerio)
Zn2+ [cytosol]
alcohol dehydrogenase 1 (class I), alpha/beta dimer [cytosol] (Danio rerio)
Zn2+ [cytosol]
alcohol dehydrogenase 6 (class V) complex [cytosol] (Danio rerio)
Zn2+ [cytosol]
Metabolism of amino acids and derivatives (Danio rerio)
Aspartate and asparagine metabolism (Danio rerio)
ASPA deacetylates NAA to acetate and L-aspartate (Danio rerio)
ASPA:Zn2+ dimer [cytosol] (Danio rerio)
ASPA:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Choline catabolism (Danio rerio)
BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Danio rerio)
BHMT:Zn2+ tetramer [cytosol] (Danio rerio)
BHMT:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Sulfur amino acid metabolism (Danio rerio)
BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Danio rerio)
BHMT:Zn2+ tetramer [cytosol] (Danio rerio)
BHMT:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Danio rerio)
BHMT2:Zn2+ tetramer [cytosol] (Danio rerio)
BHMT2:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Metabolism of lipids (Danio rerio)
Biosynthesis of specialized proresolving mediators (SPMs) (Danio rerio)
Biosynthesis of DHA-derived SPMs (Danio rerio)
Biosynthesis of D-series resolvins (Danio rerio)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Danio rerio)
LTA4H:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Danio rerio)
LTA4H:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Danio rerio)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Danio rerio)
LTA4H:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Danio rerio)
LTA4H:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Biosynthesis of protectins (Danio rerio)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Danio rerio)
LTA4H:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Danio rerio)
LTA4H:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Biosynthesis of EPA-derived SPMs (Danio rerio)
Biosynthesis of E-series 18(R)-resolvins (Danio rerio)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Danio rerio)
LTA4H:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Danio rerio)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Danio rerio)
LTA4H:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Fatty acid metabolism (Danio rerio)
Arachidonate metabolism (Danio rerio)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Danio rerio)
LTA4 is hydolysed to LTB4 by LTA4H (Danio rerio)
LTA4H:Zn2+ [cytosol] (Danio rerio)
Zn2+ [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Danio rerio)
NOSTRIN mediated eNOS trafficking (Danio rerio)
NOSTRIN mediated translocation of eNOS from plasma membrane (Danio rerio)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Danio rerio)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Danio rerio)
Zn2+ [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Danio rerio)
Zn2+ [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Danio rerio)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Danio rerio)
Zn2+ [cytosol]
![Zn2+ [cytosol] icon](/icon/R-ICO-013542.svg){kind=icon}