Reactome | ESTG [extracellular region]

ESTG [extracellular region]

Stable Identifier

R-ALL-374146

Type

Chemical Compound [SimpleEntity]

Compartment

extracellular region

Synonyms

estrogen

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Locations in the PathwayBrowser

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Signal Transduction (Gallus gallus)

- Signaling by GPCR (Gallus gallus)
  - GPCR downstream signalling (Gallus gallus)
    - G alpha (i) signalling events (Gallus gallus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
        
        GPER1:ESTG [plasma membrane] (Gallus gallus)
        
        ESTG [extracellular region]
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
        
        GPER1:ESTG [plasma membrane] (Gallus gallus)
        
        ESTG [extracellular region]
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
        
        GPER1:ESTG [plasma membrane] (Gallus gallus)
        
        ESTG [extracellular region]
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
        
        GPER1:ESTG [plasma membrane] (Gallus gallus)
        
        ESTG [extracellular region]
      - The Ligand:GPCR:Gi complex dissociates (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
        
        GPER1:ESTG [plasma membrane] (Gallus gallus)
        
        ESTG [extracellular region]
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
        
        GPER1:ESTG [plasma membrane] (Gallus gallus)
        
        ESTG [extracellular region]
  - GPCR ligand binding (Gallus gallus)
    - Class A/1 (Rhodopsin-like receptors) (Gallus gallus)
      - Peptide ligand-binding receptors (Gallus gallus)
        
        G protein-coupled estrogen receptor 1 binds estrogen non-classically (Gallus gallus)
        
        ESTG [extracellular region]
        
        GPER1:ESTG [plasma membrane] (Gallus gallus)
        
        ESTG [extracellular region]
- Signaling by Nuclear Receptors (Gallus gallus)
  - ESR-mediated signaling (Gallus gallus)
    - Extra-nuclear estrogen signaling (Gallus gallus)
      - PTK2 is recruited to methylated ESR1 (Gallus gallus)
        
        Me260-ESR1:STRN:ESTG: MyrG-pY419 SRC:PI3Kalpha:pY-PTK2 [plasma membrane] (Gallus gallus)
        
        Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Gallus gallus)
        
        ESTG:Me260-ESR1 dimer [cytosol] (Gallus gallus)
        
        ESTG [extracellular region]
        
        Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Gallus gallus)
        
        ESTG:Me260-ESR1 dimer [cytosol] (Gallus gallus)
        
        ESTG [extracellular region]

External Reference Information

External Reference

estrogen [ChEBI:50114]

Participant Of

hasComponent

input

This entity regulates

Positively

PRMT1 methylates ESRs

Other forms of this molecule

ESTG [nucleoplasm]

ESTG [cytosol]

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