Reactome | Cu2+ [mitochondrial intermembrane space]

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Cu2+ [mitochondrial intermembrane space]

Stable Identifier

R-ALL-3777113

Type

Chemical Compound [SimpleEntity]

Compartment

mitochondrial intermembrane space

Synonyms

Copper, copper(2+)

Locations in the PathwayBrowser

for Species:

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Cellular responses to external stimuli (Bos taurus)

- Cellular responses to stress (Bos taurus)
  - Detoxification of Reactive Oxygen Species (Bos taurus)
    - SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Bos taurus)
      - SOD1 dimer [mitochondrial intermembrane space] (Bos taurus)
        
        SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space] (Bos taurus)
        
        Cu2+ [mitochondrial intermembrane space]

Cellular responses to external stimuli (Caenorhabditis elegans)

- Cellular responses to stress (Caenorhabditis elegans)
  - Detoxification of Reactive Oxygen Species (Caenorhabditis elegans)
    - SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Caenorhabditis elegans)
      - SOD1 dimer [mitochondrial intermembrane space] (Caenorhabditis elegans)
        
        SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space] (Caenorhabditis elegans)
        
        Cu2+ [mitochondrial intermembrane space]

Cellular responses to external stimuli (Canis familiaris)

- Cellular responses to stress (Canis familiaris)
  - Detoxification of Reactive Oxygen Species (Canis familiaris)
    - SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Canis familiaris)
      - SOD1 dimer [mitochondrial intermembrane space] (Canis familiaris)
        
        SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space] (Canis familiaris)
        
        Cu2+ [mitochondrial intermembrane space]

Cellular responses to external stimuli (Danio rerio)

- Cellular responses to stress (Danio rerio)
  - Detoxification of Reactive Oxygen Species (Danio rerio)
    - SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Danio rerio)
      - SOD1 dimer [mitochondrial intermembrane space] (Danio rerio)
        
        SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space] (Danio rerio)
        
        Cu2+ [mitochondrial intermembrane space]

Cellular responses to external stimuli (Dictyostelium discoideum)

- Cellular responses to stress (Dictyostelium discoideum)
  - Detoxification of Reactive Oxygen Species (Dictyostelium discoideum)
    - SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Dictyostelium discoideum)
      - SOD1 dimer [mitochondrial intermembrane space] (Dictyostelium discoideum)
        
        SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space] (Dictyostelium discoideum)
        
        Cu2+ [mitochondrial intermembrane space]

Cellular responses to external stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - Detoxification of Reactive Oxygen Species (Drosophila melanogaster)
    - SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Drosophila melanogaster)
      - SOD1 dimer [mitochondrial intermembrane space] (Drosophila melanogaster)
        
        SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space] (Drosophila melanogaster)
        
        Cu2+ [mitochondrial intermembrane space]

Cellular responses to external stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Detoxification of Reactive Oxygen Species (Homo sapiens)
    - CCS transfers Cu to SOD1 (mitochondrial) (Homo sapiens)
      - SOD1 dimer [mitochondrial intermembrane space] (Homo sapiens)
        
        SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space] (Homo sapiens)
        
        Cu2+ [mitochondrial intermembrane space]
    - SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Homo sapiens)
      - SOD1 dimer [mitochondrial intermembrane space] (Homo sapiens)
        
        SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space] (Homo sapiens)
        
        Cu2+ [mitochondrial intermembrane space]

Cellular responses to external stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Detoxification of Reactive Oxygen Species (Mus musculus)
    - SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Mus musculus)
      - SOD1 dimer [mitochondrial intermembrane space] (Mus musculus)
        
        SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space] (Mus musculus)
        
        Cu2+ [mitochondrial intermembrane space]

Cellular responses to external stimuli (Rattus norvegicus)

- Cellular responses to stress (Rattus norvegicus)
  - Detoxification of Reactive Oxygen Species (Rattus norvegicus)
    - SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Rattus norvegicus)
      - SOD1 dimer [mitochondrial intermembrane space] (Rattus norvegicus)
        
        SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space] (Rattus norvegicus)
        
        Cu2+ [mitochondrial intermembrane space]

Cellular responses to external stimuli (Saccharomyces cerevisiae)

- Cellular responses to stress (Saccharomyces cerevisiae)
  - Detoxification of Reactive Oxygen Species (Saccharomyces cerevisiae)
    - SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Saccharomyces cerevisiae)
      - SOD1 dimer [mitochondrial intermembrane space] (Saccharomyces cerevisiae)
        
        SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space] (Saccharomyces cerevisiae)
        
        Cu2+ [mitochondrial intermembrane space]

Cellular responses to external stimuli (Schizosaccharomyces pombe)

- Cellular responses to stress (Schizosaccharomyces pombe)
  - Detoxification of Reactive Oxygen Species (Schizosaccharomyces pombe)
    - SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Schizosaccharomyces pombe)
      - SOD1 dimer [mitochondrial intermembrane space] (Schizosaccharomyces pombe)
        
        SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space] (Schizosaccharomyces pombe)
        
        Cu2+ [mitochondrial intermembrane space]

Cellular responses to external stimuli (Sus scrofa)

- Cellular responses to stress (Sus scrofa)
  - Detoxification of Reactive Oxygen Species (Sus scrofa)
    - SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Sus scrofa)
      - SOD1 dimer [mitochondrial intermembrane space] (Sus scrofa)
        
        SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space] (Sus scrofa)
        
        Cu2+ [mitochondrial intermembrane space]

Cellular responses to external stimuli (Xenopus tropicalis)

- Cellular responses to stress (Xenopus tropicalis)
  - Detoxification of Reactive Oxygen Species (Xenopus tropicalis)
    - SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Xenopus tropicalis)
      - SOD1 dimer [mitochondrial intermembrane space] (Xenopus tropicalis)
        
        SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space] (Xenopus tropicalis)
        
        Cu2+ [mitochondrial intermembrane space]

External Reference Information

External Reference

copper(2+) [ChEBI:29036]

Participant Of

hasComponent

2xHC-Sod1:Zn2+:Cu2+ [mitochondrial intermembrane space]
SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space]
SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space]
SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space]
SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space]
SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space]
SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space]
SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space]
SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space]
SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space]
SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space]
SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space]
SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space]
SOD1:Zn2+:Cu2+ [mitochondrial intermembrane space]

Other forms of this molecule

Cu2+ [melanosome membrane]

Cu2+ [Golgi lumen]

Cu2+ [extracellular region]

Cu2+ [cytosol]

Cross References

COMPOUND

C00070

HMDB Metabolite

HMDB0000657

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