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PYR [extracellular region]
Stable Identifier
R-ALL-429750
Type
Chemical Compound [SimpleEntity]
Compartment
extracellular region
Synonyms
Pyruvate, pyruvic acid, 2-Oxopropanoate, 2-Oxopropanoic acid, Pyroracemic acid
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Drug ADME (Bos taurus)
Aspirin ADME (Bos taurus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Bos taurus)
MCT substrates [extracellular region]
PYR [extracellular region]
Metabolism (Bos taurus)
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Nicotinate metabolism (Bos taurus)
Nicotinamide salvaging (Bos taurus)
SLC5A8 transports monocarboxylates from extracellular region to cytosol (Bos taurus)
monocarboxylates transported by SLC5A8 [extracellular region]
PYR [extracellular region]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
Proton-coupled monocarboxylate transport (Bos taurus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Bos taurus)
MCT substrates [extracellular region]
PYR [extracellular region]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Bos taurus)
MCT substrates [extracellular region]
PYR [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Bos taurus)
Multifunctional anion exchangers (Bos taurus)
SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Bos taurus)
LACT, PYR, NCA [extracellular region]
PYR [extracellular region]
Organic anion transporters (Bos taurus)
SLC5A8 transports monocarboxylates from extracellular region to cytosol (Bos taurus)
monocarboxylates transported by SLC5A8 [extracellular region]
PYR [extracellular region]
Drug ADME (Caenorhabditis elegans)
Aspirin ADME (Caenorhabditis elegans)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Caenorhabditis elegans)
MCT substrates [extracellular region]
PYR [extracellular region]
Metabolism (Caenorhabditis elegans)
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Nicotinate metabolism (Caenorhabditis elegans)
Nicotinamide salvaging (Caenorhabditis elegans)
SLC5A8 transports monocarboxylates from extracellular region to cytosol (Caenorhabditis elegans)
monocarboxylates transported by SLC5A8 [extracellular region]
PYR [extracellular region]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of bile salts and organic acids, metal ions and amine compounds (Caenorhabditis elegans)
Proton-coupled monocarboxylate transport (Caenorhabditis elegans)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Caenorhabditis elegans)
MCT substrates [extracellular region]
PYR [extracellular region]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Caenorhabditis elegans)
MCT substrates [extracellular region]
PYR [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Caenorhabditis elegans)
Multifunctional anion exchangers (Caenorhabditis elegans)
SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Caenorhabditis elegans)
LACT, PYR, NCA [extracellular region]
PYR [extracellular region]
Organic anion transporters (Caenorhabditis elegans)
SLC5A8 transports monocarboxylates from extracellular region to cytosol (Caenorhabditis elegans)
monocarboxylates transported by SLC5A8 [extracellular region]
PYR [extracellular region]
Drug ADME (Canis familiaris)
Aspirin ADME (Canis familiaris)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Canis familiaris)
MCT substrates [extracellular region]
PYR [extracellular region]
Metabolism (Canis familiaris)
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Nicotinate metabolism (Canis familiaris)
Nicotinamide salvaging (Canis familiaris)
SLC5A8 transports monocarboxylates from extracellular region to cytosol (Canis familiaris)
monocarboxylates transported by SLC5A8 [extracellular region]
PYR [extracellular region]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
Proton-coupled monocarboxylate transport (Canis familiaris)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Canis familiaris)
MCT substrates [extracellular region]
PYR [extracellular region]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Canis familiaris)
MCT substrates [extracellular region]
PYR [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Canis familiaris)
Multifunctional anion exchangers (Canis familiaris)
SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Canis familiaris)
LACT, PYR, NCA [extracellular region]
PYR [extracellular region]
Organic anion transporters (Canis familiaris)
SLC5A8 transports monocarboxylates from extracellular region to cytosol (Canis familiaris)
monocarboxylates transported by SLC5A8 [extracellular region]
PYR [extracellular region]
Metabolism (Danio rerio)
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Nicotinate metabolism (Danio rerio)
Nicotinamide salvaging (Danio rerio)
SLC5A8 transports monocarboxylates from extracellular region to cytosol (Danio rerio)
monocarboxylates transported by SLC5A8 [extracellular region]
PYR [extracellular region]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
Proton-coupled monocarboxylate transport (Danio rerio)
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Danio rerio)
MCT substrates [extracellular region]
PYR [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Danio rerio)
Multifunctional anion exchangers (Danio rerio)
SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Danio rerio)
LACT, PYR, NCA [extracellular region]
PYR [extracellular region]
Organic anion transporters (Danio rerio)
SLC5A8 transports monocarboxylates from extracellular region to cytosol (Danio rerio)
monocarboxylates transported by SLC5A8 [extracellular region]
PYR [extracellular region]
Drug ADME (Drosophila melanogaster)
Aspirin ADME (Drosophila melanogaster)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Drosophila melanogaster)
MCT substrates [extracellular region]
PYR [extracellular region]
Metabolism (Drosophila melanogaster)
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of water-soluble vitamins and cofactors (Drosophila melanogaster)
Nicotinate metabolism (Drosophila melanogaster)
Nicotinamide salvaging (Drosophila melanogaster)
SLC5A8 transports monocarboxylates from extracellular region to cytosol (Drosophila melanogaster)
monocarboxylates transported by SLC5A8 [extracellular region]
PYR [extracellular region]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of bile salts and organic acids, metal ions and amine compounds (Drosophila melanogaster)
Proton-coupled monocarboxylate transport (Drosophila melanogaster)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Drosophila melanogaster)
MCT substrates [extracellular region]
PYR [extracellular region]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Drosophila melanogaster)
MCT substrates [extracellular region]
PYR [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Drosophila melanogaster)
Multifunctional anion exchangers (Drosophila melanogaster)
SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Drosophila melanogaster)
LACT, PYR, NCA [extracellular region]
PYR [extracellular region]
Organic anion transporters (Drosophila melanogaster)
SLC5A8 transports monocarboxylates from extracellular region to cytosol (Drosophila melanogaster)
monocarboxylates transported by SLC5A8 [extracellular region]
PYR [extracellular region]
Drug ADME (Gallus gallus)
Aspirin ADME (Gallus gallus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Gallus gallus)
MCT substrates [extracellular region]
PYR [extracellular region]
Metabolism (Gallus gallus)
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of water-soluble vitamins and cofactors (Gallus gallus)
Nicotinate metabolism (Gallus gallus)
Nicotinamide salvaging (Gallus gallus)
SLC5A8 transports monocarboxylates from extracellular region to cytosol (Gallus gallus)
monocarboxylates transported by SLC5A8 [extracellular region]
PYR [extracellular region]
Transport of small molecules (Gallus gallus)
SLC-mediated transmembrane transport (Gallus gallus)
Transport of bile salts and organic acids, metal ions and amine compounds (Gallus gallus)
Proton-coupled monocarboxylate transport (Gallus gallus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Gallus gallus)
MCT substrates [extracellular region]
PYR [extracellular region]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Gallus gallus)
MCT substrates [extracellular region]
PYR [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Gallus gallus)
Multifunctional anion exchangers (Gallus gallus)
SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Gallus gallus)
LACT, PYR, NCA [extracellular region]
PYR [extracellular region]
Organic anion transporters (Gallus gallus)
SLC5A8 transports monocarboxylates from extracellular region to cytosol (Gallus gallus)
monocarboxylates transported by SLC5A8 [extracellular region]
PYR [extracellular region]
Disease (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
SLC transporter disorders (Homo sapiens)
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) (Homo sapiens)
Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)
MCT substrates [extracellular region]
PYR [extracellular region]
Drug ADME (Homo sapiens)
Aspirin ADME (Homo sapiens)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)
MCT substrates [extracellular region]
PYR [extracellular region]
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Nicotinate metabolism (Homo sapiens)
Nicotinamide salvaging (Homo sapiens)
SLC5A8 transports monocarboxylates from extracellular region to cytosol (Homo sapiens)
monocarboxylates transported by SLC5A8 [extracellular region]
PYR [extracellular region]
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Proton-coupled monocarboxylate transport (Homo sapiens)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)
MCT substrates [extracellular region]
PYR [extracellular region]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)
MCT substrates [extracellular region]
PYR [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Multifunctional anion exchangers (Homo sapiens)
SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Homo sapiens)
LACT, PYR, NCA [extracellular region]
PYR [extracellular region]
Organic anion transporters (Homo sapiens)
SLC5A8 transports monocarboxylates from extracellular region to cytosol (Homo sapiens)
monocarboxylates transported by SLC5A8 [extracellular region]
PYR [extracellular region]
Drug ADME (Mus musculus)
Aspirin ADME (Mus musculus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Mus musculus)
MCT substrates [extracellular region]
PYR [extracellular region]
Metabolism (Mus musculus)
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of water-soluble vitamins and cofactors (Mus musculus)
Nicotinate metabolism (Mus musculus)
Nicotinamide salvaging (Mus musculus)
SLC5A8 transports monocarboxylates from extracellular region to cytosol (Mus musculus)
monocarboxylates transported by SLC5A8 [extracellular region]
PYR [extracellular region]
Transport of small molecules (Mus musculus)
SLC-mediated transmembrane transport (Mus musculus)
Transport of bile salts and organic acids, metal ions and amine compounds (Mus musculus)
Proton-coupled monocarboxylate transport (Mus musculus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Mus musculus)
MCT substrates [extracellular region]
PYR [extracellular region]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Mus musculus)
MCT substrates [extracellular region]
PYR [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Mus musculus)
Multifunctional anion exchangers (Mus musculus)
SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Mus musculus)
LACT, PYR, NCA [extracellular region]
PYR [extracellular region]
Organic anion transporters (Mus musculus)
SLC5A8 transports monocarboxylates from extracellular region to cytosol (Mus musculus)
monocarboxylates transported by SLC5A8 [extracellular region]
PYR [extracellular region]
Drug ADME (Rattus norvegicus)
Aspirin ADME (Rattus norvegicus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Rattus norvegicus)
MCT substrates [extracellular region]
PYR [extracellular region]
Metabolism (Rattus norvegicus)
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of water-soluble vitamins and cofactors (Rattus norvegicus)
Nicotinate metabolism (Rattus norvegicus)
Nicotinamide salvaging (Rattus norvegicus)
SLC5A8 transports monocarboxylates from extracellular region to cytosol (Rattus norvegicus)
monocarboxylates transported by SLC5A8 [extracellular region]
PYR [extracellular region]
Transport of small molecules (Rattus norvegicus)
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of bile salts and organic acids, metal ions and amine compounds (Rattus norvegicus)
Proton-coupled monocarboxylate transport (Rattus norvegicus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Rattus norvegicus)
MCT substrates [extracellular region]
PYR [extracellular region]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Rattus norvegicus)
MCT substrates [extracellular region]
PYR [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Rattus norvegicus)
Multifunctional anion exchangers (Rattus norvegicus)
SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Rattus norvegicus)
LACT, PYR, NCA [extracellular region]
PYR [extracellular region]
Organic anion transporters (Rattus norvegicus)
SLC5A8 transports monocarboxylates from extracellular region to cytosol (Rattus norvegicus)
monocarboxylates transported by SLC5A8 [extracellular region]
PYR [extracellular region]
Drug ADME (Sus scrofa)
Aspirin ADME (Sus scrofa)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Sus scrofa)
MCT substrates [extracellular region]
PYR [extracellular region]
Metabolism (Sus scrofa)
Metabolism of vitamins and cofactors (Sus scrofa)
Metabolism of water-soluble vitamins and cofactors (Sus scrofa)
Nicotinate metabolism (Sus scrofa)
Nicotinamide salvaging (Sus scrofa)
SLC5A8 transports monocarboxylates from extracellular region to cytosol (Sus scrofa)
monocarboxylates transported by SLC5A8 [extracellular region]
PYR [extracellular region]
Transport of small molecules (Sus scrofa)
SLC-mediated transmembrane transport (Sus scrofa)
Transport of bile salts and organic acids, metal ions and amine compounds (Sus scrofa)
Proton-coupled monocarboxylate transport (Sus scrofa)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Sus scrofa)
MCT substrates [extracellular region]
PYR [extracellular region]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Sus scrofa)
MCT substrates [extracellular region]
PYR [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Sus scrofa)
Multifunctional anion exchangers (Sus scrofa)
SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Sus scrofa)
LACT, PYR, NCA [extracellular region]
PYR [extracellular region]
Organic anion transporters (Sus scrofa)
SLC5A8 transports monocarboxylates from extracellular region to cytosol (Sus scrofa)
monocarboxylates transported by SLC5A8 [extracellular region]
PYR [extracellular region]
Drug ADME (Xenopus tropicalis)
Aspirin ADME (Xenopus tropicalis)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Xenopus tropicalis)
MCT substrates [extracellular region]
PYR [extracellular region]
Metabolism (Xenopus tropicalis)
Metabolism of vitamins and cofactors (Xenopus tropicalis)
Metabolism of water-soluble vitamins and cofactors (Xenopus tropicalis)
Nicotinate metabolism (Xenopus tropicalis)
Nicotinamide salvaging (Xenopus tropicalis)
SLC5A8 transports monocarboxylates from extracellular region to cytosol (Xenopus tropicalis)
monocarboxylates transported by SLC5A8 [extracellular region]
PYR [extracellular region]
Transport of small molecules (Xenopus tropicalis)
SLC-mediated transmembrane transport (Xenopus tropicalis)
Transport of bile salts and organic acids, metal ions and amine compounds (Xenopus tropicalis)
Proton-coupled monocarboxylate transport (Xenopus tropicalis)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Xenopus tropicalis)
MCT substrates [extracellular region]
PYR [extracellular region]
Transport of inorganic cations/anions and amino acids/oligopeptides (Xenopus tropicalis)
Multifunctional anion exchangers (Xenopus tropicalis)
SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Xenopus tropicalis)
LACT, PYR, NCA [extracellular region]
PYR [extracellular region]
Organic anion transporters (Xenopus tropicalis)
SLC5A8 transports monocarboxylates from extracellular region to cytosol (Xenopus tropicalis)
monocarboxylates transported by SLC5A8 [extracellular region]
PYR [extracellular region]
External Reference Information
External Reference
pyruvate [ChEBI:15361]
Participates
as a member of
MCT substrates [extracellular region]
LACT, PYR, NCA [extracellular region]
monocarboxylates transported by SLC5A8 [extracellular region]
Other forms of this molecule
PYR [cytoplasm]
pyruvic acid [cytosol]
PYR [peroxisomal matrix]
PYR [cytosol]
PYR [mitochondrial intermembrane space]
PYR [mitochondrial matrix]
Cross References
KNApSAcK
C00001200
AraCyc
PYRUVATE
CAS
127-17-3
COMPOUND
C00022
PubChem Compound
107735
UMBBD
c0159
ZINC
000001532517
KEGG Gene
C00022
,
c00022
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![PYR [extracellular region] icon](/icon/R-ICO-013265.svg){kind=icon}
