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About
What is Reactome ?
News
Team
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Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
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heme [cytosol]
Stable Identifier
R-ALL-71185
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
heme, ferroheme b, heme (ferrous)
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to external stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Detoxification of Reactive Oxygen Species (Bos taurus)
NOX2 generates superoxide from oxygen (Bos taurus)
NOX2 complex [phagocytic vesicle membrane] (Bos taurus)
Cytochrome b-245 [phagocytic vesicle membrane] (Bos taurus)
heme [cytosol]
Metabolism (Bos taurus)
Metabolism of amino acids and derivatives (Bos taurus)
Sulfur amino acid metabolism (Bos taurus)
Cysteine formation from homocysteine (Bos taurus)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Bos taurus)
PXLP-CBS tetramers [cytosol] (Bos taurus)
PXLP-K119-CBS tetramer [cytosol] (Bos taurus)
heme [cytosol]
PXLP-K119-CBSL tetramer [cytosol] (Bos taurus)
heme [cytosol]
Tryptophan catabolism (Bos taurus)
IDO1 dioxygenates L-Trp to NFK (Bos taurus)
IDO1 [cytosol] (Bos taurus)
heme [cytosol]
IDO2 dioxygenates L-Trp to NFK (Bos taurus)
IDO2 [cytosol] (Bos taurus)
heme [cytosol]
TDO tetramer dioxygenates L-Trp to NFK (Bos taurus)
TDO2 tetramer [cytosol] (Bos taurus)
heme [cytosol]
Metabolism of nitric oxide: eNOS activation and regulation (Bos taurus)
NOSTRIN mediated eNOS trafficking (Bos taurus)
NOSTRIN mediated translocation of eNOS from plasma membrane (Bos taurus)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Bos taurus)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Bos taurus)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Bos taurus)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
heme [cytosol]
eNOS activation (Bos taurus)
CYGB binds O2 (Bos taurus)
CYGB dimer [cytosol] (Bos taurus)
CYGB:heme [cytosol] (Bos taurus)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Bos taurus)
CYGB dimer [cytosol] (Bos taurus)
CYGB:heme [cytosol] (Bos taurus)
heme [cytosol]
CYGB dioxygenates NO (Bos taurus)
CYGB dimer [cytosol] (Bos taurus)
CYGB:heme [cytosol] (Bos taurus)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Bos taurus)
CYGB dimer [cytosol] (Bos taurus)
CYGB:heme [cytosol] (Bos taurus)
heme [cytosol]
Metabolism of porphyrins (Bos taurus)
Heme biosynthesis (Bos taurus)
FLVCR1-1 transports heme from cytosol to extracellular region (Bos taurus)
heme [cytosol]
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Bos taurus)
heme [cytosol]
Heme degradation (Bos taurus)
HMOX1,2 cleave heme (Bos taurus)
heme [cytosol]
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
heme [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
heme [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Bos taurus)
NOX2 complex:RAC1:GTP [plasma membrane] (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
heme [cytosol]
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases Activate NADPH Oxidases (Bos taurus)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
heme [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
heme [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Bos taurus)
NOX2 complex:RAC1:GTP [plasma membrane] (Bos taurus)
NOX2 complex [plasma membrane] (Bos taurus)
Cytochrome b-245 [plasma membrane] (Bos taurus)
heme [cytosol]
Transport of small molecules (Bos taurus)
ABC-family proteins mediated transport (Bos taurus)
Mitochondrial ABC transporters (Bos taurus)
ABC7, mABC1 and mABC2 mediate heme transport (Bos taurus)
heme [cytosol]
Intracellular oxygen transport (Bos taurus)
CYGB binds O2 (Bos taurus)
CYGB dimer [cytosol] (Bos taurus)
CYGB:heme [cytosol] (Bos taurus)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Bos taurus)
CYGB dimer [cytosol] (Bos taurus)
CYGB:heme [cytosol] (Bos taurus)
heme [cytosol]
CYGB:O2 dissociates (Bos taurus)
CYGB dimer [cytosol] (Bos taurus)
CYGB:heme [cytosol] (Bos taurus)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Bos taurus)
CYGB dimer [cytosol] (Bos taurus)
CYGB:heme [cytosol] (Bos taurus)
heme [cytosol]
Myoglobin binds oxygen (Bos taurus)
MB:ferroheme b [cytosol] (Bos taurus)
heme [cytosol]
MB:ferroheme b:O2 [cytosol] (Bos taurus)
MB:ferroheme b [cytosol] (Bos taurus)
heme [cytosol]
Myoglobin:oxygen dissociates (Bos taurus)
MB:ferroheme b [cytosol] (Bos taurus)
heme [cytosol]
MB:ferroheme b:O2 [cytosol] (Bos taurus)
MB:ferroheme b [cytosol] (Bos taurus)
heme [cytosol]
Neuroglobin binds oxygen (Bos taurus)
NGB:ferroheme b [cytosol] (Bos taurus)
heme [cytosol]
NGB:ferroheme b:O2 [cytosol] (Bos taurus)
NGB:ferroheme b [cytosol] (Bos taurus)
heme [cytosol]
Neuroglobin:oxygen dissociates (Bos taurus)
NGB:ferroheme b [cytosol] (Bos taurus)
heme [cytosol]
NGB:ferroheme b:O2 [cytosol] (Bos taurus)
NGB:ferroheme b [cytosol] (Bos taurus)
heme [cytosol]
Iron uptake and transport (Bos taurus)
FLVCR1-1 transports heme from cytosol to extracellular region (Bos taurus)
heme [cytosol]
HMOX1,2 cleave heme (Bos taurus)
heme [cytosol]
O2/CO2 exchange in erythrocytes (Bos taurus)
Erythrocytes take up carbon dioxide and release oxygen (Bos taurus)
CYB5Rs reduce MetHb to HbA (Bos taurus)
HbA [cytosol] (Bos taurus)
Hemoglobin alpha:ferroheme b [cytosol] (Bos taurus)
heme [cytosol]
Hemoglobin beta:ferroheme b [cytosol] (Bos taurus)
heme [cytosol]
Hemoglobin A is protonated and carbamated causing release of oxygen (Bos taurus)
OxyHbA [cytosol] (Bos taurus)
Hemoglobin alpha:ferroheme b:oxygen [cytosol] (Bos taurus)
heme [cytosol]
Hemoglobin beta:ferroheme b:oxygen [cytosol] (Bos taurus)
heme [cytosol]
Protonated Carbamino DeoxyHbA [cytosol] (Bos taurus)
Protonated Carbamino Hemoglobin alpha:ferroheme b [cytosol] (Bos taurus)
heme [cytosol]
Protonated Carbamino Hemoglobin beta: ferroheme b [cytosol] (Bos taurus)
heme [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Bos taurus)
Hemoglobin A binds oxygen and releases protons and carbon dioxide (Bos taurus)
OxyHbA [cytosol] (Bos taurus)
Hemoglobin alpha:ferroheme b:oxygen [cytosol] (Bos taurus)
heme [cytosol]
Hemoglobin beta:ferroheme b:oxygen [cytosol] (Bos taurus)
heme [cytosol]
Protonated Carbamino DeoxyHbA [cytosol] (Bos taurus)
Protonated Carbamino Hemoglobin alpha:ferroheme b [cytosol] (Bos taurus)
heme [cytosol]
Protonated Carbamino Hemoglobin beta: ferroheme b [cytosol] (Bos taurus)
heme [cytosol]
Metabolism (Caenorhabditis elegans)
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Sulfur amino acid metabolism (Caenorhabditis elegans)
Cysteine formation from homocysteine (Caenorhabditis elegans)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Caenorhabditis elegans)
PXLP-CBS tetramers [cytosol] (Caenorhabditis elegans)
PXLP-K119-CBS tetramer [cytosol] (Caenorhabditis elegans)
heme [cytosol]
PXLP-K119-CBSL tetramer [cytosol] (Caenorhabditis elegans)
heme [cytosol]
Tryptophan catabolism (Caenorhabditis elegans)
TDO tetramer dioxygenates L-Trp to NFK (Caenorhabditis elegans)
TDO2 tetramer [cytosol] (Caenorhabditis elegans)
heme [cytosol]
Metabolism of nitric oxide: eNOS activation and regulation (Caenorhabditis elegans)
NOSTRIN mediated eNOS trafficking (Caenorhabditis elegans)
NOSTRIN mediated translocation of eNOS from plasma membrane (Caenorhabditis elegans)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Caenorhabditis elegans)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Caenorhabditis elegans)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Caenorhabditis elegans)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Caenorhabditis elegans)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Caenorhabditis elegans)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Caenorhabditis elegans)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Caenorhabditis elegans)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Caenorhabditis elegans)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Caenorhabditis elegans)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Caenorhabditis elegans)
heme [cytosol]
eNOS activation (Caenorhabditis elegans)
AKT1 phosphorylates eNOS (Caenorhabditis elegans)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
eNOS:CaM:HSP90 [plasma membrane] (Caenorhabditis elegans)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Caenorhabditis elegans)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
heme [cytosol]
BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
heme [cytosol]
CYGB binds O2 (Caenorhabditis elegans)
CYGB dimer [cytosol] (Caenorhabditis elegans)
CYGB:heme [cytosol] (Caenorhabditis elegans)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Caenorhabditis elegans)
CYGB dimer [cytosol] (Caenorhabditis elegans)
CYGB:heme [cytosol] (Caenorhabditis elegans)
heme [cytosol]
CYGB dioxygenates NO (Caenorhabditis elegans)
CYGB dimer [cytosol] (Caenorhabditis elegans)
CYGB:heme [cytosol] (Caenorhabditis elegans)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Caenorhabditis elegans)
CYGB dimer [cytosol] (Caenorhabditis elegans)
CYGB:heme [cytosol] (Caenorhabditis elegans)
heme [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
heme [cytosol]
Uncoupled eNOS favours the formation of superoxide (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
heme [cytosol]
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
heme [cytosol]
Metabolism of porphyrins (Caenorhabditis elegans)
Heme biosynthesis (Caenorhabditis elegans)
FLVCR1-1 transports heme from cytosol to extracellular region (Caenorhabditis elegans)
heme [cytosol]
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Caenorhabditis elegans)
heme [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of cofactors (Caenorhabditis elegans)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Caenorhabditis elegans)
BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
heme [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
heme [cytosol]
Signal Transduction (Caenorhabditis elegans)
Signaling by Nuclear Receptors (Caenorhabditis elegans)
ESR-mediated signaling (Caenorhabditis elegans)
Extra-nuclear estrogen signaling (Caenorhabditis elegans)
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
heme [cytosol]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
VEGFR2 mediated vascular permeability (Caenorhabditis elegans)
AKT1 phosphorylates eNOS (Caenorhabditis elegans)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
eNOS:CaM:HSP90 [plasma membrane] (Caenorhabditis elegans)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Caenorhabditis elegans)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
heme [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
heme [cytosol]
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
heme [cytosol]
Transport of small molecules (Caenorhabditis elegans)
ABC-family proteins mediated transport (Caenorhabditis elegans)
Mitochondrial ABC transporters (Caenorhabditis elegans)
ABC7, mABC1 and mABC2 mediate heme transport (Caenorhabditis elegans)
heme [cytosol]
Intracellular oxygen transport (Caenorhabditis elegans)
CYGB binds O2 (Caenorhabditis elegans)
CYGB dimer [cytosol] (Caenorhabditis elegans)
CYGB:heme [cytosol] (Caenorhabditis elegans)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Caenorhabditis elegans)
CYGB dimer [cytosol] (Caenorhabditis elegans)
CYGB:heme [cytosol] (Caenorhabditis elegans)
heme [cytosol]
CYGB:O2 dissociates (Caenorhabditis elegans)
CYGB dimer [cytosol] (Caenorhabditis elegans)
CYGB:heme [cytosol] (Caenorhabditis elegans)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Caenorhabditis elegans)
CYGB dimer [cytosol] (Caenorhabditis elegans)
CYGB:heme [cytosol] (Caenorhabditis elegans)
heme [cytosol]
Neuroglobin binds oxygen (Caenorhabditis elegans)
NGB:ferroheme b [cytosol] (Caenorhabditis elegans)
heme [cytosol]
NGB:ferroheme b:O2 [cytosol] (Caenorhabditis elegans)
NGB:ferroheme b [cytosol] (Caenorhabditis elegans)
heme [cytosol]
Neuroglobin:oxygen dissociates (Caenorhabditis elegans)
NGB:ferroheme b [cytosol] (Caenorhabditis elegans)
heme [cytosol]
NGB:ferroheme b:O2 [cytosol] (Caenorhabditis elegans)
NGB:ferroheme b [cytosol] (Caenorhabditis elegans)
heme [cytosol]
Iron uptake and transport (Caenorhabditis elegans)
FLVCR1-1 transports heme from cytosol to extracellular region (Caenorhabditis elegans)
heme [cytosol]
Cellular responses to external stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Detoxification of Reactive Oxygen Species (Canis familiaris)
NOX2 generates superoxide from oxygen (Canis familiaris)
NOX2 complex [phagocytic vesicle membrane] (Canis familiaris)
Cytochrome b-245 [phagocytic vesicle membrane] (Canis familiaris)
heme [cytosol]
Metabolism (Canis familiaris)
Metabolism of amino acids and derivatives (Canis familiaris)
Sulfur amino acid metabolism (Canis familiaris)
Cysteine formation from homocysteine (Canis familiaris)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Canis familiaris)
PXLP-CBS tetramers [cytosol] (Canis familiaris)
PXLP-K119-CBS tetramer [cytosol] (Canis familiaris)
heme [cytosol]
PXLP-K119-CBSL tetramer [cytosol] (Canis familiaris)
heme [cytosol]
Tryptophan catabolism (Canis familiaris)
IDO1 dioxygenates L-Trp to NFK (Canis familiaris)
IDO1 [cytosol] (Canis familiaris)
heme [cytosol]
IDO2 dioxygenates L-Trp to NFK (Canis familiaris)
IDO2 [cytosol] (Canis familiaris)
heme [cytosol]
TDO tetramer dioxygenates L-Trp to NFK (Canis familiaris)
TDO2 tetramer [cytosol] (Canis familiaris)
heme [cytosol]
Metabolism of nitric oxide: eNOS activation and regulation (Canis familiaris)
NOSTRIN mediated eNOS trafficking (Canis familiaris)
NOSTRIN mediated translocation of eNOS from plasma membrane (Canis familiaris)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Canis familiaris)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Canis familiaris)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Canis familiaris)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
heme [cytosol]
eNOS activation (Canis familiaris)
AKT1 phosphorylates eNOS (Canis familiaris)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
eNOS:CaM:HSP90 [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
heme [cytosol]
BH2 binding can lead to eNOS uncoupling (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
heme [cytosol]
CYGB binds O2 (Canis familiaris)
CYGB dimer [cytosol] (Canis familiaris)
CYGB:heme [cytosol] (Canis familiaris)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Canis familiaris)
CYGB dimer [cytosol] (Canis familiaris)
CYGB:heme [cytosol] (Canis familiaris)
heme [cytosol]
CYGB dioxygenates NO (Canis familiaris)
CYGB dimer [cytosol] (Canis familiaris)
CYGB:heme [cytosol] (Canis familiaris)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Canis familiaris)
CYGB dimer [cytosol] (Canis familiaris)
CYGB:heme [cytosol] (Canis familiaris)
heme [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
heme [cytosol]
Uncoupled eNOS favours the formation of superoxide (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
heme [cytosol]
eNOS synthesizes NO (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
heme [cytosol]
Metabolism of porphyrins (Canis familiaris)
Heme biosynthesis (Canis familiaris)
ABCG2 tetramer transports heme from cytosol to extracellular region (Canis familiaris)
heme [cytosol]
FLVCR1-1 transports heme from cytosol to extracellular region (Canis familiaris)
heme [cytosol]
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Canis familiaris)
heme [cytosol]
Heme degradation (Canis familiaris)
HMOX1,2 cleave heme (Canis familiaris)
heme [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of cofactors (Canis familiaris)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Canis familiaris)
BH2 binding can lead to eNOS uncoupling (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
heme [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
heme [cytosol]
Signal Transduction (Canis familiaris)
Signaling by Nuclear Receptors (Canis familiaris)
ESR-mediated signaling (Canis familiaris)
Extra-nuclear estrogen signaling (Canis familiaris)
eNOS synthesizes NO (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
heme [cytosol]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
NADPH oxidase 2 generates superoxide from oxygen (Canis familiaris)
NOX2 complex:RAC1:GTP [plasma membrane] (Canis familiaris)
NOX2 complex [plasma membrane] (Canis familiaris)
Cytochrome b-245 [plasma membrane] (Canis familiaris)
heme [cytosol]
VEGFR2 mediated vascular permeability (Canis familiaris)
AKT1 phosphorylates eNOS (Canis familiaris)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
eNOS:CaM:HSP90 [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
heme [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
heme [cytosol]
eNOS synthesizes NO (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Canis familiaris)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Canis familiaris)
p-S1177-eNOS dimer [plasma membrane] (Canis familiaris)
heme [cytosol]
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases Activate NADPH Oxidases (Canis familiaris)
NADPH oxidase 2 generates superoxide from oxygen (Canis familiaris)
NOX2 complex:RAC1:GTP [plasma membrane] (Canis familiaris)
NOX2 complex [plasma membrane] (Canis familiaris)
Cytochrome b-245 [plasma membrane] (Canis familiaris)
heme [cytosol]
Transport of small molecules (Canis familiaris)
ABC-family proteins mediated transport (Canis familiaris)
Mitochondrial ABC transporters (Canis familiaris)
ABC7, mABC1 and mABC2 mediate heme transport (Canis familiaris)
heme [cytosol]
Intracellular oxygen transport (Canis familiaris)
CYGB binds O2 (Canis familiaris)
CYGB dimer [cytosol] (Canis familiaris)
CYGB:heme [cytosol] (Canis familiaris)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Canis familiaris)
CYGB dimer [cytosol] (Canis familiaris)
CYGB:heme [cytosol] (Canis familiaris)
heme [cytosol]
CYGB:O2 dissociates (Canis familiaris)
CYGB dimer [cytosol] (Canis familiaris)
CYGB:heme [cytosol] (Canis familiaris)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Canis familiaris)
CYGB dimer [cytosol] (Canis familiaris)
CYGB:heme [cytosol] (Canis familiaris)
heme [cytosol]
Iron uptake and transport (Canis familiaris)
ABCG2 tetramer transports heme from cytosol to extracellular region (Canis familiaris)
heme [cytosol]
FLVCR1-1 transports heme from cytosol to extracellular region (Canis familiaris)
heme [cytosol]
HMOX1,2 cleave heme (Canis familiaris)
heme [cytosol]
O2/CO2 exchange in erythrocytes (Canis familiaris)
Erythrocytes take up carbon dioxide and release oxygen (Canis familiaris)
CYB5Rs reduce MetHb to HbA (Canis familiaris)
HbA [cytosol] (Canis familiaris)
Hemoglobin alpha:ferroheme b [cytosol] (Canis familiaris)
heme [cytosol]
Hemoglobin beta:ferroheme b [cytosol] (Canis familiaris)
heme [cytosol]
Hemoglobin A is protonated and carbamated causing release of oxygen (Canis familiaris)
OxyHbA [cytosol] (Canis familiaris)
Hemoglobin alpha:ferroheme b:oxygen [cytosol] (Canis familiaris)
heme [cytosol]
Hemoglobin beta:ferroheme b:oxygen [cytosol] (Canis familiaris)
heme [cytosol]
Protonated Carbamino DeoxyHbA [cytosol] (Canis familiaris)
Protonated Carbamino Hemoglobin alpha:ferroheme b [cytosol] (Canis familiaris)
heme [cytosol]
Protonated Carbamino Hemoglobin beta: ferroheme b [cytosol] (Canis familiaris)
heme [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Canis familiaris)
Hemoglobin A binds oxygen and releases protons and carbon dioxide (Canis familiaris)
OxyHbA [cytosol] (Canis familiaris)
Hemoglobin alpha:ferroheme b:oxygen [cytosol] (Canis familiaris)
heme [cytosol]
Hemoglobin beta:ferroheme b:oxygen [cytosol] (Canis familiaris)
heme [cytosol]
Protonated Carbamino DeoxyHbA [cytosol] (Canis familiaris)
Protonated Carbamino Hemoglobin alpha:ferroheme b [cytosol] (Canis familiaris)
heme [cytosol]
Protonated Carbamino Hemoglobin beta: ferroheme b [cytosol] (Canis familiaris)
heme [cytosol]
Cellular responses to external stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Detoxification of Reactive Oxygen Species (Danio rerio)
NOX2 generates superoxide from oxygen (Danio rerio)
NOX2 complex [phagocytic vesicle membrane] (Danio rerio)
Cytochrome b-245 [phagocytic vesicle membrane] (Danio rerio)
heme [cytosol]
Metabolism (Danio rerio)
Metabolism of amino acids and derivatives (Danio rerio)
Sulfur amino acid metabolism (Danio rerio)
Cysteine formation from homocysteine (Danio rerio)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Danio rerio)
PXLP-CBS tetramers [cytosol] (Danio rerio)
PXLP-K119-CBS tetramer [cytosol] (Danio rerio)
heme [cytosol]
PXLP-K119-CBSL tetramer [cytosol] (Danio rerio)
heme [cytosol]
Tryptophan catabolism (Danio rerio)
IDO2 dioxygenates L-Trp to NFK (Danio rerio)
IDO2 [cytosol] (Danio rerio)
heme [cytosol]
TDO tetramer dioxygenates L-Trp to NFK (Danio rerio)
TDO2 tetramer [cytosol] (Danio rerio)
heme [cytosol]
Metabolism of nitric oxide: eNOS activation and regulation (Danio rerio)
NOSTRIN mediated eNOS trafficking (Danio rerio)
NOSTRIN mediated translocation of eNOS from plasma membrane (Danio rerio)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Danio rerio)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Danio rerio)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Danio rerio)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Danio rerio)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Danio rerio)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Danio rerio)
heme [cytosol]
eNOS activation (Danio rerio)
CYGB binds O2 (Danio rerio)
CYGB dimer [cytosol] (Danio rerio)
CYGB:heme [cytosol] (Danio rerio)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Danio rerio)
CYGB dimer [cytosol] (Danio rerio)
CYGB:heme [cytosol] (Danio rerio)
heme [cytosol]
CYGB dioxygenates NO (Danio rerio)
CYGB dimer [cytosol] (Danio rerio)
CYGB:heme [cytosol] (Danio rerio)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Danio rerio)
CYGB dimer [cytosol] (Danio rerio)
CYGB:heme [cytosol] (Danio rerio)
heme [cytosol]
Metabolism of porphyrins (Danio rerio)
Heme biosynthesis (Danio rerio)
ABCG2 tetramer transports heme from cytosol to extracellular region (Danio rerio)
heme [cytosol]
FLVCR1-1 transports heme from cytosol to extracellular region (Danio rerio)
heme [cytosol]
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Danio rerio)
heme [cytosol]
Heme degradation (Danio rerio)
HMOX1,2 cleave heme (Danio rerio)
heme [cytosol]
Signal Transduction (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by VEGF (Danio rerio)
VEGFA-VEGFR2 Pathway (Danio rerio)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Danio rerio)
NOX2 complex [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Danio rerio)
heme [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Danio rerio)
NOX2 complex [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Danio rerio)
heme [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Danio rerio)
NOX2 complex:RAC1:GTP [plasma membrane] (Danio rerio)
NOX2 complex [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Danio rerio)
heme [cytosol]
Signaling by Rho GTPases (Danio rerio)
RHO GTPase Effectors (Danio rerio)
RHO GTPases Activate NADPH Oxidases (Danio rerio)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Danio rerio)
NOX2 complex [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Danio rerio)
heme [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Danio rerio)
NOX2 complex [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Danio rerio)
heme [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Danio rerio)
NOX2 complex:RAC1:GTP [plasma membrane] (Danio rerio)
NOX2 complex [plasma membrane] (Danio rerio)
Cytochrome b-245 [plasma membrane] (Danio rerio)
heme [cytosol]
Transport of small molecules (Danio rerio)
ABC-family proteins mediated transport (Danio rerio)
Mitochondrial ABC transporters (Danio rerio)
ABC7, mABC1 and mABC2 mediate heme transport (Danio rerio)
heme [cytosol]
Intracellular oxygen transport (Danio rerio)
CYGB binds O2 (Danio rerio)
CYGB dimer [cytosol] (Danio rerio)
CYGB:heme [cytosol] (Danio rerio)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Danio rerio)
CYGB dimer [cytosol] (Danio rerio)
CYGB:heme [cytosol] (Danio rerio)
heme [cytosol]
CYGB:O2 dissociates (Danio rerio)
CYGB dimer [cytosol] (Danio rerio)
CYGB:heme [cytosol] (Danio rerio)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Danio rerio)
CYGB dimer [cytosol] (Danio rerio)
CYGB:heme [cytosol] (Danio rerio)
heme [cytosol]
Myoglobin binds oxygen (Danio rerio)
MB:ferroheme b [cytosol] (Danio rerio)
heme [cytosol]
MB:ferroheme b:O2 [cytosol] (Danio rerio)
MB:ferroheme b [cytosol] (Danio rerio)
heme [cytosol]
Myoglobin:oxygen dissociates (Danio rerio)
MB:ferroheme b [cytosol] (Danio rerio)
heme [cytosol]
MB:ferroheme b:O2 [cytosol] (Danio rerio)
MB:ferroheme b [cytosol] (Danio rerio)
heme [cytosol]
Neuroglobin binds oxygen (Danio rerio)
NGB:ferroheme b [cytosol] (Danio rerio)
heme [cytosol]
NGB:ferroheme b:O2 [cytosol] (Danio rerio)
NGB:ferroheme b [cytosol] (Danio rerio)
heme [cytosol]
Neuroglobin:oxygen dissociates (Danio rerio)
NGB:ferroheme b [cytosol] (Danio rerio)
heme [cytosol]
NGB:ferroheme b:O2 [cytosol] (Danio rerio)
NGB:ferroheme b [cytosol] (Danio rerio)
heme [cytosol]
Iron uptake and transport (Danio rerio)
ABCG2 tetramer transports heme from cytosol to extracellular region (Danio rerio)
heme [cytosol]
FLVCR1-1 transports heme from cytosol to extracellular region (Danio rerio)
heme [cytosol]
HMOX1,2 cleave heme (Danio rerio)
heme [cytosol]
Metabolism (Dictyostelium discoideum)
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Sulfur amino acid metabolism (Dictyostelium discoideum)
Cysteine formation from homocysteine (Dictyostelium discoideum)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Dictyostelium discoideum)
PXLP-CBS tetramers [cytosol] (Dictyostelium discoideum)
PXLP-K119-CBS tetramer [cytosol] (Dictyostelium discoideum)
heme [cytosol]
PXLP-K119-CBSL tetramer [cytosol] (Dictyostelium discoideum)
heme [cytosol]
Tryptophan catabolism (Dictyostelium discoideum)
TDO tetramer dioxygenates L-Trp to NFK (Dictyostelium discoideum)
TDO2 tetramer [cytosol] (Dictyostelium discoideum)
heme [cytosol]
Metabolism of nitric oxide: eNOS activation and regulation (Dictyostelium discoideum)
NOSIP mediated eNOS trafficking (Dictyostelium discoideum)
eNOS binds NOSIP (Dictyostelium discoideum)
eNOS:NOSIP [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Dictyostelium discoideum)
eNOS:NOSIP [Golgi membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Dictyostelium discoideum)
heme [cytosol]
eNOS:NOSIP [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
NOSTRIN mediated eNOS trafficking (Dictyostelium discoideum)
NOSTRIN mediated translocation of eNOS from plasma membrane (Dictyostelium discoideum)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Dictyostelium discoideum)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Dictyostelium discoideum)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Dictyostelium discoideum)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
eNOS activation (Dictyostelium discoideum)
AKT1 binds eNOS complex via HSP90 (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
AKT1 phosphorylates eNOS (Dictyostelium discoideum)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
Uncoupled eNOS favours the formation of superoxide (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Dictyostelium discoideum)
myristoylated eNOS dimer [Golgi membrane] (Dictyostelium discoideum)
heme [cytosol]
myristoylated eNOS dimer [cytosol] (Dictyostelium discoideum)
heme [cytosol]
depalmitoylation of eNOS (Dictyostelium discoideum)
myristoylated eNOS dimer [cytosol] (Dictyostelium discoideum)
heme [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
eNOS synthesizes NO (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
eNOS translocation from Golgi to Caveolae (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
Metabolism of porphyrins (Dictyostelium discoideum)
Heme biosynthesis (Dictyostelium discoideum)
ABCG2 tetramer transports heme from cytosol to extracellular region (Dictyostelium discoideum)
heme [cytosol]
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of cofactors (Dictyostelium discoideum)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Dictyostelium discoideum)
BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
Signal Transduction (Dictyostelium discoideum)
Signaling by Nuclear Receptors (Dictyostelium discoideum)
ESR-mediated signaling (Dictyostelium discoideum)
Extra-nuclear estrogen signaling (Dictyostelium discoideum)
eNOS synthesizes NO (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
Signaling by Receptor Tyrosine Kinases (Dictyostelium discoideum)
Signaling by VEGF (Dictyostelium discoideum)
VEGFA-VEGFR2 Pathway (Dictyostelium discoideum)
VEGFR2 mediated vascular permeability (Dictyostelium discoideum)
AKT1 binds eNOS complex via HSP90 (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
AKT1 phosphorylates eNOS (Dictyostelium discoideum)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
eNOS synthesizes NO (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
heme [cytosol]
Transport of small molecules (Dictyostelium discoideum)
ABC-family proteins mediated transport (Dictyostelium discoideum)
Mitochondrial ABC transporters (Dictyostelium discoideum)
ABC7, mABC1 and mABC2 mediate heme transport (Dictyostelium discoideum)
heme [cytosol]
Iron uptake and transport (Dictyostelium discoideum)
ABCG2 tetramer transports heme from cytosol to extracellular region (Dictyostelium discoideum)
heme [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Sulfur amino acid metabolism (Drosophila melanogaster)
Cysteine formation from homocysteine (Drosophila melanogaster)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Drosophila melanogaster)
PXLP-CBS tetramers [cytosol] (Drosophila melanogaster)
PXLP-K119-CBS tetramer [cytosol] (Drosophila melanogaster)
heme [cytosol]
PXLP-K119-CBSL tetramer [cytosol] (Drosophila melanogaster)
heme [cytosol]
Tryptophan catabolism (Drosophila melanogaster)
TDO tetramer dioxygenates L-Trp to NFK (Drosophila melanogaster)
TDO2 tetramer [cytosol] (Drosophila melanogaster)
heme [cytosol]
Metabolism of nitric oxide: eNOS activation and regulation (Drosophila melanogaster)
NOSIP mediated eNOS trafficking (Drosophila melanogaster)
eNOS binds NOSIP (Drosophila melanogaster)
eNOS:NOSIP [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Drosophila melanogaster)
eNOS:NOSIP [Golgi membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Drosophila melanogaster)
heme [cytosol]
eNOS:NOSIP [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
NOSTRIN mediated eNOS trafficking (Drosophila melanogaster)
NOSTRIN mediated translocation of eNOS from plasma membrane (Drosophila melanogaster)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Drosophila melanogaster)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Drosophila melanogaster)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Drosophila melanogaster)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
eNOS activation (Drosophila melanogaster)
AKT1 binds eNOS complex via HSP90 (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
AKT1 phosphorylates eNOS (Drosophila melanogaster)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
BH2 binding can lead to eNOS uncoupling (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
Uncoupled eNOS favours the formation of superoxide (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Drosophila melanogaster)
myristoylated eNOS dimer [Golgi membrane] (Drosophila melanogaster)
heme [cytosol]
myristoylated eNOS dimer [cytosol] (Drosophila melanogaster)
heme [cytosol]
depalmitoylation of eNOS (Drosophila melanogaster)
myristoylated eNOS dimer [cytosol] (Drosophila melanogaster)
heme [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
eNOS synthesizes NO (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
eNOS translocation from Golgi to Caveolae (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
Metabolism of porphyrins (Drosophila melanogaster)
Heme biosynthesis (Drosophila melanogaster)
FLVCR1-1 transports heme from cytosol to extracellular region (Drosophila melanogaster)
heme [cytosol]
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Drosophila melanogaster)
heme [cytosol]
Heme degradation (Drosophila melanogaster)
HMOX1,2 cleave heme (Drosophila melanogaster)
heme [cytosol]
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of cofactors (Drosophila melanogaster)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Drosophila melanogaster)
BH2 binding can lead to eNOS uncoupling (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
Signal Transduction (Drosophila melanogaster)
Signaling by Nuclear Receptors (Drosophila melanogaster)
ESR-mediated signaling (Drosophila melanogaster)
Extra-nuclear estrogen signaling (Drosophila melanogaster)
eNOS synthesizes NO (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by VEGF (Drosophila melanogaster)
VEGFA-VEGFR2 Pathway (Drosophila melanogaster)
VEGFR2 mediated vascular permeability (Drosophila melanogaster)
AKT1 binds eNOS complex via HSP90 (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
AKT1 phosphorylates eNOS (Drosophila melanogaster)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
eNOS synthesizes NO (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
heme [cytosol]
Transport of small molecules (Drosophila melanogaster)
ABC-family proteins mediated transport (Drosophila melanogaster)
Mitochondrial ABC transporters (Drosophila melanogaster)
ABC7, mABC1 and mABC2 mediate heme transport (Drosophila melanogaster)
heme [cytosol]
Iron uptake and transport (Drosophila melanogaster)
FLVCR1-1 transports heme from cytosol to extracellular region (Drosophila melanogaster)
heme [cytosol]
HMOX1,2 cleave heme (Drosophila melanogaster)
heme [cytosol]
Cellular responses to external stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Detoxification of Reactive Oxygen Species (Gallus gallus)
NOX2 generates superoxide from oxygen (Gallus gallus)
NOX2 complex [phagocytic vesicle membrane] (Gallus gallus)
Cytochrome b-245 [phagocytic vesicle membrane] (Gallus gallus)
heme [cytosol]
Metabolism (Gallus gallus)
Metabolism of amino acids and derivatives (Gallus gallus)
Sulfur amino acid metabolism (Gallus gallus)
Cysteine formation from homocysteine (Gallus gallus)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Gallus gallus)
PXLP-CBS tetramers [cytosol] (Gallus gallus)
PXLP-K119-CBS tetramer [cytosol] (Gallus gallus)
heme [cytosol]
PXLP-K119-CBSL tetramer [cytosol] (Gallus gallus)
heme [cytosol]
Tryptophan catabolism (Gallus gallus)
IDO2 dioxygenates L-Trp to NFK (Gallus gallus)
IDO2 [cytosol] (Gallus gallus)
heme [cytosol]
TDO tetramer dioxygenates L-Trp to NFK (Gallus gallus)
TDO2 tetramer [cytosol] (Gallus gallus)
heme [cytosol]
Metabolism of nitric oxide: eNOS activation and regulation (Gallus gallus)
eNOS activation (Gallus gallus)
CYGB binds O2 (Gallus gallus)
CYGB dimer [cytosol] (Gallus gallus)
CYGB:heme [cytosol] (Gallus gallus)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Gallus gallus)
CYGB dimer [cytosol] (Gallus gallus)
CYGB:heme [cytosol] (Gallus gallus)
heme [cytosol]
CYGB dioxygenates NO (Gallus gallus)
CYGB dimer [cytosol] (Gallus gallus)
CYGB:heme [cytosol] (Gallus gallus)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Gallus gallus)
CYGB dimer [cytosol] (Gallus gallus)
CYGB:heme [cytosol] (Gallus gallus)
heme [cytosol]
Metabolism of porphyrins (Gallus gallus)
Heme biosynthesis (Gallus gallus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Gallus gallus)
heme [cytosol]
FLVCR1-1 transports heme from cytosol to extracellular region (Gallus gallus)
heme [cytosol]
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Gallus gallus)
heme [cytosol]
Heme degradation (Gallus gallus)
HMOX1,2 cleave heme (Gallus gallus)
heme [cytosol]
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Gallus gallus)
NOX2 complex [plasma membrane] (Gallus gallus)
Cytochrome b-245 [plasma membrane] (Gallus gallus)
heme [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Gallus gallus)
NOX2 complex [plasma membrane] (Gallus gallus)
Cytochrome b-245 [plasma membrane] (Gallus gallus)
heme [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Gallus gallus)
NOX2 complex:RAC1:GTP [plasma membrane] (Gallus gallus)
NOX2 complex [plasma membrane] (Gallus gallus)
Cytochrome b-245 [plasma membrane] (Gallus gallus)
heme [cytosol]
Signaling by Rho GTPases (Gallus gallus)
RHO GTPase Effectors (Gallus gallus)
RHO GTPases Activate NADPH Oxidases (Gallus gallus)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Gallus gallus)
NOX2 complex [plasma membrane] (Gallus gallus)
Cytochrome b-245 [plasma membrane] (Gallus gallus)
heme [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Gallus gallus)
NOX2 complex [plasma membrane] (Gallus gallus)
Cytochrome b-245 [plasma membrane] (Gallus gallus)
heme [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Gallus gallus)
NOX2 complex:RAC1:GTP [plasma membrane] (Gallus gallus)
NOX2 complex [plasma membrane] (Gallus gallus)
Cytochrome b-245 [plasma membrane] (Gallus gallus)
heme [cytosol]
Transport of small molecules (Gallus gallus)
ABC-family proteins mediated transport (Gallus gallus)
Mitochondrial ABC transporters (Gallus gallus)
ABC7, mABC1 and mABC2 mediate heme transport (Gallus gallus)
heme [cytosol]
Intracellular oxygen transport (Gallus gallus)
CYGB binds O2 (Gallus gallus)
CYGB dimer [cytosol] (Gallus gallus)
CYGB:heme [cytosol] (Gallus gallus)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Gallus gallus)
CYGB dimer [cytosol] (Gallus gallus)
CYGB:heme [cytosol] (Gallus gallus)
heme [cytosol]
CYGB:O2 dissociates (Gallus gallus)
CYGB dimer [cytosol] (Gallus gallus)
CYGB:heme [cytosol] (Gallus gallus)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Gallus gallus)
CYGB dimer [cytosol] (Gallus gallus)
CYGB:heme [cytosol] (Gallus gallus)
heme [cytosol]
Myoglobin binds oxygen (Gallus gallus)
MB:ferroheme b [cytosol] (Gallus gallus)
heme [cytosol]
MB:ferroheme b:O2 [cytosol] (Gallus gallus)
MB:ferroheme b [cytosol] (Gallus gallus)
heme [cytosol]
Myoglobin:oxygen dissociates (Gallus gallus)
MB:ferroheme b [cytosol] (Gallus gallus)
heme [cytosol]
MB:ferroheme b:O2 [cytosol] (Gallus gallus)
MB:ferroheme b [cytosol] (Gallus gallus)
heme [cytosol]
Neuroglobin binds oxygen (Gallus gallus)
NGB:ferroheme b [cytosol] (Gallus gallus)
heme [cytosol]
NGB:ferroheme b:O2 [cytosol] (Gallus gallus)
NGB:ferroheme b [cytosol] (Gallus gallus)
heme [cytosol]
Neuroglobin:oxygen dissociates (Gallus gallus)
NGB:ferroheme b [cytosol] (Gallus gallus)
heme [cytosol]
NGB:ferroheme b:O2 [cytosol] (Gallus gallus)
NGB:ferroheme b [cytosol] (Gallus gallus)
heme [cytosol]
Iron uptake and transport (Gallus gallus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Gallus gallus)
heme [cytosol]
FLVCR1-1 transports heme from cytosol to extracellular region (Gallus gallus)
heme [cytosol]
HMOX1,2 cleave heme (Gallus gallus)
heme [cytosol]
O2/CO2 exchange in erythrocytes (Gallus gallus)
Erythrocytes take up carbon dioxide and release oxygen (Gallus gallus)
CYB5Rs reduce MetHb to HbA (Gallus gallus)
HbA [cytosol] (Gallus gallus)
Hemoglobin alpha:ferroheme b [cytosol] (Gallus gallus)
heme [cytosol]
Hemoglobin beta:ferroheme b [cytosol] (Gallus gallus)
heme [cytosol]
Hemoglobin A is protonated and carbamated causing release of oxygen (Gallus gallus)
OxyHbA [cytosol] (Gallus gallus)
Hemoglobin alpha:ferroheme b:oxygen [cytosol] (Gallus gallus)
heme [cytosol]
Hemoglobin beta:ferroheme b:oxygen [cytosol] (Gallus gallus)
heme [cytosol]
Protonated Carbamino DeoxyHbA [cytosol] (Gallus gallus)
Protonated Carbamino Hemoglobin alpha:ferroheme b [cytosol] (Gallus gallus)
heme [cytosol]
Protonated Carbamino Hemoglobin beta: ferroheme b [cytosol] (Gallus gallus)
heme [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Gallus gallus)
Hemoglobin A binds oxygen and releases protons and carbon dioxide (Gallus gallus)
OxyHbA [cytosol] (Gallus gallus)
Hemoglobin alpha:ferroheme b:oxygen [cytosol] (Gallus gallus)
heme [cytosol]
Hemoglobin beta:ferroheme b:oxygen [cytosol] (Gallus gallus)
heme [cytosol]
Protonated Carbamino DeoxyHbA [cytosol] (Gallus gallus)
Protonated Carbamino Hemoglobin alpha:ferroheme b [cytosol] (Gallus gallus)
heme [cytosol]
Protonated Carbamino Hemoglobin beta: ferroheme b [cytosol] (Gallus gallus)
heme [cytosol]
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
NOX2 generates superoxide from oxygen (Homo sapiens)
NOX2 complex [phagocytic vesicle membrane] (Homo sapiens)
Cytochrome b-245 [phagocytic vesicle membrane] (Homo sapiens)
heme [cytosol]
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Infection with Mycobacterium tuberculosis (Homo sapiens)
Latent infection - Other responses of Mtb to phagocytosis (Homo sapiens)
Mtb iron assimilation by chelation (Homo sapiens)
BfrA stores iron (Homo sapiens)
BfrA complex [cytosol] (Mycobacterium tuberculosis)
BfrA dimer [cytosol] (Mycobacterium tuberculosis)
heme [cytosol]
Tolerance by Mtb to nitric oxide produced by macrophages (Homo sapiens)
Nitric oxide is oxidized to nitrate (Homo sapiens)
GlbN:Heme dimer [cytosol] (Mycobacterium tuberculosis)
heme [cytosol]
Tolerance of reactive oxygen produced by macrophages (Homo sapiens)
KatG reduces H2O2 (Homo sapiens)
KatG dimer [cytosol] (Mycobacterium tuberculosis)
heme [cytosol]
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
ROS and RNS production in phagocytes (Homo sapiens)
Nitric oxide oxidizes to nitrosyl ion (Homo sapiens)
heme [cytosol]
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Selenoamino acid metabolism (Homo sapiens)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Homo sapiens)
SeHCys and Ser are dehydrated into SeCysta by CBS (Homo sapiens)
PXLP-K119-CBS tetramer [cytosol] (Homo sapiens)
heme [cytosol]
Sulfur amino acid metabolism (Homo sapiens)
Cysteine formation from homocysteine (Homo sapiens)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Homo sapiens)
PXLP-CBS tetramers [cytosol] (Homo sapiens)
PXLP-K119-CBS tetramer [cytosol] (Homo sapiens)
heme [cytosol]
PXLP-K119-CBSL tetramer [cytosol] (Homo sapiens)
heme [cytosol]
Tryptophan catabolism (Homo sapiens)
IDO1 dioxygenates L-Trp to NFK (Homo sapiens)
IDO1 [cytosol] (Homo sapiens)
heme [cytosol]
IDO2 dioxygenates L-Trp to NFK (Homo sapiens)
IDO2 [cytosol] (Homo sapiens)
heme [cytosol]
TDO tetramer dioxygenates L-Trp to NFK (Homo sapiens)
TDO2 tetramer [cytosol] (Homo sapiens)
heme [cytosol]
Metabolism of nitric oxide: eNOS activation and regulation (Homo sapiens)
NOSIP mediated eNOS trafficking (Homo sapiens)
eNOS binds NOSIP (Homo sapiens)
eNOS:NOSIP [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Homo sapiens)
eNOS:NOSIP [Golgi membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Homo sapiens)
heme [cytosol]
eNOS:NOSIP [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
NOSTRIN mediated eNOS trafficking (Homo sapiens)
NOSTRIN mediated translocation of eNOS from plasma membrane (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Homo sapiens)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Homo sapiens)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
eNOS:Caveolin-1 complex binds to Nostrin (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN complex [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN complex [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
eNOS activation (Homo sapiens)
AKT1 binds eNOS complex via HSP90 (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
AKT1 phosphorylates eNOS (Homo sapiens)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
BH2 binding can lead to eNOS uncoupling (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
CYGB binds O2 (Homo sapiens)
CYGB dimer [cytosol] (Homo sapiens)
CYGB:heme [cytosol] (Homo sapiens)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Homo sapiens)
CYGB dimer [cytosol] (Homo sapiens)
CYGB:heme [cytosol] (Homo sapiens)
heme [cytosol]
CYGB dioxygenates NO (Homo sapiens)
CYGB dimer [cytosol] (Homo sapiens)
CYGB:heme [cytosol] (Homo sapiens)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Homo sapiens)
CYGB dimer [cytosol] (Homo sapiens)
CYGB:heme [cytosol] (Homo sapiens)
heme [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Homo sapiens)
eNOS:Caveolin-1:CaM [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
Uncoupled eNOS favours the formation of superoxide (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Homo sapiens)
myristoylated eNOS dimer [Golgi membrane] (Homo sapiens)
heme [cytosol]
myristoylated eNOS dimer [cytosol] (Homo sapiens)
heme [cytosol]
depalmitoylation of eNOS (Homo sapiens)
myristoylated eNOS dimer [cytosol] (Homo sapiens)
heme [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
eNOS associates with Caveolin-1 (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
eNOS synthesizes NO (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
eNOS translocation from Golgi to Caveolae (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
Metabolism of porphyrins (Homo sapiens)
Heme biosynthesis (Homo sapiens)
ABCG2 tetramer transports heme from cytosol to extracellular region (Homo sapiens)
heme [cytosol]
FLVCR1-1 transports heme from cytosol to extracellular region (Homo sapiens)
heme [cytosol]
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Homo sapiens)
heme [cytosol]
Heme degradation (Homo sapiens)
HMOX1,2 cleave heme (Homo sapiens)
heme [cytosol]
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of cofactors (Homo sapiens)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Homo sapiens)
BH2 binding can lead to eNOS uncoupling (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
eNOS synthesizes NO (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
heme [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
heme [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Homo sapiens)
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
heme [cytosol]
VEGFR2 mediated vascular permeability (Homo sapiens)
AKT1 binds eNOS complex via HSP90 (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
AKT1 phosphorylates eNOS (Homo sapiens)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Homo sapiens)
eNOS:Caveolin-1:CaM [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
eNOS synthesizes NO (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
heme [cytosol]
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate NADPH Oxidases (Homo sapiens)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
heme [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
heme [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Homo sapiens)
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
Cytochrome b-245 [plasma membrane] (Homo sapiens)
heme [cytosol]
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
Mitochondrial ABC transporters (Homo sapiens)
ABC7, mABC1 and mABC2 mediate heme transport (Homo sapiens)
heme [cytosol]
Intracellular oxygen transport (Homo sapiens)
CYGB binds O2 (Homo sapiens)
CYGB dimer [cytosol] (Homo sapiens)
CYGB:heme [cytosol] (Homo sapiens)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Homo sapiens)
CYGB dimer [cytosol] (Homo sapiens)
CYGB:heme [cytosol] (Homo sapiens)
heme [cytosol]
CYGB:O2 dissociates (Homo sapiens)
CYGB dimer [cytosol] (Homo sapiens)
CYGB:heme [cytosol] (Homo sapiens)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Homo sapiens)
CYGB dimer [cytosol] (Homo sapiens)
CYGB:heme [cytosol] (Homo sapiens)
heme [cytosol]
Myoglobin binds oxygen (Homo sapiens)
MB:ferroheme b [cytosol] (Homo sapiens)
heme [cytosol]
MB:ferroheme b:O2 [cytosol] (Homo sapiens)
MB:ferroheme b [cytosol] (Homo sapiens)
heme [cytosol]
Myoglobin:oxygen dissociates (Homo sapiens)
MB:ferroheme b [cytosol] (Homo sapiens)
heme [cytosol]
MB:ferroheme b:O2 [cytosol] (Homo sapiens)
MB:ferroheme b [cytosol] (Homo sapiens)
heme [cytosol]
Neuroglobin binds oxygen (Homo sapiens)
NGB:ferroheme b [cytosol] (Homo sapiens)
heme [cytosol]
NGB:ferroheme b:O2 [cytosol] (Homo sapiens)
NGB:ferroheme b [cytosol] (Homo sapiens)
heme [cytosol]
Neuroglobin:oxygen dissociates (Homo sapiens)
NGB:ferroheme b [cytosol] (Homo sapiens)
heme [cytosol]
NGB:ferroheme b:O2 [cytosol] (Homo sapiens)
NGB:ferroheme b [cytosol] (Homo sapiens)
heme [cytosol]
Iron uptake and transport (Homo sapiens)
ABCG2 tetramer transports heme from cytosol to extracellular region (Homo sapiens)
heme [cytosol]
FLVCR1-1 transports heme from cytosol to extracellular region (Homo sapiens)
heme [cytosol]
HMOX1,2 cleave heme (Homo sapiens)
heme [cytosol]
O2/CO2 exchange in erythrocytes (Homo sapiens)
Erythrocytes take up carbon dioxide and release oxygen (Homo sapiens)
CYB5Rs reduce MetHb to HbA (Homo sapiens)
HbA [cytosol] (Homo sapiens)
Hemoglobin alpha:ferroheme b [cytosol] (Homo sapiens)
heme [cytosol]
Hemoglobin beta:ferroheme b [cytosol] (Homo sapiens)
heme [cytosol]
Hemoglobin A is protonated and carbamated causing release of oxygen (Homo sapiens)
OxyHbA [cytosol] (Homo sapiens)
Hemoglobin alpha:ferroheme b:oxygen [cytosol] (Homo sapiens)
heme [cytosol]
Hemoglobin beta:ferroheme b:oxygen [cytosol] (Homo sapiens)
heme [cytosol]
Protonated Carbamino DeoxyHbA [cytosol] (Homo sapiens)
Protonated Carbamino Hemoglobin alpha:ferroheme b [cytosol] (Homo sapiens)
heme [cytosol]
Protonated Carbamino Hemoglobin beta: ferroheme b [cytosol] (Homo sapiens)
heme [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Homo sapiens)
Hemoglobin A binds oxygen and releases protons and carbon dioxide (Homo sapiens)
OxyHbA [cytosol] (Homo sapiens)
Hemoglobin alpha:ferroheme b:oxygen [cytosol] (Homo sapiens)
heme [cytosol]
Hemoglobin beta:ferroheme b:oxygen [cytosol] (Homo sapiens)
heme [cytosol]
Protonated Carbamino DeoxyHbA [cytosol] (Homo sapiens)
Protonated Carbamino Hemoglobin alpha:ferroheme b [cytosol] (Homo sapiens)
heme [cytosol]
Protonated Carbamino Hemoglobin beta: ferroheme b [cytosol] (Homo sapiens)
heme [cytosol]
Cellular responses to external stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Detoxification of Reactive Oxygen Species (Mus musculus)
NOX2 generates superoxide from oxygen (Mus musculus)
NOX2 complex [phagocytic vesicle membrane] (Mus musculus)
Cytochrome b-245 [phagocytic vesicle membrane] (Mus musculus)
heme [cytosol]
Metabolism (Mus musculus)
Metabolism of amino acids and derivatives (Mus musculus)
Sulfur amino acid metabolism (Mus musculus)
Cysteine formation from homocysteine (Mus musculus)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Mus musculus)
PXLP-CBS tetramers [cytosol] (Mus musculus)
PXLP-K119-CBS tetramer [cytosol] (Mus musculus)
heme [cytosol]
PXLP-K119-CBSL tetramer [cytosol] (Mus musculus)
heme [cytosol]
Tryptophan catabolism (Mus musculus)
IDO1 dioxygenates L-Trp to NFK (Mus musculus)
IDO1 [cytosol] (Mus musculus)
heme [cytosol]
IDO2 dioxygenates L-Trp to NFK (Mus musculus)
IDO2 [cytosol] (Mus musculus)
heme [cytosol]
TDO tetramer dioxygenates L-Trp to NFK (Mus musculus)
TDO2 tetramer [cytosol] (Mus musculus)
heme [cytosol]
Metabolism of nitric oxide: eNOS activation and regulation (Mus musculus)
NOSIP mediated eNOS trafficking (Mus musculus)
eNOS binds NOSIP (Mus musculus)
eNOS:NOSIP [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Mus musculus)
eNOS:NOSIP [Golgi membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Mus musculus)
heme [cytosol]
eNOS:NOSIP [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
NOSTRIN mediated eNOS trafficking (Mus musculus)
NOSTRIN mediated translocation of eNOS from plasma membrane (Mus musculus)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Mus musculus)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Mus musculus)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
eNOS:Caveolin-1 complex binds to Nostrin (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN complex [plasma membrane] (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Mus musculus)
eNOS:Caveolin-1:NOSTRIN complex [plasma membrane] (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Mus musculus)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
eNOS activation (Mus musculus)
AKT1 binds eNOS complex via HSP90 (Mus musculus)
eNOS:CaM:HSP90 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
eNOS:CaM:HSP90 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
AKT1 phosphorylates eNOS (Mus musculus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
eNOS:CaM:HSP90 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
BH2 binding can lead to eNOS uncoupling (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
CYGB binds O2 (Mus musculus)
CYGB dimer [cytosol] (Mus musculus)
CYGB:heme [cytosol] (Mus musculus)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Mus musculus)
CYGB dimer [cytosol] (Mus musculus)
CYGB:heme [cytosol] (Mus musculus)
heme [cytosol]
CYGB dioxygenates NO (Mus musculus)
CYGB dimer [cytosol] (Mus musculus)
CYGB:heme [cytosol] (Mus musculus)
heme [cytosol]
CYGB dimer:O2 [cytosol] (Mus musculus)
CYGB dimer [cytosol] (Mus musculus)
CYGB:heme [cytosol] (Mus musculus)
heme [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Mus musculus)
eNOS:CaM:HSP90 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Mus musculus)
eNOS:Caveolin-1:CaM [plasma membrane] (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
Uncoupled eNOS favours the formation of superoxide (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Mus musculus)
myristoylated eNOS dimer [Golgi membrane] (Mus musculus)
heme [cytosol]
myristoylated eNOS dimer [cytosol] (Mus musculus)
heme [cytosol]
depalmitoylation of eNOS (Mus musculus)
myristoylated eNOS dimer [cytosol] (Mus musculus)
heme [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
eNOS associates with Caveolin-1 (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
eNOS synthesizes NO (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
eNOS translocation from Golgi to Caveolae (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
Metabolism of porphyrins (Mus musculus)
Heme biosynthesis (Mus musculus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Mus musculus)
heme [cytosol]
FLVCR1-1 transports heme from cytosol to extracellular region (Mus musculus)
heme [cytosol]
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Mus musculus)
heme [cytosol]
Heme degradation (Mus musculus)
HMOX1,2 cleave heme (Mus musculus)
heme [cytosol]
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of cofactors (Mus musculus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Mus musculus)
BH2 binding can lead to eNOS uncoupling (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
Signal Transduction (Mus musculus)
Signaling by Nuclear Receptors (Mus musculus)
ESR-mediated signaling (Mus musculus)
Extra-nuclear estrogen signaling (Mus musculus)
eNOS synthesizes NO (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Mus musculus)
NOX2 complex [plasma membrane] (Mus musculus)
Cytochrome b-245 [plasma membrane] (Mus musculus)
heme [cytosol]
NOX2 complex:RAC1:GTP [plasma membrane] (Mus musculus)
NOX2 complex [plasma membrane] (Mus musculus)
Cytochrome b-245 [plasma membrane] (Mus musculus)
heme [cytosol]
NADPH oxidase 2 generates superoxide from oxygen (Mus musculus)
NOX2 complex:RAC1:GTP [plasma membrane] (Mus musculus)
NOX2 complex [plasma membrane] (Mus musculus)
Cytochrome b-245 [plasma membrane] (Mus musculus)
heme [cytosol]
VEGFR2 mediated vascular permeability (Mus musculus)
AKT1 binds eNOS complex via HSP90 (Mus musculus)
eNOS:CaM:HSP90 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
heme [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
eNOS:CaM:HSP90 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS