Reactome | AdoMet [cytosol]

Cellular responses to external stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Amino acids regulate mTORC1 (Homo sapiens)
    - BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Homo sapiens)
      - AdoMet [cytosol]
      - BMT2:AdoMet [cytosol] (Homo sapiens)
        
        AdoMet [cytosol]

Chromatin organization (Homo sapiens)

- Chromatin modifying enzymes (Homo sapiens)
  - PKMTs methylate histone lysines (Homo sapiens)
    - MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Homo sapiens)
      - AdoMet [cytosol]
  - RMTs methylate histone arginines (Homo sapiens)
    - PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Homo sapiens)
      - AdoMet [cytosol]

Disease (Homo sapiens)

- Diseases of metabolism (Homo sapiens)
  - Defects in vitamin and cofactor metabolism (Homo sapiens)
    - Defects in cobalamin (B12) metabolism (Homo sapiens)
      - Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (Homo sapiens)
        
        Defective MTRR does not convert cob(II)alamin to MeCbl (Homo sapiens)
        
        AdoMet [cytosol]
  - Metabolic disorders of biological oxidation enzymes (Homo sapiens)
    - Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) (Homo sapiens)
      - TPMT does not transfer CH3 from AdoMet to 6MP (Homo sapiens)
        
        AdoMet [cytosol]

Gene expression (Transcription) (Homo sapiens)

- Gene Silencing by RNA (Homo sapiens)
  - MicroRNA (miRNA) biogenesis (Homo sapiens)
    - BCDIN3D dimethylates 5' phosphate of pre-miR-145 (Homo sapiens)
      - AdoMet [cytosol]
  - PIWI-interacting RNA (piRNA) biogenesis (Homo sapiens)

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - FLT3 Signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - RAS processing (Homo sapiens)
        
        ICMT methylates S-Farn RAS proteins (Homo sapiens)
        
        AdoMet [cytosol]

Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase II - Conjugation of compounds (Homo sapiens)
    - Methylation (Homo sapiens)
- Metabolism of amino acids and derivatives (Homo sapiens)
  - Creatine metabolism (Homo sapiens)
    - guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Homo sapiens)
      - AdoMet [cytosol]
  - Glyoxylate metabolism and glycine degradation (Homo sapiens)
    - GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Homo sapiens)
      - AdoMet [cytosol]
  - Histidine catabolism (Homo sapiens)
    - CARNMT1 methylates CARN to Anserine (Homo sapiens)
      - AdoMet [cytosol]
    - HNMT transfers CH3 group from AdoMet to Hist (Homo sapiens)
      - AdoMet [cytosol]
  - Metabolism of amine-derived hormones (Homo sapiens)
    - Catecholamine biosynthesis (Homo sapiens)
      - Noradrenaline is converted to adrenaline (Homo sapiens)
        
        AdoMet [cytosol]
    - Serotonin and melatonin biosynthesis (Homo sapiens)
      - Methylation of N-acetyl-5-HT to form melatonin (Homo sapiens)
        
        AdoMet [cytosol]
  - Metabolism of polyamines (Homo sapiens)
    - S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Homo sapiens)
      - AdoMet [cytosol]
  - Selenoamino acid metabolism (Homo sapiens)
    - Formation of selenosugars for excretion (Homo sapiens)
      - GSSebGalNac is reduced and methylated to MeSebGalNac (Homo sapiens)
        
        AdoMet [cytosol]
    - Metabolism of ingested SeMet, Sec, MeSec into H2Se (Homo sapiens)
      - H2Se is methylated to MeSeH by H2Se methyltransferase (Homo sapiens)
        
        AdoMet [cytosol]
    - Methylation of MeSeH for excretion (Homo sapiens)
      - Me2Se is methylated to Me3Se+ by INMT (Homo sapiens)
        
        AdoMet [cytosol]
      - MeSeH is methylated to Me2Se by MeSeH methyltransferase (Homo sapiens)
        
        AdoMet [cytosol]
  - Sulfur amino acid metabolism (Homo sapiens)
    - MAT1A multimers transfer Ado from ATP to L-Met (Homo sapiens)
      - AdoMet [cytosol]
- Metabolism of lipids (Homo sapiens)
  - Phospholipid metabolism (Homo sapiens)
    - Glycerophospholipid biosynthesis (Homo sapiens)
      - Synthesis of PC (Homo sapiens)
        
        PE is methylated to PC by PEMT (Homo sapiens)
        
        AdoMet [cytosol]
- Metabolism of vitamins and cofactors (Homo sapiens)
  - Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
    - Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)
      - MTRR reduces cob(II)alamin to meCbl (Homo sapiens)
        
        AdoMet [cytosol]
    - Molybdenum cofactor biosynthesis (Homo sapiens)
      - Cyclisation of GTP to precursor Z (Homo sapiens)
        
        AdoMet [cytosol]
    - Nicotinate metabolism (Homo sapiens)
      - Nicotinamide salvaging (Homo sapiens)
        
        NNMT transfers CH3 from SAM to NAM to form MNA (Homo sapiens)
        
        AdoMet [cytosol]

Metabolism of RNA (Homo sapiens)

- Metabolism of non-coding RNA (Homo sapiens)
  - snRNP Assembly (Homo sapiens)
    - Loading and methylation of Sm proteins onto SMN Complexes (Homo sapiens)
      - AdoMet [cytosol]
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - rRNA modification in the nucleus and cytosol (Homo sapiens)
      - TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248 (Homo sapiens)
        
        AdoMet [cytosol]
- tRNA processing (Homo sapiens)
  - tRNA modification in the nucleus and cytosol (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Gamma carboxylation, hypusine formation and arylsulfatase activation (Homo sapiens)
    - ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Homo sapiens)
      - AdoMet [cytosol]
    - Synthesis of diphthamide-EEF2 (Homo sapiens)
      - DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Homo sapiens)
        
        AdoMet [cytosol]
      - DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Homo sapiens)
        
        AdoMet [cytosol]
  - Protein methylation (Homo sapiens)
- Protein repair (Homo sapiens)
  - PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Homo sapiens)
    - AdoMet [cytosol]
- Translation (Homo sapiens)
  - Eukaryotic Translation Termination (Homo sapiens)
    - N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Homo sapiens)
      - AdoMet [cytosol]

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter clearance (Homo sapiens)
    - Dopamine clearance from the synaptic cleft (Homo sapiens)
      - Enzymatic degradation of Dopamine by monoamine oxidase (Homo sapiens)
        
        COMT transfers Met to DOPAC to form HVA (Homo sapiens)
        
        AdoMet [cytosol]
      - Enzymatic degradation of dopamine by COMT (Homo sapiens)
        
        COMT transfers Met to DA to form 3MT (Homo sapiens)
        
        AdoMet [cytosol]
        
        LRTOMT transfers Met to DA, forming 3MT (Homo sapiens)
        
        AdoMet [cytosol]

Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - RAS processing (Homo sapiens)
        
        ICMT methylates S-Farn RAS proteins (Homo sapiens)
        
        AdoMet [cytosol]
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Visual phototransduction (Homo sapiens)
        
        The phototransduction cascade (Homo sapiens)
        
        Inactivation, recovery and regulation of the phototransduction cascade (Homo sapiens)
        
        KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Homo sapiens)
        
        AdoMet [cytosol]

Transport of small molecules (Homo sapiens)

- SLC-mediated transmembrane transport (Homo sapiens)
  - Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
    - SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Homo sapiens)
      - AdoMet [cytosol]