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About
What is Reactome ?
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Our Logo
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Digital Preservation
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FMN [cytosol]
Stable Identifier
R-ALL-73524
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
Flavin mononucleotide, Riboflavin-5-phosphate
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Mycobacterium tuberculosis
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to mechanical stimuli (Bos taurus)
Response of endothelial cells to shear stress (Bos taurus)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Bos taurus)
PKA phosphorylates NOS3 (eNOS) on serine-633 (Bos taurus)
p-S633-eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Bos taurus)
p-S1177,S1179-eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
Metabolism (Bos taurus)
Biological oxidations (Bos taurus)
Phase II - Conjugation of compounds (Bos taurus)
Methylation (Bos taurus)
MTR transfers CH3 from MeCbl to HCYS (Bos taurus)
MTRR:MTR:MeCbl [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FMN [cytosol]
Metabolism of amino acids and derivatives (Bos taurus)
Metabolism of amine-derived hormones (Bos taurus)
Thyroxine biosynthesis (Bos taurus)
Diiodinated tyrosine can be deiodinated (Bos taurus)
DEHAL1:FMN [plasma membrane] (Bos taurus)
FMN [cytosol]
Monoiodinated tyrosine can be deiodinated (Bos taurus)
DEHAL1:FMN [plasma membrane] (Bos taurus)
FMN [cytosol]
Sulfur amino acid metabolism (Bos taurus)
MTR transfers CH3 from MeCbl to HCYS (Bos taurus)
MTRR:MTR:MeCbl [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FMN [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Bos taurus)
NOSIP mediated eNOS trafficking (Bos taurus)
eNOS binds NOSIP (Bos taurus)
eNOS:NOSIP [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Bos taurus)
eNOS:NOSIP [Golgi membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Bos taurus)
FMN [cytosol]
eNOS:NOSIP [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
NOSTRIN mediated eNOS trafficking (Bos taurus)
NOSTRIN mediated translocation of eNOS from plasma membrane (Bos taurus)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Bos taurus)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Bos taurus)
FMN [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Bos taurus)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
eNOS activation (Bos taurus)
AKT1 phosphorylates eNOS (Bos taurus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
eNOS:CaM:HSP90 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
BH2 binding can lead to eNOS uncoupling (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Bos taurus)
eNOS:CaM:HSP90 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
Depalmitoylation of eNOS (Bos taurus)
myristoylated eNOS dimer [cytosol] (Bos taurus)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Bos taurus)
eNOS:Caveolin-1:CaM [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
Uncoupled eNOS favours the formation of superoxide (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Bos taurus)
myristoylated eNOS dimer [Golgi membrane] (Bos taurus)
FMN [cytosol]
myristoylated eNOS dimer [cytosol] (Bos taurus)
FMN [cytosol]
eNOS associates with Caveolin-1 (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
eNOS synthesizes NO (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
eNOS translocation from Golgi to Caveolae (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
Metabolism of nucleotides (Bos taurus)
Nucleotide catabolism (Bos taurus)
Pyrimidine catabolism (Bos taurus)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Bos taurus)
DPYD dimer [cytosol] (Bos taurus)
FMN [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Bos taurus)
DPYD dimer [cytosol] (Bos taurus)
FMN [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of cofactors (Bos taurus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Bos taurus)
BH2 binding can lead to eNOS uncoupling (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Bos taurus)
Cobalamin (Cbl) metabolism (Bos taurus)
MTR transfers CH3 from MeCbl to HCYS (Bos taurus)
MTRR:MTR:MeCbl [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FMN [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Bos taurus)
MTRR:MTR:MeCbl [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FMN [cytosol]
MTRR reduces cob(II)alamin to meCbl (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FMN [cytosol]
MTRR:MTR:MeCbl [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FMN [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Bos taurus)
MTRR:MTR [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FMN [cytosol]
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Bos taurus)
MTRR:MTR [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FMN [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Bos taurus)
MTRR:MTR [cytosol] (Bos taurus)
MTRR:FMN:FAD [cytosol] (Bos taurus)
FMN [cytosol]
Vitamin B2 (riboflavin) metabolism (Bos taurus)
2xENPP1 hydrolyzes FAD to FMN (Bos taurus)
FMN [cytosol]
2xTRAP hydrolyzes FMN to RIB (Bos taurus)
FMN [cytosol]
FLAD1 phosphorylates FMN (Bos taurus)
FMN [cytosol]
RFK:Mg2+ phosphorylates RIB (Bos taurus)
FMN [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Bos taurus)
FMN [cytosol]
Vitamin B5 (pantothenate) metabolism (Bos taurus)
Coenzyme A biosynthesis (Bos taurus)
3xPPCDC:3FMN decarboxylates PPC (Bos taurus)
3xPPCDC:3xFMN [cytosol] (Bos taurus)
FMN [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Bos taurus)
2xPNPO:2xFMN oxidizes PDXP to PXLP (Bos taurus)
2xPNPO:2xFMN [cytosol] (Bos taurus)
FMN [cytosol]
2xPNPO:2xFMN oxidizes PXAP to PXLP (Bos taurus)
2xPNPO:2xFMN [cytosol] (Bos taurus)
FMN [cytosol]
Signal Transduction (Bos taurus)
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Extra-nuclear estrogen signaling (Bos taurus)
eNOS synthesizes NO (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
VEGFR2 mediated vascular permeability (Bos taurus)
AKT1 phosphorylates eNOS (Bos taurus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
eNOS:CaM:HSP90 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Bos taurus)
eNOS:CaM:HSP90 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Bos taurus)
eNOS:Caveolin-1:CaM [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
eNOS synthesizes NO (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Bos taurus)
eNOS:Caveolin-1 [plasma membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Bos taurus)
FMN [cytosol]
Metabolism (Caenorhabditis elegans)
Biological oxidations (Caenorhabditis elegans)
Phase II - Conjugation of compounds (Caenorhabditis elegans)
Methylation (Caenorhabditis elegans)
MTR transfers CH3 from MeCbl to HCYS (Caenorhabditis elegans)
MTRR:MTR:MeCbl [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FMN [cytosol]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Metabolism of amine-derived hormones (Caenorhabditis elegans)
Thyroxine biosynthesis (Caenorhabditis elegans)
Diiodinated tyrosine can be deiodinated (Caenorhabditis elegans)
DEHAL1:FMN [plasma membrane] (Caenorhabditis elegans)
FMN [cytosol]
Monoiodinated tyrosine can be deiodinated (Caenorhabditis elegans)
DEHAL1:FMN [plasma membrane] (Caenorhabditis elegans)
FMN [cytosol]
Sulfur amino acid metabolism (Caenorhabditis elegans)
MTR transfers CH3 from MeCbl to HCYS (Caenorhabditis elegans)
MTRR:MTR:MeCbl [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FMN [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Caenorhabditis elegans)
eNOS activation (Caenorhabditis elegans)
AKT1 phosphorylates eNOS (Caenorhabditis elegans)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
eNOS:CaM:HSP90 [plasma membrane] (Caenorhabditis elegans)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FMN [cytosol]
BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FMN [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FMN [cytosol]
Uncoupled eNOS favours the formation of superoxide (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FMN [cytosol]
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FMN [cytosol]
Metabolism of nucleotides (Caenorhabditis elegans)
Nucleotide catabolism (Caenorhabditis elegans)
Pyrimidine catabolism (Caenorhabditis elegans)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Caenorhabditis elegans)
DPYD dimer [cytosol] (Caenorhabditis elegans)
FMN [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Caenorhabditis elegans)
DPYD dimer [cytosol] (Caenorhabditis elegans)
FMN [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of cofactors (Caenorhabditis elegans)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Caenorhabditis elegans)
BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FMN [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FMN [cytosol]
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Caenorhabditis elegans)
Cobalamin (Cbl) metabolism (Caenorhabditis elegans)
MTR transfers CH3 from MeCbl to HCYS (Caenorhabditis elegans)
MTRR:MTR:MeCbl [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FMN [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Caenorhabditis elegans)
MTRR:MTR:MeCbl [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FMN [cytosol]
MTRR reduces cob(II)alamin to meCbl (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FMN [cytosol]
MTRR:MTR:MeCbl [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FMN [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Caenorhabditis elegans)
MTRR:MTR [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FMN [cytosol]
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Caenorhabditis elegans)
MTRR:MTR [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FMN [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Caenorhabditis elegans)
MTRR:MTR [cytosol] (Caenorhabditis elegans)
MTRR:FMN:FAD [cytosol] (Caenorhabditis elegans)
FMN [cytosol]
Vitamin B2 (riboflavin) metabolism (Caenorhabditis elegans)
2xENPP1 hydrolyzes FAD to FMN (Caenorhabditis elegans)
FMN [cytosol]
2xTRAP hydrolyzes FMN to RIB (Caenorhabditis elegans)
FMN [cytosol]
FLAD1 phosphorylates FMN (Caenorhabditis elegans)
FMN [cytosol]
RFK:Mg2+ phosphorylates RIB (Caenorhabditis elegans)
FMN [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Caenorhabditis elegans)
FMN [cytosol]
Vitamin B5 (pantothenate) metabolism (Caenorhabditis elegans)
Coenzyme A biosynthesis (Caenorhabditis elegans)
3xPPCDC:3FMN decarboxylates PPC (Caenorhabditis elegans)
3xPPCDC:3xFMN [cytosol] (Caenorhabditis elegans)
FMN [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Caenorhabditis elegans)
2xPNPO:2xFMN oxidizes PDXP to PXLP (Caenorhabditis elegans)
2xPNPO:2xFMN [cytosol] (Caenorhabditis elegans)
FMN [cytosol]
2xPNPO:2xFMN oxidizes PXAP to PXLP (Caenorhabditis elegans)
2xPNPO:2xFMN [cytosol] (Caenorhabditis elegans)
FMN [cytosol]
Signal Transduction (Caenorhabditis elegans)
Signaling by Nuclear Receptors (Caenorhabditis elegans)
ESR-mediated signaling (Caenorhabditis elegans)
Extra-nuclear estrogen signaling (Caenorhabditis elegans)
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FMN [cytosol]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
VEGFR2 mediated vascular permeability (Caenorhabditis elegans)
AKT1 phosphorylates eNOS (Caenorhabditis elegans)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
eNOS:CaM:HSP90 [plasma membrane] (Caenorhabditis elegans)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FMN [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FMN [cytosol]
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
FMN [cytosol]
Metabolism (Canis familiaris)
Biological oxidations (Canis familiaris)
Phase II - Conjugation of compounds (Canis familiaris)
Methylation (Canis familiaris)
MTR transfers CH3 from MeCbl to HCYS (Canis familiaris)
MTRR:MTR:MeCbl [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FMN [cytosol]
Metabolism of amino acids and derivatives (Canis familiaris)
Metabolism of amine-derived hormones (Canis familiaris)
Thyroxine biosynthesis (Canis familiaris)
Diiodinated tyrosine can be deiodinated (Canis familiaris)
DEHAL1:FMN [plasma membrane] (Canis familiaris)
FMN [cytosol]
Monoiodinated tyrosine can be deiodinated (Canis familiaris)
DEHAL1:FMN [plasma membrane] (Canis familiaris)
FMN [cytosol]
Sulfur amino acid metabolism (Canis familiaris)
MTR transfers CH3 from MeCbl to HCYS (Canis familiaris)
MTRR:MTR:MeCbl [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FMN [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Canis familiaris)
NOSTRIN mediated eNOS trafficking (Canis familiaris)
NOSTRIN mediated translocation of eNOS from plasma membrane (Canis familiaris)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Canis familiaris)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Canis familiaris)
FMN [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FMN [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Canis familiaris)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FMN [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Canis familiaris)
FMN [cytosol]
Metabolism of nucleotides (Canis familiaris)
Nucleotide catabolism (Canis familiaris)
Pyrimidine catabolism (Canis familiaris)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Canis familiaris)
DPYD dimer [cytosol] (Canis familiaris)
FMN [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Canis familiaris)
DPYD dimer [cytosol] (Canis familiaris)
FMN [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Canis familiaris)
Cobalamin (Cbl) metabolism (Canis familiaris)
MTR transfers CH3 from MeCbl to HCYS (Canis familiaris)
MTRR:MTR:MeCbl [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FMN [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Canis familiaris)
MTRR:MTR:MeCbl [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FMN [cytosol]
MTRR reduces cob(II)alamin to meCbl (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FMN [cytosol]
MTRR:MTR:MeCbl [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FMN [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Canis familiaris)
MTRR:MTR [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FMN [cytosol]
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Canis familiaris)
MTRR:MTR [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FMN [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Canis familiaris)
MTRR:MTR [cytosol] (Canis familiaris)
MTRR:FMN:FAD [cytosol] (Canis familiaris)
FMN [cytosol]
Vitamin B2 (riboflavin) metabolism (Canis familiaris)
2xENPP1 hydrolyzes FAD to FMN (Canis familiaris)
FMN [cytosol]
2xTRAP hydrolyzes FMN to RIB (Canis familiaris)
FMN [cytosol]
FLAD1 phosphorylates FMN (Canis familiaris)
FMN [cytosol]
RFK:Mg2+ phosphorylates RIB (Canis familiaris)
FMN [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Canis familiaris)
FMN [cytosol]
Vitamin B5 (pantothenate) metabolism (Canis familiaris)
Coenzyme A biosynthesis (Canis familiaris)
3xPPCDC:3FMN decarboxylates PPC (Canis familiaris)
3xPPCDC:3xFMN [cytosol] (Canis familiaris)
FMN [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Canis familiaris)
2xPNPO:2xFMN oxidizes PDXP to PXLP (Canis familiaris)
2xPNPO:2xFMN [cytosol] (Canis familiaris)
FMN [cytosol]
2xPNPO:2xFMN oxidizes PXAP to PXLP (Canis familiaris)
2xPNPO:2xFMN [cytosol] (Canis familiaris)
FMN [cytosol]
Metabolism (Danio rerio)
Metabolism of amino acids and derivatives (Danio rerio)
Metabolism of amine-derived hormones (Danio rerio)
Thyroxine biosynthesis (Danio rerio)
Diiodinated tyrosine can be deiodinated (Danio rerio)
DEHAL1:FMN [plasma membrane] (Danio rerio)
FMN [cytosol]
Monoiodinated tyrosine can be deiodinated (Danio rerio)
DEHAL1:FMN [plasma membrane] (Danio rerio)
FMN [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Danio rerio)
NOSTRIN mediated eNOS trafficking (Danio rerio)
NOSTRIN mediated translocation of eNOS from plasma membrane (Danio rerio)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Danio rerio)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Danio rerio)
FMN [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Danio rerio)
FMN [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Danio rerio)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Danio rerio)
FMN [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Danio rerio)
FMN [cytosol]
Metabolism of nucleotides (Danio rerio)
Nucleotide catabolism (Danio rerio)
Pyrimidine catabolism (Danio rerio)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Danio rerio)
DPYD dimer [cytosol] (Danio rerio)
FMN [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Danio rerio)
DPYD dimer [cytosol] (Danio rerio)
FMN [cytosol]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Vitamin B2 (riboflavin) metabolism (Danio rerio)
2xENPP1 hydrolyzes FAD to FMN (Danio rerio)
FMN [cytosol]
2xTRAP hydrolyzes FMN to RIB (Danio rerio)
FMN [cytosol]
FLAD1 phosphorylates FMN (Danio rerio)
FMN [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Danio rerio)
FMN [cytosol]
Cellular responses to stimuli (Dictyostelium discoideum)
Cellular responses to mechanical stimuli (Dictyostelium discoideum)
Response of endothelial cells to shear stress (Dictyostelium discoideum)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Dictyostelium discoideum)
Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Dictyostelium discoideum)
p-S1177,S1179-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
Metabolism (Dictyostelium discoideum)
Biological oxidations (Dictyostelium discoideum)
Phase II - Conjugation of compounds (Dictyostelium discoideum)
Methylation (Dictyostelium discoideum)
MTR transfers CH3 from MeCbl to HCYS (Dictyostelium discoideum)
MTRR:MTR:MeCbl [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FMN [cytosol]
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Sulfur amino acid metabolism (Dictyostelium discoideum)
MTR transfers CH3 from MeCbl to HCYS (Dictyostelium discoideum)
MTRR:MTR:MeCbl [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FMN [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Dictyostelium discoideum)
NOSIP mediated eNOS trafficking (Dictyostelium discoideum)
eNOS binds NOSIP (Dictyostelium discoideum)
eNOS:NOSIP [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Dictyostelium discoideum)
eNOS:NOSIP [Golgi membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Dictyostelium discoideum)
FMN [cytosol]
eNOS:NOSIP [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
eNOS activation (Dictyostelium discoideum)
AKT1 binds eNOS complex via HSP90 (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
AKT1 phosphorylates eNOS (Dictyostelium discoideum)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
Depalmitoylation of eNOS (Dictyostelium discoideum)
myristoylated eNOS dimer [cytosol] (Dictyostelium discoideum)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
Uncoupled eNOS favours the formation of superoxide (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Dictyostelium discoideum)
myristoylated eNOS dimer [Golgi membrane] (Dictyostelium discoideum)
FMN [cytosol]
myristoylated eNOS dimer [cytosol] (Dictyostelium discoideum)
FMN [cytosol]
eNOS synthesizes NO (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
eNOS translocation from Golgi to Caveolae (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
Metabolism of nucleotides (Dictyostelium discoideum)
Nucleotide catabolism (Dictyostelium discoideum)
Pyrimidine catabolism (Dictyostelium discoideum)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Dictyostelium discoideum)
DPYD dimer [cytosol] (Dictyostelium discoideum)
FMN [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Dictyostelium discoideum)
DPYD dimer [cytosol] (Dictyostelium discoideum)
FMN [cytosol]
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of cofactors (Dictyostelium discoideum)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Dictyostelium discoideum)
BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
Metabolism of water-soluble vitamins and cofactors (Dictyostelium discoideum)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Dictyostelium discoideum)
Cobalamin (Cbl) metabolism (Dictyostelium discoideum)
MTR transfers CH3 from MeCbl to HCYS (Dictyostelium discoideum)
MTRR:MTR:MeCbl [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FMN [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Dictyostelium discoideum)
MTRR:MTR:MeCbl [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FMN [cytosol]
MTRR reduces cob(II)alamin to meCbl (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FMN [cytosol]
MTRR:MTR:MeCbl [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FMN [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Dictyostelium discoideum)
MTRR:MTR [cytosol] (Dictyostelium discoideum)
MTRR:FMN:FAD [cytosol] (Dictyostelium discoideum)
FMN [cytosol]
Vitamin B2 (riboflavin) metabolism (Dictyostelium discoideum)
2xENPP1 hydrolyzes FAD to FMN (Dictyostelium discoideum)
FMN [cytosol]
FLAD1 phosphorylates FMN (Dictyostelium discoideum)
FMN [cytosol]
Vitamin B5 (pantothenate) metabolism (Dictyostelium discoideum)
Coenzyme A biosynthesis (Dictyostelium discoideum)
3xPPCDC:3FMN decarboxylates PPC (Dictyostelium discoideum)
3xPPCDC:3xFMN [cytosol] (Dictyostelium discoideum)
FMN [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Dictyostelium discoideum)
2xPNPO:2xFMN oxidizes PDXP to PXLP (Dictyostelium discoideum)
2xPNPO:2xFMN [cytosol] (Dictyostelium discoideum)
FMN [cytosol]
2xPNPO:2xFMN oxidizes PXAP to PXLP (Dictyostelium discoideum)
2xPNPO:2xFMN [cytosol] (Dictyostelium discoideum)
FMN [cytosol]
Signal Transduction (Dictyostelium discoideum)
Signaling by Nuclear Receptors (Dictyostelium discoideum)
ESR-mediated signaling (Dictyostelium discoideum)
Extra-nuclear estrogen signaling (Dictyostelium discoideum)
eNOS synthesizes NO (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
Signaling by Receptor Tyrosine Kinases (Dictyostelium discoideum)
Signaling by VEGF (Dictyostelium discoideum)
VEGFA-VEGFR2 Pathway (Dictyostelium discoideum)
VEGFR2 mediated vascular permeability (Dictyostelium discoideum)
AKT1 binds eNOS complex via HSP90 (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
AKT1 phosphorylates eNOS (Dictyostelium discoideum)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
eNOS:CaM:HSP90 [plasma membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
eNOS synthesizes NO (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
FMN [cytosol]
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to mechanical stimuli (Drosophila melanogaster)
Response of endothelial cells to shear stress (Drosophila melanogaster)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Drosophila melanogaster)
PKA phosphorylates NOS3 (eNOS) on serine-633 (Drosophila melanogaster)
p-S633-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Drosophila melanogaster)
p-S1177,S1179-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Metabolism of amine-derived hormones (Drosophila melanogaster)
Thyroxine biosynthesis (Drosophila melanogaster)
Diiodinated tyrosine can be deiodinated (Drosophila melanogaster)
DEHAL1:FMN [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
Monoiodinated tyrosine can be deiodinated (Drosophila melanogaster)
DEHAL1:FMN [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Drosophila melanogaster)
NOSIP mediated eNOS trafficking (Drosophila melanogaster)
eNOS binds NOSIP (Drosophila melanogaster)
eNOS:NOSIP [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Drosophila melanogaster)
eNOS:NOSIP [Golgi membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Drosophila melanogaster)
FMN [cytosol]
eNOS:NOSIP [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
eNOS activation (Drosophila melanogaster)
AKT1 binds eNOS complex via HSP90 (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
AKT1 phosphorylates eNOS (Drosophila melanogaster)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
BH2 binding can lead to eNOS uncoupling (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
Depalmitoylation of eNOS (Drosophila melanogaster)
myristoylated eNOS dimer [cytosol] (Drosophila melanogaster)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
Uncoupled eNOS favours the formation of superoxide (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Drosophila melanogaster)
myristoylated eNOS dimer [Golgi membrane] (Drosophila melanogaster)
FMN [cytosol]
myristoylated eNOS dimer [cytosol] (Drosophila melanogaster)
FMN [cytosol]
eNOS synthesizes NO (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
eNOS translocation from Golgi to Caveolae (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
Metabolism of nucleotides (Drosophila melanogaster)
Nucleotide catabolism (Drosophila melanogaster)
Pyrimidine catabolism (Drosophila melanogaster)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Drosophila melanogaster)
DPYD dimer [cytosol] (Drosophila melanogaster)
FMN [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Drosophila melanogaster)
DPYD dimer [cytosol] (Drosophila melanogaster)
FMN [cytosol]
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of cofactors (Drosophila melanogaster)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Drosophila melanogaster)
BH2 binding can lead to eNOS uncoupling (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
Metabolism of water-soluble vitamins and cofactors (Drosophila melanogaster)
Vitamin B2 (riboflavin) metabolism (Drosophila melanogaster)
FLAD1 phosphorylates FMN (Drosophila melanogaster)
FMN [cytosol]
RFK:Mg2+ phosphorylates RIB (Drosophila melanogaster)
FMN [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Drosophila melanogaster)
FMN [cytosol]
Vitamin B5 (pantothenate) metabolism (Drosophila melanogaster)
Coenzyme A biosynthesis (Drosophila melanogaster)
3xPPCDC:3FMN decarboxylates PPC (Drosophila melanogaster)
3xPPCDC:3xFMN [cytosol] (Drosophila melanogaster)
FMN [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Drosophila melanogaster)
2xPNPO:2xFMN oxidizes PDXP to PXLP (Drosophila melanogaster)
2xPNPO:2xFMN [cytosol] (Drosophila melanogaster)
FMN [cytosol]
2xPNPO:2xFMN oxidizes PXAP to PXLP (Drosophila melanogaster)
2xPNPO:2xFMN [cytosol] (Drosophila melanogaster)
FMN [cytosol]
Signal Transduction (Drosophila melanogaster)
Signaling by Nuclear Receptors (Drosophila melanogaster)
ESR-mediated signaling (Drosophila melanogaster)
Extra-nuclear estrogen signaling (Drosophila melanogaster)
eNOS synthesizes NO (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by VEGF (Drosophila melanogaster)
VEGFA-VEGFR2 Pathway (Drosophila melanogaster)
VEGFR2 mediated vascular permeability (Drosophila melanogaster)
AKT1 binds eNOS complex via HSP90 (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
AKT1 phosphorylates eNOS (Drosophila melanogaster)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
eNOS:CaM:HSP90 [plasma membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
eNOS synthesizes NO (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
FMN [cytosol]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to mechanical stimuli (Gallus gallus)
Response of endothelial cells to shear stress (Gallus gallus)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Gallus gallus)
PKA phosphorylates NOS3 (eNOS) on serine-633 (Gallus gallus)
p-S633-eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Gallus gallus)
p-S1177,S1179-eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
Metabolism (Gallus gallus)
Biological oxidations (Gallus gallus)
Phase II - Conjugation of compounds (Gallus gallus)
Methylation (Gallus gallus)
MTR transfers CH3 from MeCbl to HCYS (Gallus gallus)
MTRR:MTR:MeCbl [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FMN [cytosol]
Metabolism of amino acids and derivatives (Gallus gallus)
Metabolism of amine-derived hormones (Gallus gallus)
Thyroxine biosynthesis (Gallus gallus)
Diiodinated tyrosine can be deiodinated (Gallus gallus)
DEHAL1:FMN [plasma membrane] (Gallus gallus)
FMN [cytosol]
Monoiodinated tyrosine can be deiodinated (Gallus gallus)
DEHAL1:FMN [plasma membrane] (Gallus gallus)
FMN [cytosol]
Sulfur amino acid metabolism (Gallus gallus)
MTR transfers CH3 from MeCbl to HCYS (Gallus gallus)
MTRR:MTR:MeCbl [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FMN [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Gallus gallus)
NOSTRIN mediated eNOS trafficking (Gallus gallus)
NOSTRIN mediated translocation of eNOS from plasma membrane (Gallus gallus)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Gallus gallus)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Gallus gallus)
FMN [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Gallus gallus)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
eNOS activation (Gallus gallus)
AKT1 binds eNOS complex via HSP90 (Gallus gallus)
eNOS:CaM:HSP90 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
eNOS:CaM:HSP90 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
AKT1 phosphorylates eNOS (Gallus gallus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
eNOS:CaM:HSP90 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
BH2 binding can lead to eNOS uncoupling (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Gallus gallus)
eNOS:CaM:HSP90 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
Depalmitoylation of eNOS (Gallus gallus)
myristoylated eNOS dimer [cytosol] (Gallus gallus)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Gallus gallus)
eNOS:Caveolin-1:CaM [plasma membrane] (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
Uncoupled eNOS favours the formation of superoxide (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Gallus gallus)
myristoylated eNOS dimer [Golgi membrane] (Gallus gallus)
FMN [cytosol]
myristoylated eNOS dimer [cytosol] (Gallus gallus)
FMN [cytosol]
eNOS associates with Caveolin-1 (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
eNOS synthesizes NO (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
eNOS translocation from Golgi to Caveolae (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
Metabolism of nucleotides (Gallus gallus)
Nucleotide catabolism (Gallus gallus)
Pyrimidine catabolism (Gallus gallus)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Gallus gallus)
DPYD dimer [cytosol] (Gallus gallus)
FMN [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Gallus gallus)
DPYD dimer [cytosol] (Gallus gallus)
FMN [cytosol]
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of cofactors (Gallus gallus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Gallus gallus)
BH2 binding can lead to eNOS uncoupling (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
Metabolism of water-soluble vitamins and cofactors (Gallus gallus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Gallus gallus)
Cobalamin (Cbl) metabolism (Gallus gallus)
MTR transfers CH3 from MeCbl to HCYS (Gallus gallus)
MTRR:MTR:MeCbl [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FMN [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Gallus gallus)
MTRR:MTR:MeCbl [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FMN [cytosol]
MTRR reduces cob(II)alamin to meCbl (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FMN [cytosol]
MTRR:MTR:MeCbl [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FMN [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Gallus gallus)
MTRR:MTR [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FMN [cytosol]
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Gallus gallus)
MTRR:MTR [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FMN [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Gallus gallus)
MTRR:MTR [cytosol] (Gallus gallus)
MTRR:FMN:FAD [cytosol] (Gallus gallus)
FMN [cytosol]
Vitamin B2 (riboflavin) metabolism (Gallus gallus)
2xTRAP hydrolyzes FMN to RIB (Gallus gallus)
FMN [cytosol]
FLAD1 phosphorylates FMN (Gallus gallus)
FMN [cytosol]
RFK:Mg2+ phosphorylates RIB (Gallus gallus)
FMN [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Gallus gallus)
FMN [cytosol]
Vitamin B5 (pantothenate) metabolism (Gallus gallus)
Coenzyme A biosynthesis (Gallus gallus)
3xPPCDC:3FMN decarboxylates PPC (Gallus gallus)
3xPPCDC:3xFMN [cytosol] (Gallus gallus)
FMN [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Gallus gallus)
2xPNPO:2xFMN oxidizes PDXP to PXLP (Gallus gallus)
2xPNPO:2xFMN [cytosol] (Gallus gallus)
FMN [cytosol]
2xPNPO:2xFMN oxidizes PXAP to PXLP (Gallus gallus)
2xPNPO:2xFMN [cytosol] (Gallus gallus)
FMN [cytosol]
Signal Transduction (Gallus gallus)
Signaling by Nuclear Receptors (Gallus gallus)
ESR-mediated signaling (Gallus gallus)
Extra-nuclear estrogen signaling (Gallus gallus)
eNOS synthesizes NO (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
VEGFR2 mediated vascular permeability (Gallus gallus)
AKT1 binds eNOS complex via HSP90 (Gallus gallus)
eNOS:CaM:HSP90 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
eNOS:CaM:HSP90 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
AKT1 phosphorylates eNOS (Gallus gallus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
eNOS:CaM:HSP90 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Gallus gallus)
eNOS:CaM:HSP90 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Gallus gallus)
eNOS:Caveolin-1:CaM [plasma membrane] (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
eNOS synthesizes NO (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Gallus gallus)
eNOS:Caveolin-1 [plasma membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Gallus gallus)
FMN [cytosol]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
PKA phosphorylates NOS3 (eNOS) on serine-633 (Homo sapiens)
p-S633-eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Homo sapiens)
p-S1177,S1179-eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Defects in vitamin and cofactor metabolism (Homo sapiens)
Defects in cobalamin (B12) metabolism (Homo sapiens)
Defective MTR causes HMAG (Homo sapiens)
Defective MTR does not transfer CH3 group from MTHF to cob(I)alamin (Homo sapiens)
MTRR:mutant MTR(cob(I)alamin) [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FMN [cytosol]
Defective MTR does not transfer CH3 group from MeCbl to HCYS (Homo sapiens)
MTRR:mutant MTR(MeCbl) [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FMN [cytosol]
Defective MTRR causes HMAE (Homo sapiens)
Defective MTRR does not convert cob(II)alamin to MeCbl (Homo sapiens)
mutant MTRR:MTR(cob(II)alamin) [cytosol] (Homo sapiens)
mutant MTRR:FMN:FAD [cytosol] (Homo sapiens)
FMN [cytosol]
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase II - Conjugation of compounds (Homo sapiens)
Methylation (Homo sapiens)
MTR transfers CH3 from MeCbl to HCYS (Homo sapiens)
MTRR:MTR:MeCbl [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FMN [cytosol]
Cytosolic iron-sulfur cluster assembly (Homo sapiens)
4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold (Homo sapiens)
NDOR1:CIAPIN1 reduced [cytosol] (Homo sapiens)
NDOR1:FAD:FMN [cytosol] (Homo sapiens)
FMN [cytosol]
NADPH reduces NDOR1:CIAPIN1 (Homo sapiens)
NDOR1:CIAPIN1 oxidized [cytosol] (Homo sapiens)
NDOR1:FAD:FMN [cytosol] (Homo sapiens)
FMN [cytosol]
NDOR1:CIAPIN1 reduced [cytosol] (Homo sapiens)
NDOR1:FAD:FMN [cytosol] (Homo sapiens)
FMN [cytosol]
Metabolism of amino acids and derivatives (Homo sapiens)
Metabolism of amine-derived hormones (Homo sapiens)
Thyroxine biosynthesis (Homo sapiens)
Diiodinated tyrosine can be deiodinated (Homo sapiens)
DEHAL1:FMN [plasma membrane] (Homo sapiens)
FMN [cytosol]
Monoiodinated tyrosine can be deiodinated (Homo sapiens)
DEHAL1:FMN [plasma membrane] (Homo sapiens)
FMN [cytosol]
Sulfur amino acid metabolism (Homo sapiens)
MTR transfers CH3 from MeCbl to HCYS (Homo sapiens)
MTRR:MTR:MeCbl [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FMN [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Homo sapiens)
NOSIP mediated eNOS trafficking (Homo sapiens)
eNOS binds NOSIP (Homo sapiens)
eNOS:NOSIP [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Homo sapiens)
eNOS:NOSIP [Golgi membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Homo sapiens)
FMN [cytosol]
eNOS:NOSIP [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
NOSTRIN mediated eNOS trafficking (Homo sapiens)
NOSTRIN mediated translocation of eNOS from plasma membrane (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Homo sapiens)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Homo sapiens)
FMN [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
eNOS:Caveolin-1 complex binds to Nostrin (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
eNOS:Caveolin-1:NOSTRIN complex [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN complex [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
eNOS activation (Homo sapiens)
AKT1 binds eNOS complex via HSP90 (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
AKT1 phosphorylates eNOS (Homo sapiens)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
BH2 binding can lead to eNOS uncoupling (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
Depalmitoylation of eNOS (Homo sapiens)
myristoylated eNOS dimer [cytosol] (Homo sapiens)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Homo sapiens)
eNOS:Caveolin-1:CaM [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
Uncoupled eNOS favours the formation of superoxide (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Homo sapiens)
myristoylated eNOS dimer [Golgi membrane] (Homo sapiens)
FMN [cytosol]
myristoylated eNOS dimer [cytosol] (Homo sapiens)
FMN [cytosol]
eNOS associates with Caveolin-1 (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
eNOS synthesizes NO (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
eNOS translocation from Golgi to Caveolae (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
Metabolism of nucleotides (Homo sapiens)
Nucleotide catabolism (Homo sapiens)
Pyrimidine catabolism (Homo sapiens)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Homo sapiens)
DPYD dimer [cytosol] (Homo sapiens)
FMN [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Homo sapiens)
DPYD dimer [cytosol] (Homo sapiens)
FMN [cytosol]
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of cofactors (Homo sapiens)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Homo sapiens)
BH2 binding can lead to eNOS uncoupling (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)
Cobalamin (Cbl) metabolism (Homo sapiens)
MTR transfers CH3 from MeCbl to HCYS (Homo sapiens)
MTRR:MTR:MeCbl [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FMN [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Homo sapiens)
MTRR:MTR:MeCbl [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FMN [cytosol]
MTRR reduces cob(II)alamin to meCbl (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FMN [cytosol]
MTRR:MTR:MeCbl [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FMN [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Homo sapiens)
MTRR:MTR [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FMN [cytosol]
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Homo sapiens)
MTRR:MTR [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FMN [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Homo sapiens)
MTRR:MTR [cytosol] (Homo sapiens)
MTRR:FMN:FAD [cytosol] (Homo sapiens)
FMN [cytosol]
Vitamin B2 (riboflavin) metabolism (Homo sapiens)
2xENPP1 hydrolyzes FAD to FMN (Homo sapiens)
FMN [cytosol]
2xTRAP hydrolyzes FMN to RIB (Homo sapiens)
FMN [cytosol]
FLAD1 phosphorylates FMN (Homo sapiens)
FMN [cytosol]
RFK:Mg2+ phosphorylates RIB (Homo sapiens)
FMN [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Homo sapiens)
FMN [cytosol]
Vitamin B5 (pantothenate) metabolism (Homo sapiens)
Coenzyme A biosynthesis (Homo sapiens)
3xPPCDC:3FMN decarboxylates PPC (Homo sapiens)
3xPPCDC:3xFMN [cytosol] (Homo sapiens)
FMN [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Homo sapiens)
2xPNPO:2xFMN oxidizes PDXP to PXLP (Homo sapiens)
2xPNPO:2xFMN [cytosol] (Homo sapiens)
FMN [cytosol]
2xPNPO:2xFMN oxidizes PXAP to PXLP (Homo sapiens)
2xPNPO:2xFMN [cytosol] (Homo sapiens)
FMN [cytosol]
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
eNOS synthesizes NO (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated vascular permeability (Homo sapiens)
AKT1 binds eNOS complex via HSP90 (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
AKT1 phosphorylates eNOS (Homo sapiens)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Homo sapiens)
eNOS:CaM:HSP90 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Homo sapiens)
eNOS:Caveolin-1:CaM [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
eNOS synthesizes NO (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Homo sapiens)
FMN [cytosol]
Cellular responses to stimuli (Mus musculus)
Cellular responses to mechanical stimuli (Mus musculus)
Response of endothelial cells to shear stress (Mus musculus)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Mus musculus)
PKA phosphorylates NOS3 (eNOS) on serine-633 (Mus musculus)
p-S633-eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Mus musculus)
p-S1177,S1179-eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
Metabolism (Mus musculus)
Biological oxidations (Mus musculus)
Phase II - Conjugation of compounds (Mus musculus)
Methylation (Mus musculus)
MTR transfers CH3 from MeCbl to HCYS (Mus musculus)
MTRR:MTR:MeCbl [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FMN [cytosol]
Metabolism of amino acids and derivatives (Mus musculus)
Metabolism of amine-derived hormones (Mus musculus)
Thyroxine biosynthesis (Mus musculus)
Diiodinated tyrosine can be deiodinated (Mus musculus)
DEHAL1:FMN [plasma membrane] (Mus musculus)
FMN [cytosol]
Monoiodinated tyrosine can be deiodinated (Mus musculus)
DEHAL1:FMN [plasma membrane] (Mus musculus)
FMN [cytosol]
Sulfur amino acid metabolism (Mus musculus)
MTR transfers CH3 from MeCbl to HCYS (Mus musculus)
MTRR:MTR:MeCbl [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FMN [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Mus musculus)
NOSIP mediated eNOS trafficking (Mus musculus)
eNOS binds NOSIP (Mus musculus)
eNOS:NOSIP [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
eNOS:NOSIP translocation from caveolae to intracellular compartments (Mus musculus)
eNOS:NOSIP [Golgi membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Mus musculus)
FMN [cytosol]
eNOS:NOSIP [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
NOSTRIN mediated eNOS trafficking (Mus musculus)
NOSTRIN mediated translocation of eNOS from plasma membrane (Mus musculus)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Mus musculus)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Mus musculus)
FMN [cytosol]
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
eNOS:Caveolin-1 complex binds to Nostrin (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
eNOS:Caveolin-1:NOSTRIN complex [plasma membrane] (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Mus musculus)
eNOS:Caveolin-1:NOSTRIN complex [plasma membrane] (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
eNOS activation (Mus musculus)
AKT1 binds eNOS complex via HSP90 (Mus musculus)
eNOS:CaM:HSP90 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
eNOS:CaM:HSP90 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
AKT1 phosphorylates eNOS (Mus musculus)
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
eNOS:CaM:HSP90 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
BH2 binding can lead to eNOS uncoupling (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Mus musculus)
eNOS:CaM:HSP90 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
Depalmitoylation of eNOS (Mus musculus)
myristoylated eNOS dimer [cytosol] (Mus musculus)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
HSP90 binds eNOS:Caveolin-1:CaM complex (Mus musculus)
eNOS:Caveolin-1:CaM [plasma membrane] (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
eNOS:Caveolin-1:CaM:HSP90 [plasma membrane] (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
Uncoupled eNOS favours the formation of superoxide (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Mus musculus)
myristoylated eNOS dimer [Golgi membrane] (Mus musculus)
FMN [cytosol]
myristoylated eNOS dimer [cytosol] (Mus musculus)
FMN [cytosol]
eNOS associates with Caveolin-1 (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
eNOS synthesizes NO (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
eNOS translocation from Golgi to Caveolae (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
eNOS:Caveolin-1 complex binds to CaM (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
eNOS:Caveolin-1:CaM [plasma membrane] (Mus musculus)
eNOS:Caveolin-1 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
Metabolism of nucleotides (Mus musculus)
Nucleotide catabolism (Mus musculus)
Pyrimidine catabolism (Mus musculus)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Mus musculus)
DPYD dimer [cytosol] (Mus musculus)
FMN [cytosol]
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Mus musculus)
DPYD dimer [cytosol] (Mus musculus)
FMN [cytosol]
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of cofactors (Mus musculus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Mus musculus)
BH2 binding can lead to eNOS uncoupling (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
Metabolism of water-soluble vitamins and cofactors (Mus musculus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Mus musculus)
Cobalamin (Cbl) metabolism (Mus musculus)
MTR transfers CH3 from MeCbl to HCYS (Mus musculus)
MTRR:MTR:MeCbl [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FMN [cytosol]
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Mus musculus)
MTRR:MTR:MeCbl [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FMN [cytosol]
MTRR:MTR:cob(I)alamin [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FMN [cytosol]
MTRR reduces cob(II)alamin to meCbl (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FMN [cytosol]
MTRR:MTR:MeCbl [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FMN [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Mus musculus)
MTRR:MTR [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FMN [cytosol]
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Mus musculus)
MTRR:MTR [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FMN [cytosol]
MTRR:MTR:cob(II)alamin [cytosol] (Mus musculus)
MTRR:MTR [cytosol] (Mus musculus)
MTRR:FMN:FAD [cytosol] (Mus musculus)
FMN [cytosol]
Vitamin B2 (riboflavin) metabolism (Mus musculus)
2xENPP1 hydrolyzes FAD to FMN (Mus musculus)
FMN [cytosol]
2xTRAP hydrolyzes FMN to RIB (Mus musculus)
FMN [cytosol]
FLAD1 phosphorylates FMN (Mus musculus)
FMN [cytosol]
RFK:Mg2+ phosphorylates RIB (Mus musculus)
FMN [cytosol]
SLC52A1,2,3 transport RIB from extracellular region to cytosol (Mus musculus)
FMN [cytosol]
Vitamin B5 (pantothenate) metabolism (Mus musculus)
Coenzyme A biosynthesis (Mus musculus)
3xPPCDC:3FMN decarboxylates PPC (Mus musculus)
3xPPCDC:3xFMN [cytosol] (Mus musculus)
FMN [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Mus musculus)
2xPNPO:2xFMN oxidizes PDXP to PXLP (Mus musculus)
2xPNPO:2xFMN [cytosol] (Mus musculus)
FMN [cytosol]
2xPNPO:2xFMN oxidizes PXAP to PXLP (Mus musculus)
2xPNPO:2xFMN [cytosol] (Mus musculus)
FMN [cytosol]
Signal Transduction (Mus musculus)
Signaling by Nuclear Receptors (Mus musculus)
ESR-mediated signaling (Mus musculus)
Extra-nuclear estrogen signaling (Mus musculus)
eNOS synthesizes NO (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
VEGFR2 mediated vascular permeability (Mus musculus)
AKT1 binds eNOS complex via HSP90 (Mus musculus)
eNOS:CaM:HSP90 [plasma membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [plasma membrane] (Mus musculus)
FMN [cytosol]
eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)