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About
What is Reactome ?
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Table of Contents
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Ca2+ [extracellular region]
Stable Identifier
R-ALL-74112
Type
Chemical Compound [SimpleEntity]
Compartment
extracellular region
Synonyms
Calcium, calcium(2+)
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Extracellular matrix organization (Bos taurus)
Degradation of the extracellular matrix (Bos taurus)
E-cadherin degradation by ADAM10, ADAM15 (Bos taurus)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
E-cadherin degradation by MMP9, KLK7 (Bos taurus)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
ECM proteoglycans (Bos taurus)
SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Bos taurus)
Ca2+ [extracellular region]
Collagen type I fibril:SPARC:Hydroxylapatitie:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Hemostasis (Bos taurus)
Cell surface interactions at the vascular wall (Bos taurus)
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Bos taurus)
PROCR:Activated protein C [plasma membrane] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Formation of Fibrin Clot (Clotting Cascade) (Bos taurus)
Common Pathway of Fibrin Clot Formation (Bos taurus)
Activated protein C binds Protein S (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated protein C cleaves Factor Va intermediate form for Factor Va (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated protein C cleaves factor VIIIa (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated protein C cleaves factor Va to factor Vi intermediate form (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor Va [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated protein C is released from PROCR (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PROCR:Activated protein C [plasma membrane] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated protein C:PROCR binds F2R (Bos taurus)
PROCR:Activated protein C [plasma membrane] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PROCR:Activated protein C:F2R [plasma membrane] (Bos taurus)
PROCR:Activated protein C [plasma membrane] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Bos taurus)
PROCR:Activated protein C [plasma membrane] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Factor Xa inhibitors binds Xa (Bos taurus)
factor Xa:Factor Xa inhibitors [plasma membrane] (Bos taurus)
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PROCR binds Protein C (Bos taurus)
PROCR(18-?):Activated protein C [extracellular region] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
SERPINA5 binds activated protein C (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
SERPINA5:Activated protein C [extracellular region] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Soluble PROCR binds activated protein C (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PROCR(18-?):Activated protein C [extracellular region] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor V -> factor Va + factor V activation peptide (Bos taurus)
Extracellular thrombin inactivating complexes [extracellular region] (Bos taurus)
SERPINA5:Activated protein C [extracellular region] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor Va [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Bos taurus)
factor Va [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Bos taurus)
Extracellular thrombin inactivating complexes [extracellular region] (Bos taurus)
SERPINA5:Activated protein C [extracellular region] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Bos taurus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Bos taurus)
Ca2+ [extracellular region]
factor XIIIa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor Xa:Factor Xa inhibitors [plasma membrane] (Bos taurus)
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Bos taurus)
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Extrinsic Pathway of Fibrin Clot Formation (Bos taurus)
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Bos taurus)
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Bos taurus)
Ca2+ [extracellular region]
factor VII -> factor VIIa (Bos taurus)
10xCbxE-F7(61-466):Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor VIIa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Bos taurus)
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Bos taurus)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Bos taurus)
Ca2+ [extracellular region]
factor VIIa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Bos taurus)
Ca2+ [extracellular region]
10xCbxE-F7(61-466):Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Intrinsic Pathway of Fibrin Clot Formation (Bos taurus)
Factor IIa inhibitors (compounds) binds IIa (Bos taurus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide) binds IIa (Bos taurus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Bos taurus)
Ca2+ [extracellular region]
factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Bos taurus)
Extracellular thrombin inactivating complexes [extracellular region] (Bos taurus)
SERPINA5:Activated protein C [extracellular region] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Bos taurus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Bos taurus)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Bos taurus)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Bos taurus)
Extracellular thrombin inactivating complexes [extracellular region] (Bos taurus)
SERPINA5:Activated protein C [extracellular region] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Bos taurus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Platelet activation, signaling and aggregation (Bos taurus)
Platelet Aggregation (Plug Formation) (Bos taurus)
Integrin signaling (Bos taurus)
Autophosphorylation of PTK2 at Y397 (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Autophosphorylation of SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Bos taurus)
Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Bos taurus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Bos taurus)
Crk binding to p130cas (Bos taurus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Thrombin binding to GP1b:IX:V (Bos taurus)
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Response to elevated platelet cytosolic Ca2+ (Bos taurus)
Platelet degranulation (Bos taurus)
Exocytosis of platelet dense granule content (Bos taurus)
Platelet dense granule content [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Thrombin signalling through proteinase activated receptors (PARs) (Bos taurus)
Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Platelet homeostasis (Bos taurus)
Platelet calcium homeostasis (Bos taurus)
Elevation of cytosolic Ca2+ levels (Bos taurus)
Cation influx mediated by TRPC3/6/7 (Bos taurus)
Cations [extracellular region]
Ca2+ [extracellular region]
P2X1-mediated entry of Ca++ from plasma (Bos taurus)
Ca2+ [extracellular region]
Reduction of cytosolic Ca++ levels (Bos taurus)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Bos taurus)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Bos taurus)
Ca2+ [extracellular region]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)
TRPC1 translocates calcium from the extracellular region to the cytosol (Bos taurus)
Ca2+ [extracellular region]
Innate Immune System (Bos taurus)
Antimicrobial peptides (Bos taurus)
INTL1 binds bacterial glycans (Bos taurus)
INTL1:bacterial glycan [extracellular region] (Bos taurus)
ITLN1 trimer:Ca2+ [extracellular region] (Bos taurus)
ITLNY1:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
ITLN1 trimer:Ca2+ [extracellular region] (Bos taurus)
ITLNY1:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Metal sequestration by antimicrobial proteins (Bos taurus)
S100A7 or S100A7A binds Zn2+ (Bos taurus)
S100A7, S100A7A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
S100A7, S100A7A:Ca2+:Zn2+ [extracellular region] (Bos taurus)
S100A7, S100A7A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
S100A8:S100A9 binds Mn2+ (Bos taurus)
S100A8:S100A9:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Bos taurus)
S100A8:S100A9:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
S100A8:S100A9 binds Zn2+ (Bos taurus)
S100A8:S100A9:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A binds bacterial phospholipids (Bos taurus)
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A:phospholipids [extracellular region] (Bos taurus)
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Complement cascade (Bos taurus)
Initial triggering of complement (Bos taurus)
Conversion of C2 into C2a and C2b (Bos taurus)
C4 activators [plasma membrane] (Bos taurus)
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Bos taurus)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Conversion of C4 into C4a and C4b (Bos taurus)
C4 activators [plasma membrane] (Bos taurus)
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Bos taurus)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Creation of C4 and C2 activators (Bos taurus)
Classical antibody-mediated complement activation (Bos taurus)
Activation of C1r (Bos taurus)
C-reactive protein pentamer:phosphocholine:C1Q [extracellular region] (Bos taurus)
C-reactive protein pentamer:phosphocholine [plasma membrane] (Bos taurus)
C-reactive protein homopentamer [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Lectin pathway of complement activation (Bos taurus)
Activation of MASPs (Bos taurus)
MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane] (Bos taurus)
FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Bos taurus)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
CL-LK binds carbohydrates on target cell surface (Bos taurus)
Ca2+ [extracellular region]
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Ficolins bind to repetitive carbohydrate structures on the target cell surface (Bos taurus)
Ficolin-1 binds to molecular patterns on the target cell surface (Bos taurus)
Ca2+ [extracellular region]
FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Ficolin-2 binds to molecular patterns on the target cell surface (Bos taurus)
Ca2+ [extracellular region]
FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Bos taurus)
Ca2+ [extracellular region]
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Regulation of Complement cascade (Bos taurus)
Thrombin, ELANE cleave C5 (Bos taurus)
Activated thrombin, (ELANE) [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Toll-like Receptor Cascades (Bos taurus)
Regulation of TLR by endogenous ligand (Bos taurus)
S100A1 binds TLR4:LY96 (Bos taurus)
S100A1 dimer:Ca(2+) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
S100A1:TLR4:LY96 [plasma membrane] (Bos taurus)
S100A1 dimer:Ca(2+) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Metabolism (Bos taurus)
Integration of energy metabolism (Bos taurus)
Regulation of insulin secretion (Bos taurus)
Calcium Influx through Voltage-gated Calcium Channels (Bos taurus)
Ca2+ [extracellular region]
Metabolism of lipids (Bos taurus)
Fatty acid metabolism (Bos taurus)
Arachidonic acid metabolism (Bos taurus)
Synthesis of 5-eicosatetraenoic acids (Bos taurus)
PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Bos taurus)
PON1,2,3:2xCa2+ dimers [extracellular region] (Bos taurus)
PON1:2xCa2+ dimer [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PON2:2xCa2+ dimer [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PON3:2xCa2+ dimer [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Phospholipid metabolism (Bos taurus)
Glycerophospholipid biosynthesis (Bos taurus)
Acyl chain remodelling of PC (Bos taurus)
PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Bos taurus)
PLA2(16) [extracellular region] (Bos taurus)
PLA2G10:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Acyl chain remodelling of PE (Bos taurus)
PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Bos taurus)
PLA2(16) [extracellular region] (Bos taurus)
PLA2G10:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Acyl chain remodelling of PG (Bos taurus)
PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Bos taurus)
PLA2(16) [extracellular region] (Bos taurus)
PLA2G10:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Acyl chain remodelling of PI (Bos taurus)
PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Bos taurus)
PLA2(15) [extracellular region] (Bos taurus)
PLA2G10:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Acyl chain remodelling of PS (Bos taurus)
PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Bos taurus)
PLA2(15) [extracellular region] (Bos taurus)
PLA2G10:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Synthesis of PA (Bos taurus)
PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Bos taurus)
PLA2(15) [extracellular region] (Bos taurus)
PLA2G10:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Metabolism of nucleotides (Bos taurus)
Nucleotide catabolism (Bos taurus)
Phosphate bond hydrolysis by NTPDase proteins (Bos taurus)
NTPDase1 hydrolyzes nucleoside diphosphates (Bos taurus)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase1 hydrolyzes nucleoside triphosphates (Bos taurus)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase2 hydrolyzes nucleoside triphosphates (Bos taurus)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside diphosphates (Bos taurus)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside triphosphates (Bos taurus)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase5 hydrolyzes nucleoside diphosphates (Bos taurus)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Bos taurus)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside diphosphates (Bos taurus)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside triphosphates (Bos taurus)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
Muscle contraction (Bos taurus)
Cardiac conduction (Bos taurus)
Ion homeostasis (Bos taurus)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Bos taurus)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Bos taurus)
Ca2+ [extracellular region]
TRPC1 translocates calcium from the extracellular region to the cytosol (Bos taurus)
Ca2+ [extracellular region]
Phase 0 - rapid depolarisation (Bos taurus)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Bos taurus)
Ca2+ [extracellular region]
Phase 2 - plateau phase (Bos taurus)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Bos taurus)
Ca2+ [extracellular region]
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter receptors and postsynaptic signal transmission (Bos taurus)
Acetylcholine binding and downstream events (Bos taurus)
Postsynaptic nicotinic acetylcholine receptors (Bos taurus)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)
Ca2+ [extracellular region]
Presynaptic nicotinic acetylcholine receptors (Bos taurus)
Highly calcium permeable nicotinic acetylcholine receptors (Bos taurus)
Activation of highly calcium permeable nicotinic acetylcholine receptors (Bos taurus)
Ca2+ [extracellular region]
Activation of NMDA receptors and postsynaptic events (Bos taurus)
Unblocking of NMDA receptors, glutamate binding and activation (Bos taurus)
Ca2+ influx into the post-synaptic cell (Bos taurus)
Ca2+ [extracellular region]
Activation of kainate receptors upon glutamate binding (Bos taurus)
Ionotropic activity of kainate receptors (Bos taurus)
Activation of Ca-permeable Kainate Receptor (Bos taurus)
Activation of Ca-permeable Kainate receptors (Bos taurus)
Ca2+ [extracellular region]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Bos taurus)
Activation of AMPA receptors (Bos taurus)
Activation of Ca permeable AMPA receptors (Bos taurus)
Ca2+ [extracellular region]
HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Bos taurus)
Ca2+ [extracellular region]
HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Bos taurus)
Ca2+ [extracellular region]
Presynaptic depolarization and calcium channel opening (Bos taurus)
Ca2+ influx through voltage gated Ca2+ channels (Bos taurus)
Ca2+ [extracellular region]
Reproduction (Bos taurus)
Fertilization (Bos taurus)
Sperm Motility And Taxes (Bos taurus)
CatSper Channel Mediated Calcium Transport (Bos taurus)
Ca2+ [extracellular region]
Sensory Perception (Bos taurus)
Visual phototransduction (Bos taurus)
The phototransduction cascade (Bos taurus)
Activation of the phototransduction cascade (Bos taurus)
cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Bos taurus)
Ca2+ [extracellular region]
Signal Transduction (Bos taurus)
Integrin signaling (Bos taurus)
Autophosphorylation of PTK2 at Y397 (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Autophosphorylation of SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Bos taurus)
Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Bos taurus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Bos taurus)
Crk binding to p130cas (Bos taurus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
MAP2K and MAPK activation (Bos taurus)
Dissociation of RAS:RAF complex (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Bos taurus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
G alpha (q) signalling events (Bos taurus)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Bos taurus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
The Ligand:GPCR:Gq complex dissociates (Bos taurus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
GPCR ligand binding (Bos taurus)
Class A/1 (Rhodopsin-like receptors) (Bos taurus)
Peptide ligand-binding receptors (Bos taurus)
Proteinase-activated receptors can bind thrombin (Bos taurus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Class C/3 (Metabotropic glutamate/pheromone receptors) (Bos taurus)
CASR binds Ca2+ (Bos taurus)
Ca2+ [extracellular region]
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases activate IQGAPs (Bos taurus)
IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Bos taurus)
CDH1 dimer:CTNNB1:CTNNA1 [plasma membrane] (Bos taurus)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
CDH1 dimer:CTTNB1:CTTNA1:IQGAP1:MEN1 [plasma membrane] (Bos taurus)
CDH1 dimer:CTNNB1:CTNNA1 [plasma membrane] (Bos taurus)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Transport of small molecules (Bos taurus)
Ion channel transport (Bos taurus)
Ion transport by P-type ATPases (Bos taurus)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Bos taurus)
Ca2+ [extracellular region]
Stimuli-sensing channels (Bos taurus)
TRP channels (Bos taurus)
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Bos taurus)
Ca2+ [extracellular region]
TRPV1 transports Ca2+ from extracellular region to cytosol (Bos taurus)
Ca2+ [extracellular region]
TRPs transport extracellular Ca2+ to cytosol (Bos taurus)
Ca2+ [extracellular region]
SLC-mediated transmembrane transport (Bos taurus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Bos taurus)
Sodium/Calcium exchangers (Bos taurus)
K+-independent Li+/Ca2+ exchanger transport (Bos taurus)
Ca2+ [extracellular region]
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Bos taurus)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Bos taurus)
Ca2+ [extracellular region]
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
Platelet Aggregation (Plug Formation) (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Autophosphorylation of PTK2 at Y397 (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Autophosphorylation of SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Caenorhabditis elegans)
Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Caenorhabditis elegans)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Response to elevated platelet cytosolic Ca2+ (Caenorhabditis elegans)
Platelet degranulation (Caenorhabditis elegans)
Exocytosis of platelet dense granule content (Caenorhabditis elegans)
Platelet dense granule content [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Platelet homeostasis (Caenorhabditis elegans)
Platelet calcium homeostasis (Caenorhabditis elegans)
Elevation of cytosolic Ca2+ levels (Caenorhabditis elegans)
Cation influx mediated by TRPC3/6/7 (Caenorhabditis elegans)
Cations [extracellular region]
Ca2+ [extracellular region]
Reduction of cytosolic Ca++ levels (Caenorhabditis elegans)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Caenorhabditis elegans)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Caenorhabditis elegans)
Ca2+ [extracellular region]
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Signaling by the B Cell Receptor (BCR) (Caenorhabditis elegans)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Caenorhabditis elegans)
TRPC1 translocates calcium from the extracellular region to the cytosol (Caenorhabditis elegans)
Ca2+ [extracellular region]
Metabolism (Caenorhabditis elegans)
Integration of energy metabolism (Caenorhabditis elegans)
Regulation of insulin secretion (Caenorhabditis elegans)
Calcium Influx through Voltage-gated Calcium Channels (Caenorhabditis elegans)
Ca2+ [extracellular region]
Metabolism of lipids (Caenorhabditis elegans)
Fatty acid metabolism (Caenorhabditis elegans)
Arachidonic acid metabolism (Caenorhabditis elegans)
Synthesis of 5-eicosatetraenoic acids (Caenorhabditis elegans)
PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Caenorhabditis elegans)
PON1,2,3:2xCa2+ dimers [extracellular region] (Caenorhabditis elegans)
PON1:2xCa2+ dimer [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PON2:2xCa2+ dimer [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PON3:2xCa2+ dimer [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Phospholipid metabolism (Caenorhabditis elegans)
Glycerophospholipid biosynthesis (Caenorhabditis elegans)
Acyl chain remodelling of PC (Caenorhabditis elegans)
PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Caenorhabditis elegans)
PLA2G12A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Acyl chain remodelling of PE (Caenorhabditis elegans)
PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Caenorhabditis elegans)
PLA2G12A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Acyl chain remodelling of PG (Caenorhabditis elegans)
PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Caenorhabditis elegans)
PLA2G12A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Acyl chain remodelling of PI (Caenorhabditis elegans)
PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Caenorhabditis elegans)
PLA2G12A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Acyl chain remodelling of PS (Caenorhabditis elegans)
PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Caenorhabditis elegans)
PLA2G12A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Synthesis of PA (Caenorhabditis elegans)
PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Caenorhabditis elegans)
PLA2G12A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Metabolism of nucleotides (Caenorhabditis elegans)
Nucleotide catabolism (Caenorhabditis elegans)
Phosphate bond hydrolysis by NTPDase proteins (Caenorhabditis elegans)
NTPDase5 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Caenorhabditis elegans)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Caenorhabditis elegans)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
Muscle contraction (Caenorhabditis elegans)
Cardiac conduction (Caenorhabditis elegans)
Ion homeostasis (Caenorhabditis elegans)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Caenorhabditis elegans)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Caenorhabditis elegans)
Ca2+ [extracellular region]
TRPC1 translocates calcium from the extracellular region to the cytosol (Caenorhabditis elegans)
Ca2+ [extracellular region]
Phase 0 - rapid depolarisation (Caenorhabditis elegans)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)
Ca2+ [extracellular region]
Phase 2 - plateau phase (Caenorhabditis elegans)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)
Ca2+ [extracellular region]
Neuronal System (Caenorhabditis elegans)
Transmission across Chemical Synapses (Caenorhabditis elegans)
Neurotransmitter receptors and postsynaptic signal transmission (Caenorhabditis elegans)
Acetylcholine binding and downstream events (Caenorhabditis elegans)
Postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)
Ca2+ [extracellular region]
Presynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)
Highly calcium permeable nicotinic acetylcholine receptors (Caenorhabditis elegans)
Activation of highly calcium permeable nicotinic acetylcholine receptors (Caenorhabditis elegans)
Ca2+ [extracellular region]
Activation of NMDA receptors and postsynaptic events (Caenorhabditis elegans)
Unblocking of NMDA receptors, glutamate binding and activation (Caenorhabditis elegans)
Ca2+ influx into the post-synaptic cell (Caenorhabditis elegans)
Ca2+ [extracellular region]
Activation of kainate receptors upon glutamate binding (Caenorhabditis elegans)
Ionotropic activity of kainate receptors (Caenorhabditis elegans)
Activation of Ca-permeable Kainate Receptor (Caenorhabditis elegans)
Activation of Ca-permeable Kainate receptors (Caenorhabditis elegans)
Ca2+ [extracellular region]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Caenorhabditis elegans)
Activation of AMPA receptors (Caenorhabditis elegans)
Activation of Ca permeable AMPA receptors (Caenorhabditis elegans)
Ca2+ [extracellular region]
HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Caenorhabditis elegans)
Ca2+ [extracellular region]
HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Caenorhabditis elegans)
Ca2+ [extracellular region]
Presynaptic depolarization and calcium channel opening (Caenorhabditis elegans)
Ca2+ influx through voltage gated Ca2+ channels (Caenorhabditis elegans)
Ca2+ [extracellular region]
Sensory Perception (Caenorhabditis elegans)
Visual phototransduction (Caenorhabditis elegans)
The phototransduction cascade (Caenorhabditis elegans)
Activation of the phototransduction cascade (Caenorhabditis elegans)
cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Caenorhabditis elegans)
Ca2+ [extracellular region]
Signal Transduction (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Autophosphorylation of PTK2 at Y397 (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Autophosphorylation of SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Caenorhabditis elegans)
Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Caenorhabditis elegans)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF/MAP kinase cascade (Caenorhabditis elegans)
MAP2K and MAPK activation (Caenorhabditis elegans)
Dissociation of RAS:RAF complex (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (q) signalling events (Caenorhabditis elegans)
The Ligand:GPCR:Gq complex dissociates (Caenorhabditis elegans)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Transport of small molecules (Caenorhabditis elegans)
Ion channel transport (Caenorhabditis elegans)
Ion transport by P-type ATPases (Caenorhabditis elegans)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Caenorhabditis elegans)
Ca2+ [extracellular region]
Stimuli-sensing channels (Caenorhabditis elegans)
TRP channels (Caenorhabditis elegans)
TRPV1 transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)
Ca2+ [extracellular region]
TRPs transport extracellular Ca2+ to cytosol (Caenorhabditis elegans)
Ca2+ [extracellular region]
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of inorganic cations/anions and amino acids/oligopeptides (Caenorhabditis elegans)
Sodium/Calcium exchangers (Caenorhabditis elegans)
K+-independent Li+/Ca2+ exchanger transport (Caenorhabditis elegans)
Ca2+ [extracellular region]
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Caenorhabditis elegans)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Caenorhabditis elegans)
Ca2+ [extracellular region]
Extracellular matrix organization (Canis familiaris)
Degradation of the extracellular matrix (Canis familiaris)
E-cadherin degradation by ADAM10, ADAM15 (Canis familiaris)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
E-cadherin degradation by MMP9, KLK7 (Canis familiaris)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
ECM proteoglycans (Canis familiaris)
SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Canis familiaris)
Ca2+ [extracellular region]
Collagen type I fibril:SPARC:Hydroxylapatitie:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Hemostasis (Canis familiaris)
Cell surface interactions at the vascular wall (Canis familiaris)
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Canis familiaris)
PROCR:Activated protein C [plasma membrane] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Formation of Fibrin Clot (Clotting Cascade) (Canis familiaris)
Common Pathway of Fibrin Clot Formation (Canis familiaris)
Activated protein C binds Protein S (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated protein C cleaves Factor Va intermediate form for Factor Va (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated protein C cleaves factor Va to factor Vi intermediate form (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor Va [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated protein C is released from PROCR (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PROCR:Activated protein C [plasma membrane] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated protein C:PROCR binds F2R (Canis familiaris)
PROCR:Activated protein C [plasma membrane] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PROCR:Activated protein C:F2R [plasma membrane] (Canis familiaris)
PROCR:Activated protein C [plasma membrane] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Canis familiaris)
PROCR:Activated protein C [plasma membrane] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Factor Xa inhibitors binds Xa (Canis familiaris)
factor Xa:Factor Xa inhibitors [plasma membrane] (Canis familiaris)
factor Xa [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PROCR binds Protein C (Canis familiaris)
PROCR(18-?):Activated protein C [extracellular region] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
SERPINA5 binds activated protein C (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
SERPINA5:Activated protein C [extracellular region] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Soluble PROCR binds activated protein C (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PROCR(18-?):Activated protein C [extracellular region] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor V -> factor Va + factor V activation peptide (Canis familiaris)
Extracellular thrombin inactivating complexes [extracellular region] (Canis familiaris)
SERPINA5:Activated protein C [extracellular region] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor Va [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Canis familiaris)
factor Va [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Canis familiaris)
Extracellular thrombin inactivating complexes [extracellular region] (Canis familiaris)
SERPINA5:Activated protein C [extracellular region] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Canis familiaris)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Canis familiaris)
Ca2+ [extracellular region]
factor XIIIa [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor Xa:Factor Xa inhibitors [plasma membrane] (Canis familiaris)
factor Xa [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Canis familiaris)
thrombin:cleaved SERPINC1 [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Intrinsic Pathway of Fibrin Clot Formation (Canis familiaris)
Factor IIa inhibitors (compounds) binds IIa (Canis familiaris)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide) binds IIa (Canis familiaris)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Platelet activation, signaling and aggregation (Canis familiaris)
Platelet Aggregation (Plug Formation) (Canis familiaris)
Integrin signaling (Canis familiaris)
Autophosphorylation of PTK2 at Y397 (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Autophosphorylation of SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Canis familiaris)
Interaction of SOS with GRB2 bound to FADK1 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Canis familiaris)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]