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Ca2+ [mitochondrial matrix]
Stable Identifier
R-ALL-8949220
Type
Chemical Compound [SimpleEntity]
Compartment
mitochondrial matrix
Synonyms
Calcium, calcium(2+)
Icon
Locations in the PathwayBrowser for interactor UniProt:P80511 S100A12
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Aerobic respiration and respiratory electron transport (Bos taurus)
Citric acid cycle (TCA cycle) (Bos taurus)
OGDH complex synthesizes succinyl-CoA from 2-OG (Bos taurus)
OGDH dimer decarboxylates 2-OG (Bos taurus)
Ca2+ [mitochondrial matrix]
Transport of small molecules (Bos taurus)
Mitochondrial calcium ion transport (Bos taurus)
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Bos taurus)
Ca2+ [mitochondrial matrix]
SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Bos taurus)
Ca2+ [mitochondrial matrix]
Metabolism (Caenorhabditis elegans)
Aerobic respiration and respiratory electron transport (Caenorhabditis elegans)
Citric acid cycle (TCA cycle) (Caenorhabditis elegans)
OGDH complex synthesizes succinyl-CoA from 2-OG (Caenorhabditis elegans)
OGDH dimer decarboxylates 2-OG (Caenorhabditis elegans)
Ca2+ [mitochondrial matrix]
Transport of small molecules (Caenorhabditis elegans)
Mitochondrial calcium ion transport (Caenorhabditis elegans)
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Caenorhabditis elegans)
Ca2+ [mitochondrial matrix]
SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Caenorhabditis elegans)
Ca2+ [mitochondrial matrix]
Metabolism (Canis familiaris)
Aerobic respiration and respiratory electron transport (Canis familiaris)
Citric acid cycle (TCA cycle) (Canis familiaris)
OGDH complex synthesizes succinyl-CoA from 2-OG (Canis familiaris)
OGDH dimer decarboxylates 2-OG (Canis familiaris)
Ca2+ [mitochondrial matrix]
Transport of small molecules (Canis familiaris)
Mitochondrial calcium ion transport (Canis familiaris)
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Canis familiaris)
Ca2+ [mitochondrial matrix]
SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Canis familiaris)
Ca2+ [mitochondrial matrix]
Metabolism (Danio rerio)
Aerobic respiration and respiratory electron transport (Danio rerio)
Citric acid cycle (TCA cycle) (Danio rerio)
OGDH complex synthesizes succinyl-CoA from 2-OG (Danio rerio)
OGDH dimer decarboxylates 2-OG (Danio rerio)
Ca2+ [mitochondrial matrix]
Metabolism (Dictyostelium discoideum)
Aerobic respiration and respiratory electron transport (Dictyostelium discoideum)
Citric acid cycle (TCA cycle) (Dictyostelium discoideum)
OGDH complex synthesizes succinyl-CoA from 2-OG (Dictyostelium discoideum)
OGDH dimer decarboxylates 2-OG (Dictyostelium discoideum)
Ca2+ [mitochondrial matrix]
Transport of small molecules (Dictyostelium discoideum)
Mitochondrial calcium ion transport (Dictyostelium discoideum)
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Dictyostelium discoideum)
Ca2+ [mitochondrial matrix]
Metabolism (Drosophila melanogaster)
Aerobic respiration and respiratory electron transport (Drosophila melanogaster)
Citric acid cycle (TCA cycle) (Drosophila melanogaster)
OGDH complex synthesizes succinyl-CoA from 2-OG (Drosophila melanogaster)
OGDH dimer decarboxylates 2-OG (Drosophila melanogaster)
Ca2+ [mitochondrial matrix]
Transport of small molecules (Drosophila melanogaster)
Mitochondrial calcium ion transport (Drosophila melanogaster)
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Drosophila melanogaster)
Ca2+ [mitochondrial matrix]
SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Drosophila melanogaster)
Ca2+ [mitochondrial matrix]
Metabolism (Gallus gallus)
Aerobic respiration and respiratory electron transport (Gallus gallus)
Citric acid cycle (TCA cycle) (Gallus gallus)
OGDH complex synthesizes succinyl-CoA from 2-OG (Gallus gallus)
OGDH dimer decarboxylates 2-OG (Gallus gallus)
Ca2+ [mitochondrial matrix]
Transport of small molecules (Gallus gallus)
Mitochondrial calcium ion transport (Gallus gallus)
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Gallus gallus)
Ca2+ [mitochondrial matrix]
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Citric acid cycle (TCA cycle) (Homo sapiens)
OGDH complex synthesizes succinyl-CoA from 2-OG (Homo sapiens)
OGDH dimer decarboxylates 2-OG (Homo sapiens)
Ca2+ [mitochondrial matrix]
Transport of small molecules (Homo sapiens)
Mitochondrial calcium ion transport (Homo sapiens)
LETM1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Homo sapiens)
Ca2+ [mitochondrial matrix]
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)
Ca2+ [mitochondrial matrix]
SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Homo sapiens)
Ca2+ [mitochondrial matrix]
Metabolism (Mus musculus)
Aerobic respiration and respiratory electron transport (Mus musculus)
Citric acid cycle (TCA cycle) (Mus musculus)
OGDH complex synthesizes succinyl-CoA from 2-OG (Mus musculus)
OGDH dimer decarboxylates 2-OG (Mus musculus)
Ca2+ [mitochondrial matrix]
Transport of small molecules (Mus musculus)
Mitochondrial calcium ion transport (Mus musculus)
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Mus musculus)
Ca2+ [mitochondrial matrix]
SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Mus musculus)
Ca2+ [mitochondrial matrix]
Metabolism (Plasmodium falciparum)
Aerobic respiration and respiratory electron transport (Plasmodium falciparum)
Citric acid cycle (TCA cycle) (Plasmodium falciparum)
OGDH complex synthesizes succinyl-CoA from 2-OG (Plasmodium falciparum)
OGDH dimer decarboxylates 2-OG (Plasmodium falciparum)
Ca2+ [mitochondrial matrix]
Metabolism (Rattus norvegicus)
Aerobic respiration and respiratory electron transport (Rattus norvegicus)
Citric acid cycle (TCA cycle) (Rattus norvegicus)
OGDH complex synthesizes succinyl-CoA from 2-OG (Rattus norvegicus)
OGDH dimer decarboxylates 2-OG (Rattus norvegicus)
Ca2+ [mitochondrial matrix]
Transport of small molecules (Rattus norvegicus)
Mitochondrial calcium ion transport (Rattus norvegicus)
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Rattus norvegicus)
Ca2+ [mitochondrial matrix]
SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Rattus norvegicus)
Ca2+ [mitochondrial matrix]
Metabolism (Saccharomyces cerevisiae)
Aerobic respiration and respiratory electron transport (Saccharomyces cerevisiae)
Citric acid cycle (TCA cycle) (Saccharomyces cerevisiae)
OGDH complex synthesizes succinyl-CoA from 2-OG (Saccharomyces cerevisiae)
OGDH dimer decarboxylates 2-OG (Saccharomyces cerevisiae)
Ca2+ [mitochondrial matrix]
Transport of small molecules (Saccharomyces cerevisiae)
Mitochondrial calcium ion transport (Saccharomyces cerevisiae)
SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Saccharomyces cerevisiae)
Ca2+ [mitochondrial matrix]
Metabolism (Schizosaccharomyces pombe)
Aerobic respiration and respiratory electron transport (Schizosaccharomyces pombe)
Citric acid cycle (TCA cycle) (Schizosaccharomyces pombe)
OGDH complex synthesizes succinyl-CoA from 2-OG (Schizosaccharomyces pombe)
OGDH dimer decarboxylates 2-OG (Schizosaccharomyces pombe)
Ca2+ [mitochondrial matrix]
Transport of small molecules (Schizosaccharomyces pombe)
Mitochondrial calcium ion transport (Schizosaccharomyces pombe)
SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Schizosaccharomyces pombe)
Ca2+ [mitochondrial matrix]
Metabolism (Sus scrofa)
Aerobic respiration and respiratory electron transport (Sus scrofa)
Citric acid cycle (TCA cycle) (Sus scrofa)
OGDH complex synthesizes succinyl-CoA from 2-OG (Sus scrofa)
OGDH dimer decarboxylates 2-OG (Sus scrofa)
Ca2+ [mitochondrial matrix]
Transport of small molecules (Sus scrofa)
Mitochondrial calcium ion transport (Sus scrofa)
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Sus scrofa)
Ca2+ [mitochondrial matrix]
SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Sus scrofa)
Ca2+ [mitochondrial matrix]
Metabolism (Xenopus tropicalis)
Aerobic respiration and respiratory electron transport (Xenopus tropicalis)
Citric acid cycle (TCA cycle) (Xenopus tropicalis)
OGDH complex synthesizes succinyl-CoA from 2-OG (Xenopus tropicalis)
OGDH dimer decarboxylates 2-OG (Xenopus tropicalis)
Ca2+ [mitochondrial matrix]
Transport of small molecules (Xenopus tropicalis)
Mitochondrial calcium ion transport (Xenopus tropicalis)
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Xenopus tropicalis)
Ca2+ [mitochondrial matrix]
External Reference Information
External Reference
calcium(2+) [ChEBI:29108]
Participates
as a component of
alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Mus musculus)
SLC25A13:Ca2+ [mitochondrial inner membrane] (Mus musculus)
SLC25A12:Ca2+ [mitochondrial inner membrane] (Mus musculus)
alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Rattus norvegicus)
alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Bos taurus)
SLC25A12:Ca2+ [mitochondrial inner membrane] (Bos taurus)
SLC25A13:Ca2+ [mitochondrial inner membrane] (Bos taurus)
SLC25A12:Ca2+ [mitochondrial inner membrane] (Homo sapiens)
SLC25A12:Ca2+ [mitochondrial inner membrane] (Xenopus tropicalis)
SLC25A12:Ca2+ [mitochondrial inner membrane] (Drosophila melanogaster)
SLC25A12:Ca2+ [mitochondrial inner membrane] (Sus scrofa)
SLC25A12:Ca2+ [mitochondrial inner membrane] (Dictyostelium discoideum)
SLC25A12:Ca2+ [mitochondrial inner membrane] (Saccharomyces cerevisiae)
SLC25A12:Ca2+ [mitochondrial inner membrane] (Rattus norvegicus)
SLC25A12:Ca2+ [mitochondrial inner membrane] (Caenorhabditis elegans)
SLC25A12:Ca2+ [mitochondrial inner membrane] (Canis familiaris)
SLC25A12:Ca2+ [mitochondrial inner membrane] (Danio rerio)
SLC25A12:Ca2+ [mitochondrial inner membrane] (Gallus gallus)
SLC25A13:Ca2+ [mitochondrial inner membrane] (Homo sapiens)
SLC25A13:Ca2+ [mitochondrial inner membrane] (Rattus norvegicus)
SLC25A13:Ca2+ [mitochondrial inner membrane] (Gallus gallus)
SLC25A13:Ca2+ [mitochondrial inner membrane] (Dictyostelium discoideum)
SLC25A13:Ca2+ [mitochondrial inner membrane] (Drosophila melanogaster)
SLC25A13:Ca2+ [mitochondrial inner membrane] (Saccharomyces cerevisiae)
SLC25A13:Ca2+ [mitochondrial inner membrane] (Canis familiaris)
SLC25A13:Ca2+ [mitochondrial inner membrane] (Xenopus tropicalis)
SLC25A13:Ca2+ [mitochondrial inner membrane] (Caenorhabditis elegans)
SLC25A13:Ca2+ [mitochondrial inner membrane] (Sus scrofa)
alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Canis familiaris)
alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Sus scrofa)
alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Homo sapiens)
alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Gallus gallus)
alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Caenorhabditis elegans)
alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Saccharomyces cerevisiae)
alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Xenopus tropicalis)
alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Drosophila melanogaster)
alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Danio rerio)
alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Dictyostelium discoideum)
alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Schizosaccharomyces pombe)
alpha-ketoglutarate dehydrogenase E1 holoenzyme [mitochondrial matrix] (Plasmodium falciparum)
as an input of
Letm1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Mus musculus)
LETM1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Homo sapiens)
SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Saccharomyces cerevisiae)
SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Schizosaccharomyces pombe)
SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Caenorhabditis elegans)
SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Drosophila melanogaster)
SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Sus scrofa)
SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Bos taurus)
SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Canis familiaris)
SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Homo sapiens)
SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Mus musculus)
SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Rattus norvegicus)
as an output of
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Dictyostelium discoideum)
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Caenorhabditis elegans)
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Drosophila melanogaster)
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Gallus gallus)
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Xenopus tropicalis)
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Sus scrofa)
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Bos taurus)
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Canis familiaris)
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Rattus norvegicus)
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Mus musculus)
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)
This entity regulates
Negatively
OGDH dimer decarboxylates 2-OG
(Plasmodium falciparum)
OGDH dimer decarboxylates 2-OG
(Dictyostelium discoideum)
OGDH dimer decarboxylates 2-OG
(Saccharomyces cerevisiae)
OGDH dimer decarboxylates 2-OG
(Schizosaccharomyces pombe)
OGDH dimer decarboxylates 2-OG
(Caenorhabditis elegans)
OGDH dimer decarboxylates 2-OG
(Drosophila melanogaster)
OGDH dimer decarboxylates 2-OG
(Gallus gallus)
OGDH dimer decarboxylates 2-OG
(Xenopus tropicalis)
OGDH dimer decarboxylates 2-OG
(Danio rerio)
OGDH dimer decarboxylates 2-OG
(Sus scrofa)
OGDH dimer decarboxylates 2-OG
(Canis familiaris)
OGDH dimer decarboxylates 2-OG
(Bos taurus)
OGDH dimer decarboxylates 2-OG
(Rattus norvegicus)
OGDH dimer decarboxylates 2-OG
(Mus musculus)
OGDH dimer decarboxylates 2-OG
(Homo sapiens)
Other forms of this molecule
Ca2+ [platelet dense granule lumen]
Ca2+ [endosome membrane]
Ca2+ [sarcoplasmic reticulum lumen]
Ca2+ [mitochondrial intermembrane space]
Ca2+ [lysosomal lumen]
Ca2+ [endocytic vesicle lumen]
Ca2+ [endoplasmic reticulum-Golgi intermediate compartment]
Ca2+ [Golgi lumen]
Ca2+ [platelet dense tubular network lumen]
Ca2+ [platelet dense tubular network membrane]
Ca2+ [plasma membrane]
Ca2+ [secretory granule lumen]
Ca2+ [nuclear envelope]
Ca2+ [nucleoplasm]
Ca2+ [mitochondrial inner membrane]
Ca2+ [endoplasmic reticulum membrane]
Ca2+ [cytosol]
Ca2+ [extracellular region]
Ca2+ [endoplasmic reticulum lumen]
Cross References
COMPOUND
C00076
PubChem Substance
8145461
HMDB Metabolite
HMDB0000464
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![Ca2+ [mitochondrial matrix] icon](/icon/R-ICO-012501.svg){kind=icon}
