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trastuzumab [extracellular region]
Stable Identifier
R-ALL-9634466
Type
ProteinDrug
Compartment
extracellular region
Synonyms
herceptin, D5v8, R-597
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Caenorhabditis elegans
Danio rerio
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Xenopus tropicalis
Expand all
Signal Transduction (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by ERBB2 (Caenorhabditis elegans)
Trans-autophosphorylation of ERBB2 heterodimers (Caenorhabditis elegans)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Caenorhabditis elegans)
ERBB2:trastuzumab [plasma membrane] (Caenorhabditis elegans)
trastuzumab [extracellular region]
Signal Transduction (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by ERBB2 (Danio rerio)
Trans-autophosphorylation of ERBB2 heterodimers (Danio rerio)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Danio rerio)
ERBB2:trastuzumab [plasma membrane] (Danio rerio)
trastuzumab [extracellular region]
Signal Transduction (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by ERBB2 (Drosophila melanogaster)
Trans-autophosphorylation of ERBB2 heterodimers (Drosophila melanogaster)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Drosophila melanogaster)
ERBB2:trastuzumab [plasma membrane] (Drosophila melanogaster)
trastuzumab [extracellular region]
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ERBB2 (Gallus gallus)
Trans-autophosphorylation of ERBB2 heterodimers (Gallus gallus)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Gallus gallus)
ERBB2:trastuzumab [plasma membrane] (Gallus gallus)
trastuzumab [extracellular region]
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ERBB2 in Cancer (Homo sapiens)
Constitutive Signaling by Overexpressed ERBB2 (Homo sapiens)
ERBB2 binds trastuzumab (Homo sapiens)
trastuzumab [extracellular region]
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:trastuzumab [plasma membrane] (Homo sapiens)
trastuzumab [extracellular region]
Trans-autophosphorylation of ERBB2 homodimer (Homo sapiens)
trastuzumab [extracellular region]
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:trastuzumab [plasma membrane] (Homo sapiens)
trastuzumab [extracellular region]
Drug resistance in ERBB2 KD mutants (Homo sapiens)
Resistance of ERBB2 KD mutants to trastuzumab (Homo sapiens)
Resistant ERBB2 KD mutants do not bind trastuzumab (Homo sapiens)
trastuzumab [extracellular region]
Signaling by ERBB2 ECD mutants (Homo sapiens)
ERBB2 ECD mutants bind trastuzumab (Homo sapiens)
trastuzumab [extracellular region]
ERBB2 ECD mutants:ERBIN:HSP90:CDC37:trastuzumab [plasma membrane] (Homo sapiens)
trastuzumab [extracellular region]
Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate (Homo sapiens)
trastuzumab [extracellular region]
ERBB2 ECD mutants:ERBIN:HSP90:CDC37:trastuzumab [plasma membrane] (Homo sapiens)
trastuzumab [extracellular region]
Signaling by ERBB2 KD Mutants (Homo sapiens)
ERBB2 KD mutants bind trastuzumab (Homo sapiens)
trastuzumab [extracellular region]
ERBB2 KD mutants (trastuzumab sensitive):trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (trastuzumab sensitive):trastuzumab [plasma membrane] (Homo sapiens)
trastuzumab [extracellular region]
ERBB2 KD mutants trans-autophosphorylate (Homo sapiens)
trastuzumab [extracellular region]
ERBB2 KD mutants (trastuzumab sensitive):trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (trastuzumab sensitive):trastuzumab [plasma membrane] (Homo sapiens)
trastuzumab [extracellular region]
Signaling by ERBB2 TMD/JMD mutants (Homo sapiens)
ERBB2 TMD/JMD mutants bind trastuzumab (Homo sapiens)
trastuzumab [extracellular region]
ERBB2 TMD/JMD mutants (trastuzumab):trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 TMD/JMD mutants (trastuzumab):trastuzumab [plasma membrane] (Homo sapiens)
trastuzumab [extracellular region]
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
Drug-mediated inhibition of ERBB2 signaling (Homo sapiens)
ERBB2 binds trastuzumab (Homo sapiens)
trastuzumab [extracellular region]
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:trastuzumab [plasma membrane] (Homo sapiens)
trastuzumab [extracellular region]
Trans-autophosphorylation of ERBB2 heterodimers (Homo sapiens)
trastuzumab [extracellular region]
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:trastuzumab [plasma membrane] (Homo sapiens)
trastuzumab [extracellular region]
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ERBB2 (Mus musculus)
Trans-autophosphorylation of ERBB2 heterodimers (Mus musculus)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Mus musculus)
ERBB2:trastuzumab [plasma membrane] (Mus musculus)
trastuzumab [extracellular region]
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by ERBB2 (Rattus norvegicus)
Trans-autophosphorylation of ERBB2 heterodimers (Rattus norvegicus)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Rattus norvegicus)
ERBB2:trastuzumab [plasma membrane] (Rattus norvegicus)
trastuzumab [extracellular region]
Signal Transduction (Xenopus tropicalis)
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by ERBB2 (Xenopus tropicalis)
Trans-autophosphorylation of ERBB2 heterodimers (Xenopus tropicalis)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Xenopus tropicalis)
ERBB2:trastuzumab [plasma membrane] (Xenopus tropicalis)
trastuzumab [extracellular region]
Participant Of
input
ERBB2 binds trastuzumab
ERBB2 ECD mutants bind trastuzumab
ERBB2 KD mutants bind trastuzumab
ERBB2 TMD/JMD mutants bind trastuzumab
Resistant ERBB2 KD mutants do not bind trastuzumab
hasComponent
ERBB2 ECD mutants:ERBIN:HSP90:CDC37:trastuzumab [plasma membrane]
ERBB2 KD mutants (trastuzumab sensitive):trastuzumab [plasma membrane]
ERBB2 TMD/JMD mutants (trastuzumab):trastuzumab [plasma membrane]
ERBB2:trastuzumab [plasma membrane]
ERBB2:trastuzumab [plasma membrane]
ERBB2:trastuzumab [plasma membrane]
ERBB2:trastuzumab [plasma membrane]
ERBB2:trastuzumab [plasma membrane]
ERBB2:trastuzumab [plasma membrane]
ERBB2:trastuzumab [plasma membrane]
ERBB2:trastuzumab [plasma membrane]
Disease
Name
Identifier
Synonyms
cancer
162
malignant tumor, malignant neoplasm, primary cancer
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