Reactome | CHEK2 [nucleoplasm]

CHEK2 [nucleoplasm]

Stable Identifier

R-BTA-113824

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

CHEK2, F6R5E4

Locations in the PathwayBrowser

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Cell Cycle (Bos taurus)

- Cell Cycle Checkpoints (Bos taurus)
  - G2/M Checkpoints (Bos taurus)
    - G2/M DNA damage checkpoint (Bos taurus)
      - CHEK2 is recruited to DNA DSBs (Bos taurus)
        
        CHEK2 [nucleoplasm] (Bos taurus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Bos taurus)
        
        CHEK2 [nucleoplasm] (Bos taurus)
      - Phosphorylation and activation of CHEK2 by ATM (Bos taurus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Bos taurus)
        
        CHEK2 [nucleoplasm] (Bos taurus)

DNA Repair (Bos taurus)

- DNA Double-Strand Break Repair (Bos taurus)
  - DNA Double Strand Break Response (Bos taurus)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Bos taurus)
      - CHEK2 is recruited to DNA DSBs (Bos taurus)
        
        CHEK2 [nucleoplasm] (Bos taurus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Bos taurus)
        
        CHEK2 [nucleoplasm] (Bos taurus)
      - Phosphorylation and activation of CHEK2 by ATM (Bos taurus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Bos taurus)
        
        CHEK2 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:F6R5E4

Gene Names

CHEK2

Reference Genes

ENSEMBL:ENSBTAG00000004956.4

ENSEMBL:ENSBTAG00000004956.5 CHEK2

Other Identifiers

GO:0000278

GO:0003824

GO:0004672

GO:0004674

GO:0005524

GO:0005634

GO:0005737

GO:0016740

GO:0023052

GO:0043226

GO:0044773

GO:0140096

Participates

as an input of

CHEK2 is recruited to DNA DSBs (Bos taurus)

as a component of

DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Bos taurus)

Other forms of this molecule

phospho-CHEK2 [nucleoplasm]

Inferred From

CHEK2 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000183765

Ensembl

ENSBTAP00000006518, ENSBTAG00000004956, ENSBTAT00000006518

VGNC

27286

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