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About
What is Reactome ?
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KLB [plasma membrane]
Stable Identifier
R-BTA-1307932
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
plasma membrane
Synonyms
KLB, F1N4S9
Locations in the PathwayBrowser
Expand all
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
RAS GEFs promote RAS nucleotide exchange (Bos taurus)
RAS GEFs [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS3 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
Activated FGFR4:pY-SHC1 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by FGFR (Bos taurus)
Signaling by FGFR4 (Bos taurus)
Downstream signaling of activated FGFR4 (Bos taurus)
FRS-mediated FGFR4 signaling (Bos taurus)
Activated FGFR4 binds FRS2 (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4 binds FRS3 (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:FRS3 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4 phosphorylates FRS2 (Bos taurus)
Activated FGFR4:FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-8T-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4 phosphorylates FRS3 (Bos taurus)
Activated FGFR4:FRS3 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS3 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4 phosphorylates PPTN11 (Bos taurus)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS3 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS3 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS bind to PPTN11 (Bos taurus)
Activated FGFR4:p-FRS [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS3 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS3 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS binds GRB2:SOS1 (Bos taurus)
Activated FGFR4:p-FRS [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS3 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS3 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS3 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS3 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
PI-3K cascade:FGFR4 (Bos taurus)
Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Phospholipase C-mediated cascade; FGFR4 (Bos taurus)
Activated FGFR4 binds PLCG1 (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
activated FGFR4:PLCG1 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4 phosphorylates PLCG1 (Bos taurus)
activated FGFR4:PLCG1 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
p-4Y-PLCG1 dissociates from activated FGFR4 (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
SHC-mediated cascade:FGFR4 (Bos taurus)
Activated FGFR4 binds SHC1 (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:SHC1 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4 phosphorylates SHC1 (Bos taurus)
Activated FGFR4:SHC1 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:pY-SHC1 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Bos taurus)
Activated FGFR4:pY-SHC1 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
Activated FGFR4:pY-SHC1 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
Activated FGFR4:pY-SHC1 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
FGFR4 ligand binding and activation (Bos taurus)
betaKlotho-mediated ligand binding (Bos taurus)
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
FGFR4:HS:KLB:FGF19 [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
FGFR4 binds HS:KLB:FGF19 (Bos taurus)
FGFR4:HS:KLB:FGF19 [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Negative regulation of FGFR4 signaling (Bos taurus)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Bos taurus)
Activated FGFR4:FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-8T-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
CBL ubiquitinates FRS2 and FGFR4 (Bos taurus)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Bos taurus)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR4:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR4 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Signaling by Insulin receptor (Bos taurus)
Insulin receptor signalling cascade (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI3K-containing complexes [cytosol] (Bos taurus)
Activated FGFR bound to PI3K [cytosol] (Bos taurus)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Bos taurus)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Bos taurus)
IGF1R signaling cascade (Bos taurus)
IRS-related events triggered by IGF1R (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI3K-containing complexes [cytosol] (Bos taurus)
Activated FGFR bound to PI3K [cytosol] (Bos taurus)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Bos taurus)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Bos taurus)
Activated FGFR:p-FRS2 [plasma membrane] (Bos taurus)
Activated FGFR [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Bos taurus)
External Reference Information
External Reference
UniProt:F1N4S9
Gene Names
KLB
Reference Genes
BioGPS Gene:514925 KLB
ENSEMBL:ENSBTAG00000014517.6
KEGG Gene (Bos taurus):514925 KLB
Monarch:514925 KLB
NCBI Gene:514925 KLB
Reference Transcript
RefSeq:NM_001205326.1 KLB
Other Identifiers
514925
GO:0003824
GO:0004553
GO:0005104
GO:0005975
GO:0008284
GO:0008543
GO:0016020
GO:0016787
GO:0017134
GO:0023052
GO:0090080
Participates
as an input of
FGFR4 binds HS:KLB:FGF19 (Bos taurus)
as a component of
FGFR4:HS:KLB:FGF19 [plasma membrane] (Bos taurus)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Bos taurus)
Inferred From
KLB [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
NP_001192255.1
OpenTargets
ENSG00000134962
Ensembl
ENSBTAT00000019297
,
ENSBTAG00000014517
,
ENSBTAP00000019297
VGNC
30622
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