Reactome | MLST8 [cytosol]

MLST8 [cytosol]

Stable Identifier

R-BTA-165676

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

MLST8, Q17QU5

Locations in the PathwayBrowser

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Autophagy (Bos taurus)

- Macroautophagy (Bos taurus)
  - Active MTORC1 binds the ULK1 complex (Bos taurus)
    - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Bos taurus)
      - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
  - Active MTORC1 phosphorylates ULK1 (Bos taurus)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Bos taurus)
      - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Bos taurus)
      - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
  - MTORC1 dissociates from ULK complex (Bos taurus)
    - MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Bos taurus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Bos taurus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Bos taurus)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
    - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Bos taurus)
      - mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Bos taurus)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
  - Rheb in the MTORC1 complex hydrolyses GTP (Bos taurus)
    - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
    - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Bos taurus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Bos taurus)
    - MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Bos taurus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Bos taurus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Bos taurus)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Bos taurus)
      - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)

Cellular responses to stimuli (Bos taurus)

- Cellular responses to stress (Bos taurus)
  - Cellular response to starvation (Bos taurus)
    - Amino acids regulate mTORC1 (Bos taurus)
      - RRAGA,B hydrolyzes GTP (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
      - mTORC1 binds RHEB:GTP (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)

Gene expression (Transcription) (Bos taurus)

- RNA Polymerase II Transcription (Bos taurus)
  - Generic Transcription Pathway (Bos taurus)
    - Transcriptional Regulation by TP53 (Bos taurus)
      - TP53 Regulates Metabolic Genes (Bos taurus)
        
        RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Bos taurus)
        
        Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
        
        mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)

Signal Transduction (Bos taurus)

- Intracellular signaling by second messengers (Bos taurus)
  - PIP3 activates AKT signaling (Bos taurus)
    - PTEN Regulation (Bos taurus)
      - Regulation of PTEN gene transcription (Bos taurus)
        
        MAF1 translocates to the nucleus (Bos taurus)
        
        Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
        
        mTORC1 phosphorylates MAF1 (Bos taurus)
        
        Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
- MTOR signalling (Bos taurus)
  - AKT1S1 (PRAS40) binds mTORC1 (Bos taurus)
    - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Bos taurus)
      - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
  - Energy dependent regulation of mTOR by LKB1-AMPK (Bos taurus)
    - AMPK phosphorylates Raptor in the mTORC1 complex (Bos taurus)
      - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Bos taurus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Bos taurus)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
    - RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Bos taurus)
      - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
      - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
  - Formation of active mTORC1 complex (Bos taurus)
    - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
      - mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
  - Phosphorylated AKT1S1:mTORC1 binds YWHAB (Bos taurus)
    - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Bos taurus)
      - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Bos taurus)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Bos taurus)
        
        Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
  - Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Bos taurus)
    - mTORC1 [cytosol] (Bos taurus)
      - MLST8 [cytosol] (Bos taurus)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
      - mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
  - mTORC1 phosphorylates AKT1S1 (Bos taurus)
    - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB [lysosomal membrane] (Bos taurus)
      - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1 [lysosomal membrane] (Bos taurus)
        
        Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Bos taurus)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Bos taurus)
        
        Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
  - mTORC1-mediated signalling (Bos taurus)
    - Phosphorylation of 4E-BP1 by activated mTORC1 (Bos taurus)
      - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
      - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Bos taurus)
        
        Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Bos taurus)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Bos taurus)
        
        Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
    - mTORC1 phosphorylation of RPS6KB1 (S6K) (Bos taurus)
      - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Bos taurus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Bos taurus)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Bos taurus)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Bos taurus)
        
        Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        mTORC1 [cytosol] (Bos taurus)
        
        MLST8 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:Q17QU5

Gene Names

MLST8

Reference Genes

BioGPS Gene:535236 MLST8

ENSEMBL:ENSBTAG00000009928

KEGG Gene (Bos taurus):535236 MLST8

Monarch:535236 MLST8

NCBI Gene:535236 MLST8

Reference Transcript

Other Identifiers

GO:0005737

GO:0005764

GO:0005765

GO:0005773

GO:0007010

GO:0016020

GO:0023052

GO:0030838

GO:0031929

GO:0031931

GO:0031932

GO:0032008

GO:0032956

GO:0036211

GO:0038202

GO:0043226

GO:0043539

GO:0050731

GO:0065003

GO:0098772

Participates

as a component of

Other forms of this molecule

MLST8 [nucleoplasm]

Inferred From

MLST8 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005224583.1, NP_001030488.1

OpenTargets

ENSG00000167965

Ensembl

ENSBTAP00000048491, ENSBTAG00000009928, ENSBTAP00000013104, ENSBTAT00000013104, ENSBTAT00000053181

VGNC

31507

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