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MYD88 [cytosol]
Stable Identifier
R-BTA-166059
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
MYD88, A0A452DHW6
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 signaling (Bos taurus)
Hyperphosphorylated IRAK1 associates with TRAF6 (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
IL1R1:IL1:IL1RAP binds MYD88 homodimer (Bos taurus)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Bos taurus)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
IRAK1 binds to MYD88 within the IL1R complex (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
IRAK4 is activated by autophosphorylation (Bos taurus)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
IRAK4 phosphorylates IRAK1 (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
IRAK4-activated IRAK1 autophosphorylates (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
TRAF6 binding leads to IRAK1:TRAF6 release (Bos taurus)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
The Interleukin 1 receptor complex binds Tollip (Bos taurus)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Bos taurus)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
Cytosolic sensors of pathogen-associated DNA (Bos taurus)
DEx/H-box helicases activate type I IFN and inflammatory cytokines production (Bos taurus)
DHX36 or DHX9 binds MyD88 (Bos taurus)
DHX9/DHX36:CpG:MyD88 [cytosol] (Bos taurus)
DHX36:CpG:MyD88 [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
DHX9:CpG:MyD88 [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
NFkB complex translocates from the cytosol to the nucleus (Bos taurus)
DHX9:CpG:MyD88 [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
p-IRF7:p-IRF7 translocates to the nucleus (Bos taurus)
DHX36:CpG:MyD88 [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
ZBP1(DAI) mediated induction of type I IFNs (Bos taurus)
RIP-mediated NFkB activation via ZBP1 (Bos taurus)
NFkB complex translocates from the cytosol to the nucleus (Bos taurus)
DHX9:CpG:MyD88 [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
p75 NTR receptor-mediated signalling (Bos taurus)
p75NTR signals via NF-kB (Bos taurus)
p75NTR recruits signalling complexes (Bos taurus)
IRAK interacts with TRAF6 (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
MYD88 dissociates (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Bos taurus)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Bos taurus)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
MYD88 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:A0A452DHW6
Gene Names
MYD88
Reference Genes
ENSEMBL:ENSBTAG00000000563.6
UCSC:A0A452DHW6 MYD88
Other Identifiers
GO:0002238
GO:0002269
GO:0002283
GO:0002376
GO:0002755
GO:0003824
GO:0005149
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006325
GO:0006355
GO:0006909
GO:0006915
GO:0006954
GO:0007166
GO:0007254
GO:0009615
GO:0009682
GO:0009986
GO:0010467
GO:0010468
GO:0010628
GO:0012501
GO:0014004
GO:0016064
GO:0016192
GO:0019897
GO:0022008
GO:0030154
GO:0031234
GO:0031663
GO:0032481
GO:0032494
GO:0032496
GO:0032675
GO:0032680
GO:0032722
GO:0032731
GO:0032740
GO:0032747
GO:0032755
GO:0032757
GO:0032760
GO:0034142
GO:0034146
GO:0034158
GO:0035325
GO:0035591
GO:0038124
GO:0038172
GO:0042127
GO:0042742
GO:0042802
GO:0043123
GO:0043226
GO:0043588
GO:0045944
GO:0046330
GO:0048856
GO:0050671
GO:0050727
GO:0050830
GO:0051607
GO:0060090
GO:0060337
GO:0060907
GO:0070498
GO:0070555
GO:0070935
GO:0070944
GO:0070976
GO:0071260
GO:0090557
GO:0098542
GO:0140052
GO:0140096
GO:0140097
GO:0140104
GO:0140657
GO:0140674
GO:1900017
GO:1900227
GO:1902622
GO:2000338
GO:2000341
Participates
as an input of
DHX36 or DHX9 binds MyD88 (Bos taurus)
as a component of
DHX9:CpG:MyD88 [cytosol] (Bos taurus)
DHX36:CpG:MyD88 [cytosol] (Bos taurus)
MYD88 dimer [cytosol] (Bos taurus)
Inferred From
MYD88 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSBTAP00000000735
,
ENSBTAT00000000735
VGNC
31789
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