Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CHUK [cytosol]
Stable Identifier
R-BTA-168104
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
Q95KV1
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to mechanical stimuli (Bos taurus)
Response of endothelial cells to shear stress (Bos taurus)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Bos taurus)
p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA) (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Downstream signaling events of B Cell Receptor (BCR) (Bos taurus)
Activation of NF-kappaB in B cells (Bos taurus)
Activated IKK phosphorylates I-kappaB (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
Activation of IKK complex (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Bos taurus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Interferon Signaling (Bos taurus)
Antiviral mechanism by IFN-stimulated genes (Bos taurus)
PKR-mediated signaling (Bos taurus)
IKK complex is activated by PKR (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Modulation of host responses by IFN-stimulated genes (Bos taurus)
FKBP5 binds CHUK:IKBKB:IKBKG (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
FKBP5:CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
FKBP5:CHUK [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 signaling (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
NEMO binds polyubiquitinated IRAK1 (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK, IKBKB and IKBKG form IKK complex (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
IKBIP binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
LRRC14 binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:LRRC14 [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
NLRC5 binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
NLRX1 binds CHUK:IKBKB:IKBKG (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
USP18 binds IKBKG within IKK complex (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Interleukin-17 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TNFR2 non-canonical NF-kB pathway (Bos taurus)
NIK-->noncanonical NF-kB signaling (Bos taurus)
Active NIK phosphorylates IKKA dimer (Bos taurus)
IKKA dimer [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
Dectin-1 mediated noncanonical NF-kB signaling (Bos taurus)
Active NIK phosphorylates IKKA dimer (Bos taurus)
IKKA dimer [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Bos taurus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated NF-kB activation (Bos taurus)
Phosphorylation of IKK-beta by TAK1 (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Bos taurus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
NEMO subunit of IKK complex binds to activated IRAK1 (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK, IKBKB and IKBKG form IKK complex (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
IKBIP binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
LRRC14 binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:LRRC14 [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
NLRC5 binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
NLRX1 binds CHUK:IKBKB:IKBKG (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
USP18 binds IKBKG within IKK complex (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
NEMO subunit of IKK complex binds to activated IRAK1 (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK, IKBKB and IKBKG form IKK complex (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
IKBIP binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
LRRC14 binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:LRRC14 [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
NLRC5 binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
NLRX1 binds CHUK:IKBKB:IKBKG (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
USP18 binds IKBKG within IKK complex (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
NEMO subunit of IKK complex binds to activated IRAK1 (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK, IKBKB and IKBKG form IKK complex (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
IKBIP binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
LRRC14 binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:LRRC14 [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
NLRC5 binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
NLRX1 binds CHUK:IKBKB:IKBKG (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
USP18 binds IKBKG within IKK complex (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK, IKBKB and IKBKG form IKK complex (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
IKBIP binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
LRRC14 binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:LRRC14 [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
NLRC5 binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
NLRX1 binds CHUK:IKBKB:IKBKG (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
USP18 binds IKBKG within IKK complex (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
IKK complex recruitment mediated by RIP1 (Bos taurus)
IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK, IKBKB and IKBKG form IKK complex (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
IKBIP binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
LRRC14 binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:LRRC14 [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
NLRC5 binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
NLRX1 binds CHUK:IKBKB:IKBKG (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
USP18 binds IKBKG within IKK complex (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
NEMO subunit of IKK complex binds to activated IRAK1 (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK, IKBKB and IKBKG form IKK complex (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
IKBIP binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
LRRC14 binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:LRRC14 [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
NLRC5 binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
NLRX1 binds CHUK:IKBKB:IKBKG (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
USP18 binds IKBKG within IKK complex (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
IRAK1 recruits IKK complex (Bos taurus)
NEMO subunit of IKK complex binds to activated IRAK1 (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK, IKBKB and IKBKG form IKK complex (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
IKBIP binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
LRRC14 binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:LRRC14 [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
NLRC5 binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
NLRX1 binds CHUK:IKBKB:IKBKG (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
USP18 binds IKBKG within IKK complex (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Bos taurus)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK, IKBKB and IKBKG form IKK complex (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
IKBIP binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
LRRC14 binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:LRRC14 [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
NLRC5 binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
NLRX1 binds CHUK:IKBKB:IKBKG (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
USP18 binds IKBKG within IKK complex (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
SLC15A4:TASL-dependent IRF5 activation (Bos taurus)
Activated IKBKB phosphorylates IRF5 (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Bos taurus)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK, IKBKB and IKBKG form IKK complex (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
IKBIP binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
LRRC14 binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:LRRC14 [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
NLRC5 binds IKBKB and CHUK (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
NLRX1 binds CHUK:IKBKB:IKBKG (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Bos taurus)
CHUK [cytosol] (Bos taurus)
USP18 binds IKBKG within IKK complex (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
SLC15A4:TASL-dependent IRF5 activation (Bos taurus)
Activated IKBKB phosphorylates IRF5 (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
TNF signaling (Bos taurus)
Regulation of TNFR1 signaling (Bos taurus)
GNB2L1 binds IKKA:IKKB:NEMO (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
IKKA:IKKB:NEMO:GNB2L1 [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TNFR1-induced NF-kappa-B signaling pathway (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q95KV1
Reference Genes
BioGPS Gene:281073
ENSEMBL:ENSBTAG00000007591
KEGG:bta:281073
Monarch:281073
NCBI Gene:281073
UCSC:Q95KV1
Reference Transcript
RefSeq:NM_174021.2
Participates
as a component of
FKBP5:CHUK [cytosol] (Bos taurus)
EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
IKKA dimer [cytosol] (Bos taurus)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Bos taurus)
CHUK:IKBKB:LRRC14 [cytosol] (Bos taurus)
CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] (Bos taurus)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Bos taurus)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Bos taurus)
CHUK:IKBKB:IKBKG [cytosol] (Bos taurus)
as an input of
LRRC14 binds IKBKB and CHUK (Bos taurus)
IKBIP binds IKBKB and CHUK (Bos taurus)
NLRC5 binds IKBKB and CHUK (Bos taurus)
CHUK, IKBKB and IKBKG form IKK complex (Bos taurus)
as an output of
TRAF2,6 ubiquitinates NLRC5 (Bos taurus)
Other forms of this molecule
phospho-p-Y187,Y198-CHUK [cytosol]
phospho-p-T23-CHUK [cytosol]
phospho-p-S176,S180-CHUK [cytosol]
Inferred From
CHUK [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_776446.1
IntEnz
2.7.11.10
VGNC
27354
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text