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NFKBIA [cytosol]
Stable Identifier
R-BTA-168151
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
NFKBIA, Q8WNW7
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to mechanical stimuli (Bos taurus)
Response of endothelial cells to shear stress (Bos taurus)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Bos taurus)
PTK2 (FAK) and Gq/11 enhance the degradation of NFKBIA (IkBalpha), phosphorylation of RELA (p65) on serine-536, and translocation of p-S536-RELA:NFKB1 (p65:p50) to the nucleus (Bos taurus)
IkB(alpha):NF-kB complex [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Downstream signaling events of B Cell Receptor (BCR) (Bos taurus)
Activation of NF-kappaB in B cells (Bos taurus)
Activated IKK phosphorylates I-kappaB (Bos taurus)
NF-kappa-B p50,p65,c-Rel:IKB [cytosol] (Bos taurus)
NF-KappaB p50:p50:IKBA [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NF-kappaB p50:c-Rel:IkB [cytosol] (Bos taurus)
IKB alpha,beta,epsilon [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NF-kappaB p50:p65:IKB [cytosol] (Bos taurus)
IKB alpha,beta,epsilon [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NF-kappaB p65:p65:IKB [cytosol] (Bos taurus)
IKB alpha,beta,epsilon [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Bos taurus)
IkB(alpha):NF-kB complex [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 signaling (Bos taurus)
IKBA is phosphorylated by Phospho IKKB kinase (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
NFkB inhibitor:NFkB complex [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NF-kappa-B inhibitor binds NF-kappa-B complex (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NFkB inhibitor:NFkB complex [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Bos taurus)
IkB(alpha):NF-kB complex [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
Cytosolic sensors of pathogen-associated DNA (Bos taurus)
ZBP1(DAI) mediated induction of type I IFNs (Bos taurus)
RIP-mediated NFkB activation via ZBP1 (Bos taurus)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Bos taurus)
NFkB inhibitor:NFkB complex [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Bos taurus)
TRAF6 mediated NF-kB activation (Bos taurus)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Bos taurus)
NFkB inhibitor:NFkB complex [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated NF-kB activation (Bos taurus)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Bos taurus)
IkB(alpha):NF-kB complex [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
NFkB inhibitor:NFkB complex [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NF-kappa-B inhibitor binds NF-kappa-B complex (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NFkB inhibitor:NFkB complex [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
NFkB inhibitor:NFkB complex [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NF-kappa-B inhibitor binds NF-kappa-B complex (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NFkB inhibitor:NFkB complex [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
NFkB inhibitor:NFkB complex [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NF-kappa-B inhibitor binds NF-kappa-B complex (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NFkB inhibitor:NFkB complex [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
NFkB inhibitor:NFkB complex [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NF-kappa-B inhibitor binds NF-kappa-B complex (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NFkB inhibitor:NFkB complex [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
NFkB inhibitor:NFkB complex [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NF-kappa-B inhibitor binds NF-kappa-B complex (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NFkB inhibitor:NFkB complex [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
NFkB inhibitor:NFkB complex [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NF-kappa-B inhibitor binds NF-kappa-B complex (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NFkB inhibitor:NFkB complex [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
NFkB inhibitor:NFkB complex [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NF-kappa-B inhibitor binds NF-kappa-B complex (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NFkB inhibitor:NFkB complex [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
NFkB inhibitor:NFkB complex [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NF-kappa-B inhibitor binds NF-kappa-B complex (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NFkB inhibitor:NFkB complex [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Bos taurus)
NFkB inhibitor:NFkB complex [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NF-kappa-B inhibitor binds NF-kappa-B complex (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
NFkB inhibitor:NFkB complex [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Deubiquitination (Bos taurus)
Ub-specific processing proteases (Bos taurus)
USP11 deubiquitinates NFKBIA (Bos taurus)
USP11:NFKBIA [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
p75 NTR receptor-mediated signalling (Bos taurus)
p75NTR signals via NF-kB (Bos taurus)
NF-kB is activated and signals survival (Bos taurus)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Bos taurus)
IkB(alpha):NF-kB complex [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q8WNW7
Gene Names
NFKBIA
Reference Genes
BioGPS Gene:282291 NFKBIA
ENSEMBL:ENSBTAG00000016683.6
KEGG:bta:282291 NFKBIA
Monarch:282291 NFKBIA
NCBI Gene:282291 NFKBIA
UCSC:Q8WNW7 NFKBIA
Reference Transcript
RefSeq:NM_001045868.1 NFKBIA
Other Identifiers
282291
GO:0002376
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006355
GO:0006606
GO:0006886
GO:0006913
GO:0007219
GO:0007249
GO:0008139
GO:0010468
GO:0010745
GO:0010875
GO:0010888
GO:0019899
GO:0031625
GO:0031663
GO:0032495
GO:0032496
GO:0033209
GO:0034142
GO:0035994
GO:0038061
GO:0042127
GO:0042802
GO:0043124
GO:0043226
GO:0043330
GO:0045638
GO:0045746
GO:0045893
GO:0045944
GO:0050729
GO:0050853
GO:0051059
GO:0051247
GO:0060261
GO:0070427
GO:0070431
GO:0070498
GO:0071356
GO:0098772
GO:0140311
GO:0140313
GO:0140416
Participates
as a component of
USP11:NFKBIA [cytosol] (Bos taurus)
NF-KappaB p50:p50:IKBA [cytosol] (Bos taurus)
IkB(alpha):NF-kB complex [cytosol] (Bos taurus)
as a member of
IKB alpha,beta,epsilon [cytosol] (Bos taurus)
NFkB inhibitor [cytosol] (Bos taurus)
as an input of
IKBA is phosphorylated by Phospho IKKB kinase (Bos taurus)
Other forms of this molecule
NFKBIA [cytosol]
NFKBIA [nucleoplasm]
NFKBIA [nucleoplasm]
phospho-NFKBIA [cytosol]
phospho-NFKBIA [cytosol]
Inferred From
NFKBIA [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001039333.1
ENSEMBL
ENSBTAT00000022183
,
ENSBTAP00000022183
VGNC
32045
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