Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
MAP3K14 [cytosol]
Stable Identifier
R-BTA-168189
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
MAP3K14, E1BL08
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Regulation of T cell activation by CD28 family (Bos taurus)
Co-stimulation by CD28 (Bos taurus)
CD28 dependent PI3K/Akt signaling (Bos taurus)
p-S400-Cot phosphorylates NIK (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
TNFR2 non-canonical NF-kB pathway (Bos taurus)
K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Bos taurus)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Bos taurus)
K48polyUb-TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
NIK-->noncanonical NF-kB signaling (Bos taurus)
Activation of NIK (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Active NIK phosphorylates IKKA dimer (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
NIK autophosphorylates on T559 (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
p100:RELB binds active NIK:p-IKKA dimer (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Protesomal degradation of K48polyUb-TRAF3 (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Bos taurus)
K48polyUb-TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Bos taurus)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Bos taurus)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Bos taurus)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
TRAF2:cIAP1/2 complex binds FN14:TWEAK (Bos taurus)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
TRAF3 binds BAFFR:BAFF (Bos taurus)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
TRAFs bind RANK:RANKL (Bos taurus)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Bos taurus)
Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Bos taurus)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
TRAF3:NIK binds TRAF2:cIAP1/2 (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Bos taurus)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Bos taurus)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
Dectin-1 mediated noncanonical NF-kB signaling (Bos taurus)
Activation of NIK (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Active NIK phosphorylates IKKA dimer (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
p100:RELB binds active NIK:p-IKKA dimer (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:E1BL08
Gene Names
MAP3K14
Reference Genes
ENSEMBL:ENSBTAG00000007084.6
UCSC:E1BL08 MAP3K14
Other Identifiers
508367
Bt.26906.1.S1_at
GO:0001650
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005654
GO:0005829
GO:0006468
GO:0006955
GO:0016740
GO:0038061
GO:0051607
GO:0071260
GO:0098542
GO:0140096
Participates
as an input of
NIK autophosphorylates on T559 (Bos taurus)
p-S400-Cot phosphorylates NIK (Bos taurus)
Active NIK phosphorylates IKKA dimer (Bos taurus)
Activation of NIK (Bos taurus)
as an output of
Activation of NIK (Bos taurus)
Protesomal degradation of K48polyUb-TRAF3 (Bos taurus)
as a component of
TRAF3:NIK [cytosol] (Bos taurus)
K48polyUb-TRAF3:NIK [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
Other forms of this molecule
phospho-MAP3K14 [cytosol]
MAP3K14 [cytosol]
phospho-MAP3K14 [cytosol]
Inferred From
MAP3K14 [cytosol]
(Homo sapiens)
Active NIK [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSBTAP00000009316
,
ENSBTAG00000007084
,
ENSBTAT00000009316
VGNC
31192
© 2025
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text