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phospho-p-S222,S226-MAP2K2 [cytosol]
Stable Identifier
R-BTA-169292
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
A0A3S5ZPX3
Locations in the PathwayBrowser
Expand all
Signal Transduction (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
MAP2K and MAPK activation (Bos taurus)
Dissociation of RAS:RAF complex (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
Dual mechanism MAPK inhibitors bind MAPKs (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
IL17RD binds p-2S MAP2Ks and MAPKs (Bos taurus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Bos taurus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Bos taurus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
MAP2Ks phosphorylate MAPKs (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
RAF phosphorylates MAP2K dimer (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
Negative regulation of MAPK pathway (Bos taurus)
Negative feedback regulation of MAPK pathway (Bos taurus)
Activated MAPKs phosphorylate MAP2K1 (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-2S,T MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
RAF activation (Bos taurus)
Phosphorylation of RAF (Bos taurus)
RAF activating kinases [plasma membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
Signalling to ERKs (Bos taurus)
Prolonged ERK activation events (Bos taurus)
Frs2-mediated activation (Bos taurus)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Bos taurus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
Dissociation of phosphorylated MAP2Ks and MAPKs (Bos taurus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Bos taurus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Bos taurus)
p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:A0A3S5ZPX3
Reference Genes
ENSEMBL:ENSBTAG00000024450.5
Other Identifiers
510434
GO:0000165
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0004708
GO:0005524
GO:0006468
GO:0016740
GO:0023052
GO:0036211
GO:0140096
Participates
as a component of
p-2S,T MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
p-S222,S226 MAP2K2 dimer [cytosol] (Bos taurus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Bos taurus)
Other forms of this molecule
phospho-p-S,T-MAP2K2 [cytosol]
MAP2K2 [cytosol]
Inferred From
p-S222,S226-MAP2K2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 222 (in Homo sapiens)
Coordinate
222
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 226 (in Homo sapiens)
Coordinate
226
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
Ensembl
ENSBTAG00000024450
,
ENSBTAT00000011377
,
ENSBTAP00000011377
VGNC
55215
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