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SKP1 [cytosol]
Stable Identifier
R-BTA-174150
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
SKP1, Q3ZCF3
Locations in the PathwayBrowser
Expand all
Cell Cycle (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
Mitotic G2-G2/M phases (Bos taurus)
G2/M Transition (Bos taurus)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Bos taurus)
Formation of the SCF-FBXL7 complex (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Bos taurus)
SCF-FBXL7:PolyUb-AURKA [cytosol] (Bos taurus)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-FBXL18 ubiquitinates FBXL7 (Bos taurus)
SKP1:CUL1:RBX1:FBXL18 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-FBXL7 ubiquitinates AURKA (Bos taurus)
SCF-FBXL7:AURKA [cytosol] (Bos taurus)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-FBXL7:PolyUb-AURKA [cytosol] (Bos taurus)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF:FBXL7 binds AURKA (Bos taurus)
SCF-FBXL7:AURKA [cytosol] (Bos taurus)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Regulation of PLK1 Activity at G2/M Transition (Bos taurus)
Phosphorylated BORA binds SCF-beta-TrCp1/2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
p-S252,S497,T501-BORA:SCF-beta-TrCp1/2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
p-S252,S497,T501-BORA:SCF-beta-TrCp1/2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Regulation of mitotic cell cycle (Bos taurus)
APC/C-mediated degradation of cell cycle proteins (Bos taurus)
Regulation of APC/C activators between G1/S and early anaphase (Bos taurus)
SCF-beta-TrCP mediated degradation of Emi1 (Bos taurus)
Ubiquitination of Emi1 by SCF-beta-TrCP (Bos taurus)
SCF-associated multiubiquitinated Emi1complexes [cytosol] (Bos taurus)
SCF-beta-TrCP:phospho-Emi1 complexes [cytosol] (Bos taurus)
BTRC:CUL1:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP:phospho-Emi1 complexes [cytosol] (Bos taurus)
BTRC:CUL1:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Polyubiquitination of substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Release of E3 from polyubiquitinated substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Downstream signaling events of B Cell Receptor (BCR) (Bos taurus)
Activation of NF-kappaB in B cells (Bos taurus)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP ubiquitinylates IkB (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 signaling (Bos taurus)
Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Bos taurus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
BTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Bos taurus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 [cytosol] (Bos taurus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Bos taurus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 [cytosol] (Bos taurus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Interleukin-17 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
TNFR2 non-canonical NF-kB pathway (Bos taurus)
NIK-->noncanonical NF-kB signaling (Bos taurus)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Bos taurus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Bos taurus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
Dectin-1 mediated noncanonical NF-kB signaling (Bos taurus)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Bos taurus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Bos taurus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated NF-kB activation (Bos taurus)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
MAP kinase activation (Bos taurus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Bos taurus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Neddylation (Bos taurus)
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Bos taurus)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Bos taurus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
NEDD8-CRL1 E3 ligase complex [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Bos taurus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
NEDD8-CRL1 E3 ligase complex [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Bos taurus)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Bos taurus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Bos taurus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Hedgehog (Bos taurus)
Hedgehog 'off' state (Bos taurus)
Degradation of GLI1 by the proteasome (Bos taurus)
SCF(beta-TrCP) ubiquitinates p-GLI1 (Bos taurus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
GLI3 is processed to GLI3R by the proteasome (Bos taurus)
SCF(beta-TrCP) ubiquitinates p-GLI3 (Bos taurus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Signaling by WNT (Bos taurus)
Degradation of beta-catenin by the destruction complex (Bos taurus)
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Bos taurus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Bos taurus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Degradation of ubiquitinated beta catenin by the proteasome (Bos taurus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Bos taurus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Bos taurus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Bos taurus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Bos taurus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Bos taurus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Bos taurus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
Transport of small molecules (Bos taurus)
Iron uptake and transport (Bos taurus)
CUL1, SKP1, FBXL5 bind (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SKP1:CUL1:FBXL5 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Bos taurus)
SKP1:CUL1:FBXL5 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SKP1:FBXL5:CUL1:NEDD8 [cytosol] (Bos taurus)
SKP1:CUL1:FBXL5 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Bos taurus)
SKP1:FBXL5:CUL1:NEDD8 [cytosol] (Bos taurus)
SKP1:CUL1:FBXL5 [cytosol] (Bos taurus)
SKP1 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q3ZCF3
Gene Names
SKP1
Reference Genes
BioGPS Gene:615427 SKP1
ENSEMBL:ENSBTAG00000025191
ENSEMBL:ENSBTAG00000025191.6 SKP1
KEGG Gene (Bos taurus):615427 SKP1
Monarch:615427 SKP1
NCBI Gene:615427 SKP1
Reference Transcript
RefSeq:NM_001034781.2 SKP1
Other Identifiers
615427
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006513
GO:0019005
GO:0030163
GO:0031146
GO:0031467
GO:0036211
GO:0043226
GO:0070936
Participates
as a component of
NEDD8-CRL1 E3 ligase complex [cytosol] (Bos taurus)
SKP1:CUL1:FBXL5 [cytosol] (Bos taurus)
SKP1:CUL1:RBX1:FBXL18 [cytosol] (Bos taurus)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Bos taurus)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Bos taurus)
SCF E3 ubiquitin ligase [cytosol] (Bos taurus)
RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Bos taurus)
CUL1:FBXW11:SKP1 [cytosol] (Bos taurus)
BTRC:CUL1:SKP1 [cytosol] (Bos taurus)
as an input of
CUL1, SKP1, FBXL5 bind (Bos taurus)
Formation of the SCF-FBXL7 complex (Bos taurus)
Other forms of this molecule
SKP1 [nucleoplasm]
Inferred From
SKP1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001029953.1
OpenTargets
ENSG00000113558
Ensembl
ENSBTAT00000035306
,
ENSBTAP00000035184
,
ENSBTAG00000025191
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