Reactome | EPS15 [cytosol]

EPS15 [cytosol]

Stable Identifier

R-BTA-182920

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

EPS15, A5D7I1

Locations in the PathwayBrowser

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Vesicle-mediated transport (Bos taurus)

- Membrane Trafficking (Bos taurus)
  - Clathrin-mediated endocytosis (Bos taurus)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Bos taurus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
    - BAR domain proteins recruit dynamin (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Bos taurus)
      - CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
    - Cargo recognition for clathrin-mediated endocytosis (Bos taurus)
      - ARBB recruits GPCRs into clathrin-coated pits (Bos taurus)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        UBQLN2:UIM-containing proteins [cytosol] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
      - Epsin family proteins bind ubiquitinated cargo (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
      - UBQLNs bind UIM-containing adaptor proteins (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        UNQLNs:UIM proteins [cytosol] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
    - Clathrin recruits PIK3C2A (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
    - RAB5 and GAPVD1 bind AP-2 (Bos taurus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
    - Recruitment of AP-2 complex and clathrin (Bos taurus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
    - SNX9 recruits components of the actin polymerizing machinery (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
        
        EPS15,EPN1,EPN2 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)
        
        EPS15 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:A5D7I1

Gene Names

EPS15

Reference Genes

BioGPS Gene:535998 EPS15

ENSEMBL:ENSBTAG00000005542.6

KEGG Gene (Bos taurus):535998 EPS15

Monarch:535998 EPS15

NCBI Gene:535998 EPS15

Reference Transcript

RefSeq:NM_001098087.1 EPS15

Other Identifiers

535998

GO:0005509

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0006895

GO:0006897

GO:0016192

GO:0016197

GO:0016235

GO:0019065

GO:0030132

GO:0031593

GO:0043226

GO:0043231

GO:0046718

GO:0046872

GO:0048268

GO:0065003

Participates

as a component of

as a member of

EPS15,EPN1,EPN2 [cytosol] (Bos taurus)

Other forms of this molecule

phospho-EPS15 [cytosol]

Inferred From

EPS15 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001091556.1

OpenTargets

ENSG00000085832

Ensembl

ENSBTAG00000005542, ENSBTAT00000053382, ENSBTAP00000052345

VGNC

28553

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