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SQSTM1 [cytosol]
Stable Identifier
R-BTA-193937
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
SQSTM1, A0A3Q1LVE4
Locations in the PathwayBrowser
Expand all
Autophagy (Bos taurus)
Macroautophagy (Bos taurus)
Selective autophagy (Bos taurus)
Mitophagy (Bos taurus)
PINK1-PRKN Mediated Mitophagy (Bos taurus)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Bos taurus)
ATG5:ATG12:LC3:K48polyUB Mitophagy Substrates:SQSTM1 [phagocytic vesicle] (Bos taurus)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Bos taurus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Bos taurus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
p62 binds ubiquitinated mitochondrial substrates (Bos taurus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
p62 links damaged mitochondria to LC3 (Bos taurus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Bos taurus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
Pexophagy (Bos taurus)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Bos taurus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
ATM dimer:Ub-p-PEX5:SQSTM1:MAP1LC3B [peroxisomal membrane] (Bos taurus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Bos taurus)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Bos taurus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1:MAP1LC3B [peroxisomal membrane] (Bos taurus)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Bos taurus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Bos taurus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Bos taurus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Bos taurus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
KEAP1-NFE2L2 pathway (Bos taurus)
SQSTM1 oligomerizes (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
SQSTM1 oligomer [cytosol] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
TRIM21 ubiquitinates SQSTM1 (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 signaling (Bos taurus)
p62:MEKK3 binds to TRAF6 (Bos taurus)
MAP3K3:SQSTM1 [cytosol] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Bos taurus)
MAP3K3:SQSTM1 [cytosol] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
p75 NTR receptor-mediated signalling (Bos taurus)
Cell death signalling via NRAGE, NRIF and NADE (Bos taurus)
NRIF signals cell death from the nucleus (Bos taurus)
Polyubiquitinated NRIF binds to p62 (Sequestosome) (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
Ubiquitinated NRIF:Sequestosome [cytosol] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
Polyubiquitinated NRIF migrates to the nucleus (Bos taurus)
Ubiquitinated NRIF:Sequestosome [cytosol] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
p75NTR signals via NF-kB (Bos taurus)
NF-kB is activated and signals survival (Bos taurus)
IKKbeta is activated (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
p75NTR recruits signalling complexes (Bos taurus)
IKK-beta is recruited (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
TRAF6 is auto-ubiquitinated (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
p62 is recruited and forms a complex with TRAF6 (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
p62 recruits an atypical PKC (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Bos taurus)
SQSTM1 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:A0A3Q1LVE4
Gene Names
SQSTM1
Reference Genes
ENSEMBL:ENSBTAG00000015591.6
UCSC:A0A3Q1LVE4 SQSTM1
Other Identifiers
338045
GO:0000122
GO:0000407
GO:0000423
GO:0000425
GO:0000932
GO:0001659
GO:0005080
GO:0005737
GO:0005739
GO:0005764
GO:0005773
GO:0005776
GO:0005829
GO:0006351
GO:0006355
GO:0006366
GO:0006606
GO:0006886
GO:0006913
GO:0006914
GO:0007005
GO:0007032
GO:0010508
GO:0016234
GO:0016235
GO:0016236
GO:0016605
GO:0019899
GO:0019901
GO:0030163
GO:0030674
GO:0031397
GO:0031625
GO:0034144
GO:0035255
GO:0035591
GO:0035973
GO:0038023
GO:0042169
GO:0042802
GO:0043122
GO:0043130
GO:0043226
GO:0043231
GO:0043232
GO:0044753
GO:0044754
GO:0060089
GO:0060090
GO:0061635
GO:0070342
GO:0070530
GO:0071211
GO:0097009
GO:0097225
GO:0098780
GO:0110076
GO:0140036
GO:0140311
GO:0140313
GO:0140693
GO:0140694
GO:1900273
GO:1903078
GO:1905719
Participates
as an input of
TRIM21 ubiquitinates SQSTM1 (Bos taurus)
SQSTM1 oligomerizes (Bos taurus)
Polyubiquitinated NRIF binds to p62 (Sequestosome) (Bos taurus)
p62 is recruited and forms a complex with TRAF6 (Bos taurus)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Bos taurus)
p62 binds ubiquitinated mitochondrial substrates (Bos taurus)
as a component of
SQSTM1 oligomer [cytosol] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Bos taurus)
Ubiquitinated NRIF:Sequestosome [cytosol] (Bos taurus)
MAP3K3:SQSTM1 [cytosol] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Bos taurus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Bos taurus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Bos taurus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Bos taurus)
Other forms of this molecule
SQSTM1 [cytosol]
phospho-SQSTM1 [cytosol]
phospho-SQSTM1 [cytosol]
SQSTM1 [nucleoplasm]
Inferred From
SQSTM1 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSBTAP00000059264
,
ENSBTAG00000015591
,
ENSBTAT00000075019
VGNC
35265
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