Reactome | IkB(alpha):NF-kB complex [cytosol]

IkB(alpha):NF-kB complex [cytosol]

Stable Identifier

R-BTA-193938

Type

Complex

Species

Bos taurus

Compartment

cytosol

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

NFKB1(1-433):RELA [cytosol] (Bos taurus)
NFKBIA [cytosol] (Bos taurus)

Participates

as an input of

PTK2 (FAK) and Gq/11 enhance the degradation of NFKBIA (IkBalpha), phosphorylation of RELA (p65) on serine-536, and translocation of p-S536-RELA:NFKB1 (p65:p50) to the nucleus (Bos taurus)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Bos taurus)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Bos taurus)

Inferred From

IkB(alpha):NF-kB complex [cytosol] (Homo sapiens)

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