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PIK3R1 [plasma membrane]
Stable Identifier
R-BTA-198365
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
plasma membrane
Synonyms
PIK3R1, P23727
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
BCAP Signalosome [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
CD19 Signalosome [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
p-CD19:VAV binds PI3K and GRB2 (Bos taurus)
CD19 Signalosome [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
BCAP Signalosome [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
CD19 Signalosome [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
BCAP Signalosome [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
CD19 Signalosome [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ERBB2 (Bos taurus)
PI3K events in ERBB2 signaling (Bos taurus)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Bos taurus)
PIK3R1 [plasma membrane] (Bos taurus)
External Reference Information
External Reference
UniProt:P23727
Gene Names
PIK3R1
Reference Genes
BioGPS Gene:282307 PIK3R1
ENSEMBL:ENSBTAG00000010989
KEGG:bta:282307 PIK3R1
Monarch:282307 PIK3R1
NCBI Gene:282307 PIK3R1
UCSC:P23727 PIK3R1
Reference Transcript
RefSeq:XM_005221436.3 PIK3R1
RefSeq:NM_174575.1 PIK3R1
Participates
as a component of
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Bos taurus)
PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Bos taurus)
Other forms of this molecule
PIK3R1 [cytosol]
PIK3R1 [cytosol]
Inferred From
PIK3R1 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
NP_777000.1
,
XP_005221493.1
VGNC
32894
PDB
6OCU
,
6G6W
,
1OO3
,
2PNA
,
2PNB
,
6OCO
,
1BFI
,
1BFJ
,
8BCY
,
6D85
,
6D86
,
7JIS
,
6R4R
,
5T8F
,
1PNJ
,
2PNI
,
6D81
,
6D87
,
6MRP
,
5DXU
,
5DXH
,
6D82
,
1QAD
,
1OO4
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P09619 PDGFRB
3
p-12Y-PDGFRB [plasma membrane]
(R-HSA-186803)
PDGFRB [plasma membrane]
(R-HSA-186767)
p-11Y-PDGFRB [plasma membrane]
(R-HSA-8864039)
0.725
6
UniProt:P23727
3
PIK3R1 [cytosol]
(R-BTA-3080572)
PIK3R1 [cytosol]
(R-BTA-74789)
PIK3R1 [plasma membrane]
(R-BTA-198365)
0.624
4
UniProt:P20339 RAB5A
7
RAB5A [cytosol]
(R-HSA-2201187)
GGC-RAB5A [macropinosome membrane]
(R-HSA-9837697)
RAB5A [endosome membrane]
(R-HSA-452257)
RAB5A [early endosome membrane]
(R-HSA-2130175)
GGC-RAB5A [cytosol]
(R-HSA-8870432)
GGC-RAB5A [early endosome membrane]
(R-HSA-8875323)
GGC-RAB5A [clathrin-coated endocytic vesicle membrane]
(R-HSA-8871125)
0.558
5
UniProt:P32871
1
PIK3CA [cytosol]
(R-BTA-74787)
0.524
4
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