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PTN [extracellular region]
Stable Identifier
R-BTA-201500
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
extracellular region
Synonyms
PTN, P21782
Locations in the PathwayBrowser
Expand all
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ALK (Bos taurus)
ALK autophosphorylation (Bos taurus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Bos taurus)
ligand-bound ALK dimer [plasma membrane] (Bos taurus)
PTN:ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
ligand-bound ALK dimer [plasma membrane] (Bos taurus)
PTN:ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
Active ALK binds JAK3 (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
Active ALK:JAK3 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
Active ALK binds PLCG1 (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
Active ALK:PLCG1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
Active ALK binds SHC1 (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
Active ALK:SHC1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
Active ALK dimer binds IRS1 (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
Active ALK:IRS1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
Active ALK phosphorylates IRS1 (Bos taurus)
Active ALK:IRS1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
Active ALK:pY-IRS1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
Active ALK phosphorylates JAK3 (Bos taurus)
Active ALK:JAK3 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
Active ALK:p-Y980 JAK3 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
Active ALK phosphorylates PLCG1 (Bos taurus)
Active ALK:PLCG1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
Active ALK:p-4Y PLCG1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
Active ALK phosphorylates SHC1 (Bos taurus)
Active ALK:SHC1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
Active ALK:p-3Y SHC1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
Active ALK recruits PI3K (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
Active ALK:PI3K [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
Liganded-ALK dimer binds type I ALK-binding TKIs (Bos taurus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Bos taurus)
ligand-bound ALK dimer [plasma membrane] (Bos taurus)
PTN:ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
ligand-bound ALK dimer [plasma membrane] (Bos taurus)
PTN:ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
MDK and PTN in ALK signaling (Bos taurus)
(PTN,MDK):PTPRZ oligomerizes (Bos taurus)
(PTN,MDK):PTPRZ [plasma membrane] (Bos taurus)
PTN,MDK [extracellular region] (Bos taurus)
PTN [extracellular region] (Bos taurus)
(PTN,MDK):PTPRZ oligomers [plasma membrane] (Bos taurus)
(PTN,MDK):PTPRZ [plasma membrane] (Bos taurus)
PTN,MDK [extracellular region] (Bos taurus)
PTN [extracellular region] (Bos taurus)
ALK binds ligand pleiotrophin (PTN) (Bos taurus)
PTN [extracellular region] (Bos taurus)
PTN:ALK [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
PTN and MDK bind to PTPRZ (Bos taurus)
(PTN,MDK):PTPRZ [plasma membrane] (Bos taurus)
PTN,MDK [extracellular region] (Bos taurus)
PTN [extracellular region] (Bos taurus)
PTN,MDK [extracellular region] (Bos taurus)
PTN [extracellular region] (Bos taurus)
PTPRZ dephosphorylates ligand-bound ALK dimers (Bos taurus)
(PTN,MDK):ALK dimer [plasma membrane] (Bos taurus)
PTN:ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
(PTN,MDK):PTPRZ oligomers [plasma membrane] (Bos taurus)
(PTN,MDK):PTPRZ [plasma membrane] (Bos taurus)
PTN,MDK [extracellular region] (Bos taurus)
PTN [extracellular region] (Bos taurus)
(PTN,MDK):p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
PI3K synthesizes PIP3 downstream of ALK (Bos taurus)
Active ALK:PI3K [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
PTPN6 dephosphorylates JAK3 (Bos taurus)
Active ALK:JAK3 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
Active ALK:p-Y980 JAK3 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
STAT3 is phosphorylated downstream of active ALK (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN [extracellular region] (Bos taurus)
External Reference Information
External Reference
UniProt:P21782
Gene Names
PTN
Reference Genes
BioGPS Gene:280904 PTN
ENSEMBL:ENSBTAG00000002317
Monarch:280904 PTN
NCBI Gene:280904 PTN
UCSC:P21782 PTN
Reference Transcript
RefSeq:XM_005205790.3 PTN
RefSeq:NM_173955.1 PTN
Participates
as a member of
PTN,MDK [extracellular region] (Bos taurus)
as a component of
PTN:p-7Y ALK dimer [plasma membrane] (Bos taurus)
PTN:ALK [plasma membrane] (Bos taurus)
PTN:ALK dimer [plasma membrane] (Bos taurus)
as an input of
ALK binds ligand pleiotrophin (PTN) (Bos taurus)
Inferred From
PTN [extracellular region]
(Homo sapiens)
Cross References
VGNC
33521
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