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PTK2 [cytosol]
Stable Identifier
R-BTA-201621
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
A0A3Q1N508
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to mechanical stimuli (Bos taurus)
Response of endothelial cells to shear stress (Bos taurus)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Bos taurus)
Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow (Bos taurus)
PTK2 [cytosol] (Bos taurus)
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
Platelet Aggregation (Plug Formation) (Bos taurus)
Integrin signaling (Bos taurus)
Autophosphorylation of PTK2 at Y397 (Bos taurus)
PTK2 [cytosol] (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
PTK2 [cytosol] (Bos taurus)
Translocation of PTK2 to Focal complexes (Bos taurus)
PTK2 [cytosol] (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
PTK2 [cytosol] (Bos taurus)
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
Src phosphorylate WASP,N-WASP (Bos taurus)
Src-kinases [cytosol] (Bos taurus)
PTK2 [cytosol] (Bos taurus)
Programmed Cell Death (Bos taurus)
Apoptosis (Bos taurus)
Apoptotic execution phase (Bos taurus)
Apoptotic cleavage of cellular proteins (Bos taurus)
Caspase-mediated cleavage of FADK 1 (Bos taurus)
PTK2 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Integrin signaling (Bos taurus)
Autophosphorylation of PTK2 at Y397 (Bos taurus)
PTK2 [cytosol] (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
PTK2 [cytosol] (Bos taurus)
Translocation of PTK2 to Focal complexes (Bos taurus)
PTK2 [cytosol] (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
PTK2 [cytosol] (Bos taurus)
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Extra-nuclear estrogen signaling (Bos taurus)
PTK2 autophosphorylates downstream of EGFR (Bos taurus)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Bos taurus)
PTK2 [cytosol] (Bos taurus)
PTK2 [cytosol] (Bos taurus)
PTK2 binds activated EGFR (Bos taurus)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Bos taurus)
PTK2 [cytosol] (Bos taurus)
PTK2 [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by MET (Bos taurus)
MET promotes cell motility (Bos taurus)
MET activates PTK2 signaling (Bos taurus)
PTK2 autophosphorylates (Bos taurus)
HGF:p-4Y-MET dimer:PTK2 [plasma membrane] (Bos taurus)
PTK2 [cytosol] (Bos taurus)
PTK2 [cytosol] (Bos taurus)
PTK2 binds activated MET (Bos taurus)
HGF:p-4Y-MET dimer:PTK2 [plasma membrane] (Bos taurus)
PTK2 [cytosol] (Bos taurus)
PTK2 [cytosol] (Bos taurus)
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
PTK2 autophosphorylates (Bos taurus)
PTK2 [cytosol] (Bos taurus)
VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane] (Bos taurus)
PTK2 [cytosol] (Bos taurus)
PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Bos taurus)
PTK2 [cytosol] (Bos taurus)
VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane] (Bos taurus)
PTK2 [cytosol] (Bos taurus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases Activate WASPs and WAVEs (Bos taurus)
Src phosphorylate WASP,N-WASP (Bos taurus)
Src-kinases [cytosol] (Bos taurus)
PTK2 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:A0A3Q1N508
Reference Genes
ENSEMBL:ENSBTAG00000009578.6
UCSC:A0A3Q1N508
Other Identifiers
GO:0003824
GO:0004713
GO:0004715
GO:0005524
GO:0005737
GO:0005856
GO:0005886
GO:0005925
GO:0005938
GO:0007172
GO:0008284
GO:0016301
GO:0016740
GO:0030054
GO:0042995
GO:0043226
GO:0051128
GO:0051239
GO:0065003
GO:0065008
GO:0070161
GO:0140096
Participates
as an input of
Translocation of PTK2 to Focal complexes (Bos taurus)
Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow (Bos taurus)
PTK2 binds activated MET (Bos taurus)
PTK2 binds activated EGFR (Bos taurus)
PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Bos taurus)
Caspase-mediated cleavage of FADK 1 (Bos taurus)
as a component of
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
HGF:p-4Y-MET dimer:PTK2 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Bos taurus)
VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane] (Bos taurus)
as a member of
Src-kinases [cytosol] (Bos taurus)
Other forms of this molecule
phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
phospho-p-Y194,Y397-PTK2 [cytosol]
phospho-pY-PTK2 [cytosol]
phospho-p-5Y-PTK2 [cytosol]
phospho-p-5Y,S732-PTK2 [cytosol]
phospho-p-6Y,S732-PTK2 [cytosol]
PTK2(773-1052) [cytosol]
PTK2(1-772) [cytosol]
phospho-p-Y397-PTK2 [cytosol]
phospho-p-6Y-PTK2 [cytosol]
Inferred From
PTK2 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSBTAT00000085237
,
ENSBTAP00000065036
VGNC
33518
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