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CRK [cytosol]
Stable Identifier
R-BTA-2980677
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
CRK, E1BQ32
Locations in the PathwayBrowser
Expand all
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
Platelet Aggregation (Plug Formation) (Bos taurus)
Integrin signaling (Bos taurus)
p130Cas linkage to MAPK signaling for integrins (Bos taurus)
Crk binding to p130cas (Bos taurus)
CRK [cytosol] (Bos taurus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
CRK [cytosol] (Bos taurus)
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
Regulation of signaling by CBL (Bos taurus)
CBL binds CRK (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
p(Y700,731,774)-CBL:CRK [cytosol] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
CBL:CRKL binds RAPGEF1 (Bos taurus)
p(Y700,731,774)-CBL:CRK [cytosol] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
p(Y700,731,774)-CBL:CRK:RAPGEF1 [cytosol] (Bos taurus)
p(Y700,731,774)-CBL:CRK [cytosol] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
Activation of RAC1 by CRKII:DOCK180:ELMO (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Integrin signaling (Bos taurus)
p130Cas linkage to MAPK signaling for integrins (Bos taurus)
Crk binding to p130cas (Bos taurus)
CRK [cytosol] (Bos taurus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
CRK [cytosol] (Bos taurus)
Signaling by Non-Receptor Tyrosine Kinases (Bos taurus)
Signaling by PTK6 (Bos taurus)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Bos taurus)
Activation of RAC1 by the PXN:CRK complex (Bos taurus)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
Phosphorylated PXN recruits the CRK complex (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by MET (Bos taurus)
MET promotes cell motility (Bos taurus)
MET activates RAP1 and RAC1 (Bos taurus)
CRK,CRKL recruits RAC1 GEF to activated MET (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
DOCK7 activates RAC1 (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
GAB1 recruits CRK,CRKL to MET (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
RAPGEF1 activates RAP1 (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
RAPGEF1 binds CRK,CRKL (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
MET receptor recycling (Bos taurus)
GGA3 associates with activated MET receptor (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
Signalling to ERKs (Bos taurus)
Prolonged ERK activation events (Bos taurus)
ARMS-mediated activation (Bos taurus)
ARMS is phosphorylated by active TrkA receptor (Bos taurus)
Active TrkA receptor:ARMS:Crk complex [plasma membrane] (Bos taurus)
ARMS:Crk [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Bos taurus)
Phospho-ARMS:Crk [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
C3G stimulates nucleotide exchange on Rap1 (Bos taurus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Bos taurus)
Phospho-ARMS:Crk [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
Crk's SH3 domain engages C3G (Bos taurus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Bos taurus)
Phospho-ARMS:Crk [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
Signaling by PDGF (Bos taurus)
Downstream signal transduction (Bos taurus)
Crk binds to the active PDGF receptor (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
p130Cas and C3G bind PDGFR bound Crk (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
CRK binds BCAR1 and or PXN (Bos taurus)
CRK [cytosol] (Bos taurus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Bos taurus)
CRK [cytosol] (Bos taurus)
DOCK180:ELMO binds CRK (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Bos taurus)
CRK [cytosol] (Bos taurus)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
CRK [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:E1BQ32
Gene Names
CRK
Reference Genes
ENSEMBL:ENSBTAG00000005665.6
KEGG:bta:512841 CRK
UCSC:E1BQ32 CRK
Other Identifiers
512841
GO:0001764
GO:0001784
GO:0002376
GO:0002685
GO:0005856
GO:0006629
GO:0007010
GO:0007163
GO:0007167
GO:0008283
GO:0008360
GO:0009966
GO:0015629
GO:0016020
GO:0016358
GO:0017124
GO:0019900
GO:0021766
GO:0021987
GO:0030010
GO:0030036
GO:0030159
GO:0031594
GO:0031625
GO:0032956
GO:0032991
GO:0033628
GO:0035022
GO:0035591
GO:0035685
GO:0038026
GO:0042169
GO:0043226
GO:0045309
GO:0046875
GO:0048013
GO:0048856
GO:0048870
GO:0050773
GO:0060090
GO:0060326
GO:0061045
GO:0098698
GO:0098749
GO:1900026
GO:1902531
GO:1904395
GO:1990782
GO:2000146
GO:2000404
Participates
as an input of
Crk binding to p130cas (Bos taurus)
CRK binds BCAR1 and or PXN (Bos taurus)
as a component of
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
ARMS:Crk [cytosol] (Bos taurus)
Phospho-ARMS:Crk [cytosol] (Bos taurus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
as a member of
CRK, CRKL [cytosol] (Bos taurus)
Inferred From
CRK [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSBTAP00000007443
,
ENSBTAT00000007443
VGNC
27716
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