Reactome | PIK3R1 [cytosol]

PIK3R1 [cytosol]

Stable Identifier

R-BTA-3080572

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

K63polyUb-PIK3R1, P23727

Locations in the PathwayBrowser

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Immune System (Bos taurus)

- Cytokine Signaling in Immune system (Bos taurus)
  - Signaling by Interleukins (Bos taurus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
      - Regulation of signaling by CBL (Bos taurus)
        
        CBL ubiquitinates PI3K (Bos taurus)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        K63polyUb-PI3K alpha [cytosol] (Bos taurus)
        
        K63polyUb-PI3K-regulatory subunits [cytosol] (Bos taurus)
        
        PIK3R1 [cytosol] (Bos taurus)
        
        K63polyUb-PI3K beta [cytosol] (Bos taurus)
        
        K63polyUb-PI3K-regulatory subunits [cytosol] (Bos taurus)
        
        PIK3R1 [cytosol] (Bos taurus)
        
        K63polyUb-PI3K delta [cytosol] (Bos taurus)
        
        K63polyUb-PI3K-regulatory subunits [cytosol] (Bos taurus)
        
        PIK3R1 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:P23727

Gene Names

PIK3R1

Reference Genes

BioGPS Gene:282307 PIK3R1

ENSEMBL:ENSBTAG00000010989

KEGG:bta:282307 PIK3R1

Monarch:282307 PIK3R1

NCBI Gene:282307 PIK3R1

UCSC:P23727 PIK3R1

Reference Transcript

Participates

as a member of

K63polyUb-PI3K-regulatory subunits [cytosol] (Bos taurus)

Other forms of this molecule

PIK3R1 [cytosol]

PIK3R1 [plasma membrane]

Inferred From

K63polyUb-PIK3R1 [cytosol] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at unknown position

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

XP_005221493.1, NP_777000.1

VGNC

32894

PDB

2PNB, 7JIS, 5DXH, 2PNA, 1PNJ, 1OO3, 1OO4, 1BFI, 1BFJ, 1QAD, 5DXU, 6G6W, 6R4R, 6D82, 8BCY, 6OCU, 6D85, 2PNI, 6OCO, 6D81, 5T8F, 8S3R, 6D86, 6MRP, 6D87

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09619 PDGFRB	3	p-12Y-PDGFRB [plasma membrane] (R-HSA-186803) PDGFRB [plasma membrane] (R-HSA-186767) p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039)	0.725	6
UniProt:P23727	3	PIK3R1 [cytosol] (R-BTA-3080572) PIK3R1 [cytosol] (R-BTA-74789) PIK3R1 [plasma membrane] (R-BTA-198365)	0.624	4
UniProt:P20339 RAB5A	7	RAB5A [cytosol] (R-HSA-2201187) GGC-RAB5A [macropinosome membrane] (R-HSA-9837697) RAB5A [endosome membrane] (R-HSA-452257) RAB5A [early endosome membrane] (R-HSA-2130175) GGC-RAB5A [cytosol] (R-HSA-8870432) GGC-RAB5A [early endosome membrane] (R-HSA-8875323) GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125)	0.558	5
UniProt:P32871	1	PIK3CA [cytosol] (R-BTA-74787)	0.524	4

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