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VCL [cytosol]
Stable Identifier
R-BTA-350753
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
VCL, F1N789
Locations in the PathwayBrowser
Expand all
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
Response to elevated platelet cytosolic Ca2+ (Bos taurus)
Platelet degranulation (Bos taurus)
Release of platelet cytosolic components (Bos taurus)
Platelet releasate cytosolic proteins [cytosol] (Bos taurus)
VCL [cytosol] (Bos taurus)
Muscle contraction (Bos taurus)
Smooth Muscle Contraction (Bos taurus)
ATP Hydrolysis By Myosin (Bos taurus)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Bos taurus)
integrin:cytoskeletal adhesion complex [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Bos taurus)
integrin:cytoskeletal adhesion complex [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
Calcium Binds Caldesmon (Bos taurus)
Calcium Bound Myosin Actin Complex [plasma membrane] (Bos taurus)
integrin:cytoskeletal adhesion complex [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
Inactive Myosin Actin Contractile Complex [plasma membrane] (Bos taurus)
integrin:cytoskeletal adhesion complex [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
Myosin Binds ATP (Bos taurus)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Bos taurus)
integrin:cytoskeletal adhesion complex [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Bos taurus)
integrin:cytoskeletal adhesion complex [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
Release Of ADP From Myosin (Bos taurus)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Bos taurus)
integrin:cytoskeletal adhesion complex [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
Calcium Bound Myosin Actin Complex [plasma membrane] (Bos taurus)
integrin:cytoskeletal adhesion complex [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
MAP2K and MAPK activation (Bos taurus)
Dissociation of RAS:RAF complex (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
Dual mechanism MAPK inhibitors bind MAPKs (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
MAP2Ks and MAPKs bind to the activated RAF complex (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
MAP2Ks phosphorylate MAPKs (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
RAF phosphorylates MAP2K dimer (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
VCL [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:F1N789
Gene Names
VCL
Reference Genes
BioGPS Gene:783645 VCL
ENSEMBL:ENSBTAG00000021879.7
KEGG Gene (Bos taurus):783645 VCL
Monarch:783645 VCL
NCBI Gene:783645 VCL
Reference Transcript
RefSeq:NM_001191370.1 VCL
Other Identifiers
783645
GO:0002102
GO:0003779
GO:0005198
GO:0005737
GO:0005856
GO:0005886
GO:0005912
GO:0005925
GO:0007155
GO:0008013
GO:0008092
GO:0015629
GO:0016020
GO:0043226
GO:0044291
GO:0045294
GO:0051015
GO:0070161
Participates
as a component of
integrin:cytoskeletal adhesion complex [plasma membrane] (Bos taurus)
Vinculin bound to PIP2 [plasma membrane] (Bos taurus)
as a member of
Platelet releasate cytosolic proteins [cytosol] (Bos taurus)
Other forms of this molecule
VCL [specific granule lumen]
VCL [secretory granule lumen]
VCL [extracellular region]
VCL [ficolin-1-rich granule lumen]
Inferred From
VCL [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001178299.1
OpenTargets
ENSG00000035403
Ensembl
ENSBTAT00000061210
,
ENSBTAG00000021879
,
ENSBTAP00000053644
VGNC
36779
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