Reactome | phospho-p-Y397-PTK2 [cytosol]

phospho-p-Y397-PTK2 [cytosol]

Stable Identifier

R-BTA-354068

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

A0A3Q1N508

Locations in the PathwayBrowser

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Developmental Biology (Bos taurus)

- Nervous system development (Bos taurus)
  - Axon guidance (Bos taurus)
    - EPH-Ephrin signaling (Bos taurus)
      - EPHB-mediated forward signaling (Bos taurus)
        
        Recruitment of p190RhoGEF to p-FAK (Bos taurus)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Bos taurus)
        
        phospho-p-Y397-PTK2 [cytosol] (Bos taurus)
        
        EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Bos taurus)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Bos taurus)
        
        phospho-p-Y397-PTK2 [cytosol] (Bos taurus)
        
        p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Bos taurus)
        
        EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Bos taurus)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Bos taurus)
        
        phospho-p-Y397-PTK2 [cytosol] (Bos taurus)
    - Netrin-1 signaling (Bos taurus)
      - DCC mediated attractive signaling (Bos taurus)
        
        Activation of Cdc42 (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Bos taurus)
        
        phospho-p-Y397-PTK2 [cytosol] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Bos taurus)
        
        phospho-p-Y397-PTK2 [cytosol] (Bos taurus)
        
        Activation of Rac1 (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Bos taurus)
        
        phospho-p-Y397-PTK2 [cytosol] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Bos taurus)
        
        phospho-p-Y397-PTK2 [cytosol] (Bos taurus)
        
        DCC interacting NCK-1 (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Bos taurus)
        
        phospho-p-Y397-PTK2 [cytosol] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Bos taurus)
        
        phospho-p-Y397-PTK2 [cytosol] (Bos taurus)
        
        Phosphorylation of DCC by Fyn (Bos taurus)
        
        NTN1:DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Bos taurus)
        
        NTN1:DCC oligomer:p-Y397-PTK2 [plasma membrane] (Bos taurus)
        
        phospho-p-Y397-PTK2 [cytosol] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Bos taurus)
        
        phospho-p-Y397-PTK2 [cytosol] (Bos taurus)
        
        Recruitment and activation of N-WASP by Cdc42 (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Bos taurus)
        
        phospho-p-Y397-PTK2 [cytosol] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Bos taurus)
        
        phospho-p-Y397-PTK2 [cytosol] (Bos taurus)
        
        RhoGTPase GEF's recruited to DCC (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Bos taurus)
        
        phospho-p-Y397-PTK2 [cytosol] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Bos taurus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Bos taurus)
        
        phospho-p-Y397-PTK2 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:A0A3Q1N508

Reference Genes

ENSEMBL:ENSBTAG00000009578.6

ENSEMBL:ENSBTAG00000009578.7

Other Identifiers

GO:0000166

GO:0001525

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005524

GO:0005856

GO:0005886

GO:0005925

GO:0005938

GO:0007155

GO:0007172

GO:0007173

GO:0008284

GO:0016020

GO:0016740

GO:0023052

GO:0030054

GO:0030155

GO:0030335

GO:0036211

GO:0042995

GO:0043197

GO:0043226

GO:0048856

GO:0048870

GO:0050896

GO:0051128

GO:0051239

GO:0065003

GO:0065008

GO:0070161

GO:0140096

Participates

as a component of

as an output of

Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow (Bos taurus)

This entity regulates

Positively

PTK2 (FAK) and Gq/11 enhance the degradation of NFKBIA (IkBalpha), phosphorylation of RELA (p65) on serine-536, and translocation of p-S536-RELA:NFKB1 (p65:p50) to the nucleus (Bos taurus)

Other forms of this molecule

phospho-pY-PTK2 [cytosol]

phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]

phospho-p-Y194,Y397-PTK2 [cytosol]

phospho-p-5Y-PTK2 [cytosol]

phospho-p-5Y,S732-PTK2 [cytosol]

phospho-p-6Y,S732-PTK2 [cytosol]

PTK2(773-1052) [cytosol]

PTK2(1-772) [cytosol]

PTK2 [cytosol]

phospho-p-6Y-PTK2 [cytosol]

Inferred From

p-Y397-PTK2 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 397 (in Homo sapiens)

Coordinate

397

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

Ensembl

ENSBTAP00000065036, ENSBTAG00000009578, ENSBTAT00000085237

VGNC

33518

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