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CRKL [cytosol]
Stable Identifier
R-BTA-354384
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
CRKL, G3N016
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
Regulation of signaling by CBL (Bos taurus)
CBL binds CRK (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRKL [cytosol] (Bos taurus)
p(Y700,731,774)-CBL:CRK [cytosol] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRKL [cytosol] (Bos taurus)
CBL:CRKL binds RAPGEF1 (Bos taurus)
p(Y700,731,774)-CBL:CRK [cytosol] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRKL [cytosol] (Bos taurus)
p(Y700,731,774)-CBL:CRK:RAPGEF1 [cytosol] (Bos taurus)
p(Y700,731,774)-CBL:CRK [cytosol] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRKL [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by MET (Bos taurus)
MET promotes cell motility (Bos taurus)
MET activates RAP1 and RAC1 (Bos taurus)
CRK,CRKL recruits RAC1 GEF to activated MET (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRKL [cytosol] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRKL [cytosol] (Bos taurus)
DOCK7 activates RAC1 (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRKL [cytosol] (Bos taurus)
GAB1 recruits CRK,CRKL to MET (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRKL [cytosol] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRKL [cytosol] (Bos taurus)
RAPGEF1 activates RAP1 (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRKL [cytosol] (Bos taurus)
RAPGEF1 binds CRK,CRKL (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRKL [cytosol] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRKL [cytosol] (Bos taurus)
MET receptor recycling (Bos taurus)
GGA3 associates with activated MET receptor (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRKL [cytosol] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRKL [cytosol] (Bos taurus)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRKL [cytosol] (Bos taurus)
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
Signalling to ERKs (Bos taurus)
Prolonged ERK activation events (Bos taurus)
Frs2-mediated activation (Bos taurus)
p-FRS2:CRKL binds C3G (Bos taurus)
Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Bos taurus)
CRKL [cytosol] (Bos taurus)
Active TrkA receptor:p-FRS2:CRKL:RAPGEF1 [endosome membrane] (Bos taurus)
Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Bos taurus)
CRKL [cytosol] (Bos taurus)
Signaling by PDGF (Bos taurus)
Downstream signal transduction (Bos taurus)
Crk binds to the active PDGF receptor (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRKL [cytosol] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRKL [cytosol] (Bos taurus)
p130Cas and C3G bind PDGFR bound Crk (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRKL [cytosol] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Bos taurus)
CRK, CRKL [cytosol] (Bos taurus)
CRKL [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:G3N016
Gene Names
CRKL
Reference Genes
ENSEMBL:ENSBTAG00000045548.2
Other Identifiers
GO:0007165
GO:0016477
GO:0023052
GO:0030971
GO:0035591
GO:0048870
GO:0060090
GO:0070374
GO:2000145
Participates
as a member of
CRK, CRKL [cytosol] (Bos taurus)
as a component of
Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Bos taurus)
Other forms of this molecule
phospho-CRKL [cytosol]
Inferred From
CRKL [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000099942
Ensembl
ENSBTAP00000055171
,
ENSBTAT00000066024
,
ENSBTAG00000045548
VGNC
53897
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