Reactome | SLC18A3 [plasma membrane]

SLC18A3 [plasma membrane]

Stable Identifier

R-BTA-372513

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

plasma membrane

Synonyms

SLC18A3, E1BK36

Locations in the PathwayBrowser

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Vesicle-mediated transport (Bos taurus)

- Membrane Trafficking (Bos taurus)
  - Clathrin-mediated endocytosis (Bos taurus)
    - BAR domain proteins recruit dynamin (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        SLC18A3 [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        SLC18A3 [plasma membrane] (Bos taurus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Bos taurus)
      - CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        SLC18A3 [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        SLC18A3 [plasma membrane] (Bos taurus)
    - Cargo recognition for clathrin-mediated endocytosis (Bos taurus)
      - AP-2 directly binds some endocytic cargo (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        SLC18A3 [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        SLC18A3 [plasma membrane] (Bos taurus)
    - Clathrin recruits PIK3C2A (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        SLC18A3 [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        SLC18A3 [plasma membrane] (Bos taurus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        SLC18A3 [plasma membrane] (Bos taurus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        SLC18A3 [plasma membrane] (Bos taurus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        SLC18A3 [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        SLC18A3 [plasma membrane] (Bos taurus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        SLC18A3 [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        SLC18A3 [plasma membrane] (Bos taurus)
    - SNX9 recruits components of the actin polymerizing machinery (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        SLC18A3 [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        SLC18A3 [plasma membrane] (Bos taurus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        SLC18A3 [plasma membrane] (Bos taurus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        CLASP proteins:cargo [plasma membrane] (Bos taurus)
        
        AP-2:cargo [plasma membrane] (Bos taurus)
        
        AP-2 cargo [plasma membrane] (Bos taurus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)
        
        SLC18A3 [plasma membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:E1BK36

Gene Names

SLC18A3

Reference Genes

BioGPS Gene:785833 SLC18A3

ENSEMBL:ENSBTAG00000014990.6

KEGG:bta:785833 SLC18A3

Monarch:785833 SLC18A3

NCBI Gene:785833 SLC18A3

UCSC:E1BK36 SLC18A3

Reference Transcript

Other Identifiers

785833

Bt.26067.1.A1_at

GO:0005215

GO:0005277

GO:0005278

GO:0006836

GO:0007268

GO:0015311

GO:0016020

GO:0022857

GO:0023052

GO:0030121

GO:0030122

GO:0030672

GO:0043195

GO:0051610

GO:0051630

GO:0055085

GO:1902600

Participates

as a member of

AP-2 YXXPhi cargo [plasma membrane] (Bos taurus)

as an output of

Release of acetylcholine at the synapse (Bos taurus)

Other forms of this molecule

SLC18A3 [clathrin-coated endocytic vesicle membrane]

SLC18A3 [clathrin-sculpted acetylcholine transport vesicle membrane]

Inferred From

SLC18A3 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_002699016.1, XP_001253716.2

ENSEMBL

ENSBTAT00000019955, ENSBTAP00000019955, ENSBTAG00000014990

VGNC

34707

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