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DOCK1 [cytosol]
Stable Identifier
R-BTA-372654
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
DOCK1, F1MIX6
Locations in the PathwayBrowser
Expand all
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
Netrin-1 signaling (Bos taurus)
DCC mediated attractive signaling (Bos taurus)
Activation of Cdc42 (Bos taurus)
DOCK1,TRIO [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Bos taurus)
DOCK1,TRIO [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Bos taurus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Bos taurus)
DOCK1,TRIO [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
Activation of Rac1 (Bos taurus)
DOCK1,TRIO [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Bos taurus)
DOCK1,TRIO [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Bos taurus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Bos taurus)
DOCK1,TRIO [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
Recruitment and activation of N-WASP by Cdc42 (Bos taurus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Bos taurus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Bos taurus)
DOCK1,TRIO [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Bos taurus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Bos taurus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Bos taurus)
DOCK1,TRIO [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
RhoGTPase GEF's recruited to DCC (Bos taurus)
DOCK1,TRIO [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Bos taurus)
DOCK1,TRIO [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
Hemostasis (Bos taurus)
Factors involved in megakaryocyte development and platelet production (Bos taurus)
DOCKs bind to RhoGEFs (Bos taurus)
DOCK-GEFs [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
DOCK-GEFs:RAC1, CDC42 [cytosol] (Bos taurus)
DOCK-GEFs [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
Activation of RAC1 by CRKII:DOCK180:ELMO (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Non-Receptor Tyrosine Kinases (Bos taurus)
Signaling by PTK6 (Bos taurus)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Bos taurus)
Activation of RAC1 by the PXN:CRK complex (Bos taurus)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
Phosphorylated PXN recruits the CRK complex (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
DOCK180:ELMO binds CRK (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase cycle (Bos taurus)
RAC1 GTPase cycle (Bos taurus)
RAC1 GEFs activate RAC1 (Bos taurus)
RAC1 GEFs [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
RAC2 GTPase cycle (Bos taurus)
RAC2 GEFs activate RAC2 (Bos taurus)
RAC2 GEFs [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
RHOG GTPase cycle (Bos taurus)
RHOG binds effectors at the plasma membrane (Bos taurus)
RHOG plasma membrane effectors [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
RHOG:GTP:RHOG plasma membrane effectors [plasma membrane] (Bos taurus)
RHOG plasma membrane effectors [cytosol] (Bos taurus)
DOCK1 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:F1MIX6
Gene Names
DOCK1
Reference Genes
BioGPS Gene:537203 DOCK1
ENSEMBL:ENSBTAG00000031890.3
KEGG:bta:537203 DOCK1
Monarch:537203 DOCK1
NCBI Gene:537203 DOCK1
UCSC:F1MIX6 DOCK1
Reference Transcript
RefSeq:XM_015469652.1 DOCK1
RefSeq:XM_005225872.3 DOCK1
Other Identifiers
537203
GO:0002244
GO:0005654
GO:0005829
GO:0016477
GO:0016607
GO:0030154
GO:0048870
Participates
as a candidate of
RAC2 GEFs [cytosol] (Bos taurus)
RAC1 GEFs [cytosol] (Bos taurus)
as a member of
RHOG plasma membrane effectors [cytosol] (Bos taurus)
DOCK-GEFs [cytosol] (Bos taurus)
DOCK1,TRIO [cytosol] (Bos taurus)
as a component of
DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Bos taurus)
Inferred From
DOCK1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_015325138.1
,
XP_005225929.1
ENSEMBL
ENSBTAP00000032659
,
ENSBTAT00000032730
VGNC
28154
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