Reactome | ACKR3 [plasma membrane]

ACKR3 [plasma membrane]

Stable Identifier

R-BTA-373859

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

plasma membrane

Synonyms

CXCR7, A4IF77

Locations in the PathwayBrowser

Expand all

Signal Transduction (Bos taurus)

- Signaling by GPCR (Bos taurus)
  - GPCR downstream signalling (Bos taurus)
    - G alpha (i) signalling events (Bos taurus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Bos taurus)
        
        CXCR4,7 [plasma membrane] (Bos taurus)
        
        ACKR3 [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Bos taurus)
        
        CXCR4,7 [plasma membrane] (Bos taurus)
        
        ACKR3 [plasma membrane] (Bos taurus)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Bos taurus)
        
        CXCR4,7 [plasma membrane] (Bos taurus)
        
        ACKR3 [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Bos taurus)
        
        CXCR4,7 [plasma membrane] (Bos taurus)
        
        ACKR3 [plasma membrane] (Bos taurus)
      - The Ligand:GPCR:Gi complex dissociates (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Bos taurus)
        
        CXCR4,7 [plasma membrane] (Bos taurus)
        
        ACKR3 [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Bos taurus)
        
        CXCR4,7 [plasma membrane] (Bos taurus)
        
        ACKR3 [plasma membrane] (Bos taurus)
  - GPCR ligand binding (Bos taurus)
    - Class A/1 (Rhodopsin-like receptors) (Bos taurus)
      - Peptide ligand-binding receptors (Bos taurus)
        
        Chemokine receptors bind chemokines (Bos taurus)
        
        Receptors CXCR4 and 7 bind CXCL12 ligand (Bos taurus)
        
        CXCR4,7 [plasma membrane] (Bos taurus)
        
        ACKR3 [plasma membrane] (Bos taurus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Bos taurus)
        
        CXCR4,7 [plasma membrane] (Bos taurus)
        
        ACKR3 [plasma membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:A4IF77

Gene Names

ACKR3

Reference Genes

BioGPS Gene:509585 ACKR3

ENSEMBL:ENSBTAG00000018424.6

KEGG Gene (Bos taurus):509585 ACKR3

Monarch:509585 ACKR3

NCBI Gene:509585 ACKR3

Reference Transcript

RefSeq:NM_001098381.2 ACKR3

Other Identifiers

509585

GO:0001525

GO:0001570

GO:0002376

GO:0004930

GO:0005044

GO:0005768

GO:0005886

GO:0005905

GO:0006935

GO:0006955

GO:0007165

GO:0007186

GO:0007204

GO:0008285

GO:0009897

GO:0009986

GO:0012501

GO:0015026

GO:0016020

GO:0016192

GO:0016493

GO:0016494

GO:0019722

GO:0019956

GO:0019957

GO:0019958

GO:0021557

GO:0023052

GO:0030154

GO:0031410

GO:0031623

GO:0038024

GO:0043226

GO:0043231

GO:0048856

GO:0048870

GO:0060089

GO:0060326

GO:0070098

GO:0070374

GO:1902230

Participates

as a member of

CXCR4,7 [plasma membrane] (Bos taurus)

Inferred From

CXCR7 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001091851.1

OpenTargets

ENSG00000144476

Ensembl

ENSBTAP00000024512, ENSBTAG00000018424, ENSBTAT00000024512

VGNC

25541