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NR1H2 [nucleoplasm]
Stable Identifier
R-BTA-375500
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
nucleoplasm
Synonyms
NR1H2, Q5BIS6
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Nuclear Receptor transcription pathway (Bos taurus)
Formation of NR-MED1 Coactivator Complex (Bos taurus)
NR [nucleoplasm] (Bos taurus)
NR1H2 [nucleoplasm] (Bos taurus)
NR-MED1 Coactivator Complex [nucleoplasm] (Bos taurus)
NR [nucleoplasm] (Bos taurus)
NR1H2 [nucleoplasm] (Bos taurus)
Formation of NR-NCOR Corepressor Complex (Bos taurus)
NR [nucleoplasm] (Bos taurus)
NR1H2 [nucleoplasm] (Bos taurus)
NR-NCOR CoRepressor Complex [nucleoplasm] (Bos taurus)
NR [nucleoplasm] (Bos taurus)
NR1H2 [nucleoplasm] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
SUMOylation (Bos taurus)
SUMO E3 ligases SUMOylate target proteins (Bos taurus)
SUMOylation of intracellular receptors (Bos taurus)
HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Bos taurus)
NR1H2:hydroxycholesterol [nucleoplasm] (Bos taurus)
NR1H2 [nucleoplasm] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Nuclear Receptors (Bos taurus)
NR1H2 and NR1H3-mediated signaling (Bos taurus)
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis (Bos taurus)
Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene (Bos taurus)
UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand [nucleoplasm] (Bos taurus)
NR1H2,3:RXR [nucleoplasm] (Bos taurus)
NR1H2:RXRA [nucleoplasm] (Bos taurus)
NR1H2 [nucleoplasm] (Bos taurus)
UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOR [nucleoplasm] (Bos taurus)
NR1H2,3:RXR [nucleoplasm] (Bos taurus)
NR1H2:RXRA [nucleoplasm] (Bos taurus)
NR1H2 [nucleoplasm] (Bos taurus)
NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Bos taurus)
UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand [nucleoplasm] (Bos taurus)
NR1H2,3:RXR [nucleoplasm] (Bos taurus)
NR1H2:RXRA [nucleoplasm] (Bos taurus)
NR1H2 [nucleoplasm] (Bos taurus)
UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOA1 [nucleoplasm] (Bos taurus)
NR1H2,3:RXR [nucleoplasm] (Bos taurus)
NR1H2:RXRA [nucleoplasm] (Bos taurus)
NR1H2 [nucleoplasm] (Bos taurus)
Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Bos taurus)
UGT1A3 gene:NR1H2,3:RXR:NCOR [nucleoplasm] (Bos taurus)
NR1H2,3:RXR [nucleoplasm] (Bos taurus)
NR1H2:RXRA [nucleoplasm] (Bos taurus)
NR1H2 [nucleoplasm] (Bos taurus)
UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOR [nucleoplasm] (Bos taurus)
NR1H2,3:RXR [nucleoplasm] (Bos taurus)
NR1H2:RXRA [nucleoplasm] (Bos taurus)
NR1H2 [nucleoplasm] (Bos taurus)
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux (Bos taurus)
Co-repressor complex dissociates from the transcription unit of the ABCA1 gene (Bos taurus)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands [nucleoplasm] (Bos taurus)
NR1H2,3:RXR [nucleoplasm] (Bos taurus)
NR1H2:RXRA [nucleoplasm] (Bos taurus)
NR1H2 [nucleoplasm] (Bos taurus)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Bos taurus)
NR1H2,3:RXR [nucleoplasm] (Bos taurus)
NR1H2:RXRA [nucleoplasm] (Bos taurus)
NR1H2 [nucleoplasm] (Bos taurus)
NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Bos taurus)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands [nucleoplasm] (Bos taurus)
NR1H2,3:RXR [nucleoplasm] (Bos taurus)
NR1H2:RXRA [nucleoplasm] (Bos taurus)
NR1H2 [nucleoplasm] (Bos taurus)
NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Bos taurus)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands [nucleoplasm] (Bos taurus)
NR1H2,3:RXR [nucleoplasm] (Bos taurus)
NR1H2:RXRA [nucleoplasm] (Bos taurus)
NR1H2 [nucleoplasm] (Bos taurus)
NCOA1 recruits EP300 to the ABCA1 promoter (Bos taurus)
EP300:NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Bos taurus)
NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Bos taurus)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands [nucleoplasm] (Bos taurus)
NR1H2,3:RXR [nucleoplasm] (Bos taurus)
NR1H2:RXRA [nucleoplasm] (Bos taurus)
NR1H2 [nucleoplasm] (Bos taurus)
NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Bos taurus)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands [nucleoplasm] (Bos taurus)
NR1H2,3:RXR [nucleoplasm] (Bos taurus)
NR1H2:RXRA [nucleoplasm] (Bos taurus)
NR1H2 [nucleoplasm] (Bos taurus)
Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Bos taurus)
ABCA1gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Bos taurus)
NR1H2,3:RXR [nucleoplasm] (Bos taurus)
NR1H2:RXRA [nucleoplasm] (Bos taurus)
NR1H2 [nucleoplasm] (Bos taurus)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Bos taurus)
NR1H2,3:RXR [nucleoplasm] (Bos taurus)
NR1H2:RXRA [nucleoplasm] (Bos taurus)
NR1H2 [nucleoplasm] (Bos taurus)
Transport of small molecules (Bos taurus)
Plasma lipoprotein assembly, remodeling, and clearance (Bos taurus)
Plasma lipoprotein clearance (Bos taurus)
VLDLR internalisation and degradation (Bos taurus)
MYLIP dimer ubiquitinates VLDLR on Lys-839 (Bos taurus)
NR1H2,NR1H3 [nucleoplasm] (Bos taurus)
NR1H2 [nucleoplasm] (Bos taurus)
External Reference Information
External Reference
UniProt:Q5BIS6
Gene Names
NR1H2
Reference Genes
BioGPS Gene:509622 NR1H2
ENSEMBL:ENSBTAG00000003264
ENSEMBL:ENSBTAG00000003264.6 NR1H2
Monarch:509622 NR1H2
NCBI Gene:509622 NR1H2
Reference Transcript
RefSeq:XM_005219229.3 NR1H2
Other Identifiers
509622
GO:0000122
GO:0000978
GO:0001228
GO:0003677
GO:0003700
GO:0004879
GO:0005634
GO:0005737
GO:0006351
GO:0006355
GO:0006357
GO:0006629
GO:0010867
GO:0010875
GO:0010884
GO:0010887
GO:0016192
GO:0022600
GO:0023052
GO:0031490
GO:0032369
GO:0032376
GO:0034191
GO:0036151
GO:0042632
GO:0043226
GO:0044255
GO:0045723
GO:0045861
GO:0045892
GO:0045893
GO:0045944
GO:0046965
GO:0048550
GO:0051117
GO:0051247
GO:0055088
GO:0060089
GO:0065003
GO:0090108
GO:0090187
GO:0090340
GO:0090575
GO:0120163
GO:0140110
GO:1902895
GO:1903573
Participates
as a component of
NR1H2:hydroxycholesterol [nucleoplasm] (Bos taurus)
NR1H2:RXRA [nucleoplasm] (Bos taurus)
as a member of
NR1H2,NR1H3 [nucleoplasm] (Bos taurus)
NR [nucleoplasm] (Bos taurus)
Other forms of this molecule
NR1H2 [cytosol]
NR1H2 [nucleoplasm]
Inferred From
NR1H2 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_005219286.1
OpenTargets
ENSG00000131408
Ensembl
ENSBTAT00000004229
,
ENSBTAP00000004229
,
ENSBTAG00000003264
VGNC
32230
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