Reactome | CEP135 [cytosol]

CEP135 [cytosol]

Stable Identifier

R-BTA-380266

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

CEP135, F1ME99

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Bos taurus)

- Cilium Assembly (Bos taurus)
  - Anchoring of the basal body to the plasma membrane (Bos taurus)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Bos taurus)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        CEP135 [cytosol] (Bos taurus)
      - mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        CEP135 [cytosol] (Bos taurus)
    - C2CD3 binds the mother centriole (Bos taurus)
      - mother centriole [cytosol] (Bos taurus)
        
        CEP135 [cytosol] (Bos taurus)
      - mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        CEP135 [cytosol] (Bos taurus)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Bos taurus)
      - basal body:transition zone proteins [cytosol] (Bos taurus)
        
        basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        CEP135 [cytosol] (Bos taurus)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Bos taurus)
        
        basal body:transition zone proteins [cytosol] (Bos taurus)
        
        basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        CEP135 [cytosol] (Bos taurus)
    - CP110 and CEP97 dissociate from the centriole (Bos taurus)
      - basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        CEP135 [cytosol] (Bos taurus)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        CEP135 [cytosol] (Bos taurus)
    - MARK4 binds ODF2 in the centriole (Bos taurus)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        CEP135 [cytosol] (Bos taurus)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        CEP135 [cytosol] (Bos taurus)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Bos taurus)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Bos taurus)
        
        basal body:transition zone proteins [cytosol] (Bos taurus)
        
        basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        CEP135 [cytosol] (Bos taurus)
    - Recruitment of transition zone proteins (Bos taurus)
      - basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        CEP135 [cytosol] (Bos taurus)
      - basal body:transition zone proteins [cytosol] (Bos taurus)
        
        basal body [cytosol] (Bos taurus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Bos taurus)
        
        CEP135 [cytosol] (Bos taurus)
    - The distal appendage proteins recruit TTBK2 (Bos taurus)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        CEP135 [cytosol] (Bos taurus)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Bos taurus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Bos taurus)
        
        mother centriole:C2CD3 [cytosol] (Bos taurus)
        
        mother centriole [cytosol] (Bos taurus)
        
        CEP135 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:F1ME99

Gene Names

CEP135

Reference Genes

ENSEMBL:ENSBTAG00000009471.6

Other Identifiers

509483

GO:0005813

GO:0005814

GO:0005815

GO:0005856

GO:0007010

GO:0007099

GO:0008017

GO:0008092

GO:0010457

GO:0015631

GO:0042802

GO:0042803

GO:0043226

GO:0044782

GO:1902857

GO:1904951

Participates

as a component of

Inferred From

CEP135 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000174799

Ensembl

ENSBTAT00000012468, ENSBTAG00000009471, ENSBTAP00000012468

VGNC

27193

Cite Us!