Reactome | MC2R [plasma membrane]

MC2R [plasma membrane]

Stable Identifier

R-BTA-388600

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

plasma membrane

Synonyms

MC2R, P34974

Locations in the PathwayBrowser

Expand all

Signal Transduction (Bos taurus)

- Signaling by GPCR (Bos taurus)
  - GPCR downstream signalling (Bos taurus)
    - G alpha (s) signalling events (Bos taurus)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Bos taurus)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Bos taurus)
        
        POMC(138-176):MC2R [plasma membrane] (Bos taurus)
        
        MC2R [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Bos taurus)
        
        POMC(138-176):MC2R [plasma membrane] (Bos taurus)
        
        MC2R [plasma membrane] (Bos taurus)
  - GPCR ligand binding (Bos taurus)
    - Class A/1 (Rhodopsin-like receptors) (Bos taurus)
      - Peptide ligand-binding receptors (Bos taurus)
        
        POMC(138-176) binds MC2R (Bos taurus)
        
        MC2R [plasma membrane] (Bos taurus)
        
        POMC(138-176):MC2R [plasma membrane] (Bos taurus)
        
        MC2R [plasma membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:P34974

Gene Names

MC2R

Reference Genes

BioGPS Gene:281299 MC2R

ENSEMBL:ENSBTAG00000011038

ENSEMBL:ENSBTAG00000011038.5 MC2R

KEGG Gene (Bos taurus):281299 MC2R

Monarch:281299 MC2R

NCBI Gene:281299 MC2R

Reference Transcript

RefSeq:NM_174109.2 MC2R

Other Identifiers

281299

GO:0004930

GO:0004977

GO:0004978

GO:0005737

GO:0005886

GO:0007165

GO:0007186

GO:0007189

GO:0007218

GO:0016020

GO:0019222

GO:0023052

GO:0060089

Participates

as an input of

POMC(138-176) binds MC2R (Bos taurus)

as a component of

POMC(138-176):MC2R [plasma membrane] (Bos taurus)

Inferred From

MC2R [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_776534.1

OpenTargets

ENSG00000185231

Ensembl

ENSBTAG00000011038, ENSBTAP00000014661, ENSBTAT00000014661

VGNC

31293

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