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CHRM2 [plasma membrane]
Stable Identifier
R-BTA-390654
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
plasma membrane
Synonyms
CHRM2, P41985
Locations in the PathwayBrowser
Expand all
Signal Transduction (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Bos taurus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
CHRM2,CHRM4:AcCho [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
CHRM2,CHRM4:AcCho [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
CHRM2,CHRM4:AcCho [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
CHRM2,CHRM4:AcCho [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
The Ligand:GPCR:Gi complex dissociates (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
CHRM2,CHRM4:AcCho [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
CHRM2,CHRM4:AcCho [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
GPCR ligand binding (Bos taurus)
Class A/1 (Rhodopsin-like receptors) (Bos taurus)
Amine ligand-binding receptors (Bos taurus)
Muscarinic acetylcholine receptors (Bos taurus)
CHRM2 binds CHRM2 antagonists (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
CHRM2:CHRM2 antagonists [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
CHRM2,4 bind acetylcholine (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
CHRM2,CHRM4:AcCho [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
Vesicle-mediated transport (Bos taurus)
Membrane Trafficking (Bos taurus)
Clathrin-mediated endocytosis (Bos taurus)
BAR domain proteins recruit dynamin (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
Cargo recognition for clathrin-mediated endocytosis (Bos taurus)
ARBB recruits GPCRs into clathrin-coated pits (Bos taurus)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
ARRB bind GPCRs (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
Clathrin recruits PIK3C2A (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
Endophilins recruit synaptojanins to the clathrin-coated pit (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
F- and N- BAR domain proteins bind the clathrin-coated pit (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
SNX9 recruits components of the actin polymerizing machinery (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
ARRB:ARRB-binding GPCRs [plasma membrane] (Bos taurus)
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
CHRM2 [plasma membrane] (Bos taurus)
External Reference Information
External Reference
UniProt:P41985
Gene Names
CHRM2
Reference Genes
BioGPS Gene:522170 CHRM2
ENSEMBL:ENSBTAG00000014674
KEGG Gene (Bos taurus):522170 CHRM2
Monarch:522170 CHRM2
NCBI Gene:522170 CHRM2
Reference Transcript
RefSeq:NM_001080733.1 CHRM2
RefSeq:XM_005205852.3 CHRM2
Other Identifiers
522170
GO:0003013
GO:0004930
GO:0005886
GO:0007186
GO:0007213
GO:0008016
GO:0009615
GO:0016020
GO:0016907
GO:0023052
GO:0060089
GO:0098981
GO:0099171
GO:1990763
Participates
as a member of
ARRB-binding GPCRs [plasma membrane] (Bos taurus)
as an input of
CHRM2 binds CHRM2 antagonists (Bos taurus)
CHRM2,4 bind acetylcholine (Bos taurus)
as a component of
CHRM2:CHRM2 antagonists [plasma membrane] (Bos taurus)
CHRM2,CHRM4:AcCho [plasma membrane] (Bos taurus)
Other forms of this molecule
CHRM2 [clathrin-coated endocytic vesicle membrane]
Inferred From
CHRM2,CHRM4 [plasma membrane]
(Homo sapiens)
CHRM2 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
XP_005205909.1
,
NP_001074202.1
OpenTargets
ENSG00000181072
Ensembl
ENSBTAP00000019534
,
ENSBTAG00000014674
,
ENSBTAT00000019534
VGNC
27319
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