Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi

Stable Identifier
R-BTA-391533
Type
Reaction [dissociation]
Species
Bos taurus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi
Beta tubulin within the active (Factor E:alpha tubulin: Factor D:beta tubulin:Factor C )-supercomplex hydrolyzes GTP. This results in the dissociation of the complex and the release of the native tubulin heterodimer (Tian et al., 1997).
Literature References
PubMed ID Title Journal Year
9265649 Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors

Rommelaere, H, Lewis, SA, Stearns, T, Cowan, NJ, Feierbach, B, Tian, G, Ampe, C

J Cell Biol 1997
Participants
Input
Output
Orthologous Events
Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi (Homo sapiens)
Authored
Cowan, NJ  (2009-01-21)
Reviewed
Cowan, NJ  (2009-01-21)
Created
Matthews, L  (2009-02-23)
Cite Us!