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CUL2 [cytosol]
Stable Identifier
R-BTA-416982
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
CUL2, Q08DE9
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to hypoxia (Bos taurus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Bos taurus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Bos taurus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
Proteasome proteolyzes ub-HIF-alpha (Bos taurus)
VBC complex (with or without LIMD1) [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
Polyubiquitination of substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
Release of E3 from polyubiquitinated substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Neddylation (Bos taurus)
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Bos taurus)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Bos taurus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Bos taurus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
CRL2 E3 ubiquitin ligase [cytosol] (Bos taurus)
CUL2 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q08DE9
Gene Names
CUL2
Reference Genes
BioGPS Gene:535219 CUL2
ENSEMBL:ENSBTAG00000007133.6
KEGG:bta:535219 CUL2
Monarch:535219 CUL2
NCBI Gene:535219 CUL2
UCSC:Q08DE9 CUL2
Reference Transcript
RefSeq:XM_005214225.5 CUL2
RefSeq:NM_001076909.1 CUL2
RefSeq:XM_005214224.5 CUL2
RefSeq:XM_025000723.2 CUL2
RefSeq:XM_005214227.5 CUL2
Participates
as a component of
CRL2 E3 ubiquitin ligase [cytosol] (Bos taurus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Bos taurus)
Other forms of this molecule
CUL2 [cytosol]
CUL2 [nucleoplasm]
Inferred From
CUL2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_005214281.1
,
XP_024856491.1
,
NP_001070377.1
,
XP_005214282.1
,
XP_005214284.1
VGNC
27830
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