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FANCA [nucleoplasm]
Stable Identifier
R-BTA-419541
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
nucleoplasm
Synonyms
FANCA, E1B6X8
Locations in the PathwayBrowser
Expand all
DNA Repair (Bos taurus)
Fanconi Anemia Pathway (Bos taurus)
ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Bos taurus)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Bos taurus)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
FA Core Complex [nucleoplasm] (Bos taurus)
FANCA [nucleoplasm] (Bos taurus)
p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
p-FA Core Complex [nucleoplasm] (Bos taurus)
FANCA [nucleoplasm] (Bos taurus)
DNA nucleases bind monoubiquitinated ID2 complex (Bos taurus)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
p-FA Core Complex [nucleoplasm] (Bos taurus)
FANCA [nucleoplasm] (Bos taurus)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Bos taurus)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
p-FA Core Complex [nucleoplasm] (Bos taurus)
FANCA [nucleoplasm] (Bos taurus)
DNA nucleases unhook the interstrand crosslink (ICL) (Bos taurus)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Bos taurus)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
p-FA Core Complex [nucleoplasm] (Bos taurus)
FANCA [nucleoplasm] (Bos taurus)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Bos taurus)
FA core complex [nucleoplasm] (Bos taurus)
FANCA [nucleoplasm] (Bos taurus)
FA core complex assembles at DNA interstrand crosslinks (ICLs) (Bos taurus)
FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
FA Core Complex [nucleoplasm] (Bos taurus)
FANCA [nucleoplasm] (Bos taurus)
FANCA [nucleoplasm] (Bos taurus)
FANCD2 deubiquitination by USP1:WDR48 (Bos taurus)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
p-FA Core Complex [nucleoplasm] (Bos taurus)
FANCA [nucleoplasm] (Bos taurus)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
p-FA Core Complex [nucleoplasm] (Bos taurus)
FANCA [nucleoplasm] (Bos taurus)
FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Bos taurus)
FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
FA Core Complex [nucleoplasm] (Bos taurus)
FANCA [nucleoplasm] (Bos taurus)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
FA Core Complex [nucleoplasm] (Bos taurus)
FANCA [nucleoplasm] (Bos taurus)
Monoubiquitination of FANCD2:FANCI (Bos taurus)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
p-FA Core Complex [nucleoplasm] (Bos taurus)
FANCA [nucleoplasm] (Bos taurus)
p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
p-FA Core Complex [nucleoplasm] (Bos taurus)
FANCA [nucleoplasm] (Bos taurus)
POLN binds ICL-DNA (Bos taurus)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Bos taurus)
FA core complex [nucleoplasm] (Bos taurus)
FANCA [nucleoplasm] (Bos taurus)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Bos taurus)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Bos taurus)
FA core complex [nucleoplasm] (Bos taurus)
FANCA [nucleoplasm] (Bos taurus)
The complex of ATR and ATRIP is recruited to ICL-DNA (Bos taurus)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
FA Core Complex [nucleoplasm] (Bos taurus)
FANCA [nucleoplasm] (Bos taurus)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Bos taurus)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
FA Core Complex:ICL-DNA [nucleoplasm] (Bos taurus)
FA Core Complex [nucleoplasm] (Bos taurus)
FANCA [nucleoplasm] (Bos taurus)
Translesion synthesis across unhooked ICL by POLN (Bos taurus)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Bos taurus)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Bos taurus)
FA core complex [nucleoplasm] (Bos taurus)
FANCA [nucleoplasm] (Bos taurus)
p-FA Core Complex [nucleoplasm] (Bos taurus)
FANCA [nucleoplasm] (Bos taurus)
External Reference Information
External Reference
UniProt:E1B6X8
Gene Names
FANCA
Reference Genes
BioGPS Gene:618375 FANCA
ENSEMBL:ENSBTAG00000001906.6
ENSEMBL:ENSBTAG00000001906.7 FANCA
KEGG Gene (Bos taurus):618375 FANCA
Monarch:618375 FANCA
NCBI Gene:618375 FANCA
Reference Transcript
RefSeq:NM_001206603.1 FANCA
RefSeq:XM_015475777.1 FANCA
Other Identifiers
618375
Participates
as a component of
FA core complex [nucleoplasm] (Bos taurus)
p-FA Core Complex [nucleoplasm] (Bos taurus)
FA Core Complex [nucleoplasm] (Bos taurus)
as an input of
FA core complex assembles at DNA interstrand crosslinks (ICLs) (Bos taurus)
Other forms of this molecule
FANCA [cytosol]
Inferred From
FANCA [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_015331263.1
,
NP_001193532.1
OpenTargets
ENSG00000187741
Ensembl
ENSBTAP00000002478
,
ENSBTAG00000001906
,
ENSBTAT00000002478
VGNC
28852
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