Reactome | IL1RAP [plasma membrane]

IL1RAP [plasma membrane]

Stable Identifier

R-BTA-445745

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

plasma membrane

Synonyms

IL1RAP-1, E1BFL8

Locations in the PathwayBrowser

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Signal Transduction (Bos taurus)

- Intracellular signaling by second messengers (Bos taurus)
  - PIP3 activates AKT signaling (Bos taurus)
    - Negative regulation of the PI3K/AKT network (Bos taurus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
        
        PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Bos taurus)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Bos taurus)
        
        IL33:IL1RL1:IL1RAP-1 [plasma membrane] (Bos taurus)
        
        IL1RAP [plasma membrane] (Bos taurus)
    - PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
      - IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Bos taurus)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Bos taurus)
        
        IL33:IL1RL1:IL1RAP-1 [plasma membrane] (Bos taurus)
        
        IL1RAP [plasma membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:E1BFL8

Gene Names

IL1RAP

Reference Genes

BioGPS Gene:539334 IL1RAP

ENSEMBL:ENSBTAG00000013205.6

Monarch:539334 IL1RAP

NCBI Gene:539334 IL1RAP

Reference Transcript

Other Identifiers

GO:0003824

GO:0004908

GO:0006954

GO:0007165

GO:0016020

GO:0016787

GO:0019221

GO:0023052

GO:0060089

Participates

as an input of

as a component of

Inferred From

IL1RAP-1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_010799535.1, XP_005201572.1

OpenTargets

ENSG00000196083

Ensembl

ENSBTAG00000068007, ENSBTAT00000046134, ENSBTAP00000043460

VGNC

30133

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