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What is Reactome ?
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K63polyUb [cytosol]
Stable Identifier
R-BTA-450152
Type
Polymer
Species
Bos taurus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 signaling (Bos taurus)
Pellino ubiquitinates IRAK1 (Bos taurus)
hp-IRAK1: p-Pellino-1,2,(3):UBE2N:UBE2V1:K63polyUb [cytosol] (Bos taurus)
UBE2N:UBE2V1:K63polyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
TRAF6 is K63 poly-ubiquitinated (Bos taurus)
hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb [cytosol] (Bos taurus)
UBE2N:UBE2V1:K63polyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Interleukin-17 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
TNFR2 non-canonical NF-kB pathway (Bos taurus)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
Alpha-protein kinase 1 signaling pathway (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Bos taurus)
NOD1/2 Signaling Pathway (Bos taurus)
CYLD deubiquitinates NEMO (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
RIP2 is K63 polyubiquitinated (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
TNFAIP3 (A20) deubiquitinates RIP2 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
IKK complex recruitment mediated by RIP1 (Bos taurus)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Bos taurus)
Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Activation of TAK1 complex bound to activated TLR4 complex (Bos taurus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Phosphorylated TAK1 leaves activated TLR receptor complex (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
IRAK2 mediated activation of TAK1 complex (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Deubiquitination (Bos taurus)
Josephin domain DUBs (Bos taurus)
ATXN3 deubiquitinates polyUb-PARK2 (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
ATXN3 family cleave Ub chains (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
PARK2 autoubiquitinates (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Metalloprotease DUBs (Bos taurus)
BRISC complex deubiquitinates NLRP3 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
PSMD14 cleaves K63-linked ubiquitin (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
STAMBPL1 is a deubiquitinase (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Ovarian tumor domain proteases (Bos taurus)
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
TNFAIP3 (A20) deubiquitinates RIP2 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Ub-specific processing proteases (Bos taurus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
USP11 deubiquitinates NFKBIA (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
USP13 deubiquitinates BECN1,USP10 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
USP18 deubiquitinates TAK1:TAB1 (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
USP19 deubiquitinates RNF123 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
USP20, USP33 deubiquitinate ADRB2 (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
USP21 deubiquitinates RIPK1,DDX58 (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
USP25 deubiquitinates DDX58 (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
USP33 deubiquitinates CCP110,ARRB (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
USP4 deubiquitinate TRAF2,TRAF6 (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
USP5 cleaves polyubiquitin (Bos taurus)
USP5:PolyUb [cytosol] (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
TNF signaling (Bos taurus)
TNFR1-induced NF-kappa-B signaling pathway (Bos taurus)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
RAS processing (Bos taurus)
USP17L2 deubiquitinates RCE1 (Bos taurus)
PolyUb [cytosol] (Bos taurus)
K63polyUb [cytosol] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
repeated unit
K63-Ub [cytosol]
(Bos taurus)
Participates
as an output of
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Bos taurus)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Bos taurus)
USP13 deubiquitinates BECN1,USP10 (Bos taurus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Bos taurus)
USP19 deubiquitinates RNF123 (Bos taurus)
BRISC complex deubiquitinates NLRP3 (Bos taurus)
ATXN3 family cleave Ub chains (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Bos taurus)
CYLD deubiquitinates NEMO (Bos taurus)
TNFAIP3 (A20) deubiquitinates RIP2 (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)
as an input of
STAMBPL1 is a deubiquitinase (Bos taurus)
PSMD14 cleaves K63-linked ubiquitin (Bos taurus)
ATXN3 family cleave Ub chains (Bos taurus)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Bos taurus)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Bos taurus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Bos taurus)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Bos taurus)
Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Bos taurus)
RIP2 is K63 polyubiquitinated (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Bos taurus)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Bos taurus)
as a member of
PolyUb [cytosol] (Bos taurus)
as a component of
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Bos taurus)
UBE2N:UBE2V1:K63polyUb [cytosol] (Bos taurus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Bos taurus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Bos taurus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Bos taurus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Bos taurus)
Inferred From
Short K63polyUb [cytosol]
(Homo sapiens)
K63polyUb [cytosol]
(Homo sapiens)
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