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activated TBK1/IKK epsilon [cytosol]
Stable Identifier
R-BTA-450251
Type
Set [DefinedSet]
Species
Bos taurus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF(TICAM1)-mediated TLR4 signaling (Bos taurus)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (Bos taurus)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Bos taurus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Bos taurus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Bos taurus)
activated TBK1/IKK epsilon [cytosol] (Bos taurus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Bos taurus)
activated TBK1/IKK epsilon [cytosol] (Bos taurus)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Bos taurus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Bos taurus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Bos taurus)
activated TBK1/IKK epsilon [cytosol] (Bos taurus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Bos taurus)
activated TBK1/IKK epsilon [cytosol] (Bos taurus)
Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation (Bos taurus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Bos taurus)
activated TBK1/IKK epsilon [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
TNF signaling (Bos taurus)
Regulation of TNFR1 signaling (Bos taurus)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
activated TBK1/IKK epsilon [cytosol] (Bos taurus)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
activated TBK1/IKK epsilon [cytosol] (Bos taurus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
activated TBK1/IKK epsilon [cytosol] (Bos taurus)
activated TBK1/IKK epsilon [cytosol] (Bos taurus)
TNFR1-induced proapoptotic signaling (Bos taurus)
TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Bos taurus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
activated TBK1/IKK epsilon [cytosol] (Bos taurus)
Participants
members
phospho-p-S172-IKBKE [cytosol]
(Bos taurus)
phospho-p-S172-TBK1 [cytosol]
(Bos taurus)
Participates
as a component of
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Bos taurus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Bos taurus)
Inferred From
activated TBK1/IKK epsilon [cytosol]
(Homo sapiens)
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