Reactome | CSF2 [extracellular region]

CSF2 [extracellular region]

Stable Identifier

R-BTA-517562

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

extracellular region

Synonyms

CSF2, P11052

Locations in the PathwayBrowser

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Immune System (Bos taurus)

- Cytokine Signaling in Immune system (Bos taurus)
  - Signaling by Interleukins (Bos taurus)
    - Interleukin-2 family signaling (Bos taurus)
      - Interleukin receptor SHC signaling (Bos taurus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Bos taurus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        Phosphorylated SHC1 recruits SHIP (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Bos taurus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
      - 14-3-3 zeta binding allows recruitment of PI3K (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(S585)-Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(S585)-Common beta chain:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(S585)-Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(S585)-Common beta chain:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
      - Activation of STAT5a/b by JAK2 (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
      - IL3RB is phosphorylated on Ser-585 (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(S585)-Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(S585)-Common beta chain:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
      - Interleukin receptor SHC signaling (Bos taurus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Bos taurus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        Phosphorylated SHC1 recruits SHIP (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Bos taurus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
      - JAK2 is phosphorylated, activated (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
      - Recruitment of SHC1 is mediated by Y593 of the common beta chain (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
      - SHP1 and SHP2 bind the common beta chain (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
      - SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593)-Bc [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
      - STAT5 is recruited by JAK2 (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
      - The receptor is activated (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        High affinity binding complexes of interleukin receptors using the Common beta chain [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
      - Tyrosine kinases phosphorylate the receptor (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        Tyrosine kinases that phosphorylate the Common beta chain [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
      - p-S585-IL3RB binds 14-3-3 proteins (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(S585)-Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(S585)-Common beta chain:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(S585)-Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(S585)-Common beta chain:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
      - p-STAT5 dissociates from the receptor complex (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, activated JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:Common beta chain:p-JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)

Signal Transduction (Bos taurus)

- MAPK family signaling cascades (Bos taurus)
  - MAPK1/MAPK3 signaling (Bos taurus)
    - RAF/MAP kinase cascade (Bos taurus)
      - RAS GEFs promote RAS nucleotide exchange (Bos taurus)
        
        RAS GEFs [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, p(Y593, 628)- Bc [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Bos taurus)
        
        GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)
        
        CSF2 [extracellular region] (Bos taurus)

External Reference Information

External Reference

UniProt:P11052

Gene Names

CSF2

Reference Genes

BioGPS Gene:281095 CSF2

ENSEMBL:ENSBTAG00000001570

ENSEMBL:ENSBTAG00000001570.4 CSF2

KEGG Gene (Bos taurus):281095 CSF2

Monarch:281095 CSF2

NCBI Gene:281095 CSF2

Reference Transcript

RefSeq:NM_174027.2 CSF2

Other Identifiers

281095

GO:0001892

GO:0002376

GO:0005125

GO:0005129

GO:0005576

GO:0005615

GO:0005886

GO:0006351

GO:0006355

GO:0006955

GO:0007259

GO:0008083

GO:0008283

GO:0008284

GO:0010468

GO:0010628

GO:0010744

GO:0012501

GO:0023052

GO:0030154

GO:0030223

GO:0030224

GO:0030225

GO:0030526

GO:0032747

GO:0036211

GO:0038157

GO:0042127

GO:0042531

GO:0043011

GO:0043226

GO:0043231

GO:0045892

GO:0048018

GO:0048856

GO:0065003

GO:0070665

GO:0071803

GO:0097011

GO:0097028

GO:0098772

GO:2001240

Participates

as a component of

GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Bos taurus)

Inferred From

CSF2 [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_776452.1

OpenTargets

ENSG00000164400

Ensembl

ENSBTAT00000002054, ENSBTAG00000001570, ENSBTAP00000002054

VGNC

27755

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