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MFN2 [mitochondrial outer membrane]
Stable Identifier
R-BTA-5205668
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
mitochondrial outer membrane
Synonyms
K48polyUb-MFN2, D7GLD0
Locations in the PathwayBrowser
Expand all
Autophagy (Bos taurus)
Macroautophagy (Bos taurus)
Selective autophagy (Bos taurus)
Mitophagy (Bos taurus)
PINK1-PRKN Mediated Mitophagy (Bos taurus)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Bos taurus)
ATG5:ATG12:LC3:K48polyUB Mitophagy Substrates:SQSTM1 [phagocytic vesicle] (Bos taurus)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Bos taurus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Bos taurus)
MFN2 [mitochondrial outer membrane] (Bos taurus)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Bos taurus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Bos taurus)
MFN2 [mitochondrial outer membrane] (Bos taurus)
Parkin promotes the ubiquitination of mitochondrial substrates (Bos taurus)
MFN2 [mitochondrial outer membrane] (Bos taurus)
p62 binds ubiquitinated mitochondrial substrates (Bos taurus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Bos taurus)
MFN2 [mitochondrial outer membrane] (Bos taurus)
MFN2 [mitochondrial outer membrane] (Bos taurus)
p62 links damaged mitochondria to LC3 (Bos taurus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Bos taurus)
MFN2 [mitochondrial outer membrane] (Bos taurus)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Bos taurus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Bos taurus)
MFN2 [mitochondrial outer membrane] (Bos taurus)
External Reference Information
External Reference
UniProt:D7GLD0
Gene Names
MFN2
Reference Genes
ENSEMBL:ENSBTAG00000005314.6
Other Identifiers
534574
GO:0000166
GO:0001825
GO:0003824
GO:0003924
GO:0005525
GO:0005739
GO:0005741
GO:0005856
GO:0006626
GO:0006886
GO:0006914
GO:0007005
GO:0007006
GO:0008053
GO:0012501
GO:0015630
GO:0016020
GO:0016787
GO:0023052
GO:0031625
GO:0034497
GO:0043226
GO:0046580
GO:0048593
GO:0048856
GO:0051646
GO:0061024
GO:0061734
GO:0120162
GO:1904707
GO:1905461
Participates
as an input of
p62 binds ubiquitinated mitochondrial substrates (Bos taurus)
as an output of
Parkin promotes the ubiquitination of mitochondrial substrates (Bos taurus)
as a component of
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Bos taurus)
Other forms of this molecule
MFN2 [mitochondrial outer membrane]
Inferred From
K48polyUb-MFN2 [mitochondrial outer membrane]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K48-linked polyubiquitin chain [cytosol]) at unknown position
Modification
K48-linked polyubiquitin chain [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
OpenTargets
ENSG00000116688
Ensembl
ENSBTAT00000080672
,
ENSBTAG00000005314
,
ENSBTAP00000070841
,
ENSBTAP00000043671
,
ENSBTAT00000046364
VGNC
31428
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